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High Altitude Pulmonary Edema

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https://www.readbyqxmd.com/read/28910201/reentry-high-altitude-pulmonary-edema-in-the-himalayas
#1
Santosh Baniya, Christopher Holden, Buddha Basnyat
Baniya, Santosh, Christopher Holden, and Buddha Basnyat. Reentry high altitude pulmonary edema in the Himalayas. High Alt Med Biol. 16:000-000, 2017.-Reentry high altitude pulmonary edema (HAPE), a subset of HAPE, is a well recognized, life-threatening illness documented almost exclusively in the North and South Americans, who live at high altitude (>2500 m) and return to their homes after a brief sojourn of days to months at lower altitude. This phenomenon has not been reported in Sherpas or other people of Tibetan origin in Nepal or India...
September 14, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28876136/electron-microscopy-observation-of-human-pulmonary-ultrastructure-in-two-patients-with-high-altitude-pulmonary-edema
#2
Yunden Droma, Akane Kato, Takashi Ichiyama, Nobumitsu Kobayashi, Takayuki Honda, Takeshi Uehara, Masayuki Hanaoka
We examined the pulmonary ultrastructure in tissue from two patients with high-altitude pulmonary edema (HAPE) by electron microscopy. In one case, we found that neutrophils were trapped in pulmonary capillary lumen of alveolar-capillary wall and part of the cytoplasm of a neutrophil protruded and adhered to the capillary endothelium. There were several degranulated vacuoles in the cytoplasm of the neutrophil. The pulmonary capillary wall was deformed, thickened, and swollen and there was evidence of degeneration...
September 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28846035/high-altitude-pulmonary-edema-in-mountain-community-residents
#3
Christine Ebert-Santos
Ebert-Santos, Christine. High-altitude pulmonary edema in mountain community residents. High Alt Med Biol. 18:278-284, 2017.-High-altitude pulmonary edema (HAPE) affects lowlanders ascending quickly to elevations above 2440 m. Mountain resident children with no travel can sometimes develop HAPE as was observed over 30 years ago (Fasules et al., 1985). This is not well known and children instead are diagnosed as having pneumonia or asthma. In our clinic at 2800 m, we see children presenting with severe hypoxemia, clinical, and radiographic findings consistent with HAPE despite no recent travel...
September 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28837781/reply-unilateral-pulmonary-edema-after-visiting-high-altitude
#4
Sujith V Cherian, Rosa M Estrada-Y-Martin
N/A.
August 24, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28837778/unilateral-high-altitude-pulmonary-edema
#5
Giuseppe Fiorenzano, Maurizio Dottorini
No abstract text is available yet for this article.
September 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28798201/remote-ischemic-preconditioning-does-not-prevent-acute-mountain-sickness-after-rapid-ascent-to-3450-m
#6
Marc M Berger, Franziska Macholz, Lukas Lehmann, Daniel Dankl, Marcel Hochreiter, Bernhard Bacher, Peter Bärtsch, Heimo Mairbäurl
Remote ischemic preconditioning (RIPC) has been shown to protect remote organs, such as the brain and the lung, from damage induced by subsequent hypoxia or ischemia. Acute mountain sickness (AMS) is a syndrome of non-specific neurologic symptoms and in high altitude pulmonary edema excessive hypoxic pulmonary vasoconstriction (HPV) plays a pivotal role. We hypothesized that RIPC protects the brain from AMS and attenuates the magnitude of HPV after rapid ascent to 3450 m. Forty non-acclimatized volunteers were randomized into 2 groups...
August 10, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28781177/impact-of-a-newly-constructed-motor-vehicle-road-on-altitude-illness-in-the-nepal-himalayas
#7
Jonathan Reisman, Dinesh Deonarain, Buddha Basnyat
OBJECTIVE: This study investigated the impact that motor vehicle travel along a newly constructed road has on altitude illness (including acute mountain sickness, high-altitude cerebral edema, and high-altitude pulmonary edema). The new road from Besisahar (760 m) to Manang (3540 m) in Nepal was completed in December 2014. METHODS: We enrolled all patients diagnosed with altitude illness at the Himalayan Rescue Association Manang clinic in fall 2016. Phi coefficients were calculated to test for an association between Nepali ethnicity and rapid ascent by motor vehicle...
August 3, 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28673745/high-altitude-pulmonary-edema-in-a-mining-worker-with-an-abnormal-rise-in-pulmonary-artery-pressure-in-response-to-acute-hypoxia-without-prior-history-of-high-altitude-pulmonary-edema
#8
Almaz Ch Akunov, Meerim A Sartmyrzaeva, Abdirashit M Maripov, Kubatbek Muratali Uulu, Argen T Mamazhakypov, Akylbek S Sydykov, Akpay Sh Sarybaev
High altitude pulmonary edema (HAPE) is a potentially life-threatening form of noncardiogenic pulmonary edema that may develop in otherwise healthy individuals upon ascent to high altitude. A constitutional susceptibility has been noted in some individuals, whereas others appear not to be susceptible at all. In our report, we present a case of HAPE triggered by concurrent respiratory tract infection and strenuous exercise in a mining worker with an abnormal rise in pulmonary artery pressure in response to acute hypoxia, without a prior history of HAPE during almost a year of commuting between high altitude and lowland areas...
June 30, 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28590162/exercise-testing-supplemental-oxygen-and-hypoxia
#9
Susan A Ward, Michael P W Grocott, Denny Z H Levett
Cardiopulmonary exercise testing (CPET) in hyperoxia and hypoxia has several applications, stemming from characterization of abnormal physiological response profiles associated with exercise intolerance. As altered oxygenation can impact the performance of gas-concentration and flow sensors and pulmonary gas exchange algorithms, integrated CPET system function requires validation under these conditions. Also, as oxygenation status can influence peak [Formula: see text]o2, care should be taken in the selection of work-rate incrementation rates when CPET performance is to be compared with normobaria at sea level...
July 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28415562/genome-wide-association-study-of-high-altitude-pulmonary-edema-in-a-han-chinese-population
#10
Xun Li, Tianbo Jin, Mingxia Zhang, Hua Yang, Xuewen Huang, Xiaobo Zhou, Wenchao Huang, Lipeng Qin, Longli Kang, Ming Fan, Suzhi Li
A two-stage genome-wide association study (GWAS) was performed to identify and analyze genes and single nucleotide polymorphisms (SNPs) associated with high-altitude pulmonary edema (HAPE) in a Han Chinese patient population. In the first stage, DNA samples from 68 patients with recurrent HAPE were scanned using Affymetrix SNP Array 6.0 Chips, and allele frequencies were compared to those of 84 HapMap CHB samples to identify candidate SNPs. In the second stage, the 77 identified candidate SNPs were examined in an independent cohort of samples from 199 HAPE patients and 304 controls...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28411926/advances-in-the-prevention-and-treatment-of-high-altitude-illness
#11
REVIEW
Christopher Davis, Peter Hackett
High altitude illness encompasses a spectrum of clinical entities to include: acute mountain sickness, high altitude cerebral edema, and high altitude pulmonary edema. These illnesses occur as a result of a hypobaric hypoxic environment. Although a mild case of acute mountain sickness may be self-limited, high altitude cerebral edema and high altitude pulmonary edema represent critical emergencies that require timely intervention. This article reviews recent advances in the prevention and treatment of high altitude illness, including new pharmacologic strategies for prophylaxis and revised treatment guidelines...
May 2017: Emergency Medicine Clinics of North America
https://www.readbyqxmd.com/read/28398844/breathlessness-at-high-altitude-first-episode-of-bronchoconstriction-in-an-otherwise-healthy-sojourner
#12
Sanjeeb Sudarshan Bhandari, Pranawa Koirala, Sadichhya Lohani, Pratibha Phuyal, Buddha Basnyat
Bhandari, Sanjeeb Sudarshan, Pranawa Koirala, Sadichhya Lohani, Pratibha Phuyal, and Buddha Basnyat. Breathlessness at high altitude: first episode of bronchoconstriction in an otherwise healthy sojourner. High Alt Med Biol.. 18:179-181, 2017-High-altitude illness is a collective term for less severe acute mountain sickness and more severe high-altitude pulmonary edema (HAPE) and high-altitude cerebral edema, which we can experience while traveling to high altitude. These get better when we get down to the lower altitudes...
June 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28362866/thoraco-abdominal-coordination-and-performance-during-uphill-running-at-altitude
#13
Eva Bernardi, Lorenza Pratali, Gaia Mandolesi, Maria Spiridonova, Giulio Sergio Roi, Annalisa Cogo
INTRODUCTION: Running races on mountain trails at moderate-high altitude with large elevation changes throughout has become increasingly popular. During exercise at altitude, ventilatory demands increase due to the combined effects of exercise and hypoxia. AIM: To investigate the relationships between thoraco-abdominal coordination, ventilatory pattern, oxygen saturation (SpO2), and endurance performance in runners during high-intensity uphill exercise. METHODS: Fifteen participants (13 males, mean age 42±9 yrs) ran a "Vertical Kilometer," i...
2017: PloS One
https://www.readbyqxmd.com/read/28362529/unilateral-pulmonary-edema-after-visiting-high-altitude
#14
Sujith V Cherian, Rosa M Estrada-Y-Martin
No abstract text is available yet for this article.
April 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28353602/association-between-genetic-polymorphism-of-telomere-associated-gene-acyp2-and-the-risk-of-hape-among-the-chinese-han-population-a-case-control-study
#15
Linhao Zhu, Lijun Liu, Xue He, Mengdan Yan, Jieli Du, Hua Yang, Yuan Zhang, Dongya Yuan, Tianbo Jin
High-altitude pulmonary edema (HAPE) is a hypoxia-induced, life-threatening, pulmonary edema, which is characterized by exaggerated pulmonary hypertension caused by stress failure. ACYP2 was found to associated with telomere length, the aim of this study was to identify whether ACYP2 polymorphisms increase or decrease HAPE risk in the Chinese Han individuals.In present study, we have genotyped 7 single-nucleotide polymorphisms (SNPs) in ACYP2 to determine the haplotypes in a case-control study with 265 HAPE patients and 303 healthy individuals...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28285976/high-altitude-illness-in-pilgrims-after-rapid-ascent-to-4380%C3%A2-m
#16
Ken Zafren, Matiram Pun, Nirajan Regmi, Gobinda Bashyal, Bhuwan Acharya, Subarna Gautam, Sujan Jamarkattel, Shankar Raj Lamichhane, Suman Acharya, Buddha Basnyat
BACKGROUND: The goal of the study was to characterize high altitude illness in Nepali pilgrims. METHODS: We kept standardized records at the Himalayan Rescue Association (HRA) Temporary Health Camp at Gosainkund Lake (4380 m) in the Nepal Himalaya during the annual Janai Purnima Festival in 2014. Records included rate of ascent and Lake Louise Score (LLS). We defined High Altitude Headache (HAH) as headache alone or LLS = 2. Acute Mountain Sickness (AMS) was LLS≥3...
March 9, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/28270701/comment-on-soluble-urokinase-type-plasminogen-activator-receptor-plasma-concentration-may-predict-susceptibility-to-high-altitude-pulmonary-edema
#17
COMMENT
Gaurav Sikri, Srinivasa Bhattachar
No abstract text is available yet for this article.
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28257713/hmox1-promoter-microsatellite-polymorphism-is-not-associated-with-high-altitude-pulmonary-edema-in-han-chinese
#18
Xue-Feng Cao, Lan Ma, Shang Ma, Jin Xu, Ri-Li Ge
OBJECTIVE: To investigate the relationship between microsatellite polymorphism in the Heme oxygenase-1 (HMOX1) gene promoter and high-altitude pulmonary edema (HAPE) in Han Chinese. METHODS: Eighty-three construction workers who developed HAPE 2 to 7 days after arrival at Yushu (3800 m) in Qinghai, China, and 145 matched healthy subjects were included in this study. The amplification and labeling of the polymerase chain reaction products for capillary electrophoresis were performed to identify HMOX1 genotype frequency...
March 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28242600/the-susceptibility-gene-screening-in-a-chinese-high-altitude-pulmonary-edema-family-by-whole-exome-sequencing
#19
Ying-zhong Yang, Ya-ping Wang, Jin Xu, Ri-li Ge
High-altitude pulmonary edema (HAPE) is one of idiopathic mountain sicknesses that occur in healthy lowlanders when they quickly ascend to altitudes exceeding 2500 m above sea levels within 1-7 days. Growing evidence suggests that genetics plays an important role in the risk of HAPE. In this study, we recruited a Chinese HAPE family and screened genetic variations in the 7 family members (including 6 family members with a medical history of HAPE and the propositus's mother) by whole-exome sequencing. The results showed 18 genetic variations (9 SNVs and 9 Indels) were related to HAPE...
February 20, 2017: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/28235856/exploring-new-heights-with-pulmonary-functional-imaging-insights-into-high-altitude-pulmonary-edema
#20
Sean B Fain, Marlowe W Eldridge
N/A.
February 23, 2017: Journal of Applied Physiology
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