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https://www.readbyqxmd.com/read/28945007/nonmineralized-and-mineralized-collagen-scaffolds-induce-differential-osteogenic-signaling-pathways-in-human-mesenchymal-stem-cells
#1
Qi Zhou, Xiaoyan Ren, David Bischoff, Daniel W Weisgerber, Dean T Yamaguchi, Timothy A Miller, Brendan A C Harley, Justine C Lee
The instructive capabilities of extracellular matrix components in progenitor cell differentiation have recently generated significant interest in the development of bioinspired materials for regenerative applications. Previously, a correlation was described between the osteogenic capabilities of nanoparticulate mineralized collagen glycosaminoglycan scaffolds (MC-GAG) and an autogenous activation of small mothers against decapentaplegic ( Smad1/5) in the canonical bone morphogenetic protein receptor (BMPR) pathway with a diminished extracellular signal regulated kinase 1/2 (ERK1/2) activation when compared to nonmineralized collagen glycosaminoglycan scaffolds (Col-GAG)...
September 25, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28944953/nk-cells-produce-high-levels-of-il-10-early-after-allogeneic-stem-cell-transplantation-and-suppress-development-of-acute-gvhd
#2
Yl Tracey Chan, Jianmin Zuo, Charlotte Inman, Wayne Croft, Jusnara Begum, Joanne Croudace, Francesca Kinsella, Luke Maggs, Sandeep Nagra, Jane Nunnick, Ben Abbotts, Charles Craddock, Ram Malladi, Paul Moss
Natural killer (NK) cells rapidly reconstitute following allogeneic stem cell transplantation (allo-SCT), at the time when alloreactive T cell immunity is being established. We investigated very early NK cell reconstitution in 82 patients following T cell-depleted allo-SCT. NK cell number rapidly increased, exceeding T cell reconstitution such that the NK:T cell ratio was over 40 by day 14. NK cells at day 14 (NK-14) were donor-derived, intensely proliferating and expressed chemokine receptors targeted to lymphoid and peripheral tissue...
September 25, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28944916/total-glucosides-of-paeony-ameliorates-tnbs%C3%A2-induced-colitis-by-modulating-differentiation-of-th17-treg-cells-and-the-secretion-of-cytokines
#3
Haihua Lin, Wenyou Zhang, Xuepei Jiang, Renpin Chen, Xielin Huang, Zhiming Huang
The imbalance between effector CD4+ T helper 17 (Th17) and regulatory CD4+ T cells (Treg) cells and their associated cytokines, have been associated with the pathogenesis of inflammatory bowel disease (IBD). Total glycosides of paeony (TGP) is an alternative immunomodulatory agent that is widely used for the treatment of autoimmune diseases. The present study aimed to evaluate the modulatory effect of TGP in a rat model of colitis induced by 2,4,6‑trinitrobenzene sulfonic acid (TNBS). TGP was administered intragastrically 24 h after the TNBS intrarectal instillation for 7 days...
September 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944907/placenta%C3%A2-derived-mesenchymal-stem-cells-improve-airway-hyperresponsiveness-and-inflammation-in-asthmatic-rats-by-modulating-the-th17-treg-balance
#4
Yingying Li, Hongbo Li, Yinyin Cao, Fuling Wu, Wenbin Ma, Yuesi Wang, Shuzhen Sun
Mesenchymal stem cells (MSCs) possess reparative and immunoregulatory properties, representing a hope for stem cell‑based treatments. However, the mechanisms by which transplanted MSCs affect T helper (Th)17/regulatory T cell (Treg) balance in asthma patients remain unclear. The aim of the present study was to assess the therapeutic effects of human placenta MSCs (hPMSCs) in asthma, and explore the underlying mechanisms; in addition, the impact of hPMSCs transplantation on Th17/Treg balance in lymph and serum samples from asthmatic animals was evaluated...
September 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944167/regulation-of-cytotoxic-t-cell-responses-by-p53-in-cancer
#5
Mitchell W Braun, Tomoo Iwakuma
An intriguing aspect of the tumor suppressor p53 is its ability to communicate to the adaptive immune system and control the cytotoxic T-lymphocyte (CTL) response to cancer cells. Wild-type p53 (wtp53) communicates with CTLs through proteins involved in the major histocompatibility complex (MHC) class I antigen presentation pathway [e.g., transporter associated with antigen processing 1 (TAP1) and endoplasmic reticulum amino peptidase 1 (ERAP1)], the apoptosis signal receptor Fas/APO-1, and the inhibitory immune-checkpoint programmed death-ligand 1 (PD-L1)...
December 2016: Translational Cancer Research
https://www.readbyqxmd.com/read/28943968/high-excision-repair-cross-complementation-group-1-expression-is-associated-with-favorable-prognostic-factors-in-breast-cancer
#6
Dong Hyun Kim, Hyunjoo Lee, Dong-Hoon Kim, Seoung Wan Chae, Jin Hee Sohn, Kyungeun Kim, Sung-Im Do
Distortion of DNA can inhibit transcription and replication, resulting in cell death. The nucleotide excision repair (NER) pathway recognizes and repairs DNA adducts. Excision repair cross-complementation group 1 (ERCC1) is a nuclease that serves a vital role in the NER pathway. Few studies have investigated ERCC1 expression in breast cancer. The aim of the present study was to analyze the association between clinicopathological features and ERCC1 expression in breast cancer. ERCC1 expression was studied in 224 invasive ductal carcinomas by immunohistochemical staining...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943905/screening-the-key-genes-of-hepatocellular-adenoma-via-microarray-analysis-of-dna-expression-and-methylation-profiles
#7
Dan Liu, Pengfei Liu, Liye Cao, Quan Zhang, Yaqing Chen
The aim of the present study was to identify the biomarkers involved in the development of hepatocellular adenoma (HCA) through integrated analysis of gene expression and methylation microarray. The microarray dataset GSE7473, containing HNF1α-mutated HCA and their corresponding non-tumor livers, 5 HNF1α-mutated HCA and 4 non-related non-tumor livers, was downloaded from the Gene Expression Omnibus (GEO) database. The DNA methylation profile GSE43091, consisting of 50 HCA and 4 normal liver tissues, was also downloaded from the GEO database...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943399/testosterone-bicalutamide-antagonism-at-the-predicted-extracellular-androgen-binding-site-of-zip9
#8
Ahmed Bulldan, Viveka Nand Malviya, Neha Upmanyu, Lutz Konrad, Georgios Scheiner-Bobis
ZIP9 is a Zn(2+) transporter, testosterone receptor, and mediator of signaling events through G-proteins. Despite these pivotal properties, however, its physiological and pathophysiological significance has not yet been comprehensively addressed. Using a cell line that lacks the classical androgen receptor we show that ZIP9-mediated phosphorylation of Erk1/2, CREB, or ATF-1 and expression of claudin-5 and zonula occludens-1 by testosterone can be completely antagonized by bicalutamide (Casodex), an anti-androgen of significant clinical impact...
September 21, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28942944/death-receptor-3-regulates-distinct-pathological-attributes-of-acute-versus-chronic-murine-allergic-lung-inflammation
#9
Ravinder Kaur Singh, William Victor Perks, Jason Peter Twohig, Emma J Kidd, Kenneth Broadley, Stuart N Farrow, Anwen Sian Williams, Philip Russel Taylor, Eddie Chung Yern Wang
The Death Receptor 3 (DR3)/Tumour Necrosis Factor-like cytokine 1A (TL1A) axis stimulates effector T cells and type 2 innate lymphocytes (ILC2) that trigger cytokine release and drive disease pathology in several inflammatory and autoimmune diseases, including murine models of acute allergic lung inflammation (ALI). The aim of this study was to elucidate the role of DR3 in chronic ALI compared to acute ALI, using mice genetically deficient in the DR3 gene (DR3(ko)). Results showed DR3 expression in the lungs of wild-type mice was up-regulated following induction of acute ALI and this increased expression was maintained in chronic disease...
September 15, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/28942919/organism-level-analysis-of-vaccination-reveals-networks-of-protection-across-tissues
#10
Motohiko Kadoki, Ashwini Patil, Cornelius C Thaiss, Donald J Brooks, Surya Pandey, Deeksha Deep, David Alvarez, Ulrich H von Andrian, Amy J Wagers, Kenta Nakai, Tarjei S Mikkelsen, Magali Soumillon, Nicolas Chevrier
A fundamental challenge in immunology is to decipher the principles governing immune responses at the whole-organism scale. Here, using a comparative infection model, we observe immune signal propagation within and between organs to obtain a dynamic map of immune processes at the organism level. We uncover two inter-organ mechanisms of protective immunity mediated by soluble and cellular factors. First, analyzing ligand-receptor connectivity across tissues reveals that type I IFNs trigger a whole-body antiviral state, protecting the host within hours after skin vaccination...
September 4, 2017: Cell
https://www.readbyqxmd.com/read/28942847/identification-and-preliminary-characterization-of-a-putative-c-type-lectin-receptor-like-protein-in-the-t-cruzi-tomato-lectin-endocytic-enriched-proteome
#11
Sébastien Brosson, Guy Bottu, Etienne Pays, Sabrina Bousbata, Didier Salmon
Trypanosoma cruzi, the etiological agent of the Chagas' disease in Latin America undergoes a complex life cycle involving two hosts, a mammalian host and a reduviid insect vector (triatomine). In the insect midgut the parasite multiplies as epimastigote forms, which rely on endocytosis for their energy requirement. We recently showed that posttranslational modification of endocytic N-glycoproteins by tomato lectin (TL) binding-N-glycans is crucial for receptor-mediated endocytosis (RME) in epimastigote forms...
December 2017: Microbiological Research
https://www.readbyqxmd.com/read/28942366/t-regulatory-cells-mediate-local-immunosuppression-in-lymphedema
#12
Gabriela D García Nores, Catherine L Ly, Ira L Savetsky, Raghu P Kataru, Swapna Ghanta, Geoffrey E Hespe, Stanley G Rockson, Babak J Mehrara
Patients who suffer from lymphedema have impaired immunity and, as a result, are at an increased risk for infections. Furthermore, previous studies have shown that lymphadenectomy impairs acquisition of adaptive immune responses and antibody production in response to foreign antigens. Although it is clear that antigen presentation in lymph nodes plays a key role in adaptive immunity, the cellular mechanisms that regulate impaired immune responses in patients with lymphedema or following lymphatic injury remain unknown...
September 20, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28942102/skov3-cells-containing-a-truncated-arid1a-protein-have-a-restricted-genome-wide-response-to-glucocorticoids
#13
F E Stubbs, M T Birnie, S C Biddie, S L Lightman, B L Conway-Campbell
AT-rich interacting domain subunit 1a (ARID1a) is an essential SWI/SNF component frequently mutated in human cancers. ARID1a mutations have also been associated with glucocorticoid resistance, potentially related to the well-established role of the SWI/SNF complex in glucocorticoid target gene regulation. Glucocorticoids are steroid hormones important for regulating many physiological processes through the activation of the glucocorticoid receptor (GR). As GR interacts directly with ARID1a, we hypothesized that a truncating ARID mutation would interfere with GR-dependent gene regulation...
September 20, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28942035/putative-role-of-kir3dl1-3ds1-alleles-and-hla-bw4-ligands-with-end-stage-renal-disease-and-long-term-renal-allograft-survival
#14
Swayam Prakash, Aditya Narayan Sarangi, Shahnawaz Alam, Avinash Sonawane, Raj Kumar Sharma, Suraksha Agrawal
BACKGROUND: Killer immunoglobulin receptors (KIR) are highly polymorphic in nature. KIR3DL1/3DS1 genes are known to affect HLA-B antigen binding affinity causing natural killer (NK) cell inhibition, which results into successful renal transplantation. In this study we have examined whether alleles of KIR3DL1/3DS1 play any role in changing the binding affinity with HLA-Bw4 antigen and if so then how are they associated with long term renal allograft survival. We have also evaluated plausible association of KIR3DL1 with HLA-A23/A24/A32 with renal pathophysiology...
September 20, 2017: Gene
https://www.readbyqxmd.com/read/28941938/design-synthesis-and-biological-evaluation-of-8-substituted-6-hydrazonoindolo-2-1-b-quinazolin-12-6h-one-scaffolds-as-potential-cytotoxic-agents-ido-1-targeting-molecular-docking-studies
#15
Ramu Guda, Rajashekar Korra, Siripireddy Balaji, Rambabu Palabindela, Rakesh Eerla, Harikiran Lingabathula, Narsimha Reddy Yellu, Girijesh Kumar, Mamatha Kasula
Herein, we have reported the synthesis of 18 novel 8-substituted tryptanthrin analogues based on our earlier work. All these tryptanthrin analogues were well characterized by (1)H &(13)C NMR, FT-IR, Mass Spectrometry and Elemental Analysis. All these 8-substituted analogues were screened for their anti-oxidant activity by DPPH radical scavenging assay. Out of all the tested compounds, T(11), T(12), T(17) and T(18) showed potent anti-oxidant activity. The anti-cancer activity have been performed by using MTT assay protocol and their results depicts that compounds having the 4-pyridyl or 4-carboxyphenyl substituents at the 8th position of the tryptanthrin framework are found to be the most promising cytotoxic agent against A549, MCF-7 and HeLa human cancer cell lines compared to others as well as with the standard drug cisplatin...
September 1, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28941625/a-yin-and-yang-in-epithelial-immunology-the-roles-of-the-%C3%AE-e-cd103-%C3%AE-7-integrin-in%C3%A2-t%C3%A2-cells
#16
REVIEW
Jan-Hendrik B Hardenberg, Andrea Braun, Michael P Schön
The proper function(s) of cell-surface receptors is crucial for the regulation of adaptive immune responses. One such receptor is the αE(CD103)β7 integrin, whose history in science is closely linked with the evolution of our knowledge of immune regulation. Initially described as a marker of intraepithelial T-lymphocytes, this leukocyte integrin is now seen as a dynamically regulated receptor involved in the functional differentiation of some cytotoxic T cells as well as regulatory T cells, thus presumably contributing to the fine-tuning of immune reactions in epithelial compartments...
September 20, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28941492/replenishing-regulatory-t-cells-to-halt%C3%A2-depigmentation-in-vitiligo
#17
REVIEW
I Caroline Le Poole, Shikhar Mehrotra
Vitiligo is a cutaneous autoimmune disease, especially devastating to patients with darker skin tones because of the contrast between unaffected and lesional skin. We studied immune cells infiltrating vitiligo skin and found very few regulatory T cells (Tregs). Vitiligo was not associated with a reduced frequency or function of circulating Tregs. To manipulate Treg function, we used mouse models expressing melanocyte-reactive TCRs, following changes in pelage color. We also isolated splenocytes to measure Treg function and evaluated cutaneous Treg abundance...
October 2017: Journal of Investigative Dermatology. Symposium Proceedings
https://www.readbyqxmd.com/read/28941475/melanocytes-target-cells-of-an-hla-c-06-02-restricted-autoimmune-response-in-psoriasis
#18
REVIEW
Jörg Christoph Prinz
HLA-C*06:02 is the main psoriasis risk allele. By the unbiased analysis of a Vα3S1/Vβ13S1 T-cell receptor from pathogenic psoriatic CD8(+) T cells, we had recently proven that HLA-C*06:02 directs an autoimmune response against melanocytes through autoantigen presentation in psoriasis and identified ADAMTSL5 as a melanocyte autoantigen. We concluded that psoriasis is based on a melanocyte-specific immune response and that HLA-C*06:02 may predispose to psoriasis via this newly identified autoimmune pathway...
October 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28941464/glutamic-acid-as-enhancer-of-protein-synthesis-kinetics-in-hepatocytes-from-old-rats
#19
V Y Brodsky, L A Malchenko, N N Butorina, D S Lazarev Konchenko, N D Zvezdina, T K Dubovaya
Dense cultures of hepatocytes from old rats (~2 years old, body weight 530-610 g) are different from similar cultures of hepatocytes from young rats by the low amplitude of protein synthesis rhythm. Addition of glutamic acid (0.2, 0.4, or 0.6 mg/ml) into the culture medium with hepatocytes of old rats resulted in increase in the oscillation amplitudes of the protein synthesis rhythm to the level of young rats. A similar action of glutamic acid on the protein synthesis kinetics was observed in vivo after feeding old rats with glutamic acid...
August 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28940700/therapeutic-inhibition-of-inflammatory-monocyte-recruitment-reduces-steatohepatitis-and-liver-fibrosis
#20
Oliver Krenkel, Tobias Puengel, Olivier Govaere, Ali T Abdallah, Jana C Mossanen, Marlene Kohlhepp, Anke Liepelt, Eric Lefebvre, Tom Luedde, Claus Hellerbrand, Ralf Weiskirchen, Thomas Longerich, Ivan G Costa, Quentin M Anstee, Christian Trautwein, Frank Tacke
Macrophages are key regulators of liver fibrosis progression and regression in nonalcoholic steatohepatitis (NASH). Liver macrophages comprise resident phagocytes, Kupffer cells, and monocyte-derived cells, which are recruited via the chemokine receptor CCR2. We aimed at elucidating the therapeutic effects of inhibiting monocyte infiltration in NASH models by using cenicriviroc (CVC), an oral dual chemokine receptor CCR2/CCR5 antagonist that is under clinical evaluation. Human liver tissue from NASH patients were analyzed for CCR2+ macrophages and administration of CVC was tested in mouse models of steatohepatitis, liver fibrosis progression and fibrosis regression...
September 21, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
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