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https://www.readbyqxmd.com/read/28222370/increased-postural-sway-in-persons-with-multiple-sclerosis-during-short-term-exposure-to-warm-ambient-temperatures
#1
Paula Y S Poh, Amy N Adams, Mu Huang, Dustin R Allen, Scott L Davis, Anna S Tseng, Craig G Crandall
BACKGROUND: Multiple sclerosis (MS) is a neurological disease marked by demyelination and axonal loss. Individuals with MS experience increases in clinical signs and symptoms during heat exposure. OBJECTIVE: To test the hypothesis that moderate heat exposure adversely affects postural sway in individuals with MS. METHODS: Ten individuals with relapsing-remitting MS (50±8y) and nine controls (47±10y) were examined under a Thermal and a Time Control trial...
February 8, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28221056/memory-support-strategies-and-bundles-a-pathway-to-improving-cognitive-therapy-for-depression
#2
Lu Dong, Jason Y Lee, Allison G Harvey
OBJECTIVE: Therapist use of memory support (MS) alongside treatment-as-usual, with the goal of enhancing patient recall of treatment contents, has been of recent interest as a novel pathway to improve treatment outcome. The memory support intervention (MSI) involves treatment providers' using 8 specific MS strategies to promote patient memory for treatment. The present study examines to what extent therapist use of MS strategies and bundles improves patient recall of treatment contents and treatment outcome...
March 2017: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/28216651/deficiency-of-the-g-protein-g%C3%AE-q-ameliorates-experimental-autoimmune-encephalomyelitis-with-impaired-dc-derived-il-6-production-and-th17-differentiation
#3
Weiming Lai, Yingying Cai, Jinfeng Zhou, Shuai Chen, Chaoyan Qin, Cuixia Yang, Junling Liu, Xin Xie, Changsheng Du
Many G protein-coupled receptors (GPCRs) are reported to be involved in the pathogenesis of multiple sclerosis (MS), and ~40% of all identified GPCRs rely on the Gαq/11 G protein family to stimulate inositol lipid signaling. However, the function of Gα subunits in MS pathogenesis is still unknown. In this study, we attempted to determine the role of Gαq in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), a well-known mouse model of MS. We discovered that compared with wild-type mice, Gαq-knockout mice exhibited less severe EAE symptoms, with lower clinical scores, reduced leukocyte infiltration and less extensive demyelination...
February 20, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28215060/efficacy-of-aquatic-therapy-for-multiple-sclerosis-a-systematic-review
#4
Iluminada Corvillo, Enrique Varela, Francisco Armijo, Antonio Alvarez-Badillo, Onica Armijo, Francisco Maraver
BACKGROUND: Multiple sclerosis (MS) is a chronic, inflammatory, progressive, disabling autoimmune disease affecting the central nervous system. Symptoms and signs of MS vary widely and patients may lose their ability to walk. To date the benefits of aquatic therapy often used for rehabilitation in MS patients have not been reviewed. OBJECTIVE: To systematically review the current state of aquatic treatment for persons with MS (hydrotherapy, aquatic therapy, aquatic exercises, spa therapy) and to evaluate the scientific evidence supporting the benefits of this therapeutic option...
February 17, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28213448/detection-and-monitoring-of-acute-myocarditis-applying-quantitative-cardiovascular-magnetic-resonance
#5
Florian von Knobelsdorff-Brenkenhoff, Johannes Schüler, Serkan Dogangüzel, Matthias A Dieringer, Andre Rudolph, Andreas Greiser, Peter Kellman, Jeanette Schulz-Menger
BACKGROUND: Cardiovascular magnetic resonance based on the Lake Louise Criteria is used to make the diagnosis of acute myocarditis. Novel quantitative parametric mapping techniques promise to overcome some of its limitations. We aimed to evaluate quantitative cardiovascular magnetic resonance to detect and monitor acute myocarditis. METHODS AND RESULTS: Eighteen patients with clinical diagnosis of acute myocarditis (25 years [23-38 years]; 78% males) were prospectively enrolled and repeatedly underwent cardiovascular magnetic resonance at 1...
February 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28211989/timothy-syndrome-1-genotype-without-syndactyly-and-major-extracardiac-manifestations
#6
Róbert Sepp, Lidia Hategan, Attila Bácsi, Judit Cseklye, László Környei, János Borbás, Márta Széll, Tamás Forster, István Nagy, Zoltán Hegedűs
Timothy syndrome 1 (TS1) is a rare genetic disorder characterized by multisystem abnormalities including QT prolongation, congenital heart defects, facial dysmorphism, episodic hypoglycemia, and neurological symptoms. A morphological hallmark of TS1 is syndactyly, present in all cases. TS1 is caused by the canonical p.Gly406Arg mutation in the alternatively spliced exon 8A in the CACNA1C gene, encoding for the main cardiac L-type calcium channel. A variant case of TS1 is reported. The proband had intermittent fetal bradycardia with heart rate of 72 bpm...
March 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28210020/p300-wave-changes-in-patients-with-parkinson-s-disease
#7
Kristina Tokic, Marina Titlic, Amira Beganovic-Petrovic, Enra Suljic, Rinaldo Romac, Slobodan Silic
INTRODUCTION: Parkinson's disease (PD) is chronic progressive neurodegenerative disease. In patients with Parkinson's disease among other symptoms occur cognitive dysfunctions, which can be shown by P300 wave changes. AIM: The aim of this study was to demonstrate that patients with Parkinson's disease have reduced amplitude and prolonged latency, longer than 300 ± 10 ms. MATERIAL AND METHODS: The study included 21 patient suffering from Parkinson's disease...
December 2016: Medical Archives
https://www.readbyqxmd.com/read/28182138/construct-validity-of-the-depression-and-somatic-symptoms-scale-evaluation-by-mokken-scale-analysis
#8
Ya-Hsin Chou, Chin-Pang Lee, Chia-Yih Liu, Ching-I Hung
OBJECTIVE: Previous studies of the Depression and Somatic Symptoms Scale (DSSS), a free scale, have been based on the classical test theory, and the construct validity and dimensionality of the DSSS are as yet uncertain. The aim of this study was to use Mokken scale analysis (MSA) to assess the dimensionality of the DSSS. METHODS: A sample of 214 psychiatric outpatients with mood and anxiety disorders were enrolled at a medical center in Taiwan (age: mean [SD] =38...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28179464/increased-default-mode-network-centrality-in-cognitively-impaired-multiple-sclerosis-patients
#9
Anand J C Eijlers, Kim A Meijer, Thomas M Wassenaar, Martijn D Steenwijk, Bernard M J Uitdehaag, Frederik Barkhof, Alle M Wink, Jeroen J G Geurts, Menno M Schoonheim
OBJECTIVE: To investigate how changes in functional network hierarchy determine cognitive impairment in multiple sclerosis (MS). METHODS: A cohort consisting of 332 patients with MS (age 48.1 ± 11.0 years, symptom duration 14.6 ± 8.4 years) and 96 healthy controls (HCs; age 45.9 ± 10.4 years) underwent structural MRI, fMRI, and extensive neuropsychological testing. Patients were divided into 3 groups: cognitively impaired (CI; n = 87), mildly cognitively impaired (MCI; n = 65), and cognitively preserved (CP; n = 180)...
February 8, 2017: Neurology
https://www.readbyqxmd.com/read/28178199/combined-use-of-delamanid-and-bedaquiline-to-treat-multidrug-resistant-and-extensively-drug-resistant-tuberculosis-a-systematic-review
#10
REVIEW
Giovanni Battista Migliori, Emanuele Pontali, Giovanni Sotgiu, Rosella Centis, Lia D'Ambrosio, Simon Tiberi, Marina Tadolini, Susanna Esposito
The new drugs delamanid and bedaquiline are increasingly being used to treat multidrug-resistant (MDR-) and extensively drug-resistant tuberculosis (XDR-TB). The World Health Organization, based on lack of evidence, recommends their use under specific conditions and not in combination. No systematic review has yet evaluated the efficacy, safety, and tolerability of delamanid and bedaquiline used in combination. A search of peer-reviewed, scientific evidence was carried out, aimed at evaluating the efficacy/effectiveness, safety, and tolerability of delamanid and bedaquiline-containing regimens in individuals with pulmonary/extrapulmonary disease, which were bacteriologically confirmed as M/XDR-TB...
February 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28178016/online-dietary-advice-for-the-symptomatic-management-of-multiple-sclerosis-a-scoping-review-protocol
#11
Jeffrey M Beckett, Marie-Louise Bird, Jane Pittaway, Kiran D K Ahuja
The objective of this scoping review is to identify, map and assess the range of dietary advice provided on websites for the symptomatic management of multiple sclerosis (MS), specifically in relation to the types of diets, relationship between specific food/diet/supplement and specific symptoms, citation of scientific literature to support claims and advice to consult a health professional (doctor/nutritionist/dietitian).Specifically the review question is: What dietary advice is available on websites for the symptomatic management of MS?...
February 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/28176596/-at-last-we-are-delivering-a-gold-standard-service
#12
Tamsin Newton Snow
Dermatology consultant nurse Karina Jackson leads a team of nurses treating patients with severe psoriasis, severe eczema and hidradenitis suppurativa, a chronic skin condition that causes abscesses and scarring. Although the physical symptoms of these conditions can be distressing, it is their psychological impact that Ms Jackson describes as heartbreaking.
February 8, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28176439/origanum-vulgare-essential-oil-affects-pathogens-causing-vaginal-infections
#13
Maja Karaman, Mirjana Bogavac, Bojan Radovanović, Jan Sudji, Kristina Tešanović, Ljiljana Janjušević
AIMS: This study aimed to investigate the application of Origanum vulgare L. essential oil (EO) as alternative antimicrobial agent against vaginal infections. METHODS AND RESULTS: Microdilution methods were applied for detection of minimal inhibitory (MIC) and minimal bactericidal/fungicidal MBC (MFC) concentration on 15 clinical strains originated from women with symptoms of vaginal infection. Optical density determination (OD) was used for detecton of Candida growth rate...
February 7, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28170436/the-effect-of-empiric-antimicrobial-treatment-duration-on-detection-of-bacterial-dna-in-sterile-surgical-specimens
#14
John Joseph Farrell, Huaping Wang, Rangarajan Sampath, Kristin S Lowery, Robert A Bonomo
Initial antimicrobial treatment of patients with deep seated or invasive infections is typically empiric. Usually, cultures of specimens obtained from the suspected source of infection are performed to identify pathogens and guide continued antimicrobial treatment. When patients present with signs and symptoms of infection, but sterile body fluid or tissue specimens cannot be obtained in a timely fashion, growth of bacterial pathogens in culture may be inhibited following initiation of empiric antibiotic treatment...
2017: PloS One
https://www.readbyqxmd.com/read/28169581/gray-matter-trophism-cognitive-impairment-and-depression-in-patients-with-multiple-sclerosis
#15
Emanuele Pravatà, Maria A Rocca, Paola Valsasina, Gianna C Riccitelli, Claudio Gobbi, Giancarlo Comi, Andrea Falini, Massimo Filippi
BACKGROUND: Cognitive impairment and depression frequently affects patients with multiple sclerosis (MS). However, the relationship between the occurrence of depression and cognitive impairment and the development of cortical atrophy has not been fully elucidated yet. OBJECTIVES: To investigate the association of cortical and deep gray matter (GM) volume with depression and cognitive impairment in MS. METHODS: Three-dimensional (3D) T1-weighted scans were obtained from 126 MS patients and 59 matched healthy controls...
February 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28165507/paeoniflorin-ameliorates-experimental-autoimmune-encephalomyelitis-via-inhibition-of-dendritic-cell-function-and-th17-cell-differentiation
#16
Han Zhang, Yuanyuan Qi, Yuanyang Yuan, Li Cai, Haiyan Xu, Lili Zhang, Bing Su, Hong Nie
Paeoniflorin (PF) is a monoterpene glycoside and exhibits multiple effects, including anti-inflammation and immunoregulation. To date, the effect of PF on multiple sclerosis (MS) has not been investigated. In this study, we investigated the effect of PF in experimental autoimmune encephalomyelitis (EAE), an animal model for MS. After administered with PF, the onset and clinical symptoms of EAE mice were significantly ameliorated, and the number of Th17 cells infiltrated in central nervous system (CNS) and spleen was also dramatically decreased...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28163856/29-year-old-man-with-multiple-sclerosis-and-schizophrenia-a-case-report
#17
Nahid Noorani, Fateme Hadi, Hamid Reza Ahmadkhaniha
Multiple sclerosis (MS) is the most common debilitating neurological disease that affects adults, whether young adults or middle-aged. Although, most attention is toward the neurological signs of the disease, the neuropsychiatric signs are not uncommon. This case report presents a 29 year old male with a record of obsessive-compulsive disorder (OCD) without psychotic disorder, which coincides with the diagnosis MS, has been stricken to auditory hallucinations and reference delusion. The patient received some antipsychotic drugs such as Haloperidol and Perphenazine irregularly, but any psychotic signs of the patient were never in control...
December 2016: Electronic Physician
https://www.readbyqxmd.com/read/28163834/does-heart-rate-variability-correlate-with-long-term-prognosis-in-myocardial-infarction-patients-treated-by-early-revascularization
#18
Leonida Compostella, Nenad Lakusic, Caterina Compostella, Li Van Stella Truong, Sabino Iliceto, Fabio Bellotto
AIM: To assess the prevalence of depressed heart rate variability (HRV) after an acute myocardial infarction (MI), and to evaluate its prognostic significance in the present era of immediate reperfusion. METHODS: Time-domain HRV (obtained from 24-h Holter recordings) was assessed in 326 patients (63.5 ± 12.1 years old; 80% males), two weeks after a complicated MI treated by early reperfusion: 208 ST-elevation myocardial infarction (STEMI) patients (in which reperfusion was successfully obtained within 6 h of symptoms in 94% of cases) and 118 non-ST-elevation myocardial infarction (NSTEMI) patients (percutaneous coronary intervention was performed within 24 h and successful in 73% of cases)...
January 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28160128/blockade-of-the-kinin-b1-receptor-affects-the-cytokine-chemokine-profile-in-rat-brain-subjected-to-autoimmune-encephalomyelitis
#19
Karolina Podsiadło, Grzegorz Sulkowski, Beata Dąbrowska-Bouta, Lidia Strużyńska
Kinins are bioactive peptides which provide multiple functions, including critical regulation of the inflammatory response. Released during tissue injury, kinins potentiate the inflammation which represents a hallmark of numerous neurological disorders, including those of autoimmune origin such as multiple sclerosis (MS). In the present work, we assess the expression of B1 receptor (B1R) in rat brain during the course of experimental autoimmune encephalomyelitis (EAE) which is an animal model of MS. We apply pharmacological inhibition to investigate the role of this receptor in the development of neurological deficits and in shaping the cytokine/chemokine profile during the course of the disease...
February 3, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28159850/protocol-for-a-prospective-observational-study-of-cortical-lower-urinary-tract-control-changes-following-intradetrusor-injection-of-botulinum-toxin-a-in-patients-with-multiple-sclerosis
#20
Rodolfo A Elizondo, Christof Karmonik, Timothy B Boone, Rose Khavari
INTRODUCTION: Multiple sclerosis (MS) is a severe debilitating disease that affects patients' quality of life. Up to 90% of patients with MS will develop lower urinary tract dysfunction within the first 18 years of the disease. If oral pharmacotherapy with anticholinergics, behavioural modifications and pelvic floor physical therapy are unsuccessful, intradetrusor injection of botulinum toxin-A (OnaBotA; Botox Allergan, Dublin, Ireland) is a highly effective option for these patients...
February 3, 2017: BMJ Open
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