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https://www.readbyqxmd.com/read/28822036/filling-the-gaps-in-the-classification-of-the-digenea-carus-1863-systematic-position-of-the-proterodiplostomidae-dubois-1936-within-the-superfamily-diplostomoidea-poirier-1886-inferred-from-nuclear-and-mitochondrial-dna-sequences
#1
David Iván Hernández-Mena, Martín García-Varela, Gerardo Pérez-Ponce de León
The Diplostomida Olson, Cribb, Tkach, Bray & Littlewood, 2003 is the less diverse order of the two orders within the subclass Digenea Carus, 1863 and is currently classified into three superfamilies, i.e. Brachylaimoidea Joyeux & Foley, 1930, Diplostomoidea Poirier, 1886, and Schistosomatoidea Stiles & Hassall, 1898. Although the suprageneric-level relationships have been elucidated with the use of molecular markers, the lack of representation of some groups obscure the phylogenetic relationships among families, rendering the classification unstable...
August 18, 2017: Systematic Parasitology
https://www.readbyqxmd.com/read/28821866/detection-of-magnetized-quark-nuggets-a-candidate-for-dark-matter
#2
J Pace VanDevender, Aaron P VanDevender, T Sloan, Criss Swaim, Peter Wilson, Robert G Schmitt, Rinat Zakirov, Josh Blum, James L Cross, Niall McGinley
Quark nuggets are theoretical objects composed of approximately equal numbers of up, down, and strange quarks and are also called strangelets and nuclearites. They have been proposed as a candidate for dark matter, which constitutes ~85% of the universe's mass and which has been a mystery for decades. Previous efforts to detect quark nuggets assumed that the nuclear-density core interacts directly with the surrounding matter so the stopping power is minimal. Tatsumi found that quark nuggets could well exist as a ferromagnetic liquid with a ~10(12)-T magnetic field...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821768/real-time-monitoring-of-water-level-and-temperature-in-storage-fuel-pools-through-optical-fibre-sensors
#3
S Rizzolo, J Périsse, A Boukenter, Y Ouerdane, E Marin, J-R Macé, M Cannas, S Girard
We present an innovative architecture of a Rayleigh-based optical fibre sensor for the monitoring of water level and temperature inside storage nuclear fuel pools. This sensor, able to withstand the harsh constraints encountered under accidental conditions such as those pointed-out during the Fukushima-Daiichi event (temperature up to 100 °C and radiation dose level up to ~20 kGy), exploits the Optical Frequency Domain Reflectometry technique to remotely monitor a radiation resistant silica-based optical fibre i...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821709/assessment-of-the-announced-north-korean-nuclear-test-using-long-range-atmospheric-transport-and-dispersion-modelling
#4
Pieter De Meutter, Johan Camps, Andy Delcloo, Piet Termonia
On 6 January 2016, the Democratic People's Republic of Korea announced to have conducted its fourth nuclear test. Analysis of the corresponding seismic waves from the Punggye-ri nuclear test site showed indeed that an underground man-made explosion took place, although the nuclear origin of the explosion needs confirmation. Seven weeks after the announced nuclear test, radioactive xenon was observed in Japan by a noble gas measurement station of the International Monitoring System. In this paper, atmospheric transport modelling is used to show that the measured radioactive xenon is compatible with a delayed release from the Punggye-ri nuclear test site...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821316/obesity-and-fatty-liver-are-prevented-by-inhibition-of-the-aryl-hydrocarbon-receptor-in-both-female-and-male-mice
#5
Benjamin J Moyer, Itzel Y Rojas, Joanna S Kerley-Hamilton, Krishnamurthy V Nemani, Heidi W Trask, Carol S Ringelberg, Barjor Gimi, Eugene Demidenko, Craig R Tomlinson
Inhibition of the aryl hydrocarbon receptor (AHR) prevents Western diet-induced obesity and fatty liver in C57Bl/6J (B6) male mice. The AHR is a ligand-activated nuclear receptor that regulates genes involved in xenobiotic metabolism and T-cell differentiation. Here, we tested the hypothesis that AHR antagonism would also prevent obesity and fatty liver in female mice and that B6 mice (higher-affinity AHR) and congenic B6.D2 mice (lower-affinity AHR) would differentially respond to AHR inhibition. Female and male adult B6 and B6...
August 2017: Nutrition Research
https://www.readbyqxmd.com/read/28821229/mechanisms-of-peripheral-phylogeographic-divergence-in-the-indo-pacific-lessons-from-the-spiny-lobster-panulirus-homarus
#6
Ahmad Farhadi, Andrew G Jeffs, Hamid Farahmand, Thankappan Sarasam Rejiniemon, Greg Smith, Shane D Lavery
BACKGROUND: There is increasing recognition of the concordance between marine biogeographic and phylogeographic boundaries. However, it is still unclear how population-level divergence translates into species-level divergence, and what are the principal factors that first initiate that divergence, and then maintain reproductive isolation. This study examines the likely forces driving population and lineage divergences in the broadly-distributed Indo-Pacific spiny lobster Panulirus homarus, which has peripheral divergent lineages in the west and east...
August 18, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28821228/sg-adviser-mtdna-a-web-server-for-mitochondrial-dna-annotation-with-data-from-200-samples-of-a-healthy-aging-cohort
#7
Manuel Rueda, Ali Torkamani
BACKGROUND: Whole genome and exome sequencing usually include reads containing mitochondrial DNA (mtDNA). Yet, state-of-the-art pipelines and services for human nuclear genome variant calling and annotation do not handle mitochondrial genome data appropriately. As a consequence, any researcher desiring to add mtDNA variant analysis to their investigations is forced to explore the literature for mtDNA pipelines, evaluate them, and implement their own instance of the desired tool. This task is far from trivial, and can be prohibitive for non-bioinformaticians...
August 18, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28821142/manufacture-of-requeij%C3%A3-o-cremoso-processed-cheese-with-galactooligosaccharide
#8
P C Belsito, M V S Ferreira, L P Cappato, R N Cavalcanti, V A S Vidal, T C Pimentel, E A Esmerino, C F Balthazar, R P C Neto, M I B Tavares, P B Zacarchenco, M Q Freitas, M C Silva, R S L Raices, G M Pastore, M A R Pollonio, A G Cruz
The addition of galactooligosaccharide, (GOS, 0, 1.5, 3 or 4g/100g) on the quality parameters of requeijão cremoso was investigated. Chemical characteristics (pH, moisture, fat and protein), color (L*, a*, b*), water mobility by TD- nuclear magnetic resonance, rheology (flow curve and oscillatory tests), microstructure and sensory acceptance (consumer test) were evaluated. The addition of GOS provided a denser and compact structure and reduced number and size of fat globules. Increased GOS level (3 and 4g/100g) improved the softness and spreadability (decrease of G', G″ and apparent viscosity and an increase of tan δ and melting index) and impacted positively on the aroma and taste of the requeijão cremoso...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28821132/the-effect-of-%C3%AE-cyclodextrin-on-poly-pseudo-rotaxane-nanoparticles-self-assembled-by-protoporphyrin-modified-poly-ethylene-glycol-for-anticancer-drug-delivery
#9
Taotao Xu, Junhua Li, Jun Cao, Wenxia Gao, Li Li, Bin He
Poly(pseudo)rotaxane (PPR) nanoparticles was facilely prepared using poly(ethylene glycol) (PEG) modified with protoporphyrin (PpIX) and α-cyclodextrin (α-CD) via host-guest interaction, the effect of α-CD number on the nanoparticle properties was investigated. The PEG with protoporphyrin (PEG-PpIX) end capping was synthesized via coupling reaction and the poly(pseudo)rotaxane nanoparticles with different amount of α-CD were fabricated by host-guest interaction between mPEG-PpIX and α-CDs. The final product was characterized by nuclear magnetic spectrum ((1)H NMR), X-ray diffraction (XRD), atomic force microscope (AFM) and dynamic light scattering (DLS)...
October 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28820735/the-use-of-sirna-as-a-pharmacological-tool-to-assess-a-role-for-the-transcription-factor-nf-il6-in-the-brain-under-in-vitro-and-in-vivo-conditions-during-lps-induced-inflammatory-stimulation
#10
Jelena Damm, Joachim Roth, Rüdiger Gerstberger, Christoph Rummel
BACKGROUND: Studies with NF-IL6-deficient mice indicate that this transcription factor plays a dual role during systemic inflammation with pro- and anti-inflammatory capacities. Here, we aimed to characterize the role of NF-IL6 specifically within the brain. METHODS: In this study, we tested the capacity of short interfering (si) RNA to silence the inflammatory transcription factor nuclear factor-interleukin 6 (NF-IL6) in brain cells under in vitro and in vivo conditions...
August 18, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28819745/bioassessment-of-the-effluents-discharged-from-two-export-oriented-industrial-zones-located-in-kelani-river-basin-sri-lanka-using-erythrocytic-responses-of-the-fish-nile-tilapia-oreochromis-niloticus
#11
C K Hemachandra, A Pathiratne
Complex effluents originating from diverse industrial processes in industrial zones could pose cytotoxic/genotoxic hazards to biota in the receiving ecosystems which cannot be revealed by conventional monitoring methods. This study assessed potential cytotoxicity/genotoxicity of treated effluents of two industrial zones which are discharged into Kelani river, Sri Lanka combining erythrocytic abnormality tests and comet assay of the tropical model fish, Nile tilapia. Exposure of fish to the effluents induced erythrocytic DNA damage and deformed erythrocytes with serrated membranes, vacuolations, nuclear buds and micronuclei showing cytotoxic/genotoxic hazards in all cases...
August 17, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28819641/in-search-of-multipath-interference-using-large-molecules
#12
Joseph P Cotter, Christian Brand, Christian Knobloch, Yigal Lilach, Ori Cheshnovsky, Markus Arndt
The superposition principle is fundamental to the quantum description of both light and matter. Recently, a number of experiments have sought to directly test this principle using coherent light, single photons, and nuclear spin states. We extend these experiments to massive particles for the first time. We compare the interference patterns arising from a beam of large dye molecules diffracting at single, double, and triple slit material masks to place limits on any high-order, or multipath, contributions. We observe an upper bound of less than one particle in a hundred deviating from the expectations of quantum mechanics over a broad range of transverse momenta and de Broglie wavelength...
August 2017: Science Advances
https://www.readbyqxmd.com/read/28819076/-molecularly-targeted-therapy-of-spinocerebellar-ataxia-type-1-by-hmgb1
#13
Kyota Fujita, Hitoshi Okazawa
Spinocerebellar ataxia type 1 (SCA1) is an untreatable neurodegenerative disease. We reported a decrease in HMGB1 levels in the nucleus of cerebellar neurons in mouse SCA 1. The decrease in this DNA architectural protein leads to the impairment of DNA repair and transcription, the two essential nuclear functions, and eventually causes neurodegeneration. We have designed a gene therapy using AAV-HMGB1 and tested it using the mouse model. Based on the results of these proof of concept (POC) studies, we are now preparing GMP-level AAV vector and designing human clinical trials...
August 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28818779/in-vitro-culture-responses-callus-growth-and-organogenetic-potential-of-brinjal-solanum-melongena-l-to-he-ne-laser-irradiation
#14
Puthanvila Surendrababu Swathy, Gogia Rupal, Vijendra Prabhu, Krishna Kishore Mahato, Annamalai Muthusamy
The present investigation was designed to analyze the influence of Helium-Neon (He-Ne 632.8nm) laser irradiation on defense enzymes, proline content and in vitro responses of callus induction, shoot initiation and on plantlet regeneration potential of brinjal. The seeds of Mattu Gulla (Solanum melongena L.) were irradiated with 20, 25 and 30J/cm(2) of He-Ne laser followed by surface sterilization and sprouted on Murashige and Skoog medium without plant growth regulators. The activity of defense enzymes, proline content and the organogenetic potential of hypocotyl, leaf and shoot tip explants were determined from thirty day old seedlings...
August 10, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28818645/improved-performance-comparisons-of-radioxenon-systems-for-low-level-releases-in-nuclear-explosion-monitoring
#15
Derek A Haas, Paul W Eslinger, Theodore W Bowyer, Ian M Cameron, James C Hayes, Justin D Lowrey, Harry S Miley
The Comprehensive Nuclear-Test-Ban Treaty bans all nuclear tests and mandates development of verification measures to detect treaty violations. One verification measure is detection of radioactive xenon isotopes produced in the fission of actinides. The International Monitoring System (IMS) currently deploys automated radioxenon systems that can detect four radioxenon isotopes. Radioxenon systems with lower detection limits are currently in development. Historically, the sensitivity of radioxenon systems was measured by the minimum detectable concentration for each isotope...
August 14, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28818566/a-synthetic-human-cytomegalovirus-pp65-ie1-fusion-antigen-efficiently-induces-and-expands-virus-specific-t-cells
#16
Ellen K Link, Christine Brandmüller, Yasemin Suezer, Stefanie Ameres, Asisa Volz, Andreas Moosmann, Gerd Sutter, Michael H Lehmann
Infection with human cytomegalovirus (HCMV) can cause severe complications in newborns and immunocompromised patients, and a prophylactic or therapeutic vaccine against HCMV is not available. Here, we generated a HCMV vaccine candidate fulfilling the regulatory requirements for GMP-compliant production and clinical testing. A novel synthetic fusion gene consisting of the coding sequences of HCMV pp65 and IE1 having a deleted nuclear localization sequence and STAT2 binding domain was introduced into the genome of the attenuated vaccinia virus strain MVA...
August 14, 2017: Vaccine
https://www.readbyqxmd.com/read/28813576/joint-analysis-of-nuclear-and-mitochondrial-variants-in-age-related-macular-degeneration-identifies-novel-loci-trpm1-and-abhd2-rlbp1
#17
Patrice J Persad, Iris M Heid, Daniel E Weeks, Paul N Baird, Eiko K de Jong, Jonathan L Haines, Margaret A Pericak-Vance, William K Scott
Purpose: Presently, 52 independent nuclear single nucleotide polymorphisms (nSNPs) have been associated with age-related macular degeneration (AMD) but their effects do not explain all its variance. Genetic interactions between the nuclear and mitochondrial (mt) genome may unearth additional genetic loci previously unassociated with AMD risk. Methods: Joint effects of nSNPs and selected mtSNPs were analyzed by two degree of freedom (2df) joint tests of association in the International AMD Genomics Consortium (IAMDGC) dataset (17,832 controls and 16,144 advanced AMD cases of European ancestry)...
August 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28813561/comparison-of-coronary-ct-angiography-spect-pet-and-hybrid-imaging-for-diagnosis-of-ischemic-heart-disease-determined-by-fractional-flow-reserve
#18
Ibrahim Danad, Pieter G Raijmakers, Roel S Driessen, Jonathon Leipsic, Rekha Raju, Chris Naoum, Juhani Knuuti, Maija Mäki, Richard S Underwood, James K Min, Kimberly Elmore, Wynand J Stuijfzand, Niels van Royen, Igor I Tulevski, Aernout G Somsen, Marc C Huisman, Arthur A van Lingen, Martijn W Heymans, Peter M van de Ven, Cornelis van Kuijk, Adriaan A Lammertsma, Albert C van Rossum, Paul Knaapen
Importance: At present, the choice of noninvasive testing for a diagnosis of significant coronary artery disease (CAD) is ambiguous, but nuclear myocardial perfusion imaging with single-photon emission tomography (SPECT) or positron emission tomography (PET) and coronary computed tomography angiography (CCTA) is predominantly used for this purpose. However, to date, prospective head-to-head studies are lacking regarding the diagnostic accuracy of these imaging modalities. Furthermore, the combination of anatomical and functional assessments configuring a hybrid approach may yield improved accuracy...
August 16, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28811895/long-term-rearrangement-of-retinal-structures-in-a-novel-mutation-of-x-linked-retinoschisis
#19
Stefano Piermarocchi, Stefania Miotto, Davide Colavito, Elda Del Giudice, Alberta Leon, Veronica Maritan, Rita Piermarocchi, Alma Patrizia Tormene
The aim of the present study was to report a novel mutation in the retinoschisin 1 (RS1) gene in a Caucasian family affected by X-linked juvenile retinoschisis (XLRS) and to describe the long-term modification of retinal structure. Two brothers with an early onset maculopathy were diagnosed with XLRS. Fundus photography, fluorescein angiography, spectral domain optical coherence tomography and electroretinogram analyses were performed. Their sister was also examined. All subjects were screened for mutations in the RS1 gene...
September 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28811844/lsd1-dual-function-in-mediating-epigenetic-corruption-of-the-vitamin-d-signaling-in-prostate-cancer
#20
Sebastiano Battaglia, Ellen Karasik, Bryan Gillard, Jennifer Williams, Trisha Winchester, Michael T Moser, Dominic J Smiraglia, Barbara A Foster
BACKGROUND: Lysine-specific demethylase 1A (LSD1) is a key regulator of the androgen (AR) and estrogen receptors (ER), and LSD1 levels correlate with tumor aggressiveness. Here, we demonstrate that LSD1 regulates vitamin D receptor (VDR) activity and is a mediator of 1,25(OH)2-D3 (vitamin D) action in prostate cancer (PCa). METHODS: Athymic nude mice were xenografted with CWR22 cells and monitored weekly after testosterone pellet removal. Expression of LSD1 and VDR (IHC) were correlated with tumor growth using log-rank test...
2017: Clinical Epigenetics
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