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Corine J Houtman, Rob Ten Broek, Abraham Brouwer
Emission of compounds with biological activities from waste water treatment plant (WWTP) effluents into surface waters is a topic of concern for ecology and drinking water quality. We investigated the occurrence of hormone-like activities in waste water sample extracts from four Dutch WWTPs and pursued to identify compounds responsible for them. To this aim, in vitro reporter gene bioassays for androgenic, anti-androgenic, estrogenic, glucocorticoid and progestogenic activity and a UPLC-tQ-MS target analysis method for 25 steroid hormones used in high volumes in pharmacy were applied...
March 5, 2018: Science of the Total Environment
Khoa T D Thai, Hannelore Götz, Bibi C G C Slingerland, Janienne Klaasse, Martin Schutten, Corine H GeurtsvanKessel
BACKGROUND: Correct identification of blood borne viral infections, such as hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) is crucial in detection and follow up of infection in patients. OBJECTIVES: We evaluated the diagnostic performance of the DiaSorin LIAISON XL (LIAISON XL) for screening of HBV, HCV and HIV infection. In addition, we investigated the variability of the signal-to-cuttoff ratio (S/CO) of the LIAISON XL HIV Ag/Ab assay and it's predictive value in subsequent confirmation of HIV-1 infection...
February 27, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Nick Zwart, Shan Li Nio, Corine J Houtman, Jacob De Boer, Jeroen Kool, Timo Hamers, Marja H Lamoree
Effect-Directed Analysis (EDA) is a commonly used approach for effect-based identification of endocrine disruptive chemicals in complex (environmental) mixtures. For routine toxicity assessment of e.g. water samples however, current EDA approaches are considered time consuming and laborious. We achieved faster EDA and identification, by downscaling of sensitive cell-based hormone reporter gene assays and increasing fractionation resolution to allow testing of smaller fractions with reduced complexity. The high-resolution EDA approach is demonstrated by analysis of four environmental passive sampler extracts...
March 16, 2018: Environmental Science & Technology
Yang Gu, Donna Thompson, Jie Xu, David F Lewis, John A Morgan, Danielle B Cooper, Charles E McCathran, Yuping Wang
OBJECTIVE: Corin is a serine protease that converts pro-atrial natriuretic peptide (pro-ANP) to atrial natriuretic peptide (ANP), a cardiac hormone that regulates salt-water balance and blood pressure. ANP is degraded by natriuretic peptide receptor (NPR). This study was to determine if aberrant pro-ANP/corin/NPR signaling is present in maternal vascular system in preeclampsia. STUDY DESIGN: Maternal venous blood was obtained from 197 pregnant women (84 normotensive, 16 complicated with chronic hypertension (CHT), 11 mild and 86 severe preeclampsia)...
January 2018: Pregnancy Hypertension
Najla El-Hachem, Nadia Habel, Tanesha Naiken, Hanene Bzioueche, Yann Cheli, Guillaume E Beranger, Emilie Jaune, Florian Rouaud, Nicolas Nottet, Frédéric Reinier, Céline Gaudel, Pascale Colosetti, Corine Bertolotto, Robert Ballotti
HACE1 is an E3 ubiquitin ligase described as a tumour suppressor because HACE1-knockout mice develop multi-organ, late-onset cancers and because HACE1 expression is lost in several neoplasms, such as Wilms' tumours and colorectal cancer. However, a search of public databases indicated that HACE1 expression is maintained in melanomas. We demonstrated that HACE1 promoted melanoma cell migration and adhesion in vitro and was required for mouse lung colonisation by melanoma cells in vivo. Transcriptomic analysis of HACE1-depleted melanoma cells revealed an inhibition of ITGAV and ITGB1 as well changes in other genes involved in cell migration...
March 7, 2018: Cell Death and Differentiation
Corine Mouton Dorey, Holger Baumann, Nikola Biller-Andorno
BACKGROUND: There is a growing interest in aggregating more biomedical and patient data into large health data sets for research and public benefits. However, collecting and processing patient data raises new ethical issues regarding patient's rights, social justice and trust in public institutions. The aim of this empirical study is to gain an in-depth understanding of the awareness of possible ethical risks and corresponding obligations among those who are involved in projects using patient data, i...
March 7, 2018: BMC Medical Ethics
Corine M Visscher, Maarten J Schouten, Lannie Ligthart, Caroline Mhh van Houtem, Ad de Jongh, Dorret I Boomsma
AIMS: (1) To examine the heritability of TMD pain and of neck pain; and (2) to estimate the potential overlap in genetic and environmental factors influencing TMD pain and neck pain. METHODS: Data from 2,238 adult female twins who completed a survey on TMD pain and neck pain were analyzed. The total variance of TMD pain and neck pain was decomposed into variance attributable to additive genetic effects and nonshared environmental effects. Bivariate structural equation modeling was applied to estimate trait-specific and genetic effects shared between traits...
March 6, 2018: Journal of Oral & Facial Pain and Headache
Corine Dijk, Agneta H Fischer, Nexhmedin Morina, Charlotte van Eeuwijk, Gerben A van Kleef
Socially anxiety may be related to a different pattern of facial mimicry and contagion of others' emotions. We report two studies in which participants with different levels of social anxiety reacted to others' emotional displays, either shown on a computer screen (Study 1) or in an actual social interaction (Study 2). Study 1 examined facial mimicry and emotional contagion in response to displays of happiness, anger, fear, and contempt. Participants mimicked negative and positive emotions to some extent, but we found no relation between mimicry and the social anxiety level of the participants...
2018: Journal of Nonverbal Behavior
Corine Ekhart, Florence van Hunsel, Joep Scholl, Sieta de Vries, Eugene van Puijenbroek
INTRODUCTION: Several studies have investigated sex as a risk factor for the occurrence of adverse drug reactions (ADRs) and found that women are more likely to experience ADRs than men. OBJECTIVE: The aim of this explorative study was to investigate whether differences exist in reported ADRs of selective serotonin reuptake inhibitors (SSRIs) for men and women in the database of the Netherlands Pharmacovigilance Centre Lareb. METHODS: A ratio of reports concerning women and men, corrected for the number of users, was calculated for all the ADRs reported on SSRIs...
February 26, 2018: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
Séverine Tasker, Regina Hofmann-Lehmann, Sándor Belák, Tadeusz Frymus, Diane D Addie, Maria Grazia Pennisi, Corine Boucraut-Baralon, Herman Egberink, Katrin Hartmann, Margaret J Hosie, Albert Lloret, Fulvio Marsilio, Alan D Radford, Etienne Thiry, Uwe Truyen, Karin Möstl
OVERVIEW: Haemoplasmas are haemotropic bacteria that can induce anaemia in a wide range of mammalian species. Infection in cats: Mycoplasma haemofelis is the most pathogenic of the three main feline haemoplasma species known to infect cats. ' Candidatus Mycoplasma haemominutum' and ' Candidatus Mycoplasma turicensis' are less pathogenic but can result in disease in immunocompromised cats. Male, non-pedigree cats with outdoor access are more likely to be haemoplasma infected, and ' Candidatus M haemominutum' is more common in older cats...
March 2018: Journal of Feline Medicine and Surgery
Emmanuel Hakizimana, Corine Karema, Dunia Munyakanage, John Githure, Jean Baptiste Mazarati, Jon Eric Tongren, Willem Takken, Agnes Binagwaho, Constantianus J M Koenraadt
To date, the Republic of Rwanda has not systematically reported on distribution, diversity and malaria infectivity rate of mosquito species throughout the country. Therefore, we assessed the spatial and temporal variation of mosquitoes in the domestic environment, as well as to assess nocturnal biting behavior and infection patterns of the main malaria vectors in Rwanda. For this purpose, mosquitoes were collected monthly from 2010 to 2013 by human landing catches (HLC) and pyrethrum spray collections (PSC) in seven sentinel sites...
February 21, 2018: Acta Tropica
Anieta M Sieuwerts, Bianca Mostert, Michelle van der Vlugt-Daane, Jaco Kraan, Corine Beaufort, Mai Van, Wendy J C Prager, Bram De Laere, Nick Beije, Paul Hamberg, Hans M Westgeest, Metin Tascilar, Luc Y Dirix, Wendy Onstenk, Ronald de Wit, Martijn P Lolkema, Ron H J Mathijssen, John W M Martens, Stefan Sleijfer
Recent reports have emphasized the clinical relevance of detecting the androgen receptor splice variant 7 (AR-V7) in circulating tumor cells (CTCs). Our aim was to set up a validated multicenter pipeline to measure AR-V7 by RT-qPCR in RNA isolated from CellSearch-enriched CTCs to provide an AR-V7 positive/negative score in a clinically acceptable time range. CellSearch-enirched CTCs from metastatic castration-resistant prostate cancer patients were characterized by RT-qPCR. After optimization it was prospectively tested whether it was possible to report the AR-V7 status within 11 days (PRELUDE study)...
February 20, 2018: Journal of Molecular Diagnostics: JMD
Simone A Joosten, Krista E van Meijgaarden, Sandra M Arend, Corine Prins, Fredrik Oftung, Gro Ellen Korsvold, Sandra V Kik, Rob Jw Arts, Reinout van Crevel, Mihai G Netea, Tom Hm Ottenhoff
The lack of defined correlates of protection hampers development of vaccines against tuberculosis (TB). In vitro mycobacterial outgrowth assays are thought to better capture the complexity of the human host/Mycobacterium tuberculosis (Mtb) interaction. We used a PBMC-based "mycobacterial-growth-inhibition-assay" (MGIA) to investigate the capacity to control outgrowth of Bacille Calmette-Guérin (BCG). Interestingly, strong control of BCG outgrowth was observed almost exclusively in individuals with recent exposure to Mtb, but not in (long-term) latent TB infection, and only modestly in BCG vaccinees...
February 20, 2018: Journal of Clinical Investigation
Donna C Jessop, Susan Ayers, Flora Burn, Corin Ryda
OBJECTIVE: Self-affirmation has repeatedly been shown to reduce adverse psychological and physiological responses to stress. However, it is plausible that self-affirmation could exacerbate negative reactions to stress under certain conditions. The current research explored whether self-affirmation would increase negative psychological responses to a stressor occurring in a central life domain characterised by low levels of control. DESIGN: Female participants (Study 1 N = 132; Study 2 N = 141) completed baseline measures of anxiety and mood...
February 19, 2018: Psychology & Health
Naichuan Su, Arjen J van Wijk, Corine M Visscher, Frank Lobbezoo, Geert J M G van der Heijden
OBJECTIVES: The aim was to assess the added diagnostic value of ultrasonography (US) for establishing the presence or absence of disc displacements (DDs) in temporomandibular joints (TMJs). MATERIALS AND METHODS: Pubmed and EMBASE were searched electronically to identify diagnostic accuracy studies that assessed the diagnostic value of US for the diagnosis of DD, using Magnetic resonance imaging (MRI) as the reference standard. Meta-analyses were performed with Metadisc 1...
February 17, 2018: Clinical Oral Investigations
Anna Lövgren, Hasti Parvaneh, Frank Lobbezoo, Birgitta Häggman-Henrikson, Anders Wänman, Corine Mirjam Visscher
OBJECTIVE: To determine the diagnostic accuracy of three screening questions (3Q/TMD) in relation to the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD), in a specialized clinic. MATERIAL AND METHODS: Consecutive patients, >18 years, referred with a possible TMD complaint to the Orofacial Pain and Dysfunction clinic, Academic Centre for Dentistry Amsterdam, the Netherlands, were included in the study. All patients (n = 449; mean age 44 years; 72% females), answered the 3Q/TMD and the DC/TMD questionnaire before a DC/TMD examination...
February 15, 2018: Acta Odontologica Scandinavica
Chaeryon Kang, Holly Janes, Parvin Tajik, Henk Groen, Ben Mol, Corine Koopmans, Kim Broekhuijsen, Eva Zwertbroek, Maria van Pampus, Maureen Franssen
Biomarkers that predict treatment effects may be used to guide treatment decisions, thus improving patient outcomes. A meta-analysis of individual participant data (IPD) is potentially more powerful than a single-study data analysis in evaluating markers for treatment selection. Our study was motivated by the IPD that were collected from 2 randomized controlled trials of hypertension and preeclampsia among pregnant women to evaluate the effect of labor induction over expectant management of the pregnancy in preventing progression to severe maternal disease...
February 14, 2018: Statistics in Medicine
Sandra N Slagter, Eva Corpeleijn, Melanie M van der Klauw, Anna Sijtsma, Linda G Swart-Busscher, Corine W M Perenboom, Jeanne H M de Vries, Edith J M Feskens, Bruce H R Wolffenbuttel, Daan Kromhout, Jana V van Vliet-Ostaptchouk
BACKGROUND: Diversity in the reported prevalence of metabolically healthy obesity (MHO), suggests that modifiable factors may be at play. We evaluated differences in dietary patterns and physical activity between MHO and metabolically unhealthy obesity (MUO). METHODS: Cross-sectional data of 9270 obese individuals (30-69 years) of the Lifelines Cohort Study was used. MHO was defined as obesity and no metabolic syndrome risk factors and no cardiovascular disease history...
February 12, 2018: Nutrition Journal
Karien E A Hack, Marijn E M S Vereycken, Helen L Torrance, Corine Koopman-Esseboom, Jan B Derks
INTRODUCTIO: The aim of this study was to compare pregnancy outcomes in twin pregnancies after ACand spontaneous conception, according to chorionicity. MATERIAL AND METHODS: Retrospective cohort study of 1305 twin pregnancies between 1995 and 2015. All spontaneous (n=731) and assisted conception conceived twin pregnancies (n=574) with antenatal care and delivery in University Medical Center Utrecht, The Netherlands, a tertiary obstetric care center were studied according to chorionicity...
February 11, 2018: Acta Obstetricia et Gynecologica Scandinavica
Badrul Islam, Zhahirul Islam, Corine H GeurtsvanKessel, Israt Jahan, Hubert P Endtz, Quazi D Mohammad, Bart C Jacobs
We describe the frequency, clinical features, and electrophysiological and immunological phenotypes of Guillain-Barré Syndrome (GBS) patients treated at a single institution in Bangladesh who had preceding chicken pox (primary Varicella-zoster virus [VZV] infection) within 4 weeks of GBS onset. A literature review of GBS cases preceding VZV infection is also provided. Diagnosis of GBS was based on the National Institute of Neurological Disorders and Stroke criteria for GBS. Serum anti-VZV IgM and IgG antibodies were quantified by indirect chemiluminescence immunoassay (CLIA); anti-Campylobacter jejuni IgG, IgM, and IgA antibodies and anti-ganglioside GM1 IgM and IgG antibodies, by enzyme-linked immunosorbent assays...
March 2018: European Journal of Clinical Microbiology & Infectious Diseases
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