keyword
https://read.qxmd.com/read/38635220/positive-and-negative-intergroup-contact-and-newcomer-immigrants-psychological-adjustment
#1
JOURNAL ARTICLE
Corine Stella Kana Kenfack, Francesca Prati, Sarina Schaefer, Oliver Christ, Miles Hewstone, Silvia Moscatelli, Monica Rubini
OBJECTIVES: The present research investigates the associations between immigrants' positive and negative contact with the majority group and their psychological well-being, as indicators of their psychosocial adjustment to the host society. Perceived personal discrimination and relative deprivation in comparison to the majority group are assessed as mediators of the associations between intergroup contact and psychological well-being. METHOD: We conducted a three-wave longitudinal study with newcomer African immigrants living in Italy ( N = 240; 61...
April 18, 2024: Cultural Diversity & Ethnic Minority Psychology
https://read.qxmd.com/read/38633367/a-light-touch-solar-photocatalysis-detoxifies-oil-sands-process-affected-waters-prior-to-significant-treatment-of-naphthenic-acids
#2
JOURNAL ARTICLE
Timothy M C Leshuk, Zachary W Young, Brad Wilson, Zi Qi Chen, Danielle A Smith, Greg Lazaris, Mary Gopanchuk, Sean McLay, Corin A Seelemann, Theo Paradis, Asfaw Bekele, Rodney Guest, Hafez Massara, Todd White, Warren Zubot, Daniel J Letinski, Aaron D Redman, D Grant Allen, Frank Gu
Environmental reclamation of Canada's oil sands tailings ponds is among the single largest water treatment challenges globally. The toxicity of oil sands process-affected water (OSPW) has been associated with its dissolved organics, a complex mixture of naphthenic acid fraction components (NAFCs). Here, we evaluated solar treatment with buoyant photocatalysts (BPCs) as a passive advanced oxidation process (P-AOP) for OSPW remediation. Photocatalysis fully degraded naphthenic acids (NAs) and acid extractable organics (AEO) in 3 different OSPW samples...
April 12, 2024: ACS ES&T water
https://read.qxmd.com/read/38626085/impact-of-ghrelin-on-islet-size-in-non-pregnant-and-pregnant-female-mice
#3
JOURNAL ARTICLE
Deepali Gupta, Avi W Burstein, Kripa Shankar, Salil Varshney, Omprakash Singh, Sherri Osborne-Lawrence, Corine P Richard, Jeffrey M Zigman
Reducing ghrelin by ghrelin gene knockout (GKO), ghrelin-cell ablation, or high-fat diet feeding increases islet size and β-cell mass in male mice. Here, we determined if reducing ghrelin also enlarges islets in females, and if pregnancy-associated changes in islet size are related to reduced ghrelin. Islet size and β-cell mass were larger (P=0.057 for β-cell mass) in female GKO mice. Pregnancy was associated with reduced ghrelin and increased LEAP2 [a ghrelin receptor (GHSR) antagonist] in WT mice...
April 16, 2024: Endocrinology
https://read.qxmd.com/read/38614151/modification-of-the-phenyl-ring-b-of-phenyl-4-2-oxoimidazolidin-1-yl-benzenesulfonates-by-pyridinyl-moiety-leads-to-novel-antimitotics-targeting-the-colchicine-binding-site
#4
JOURNAL ARTICLE
Vincent Ouellette, Chahrazed Bouzriba, Atziri Corin Chavez Alvarez, Geneviève Hamel-Côté, Sébastien Fortin
A series of 8 novel pyridinyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates (PYRIB-SOs) were designed, prepared and evaluated for their mechanism of action. PYRIB-SOs were found to have antiproliferative activity in the nanomolar to submicromolar range on several breast cancer cell lines. Moreover, subsequent biofunctional assays indicated that the most potent PYRIB-SOs 1-3 act as antimitotics binding to the colchicine-binding site (C-BS) of α, β-tubulin and that they arrest the cell cycle progression in the G2/M phase...
April 11, 2024: Bioorganic & Medicinal Chemistry Letters
https://read.qxmd.com/read/38609962/network-analysis-on-psychopathological-symptoms-psychological-measures-quality-of-life-and-covid-19-related-factors-in-chinese-psychiatric-patients-in-hong-kong
#5
JOURNAL ARTICLE
Vivian Shi Cheng Fung, Joe Kwun Nam Chan, Eileena Mo Ching Chui, Corine Sau Man Wong, Ryan Sai Ting Chu, Yuen Kiu So, Jacob Man Tik Chan, Albert Kar Kin Chung, Krystal Chi Kei Lee, Heidi Ka Ying Lo, Calvin Pak Wing Cheng, Chi Wing Law, Wai Chi Chan, Wing Chung Chang
BACKGROUND: Psychiatric patients are susceptible to adverse mental health impacts during COVID-19, but complex interplays between psychopathology and pandemic-related variables remain elusive. This study aimed to investigate concomitant associations between psychopathological symptoms, psychological measures and COVID-19 related variables in Chinese psychiatric patients during the peak of fifth pandemic wave in Hong Kong. METHODS: We employed network analysis to investigate inter-relationships among psychopathological symptoms (including depression, anxiety, post-traumatic stress disorder-like [PTSD-like] symptoms, insomnia, psychotic symptoms), cognitive complaints, health-related quality of life, loneliness, resilience and selected pandemic-related factors in 415 psychiatric outpatients between 28 March and 8 April, 2022...
April 12, 2024: BMC Psychiatry
https://read.qxmd.com/read/38605982/the-relationship-between-remotely-sensed-spectral-heterogeneity-and-bird-diversity-is-modulated-by-landscape-type
#6
JOURNAL ARTICLE
Dominika Prajzlerová, Vojtěch Barták, Petr Keil, Vítězslav Moudrý, Markéta Zikmundová, Petr Balej, François Leroy, Duccio Rocchini, Michela Perrone, Marco Malavasi, Petra Šímová
To identify areas of high biodiversity and prioritize conservation efforts, it is crucial to understand the drivers of species richness patterns and their scale dependence. While classified land cover products are commonly used to explain bird species richness, recent studies suggest that unclassified remote-sensed images can provide equally good or better results. In our study, we aimed to investigate whether unclassified multispectral data from Landsat 8 can replace image classification for bird diversity modeling...
April 2024: International Journal of Applied Earth Observation and Geoinformation: ITC Journal
https://read.qxmd.com/read/38600549/laboratory-evaluation-of-the-contact-irritancy-of-a-clothianidin-solo-formulation-vs-clothianidin-deltamethrin-mixture-formulations-for-indoor-residual-spraying-against-pyrethroid-resistant-anopheles-gambiae-sensu-lato
#7
JOURNAL ARTICLE
Thomas Syme, Boris N'dombidjé, Aicha Odjo, Martial Gbegbo, Damien Todjinou, Corine Ngufor
BACKGROUND: Clothianidin-based indoor residual spraying (IRS) formulations have become available for malaria control as either solo formulations of clothianidin or a mixture of clothianidin with the pyrethroid deltamethrin. While both formulations have been successfully used for malaria control, studies investigating the effect of the pyrethroid in IRS mixtures may help improve our understanding for development of future IRS products. It has been speculated that the irritant effect of the pyrethroid in the mixture formulation may result in shorter mosquito contact times with the treated walls potentially leading to a lower impact...
April 10, 2024: Parasites & Vectors
https://read.qxmd.com/read/38597187/-hypertension-in-pregnancy-intervention-trial-at-term-and-disproportionate-intrauterine-growth-intervention-trial-at-term-studies
#8
JOURNAL ARTICLE
Marielle G van Pampus, Joris A M van der Post, Corine J Verhoeven, Corine M Koopmans, Josje Langenveld, Kim Broekhuijsen, Catherine M W de Sonnaville, Karin van der Tuuk, Kim Boers, Henk Groen, Sylvia Vijgen, Denise Bijlenga, Sicco Scherjon, Ben W Mol
In 2003, in the context of a national research funding program in which obstetric research was prioritized, several perinatal centers took the initiative to jointly submit a number of applications to the subsidy programs of Effectiveness Research and Prevention of ZonMw. This has led to the funding of the Obstetric Consortium with several projects, including the "Hypertension in Pregnancy Intervention Trial At Term" and the "Disproportionate Intrauterine Growth Intervention Trial At Term" studies. The studies showed that induction of labor for hypertension and growth restriction at term was the appropriate management...
April 10, 2024: Clinical Obstetrics and Gynecology
https://read.qxmd.com/read/38589665/seed-dormancy-climate-changes-desertification-and-soil-use-transformation-threaten-the-mediterranean-endemic-monospecific-plant-petagnaea-gussonei
#9
JOURNAL ARTICLE
Giuseppe Bonanno, Vincenzo Veneziano
This study investigated the germination capacity (endogenous factor) of Petagnaea gussonei (Spreng.) Rauschert, an endemic monospecific plant considered as a relict species of the ancient Mediterranean Tertiary flora. This investigation focused also on the temporal trends of soil-use, climate and desertification (exogenous factors) across the natural range of P. gussonei. The final germination percentage showed low values between 14 and 32%, the latter obtained with GA3 and agar at 10 °C. The rising temperatures in the study area will further increase the dormancy of P...
April 8, 2024: Scientific Reports
https://read.qxmd.com/read/38585825/the-recurrent-deep-intronic-pseudoexon-inducing-variant-col6a1-c-930-189c-t-results-in-a-consistently-severe-phenotype-of-col6-related-dystrophy-towards-clinical-trial-readiness-for-splice-modulating-therapy
#10
A Reghan Foley, Véronique Bolduc, Fady Guirguis, Sandra Donkervoort, Ying Hu, Rotem Orbach, Riley M McCarty, Apurva Sarathy, Gina Norato, Beryl B Cummings, Monkol Lek, Anna Sarkozy, Russell J Butterfield, Janbernd Kirschner, Andrés Nascimento, Daniel Natera-de Benito, Susana Quijano-Roy, Tanya Stojkovic, Luciano Merlini, Giacomo Comi, Monique Ryan, Denise McDonald, Pinki Munot, Grace Yoon, Edward Leung, Erika Finanger, Meganne E Leach, James Collins, Cuixia Tian, Payam Mohassel, Sarah B Neuhaus, Dimah Saade, Benjamin T Cocanougher, Mary-Lynn Chu, Mena Scavina, Carla Grosmann, Randal Richardson, Brian D Kossak, Sidney M Gospe, Vikram Bhise, Gita Taurina, Baiba Lace, Monica Troncoso, Mordechai Shohat, Adel Shalata, Sophelia H S Chan, Manu Jokela, Johanna Palmio, Göknur Haliloğlu, Cristina Jou, Corine Gartioux, Herimela Solomon-Degefa, Carolin D Freiburg, Alvise Schiavinato, Haiyan Zhou, Sara Aguti, Yoram Nevo, Ichizo Nishino, Cecilia Jimenez-Mallebrera, Shireen R Lamandé, Valérie Allamand, Francesca Gualandi, Alessandra Ferlini, Daniel G MacArthur, Steve D Wilton, Raimund Wagener, Enrico Bertini, Francesco Muntoni, Carsten G Bönnemann
Collagen VI-related dystrophies (COL6-RDs) manifest with a spectrum of clinical phenotypes, ranging from Ullrich congenital muscular dystrophy (UCMD), presenting with prominent congenital symptoms and characterised by progressive muscle weakness, joint contractures and respiratory insufficiency, to Bethlem muscular dystrophy, with milder symptoms typically recognised later and at times resembling a limb girdle muscular dystrophy, and intermediate phenotypes falling between UCMD and Bethlem muscular dystrophy...
March 29, 2024: medRxiv
https://read.qxmd.com/read/38580096/the-effect-of-administering-preprocedural-vitamin-k-on-the-international-normalized-ratio-in-patients-anticoagulated-with-acenocoumarol-vitkace-study
#11
JOURNAL ARTICLE
Stella Bijkerk, Harm J Lourens, Wout G N Mares, Corine A van Kampen, Maurits J van der Veen, Henk J Adriaansen, Erik D Ponfoort, Barbara Festen, G Wouter Westendorp, Jörgen M P Rovers, Gerie M C Groot, Hans-Peter R Bootsma, Linde M Amelung, Sander Bins, Gerjo Velders, Remy H H Bemelmans
BACKGROUND: The effect of the vitamin K antagonist (VKA) acenocoumarol on coagulation needs to be reversed when patients undergo an invasive procedure with considerable bleeding risk. A strategy to achieve this is administering oral vitamin K before a procedure while continuing acenocoumarol. OBJECTIVES: To assess the effect on periprocedural International Normalized Ratio (INR)-values and safety using oral vitamin K as anticoagulant reversal method. METHODS: In this prospective cohort study, consecutive patients using acenocoumarol undergoing elective procedures between 2019 and 2022 were included...
April 3, 2024: Journal of Thrombosis and Haemostasis: JTH
https://read.qxmd.com/read/38576494/vasorelaxant-and-hypotensive-effects-of-an-ethanolic-extract-of-nymphaea-pubescens-and-its-main-compound-quercetin-3-methyl-ether-3-o-%C3%AE-xylopyranoside
#12
JOURNAL ARTICLE
Teerapap Panklai, Kornkanok Ingkaninan, Krongkarn Chootip, Prapapan Temkitthawon, Nungruthai Suphrom, Maude Tournier-Nappey, Corine Girard, Céline Demougeot, Perle Totoson
Aim: Nymphaea plants were traditionally used to treat diseases associated with endothelial dysfunction. The present study investigated the effects of an ethanolic extract of Nymphaea pubescens Willd. (commonly named water lily, WL) and its main compound 1 (quercetin 3-methyl ether 3'-O- β -xylopyranoside) on vascular function in rats. Materials and methods: The vasorelaxant effects of the WL extract and its main compound 1 and their underlying mechanisms of action were evaluated on isolated mesenteric arteries from Wistar rats...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38575284/structural-support-for-large-to-total-nasal-reconstruction
#13
REVIEW
Corin M Kinkhabwala, Krishna G Patel
When large defects of the nose are present, it is imperative to address all 3 layers: the external skin envelope, the osteocartilaginous support, and the inner mucosal lining. The middle structural framework is the primary factor in determining the overall shape of the nose, in addition to facilitating a functional and patent airway. As such, its reconstruction must be robust enough to provide lasting osteocartilaginous support while minimizing disfiguring bulk. The goal is replacement of missing tissue with grafts of similar strength, size, and shape...
May 2024: Facial Plastic Surgery Clinics of North America
https://read.qxmd.com/read/38568940/the-longitudinal-relationship-between-fear-of-movement-and-physical-activity-after-cardiac-hospitalization-a-cross-lagged-panel-model
#14
JOURNAL ARTICLE
Paul Keessen, Kees Jan Kan, Gerben Ter Riet, Bart Visser, Harald T Jørstad, Corine H M Latour, Ingrid C D van Duijvenbode, Wilma J M Scholte Op Reimer
BACKGROUND: Little is known about the association between fear of movement (kinesiophobia) and objectively measured physical activity (PA), the first 12 weeks after cardiac hospitalization. PURPOSE: To assess the longitudinal association between kinesiophobia and objectively measured PA and to assess the factor structure of kinesiophobia. METHODS: We performed a longitudinal observational study. PA was continuously measured from hospital discharge to 12 weeks using the Personal Activity Monitor...
2024: PloS One
https://read.qxmd.com/read/38567196/dolutegravir-lamivudine-is-noninferior-to-continuing-dolutegravir-and-non-dolutegravir-based-triple-drug-antiretroviral-therapy-in-virologically-suppressed-people-with-human-immunodeficiency-virus-dualing-prospective-nationwide-matched-cohort-study
#15
Marta Vasylyev, Ferdinand W N M Wit, Carlijn C E Jordans, Robin Soetekouw, Steven F L van Lelyveld, Gert-Jan Kootstra, Corine E Delsing, Heidi S M Ammerlaan, Marjo E E van Kasteren, Annemarie E Brouwer, Eliane M S Leyten, Mark A A Claassen, Robert-Jan Hassing, Jan G den Hollander, Marcel van den Berge, Anna H E Roukens, Wouter F W Bierman, Paul H P Groeneveld, Selwyn H Lowe, Berend J van Welzen, Olivier Richel, Jeannine F Nellen, Guido E L van den Berk, Marc van der Valk, Bart J A Rijnders, Casper Rokx
BACKGROUND: Confirming the efficacy of dolutegravir/lamivudine in clinical practice solidifies recommendations on its use. METHODS: Prospective cohort study (DUALING) in 24 human immunodeficiency virus (HIV) treatment centers in the Netherlands. HIV RNA-suppressed cases were on triple-drug antiretroviral regimens without prior virological failure or resistance and started dolutegravir/lamivudine. Cases were 1:2 matched to controls on triple-drug antiretroviral regimens by the use of dolutegravir-based regimens, age, sex, transmission route, CD4+ T-cell nadir, and HIV RNA zenith...
April 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38565681/author-correction-one-sixth-of-amazonian-tree-diversity-is-dependent-on-river-floodplains
#16
John Ethan Householder, Florian Wittmann, Jochen Schöngart, Maria Teresa Fernandez Piedade, Wolfgang J Junk, Edgardo Manuel Latrubesse, Adriano Costa Quaresma, Layon O Demarchi, Guilherme de S Lobo, Daniel P P de Aguiar, Rafael L Assis, Aline Lopes, Pia Parolin, Iêda Leão do Amaral, Luiz de Souza Coelho, Francisca Dionízia de Almeida Matos, Diógenes de Andrade Lima Filho, Rafael P Salomão, Carolina V Castilho, Juan Ernesto Guevara-Andino, Marcelo de Jesus Veiga Carim, Oliver L Phillips, Dairon Cárdenas López, William E Magnusson, Daniel Sabatier, Juan David Cardenas Revilla, Jean-François Molino, Mariana Victória Irume, Maria Pires Martins, José Renan da Silva Guimarães, José Ferreira Ramos, Domingos de Jesus Rodrigues, Olaf S Bánki, Carlos A Peres, Nigel C A Pitman, Joseph E Hawes, Everton José Almeida, Luciane Ferreira Barbosa, Larissa Cavalheiro, Márcia Cléia Vilela Dos Santos, Bruno Garcia Luize, Evlyn Márcia Moraes de Leão Novo, Percy Núñez Vargas, Thiago Sanna Freire Silva, Eduardo Martins Venticinque, Angelo Gilberto Manzatto, Neidiane Farias Costa Reis, John Terborgh, Katia Regina Casula, Flávia R C Costa, Euridice N Honorio Coronado, Abel Monteagudo Mendoza, Juan Carlos Montero, Ted R Feldpausch, Gerardo A Aymard C, Chris Baraloto, Nicolás Castaño Arboleda, Julien Engel, Pascal Petronelli, Charles Eugene Zartman, Timothy J Killeen, Lorena Maniguaje Rincón, Beatriz S Marimon, Ben Hur Marimon-Junior, Juliana Schietti, Thaiane R Sousa, Rodolfo Vasquez, Bonifacio Mostacedo, Dário Dantas do Amaral, Hernán Castellanos, Marcelo Brilhante de Medeiros, Marcelo Fragomeni Simon, Ana Andrade, José Luís Camargo, William F Laurance, Susan G W Laurance, Emanuelle de Sousa Farias, Maria Aparecida Lopes, José Leonardo Lima Magalhães, Henrique Eduardo Mendonça Nascimento, Helder Lima de Queiroz, Roel Brienen, Pablo R Stevenson, Alejandro Araujo-Murakami, Tim R Baker, Bruno Barçante Ladvocat Cintra, Yuri Oliveira Feitosa, Hugo F Mogollón, Janaína Costa Noronha, Flávia Rodrigues Barbosa, Rainiellen de Sá Carpanedo, Joost F Duivenvoorden, Miles R Silman, Leandro Valle Ferreira, Carolina Levis, José Rafael Lozada, James A Comiskey, Freddie C Draper, José Julio de Toledo, Gabriel Damasco, Nállarett Dávila, Roosevelt García-Villacorta, Alberto Vicentini, Fernando Cornejo Valverde, Alfonso Alonso, Luzmila Arroyo, Francisco Dallmeier, Vitor H F Gomes, Eliana M Jimenez, David Neill, Maria Cristina Peñuela Mora, Fernanda Antunes Carvalho, Fernanda Coelho de Souza, Kenneth J Feeley, Rogerio Gribel, Marcelo Petratti Pansonato, Marcos Ríos Paredes, Jos Barlow, Erika Berenguer, Kyle G Dexter, Joice Ferreira, Paul V A Fine, Marcelino Carneiro Guedes, Isau Huamantupa-Chuquimaco, Juan Carlos Licona, Toby Pennington, Boris Eduardo Villa Zegarra, Vincent Antoine Vos, Carlos Cerón, Émile Fonty, Terry W Henkel, Paul Maas, Edwin Pos, Marcos Silveira, Juliana Stropp, Raquel Thomas, Doug Daly, William Milliken, Guido Pardo Molina, Ima Célia Guimarães Vieira, Bianca Weiss Albuquerque, Wegliane Campelo, Thaise Emilio, Alfredo Fuentes, Bente Klitgaard, José Luis Marcelo Pena, Priscila F Souza, J Sebastián Tello, Corine Vriesendorp, Jerome Chave, Anthony Di Fiore, Renato Richard Hilário, Luciana de Oliveira Pereira, Juan Fernando Phillips, Gonzalo Rivas-Torres, Tinde R van Andel, Patricio von Hildebrand, William Balee, Edelcilio Marques Barbosa, Luiz Carlos de Matos Bonates, Hilda Paulette Dávila Doza, Ricardo Zárate Gómez, Therany Gonzales, George Pepe Gallardo Gonzales, Bruce Hoffman, André Braga Junqueira, Yadvinder Malhi, Ires Paula de Andrade Miranda, Linder Felipe Mozombite-Pinto, Adriana Prieto, Agustín Rudas, Ademir R Ruschel, Natalino Silva, César I A Vela, Stanford Zent, Egleé L Zent, Angela Cano, Yrma Andreina Carrero Márquez, Diego F Correa, Janaina Barbosa Pedrosa Costa, Bernardo Monteiro Flores, David Galbraith, Milena Holmgren, Michelle Kalamandeen, Marcelo Trindade Nascimento, Alexandre A Oliveira, Hirma Ramirez-Angulo, Maira Rocha, Veridiana Vizoni Scudeller, Rodrigo Sierra, Milton Tirado, Maria Natalia Umaña, Geertje van der Heijden, Emilio Vilanova Torre, Manuel Augusto Ahuite Reategui, Cláudia Baider, Henrik Balslev, Sasha Cárdenas, Luisa Fernanda Casas, William Farfan-Rios, Cid Ferreira, Reynaldo Linares-Palomino, Casimiro Mendoza, Italo Mesones, Germaine Alexander Parada, Armando Torres-Lezama, Ligia Estela Urrego Giraldo, Daniel Villarroel, Roderick Zagt, Miguel N Alexiades, Edmar Almeida de Oliveira, Karina Garcia-Cabrera, Lionel Hernandez, Walter Palacios Cuenca, Susamar Pansini, Daniela Pauletto, Freddy Ramirez Arevalo, Adeilza Felipe Sampaio, Elvis H Valderrama Sandoval, Luis Valenzuela Gamarra, Hans Ter Steege
No abstract text is available yet for this article.
April 2, 2024: Nature Ecology & Evolution
https://read.qxmd.com/read/38565183/lipid-profile-evolution-in-graves-disease-treated-with-titration-regimen-of-anti-thyroid-drugs-versus-block-and-replace-regimen
#17
JOURNAL ARTICLE
Ana-Maria Stancu, Oana Pop, Mariana Purice, Corin Badiu
The aim was to compare the lipid profile of patients with GD treated with anti-thyroid drugs (ATDs) using a titration regimen versus a block and replace regimen. This is an 18-month prospective observational study. In this study were included 149 medically treated GD patients, aged+>+18 years. Pregnant women and patients treated with radioactive iodine therapy or partial/total thyroidectomy were excluded. Patients were divided into 2 subgroups: titration (A) and block and replace (B) therapy, according to the ATD regimen used...
April 2, 2024: Hormone and Metabolic Research
https://read.qxmd.com/read/38561348/messing-with-cancer-therapy-how-the-melanoma-phenotype-predicts-checkpoint-inhibitor-response
#18
JOURNAL ARTICLE
Svenja Meierjohann, Corine Bertolotto
No abstract text is available yet for this article.
April 1, 2024: Signal Transduction and Targeted Therapy
https://read.qxmd.com/read/38552793/intradermal-delivery-of-the-third-dose-of-the-mrna-1273-sars-cov-2-vaccine-safety-and-immunogenicity-of-a-fractional-booster-dose
#19
JOURNAL ARTICLE
Geert V T Roozen, Manon L M Prins, Corine Prins, Jacqueline J Janse, Heidi L M de Gruyter, Cilia R Pothast, Wesley Huisman, Jan Pieter R Koopman, Olivia A C Lamers, Marjan Kuijer, Sebenzile K Myeni, Rob S van Binnendijk, Gerco den Hartog, Mirjam H M Heemskerk, Simon P Jochems, Mariet C W Feltkamp, Marjolein Kikkert, Frits R Rosendaal, Meta Roestenberg, Leo G Visser, Anna H E Roukens
OBJECTIVES: The aim of this study was to assess safety and immunogenicity of a dose-sparing fractional intradermal (ID) booster strategy with the mRNA-1273 COVID-19 vaccine. METHODS: COVID-19 naive adults aged 18-30 years were recruited from a previous study on primary vaccination regimens that compared 20 μg ID vaccinations with 100 μg IM vaccinations with mRNA-1273 as the primary vaccination series. Participants previously immunized with ID regimens were randomly assigned (1:1) to receive a fractional ID booster dose (20 μg) or the standard-of-care intramuscular (IM) booster dose (50 μg) of the mRNA-1273 vaccine, six months after completing their primary series (ID-ID and ID-IM group, respectively)...
March 27, 2024: Clinical Microbiology and Infection
https://read.qxmd.com/read/38547722/design-synthesis-and-biological-evaluation-of-new-2-6-difluorinated-phenyl-4-2-oxoimidazolidin-1-yl-benzenesulfonates-as-new-antimicrotubule-agents
#20
JOURNAL ARTICLE
Chahrazed Bouzriba, Mathieu Gagné-Boulet, Atziri Corin Chavez Alvarez, Vincent Ouellette, Isabelle Laverdière, Sébastien Fortin
We previously discovered a novel family of antimicrotubule agents designated as phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates (PIB-SOs). In this study, we evaluated the effect of the difluorination of the aromatic ring bearing the imidazolidin-2-one moiety (ring A) at positions 3, 5 and 2, 6 on their antiproliferative activity on four cancer cell lines, their ability to disrupt the microtubules and their toxicity toward chick embryos. We thus synthesized, characterized and biologically evaluated 24 new difluorinated PIB-SO derivatives designated as phenyl 3,5-difluoro-4-(2-oxoimidazolidin-1-yl)benzenesulfonates (3,5-PFB-SOs, 4-15) and phenyl 2,6-difluoro-4-(2-oxoimidazolidin-1-yl)benzenesulfonates (2,6-PFB-SOs, 16-27)...
March 20, 2024: Bioorganic Chemistry
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