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https://www.readbyqxmd.com/read/28526430/combination-of-integrated-dynamic-shimming-and-readout-segmented-echo-planar-imaging-for-diffusion-weighted-mri-of-the-head-and-neck-region-at-3tesla
#1
Sven S Walter, Wei Liu, Alto Stemmer, Petros Martirosian, Konstantin Nikolaou, Mike Notohamiprodjo, Sergios Gatidis
PURPOSE: To evaluate the performance of combined integrated slice-by-slice shimming and readout-segmented EPI (irsEPI) for diffusion-weighted MR imaging (DWI) of the neck at 3Tesla. METHODS: This study was approved by the local ethics committee. An anthropometric phantom of the head/neck region incorporating compartments with different diffusivities was constructed. In vivo measurements were performed in 10 healthy volunteers. DWI of the phantom and volunteers was performed on a 3Tesla MR scanner using single shot EPI (sEPI), a prototype single shot EPI with integrated slice-by-slice shimming (iEPI), readout segmented EPI (rsEPI) and a prototype readout segmented EPI with integrated shimming irsEPI...
May 16, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28526428/extensively-drug-resistant-bacteria-which-ethical-issues
#2
P Vassal, P Berthelot, J P Chaussinand, S Jay, J P de Filippis, C Auboyer, F Renoux, D Bedoin
OBJECTIVE: The increased bacterial resistance to antibiotics has now become a public health concern. How can we preserve the well-being of patients presenting with infections caused by extensively drug-resistant bacteria (EDRBs) and that of their contacts without inducing any loss of chance of survival, all the while living together and controlling the spread of these EDRBs? METHOD: Terre d'éthique, a French territorial ethics committee, was asked to reflect on this topic by the infection control unit of a French University Hospital as it raises many ethical issues...
May 16, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/28523162/a-preliminary-exploration-of-the-intravoxel-incoherent-motion-applied-in-the-preoperative-evaluation-of-mediastinal-lymph-node-metastasis-of-lung-cancer
#3
Xin Ye, Shuo Chen, Yaru Tian, Bin You, Wenqian Zhang, Yan Zhao, Tao Jiang, Bin Hu, Hui Li
BACKGROUND: The aim of this study was to investigate the diagnostic value of the intravoxel incoherent motion (IVIM) for distinguishing non-metastatic from metastatic mediastinal lymph nodes in lung cancer. METHODS: IVIM-diffusion weighted imaging (DWI) exams were performed preoperatively on 66 patients with lung cancer from October 2015 to June 2016 in Beijing Chao-Yang Hospital, Capital Medical University. Fifty patients underwent enhanced chest computed tomography (CT) in our hospital, while the other 16 patients already had enhanced chest CT images when they were admitted...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28521373/paediatric-medicines-regulatory-and-scientific-issues
#4
Chrysa Daousani, Vangelis D Karalis
In the past, dosage regimens authorized for adults were extrapolated to children relying mainly on empirical dosage adjustments. However, children are not small adults, but a distinct and heterogeneous group in terms of physiology, disease occurrence, pharmacokinetics, pharmacodynamics and also psychological, cognitive, and behavioral aspects. Even though it would be helpful to know the physiological changes and the special drug treatment needs in children, this task could not be performed due to ethical reasons...
May 18, 2017: Drug Research
https://www.readbyqxmd.com/read/28516404/screening-for-diabetic-eye-disease-among-samoan-adults-a-pilot-study
#5
V Swetha E Jeganathan, Tim Langford, Lucilla Ah-Ching Sefo, Alex W Hewitt, Nitin Verma
INTRODUCTION: The purpose of this study was to determine the prevalence of diabetic retinopathy in Samoa by piloting a retinal photography screening programme. METHODS: We performed a cross-sectional study of patients with diabetes who presented to the Tupua Tamasese Meaole eye clinic in Apia, Samoa, between May 2011 and September 2011. Study approval was granted by the National Health Service Board of Samoa, the Monash University Human Research Ethics Committee, and the study adhered to the Tenets of the Declaration of Helsinki...
May 17, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28515933/evaluation-of-a-multiprofessional-nonsurgical-obesity-treatment-program-which-parameters-indicated-life-style-changes-and-weight-loss
#6
Pjanic, Roland Müller, Markus Laimer, Niels Hagenbuch, Kurt Laederach, Zeno Stanga
BACKGROUND: According to the current evidence, behavior modifications are an effective part of a non-surgical multiprofessional obesity treatment program (MOTP). The purpose of the present study was to report changes in weight as well in psychological variables during a one year MOTP. We aimed to identify the associations of emotional state and patients' emotion regulation skills with weight change. METHODS: Prospective interventional study. Data of participants attending the one year obesity treatment in either a group or individual structured MOTP were analyzed...
2017: Journal of Eating Disorders
https://www.readbyqxmd.com/read/28515198/post-authorisation-passive-enhanced-safety-surveillance-of-seasonal-influenza-vaccines-protocol-of-a-pilot-study-in-england
#7
Simon de Lusignan, Gaël Dos Santos, Ana Correa, François Haguinet, Ivelina Yonova, Florence Lair, Rachel Byford, Filipa Ferreira, Karen Stuttard, Tom Chan
AIM: To pilot enhanced safety surveillance of seasonal influenza vaccine meeting the European Medicines Agency (EMA) requirement to rapidly detect a significant increase in the frequency or severity of adverse events of interest (AEIs), which may indicate risk from the new season's vaccine. STUDY DESIGN: A prospective passive enhanced safety surveillance combining data collection from adverse drug reaction (ADR) cards with automated collection of pseudonymised routinely collected electronic health record (EHR) data...
May 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28515197/models-for-estimating-and-projecting-global-regional-and-national-prevalence-and-disease-burden-of-asthma-protocol-for-a-systematic-review
#8
Mohammad Romel Bhuia, Bright I Nwaru, Christopher J Weir, Aziz Sheikh
INTRODUCTION: Models that have so far been used to estimate and project the prevalence and disease burden of asthma are in most cases inadequately described and irreproducible. We aim systematically to describe and critique the existing models in relation to their strengths, limitations and reproducibility, and to determine the appropriate models for estimating and projecting the prevalence and disease burden of asthma. METHODS: We will search the following electronic databases to identify relevant literature published from 1980 to 2017: Medline, Embase, WHO Library and Information Services and Web of Science Core Collection...
May 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28515192/study-protocol-for-a-transversal-study-to-develop-a-screening-model-for-excessive-gambling-behaviours-on-a-representative-sample-of-users-of-french-authorised-gambling-websites
#9
Bastien Perrot, Jean-Benoit Hardouin, Jean-Michel Costes, Julie Caillon, Marie Grall-Bronnec, Gaëlle Challet-Bouju
INTRODUCTION: Since the legalisation of online gambling in France in 2010, gambling operators must implement responsible gambling measures to prevent excessive gambling practices. However, actually there is no screening procedure for identifying problematic gamblers. Although several studies have already been performed using several data sets from online gambling operators, the authors deplored several methodological and clinical limits that prevent scientifically validating the existence of problematic gambling behaviour...
May 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28513968/the-views-of-ethics-committee-members-and-medical-researchers-on-the-return-of-individual-research-results-and-incidental-findings-ownership-issues-and-benefit-sharing-in-biobanking-research-in-a-south-indian-city
#10
Manjulika Vaz, Mario Vaz, Srinivasan K
The return of individual research results and incidental findings from biobanking research is a much debated ethical issue globally but has extensive relevance in India where the burden of out of pocket health care expenses is high for the majority. The views of 21 ethics committee (EC) members and 22 researchers from Bengaluru, India, concerning the ethics of biobanking research were sought through in-depth interviews using an unfolding case vignette with probes. A shared view among most was that individual research results which are 'actionable' or have 'clinical significance' should be returned to the sample contributors through their treating physicians...
May 17, 2017: Developing World Bioethics
https://www.readbyqxmd.com/read/28511647/low-smoke-chulha-in-indian-slums-study-protocol-for-a-randomised-controlled-trial
#11
Megha Thakur, Esther A Boudewijns, Giridhara R Babu, Bjorn Winkens, Luc P de Witte, Jeroen Gruiskens, Preeti Sushama, Cristian T Ghergu, Onno C P van Schayck
BACKGROUND: Biomass fuel is used as a primary cooking source by more than half of the world's population, contributing to a high burden of disease. Although cleaner fuels are available, some households continue using solid fuels because of financial constraints and absence of infrastructure, especially in non-notified slums. The present study documents a randomised controlled study investigating the efficacy of improved cookstove on the personal exposure to air pollution and the respiratory health of women and children in an Indian slum...
May 16, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28508697/collagen-concentration-on-the-facial-skin-of-postmenopausal-women-after-topical-treatment-with-estradiol-and-genistein-a-randomized-double-blind-controlled-trial
#12
Lidia Aragão Silva, Adriana Aparecida Ferraz Carbonel, Andréa Regina Barbosa de Moraes, Ricardo S Simões, Gisela Rodrigues da Silva Sasso, Lívia Goes, Winnie Nunes, Manuel Jesus Simões, Marisa Teresinha Patriarca
OBJECTIVE: The objective of this study is to compare the effects of topical estrogen and genistein (a soy isoflavone) on the facial skin collagen of postmenopausal women not undergoing systemic hormonal therapy. METHODS: This is a prospective, double blind, randomized, controlled clinical trial. Volunteer women (N = 30) 45-55 year old from the Endocrine Gynecology sector of the Gynecology Department of the Federal University of São Paulo (UNIFESP). The Ethical Committee of the Federal University of São Paulo approved the study (report no...
May 16, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28507609/depression-and-alexithymia-on-weight-perception-in-patients-with-metabolic-syndrome-and-type-2-diabetes
#13
Maria Cristina de Oliveira Regina, Marcos Antonio Tambascia
BACKGROUND: Obesity's increasing follows decreased perception of weight status in obese persons, mainly female, undergoing age-related changes. OBJECTIVE: To study weight perception and psychological alterations associated to MS and T2DM. METHODS: 200 patients selected from Metabolic Syndrome Outpatient Clinic of University of Campinas. Instruments: Beck Depression and Beck Anxiety Inventories', Toronto Alexithymia Scale-26s, questionnaire and data from reports...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28506653/inhibition-of-denture-plaque-deposition-on-complete-dentures-by-2-methacryloyloxyethyl-phosphorylcholine-polymer-coating-a-clinical-study
#14
Kenji Ikeya, Fuminori Iwasa, Yuuki Inoue, Miya Fukunishi, Nana Takahashi, Kazuhiko Ishihara, Kazuyoshi Baba
STATEMENT OF PROBLEM: Denture plaque-associated infections are regarded as a source of serious dental and medical complications in the elderly population. Methods of managing this problem are needed. PURPOSE: The purpose of this clinical study was to evaluate the effects of treatment with a 2-methacryloyloxyethyl phosphorylcholine polymer, PMBPAz, on plaque deposition in complete dentures. MATERIAL AND METHODS: The study protocol was approved by the Ethics Committee of Showa University (#2013-013)...
May 12, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28506267/a-qualitative-study-on-acceptable-levels-of-risk-for-pregnant-women-in-clinical-research
#15
Indira S E van der Zande, Rieke van der Graaf, Martijn A Oudijk, Johannes J M van Delden
BACKGROUND: There is ambiguity with regard to what counts as an acceptable level of risk in clinical research in pregnant women and there is no input from stakeholders relative to such research risks. The aim of our paper was to explore what stakeholders who are actively involved in the conduct of clinical research in pregnant women deem an acceptable level of risk for pregnant women in clinical research. Accordingly, we used the APOSTEL VI study, a low-risk obstetrical randomised controlled trial, as a case-study...
May 15, 2017: BMC Medical Ethics
https://www.readbyqxmd.com/read/28501814/a-scoping-review-protocol-on-social-participation-of-indigenous-elders-intergenerational-solidarity-and-their-influence-on-individual-and-community-wellness
#16
Chantal Viscogliosi, Hugo Asselin, Suzy Basile, Yves Couturier, Marie-Josée Drolet, Dominique Gagnon, Jill Torrie, Mélanie Levasseur
INTRODUCTION: Indigenous elders have traditionally played an important role in maintaining social cohesion within their communities. Today, part of this role has been taken over by government social and healthcare services, but they are having limited success in addressing social challenges. Increasing elders' social participation and intergenerational solidarity might foster community development and benefit young people, families, communities and the elders themselves. However, knowledge of the contribution of elders' social participation and intergenerational solidarity to wellness is scattered and needs to be synthesised...
May 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/28500089/an-exploration-of-patients-experiences-of-participation-in-a-randomised-controlled-trial-of-the-manchester-acute-coronary-syndromes-macs-decision-rule
#17
Patricia van den Berg, Sarah Kendal, Helen V Alderson, Richard Body
BACKGROUND: As an important part of a pilot study to determine the feasibility of a large randomised controlled trial (RCT) comparing use of the Manchester Acute Coronary Syndromes (MACS) decision rule with standard care, we aimed to explore patient attitudes and potential barriers to participation in a trial of this nature. METHODS: We conducted a qualitative study nested within a pilot RCT comparing use of the MACS rule (which could enable some patients with chest pain to be discharged earlier) with standard care...
May 12, 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28500087/feasibility-of-the-manchester-acute-coronary-syndromes-macs-decision-rule-to-safely-reduce-unnecessary-hospital-admissions-a-pilot-randomised-controlled-trial
#18
Richard Body, Charles Boachie, Alex McConnachie, Simon Carley, Patricia Van Den Berg, Fiona E Lecky
BACKGROUND: Observational studies suggest that the Manchester Acute Coronary Syndromes (MACS) decision rule can effectively 'rule out' and 'rule in' acute coronary syndromes (ACS) following a single blood test. In a pilot randomised controlled trial, we aimed to determine whether a large trial is feasible. METHODS: Patients presenting to two EDs with suspected cardiac chest pain were randomised to receive care guided by the MACS decision rule (intervention group) or standard care (controls)...
May 12, 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28499753/emotional-intelligence-and-stress-management-in-nursing-professionals-in-a-hospital-emergency-department
#19
Tatiana Nespereira-Campuzano, Miriam Vázquez-Campo
OBJECTIVE: To determine stress levels and to identify if there is a relationship between emotional intelligence and work stress in nurses and healthcare assistants of the Emergency Department. METHOD: Observational, descriptive and cross-sectional study with a quantitative approach. The population were nurses and healthcare assistants of the Emergency Department of the University Hospital of Ourense. The data were collected between January and May 2016. The tool used was a validated, anonymous, and self-administered questionnaire that included the Trait Meta-Mood Scale and Moreno's Brief Burnout Questionnaire...
May 9, 2017: Enfermería Clínica
https://www.readbyqxmd.com/read/28499065/not-sick-enough-experiences-of-carers-of-people-with-mental-illness-negotiating-care-for-their-relatives-with-mental-health-services
#20
Michael Olasoji, Phil Maude, Kay McCauley
AIM: The literature reporting experiences of relatives of people with mental illness regarding their interactions with mental health services identifies many commonalities. However, the actual experience of carers engaging the services and understanding health care systems remains a gap in the literature. The aim of this study was to explore the experiences of carers (of people with a severe mental illness) in a major area mental health service in Victoria Australia as they fulfil their caring role whilst negotiating support for their relative...
May 12, 2017: Journal of Psychiatric and Mental Health Nursing
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