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https://www.readbyqxmd.com/read/28108125/interventions-to-support-risk-and-benefit-understanding-of-disease-modifying-drugs-in-multiple-sclerosis-patients-a-systematic-review
#1
REVIEW
Gurpreet K Reen, Eli Silber, Dawn W Langdon
OBJECTIVE: The present review evaluates interventions that have been designed to improve understanding of the complex risk-benefit profiles of disease-modifying drugs (DMDs) in patients with Multiple Sclerosis (MS). METHODS: A systematic search conducted using PubMed, Embase, Google Scholar and PsycINFO identified 15 studies. Interventions which provided treatment information were present across a range of study designs. A narrative synthesis was conducted due to heterogeneity of research findings...
December 28, 2016: Patient Education and Counseling
https://www.readbyqxmd.com/read/28107525/longitudinal-testing-of-olfactory-and-gustatory-function-in-patients-with-multiple-sclerosis
#2
Florian Cornelius Uecker, Heidi Olze, Hagen Kunte, Christian Gerz, Önder Göktas, Lutz Harms, Felix Alexander Schmidt
BACKGROUND: The aim of the study was to investigate changes of the olfactory and gustatory capacity in patients with multiple sclerosis (MS). METHODOLOGY: 20 MS patients were tested longitudinally for 3 years after initial testing. The Threshold Discrimination Identification test (TDI) was used for subjective olfactometry. Objective olfactometry was performed by registering olfactory evoked potentials (OEP) by EEG. The Taste Strip Test (TST) was used for gustatory testing...
2017: PloS One
https://www.readbyqxmd.com/read/28104260/robot-guided-ankle-sensorimotor-rehabilitation-of-patients-with-multiple-sclerosis
#3
Yunju Lee, Kai Chen, Yupeng Ren, Jongsang Son, Bruce A Cohen, James A Sliwa, Li-Qun Zhang
BACKGROUND: People with multiple sclerosis (MS) often develop symptoms including muscle weakness, spasticity, imbalance, and sensory loss in the lower limbs, especially at the ankle, which result in impaired balance and locomotion and increased risk of falls. Rehabilitation strategies that improve ankle function may improve mobility and safety of ambulation in patients with MS. This pilot study investigated effectiveness of a robot-guided ankle passive-active movement training in reducing motor and sensory impairments and improving balance and gait functions...
January 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28104252/novel-zebrafish-eae-model-a-quick-in-vivo-screen-for-multiple-sclerosis
#4
Pushkar Kulkarni, Swapna Yellanki, Raghavender Medishetti, Dharmarajan Sriram, Uday Saxena, Perumal Yogeeswari
INTRODUCTION: Pre-clinical drug discovery for multiple sclerosis (MS) is a labor intensive activity to perform in rodent models. This is owing to the long duration of disease induction and observation of treatment effects in an experimental autoimmune encephalomyelitis (EAE) model. We propose a novel adult zebrafish based model which offers a quick and simple protocol that can used to screen candidates as a step between in vitro experiments and rodent studies. The experiments conducted for this manuscript were to standardize a suitable model of EAE in adult zebrafish and validate it using known modulators...
January 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28104248/continuous-hemifacial-myokymia-as-the-revealing-symptom-of-demyelinating-disease-of-the-cns
#5
Frédéric London, Nawal Hadhoum, Hélène Zéphir, Patrick Vermersch, Olivier Outteryck
Facial myokymia (FM) is an uncommon involuntary movement, disorder of the musculature supplied by the facial nerve and, characterized by spontaneous undulating, vermicular movements beneath the, skin. It has rarely been described as a form of presentation of multiple, sclerosis. We describe a 31-year-old man presenting with continuous, unilateral facial myokymia as the revealing symptom of a demyelinating, disorder of central nervous system. Brain magnetic resonance imaging, showed an ipsilateral pontine T2/FLAIR hyperintensity close to the, postgenu course of facial nerve, suggestive of a segmental demyelination, of facial nerve causing facial nuclear hyperactivity and resulting in FM...
January 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28101682/synthesis-spectral-and-extended-spectrum-beta-lactamase-studies-of-transition-metal-tetraaza-macrocyclic-complexes
#6
Dinesh Kumar, Nutan Sharma, Manjula Nair
Urinary tract infections commonly occur in humans due to microbial pathogens invading the urinary tract, which can bring about a range of clinical symptoms and potentially fatal sequelae. The present study is aimed at addressing the development of a new antimicrobial agent against extended spectrum beta lactamase (ESBL) producing E. coli bacteria. We have synthesised some biologically potent (NNNN) donor macrocycles (L 1  = dibenzo[f,n]dipyrido[3,4-b:4',3'-j][1,4,9,12]tetraazacyclohexadecine-6,11,18,23(5H,12H, 7H, 24H)-tetraone, and L 2  = 6,12,19,25-tetraoxo-4,6,11,12,16,18,23,24-octahydrotetrabenzo [b,g,k,p][1,5,10,14]tetra azacyclooctadecine-2,13-dicarboxylic acid) and their Ti and Zr metal complexes in alcoholic media using microwave protocol...
January 18, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28097202/distinct-effects-of-obesity-and-puberty-on-risk-and-age-at-onset-of-pediatric-ms
#7
Tanuja Chitnis, Jennifer Graves, Bianca Weinstock-Guttman, Anita Belman, Cody Olsen, Madhusmita Misra, Gregory Aaen, Leslie Benson, Meghan Candee, Mark Gorman, Benjamin Greenberg, Lauren Krupp, Timothy Lotze, Soe Mar, Jayne Ness, John Rose, Jennifer Rubin, Teri Schreiner, Jan Tillema, Amy Waldman, Moses Rodriguez, Charlie Casper, Emmanuelle Waubant
OBJECTIVE: The aim of this study was to examine the relative contributions of body mass index (BMI) and pubertal measures for risk and age of onset of pediatric MS. METHODS: Case-control study of 254 (63% female) MS cases (onset<18 years of age) and 420 (49% female) controls conducted at 14 U.S. Pediatric MS Centers. Sex- and age-stratified BMI percentiles were calculated using CDC growth charts from height and weight measured at enrollment for controls, and within 1 year of onset for MS cases...
December 2016: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28096524/a-case-of-seronegative-limbic-encephalitis-with-multiple-sclerosis-a-possible-overlapping-syndrome
#8
Zerrin Karaaslan, Özlem Mercan, Erdem Tüzün, Handan Mısırlı, Recai Türkoğlu
BACKGROUND Autoimmune encephalitis might coexist in patients with autoimmune demyelinating disorders. CASE REPORT We report on a case of a 45-year-old female multiple sclerosis (MS) patient presenting with acute onset short-term memory loss, altered mental status, inflammatory cerebrospinal fluid (CSF) findings and an MRI lesion on the left temporal lobe. An extensive panel for neuronal autoantibodies proved negative. Neuropsychological symptoms gave a prompt response to immunotherapy but nevertheless control MRI showed left hippocampal atrophy...
January 18, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28093821/decreasing-rates-of-pediatric-bipolar-within-an-outpatient-practice
#9
Daniel Wesemann
PROBLEM: Pediatric bipolar disorder (PBD) prevalence is estimated to be 1-3%. Nationally and internationally, rates of PBD have increased by over 400%. However, in Iowa and at one psychiatric clinic in Iowa, from 2008-2013, there was a decrease in PBD diagnosis of 33 and 51.2% respectively. This study examined the diagnosing practices of PBD by local providers in one outpatient mental health center. METHOD: Parents completed a screening packet to differentiate between PBD and attention deficit hyperactivity disorder (ADHD) using three tools: Child Mania Rating Scale (CMRS), Child Behavior Checklist-Mania Scale (CBCL-MS), and the NICHQ Vanderbilt...
January 16, 2017: Journal of Child and Adolescent Psychiatric Nursing
https://www.readbyqxmd.com/read/28093711/clinical-neurophysiology-of-multiple-sclerosis
#10
Mario Habek, Ivan Adamec, Barbara Barun, Luka Crnošija, Tereza Gabelić, Magdalena Krbot Skorić
Different neurophysiological methods such as evoked potentials (EP), testing of the autonomic nervous system (ANS) or polysomnography have the potential to detect clinically silent lesions or to confirm the existence of an association between a clinical symptom and multiple sclerosis (MS); previously undetected by MRI. Therefore, in the most recent MRI criteria for the diagnosis of MS (MAGNIMS consensus guidelines), neurophysiological confirmation of optic nerve dysfunction (slowed conduction on visual EP), support dissemination in space and, in patients without concurrent visual symptoms, dissemination in time...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28093707/meaning-of-self-in-multiple-sclerosis-implications-for-treatment-and-rehabilitation
#11
Maciej Wilski, Tomasz Tasiemski
Low participation of multiple sclerosis (MS) patients in the therapeutic process is considered a primary area in research on the management of this condition. One of the key research directions is the role of self and self-involvement in MS patients. Clinical symptoms of MS and unpredictability of this condition may affect patients' attitude to their self and self-involvement. Self-image and self-appraisal of one's abilities to cope with the disease exert significant effects not only on patient's emotional status but also on their behavior...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28093705/manipulation-of-oxygen-and-endoplasmic-reticulum-stress-factors-as-possible-interventions-for-treatment-of-multiple-sclerosis-evidence-for-and-against
#12
Paul Eggleton, Gary R Smerdon, Janet E Holley, Nicholas J Gutowski
Multiple sclerosis (MS) is normally considered a chronic inflammatory disease of the central nervous system (CNS), where T-cells breaching the blood brain barrier react against proteins of the axonal myelin sheaths, leading to focal plaques and demyelination in the brain and spinal cord. Many current therapies are immunosuppressive in nature and are designed to target the immune system at an early stage of the disease. But there is no cure and MS may evolve into a neurodegenerative disease, where immunomodulatory treatments appear less effective...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28092018/bladder-dysfunction-in-multiple-sclerosis-a-6-year-follow-up-study
#13
Darija Kisic Tepavcevic, Tatjana Pekmezovic, Irena Dujmovic Basuroski, Sarlota Mesaros, Jelena Drulovic
Bladder dysfunction (BD) is the most common autonomic disturbance in multiple sclerosis, but often overlooked and undertreated. The purpose of this longitudinal study was to explore the changes in the frequency of BD symptoms in MS cohort after a period of 3 and 6 years of follow-up, as well as to investigate the correlations between the presence of BD symptoms and both clinical characteristics and the health-related quality of life (HRQoL) at each subsequent point of estimation. The study population comprises a cohort of 93 patients with MS (McDonald's criteria, 2001)...
January 13, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28091795/mood-spectrum-disorders-and-perception-of-pain
#14
Antonella Ciaramella
: Evaluation of pain perception in chronic pain patients with a concomitant mood-spectrum disorder. DESIGN: The observational retrospective study is based on patient data collected in psychosomatic consultations held at the Gift Institute for Integrative Medicine in Pisa, Italy, from 2002 to 2014. Evoked pain stimulus threshold and tolerance were evaluated using the cold pressor test. Clinical pain intensity and Sensorial, Affective, and Evaluative dimensions were assessed using the Italian Pain Questionnaire, and Anxiety and Depressive symptoms using the Hospital Anxiety Depression Scale...
January 14, 2017: Psychiatric Quarterly
https://www.readbyqxmd.com/read/28089877/permanent-pacemaker-implantation-in-octogenarians-with-unexplained-syncope-and-positive-electrophysiologic-study
#15
Georgios Giannopoulos, Charalampos Kossyvakis, Vasiliki Panagopoulou, Dimitrios Tsiachris, Konstantinos Doudoumis, Maria Mavri, Dimitrios Vrachatis, Konstantinos Letsas, Michael Efremidis, Apostolos Katsivas, John Lekakis, Spyridon Deftereos
BACKGROUND: Syncope is a common problem among the elderly and a permanent pacemaker is a therapeutic option when a bradycardic etiology is revealed. However, the benefit of pacing when no association of symptoms to bradycardia has been shown is not clear, especially in the elderly OBJECTIVES: Aim of this study was to evaluate the effect of pacing on syncope-free mortality in patients ≥80 years old, with unexplained syncope and positive invasive electrophysiologic testing (EPS). METHODS: This was an observational study...
January 12, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28089193/brake-reaction-time-after-hip-arthroscopy-for-femoroacetabular-impingement-and-labral-tear
#16
Angelina M Vera, Naseem Beauchman, Patrick C McCulloch, Brayden J Gerrie, Domenica A Delgado, Joshua D Harris
PURPOSE: To determine if a difference exists in brake reaction time (BRT) before and after hip arthroscopy for femoroacetabular impingement (FAI) and labral tear compared with age- and gender-matched controls. METHODS: Consecutive adult subjects undergoing primary hip arthroscopy were eligible for this prospective investigation. Individuals with symptomatic FAI and labral tear that underwent hip arthroscopy with minimum 8 weeks follow-up were included. BRT was measured using the RT-2S reaction time tester a maximum of 6 weeks preoperatively and every 2 weeks postoperatively for 8 weeks...
January 11, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28077133/t1-and-t2-mapping-for-evaluation-of-myocardial-involvement-in-patients-with-anca-associated-vasculitides
#17
Simon Greulich, Agnes Mayr, Daniel Kitterer, Joerg Latus, Joerg Henes, Hannah Steubing, Philipp Kaesemann, Alexandru Patrascu, Andreas Greiser, Stefan Groeninger, Niko Braun, M Dominik Alscher, Udo Sechtem, Heiko Mahrholdt
BACKGROUND: Myocardial involvement in AAV patients might be silent, presenting with no or nonspecific symptoms, normal ECG, and preserved left-ventricular ejection fraction (LV-EF). Since up to 50% of deaths in these patients may be due to myocardial involvement, a reliable diagnostic tool is warranted. In contrast to LGE-CMR, which has its strengths in detecting focal inflammatory or fibrotic processes, recent mapping techniques are able to detect even subtle, diffuse inflammatory or fibrotic processes...
January 6, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28075566/chilling-stress-upregulates-%C3%AE-linolenic-acid-oxidation-pathway-and-induces-volatiles-of-c6-and-c9-aldehydes-in-mango-fruit
#18
Velu Sivankalyani, Itay Maoz, Oleg Feygenberg, Dalia Maurer, Noam Alkan
Mango-fruit storage period and shelf life are prolonged by cold storage. However, chilling temperature induces physiological and molecular changes, compromising fruit quality. In our previous transcriptomic study of mango fruit, cold storage at suboptimal temperature (5 °C) activated the α-linolenic acid metabolic pathway. To evaluate changes in fruit quality during chilling, we analyzed mango "Keitt" fruit peel volatiles. GC-MS analysis revealed significant modulations in fruit volatiles during storage at suboptimal temperature...
January 11, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28065580/fatigue-favors-in-vitro-th1-and-th17-like-cell-expansion-and-reduces-corticoid-sensitivity-in-ms-patients
#19
Hélcio Alvarenga-Filho, Marisa Salles, Joana Hygino, Thais B Ferreira, Priscila M Sacramento, Clarice Monteiro, Claudia Cristina F Vasconcelos, Regina Maria Papais Alvarenga, Cleonice A M Bento
Fatigue is a common "ghost" symptom in patients with multiple sclerosis (MS), an autoimmune disease mediated by T cells that target myelin antigens of the central nervous system. As fatigue has been associated with inflammatory states, its occurrence may negatively impact MS progression. The aim of this study was to evaluate the impact of fatigue on the cytokine profile of patients with relapsing-remitting (RR) MS. For our study, blood were collected from MS patients in clinical remission phase with (n=15) and without (n=15) fatigue...
December 30, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28063748/aspartylglucosaminuria-caused-by-a-novel-homozygous-mutation-in-the-aga-gene-was-identified-by-an-exome-first-approach-in-a-patient-from-japan
#20
Toshiyuki Yamamoto, Keiko Shimojima, Mayumi Matsufuji, Ryuichi Mashima, Eri Sakai, Torayuki Okuyama
BACKGROUND: Aspartylglucosaminuria (AGU) is an autosomal recessive lysosomal storage disorder caused by a deficiency of the lysosomal enzyme, aspartylglucosaminidase (AGA). This disorder is rare in the general population except in Finland. Since the most characteristic feature of this disorder is a progressive developmental regression, patients often show no specific symptoms in the initial stages, and thus early diagnosis is often challenging. CASE REPORT: We encountered a 16-year-old boy who began to show difficulties in his speech at the age of 6years...
January 4, 2017: Brain & Development
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