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Piper nigrum

Hanmei Li, Sonja Krstin, Shihui Wang, Michael Wink
BACKGROUND: Multidrug resistance (MDR) can develop in cancer cells after treatment with anticancer drugs, mainly due to the overexpression of the ATP-binding cassette (ABC) transporters. We analyzed the ability of two pungent-tasting alkaloids-capsaicin and piperine from Capsicum frutescens and Piper nigrum , respectively-to reverse multidrug resistance in the cancer cell lines Caco-2 and CEM/ADR 5000, which overexpress P-glycoprotein (P-gp) and other ABC transporters. METHODS: The MTT assay was first used to determine the cytotoxicity of doxorubicin, the alkaloids, and digitonin alone, and then their combinations...
March 2, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Douglas Silva Parreira, Ricardo Alcántara-de la Cruz, Germano Leão Demolin Leite, Francisco de Souza Ramalho, José Cola Zanuncio, José Eduardo Serrão
The use of chemical insecticides and non-selective natural products authorized for use in organic farming may reduce the effectiveness of egg parasitoids. The side-effects of ten plant essential oils on immature stages of Trichogramma pretiosum were evaluated. Carapa guianensis, Origanum vulgare and Zingiber officinalle during the F1 generation, and Azadirachtin and Mentha piperita in the F2 generation were slightly harmful (class II: 30-79%) to the emergence of this parasitoid. All essential oils affected the longevity of females of the F1 and F2 generations...
February 14, 2018: Chemosphere
Chellappan Shobana, Basuvannan Rangasamy, Rama Krishnan Poopal, Sivashankar Renuka, Mathan Ramesh
The aim of the present investigation is to assess the sublethal toxicity of biologically synthesized silver nanoparticles (Ag NPs) in Indian major carp Labeo rohita. Ag NPs used in the study were synthesized by using AgNO 3 with aqueous leaf extract of Piper nigrum. Median lethal concentration (LC 50 ) of synthesized Ag NPs was determined for 96 h (25 μg/L); 2.5 μg/L (1/10th LC 50 ) and 5 μg/L (1/5th LC 50 ) were taken as sublethal concentrations to evaluate the toxicity for 35 days. The results of the TEM, SEM, and EDX analyses revealed that Ag NPs were considerably accumulated in the gill, liver, and kidney of fish at both concentrations (2...
February 14, 2018: Environmental Science and Pollution Research International
Fenglin Gu, Feifei Huang, Guiping Wu, Hongying Zhu
Black pepper ( Piper nigrum L.) is the most widely used spice in the world. Blackening is considered to be beneficial and important in the processing of black pepper because it contributes to its color and flavor. The purpose of this paper is to investigate polyphenol oxidation as well as the chlorophyll and vitamin C (VC) degradation in the blackening of Piper nigrum L. Black pepper was produced by four methods, and changes in polyphenols, chlorophyll and VC were studied by high performance liquid chromatography (HPLC) and ultraviolet-visible and visible (UV-Vis) spectrophotometry...
February 9, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Emma R Collings, M Carmen Alamar Gavidia, Katherine Cools, Sally Redfern, Leon A Terry
Application of UV-C has been shown to enhance the biochemical profile of various plant materials. This could be used to increase biochemical load, reducing the amount of material required but still impart equivalent flavour. As spices, such as black pepper (Piper nigrum L.), are typically dried to low moisture content to create a stable product for transportation and storage, little work has explored the use of modern postharvest treatments to enhance flavour. In this work, fresh P. nigrum berries were exposed to four UV-C doses (0, 1, 5 and 15 kJ m-2) and subsequently stored at 5 °C for ca...
February 2018: Postharvest Biology and Technology
Zeinab Mahmoudpour, Hoda Shirafkan, Morteza Mojahedi, Narjes Gorji, Seyyed Ali Mozaffarpur
Background: Functional gastrointestinal diseases are common in general populations and comprise more than 40% visits to gastroenterologists. Treatment options of gastrointestinal diseases have been limited. There are a few medications for functional gastrointestinal diseases and some of medications are not available in the market or in the place where the patient lives. Traditional Persian medicine (TPM) is a branch of alternative and traditional medicine based on individual viewpoint and humoral theory, focuses on lifestyle modification and uses natural products to manage the patients...
2018: Caspian Journal of Internal Medicine
Kelly J Figueroa-Lopez, Margarita María Andrade-Mahecha, Olga Lucía Torres-Vargas
This study focused on the development of gelatin-based films with incorporation of microcrystalline cellulose as reinforcement material. Clove (Syzygium aromaticum), nutmeg (Myristica fragrans), and black pepper (Piper nigrum) oleoresins containing antimicrobial compounds of natural origin were incorporated into the films. The mechanical, thermal, optical, and structural properties, as well as color, seal strength and permeability to water vapor, light, and oil of the films were determined. Adding oleoresins to the gelatin matrix increased the elongation of the material and significantly diminished its permeability to water vapor and oil...
January 19, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Christopher A Bell, Howard J Atkinson, Alan C Andrade, Hoa X Nguyen, I Gede Swibawa, Catherine Lilley, James McCarthy, Peter Urwin
Coffee yields are adversely affected by plant-parasitic nematodes and the pathogens are largely under-reported because a simple and reliable identification method is not available. We describe a PCR-based approach to rapidly detect and quantify the major Pratylenchus and Meloidogyne nematode species that are capable of parasitising coffee. The procedure was applied to soil samples obtained from a number of coffee farms in Brazil, Vietnam and Indonesia to assess the prevalence of these species associated both with coffee (Coffea arabica and C...
January 1, 2018: Phytopathology
Zhehao Jin, Moonhyuk Kwon, Ah-Reum Lee, Dae-Kyun Ro, Juraithip Wungsintaweekul, Soo-Un Kim
To identify terpene synthases (TPS) responsible for the biosynthesis of the sesquiterpenes that contribute to the characteristic flavors of black pepper (Piper nigrum), unripe peppercorn was subjected to the Illumina transcriptome sequencing. The BLAST analysis using amorpha-4,11-diene synthase as a query identified 19 sesquiterpene synthases (sesqui-TPSs), of which three full-length cDNAs (PnTPS1 through 3) were cloned. These sesqui-TPS cDNAs were expressed in E. coli to produce recombinant enzymes for in vitro assays, and also expressed in the engineered yeast strain to assess their catalytic activities in vivo...
December 14, 2017: Archives of Biochemistry and Biophysics
Palaniyandi Umadevi, Muthuswamy Anandaraj, Vivek Srivastav, Sailas Benjamin
Employing Illumina Hiseq whole genome metagenome sequencing approach, we studied the impact of Trichoderma harzianum on altering the microbial community and its functional dynamics in the rhizhosphere soil of black pepper (Piper nigrum L.). The metagenomic datasets from the rhizosphere with (treatment) and without (control) T. harzianum inoculation were annotated using dual approach, i.e., stand alone and MG-RAST. The probiotic application of T. harzianum in the rhizhosphere soil of black pepper impacted the population dynamics of rhizosphere bacteria, archae, eukaryote as reflected through the selective recruitment of bacteria [Acidobacteriaceae bacterium (p=1...
November 29, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
Shirlley F M da Luz, Lydia F Yamaguchi, Massuo J Kato, Oriel F de Lemos, Luciana P Xavier, José Guilherme S Maia, Alessandra de R Ramos, William N Setzer, Joyce Kelly do R da Silva
Bragantina and Cingapura are the main black pepper ( Piper nigrum L.) cultivars and the Pará state is the largest producer in Brazil with about 90% of national production, representing the third largest production in the world. The infection of Fusarium solani f. sp. piperis , the causal agent of Fusarium disease in black pepper, was monitored on the cultivars Bragantina (susceptible) and Cingapura (tolerant), during 45 days' post infection (dpi). Gas Chromatography-Mass spectrometry (GC-MS) analysis of the volatile concentrates of both cultivars showed that the Bragantina responded with the production of higher contents of α-bisabolol at 21 dpi and a decrease of elemol, mostly at 30 dpi; while Cingapura displayed an decrease of δ-elemene production, except at 15 dpi...
December 7, 2017: International Journal of Molecular Sciences
Balendra Sah, Kamalraj Subban, Jayabaskaran Chelliah
In this study, we have isolated an endophytic fungal strain Lasiodiplodia theobromae from non-Taxus host plant Piper nigrum. The strain L. theobromae identity was confirmed by morphological characteristics and internal transcribed spacer sequence analysis. Taxol produced by L. theobromae was observed to be identical to the authentic taxol as analyzed by chromatography and spectroscopy methods. The quantity of taxol produced by the fungus was estimated to be 247 μg L-1, and fungal taxol showed potent cytotoxic activity towards cancer cell line...
December 29, 2017: FEMS Microbiology Letters
Kornsit Wiwattanarattanabut, Suwan Choonharuangdej, Theerathavaj Srithavaj
Introduction: Cariogenic bacteria including mutans streptococci and lactobacilli are partly but significantly involved in dental caries development. An effective prevention strategy against dental caries is to decrease the accumulation of this microbiota either in planktonic or in biofilm form. Aim: To examine the antimicrobial and anti-plaque effects of some culinary herbs (spices), so the herbs are plausibly used as alternative and effective herbal plaque control supplements to promote good oral health...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
Balaji Meriga, Brahmanaidu Parim, Venkata Rao Chunduri, Ramavat Ravindar Naik, Harishankar Nemani, Pothani Suresh, Saravanan Ganapathy, Satthi Babu Vvu
Background: Black pepper or Piper nigrum is a well-known spice, rich in a variety of bioactive compounds, and widely used in many cuisines across the world. In the Indian traditional systems of medicine, it is used to treat gastric and respiratory ailments. The purpose of this investigation is to study the antihyperlipidemic and antiobesity effects of piperonal in high-fat diet (HFD)-induced obese rats. Methods: Piperonal, an active constituent of Piper nigrum seeds, was isolated and confirmed by HPLC,1 H and13 C NMR spectroscopy...
2017: Nutrition & Metabolism
Shu-Zhai Han, Hong-Xia Liu, Lin-Qing Yang, Li-de Cui, Yun Xu
Piperine (PP), an alkaloid from black and long peppers (Piper nigrum Linn &Piper longum Linn), exhibits antitumor activities in vitro and in vivo. We investigated the ability of piperine (PP) to reverse the drug resistance of human cervical cancer cells. In our study, the cervica cancer cells resistant to mitomycin-C (MMC) treatment were used. We found the growth inhibitory effects of piperine on human cervical cancer cell, which were resistant to MMC. Piperine and MMC co-treatment resulted in a dose-dependent suppression of the cell proliferation...
December 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Rafaelle Vinturelle, Camila Mattos, Jéssica Meloni, Jeane Nogueira, Maria Júlia Nunes, Itabajara S Vaz, Leandro Rocha, Viviane Lione, Helena C Castro, Evelize Folly das Chagas
The present research aimed to study the chemical composition and acaricidal activity of Citrus limonum and Piper nigrum essential oils against the cattle tick Rhipicephalus microplus. GC-MS analysis of C. limonum essential oil showed limonene (50.3%), β-pinene (14.4%), and γ-terpinene (11.7%) as the major components; P. nigrum oil was mainly composed of β-caryophyllene (26.2%), σ-ocymene (5.8%), and α-pinene (5.5%). Acaricide activity was evaluated at concentrations of 2.5, 5.0, and 10.0% (v/v) of each plant oil, as well as 1 : 1 combination of both oils (5% : 5%, 2...
2017: Biochemistry Research International
Thi Tho Bui, Chun Hua Piao, Chang Ho Song, Hee Soon Shin, Dong-Hwa Shon, Ok Hee Chai
Piper nigrum (Piperaceae) is commonly used as a spice and traditional medicine in many countries. P. nigrum has been reported to have anti-oxidant, anti-bacterial, anti-tumor, anti-mutagenic, anti-diabetic, and anti-inflammatory properties. However, the effect of P. nigrum on allergic asthma has not been known. This study investigated the effect of P. nigrum ethanol extracts (PNE) on airway inflammation in asthmatic mice model. In the ovalbumin (OVA)-induced allergic asthma model, we analysed the number of inflammatory cells and cytokines production in bronchoalveolar lavage fluid (BALF) and lung tissue; histological structure; as well as the total immunoglobulin (Ig)E, anti-OVA IgE, anti-OVA IgG1 and histamine levels in serum...
October 16, 2017: Cellular Immunology
Young Sook Yun, Sachie Noda, Shigeru Takahashi, Yuji Takahashi, Hideshi Inoue
Black pepper (Piper nigrum) contains a variety of alkamides. Among them, piperine has been reported to have antidepressant-like effects in chronically stressed mice, but little is known about the biological activity of other alkamides. In this study, we investigated the effects of alkamides from white pepper (P. nigrum) on neuronal cells. Twelve alkamides were isolated from white pepper MeOH extracts, and their chemical structures were identified by NMR and MS analyses. The compounds were subjected to assays using the luciferase-reporter gene under the control of the BDNF promoter or cAMP response element in mouse neuroblastoma Neuro-2a cells...
October 23, 2017: Journal of Natural Medicines
Yoonjee Chang, Soo-Hyun Lee, Ja Hyun Na, Pahn-Shick Chang, Jaejoon Han
The purpose of this study was to develop an anti-insect pest repellent sachet to prevent Sitophilus oryzae (L.) (Coleoptera: Curculionidae) contamination in grain packaging. The anti-insect pest activities of essential oils (EOs) from garlic (Allium Sativum), ginger (Zingiber Officinalis), black pepper (Piper nigrum), onion (Allium cepa), and fennel (Foeniculum vulgare) as well as major compounds (allyl disulfide, AD; allyl mercaptan, AM) isolated from of garlic and onion (AD and AM) were measured against S...
October 14, 2017: Journal of Food Science
Inés Reynoso-Moreno, Israel Najar-Guerrero, Noé Escareño, Mario Eduardo Flores-Soto, Jürg Gertsch, Juan Manuel Viveros-Paredes
Guineensine is a dietary N-isobutylamide widely present in black and long pepper (Piper nigrum and Piper longum) previously shown to inhibit cellular endocannabinoid uptake. Given the role of endocannabinoids in inflammation and pain reduction, here we evaluated guineensine in mouse models of acute and inflammatory pain and endotoxemia. Significant dose-dependent anti-inflammatory effects (95.6 ± 3.1% inhibition of inflammatory pain at 2.5 mg/kg ip and 50.0 ± 15.9% inhibition of edema formation at 5 mg/kg ip) and acute analgesia (66...
October 25, 2017: Journal of Agricultural and Food Chemistry
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