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Piper nigrum

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https://www.readbyqxmd.com/read/29123924/in-vitro-evaluation-of-essential-oils-derived-from-piper-nigrum-piperaceae-and-citrus-limonum-rutaceae-against-the-tick-rhipicephalus-boophilus-microplus-acari-ixodidae
#1
Rafaelle Vinturelle, Camila Mattos, Jéssica Meloni, Jeane Nogueira, Maria Júlia Nunes, Itabajara S Vaz, Leandro Rocha, Viviane Lione, Helena C Castro, Evelize Folly das Chagas
The present research aimed to study the chemical composition and acaricidal activity of Citrus limonum and Piper nigrum essential oils against the cattle tick Rhipicephalus microplus. GC-MS analysis of C. limonum essential oil showed limonene (50.3%), β-pinene (14.4%), and γ-terpinene (11.7%) as the major components; P. nigrum oil was mainly composed of β-caryophyllene (26.2%), σ-ocymene (5.8%), and α-pinene (5.5%). Acaricide activity was evaluated at concentrations of 2.5, 5.0, and 10.0% (v/v) of each plant oil, as well as 1 : 1 combination of both oils (5% : 5%, 2...
2017: Biochemistry Research International
https://www.readbyqxmd.com/read/29066080/piper-nigrum-extract-ameliorated-allergic-inflammation-through-inhibiting-th2-th17-responses-and-mast-cells-activation
#2
Thi Tho Bui, Chun Hua Piao, Chang Ho Song, Hee Soon Shin, Dong-Hwa Shon, Ok Hee Chai
Piper nigrum (Piperaceae) is commonly used as a spice and traditional medicine in many countries. P. nigrum has been reported to have anti-oxidant, anti-bacterial, anti-tumor, anti-mutagenic, anti-diabetic, and anti-inflammatory properties. However, the effect of P. nigrum on allergic asthma has not been known. This study investigated the effect of P. nigrum ethanol extracts (PNE) on airway inflammation in asthmatic mice model. In the ovalbumin (OVA)-induced allergic asthma model, we analysed the number of inflammatory cells and cytokines production in bronchoalveolar lavage fluid (BALF) and lung tissue; histological structure; as well as the total immunoglobulin (Ig)E, anti-OVA IgE, anti-OVA IgG1 and histamine levels in serum...
October 16, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/29063362/piperine-like-alkamides-from-piper-nigrum-induce-bdnf-promoter-and-promote-neurite-outgrowth-in-neuro-2a-cells
#3
Young Sook Yun, Sachie Noda, Shigeru Takahashi, Yuji Takahashi, Hideshi Inoue
Black pepper (Piper nigrum) contains a variety of alkamides. Among them, piperine has been reported to have antidepressant-like effects in chronically stressed mice, but little is known about the biological activity of other alkamides. In this study, we investigated the effects of alkamides from white pepper (P. nigrum) on neuronal cells. Twelve alkamides were isolated from white pepper MeOH extracts, and their chemical structures were identified by NMR and MS analyses. The compounds were subjected to assays using the luciferase-reporter gene under the control of the BDNF promoter or cAMP response element in mouse neuroblastoma Neuro-2a cells...
October 23, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/29030875/protection-of-grain-products-from-sitophilus-oryzae-l-contamination-by-anti-insect-pest-repellent-sachet-containing-allyl-mercaptan-microcapsule
#4
Yoonjee Chang, Soo-Hyun Lee, Ja Hyun Na, Pahn-Shick Chang, Jaejoon Han
The purpose of this study was to develop an anti-insect pest repellent sachet to prevent Sitophilus oryzae (L.) (Coleoptera: Curculionidae) contamination in grain packaging. The anti-insect pest activities of essential oils (EOs) from garlic (Allium Sativum), ginger (Zingiber Officinalis), black pepper (Piper nigrum), onion (Allium cepa), and fennel (Foeniculum vulgare) as well as major compounds (allyl disulfide, AD; allyl mercaptan, AM) isolated from of garlic and onion (AD and AM) were measured against S...
October 14, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28942644/an-endocannabinoid-uptake-inhibitor-from-black-pepper-exerts-pronounced-anti-inflammatory-effects-in-mice
#5
Inés Reynoso-Moreno, Israel Najar-Guerrero, Noé Escareño, Mario Eduardo Flores-Soto, Jürg Gertsch, Juan Manuel Viveros-Paredes
Guineensine is a dietary N-isobutylamide widely present in black and long pepper (Piper nigrum and Piper longum) previously shown to inhibit cellular endocannabinoid uptake. Given the role of endocannabinoids in inflammation and pain reduction, here we evaluated guineensine in mouse models of acute and inflammatory pain and endotoxemia. Significant dose-dependent anti-inflammatory effects (95.6 ± 3.1% inhibition of inflammatory pain at 2.5 mg/kg ip and 50.0 ± 15.9% inhibition of edema formation at 5 mg/kg ip) and acute analgesia (66...
October 25, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28930228/interaction-of-plant-extracts-with-central-nervous-system-receptors
#6
REVIEW
Kenneth Lundstrom, Huyen Thanh Pham, Long Doan Dinh
Background: Plant extracts have been used in traditional medicine for the treatment of various maladies including neurological diseases. Several central nervous system receptors have been demonstrated to interact with plant extracts and components affecting the pharmacology and thereby potentially playing a role in human disease and treatment. For instance, extracts from Hypericum perforatum (St. John's wort) targeted several CNS receptors. Similarly, extracts from Piper nigrum, Stephania cambodica, and Styphnolobium japonicum exerted inhibition of agonist-induced activity of the human neurokinin-1 receptor...
February 23, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28815601/antimicrobial-synergism-and-cytotoxic-properties-of-citrus-limon-l-piper-nigrum-l-and-melaleuca-alternifolia-maiden-and-betche-cheel-essential-oils
#7
Miloš M Nikolić, Katarina K Jovanović, Tatjana Lj Marković, Dejan Lj Marković, Nevenka N Gligorijević, Siniša S Radulović, Marina Kostić, Jasmina M Glamočlija, Marina D Soković
OBJECTIVES: The chemical composition, antimicrobial and synergistic effect, and cytotoxic activity of Citrus limon (lemon), Piper nigrum (green pepper) and Melaleuca alternifoila (tea tree) essential oils (EOs) were investigated. METHODS: Chemical analyses of essential oils were tested by GC-FID and GC-MS spectroscopy. The antimicrobial activity assay was conducted using microdilution method against several oral bacteria and Candida spp. originating from the humans with oral disorders...
August 17, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28757226/preparation-and-physicochemical-characterization-of-ingredients-of-indian-traditional-medicine-mahamrutyunjaya-rasa
#8
Pallavi Rai, Sadhana J Rajput
BACKGROUND: Mahamrutyunjaya rasa is an ayurvedic formulation used in the treatment of cardiac disorders. It contains the purified roots of Visa (Aconitum ferox), Brihati (Solanum indicum), fruits of Pippali Kana (Piper longum), Marica (Piper nigrum), Gandhaka (Sulfur), Hingula (Cinnabar) and Tankana (Sodium metaborate) as per Bhaishajya Ratnavali. The purification (shodhana) process changes the physiochemical properties of the raw materials which need to be studied and understood. OBJECTIVE: The present work aims to perform a comprehensive physicochemical characterization of raw materials, intermediates and the final product obtained during purification, using modern analytical techniques...
July 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/28694780/the-effect-of-pungent-and-tingling-compounds-from-piper-nigrum-l-on-background-k-currents
#9
Leopoldo R Beltrán, Corinna Dawid, Madeline Beltrán, Janina Levermann, Sascha Titt, Sini Thomas, Viktoria Pürschel, Miriam Satalik, Günter Gisselmann, Thomas Hofmann, Hanns Hatt
Black peppercorns (Piper nigrum L.) elicit a pungent and tingling oral impression. Their pungency is partially explained by the agonist activity of some of their active principles, especially piperine, on TRP channels. However, we recently showed that piperine, as well as other pungent compounds, also possess a marked effect on two-pore domain (KCNK, K2P) K(+) channels. Members of this family play a key role in maintaining the resting membrane potential of excitable cells. Interestingly, tingling compounds have been shown to induce neuronal excitation by inhibiting KCNK channels...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28641526/biology-oriented-synthesis-bios-of-piperine-derivatives-and-their-comparative-analgesic-and-antiinflammatory-activities
#10
Ammar Yasir, Saiqa Ishtiaq, Muhammad Jahangir, Muhammad Ajaib, Uzma Salar, Khalid Mohammed Khan
BACKGROUND: Serious side effects such as gastric intestinal ulcer, bleeding etc. are associated with most of the antiinflammatory and analgesic drugs. So there is a need to search novel, potent, and safer antiinflammatory and analgesic drug. METHOD: Based on "biology-oriented synthesis approach", piperine alkaloid was isolated from Piper nigrum L. and some derivatives of piperine having azomethine, sulfamoyl, propanoyl, acetamoyl and heterocyclic oxadiazole were synthesized...
June 22, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28620299/the-alkamide-trans-pellitorine-targets-ppar%C3%AE-via-trpv1-and-trpa1-to-reduce-lipid-accumulation-in-developing-3t3-l1-adipocytes
#11
Barbara Lieder, Mathias Zaunschirm, Ann-Katrin Holik, Jakob P Ley, Joachim Hans, Gerhard E Krammer, Veronika Somoza
Adipose tissue is an important endocrine organ in the human body. However, pathological overgrowth is associated with chronic illness. Regulation of adipogenesis and maturation of adipocytes via bioactive compounds in our daily diet has been in focus of research in the past years and showed promising results for agonists of the ion channels transient receptor potential channel (TRP) V1 and A1. Here, we investigated the anti-adipogenic potential and underlying mechanisms of the alkamide trans-pellitorine present in Piper nigrum via TRPV1 and TRPA1 in 3T3-L1 cells...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28611658/neuroprotective-and-anti-aging-potentials-of-essential-oils-from-aromatic-and-medicinal-plants
#12
REVIEW
Muhammad Ayaz, Abdul Sadiq, Muhammad Junaid, Farhat Ullah, Fazal Subhan, Jawad Ahmed
The use of essential oils (EOs) and their components is known since long in traditional medicine and aromatherapy for the management of various diseases, and is further increased in the recent times. The neuroprotective and anti-aging potentials of EOs and their possible mechanism of actions were evaluated by numerous researchers around the globe. Several clinically important EOs and their components from Nigella sativa, Acorus gramineus, Lavandula angustifolia, Eucalyptus globulus, Mentha piperita, Rosmarinus officinalis, Jasminum sambac, Piper nigrum and so many other plants are reported for neuroprotective effects...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28586745/-kusunokinin-and-piperloguminine-from-piper-nigrum-an-alternative-option-to-treat-breast-cancer
#13
Somchai Sriwiriyajan, Yaowapa Sukpondma, Theera Srisawat, Siribhorn Madla, Potchanapond Graidist
Several studies have reported that active compounds isolated from Piper nigrum possess anticancer properties. However, there are no data on anticancer activity of (-)-kusunokinin and piperlonguminine. The purposes of this study were to isolate active compounds from P. nigrum and identify the molecular mechanisms underlying growth and apoptosis pathway in breast cancer cells. Two bioactive compounds, (-)-kusunokinin and piperlonguminine, were isolated from P. nigrum. Cytotoxicity and the molecular mechanism were measured by methyl thiazolyl tetrazolium (MTT) assay, flow cytometry and Western blot analysis...
August 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28572957/effect-of-spices-formulations-on-the-physicochemical-and-sensory-properties-of-nnam-gon-a-cameroonian-dish-prepared-with-cucurbitaceae-seeds
#14
Josiane E Manejo Djiogue, Richard M Nguimbou, Leopold N Tatsadjieu, Yannick D Mang, Nicolas Y Njintang
Nnam gon, a cake made by steam cooking a mixture of Cucurbitaceae seeds paste and others ingredients specially spices, is a highly prized dish in Central African region. A preliminary investigation conducted as part of this study highlighted that formulations used in the processing of Nnam gon vary according to the spices used. This study was carried out to determine the best formulation for the preparation of this dish. For this purpose, Nnam gon samples were produced from four formulations which differ according to the number of spices used: F0 (no spices); F1 (0...
May 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28550736/piperine-attenuates-uv-r-induced-cell-damage-in-human-keratinocytes-via-nf-kb-bax-bcl-2-pathway-an-application-for-photoprotection
#15
Ankit Verma, Hari N Kushwaha, Ajeet K Srivastava, Saumya Srivastava, Naseem Jamal, Kriti Srivastava, Ratan Singh Ray
Chronic ultraviolet radiation (UV-R) exposure causes skin disorders like erythema, edema, hyperpigmentation, photoaging and photocarcinogenesis. Recent research trends of researchers have focused more attention on the identification and use of photo stable natural agents with photoprotective properties. Piperine (PIP), as a plant alkaloid, is an important constituent present in black pepper (Piper nigrum), used widely in ayurvedic and other traditional medicines and has broad pharmacological properties. The study was planned to photoprotective efficacy of PIP in human keratinocyte (HaCaT) cell line...
July 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28378160/the-dynamic-microbiota-profile-during-pepper-piper-nigrum-l-peeling-by-solid-state-fermentation
#16
Qisong Hu, Jiachao Zhang, Chuanbiao Xu, Congfa Li, Sixin Liu
White pepper (Piper nigrum L.), a well-known spice, is the main pepper processing product in Hainan province, China. The solid-state method of fermentation can peel pepper in a highly efficient manner and yield high-quality white pepper. In the present study, we used next-generation sequencing to reveal the dynamic changes in the microbiota during pepper peeling by solid-state fermentation. The results suggested that the inoculated Aspergillus niger was dominant throughout the fermentation stage, with its strains constituting more than 95% of the fungi present; thus, the fungal community structure was relatively stable...
June 2017: Current Microbiology
https://www.readbyqxmd.com/read/28370557/characterization-of-piperine-metabolites-in-rats-by-ultra-high-performance-liquid-chromatography-with-electrospray-ionization-quadruple-time-of-flight-tandem-mass-spectrometry
#17
Tingting Gao, Haiping Xue, Lu Lu, Tong Zhang, Han Han
RATIONALE: Piperine is a major constituent of Piper nigrum L. and is a naturally bioactive alkaloid. Structural changes in piperine have been shown to result in different biological effects. The present study aims to investigate piperine metabolites in rat plasma, bile, urine, and feces after oral administration. METHODS: The metabolic pathway of piperine in vivo was investigated using ultra-high-performance liquid chromatography (UHLPC) combined with electrospray ionization quadruple time-of-flight tandem mass spectrometry (QTOF-MS)...
June 15, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28349654/piperolein-b-and-piperchabamide-d-isolated-from-black-pepper-piper-nigrum-l-as-larvicidal-compounds-against-the-diamondback-moth-plutella-xylostella
#18
Ki Seon Hwang, Young Kook Kim, Kee Woong Park, Young Tae Kim
BACKGROUND: There is growing demand for the development of alternative pest control agents that are effective as well as non-toxic to human health and the environment. Plant protection products derived from plant extracts are an eco-friendly alternative to synthetic pesticides. The aim of this study was to identify larvicidal compounds isolated from a natural source against Plutella xylostella L. In a larvicidal activity assay, several solvent fractions from the methanol extract of Piper nigrum L...
March 28, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28326461/toxicity-and-detoxification-mechanism-of-black-pepper-and-its-major-constituent-in-controlling-rhynchophorus-ferrugineus-olivier-curculionidae-coleoptera
#19
A Hussain, M Rizwan-Ul-Haq, H Al-Ayedh, A M Aljabr
The survival, feeding response, and detoxification mechanism of Rhynchophorus ferrugineus Olivier, a key pest responsible for destruction of date palm, was examined with different extracts of Piper nigrum and its major constituent (piperine) identified by GC-MS. In the present study, toxicity of different extracts of black pepper was evaluated by incorporating diffferent doses of extracts into the artificial diet of red palm weevil larvae. All extracts showed dose-dependent insecticidal activity to the tested eighth-instar red palm weevil larvae...
December 2017: Neotropical Entomology
https://www.readbyqxmd.com/read/28314475/pharmacokinetic-based-study-on-lagged-stimulation-of-curcumae-longae-rhizoma-piper-nigrum-couplet-in-their-main-active-components-metabolism-using-uplc-ms-ms
#20
Zhao Chen, Dongmei Sun, Xiaoli Bi, Xiaohui Zeng, Wenhui Luo, Dake Cai, Qiaohuang Zeng, Aili Xu
BACKGROUND: Curcumae Longae Rhizoma is one of the commonly used traditional Chinese medicines, which has multiple biological activities such as relieving stagnation and stasis, pain alleviation, curing amenorrhea and wounds. However, its main active component-curcumin has poor absorption and very fast metabolism in body. To solve this problem, Piper nigrum was introduced for its ability to strengthen bioavailability of other compounds. PURPOSE: In most cases of TCM couplets, all ingredients were prepared and taken simultaneously, which in our opinion did not take full advantage of their interactions...
April 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
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