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https://www.readbyqxmd.com/read/29053994/dietary-resveratrol-confers-apoptotic-resistance-to-oxidative-stress-in-myoblasts
#1
Satoshi Haramizu, Shinichi Asano, David C Butler, David A Stanton, Ameena Hajira, Junaith S Mohamed, Stephen E Alway
High levels of reactive oxygen species (ROS) contribute to muscle cell death in aging and disuse. We have previously found that resveratrol can reduce oxidative stress in response to aging and hindlimb unloading in rodents in vivo, but it was not known if resveratrol would protect muscle stem cells during repair or regeneration when oxidative stress is high. To test the protective role of resveratrol on muscle stem cells directly, we treated the C2C12 mouse myoblast cell line with moderate (100 μM) or very high (1 mM) levels of H2O2 in the presence or absence of resveratrol...
August 24, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29053668/laboratory-protocol-for-genetic-gut-content-analyses-of-aquatic-macroinvertebrates-using-group-specific-rdna-primers
#2
Meike Koester, René Gergs
Analyzing food webs is essential for a better understanding of ecosystems. For example, food web interactions can undergo severe changes caused by the invasion of non-indigenous species. However, an exact identification of field predator-prey interactions is difficult in many cases. These analyses are often based on a visual evaluation of gut content or the analysis of stable isotope ratios (δ(15)N and δ(13)C). Such methods require comprehensive knowledge about, respectively, morphologic diversity or isotopic signature from individual prey organisms, leading to obstacles in the exact identification of prey organisms...
October 5, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29053503/lenalidomide-associated-thyroid-related-eyelid-retraction
#3
Geraldine R Slean, Rona Z Silkiss
Several antineoplastic treatments have been responsible for thyroid dysfunction and thyroid eye disease. Min, Vaidya, and Becker (2011) reported a case of euthyroid Graves orbitopathy after treatment with ipilimumab with the patient displaying proptosis and myositis in the setting of normal thyroid function tests and elevated thyroid antibodies. The authors report a case of a 76-year-old woman who developed right upper lid retraction and proptosis after 2.5 years of treatment with lenalidomide for multiple myeloma...
October 19, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29052967/the-island-cotton-nbs-lrr-gene-gbana1-confers-resistance-to-the-non-race-1-verticillium-dahliae-isolate-vd991
#4
Nan-Yang Li, Xue-Feng Ma, Dylan P G Short, Ting-Gang Li, Lei Zhou, Yue-Jing Gui, Zhi-Qiang Kong, Dan-Dan Zhang, Wen-Qi Zhang, Jun-Jiao Li, Krishna V Subbarao, Jie-Yin Chen, Xiao-Feng Dai
Wilt caused by Verticillium dahliae significantly reduces cotton yields, as host resistance in commercially cultivated Gossypium species is lacking. Understanding the molecular bases of disease resistance in non-commercial Gossypium species could galvanize the development of Verticillium wilt resistance in the cultivated species. Nucleotide binding site-leucine-rich repeat (NBS-LRR) proteins play a central role in plant defense against pathogens. In this study, we focused on the relationship between a locus enriched with eight NBS-LRR genes and Verticillium wilt resistance in G...
October 20, 2017: Molecular Plant Pathology
https://www.readbyqxmd.com/read/29052625/a-parts-per-billion-measurement-of-the-antiproton-magnetic-moment
#5
C Smorra, S Sellner, M J Borchert, J A Harrington, T Higuchi, H Nagahama, T Tanaka, A Mooser, G Schneider, M Bohman, K Blaum, Y Matsuda, C Ospelkaus, W Quint, J Walz, Y Yamazaki, S Ulmer
Precise comparisons of the fundamental properties of matter-antimatter conjugates provide sensitive tests of charge-parity-time (CPT) invariance, which is an important symmetry that rests on basic assumptions of the standard model of particle physics. Experiments on mesons, leptons and baryons have compared different properties of matter-antimatter conjugates with fractional uncertainties at the parts-per-billion level or better. One specific quantity, however, has so far only been known to a fractional uncertainty at the parts-per-million level: the magnetic moment of the antiproton, ...
October 18, 2017: Nature
https://www.readbyqxmd.com/read/29052210/a-method-for-testing-random-spatial-models-on-nuclear-object-distributions
#6
Javier Arpòn, Valérie Gaudin, Philippe Andrey
The cell nucleus is a structurally complex and dynamic organelle ensuring key biological functions. Complex relationships between nuclear structure and functions require a better understanding of the three-dimensional organization of the genome and of the subnuclear compartments. Quantitative image analysis coupled with spatial statistics and modeling is a relevant approach to address these questions. In this chapter, we describe a step-by-step procedure to process images and to test a spatial random model for the distribution of nuclear objects using chromocenters as an example...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29048660/canonical-and-non-canonical-wnt-signaling-in-cancer-stem-cells-and-their-niches-cellular-heterogeneity-omics-reprogramming-targeted-therapy-and-tumor-plasticity-review
#7
Masaru Katoh
Cancer stem cells (CSCs), which have the potential for self-renewal, differentiation and de-differentiation, undergo epigenetic, epithelial-mesenchymal, immunological and metabolic reprogramming to adapt to the tumor microenvironment and survive host defense or therapeutic insults. Intra-tumor heterogeneity and cancer-cell plasticity give rise to therapeutic resistance and recurrence through clonal replacement and reactivation of dormant CSCs, respectively. WNT signaling cascades cross-talk with the FGF, Notch, Hedgehog and TGFβ/BMP signaling cascades and regulate expression of functional CSC markers, such as CD44, CD133 (PROM1), EPCAM and LGR5 (GPR49)...
September 19, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29046507/subretinal-implantation-of-okayama-university-type-retinal-prosthesis-ourep-tm-in-canine-eyes-by-vitrectomy
#8
Toshihiko Matsuo, Tetsuya Uchida, Makoto Nitta, Koichiro Yamashita, Shigiko Takei, Daisuke Ido, Mamoru Tanaka, Masao Oguchi, Toshinori Furukawa
Okayama University-type retinal prosthesis (OUReP(TM)) is a photoelectric dye-coupled polyethylene film which generates electric potential in response to light and stimulates nearby neurons. This study aims to test surgical feasibility of subretinal implantation and functional durability of dye-coupled films in the subretinal space. The dye-coupled films were implanted subretinally by 25-gauge vitrectomy in the right eye of 11 normal beagle dogs: 2 dogs served for film removal after 5-month film implantation, 3 dogs for film removal after 3-month film implantation, 3 dogs for 3-month film implantation and pathological examination, and 3 dogs for sham surgery...
October 18, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29044928/a-rare-variant-rs933717-at-fbxo31-map1lc3b-in-chinese-is-associated-with-systemic-lupus-erythematosus
#9
Yuan-Yuan Qi, Xu-Jie Zhou, Swapan K Nath, Celi Sun, Yan-Na Wang, Ping Hou, Rong Mu, Chun Li, Jian-Ping Guo, Zhan-Guo Li, Geng Wang, Hu-Ji Xu, Yan-Jie Hao, Zhuo-Li Zhang, Wei-Hua Yue, Huo-Ru Zhang, Ming-Hui Zhao, Hong Zhang
OBJECTIVE: Recent evidence from genetic, cell biology and model animal studies have suggested a pivotal role of autophagy in mediating systemic lupus erythematosus (SLE). However, the genetic basis has not yet been thoroughly examined. The aim of the present study was therefore to identify additional susceptibility variants in autophagy-related genes, and their functional significance. METHODS: First, we performed a gene family-based genetic association analysis in patients with SLE using ImmunoChip, and selected the top-associated polymorphisms for replication in additional cohorts...
October 17, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29043959/purified-citritin-in-combination-with-vancomycin-inhibits-vre-in-vitro-and-in-vivo
#10
Kléber de Sousa Oliveira, Paulo Roberto Martins Queiroz, Isabel Cristina Marques Fensterseifer, Ludovico Migliolo, Aline Lima Oliveira, Octávio Luiz Franco
Gram-positive pathogens such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE) have been frequently associated with bacterial resistance mechanisms. These mechanisms, in turn, restrict a range of therapeutic opportunities for the treatment of infections caused by these micro-organisms. Faced with this problem, the present study aims to isolate and characterize molecules with antimicrobial activity derived from the fungus Penicillium citrinum isolated from Cerrado soil...
October 18, 2017: Microbiology
https://www.readbyqxmd.com/read/29043598/anti-human-immunodeficiency-virus-1-activities-of-pratensein-and-pratensein-glycoside-from-alhaji-maurorum-and-its-parasite-cuscuta-kotchiana
#11
Mandana Behbahani
OBJECTIVE: To test the anti-human immunodeficiency virus (HIV) activity of pure compounds isolated from aerial part extracts of Alhaji maurorum and its parasite Cuscuta kotchiana. METHODS: The anti-HIV-1 and anti-HIV-2 activities of these extracts were performed by use of quantitative polymerase chain reaction assay and high pure viral nucleic acid kit. The most active fractions against HIV-1 were detected by nuclear magnetic resonance as pratensein and pratensein glycoside respectively in A...
October 18, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29043143/focal-segmental-glomerulosclerosis-associated-with-mitochondrial-disease
#12
Kenneth Lim, David Steele, Andrew Fenves, Ravi Thadhani, Eliot Heher, Amel Karaa
Primary mitochondrial diseases (MD) are complex, heterogeneous inherited diseases caused by mutations in either the mitochondrial or nuclear DNA. Glomerular diseases in MD have been reported with tRNA mutation m.3243A>G causing a syndrome of mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS). We describe here a case of focal segmental glomerulosclerosis (FSGS) associated with a new tRNA mutation site. A 34-year-old man with a history of living related kidney transplantation, diabetes, hearing loss, and developmental delay presented to the outpatient clinic with complaints of new behavioral difficulties, worsening symptoms, and brain involvement on imaging...
2017: Clin Nephrol Case Stud
https://www.readbyqxmd.com/read/29043112/tumor-infiltrating-cd8-lymphocytes-predict-different-clinical-outcomes-in-organ-and-non-organ-confined-urothelial-carcinoma-of-the-bladder-following-radical-cystectomy
#13
Shiqiang Zhang, Jun Wang, Xinyu Zhang, Fangjian Zhou
Tumor-infiltrating lymphocytes (TILs) are associated with better clinical outcomes in many tumors. TILs represent a cell-mediated immune response against the carcinoma. CD8+ TILs are a crucial component of cell-mediated immunity. The significance of CD8+ TILs has not been reported respectively in organ- and non-organ-confined urothelial carcinoma (UC) of the bladder. We explored the prognostic value of CD8+ TILs in the two groups. The presence of CD8+ TILs was assessed by immunohistochemical staining of whole tissue sections from 75 organ and 51 non-organ-confined disease patients with long-term follow-up, and its correlation with clinicopathological features and overall survival (OS) was determined...
2017: PeerJ
https://www.readbyqxmd.com/read/29043060/origins-of-the-greenland-shark-somniosus-microcephalus-impacts-of-ice-olation-and-introgression
#14
Ryan P Walter, Denis Roy, Nigel E Hussey, Björn Stelbrink, Kit M Kovacs, Christian Lydersen, Bailey C McMeans, Jörundur Svavarsson, Steven T Kessel, Sebastián Biton Porsmoguer, Sharon Wildes, Cindy A Tribuzio, Steven E Campana, Stephen D Petersen, R Dean Grubbs, Daniel D Heath, Kevin J Hedges, Aaron T Fisk
Herein, we use genetic data from 277 sleeper sharks to perform coalescent-based modeling to test the hypothesis of early Quaternary emergence of the Greenland shark (Somniosus microcephalus) from ancestral sleeper sharks in the Canadian Arctic-Subarctic region. Our results show that morphologically cryptic somniosids S. microcephalus and Somniosus pacificus can be genetically distinguished using combined mitochondrial and nuclear DNA markers. Our data confirm the presence of genetically admixed individuals in the Canadian Arctic and sub-Arctic, and temperate Eastern Atlantic regions, suggesting introgressive hybridization upon secondary contact following the initial species divergence...
October 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29043056/genotype-by-sequencing-identifies-natural-selection-as-a-driver-of-intraspecific-divergence-in-atlantic-populations-of-the-high-dispersal-marine-invertebrate-macoma-petalum
#15
Stacy L Metivier, Jin-Hong Kim, Jason A Addison
Mitochondrial DNA analyses indicate that the Bay of Fundy population of the intertidal tellinid bivalve Macoma petalum is genetically divergent from coastal populations in the Gulf of Maine and Nova Scotia. To further examine the evolutionary forces driving this genetic break, we performed double digest genotype by sequencing (GBS) to survey the nuclear genome for evidence of both neutral and selective processes shaping this pattern. The resulting reads were mapped to a partial transcriptome of its sister species, M...
October 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29040786/development-characterization-and-testing-of-a-simplified-bonner-sphere-system-for-rapid-neutron-field-characterization
#16
Olivier Van Hoey, Filip Vanhavere, Lise Verbraeken
Personal neutron dosimetry requires workplace specific correction factors from detailed neutron field characterization. A Bonner sphere system (BSS) with a 3He proportional counter and a 3 inch an a 9 inch sphere was developed at SCK·CEN for rapid neutron field characterization. The BSS energy and angular responses were simulated with MCNPX and validated by irradiations with a thermal neutron beam at the Belgian Reactor 1 (BR1) and 252Cf and Am-Be sources at the SCK·CEN Laboratory for Nuclear Calibration (LNK)...
October 13, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29040769/effect-of-the-duration-of-meteorological-data-collection-on-the-prospective-assessment-of-long-term-atmospheric-dispersion-factors
#17
Yoomi Choi, Eun-Hee Kim
Assessing the environmental dispersion of radioactive effluents from a nuclear facility under normal operation is a prerequisite in applying for the construction permit and operation license of the facility. In Korea, the Nuclear Safety and Security Commission requires at least 1- and 2-year periods of site-specific meteorological data to assess the atmospheric dispersion of the effluents from a nuclear reactor facility for a construction permit and operating license, respectively. In this study, we investigated if an extended period of meteorological data would be certainly preferable for the prospective assessment of dispersion of the atmospheric effluents under current data handling approaches...
October 10, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29038898/molecular-and-immunological-characterisation-of-tropomyosin-from-anisakis-pegreffii
#18
Abdouslam Asnoussi, Ibukun E Aibinu, Robin B Gasser, Andreas L Lopata, Peter M Smooker
Tropomyosin (TM) is a major allergen in shellfish, known to cross-react with mite, cockroach and/or some roundworm (nematode) TM. In this study, we aimed to express and purify TM from the parasitic nematode Anisakis pegreffii and also to characterise its cross-reactivity with TM from shellfish. A. pegreffii was isolated from the flathead tiger fish (Neoplatycephalus richardsoni) and characterised using single-strand conformation polymorphism (SSCP)-based sequencing of the first and second internal transcribed spacers (ITS-1 and ITS-2) of nuclear ribosomal DNA...
October 16, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29038778/ophthalmological-abnormalities-in-wild-european-hedgehogs-erinaceus-europaeus-a-survey-of-300-animals
#19
David Williams, Nina Adeyeye, Erni Visser
In this study we aimed to examine wild European hedgehogs (Erinaceus europaeus) in rescue centres and to determine ocular abnormalities in this animal population. Three hundred animals varying in age from 2 months to 5 years were examined, 147 being male and 153 female. All animals were evaluated with direct and indirect ophthalmoscopy and slit lamp biomicroscopy in animals where lesions were detected. Tonometry using the Tonovet rebound tonometer was undertaken in selected animals as was assessment of tear production using the Schirmer I tear test...
2017: Open veterinary journal
https://www.readbyqxmd.com/read/29037905/the-inter-observer-reading-variability-in-anti-nuclear-antibodies-indirect-ana-immunofluorescence-test-a-multicenter-evaluation-and-a-review-of-the-literature
#20
REVIEW
A Rigon, M Infantino, M Merone, G Iannello, A Tincani, I Cavazzana, N Caraballese, A Radice, M Manfredi, P Soda, A Afeltra
Recently there has been an increase demand for computer-aided diagnosis (CAD) tools to sup- port clinicians in the field of Indirect ImmunoFluorescence (IIF), as the novel digital imaging reading approach can help to overcome the reader subjectivity. Nevertheless, a large multicenter evaluation of the inter-observer reading variability in this field is still missing. This work fills this gap as we evaluated 556 consecutive samples, for a total of 1679 images, collected in three laboratories with IIF expertise using HEp-2 cell substrate (MBL) at 1:80 screening dilution ac- cording to conventional procedures...
October 13, 2017: Autoimmunity Reviews
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