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Amelanotic melanoma

Sang Yub Kim, Sook Jung Yun
Malignant melanoma is a rare disease in Asians but potentially the most aggressive form of skin cancer worldwide. It can occur in any melanocyte-containing anatomic site. Four main cutaneous melanoma subtypes are recognized: lentigo maligna melanoma, superficial spreading melanoma, acral lentiginous melanoma (ALM), and nodular melanoma. Generally, excessive exposure to ultraviolet (UV) radiation increases the risk of melanoma. The exception is ALM, which is the most common melanoma subtype in Asians and is not associated with UV radiation...
September 2016: Chonnam Medical Journal
Sheikh Asad, Idrees Sher, Jens Peters-Willke, Peter Jessup
Neurotropic melanoma (NM) is a rare variant of cutaneous melanomas. Compared with conventional melanoma, NM is more locally aggressive with an increased tendency for local recurrence but less likely for nodal or distant metastases. The often amelanotic, benign appearance may lead to treatment issues such as late presentation, diagnostic delay, misdiagnosis, insufficient surgical margins, and recurrence with resulting poor outcome. To our knowledge, this is the first case report of NM with contiguous spread to the spinal cord...
March 2016: J Spine Surg
Vitorino Modesto Dos Santos, Manoel da Costa Gondim Neto, Tereza Rodrigues de Carvalho Vieira de Melo, Iara Machado Motta
A 60-year Brazilian woman, presented with an enlarged lymph node in the neck for one year, and a superficial nonulcerated lesion was observed in the scalp. Fine needle aspiration and biopsy of the lymph node revealed amelanocytic metastasis, and immunohistochemistry study showed Melan-A/ Mart-1 antigen (clone A103 and S-100 protein). The entire suspected area of the scalp was further resected and an amelanotic melanoma without angiolymphatic invasion was diagnosed. Ultrasonography and PET-computed tomography showed hypermetabolic cystic area in the right parotid...
September 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
S Ajamil Rodanés, C García-Álvarez, M A Saornil Álvarez
No abstract text is available yet for this article.
September 21, 2016: Archivos de la Sociedad Española de Oftalmología
J Łudzik, A M Witkowski, I Roterman-Konieczna, S Bassoli, F Farnetani, G Pellacani
BACKGROUND: Solitary pink lesions in differential diagnosis with hypopigmented/amelanotic melanoma present a diagnostic challenge in daily practice and are regularly referred for second expert opinion. Reflectance confocal microscopy (RCM) has been shown to improve diagnostic accuracy of dermoscopically equivocal pink lesions. No studies have been performed to evaluate the effect of adding a second expert reader and automatic removal of lesions with discordant management recommendations and its potential effect on diagnostic sensitivity and final management of these lesions in retrospective or telemedicine settings...
2016: PloS One
Tomoharu Taga, Taichiro Nonaka, Toshiaki Manabe, Kazuhisa Bessho
Polypoid malignant melanoma of the oral cavity is extremely rare. This report describes the case of the 3-time occurrence of a polypoid malignant melanoma of the maxillary gingiva in an 84-year-old woman who had removed the primary tumor by herself. The second polypoid malignant melanoma was a black 7-cm pedunculated mass surrounded by pigmented mucosa. Histologically, the tumor exhibited an ulcerated surface lined by squamous cells and contained polygonal cells with brown-and-black pigmentation. The third polypoid malignant melanoma was observed at the same location 7 months after surgery; it was a black hemorrhagic mass approximately 1...
July 30, 2016: Journal of Oral and Maxillofacial Surgery
Audrey Detrixhe, Florence Libon, Marion Mansuy, Nazli Nikkels-Tassoudji, Andrée Rorive, Jorge E Arrese, Pascale Quatresooz, Marie-Annick Reginster, Arjen F Nikkels
Increased awareness among dermatologists as well as the development of dermoscopy and sequential dermoscopy have contributed significantly toward an increase in the diagnostic accuracy of pigmented melanoma and even of amelanotic melanoma. However, the dermatologist's nightmare is the small group of melanomas that present as common skin diseases, often associated with a significant delay in diagnosis and hence a poor prognosis. The study was carried out to prospectively assess the number of melanomas lacking any clinical suspicion of melanoma and to describe their clinical and histological features over a 6-year observation period in an University Tertiary Skin Cancer Center...
August 17, 2016: Melanoma Research
Nicola di Meo, Giuseppe Stinco, Alessandro Gatti, Mattia Fadel, Silvia Vichi, Giusto Trevisan
Dear Editor, Apocrine hidradenoma is a rare benign adnexal tumor related to the more common poroma, as they both originate from sweat glands. Hidradenoma usually has an eccrine differentiation, but an apocrine differentiation is possible. Due to its rarity and non-specific clinical appearance it is difficult to differentiate it from other malignant cutaneous lesions. In this challenging task, dermatoscopy could be particularly helpful to better describe, recognize, and differentiate these lesions. Unfortunately, the literature offers only few dermatoscopic descriptions of this rare cutaneous neoplasm...
June 2016: Acta Dermatovenerologica Croatica: ADC
Chih-Chao Chang, Chih-Hsien Chang, Yi-Hsuan Lo, Ming-Hsien Lin, Chih-Chieh Shen, Ren-Shyan Liu, Hsin-Ell Wang, Chuan-Lin Chen
Melanin is an attractive target for the diagnosis and treatment of malignant melanoma. Previous studies have demonstrated the specific binding ability of benzamide moiety to melanin. In this study, we developed a novel (18)F-labeled NOTA-benzamide conjugate, Al(18)F-NOTA-BZA, which can be synthesized in 30min with a radiochemical yield of 20-35% and a radiochemical purity of >95%. Al(18)F-NOTA-BZA is highly hydrophilic (logP=-1.96) and shows good in vitro stability. Intravenous administration of Al(18)F-NOTA-BZA in two melanoma-bearing mouse models revealed highly specific uptake in B16F0 melanotic melanoma (6...
August 15, 2016: Bioorganic & Medicinal Chemistry Letters
T R Glowka, M D Keyver-Paik, T Thiesler, J Landsberg, J C Kalff, D Pantelis
BACKGROUND: Anorectal malignant melanoma is a rare tumor with a poor prognosis. Typical symptoms (bleeding, pain, perianal mass) are characteristic of hemorrhoids. This, together with the high rate of amelanotic tumors, often delays diagnosis. No therapy guidelines exist. MATERIALS AND METHODS: Based on our own experience of surgically treated patients and an extensive literature search, we present a stage-dependent therapeutic concept. RESULTS: Eight patients (six women) with a mean age of 65 ± 8 years were treated at our institution...
September 2016: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
Domenico Ferraioli, Gery Lamblin, Patrice Mathevet, Jessika Hetu, Isabelle Berakdar, Frederic Beurrier, Nicolas Chopin
PURPOSE: Genital melanoma is a rare pathology. We present the experience of two comprehensive cancer centers in Lyon (France) in the management of genital melanoma in order to identify prognostic factors and optimal treatments. METHODS: Between April 1992 and Mars 2014, 16 patients with a primary genital melanoma were referred to our department. Nine patients presented a vaginal melanoma, six vulvar melanomas and only one cervical melanoma. The median dimension of the lesion was 33...
June 30, 2016: Archives of Gynecology and Obstetrics
Yves Réguerre, Marie Vittaz, Daniel Orbach, Caroline Robert, Christine Bodemer, Christina Mateus, Dominique Plantaz, Emmanuel Plouvier, Patrick Lutz, Josue Rakotonjanahary, Sylvie Fraitag, Ludovic Martin
OBJECTIVES: Recent progress in the understanding of tumor biology and new targeted therapies has led to improved survival in adults with malignant melanoma (MM). MM is rare in children, especially before puberty. We report here our experience with pediatric patients with MM, describe the clinical presentation, treatment and evolution, and compare prepubescent and postpubescent disease. METHODS: A retrospective, descriptive, national multicenter study was undertaken of 52 cases of MM in children and adolescents...
November 2016: Pediatric Blood & Cancer
Austen N Knapp, Wasim A Samara, Carol L Shields, Jerry A Shields, Ralph C Eagle
An 8-year-old healthy boy underwent surgery for excision of a painless, enlarging vascularized conjunctival tumor. Histopathology disclosed a mass comprised of interweaving spindle cells and scattered histiocytes in a fibrous matrix, consistent with benign fibrous histiocytoma. This rare tumor can resemble several conditions, including scleritis/episcleritis, inflamed pterygium, juvenile xanthogranuloma, foreign body granuloma, solitary fibrous tumor, amelanotic melanoma, and squamous cell carcinoma.
August 2016: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Emily M Erstine, Hillary R Elwood, Kent C Westbrook, Timothy H McCalmont, Sara C Shalin, Jerad M Gardner
Desmoplastic melanoma is an uncommon form of melanoma characterized by atypical spindled melanocytes and abundant collagen deposition. It typically presents in sun-damaged skin of the elderly as an amelanotic, indurated lesion. It has a higher tendency for local recurrence but lower risk of lymph node metastasis vs. conventional malignant melanoma. We report two cases in women aged 59 and 66 who presented with small scalp lesions clinically suggestive of alopecia. The differential diagnosis included alopecia areata, lupus erythematosus and lichen planopilaris...
October 2016: Journal of Cutaneous Pathology
Hassan A Aziz, Yasha S Modi, Thomas P Plesec, Arun D Singh
PURPOSE: To report a case of an amelanotic irido-ciliary ring melanoma. DESIGN: Interventional case report. RESULTS: A 44-year-old male was followed for asymptomatic amelanotic iris nevus of the right eye that was noted to have a localized ciliary body mass with ring extension along the trabecular meshwork. Fine needle aspiration biopsy was consistent with malignant melanoma. The patient underwent enucleation and remains disease free at 9 years of follow-up...
April 2016: Ocular Oncology and Pathology
Candelaria Bracalente, Irene L Ibañez, Ariel Berenstein, Cintia Notcovich, María B Cerda, Fabio Klamt, Ariel Chernomoretz, Hebe Durán
Reactive oxygen species (ROS) are implicated in tumor transformation. The antioxidant system (AOS) protects cells from ROS damage. However, it is also hijacked by cancers cells to proliferate within the tumor. Thus, identifying proteins altered by redox imbalance in cancer cells is an attractive prognostic and therapeutic tool. Gene expression microarrays in A375 melanoma cells with different ROS levels after overexpressing catalase were performed. Dissimilar phenotypes by differential compensation to hydrogen peroxide scavenging were generated...
May 10, 2016: Oncotarget
Candelaria Bracalente, Noelia Salguero, Cintia Notcovich, Carolina B Müller, Leonardo L da Motta, Fabio Klamt, Irene L Ibañez, Hebe Durán
Advanced melanoma is the most aggressive form of skin cancer. It is highly metastatic and dysfunctional in melanogenesis; two processes that are induced by H2O2. This work presents a melanoma cell model with low levels of H2O2 induced by catalase overexpression to study differentiation/dedifferentiation processes. Three clones (A7, C10 and G10) of human A375 amelanotic melanoma cells with quite distinct phenotypes were obtained. These clones faced H2O2 scavenging by two main strategies. One developed by clone G10 where ROS increased...
May 7, 2016: Oncotarget
P Guitera, S W Menzies, G Argenziano, C Longo, A Losi, M Drummond, R A Scolyer, G Pellacani
BACKGOUND: Amelanotic melanomas are often difficult to diagnose. OBJECTIVES: Find and test best diagnosis methods with dermoscopy and reflectance confocal microscopy (RCM) tools. METHODS: We selected consecutive, difficult-to-diagnose, light-colored and amelanotic skin lesions from three centers (in Australia and Italy). Dermoscopy and RCM diagnostic utility were evaluated under blinded conditions utilizing 45 melanomas (16 in situ, 29 invasive), 68 nevi, 48 BCC, 10 AK, 10 SCC and 13 other benign lesions...
May 13, 2016: British Journal of Dermatology
Katharine S Sears, Ian G Rennie, Hardeep Singh Mudhar
PURPOSE: To describe the clinical and histopathological features of a 61-year-old male with a history of eczema, asthma and schizophrenia on long-term chlorpromazine medication, who developed a unilateral limbal tumour in association with bilateral melanosis. PROCEDURES: The patient was referred for a routine cataract assessment, and an incidental pink gelatinous limbal lesion was detected on the left side, associated with bilateral speckled brown conjunctival pigmentation...
June 2015: Ocular Oncology and Pathology
Manuela Hirz, Christiane Herden
The diagnosis of malignant melanoma can be difficult because these tumors can be amelanotic and may contain diverse variants and divergent differentiations, of which the signet-ring cell subtype is very rare and has only been described in humans, dogs, cats, and a hamster. We describe herein histopathologic and immunohistochemical approaches taken to diagnose a case of signet-ring cell malignant melanoma with myofibroblastic differentiation in a cat. A tumor within the abdominal skin of a 2-year-old cat was composed of signet-ring cells and irregularly interwoven streams of spindle cells...
July 2016: Journal of Veterinary Diagnostic Investigation
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