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Piper nigrum

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https://www.readbyqxmd.com/read/28326461/toxicity-and-detoxification-mechanism-of-black-pepper-and-its-major-constituent-in-controlling-rhynchophorus-ferrugineus-olivier-curculionidae-coleoptera
#1
A Hussain, M Rizwan-Ul-Haq, H Al-Ayedh, A M Aljabr
The survival, feeding response, and detoxification mechanism of Rhynchophorus ferrugineus Olivier, a key pest responsible for destruction of date palm, was examined with different extracts of Piper nigrum and its major constituent (piperine) identified by GC-MS. In the present study, toxicity of different extracts of black pepper was evaluated by incorporating diffferent doses of extracts into the artificial diet of red palm weevil larvae. All extracts showed dose-dependent insecticidal activity to the tested eighth-instar red palm weevil larvae...
March 21, 2017: Neotropical Entomology
https://www.readbyqxmd.com/read/28314475/pharmacokinetic-based-study-on-lagged-stimulation-of-curcumae-longae-rhizoma-piper-nigrum-couplet-in-their-main-active-components-metabolism-using-uplc-ms-ms
#2
Zhao Chen, Dongmei Sun, Xiaoli Bi, Xiaohui Zeng, Wenhui Luo, Dake Cai, Qiaohuang Zeng, Aili Xu
BACKGROUND: Curcumae Longae Rhizoma is one of the commonly used traditional Chinese medicines, which has multiple biological activities such as relieving stagnation and stasis, pain alleviation, curing amenorrhea and wounds. However, its main active component-curcumin has poor absorption and very fast metabolism in body. To solve this problem, Piper nigrum was introduced for its ability to strengthen bioavailability of other compounds. PURPOSE: In most cases of TCM couplets, all ingredients were prepared and taken simultaneously, which in our opinion did not take full advantage of their interactions...
April 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28302020/olfactory-loss-management-in-view-of-avicenna-focus-on-neuroprotective-plants
#3
Farnaz Sinaei, Seyed Ahmad Emami, Amirhossein Sahebkar, Behjat Javadi
BACKGROUND: Loss of olfaction can cause noticeable reduction in general quality of life. Only a small portion of patients with olfactory loss respond to current medications. Thus, development of novel therapeutic strategies seems to be necessary. Looking into traditional medical knowledge can be of great value in addressing useful remedies. Traditional Persian Medicine (TPM) has been practiced in Persia for more than 2000 years. Avicenna is the most eminent Persian physician. OBJECTIVE: To survey Avicenna's views on etiology and management of olfactory loss and to search for relevant modern pharmacological data...
March 16, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28254575/in-vivo-cough-suppressive-activity-of-pectic-polysaccharide-with-arabinogalactan-type-ii-side-chains-of-piper-nigrum-fruits-and-its-synergistic-effect-with-piperine
#4
Sadhana Khawas, Gabriela Nosáľová, Sujay Kumar Majee, Kanika Ghosh, Washim Raja, Veronika Sivová, Bimalendu Ray
Piper nigrum L. fruits are not only a prized spice, but also highly valued therapeutic agent that heals many ailments including asthma, cold and respiratory problems. Herein, we have investigated structural features and in vivo antitussive activity of three fractions isolated from Piper nigrum fruits. The water extract (PN-WE) upon fractionation with EtOH yielded two fractions: a soluble fraction (PN-eSf) and a precipitated (PN-ePf) one. The existence of a pectic polysaccharide with arabinogalactan type II side chains (147kDa) in PN-ePf and piperine in PN-eSf were revealed...
February 28, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28251408/in-vitro-assessment-of-the-acaricidal-activity-of-piper-longum-piper-nigrum-%C3%A2-and-zingiber-officinale-extracts-against-hyalomma-anatolicum-ticks
#5
Nirbhay K Singh, S P S Saini, Harkirat Singh, Jyoti, S K Sharma, S S Rath
Ticks and tick-borne diseases are a major constraint for the sustainable cattle industry in the tropical and subtropical regions including the Indian subcontinent. The development of resistance to most of the commonly used acaricides leads to an attempt to screen plant extracts and their combinations for their possible acaricidal activity to develop an eco-friendly tick control alternative. An alcoholic and various aqueous extracts of Piper longum, Piper nigrum and Zingiber officinale and their combinations were evaluated for acaricidal activity against the three-host ixodid tick, Hyalomma anatolicum by larval immersion test using 14-21 days old unfed larvae...
March 1, 2017: Experimental & Applied Acarology
https://www.readbyqxmd.com/read/28251112/in-vitro-anticancer-activity-of-ethanolic-extracts-of-piper-nigrum-against-colorectal-carcinoma-cell-lines
#6
Akila Prashant, Chandini Rangaswamy, Anshu Kumar Yadav, Varun Reddy, M N Sowmya, Subbarao Madhunapantula
BACKGROUND: Piper nigrum (PN) is well known for its cytotoxic and pharmacological benefits. However, there is minimal documented evidence about its cytotoxic efficacy against colorectal carcinoma. We therefore sought to procure a precisely quantitative and qualitative result, pertaining the efficacy of an ethanolic extract of PN (EEPN) against colorectal carcinoma. MATERIALS AND METHODS: EEPN was prepared by subjecting dried PN seeds to gradient ethanol fractionation...
January 2017: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/28249821/ethno-veterinary-practices-in-southern-india-for-captive-asian-elephant-ailments
#7
Samidurai Jayakumar, Selvarasu Sathiskumar, Nagarajan Baskaran, Radjasegarin Arumugam, Varadhrajan Vanitha
ETHENOPHARMACOLOGICAL RELEVANCE: India has a long tradition of practicing Ayurvedic medicine not only for human ailments, but also for the management of livestock in the form of ethno-veterinary practices. Asian elephant is a significant part of Indian culture, and ethno-veterinary practices have extended to manage and cure various ailments of Asian elephant in captivity. Much of this knowledge has been lost in the light of modern practices. AIM OF THE STUDY: This study is aimed at documenting the existing knowledge on ethno-veterinary medicines practiced by elephant keepers (mahouts) in Tamil Nadu and Puducherry...
February 26, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28224643/endophytic-phomopsis-sp-colonization-in-oryza-sativa-was-found-to-result-in-plant-growth-promotion-and-piperine-production
#8
Chithra S, Jasim B, Jyothis Mathew, Radhakrishnan E K
Endophytic fungi have been reported to have the acquired ability to synthesize host plant specific medicinal natural products. Many fungi with such properties have been characterized and optimized for the conditions which favor maximal production of desired products. However, the inherent plant colonization property of promising endophytic fungi is least studied. Exploiting the transgenome functioning of these fungi have immense applications to add beneficial features to non-host plants. In the present study, endophytic fungus Phomopsis sp...
February 22, 2017: Physiologia Plantarum
https://www.readbyqxmd.com/read/28185326/alkaloids-from-piper-nigrum-exhibit-antiinflammatory-activity-via-activating-the-nrf2-ho-1-pathway
#9
Quynh Mai Thi Ngo, Phuong Thao Tran, Manh Hung Tran, Jeong Ah Kim, Seong Soo Rho, Chi-Hwan Lim, Jin-Cheol Kim, Mi Hee Woo, Jae Sui Choi, Jeong-Hyung Lee, Byung Sun Min
In the present study, ten alkaloids, namely chabamide (1), pellitorine (2), retrofractamide A (3), pyrroperine (4), isopiperolein B (5), piperamide C9:1 (8E) (6), 6,7-dehydrobrachyamide B (7), 4,5-dihydropiperine (8), dehydropipernonaline (9), and piperine (10), were isolated from the fruits of Piper nigrum. Among these, chabamide (1), pellitorine (2), retrofractamide A (3), isopiperolein B (5), and 6,7-dehydrobrachyamide B (7) exhibited significant inhibitory activity on lipopolysaccharide-induced nitric oxide (NO) production in RAW264...
February 10, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28145468/the-srnaome-mining-revealed-existence-of-unique-signature-small-rnas-derived-from-5-8srrna-from-piper-nigrum-and-other-plant-lineages
#10
Srinivasan Asha, E V Soniya
Small RNAs derived from ribosomal RNAs (srRNAs) are rarely explored in the high-throughput data of plant systems. Here, we analyzed srRNAs from the deep-sequenced small RNA libraries of Piper nigrum, a unique magnoliid plant. The 5' end of the putative long form of 5.8S rRNA (5.8SLrRNA) was identified as the site for biogenesis of highly abundant srRNAs that are unique among the Piperaceae family of plants. A subsequent comparative analysis of the ninety-seven sRNAomes of diverse plants successfully uncovered the abundant existence and precise cleavage of unique rRF signature small RNAs upstream of a novel 5' consensus sequence of the 5...
February 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28137670/effects-of-thai-piperaceae-plant-extracts-on-neospora-caninum-infection
#11
Arpron Leesombun, Sookruetai Boonmasawai, Yoshifumi Nishikawa
Neosporosis has a worldwide distribution and causes economic losses in farming, particularly by increasing the risk of abortion in cattle. This study investigated the effects of Thai piperaceae (Piper betle, P. nigrum, and P. sarmentosum) extracts on Neospora caninum infections in vitro and in vivo. In an in vitro parasite growth assay based on the green fluorescent protein (GFP) signal, P. betle was the most effective extract at inhibiting parasite growth in human foreskin fibroblast cells (IC50 of GFP-expressing N...
January 27, 2017: Parasitology International
https://www.readbyqxmd.com/read/28110253/synthesis-of-silver-nanoparticles-ag-nps-for-anticancer-activities-mcf-7-breast-and-a549-lung-cell-lines-of-the-crude-extract-of-syzygium-aromaticum
#12
K Venugopal, H A Rather, K Rajagopal, M P Shanthi, K Sheriff, M Illiyas, R A Rather, E Manikandan, S Uvarajan, M Bhaskar, M Maaza
In the present report, silver nanoparticles were synthesized using Piper nigrum extract for in vitro cytotoxicity efficacy against MCF-7 and HEP-2 cells. The silver nanoparticles (AgNPs) were formed within 20min and after preliminarily confirmation by UV-Visible spectroscopy (strong peak observed at ~441nm), they were characterized by using FT-IR and HR-TEM. The TEM images show spherical shape of biosynthesized AgNPs with particle size in the range 5-40nm while as compositional analysis were observed by EDAX...
December 20, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28017696/ethnobiological-treatments-of-neurological-conditions-in-the-chota-nagpur-plateau-india
#13
Abhijit Dey, Partha Gorai, Anuradha Mukherjee, Raghunath Dhan, Biplob Kumar Modak
ETHNOPHARMACOLOGICAL RELEVANCE: World Health Organization (WHO) has recognized the contribution of traditional medicine in the primary health care system. WHO also considers neurological disorders as one of the prime concern to the public health. Inadequate and inaccessible health facilities in the rural and underprivileged areas have forced the various tribal and non-tribal communities to use ethno-phyto and ethno-zoo therapeutics against different ailments. Chota Nagpur Plateau, India is one of the richest in India in terms of plant and animal diversity, and houses a number of indigenous communities often practising their own ethnobiological medicines...
December 22, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28001214/a-biodegradable-device-for-the-controlled-release-of-piper-nigrum-piperaceae-standardized-extract-to-control-aedes-aegypti-diptera-culicidae-larvae
#14
Kauê Muller Custódio, Joice Guilherme de Oliveira, Diego Moterle, Karine Modolon Zepon, Josiane Somariva Prophiro, Luiz Alberto Kanis
INTRODUCTION: The significant increase in dengue, Zika, and chikungunya and the resistance of the Aedes aegypti mosquito to major insecticides emphasize the importance of studying alternatives to control this vector. The aim of this study was to develop a controlled-release device containing Piper nigrum extract and to study its larvicidal activity against Aedes aegypti. METHODS: Piper nigrum extract was produced by maceration, standardized in piperine, and incorporated into cotton threads, which were inserted into hydrogel cylinders manufactured by the extrusion of carrageenan and carob...
November 2016: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/27987881/development-of-chitosan-based-gold-nanomaterial-as-an-efficient-antifilarial-agent-a-mechanistic-approach
#15
Swadhin K Saha, Priya Roy, Maloy K Mondal, Debiprasad Roy, Prajna Gayen, Pranesh Chowdhury, Santi P Sinha Babu
The gold nanoparticles (AuNPs) have been synthesized biogenically by using black pepper (Piper nigrum) extract according to the principles of green chemistry in presence and absence of a biopolymer, chitosan. A comprehensive study (up to cellular level) on the antifilarial (against Setaria cervi) activity of AuNPs has been made for the first time with a view to use it clinically. The bioactivity of biopolymer capped biogenic AuNP increases significantly compared to simple biogenic AuNP. The biopolymer plays an important role in inspiring AuNP through its inherent positive charges and hydrophobicity...
February 10, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27960631/exploring-the-binding-mechanism-and-kinetics-of-piperine-with-snake-venom-secretory-phospholipase-a2
#16
A Christian Bharathi, Sistla Srinivas, B Syed Ibrahim
Secreted venom Phospholipase A2 is highly responsible for pharmacological effects like neurotoxicity, myotoxicity, hemolytic, anti-coagulation, and platelet aggregation. Neutralization of these pharmacological behaviors is one of the challenges existing for many decades and a potent drug compound for this is very much needed to control local effects of venom sPLA2. In this study, we investigated binding mechanism and kinetics of inhibition of Piperine (major constitute of Piper nigrum) with sPLA2 using DFT, MD simulation, MM-PBSA, and SPR method...
January 6, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/27924129/interplay-of-genes-in-plant-pathogen-interactions-in-planta-expression-and-docking-studies-of-a-beta-1-3-glucanase-gene-from-piper-colubrinum-and-a-glucanase-inhibitor-gene-from-phytophthora-capsici
#17
K Johnson George, O Rosana Babu, I P Vijesh Kumar, J Santhosh Eapen, M Anandaraj
Oomycete pathogen, Phytophthora capsici is devastating for black pepper (Piper nigrum L.) and causes foot rot disease at all stages of plant growth. Phytophthora secretes a glucanase inhibitor protein (GIP), which is capable of inhibiting defence proteins like endoglucanases. In this particular study Quantitative PCR analysis, molecular docking studies and analysis of sequences of Glucanase inhibitor protein and beta-1,3 glucanse genes were done mainly depending on the data derived from Phytophthora capsici whole genome sequencing and Piper colubrinum RNA-sequencing (RNA-Seq)...
October 2016: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/27915029/cytotoxicity-study-of-piper-nigrum-seed-mediated-synthesized-sno2-nanoparticles-towards-colorectal-hct116-and-lung-cancer-a549-cell-lines
#18
Sai Kumar Tammina, Badal Kumar Mandal, Shivendu Ranjan, Nandita Dasgupta
Different sized tetragonal tin oxide nanoparticles (SnO2 NPs) were synthesized using Piper nigrum seed extract at three different calcination temperatures (300, 500, 900°C) and these nanoparticles (NPs) were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), dynamic light scattering (DLS) and Fourier transform infrared spectrophotometry (FT-IR). The optical properties were studied using UV-Vis and photoluminescence (PL) spectrophotometers. The generation of reactive oxygen species (ROS) was monitored by using a fluorescence spectrophotometer and fluorescence microscope...
January 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/27875748/piperine-attenuates-lipopolysaccharide-lps-induced-inflammatory-responses-in-bv2-microglia
#19
Chen Wang-Sheng, An Jie, Li Jian-Jun, Hong Lan, Xing Zeng-Bao, Li Chang-Qing
Piperine, the chief alkaloid isolated from Piper nigrum, has been known to have anti-inflammatory effect. However, the effects of piperine on neuroinflammation have not been reported. In the present study, we evaluated the effects of piperine on neuroinflammation in BV2 microglia and investigated the molecular mechanism. The results showed that piperine significantly inhibited LPS-induced TNF-α, IL-6, IL-1β, and PGE2 production in BV2 cells. Western blot analysis showed that piperine dose-dependently inhibited LPS-induced NF-κB activation...
January 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/27862930/piperine-inhibits-abca1-degradation-and-promotes-cholesterol-efflux-from-thp-1-derived-macrophages
#20
Limei Wang, Veronika Palme, Susanne Rotter, Nicole Schilcher, Malsor Cukaj, Dongdong Wang, Angela Ladurner, Elke H Heiss, Herbert Stangl, Verena M Dirsch, Atanas G Atanasov
SCOPE: Increased macrophage cholesterol efflux (ChE) is considered to have anti-atherosclerotic effect counteracting cardiovascular disease. The principle pungent ingredient of the fruits of Piper nigrum, piperine, is identified in this study as a ChE inducer in THP-1-derived macrophages, and mechanisms underlying this effect are explored. METHODS AND RESULTS: Without affecting cell viability, piperine concentration-dependently enhances ChE in THP-1-derived macrophages from 25 to 100 μM...
November 15, 2016: Molecular Nutrition & Food Research
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