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https://www.readbyqxmd.com/read/28428069/assessment-of-non-derivatized-%C3%AE-n-methylamino-l-alanine-bmaa-neurotoxin-in-free-form-in-urine-of-patients-with-nonspecific-neurological-symptoms
#1
L Bláhová, J Kohoutek, E Kadlecová, L Kozáková, L Bláha
The beta-N-methylamino-L-alanine (BMAA) is a non-proteinogenic amino acid discussed to be produced by cyanobacteria forming harmful blooms. Since BMAA is suspected etiological agent in neurodegenerative diseases, there is a need to study and validate whether and in what concentrations can BMAA be present in human tissues. The aim of the present study was to validate analytical and extraction procedures for quantification of non-derivatized BMAA in the urine using liquid chromatography and commercial ELISA Kit...
April 17, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28427707/incidence-of-multiple-sclerosis-in-the-republic-of-ireland-a-prospective-population-based-study
#2
K O'Connell, N Tubridy, M Hutchinson, C McGuigan
BACKGROUND: Multiple sclerosis (MS) incidence and prevalence is increasing worldwide, with a disproportionally higher rate in women. Recent studies have questioned the presence of a latitudinal gradient in Europe. Ireland is a high prevalence country for MS with a previously reported North-South gradient making it ideal to further explore this concept. OBJECTIVES: In this study we prospectively determined the incidence rate of newly diagnosed MS in Ireland over a 12-month period and demonstrated the presence of a North-South gradient...
April 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28427691/spastic-paretic-hemifacial-contracture-as-a-presenting-feature-of-multiple-sclerosis
#3
Georgios Koutsis, Marianthi Breza, Maria-Eleftheria Evangelopoulos, Maria Anagnostouli, Elisavet Andreadou, Georgios Karagiorgis, Panagiotis Kokotis, Costas Kilidireas, Nikolaos Karandreas
BACKGROUND: Spastic paretic hemifacial contracture (SPHC) is characterized by sustained unilateral contraction of the facial muscles associated with mild ipsilateral facial paresis. Rarely described in the context of multiple sclerosis (MS), it has never been reported as presenting symptom of MS. CASE REPORTS: Two patients developed SPHC within the context of a clinically isolated syndrome suggestive of MS. EMG revealed continuous resting activity of irregularly firing motor unit potentials, associated with impaired recruitment upon voluntary contraction...
April 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28425447/development-and-pre-clinical-evaluation-of-recombinant-human-myelin-basic-protein-nano-therapeutic-vaccine-in-experimental-autoimmune-encephalomyelitis-mice-animal-model
#4
Medhat A Al-Ghobashy, Aliaa N ElMeshad, Rania M Abdelsalam, Mohammed M Nooh, Muhammad Al-Shorbagy, Götz Laible
Recombinant human myelin basic protein (rhMBP) was previously produced in the milk of transgenic cows. Differences in molecular recognition of either hMBP or rhMBP by surface-immobilized anti-hMBP antibodies were demonstrated. This indicated differences in immunological response between rhMBP and hMBP. Here, the activity of free and controlled release rhMBP poly(ε-caprolactone) nanoparticles (NPs), as a therapeutic vaccine against multiple sclerosis (MS) was demonstrated in experimental autoimmune encephalomyelitis (EAE) animal model...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28424890/left-atrial-electromechanical-conduction-time-predicts-atrial-fibrillation-in-patients-with-mitral-stenosis-a-5-year-follow-up-speckle-tracking-echocardiography-study
#5
Ozkan Candan, Cetin Gecmen, Arzu Kalayci, Cem Dogan, Emrah Bayam, Mehmet Ozkan
Prolonged left atrial electromechanical conduction time is related with atrial electrical remodeling, and is predictive of the development of atrial fibrillation. The aim of our study was to examine whether left atrial electromechanical conduction time (EMT) and left atrial strain as measured by speckle tracking echocardiography (STE) are predictors for the development of atrial fibrillation (AF) in patients with mitral stenosis (MS) at 5-year follow-up. A total of 81 patients (61% females; mean age 38.1 ± 12...
April 19, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28422664/diaper-embedded-urinary-tract-infection-monitoring-sensor-module-powered-by-urine-activated-batteries
#6
Weeseong Seo, Wuyang Yu, Tianlin Tan, Babak Ziaie, Byunghoo Jung
Urinary tract infection (UTI) is one of the most common infections in humans. UTI is easily treatable using antibiotics if identified in early stage. However, without early identification and treatment, UTI can be a major source of serious complications in geriatric patients, in particular, those suffering from neurodegenerative diseases. Also, for infants who have difficulty in describing their symptoms, UTI may lead to serious development of the disease making early identification of UTI crucial. In this paper, we present a diaper-embedded, wireless, self-powered, and autonomous UTI monitoring sensor module that allows an early detection of UTI with minimal effort...
April 14, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28421377/vep-and-perg-in-patients-with-multiple-sclerosis-with-and-without-a-history-of-optic-neuritis
#7
M Janáky, Á Jánossy, G Horváth, G Benedek, G Braunitzer
PURPOSE: Visual electrophysiology is routinely used to detect the visual complications of multiple sclerosis, but the analysis mostly focuses on visual evoked potential (VEP) and especially the P100 component. Our goal was to analyze the components and waveform alterations of VEPs and pattern electroretinograms (PERGs) in patients with multiple sclerosis (MS) with good vision. METHODS: The main VEP and PERG components of 85 patients with MS were analyzed in two groups: 38 patients who had optic neuritis in their history (ON group) and 47 patients who had never had optic neuritis (MS group)...
April 18, 2017: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/28419819/path-to-illness-intrusiveness-what-symptoms-impact-the-life-of-people-living-with-multiple-sclerosis
#8
Vanessa Bouchard, Pierre Duquette, Nancy E Mayo
OBJECTIVE: To determine the direct and indirect effects of physical, emotional, and cognitive impairments on illness intrusiveness in people with MS. DESIGN: Secondary analysis of a cross sectional data set collected in 2008 to identify gender differences in people living with MS. SETTING: Three MS clinics in the Greater Montréal region, Canada. PARTICIPANTS: A random sample of 135 women and 48 men diagnosed with Multiple Sclerosis after 1995 recruited and evaluated in 2008...
April 15, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28418399/restoring-effects-of-oxytocin-on-the-attentional-preference-for-faces-in-autism
#9
M Kanat, I Spenthof, A Riedel, L T van Elst, M Heinrichs, G Domes
Reduced attentional preference for faces and symptoms of social anxiety are common in autism spectrum disorders (ASDs). The neuropeptide oxytocin triggers anxiolytic functions and enhances eye gaze, facial emotion recognition and neural correlates of face processing in ASD. Here we investigated whether a single dose of oxytocin increases attention to faces in ASD. As a secondary question, we explored the influence of social anxiety on these effects. We tested for oxytocin's effects on attention to neutral faces as compared to houses in a sample of 29 autistic individuals and 30 control participants using a dot-probe paradigm with two different presentation times (100 or 500 ms)...
April 18, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28416274/fatigue-in-multiple-sclerosis-insights-into-evaluation-and-management
#10
REVIEW
Samar S Ayache, Moussa A Chalah
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system, characterized by the accumulation of numerous neurological symptoms and signs throughout its course. Fatigue is one of the most distressing complaints that MS patients may experience over their lifetime. In spite of its high prevalence, the pathophysiology of MS fatigue is far from being fully elucidated and a constellation of mechanisms seems implicated in this setting. Several factors could contribute to its development and/or exacerbation, and this requires a careful workup in order to search for all possible underlying causes, such as sleep disturbances, endocrine dysfunction and mood disorders, to cite a few...
April 14, 2017: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/28415098/p569diastolic-dyssynchrony-is-associated-with-exercise-intolerance-in-hypertensive-patients-with-left-ventricular-hypertrophy
#11
I H Jung, H S Seo, M J Kim
Background: Left ventricular hypertrophy (LVH) is associated with intra-ventricular dyssynchrony at systolic phase during exercise in hypertensive patients. However, dypsnea on exertion is much more correlated with diastolic phase. We investigated whether LVH is associated with diastolic dyssynchrony during exercise in patients with hypertension. Methods: Ninety hypertensive patients with exertional dyspnea and 30 control individuals were enrolled. Exercise stress echocardiography was performed using a symptom limited, multistage supine bicycle test...
December 1, 2016: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28414161/metabolism-of-okadaic-acid-by-nadph-dependent-enzymes-present-in-human-or-rat-liver-s9-fractions-results-in-different-toxic-effects
#12
Franziska Kolrep, Kathleen Rein, Alfonso Lampen, Stefanie Hessel
The lipophilic marine biotoxin okadaic acid (OA) represents a natural contaminant produced by algae accumulating in seafood. Acute intoxications result in diarrhetic shellfish poisoning causing symptoms like nausea, vomiting and abdominal cramps. OA was preincubated with liver enzymes present in S9 fractions from humans, rats and rats pretreated with enzyme inducers in the presence or absence of the cofactor NADPH to investigate hepatic metabolism. Cytotoxicity was examined in HepG2 cells and metabolites of OA were determined by LC-MS/MS...
April 14, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28410279/ocular-motor-manifestations-of-multiple-sclerosis
#13
Elodie Nerrant, Caroline Tilikete
BACKGROUND: Multiple sclerosis (MS) is a demyelinating disease of the central nervous system leading to disability, especially in young patients. Acute or chronic lesions of MS within the brainstem and the cerebellum frequently result in ocular motor disorders. EVIDENCE ACQUISITION: This review encompasses the spectrum of ocular motor disorders in patients with MS emphasizing prevalence, examination findings, diagnostic features, functional consequences, classification of MS course, and management of these disturbances of ocular motility...
April 13, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28409663/prevalence-and-risk-factors-of-musculoskeletal-symptoms-among-dental-students-and-dental-practitioners-in-riyadh-city-saudi-arabia
#14
Zaina Al-Shehri, Mustafa Al Zoughool
This study assessed the nature, prevalence, and risk factors of musculoskeletal symptoms (MS) in dental clinics. A self-administered questionnaire was completed by 515 dental students and dentists about nature of work and prevalence and frequency of MS symptoms. Chi-square and logistic regression were used to determine the association of MS with a number of important variables. Pain in the lower back (64%) and neck (60%) were the most prevalent MS. Working in the dental colleges' clinics was associated with increased risk of MS (adjusted OR 2...
April 14, 2017: Archives of Environmental & Occupational Health
https://www.readbyqxmd.com/read/28408630/current-and-emerging-therapies-in-multiple-sclerosis-implications-for-the-radiologist-part-1-mechanisms-efficacy-and-safety
#15
REVIEW
C McNamara, G Sugrue, B Murray, P J MacMahon
Imaging for the diagnosis and follow-up of patients with suspected or confirmed multiple sclerosis is a common scenario for many general radiologists and subspecialty neuroradiologists. The field of MS therapeutics has rapidly evolved with multiple new agents now being used in routine clinical practice. To provide an informed opinion in discussions concerning newer MS agents, radiologists must have a working understanding of the strengths and limitations of the various novel therapies. The role of imaging in MS has advanced beyond monitoring and surveillance of disease activity to include treatment complications...
April 13, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28406663/neuropsychological-correlates-of-theory-of-mind-deficits-in-patients-with-multiple-sclerosis
#16
Simona Raimo, Luigi Trojano, Simona Pappacena, Raffaella Alaia, Daniele Spitaleri, Dario Grossi, Gabriella Santangelo
BACKGROUND: Theory of mind (ToM) is the ability to understand and interpret another person's beliefs, intentions (cognitive ToM) and emotions (affective ToM). OBJECTIVE: To explore affective and cognitive ToM and their neuropsychological correlates in patients affected by multiple sclerosis (MS). MATERIAL AND METHOD: Forty MS patients and 40 matched control individuals underwent tasks assessing cognitive (the ToM Pictures Sequencing Task and the Advanced Test of ToM) and affective ToM (the Reading the Mind in the Eyes Task and the Emotion Attribution Task), in both verbal and nonverbal modality, a comprehensive neuropsychological battery, and questionnaires for behavioral disorders...
April 13, 2017: Neuropsychology
https://www.readbyqxmd.com/read/28405955/cutaneous-adverse-reaction-during-lithium-treatment-a-case-report-and-updated-systematic-review-with-meta-analysis
#17
Martina Pinna, Mirko Manchia, Sergio Puddu, Giampaolo Minnai, Leonardo Tondo, Piergiorgio Salis
OBJECTIVES: To present a new case of adverse cutaneous reaction during lithium treatment and to update the systematic review and meta-analysis of the incidence of this adverse reaction. METHODS: We conducted a systematic search (performed in September 2016) for peer-reviewed articles in English indexed in Medline (2011-present). Meta-analytical estimates were obtained using the "Metafor" package. CASE PRESENTATION: Ms. H., a 31-year-old Caucasian woman with BD1, was admitted to the inpatient unit for a full-blown psychotic episode and treated with carbamazepine 400 mg q...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28401769/the-diagnostic-dilemma-of-multiple-sclerosis-presenting-with-isolated-cognitive-and-behavioral-disorders
#18
Maria Pia Amato
Cognitive and behavioral symptoms are common in multiple sclerosis (MS), even from the early stages of the disease, but they are considered to be rarely the inaugural and predominant manifestation of the disease, thus jeopardizing early and accurate diagnosis. This clinical commentary highlights a number of peculiar characteristics that should be taken into consideration in case of primary cognitive/neuropsychiatric dysfunction and white matter lesions of unclear origin, in order to prompt appropriate diagnostic workup...
April 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28401768/primary-progressive-multiple-sclerosis-presenting-with-severe-predominant-cognitive-impairment-and-psychiatric-symptoms-a-challenging-case
#19
Alberto Andrea Zambon, Giordano Cecchetti, Francesca Caso, Roberto Santangelo, Cristina Baldoli, Maria Grazia Natali Sora, Giancarlo Comi, Giuseppe Magnani, Vittorio Martinelli
Severe cognitive dysfunction is a frequent feature of multiple sclerosis (MS), normally associated with later stages of the disease in adult population. Nevertheless, progressive cognitive and neuropsychiatric disturbances might rarely be the presenting and predominant symptom. In order to better characterize this peculiar phenotype of MS, we report on the case of a 38-year-old man who referred to our hospital with the suspect of hereditary leukodystrophy after 5 years of behavioral and mood abnormalities, global cognitive dysfunction, clumsiness, and very mild pyramidal and cerebellar signs...
April 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28399842/deficits-of-perceived-spatial-separation-induced-prepulse-inhibition-in-patients-with-schizophrenia-relationships-to-symptoms-and-neurocognition
#20
Ning-Bo Yang, Qing Tian, Yu Fan, Qi-Jing Bo, Liang Zhang, Liang Li, Chuan-Yue Wang
BACKGROUND: Prepulse inhibition (PPI) and attention were impaired, which may cause psychotic symptoms and (or) hinder the cognitive functions in schizophrenia. However, due to the measurement methods of PPI, findings about the relationship between PPI and clinical symptoms, cognitive performances have been equivocal. METHODS: Seventy-five schizophrenia patients (SZ) and 50 healthy controls (HC) were assessed in a modified acoustic PPI paradigm, named perceived spatial separation-induced PPI (PSS-PPI), compared to perceived spatial co-location PPI (PSC-PPI) with inter-stimulus interval (ISI) of 120 ms...
April 11, 2017: BMC Psychiatry
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