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https://www.readbyqxmd.com/read/29148894/metabolic-profile-in-patients-with-mild-obstructive-sleep-apnea
#1
Luciana Oliveira E Silva, Thais M Guimarães, Gabriela P Luz, Glaury Coelho, Luciana Badke, Ildonete R Almeida, Aline Millani-Carneiro, Sergio Tufik, Lia Bittencourt, Sonia M Togeiro
BACKGROUND: Mild obstructive sleep apnea (OSA) is a highly prevalent disorder in adults. However, it is not clear whether mild OSA has significant metabolic complications. This study examined the prevalence of metabolic syndrome (MS) in patients with mild OSA compared to control group. METHODS: Adults (18-65 years of age) of both genders with a body mass index (BMI) ≤35 kg/m(2) were included. The mild OSA group comprised of patients with an apnea-hypopnea index (AHI) score of ≥5 but ≤15 events/hr of sleep, independent of other symptoms...
November 17, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29148065/improvement-in-low-upright-baroreflex-sensitivity-is-associated-with-positive-clinical-effect-of-orthostatic-training
#2
Peter Mitro, Miloš Simurda, Ervin Muller
AIM: To assess the clinical efficacy of orthostatic training (OT) and its effect on the autonomic activity. METHODS: OT was performed in 38 patients (13 males, age 36.4 ± 15.2 years). Baroreflex sensitivity (BRS), heart rate variability and quality of life (SF 36) was assessed before and after 6 months of OT. Patients with no recurrence of syncope and reduction of the presyncope number to one-third or less were classified as responders. RESULTS: Compliance to OT was low...
November 16, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29146590/camkii%C3%AE-mediates-the-effect-of-il-17-to-promote-ongoing-spontaneous-and-evoked-pain-in-multiple-sclerosis
#3
Xiaoyu Hu, Fang Huang, Zaijie Jim Wang
Pain is a common and severe symptom in multiple sclerosis (MS), a chronic inflammatory and demyelinating disease of the central nervous system. The neurobiological mechanism underlying MS pain is poorly understood. In this study, we investigated the role of Ca(2+)/calmodulin dependent kinase type IIα (CaMKIIα) in driving chronic pain in MS using a mouse experimental autoimmune encephalomyelitis (EAE) model. We found that spinal CaMKIIα activity was enhanced in EAE correlating with the development of ongoing spontaneous pain and evoked hypersensitivity to mechanical and thermal stimuli...
November 16, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29143590/exercise-therapy-in-multiple-sclerosis-and-its-effects-on-function-and-the-brain
#4
Ulrik Dalgas
Exercise therapy is a promising nonpharmacological therapy in people with multiple sclerosis (MS). Although exercise training may induce a transient worsening of symptoms in some MS patients, it is generally considered safe and does not increase the risk of relapses. Exercise training can lead to clinically relevant improvements in physical function, but should be considered an adjunct to specific task-based training. Exercise has also shown positive effects on the brain, including improvements in brain volume and cognition...
November 2017: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/29143581/multiple-sclerosis-symptoms-and-spasticity-management-new-data
#5
Guillermo Izquierdo
Spasticity, perceived by patients as muscle rigidity and spasms, is a common symptom in multiple sclerosis (MS). It is associated with functional impairment that can exacerbate other MS symptoms and reduce quality of life. Pharmacological treatment options are limited and frequently ineffective. Treatment adherence is a key issue to address in these patients. The efficacy and safety of 9-delta-tetrahydrocannabinol:cannabidiol (THC:CBD) oromucosal spray for treatment of MS spasticity were demonstrated in four Phase III trials...
November 2017: Neurodegenerative Disease Management
https://www.readbyqxmd.com/read/29141825/radiculopathy-in-neuromyelitis-optica-how-does-anti-aqp4-ab-involve-pns
#6
Seungyeon Kim, Joonghyun Park, Bum Sun Kwon, Jin-Woo Park, Ho Jun Lee, Jin-Ho Choi, Kiyeun Nam
BACKGROUND: Until recently, the peripheral nervous system (PNS) had been known to be spared in multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). However, some studies of late have reported PNS damage in demyelination diseases of the central nervous system (CNS) such as MS and NMOSD. Although multiple studies have reported characteristics reminiscent of peripheral neuropathy in MS, there have been limited reports in NMOSD. To investigate the incidence and pathology of peripheral neuropathy in NMOSD, we reviewed articles describing such cases including our own case...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29141824/inhibition-of-neurogenesis-in-a-case-of-marburg-variant-multiple-sclerosis
#7
Celia Oreja-Guevara, Ulises Gómez-Pinedo, Julia García-López, Rafael Sánchez-Sánchez, Roberto Valverde-Moyano, Alberto Rabano-Gutierrez, Jordi A Matías-Guiu, Ines González-Suárez, Jorge Matías-Guiu
INTRODUCTION: Neural stem cells (NSC) are located essentially in the subventricular zone (SVZ), subgranular zone (SGZ), and along the central canal of the spinal cord. These cells can proliferate in vitro and differentiate into neurons, oligodendrocytes, and astroglia, thus contributing to repair in multiple sclerosis (MS). We conducted a pathological study to analyse neurogenic response in a patient with Marburg variant MS. METHODS: We present the case of a 27-year-old immunocompetent patient with Marburg variant MS, a fulminant form of the disease...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29141805/treating-depression-in-multiple-sclerosis-with-antidepressants-a-brief-review-of-clinical-trials-and-exploration-of-clinical-symptoms-to-guide-treatment-decisions
#8
REVIEW
Nabeela Nathoo, Aaron Mackie
Depression is a common comorbidity in patients with multiple sclerosis (MS). Those with MS and concurrent depression have poorer quality of life and are also less likely to be compliant with disease-modifying treatment, which may ultimately affect their MS disease course. Treating depression in MS with pharmacological agents can improve not only depression, but may also impact the MS disease course. However, no guidelines exist around treating depression in MS. Few randomized-controlled trials using antidepressants in MS exist...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29141793/information-processing-deficits-as-a-driving-force-for-memory-impairment-in-ms-a-cross-sectional-study-of-memory-functions-and-mri-in-early-and-late-stage-ms
#9
Wolfgang Köhler, Martin Fischer, Peter Bublak, Jürgen H Faiss, Frank Hoffmann, Annett Kunkel, Michael Sailer, Matthias Schwab, Erhard Stadler, Uwe K Zettl, Iris-Katharina Penner
BACKGROUND: Memory impairment (MI) is a common symptom of MS. Previous studies were conflicting in respect to the possible existence of early MI and the role of hippocampal atrophy. The objective of this study was to investigate MI and structural MRI correlates in homogenous groups of early and late MS, controlling for a potential information-processing speed (IPS) deficit, and utilizing multiple memory test paradigms. METHODS: 152 individually matched subjects were recruited: early MS (EMS, N = 25, disease duration 1...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29136292/clinical-and-genetic-characteristics-of-pseudohypoparathyroidism-in-the-chinese-population
#10
Xueying Chu, Yan Zhu, Ou Wang, Min Nie, Tingting Quan, Yu Xue, Wenbo Wang, Yan Jiang, Mei Li, Weibo Xia, Xiaoping Xing
BACKGROUND: Pseudohypoparathyroidism (PHP) is caused by mutations and epimutations in the GNAS locus, and characterized by the possibility of resistance to multiple hormones and Albright's hereditary osteodystrophy. PHP can be classified into the forms 1A/C, sporadic 1B, and familial 1B. OBJECTIVES: To obtain an overall view of the clinical and genetic characteristics of the Chinese PHP patient population. METHODS: From 2000 to 2016, 120 patients were recruited and studied using Sanger sequencing, methylation-specific multiple ligation-dependent probe amplification (MS-MLPA), and combined bisulfiterestriction analysis (COBRA)...
November 14, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29132642/validity-of-arabic-version-of-the-two-question-quick-inventory-of-depression-qid-2-ar-screening-for-multiple-sclerosis-in-an-arab-environment-and-during-the-syrian-war
#11
A Kubitary, M A Alsaleh
PURPOSE: This study aimed to validate the Arabic version of the two-question Quick Inventory of Depression (QID-2-Ar) in multiple sclerosis (MS) patients living in Syria during the war. METHODS: A total of 100 Syrian MS patients, aged 18-60 years, were recruited at Damascus Hospital and Ibn Al-Nafees Hospital to validate the QID-2-Ar, including analyses of its screening test parameters and its construct validity. RESULTS: The QID-2-Ar screening parameters for depression tested very positively, and its construct validity was also favorable (P<0...
November 10, 2017: Revue Neurologique
https://www.readbyqxmd.com/read/29131010/blockade-of-experimental-multiple-sclerosis-by-inhibition-of-the-acid-sphingomyelinase-ceramide-system
#12
Katrin Anne Becker, Ramona Halmer, Laura Davies, Brian D Henry, Regan Ziobro-Henry, Yann Decker, Yang Liu, Erich Gulbins, Klaus Fassbender, Silke Walter
BACKGROUND: Multiple sclerosis (MS) is a severe and common autoimmune disorder of the central nervous system. Despite the availability of several novel treatment options, the disease is still poorly controlled, since the pathophysiological mechanisms are not fully understood. METHODS: We tested the role of the acid sphingomyelinase/ceramide system in a model of MS, i.e. experimental autoimmune encephalomyelitis (EAE). Mice were immunized with myelin-oligodendrocyte glycoprotein and the development of the disease was analyzed by histology, immunological tests and clinical assessment in wildtype and acid sphingomyelinase (Asm)-deficient mice...
November 6, 2017: Neuro-Signals
https://www.readbyqxmd.com/read/29128863/persistent-long-term-structural-functional-and-metabolic-changes-after-stress-induced-takotsubo-cardiomyopathy
#13
Caroline Scally, Amelia Rudd, Alice Mezincescu, Heather Wilson, Janaki Srinivasan, Graham Horgan, Paul Broadhurst, David E Newby, Anke Henning, Dana K Dawson
BACKGROUND : Takotsubo cardiomyopathy is an increasingly recognized acute heart failure syndrome precipitated by intense emotional stress. Although there is an apparent rapid and spontaneous recovery of left ventricular ejection fraction, the long-term clinical and functional consequences of takotsubo cardiomyopathy are ill-defined. METHODS : In an observational case-control study, we recruited 37 patients with prior (>12-month) takotsubo cardiomyopathy, and 37 age-, sex-, and comorbidity-matched control subjects...
November 11, 2017: Circulation
https://www.readbyqxmd.com/read/29128151/is-the-choosing-wisely-%C3%A2-campaign-model-applicable-to-the-management-of-multiple-sclerosis-in-france-a-gresep-pilot-study
#14
B Trumbic, H Zéphir, J-C Ouallet, E Le Page, D Laplaud, C Bensa, J de Sèze
BACKGROUND: Launched in the US in 2012, Choosing Wisely(®) is a campaign promoted by the American Board of Internal Medicine (ABIM) Foundation with the goal of improving healthcare effectiveness by avoiding wasteful or unnecessary medical tests, treatments and procedures. It uses concise recommendations produced by national medical societies to start discussions between physicians and patients on the relevance of these services as part of a shared decision-making process. The Multiple Sclerosis Focus Group (Groupe de Reflexion Autour de la Sclérose en Plaques; GRESEP) undertook a pilot study to assess the relevance and feasibility of this approach in the management of multiple sclerosis (MS) in France...
November 8, 2017: Revue Neurologique
https://www.readbyqxmd.com/read/29125969/psychiatric-comorbidities-and-suicidality-among-patients-with-neuromyelitis-optica-spectrum-disorders-in-argentina
#15
V C Fernández, N Alonso, L Melamud, A M Villa
BACKGROUND: Neuromyelitis optica is a relapsing inflammatory, secondarily demyelinating astrocytopathy that most commonly affects the optic nerves and the spinal cord. OBJECTIVE: This study aimed to evaluate the psychopathological profile, presence of current depression, and suicidality in patients with neuromyelitis optica spectrum disorders (NMOSD) in an Argentinean cohort, and compare these parameters to those in patients with multiple sclerosis (MS) and in healthy controls (HCs)...
November 7, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29125968/the-prevalence-of-anxiety-and-associated-factors-in-persons-with-multiple-sclerosis
#16
Tram Pham, Nathalie Jetté, Andrew G M Bulloch, Jodie M Burton, Samuel Wiebe, Scott B Patten
BACKGROUND: The prevalence of anxiety and its association with sociodemographic and clinical factors is not well characterized in those with multiple sclerosis (MS). We aimed to estimate the prevalence and examine associated factors of anxiety in persons with MS. METHODS: A cross-sectional analysis was conducted utilizing data from 244 participants from the Neurological Disease and Depression study. Anxiety was assessed using the Hospital Anxiety and Depression Scale (HADS)...
November 7, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29119933/pharmacological-and-non-pharmacological-therapies-of-cognitive-impairment-in-multiple-sclerosis
#17
Elzbieta Miller, Agnieszka Morel, Justyna Redlicka, Igor Miller, Joanna Saluk
Cognitive impairment is one of the most important clinical features of neurodegenerative disorders including multiple sclerosis (MS). Conducted research shows that up to 65 percent of MS patients have cognitive deficits such as episodic memory, sustained attention, reduced verbal fluency; however, the cognitive MS domain is information processing speed. It is the first syndrome of cognitive dysfunction and the most widely affected in MS. Occasionally these impairments occur even before the appearance of physical symptoms...
November 9, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/29115915/neuromodulation-in-multiple-sclerosis
#18
Hesham Abboud, Eddie Hill, Junaid Siddiqui, Alessandro Serra, Benjamin Walter
Neuromodulation, or the utilization of advanced technology for targeted electrical or chemical neuronal stimulation or inhibition, has been expanding in several neurological subspecialties. In the past decades, immune-modulating therapy has been the main focus of multiple sclerosis (MS) research with little attention to neuromodulation. However, with the recent advances in disease-modifying therapies, it is time to shift the focus of MS research to neuromodulation and restoration of function as with other neurological subspecialties...
November 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29113955/treatment-of-fatigue-with-methylphenidate-modafinil-and-amantadine-in-multiple-sclerosis-triumphant-ms-study-design-for-a-pragmatic-randomized-double-blind-crossover-clinical-trial
#19
Bardia Nourbakhsh, Nisha Revirajan, Emmanuelle Waubant
BACKGROUND: Fatigue is the most common symptom of multiple sclerosis (MS). Amantadine, modafinil and amphetamine-like stimulants are commonly used in clinical practice for treatment of fatigue; however, the evidence supporting their effectiveness is sparse and conflicting. OBJECTIVE: To describe the design of a trial study funded by Patient-Centered Outcome Research Institute (PCORI) that will compare the efficacy of commonly used fatigue medications in patients with MS...
November 4, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29111011/improvement-of-quality-of-life-and-its-relationship-with-neuropsychiatric-outcomes-in-patients-with-multiple-sclerosis-starting-treatment-with-natalizumab-a-3-year-follow-up-multicentric-study
#20
Vincent Planche, Xavier Moisset, Remy Morello, Emilie Dumont, Marion Gibelin, Julie Charré-Morin, Aurore Saubusse, Audrey Mondou, Françoise Reuter, Gilles Defer, Jean Pelletier, Bruno Brochet, Pierre Clavelou
BACKGROUND: Health-related quality of life (HRQoL) is impaired in multiple sclerosis (MS) but can be improved by disease-modifying therapies such as natalizumab. However, the predictive factors and neuropsychiatric correlates of HRQoL improvement are unknown. METHODS: In this study, 48 patients with relapsing-remitting MS were included in a 3-year open-label, single group, multicenter, clinical trial (NCT01392872). HRQoL was measured by the disease-specific MusiQoL questionnaire, together with physical disability, cognition, fatigue, anxiety and depression scores at baseline, 6months, 12months, 18months and 36months after starting natalizumab therapy...
November 15, 2017: Journal of the Neurological Sciences
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