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Amelanotic melanoma

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https://www.readbyqxmd.com/read/29772919/erythema-nodosum-as-the-initial-presentation-of-nivolumab-induced-sarcoidosis-like-reaction
#1
Alexandre Laroche, Evelyn Alarcon Chinchilla, Emilie Bourgeault, Marc-André Doré
BACKGROUND: We report a case of nivolumab-related sarcoidosis-like syndrome that initially presented with erythema nodosum. Sarcoidosis development has been described in single and combination immunotherapy. CASE PRESENTATION: A 68-year-old white woman with metastatic ocular amelanotic choroid melanoma was treated with nivolumab. The patient developed histologically confirmed erythema nodosum lesions and pulmonary granuloma sarcoidosis. Nivolumab was discontinued and the patient started ipilimumab therapy...
May 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29759015/morphologic-and-immunohistochemical-characteristics-of-anorectal-melanoma
#2
Ahmad Charifa, Xuchen Zhang
Anorectal melanoma is a rare aggressive disease. Due to its rarity and considerable histologic and immunohistochemical variabilities, misdiagnosis as lymphoma, carcinoma, sarcoma, and/or gastrointestinal stromal tumor is not uncommon, particularly in amelanotic cases. We reviewed histologic features and immunohistochemical stains of 19 anorectal melanoma cases. Histopathologic features were evaluated including junctional activity, melanin pigment, and morphologic features. Immunohistochemical stains were performed using Sox10, S100 protein, HMB-45, melan-A, CD56, and cytokeratins...
May 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29755903/subungual-amelanotic-melanoma-masquerading-as-onychomycosis
#3
Ryan R Riahi, Philip R Cohen, Leonard H Goldberg
Subungual amelanotic melanoma is rare. In addition, amelanotic melanoma can mimic non-melanocytic tumors. A 67-year-old woman had a four-year history of dystrophy of the left fourth fingernail. Periodic acid-Schiff staining of the nail plate demonstrated fungal hyphae, establishing a diagnosis of tinea unguium. The nail plate subsequently detached and the underlying nail bed showed a red, friable mass that was biopsied and confirmed a diagnosis of melanoma. In conclusion, additional morphologic change of a persistent nail dystrophy-even with a biopsy-confirmed diagnosis of onychomycosis-may require consideration for repeat evaluation, including a biopsy, to exclude the possibility of a subungual malignant tumor...
March 11, 2018: Curēus
https://www.readbyqxmd.com/read/29750750/malignant-melanoma-clinically-mimicking-pyogenic-granuloma-comparison-of-clinical-evaluation-and-histopathology
#4
Michael Moshe, Assi Levi, Dean Ad-El, Dan Ben-Amitai, Daniel Mimouni, Elena Didkovsky, Meora Feinmesser, Moshe Lapidoth
Amelanotic melanomas (AMMs) account for a small proportion of all melanomas. They pose a risk of delayed diagnosis and, consequently, poor prognosis. AMMs may atypically present as a pyogenic granuloma-like lesion. This study sought to investigate the prevalence and clinical and histological features of AMM masquerading as pyogenic granuloma. The database of a tertiary medical center was screened for all patients pathologically diagnosed with melanoma in 2005-2016. Those with a suspected primary (i.e. pre-excision) clinical diagnosis of pyogenic granuloma were identified, and their demographic, clinical, histologic, and outcome data were collected from the medical files...
May 10, 2018: Melanoma Research
https://www.readbyqxmd.com/read/29738013/atypical-posterior-scleritis-mimicking-choroidal-melanoma
#5
Heba M Alsharif, Saad A Al-Dahmash
We report a case of atypical posterior scleritis mimicking amelanotic choroidal melanoma. A 30-year-old healthy Filipino man, with a history of painless subacute loss of vision in his left eye over 5 months, was referred to our institute for further workup and management. On examination, visual acuity of the left eye was 20/200. Anterior segment examination yielded unremarkable results, with injected conjunctiva and quiet episcleral blood vessels, while fundus examination revealed non-pigmented nasal choroidal mass, with significant subretinal fluid resembling amelanotic choroidal melanoma...
May 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29718821/synergism-of-therapies-after-postoperative-autograft-failure-in-a-patient-with-melanoma-of-the-foot-misdiagnosed-as-a-pressure-ulcer
#6
Agata Janowska, Teresa Oranges, Andrea Chiricozzi, Marco Romanelli, Valentina Dini
INTRODUCTION: Amelanotic melanoma of the foot is a diagnostic challenge for physicians as it often appears as a benign lesion. In order to make the correct diagnosis at early stages, it is recommended to perform a biopsy of worsening lesions that are refractory to standard treatments, particularly nonhealing wounds. CASE REPORT: The authors describe the case of a 57-year-old man with amelanotic melanoma of the foot that had been treated as a pressure ulcer for 3 months...
April 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29663723/intraocular-metastasis-of-medullary-thyroid-carcinoma-investigated-by-transscleral-fine-needle-aspiration-a-case-report-and-review-of-the-literature
#7
Małgorzata Gajdzis, Nathalie Cassoux, Maria Lesnik, Caroline Hoffmann, Nathalie Badois, Paweł Gajdzis, Jerzy Klijanienko
Medullary thyroid carcinoma occurs in a sporadic setting and may also be inherited in an autosomal dominant fashion, which is related with germline mutations of the RET gene. Metastases are often present at the time of a diagnosis-most frequently within the cervical lymph nodes, followed by the liver, lungs, and bones. Intraocular metastases are extremely rare. We present a case of choroidal metastasis as a first presentation of disease progression in a patient with Multiple Endocrine Neoplasia type 2A syndrome (MEN2A) who had undergone thyroidectomy 33 years earlier for medullary thyroid carcinoma...
April 16, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29659412/photodynamic-therapy-as-primary-treatment-for-small-choroidal-melanoma
#8
Elif B Turkoglu, Renelle Pointdujour-Lim, Arman Mashayekhi, Carol L Shields
PURPOSE: To report outcomes of photodynamic therapy (PDT) as primary treatment for small amelanotic choroidal melanoma. METHODS: Retrospective interventional case series of 12 patients with small choroidal melanoma treated with standard-fluence PDT (83 seconds; 50 J/cm) using verteporfin. OUTCOME MEASURES: Tumor regression, subretinal fluid resolution, best-corrected visual acuity, and PDT complications. RESULTS: There were 12 eyes with melanoma, demonstrating amelanotic (10 [83%]) or lightly pigmented (n = 2, 17%) appearance...
April 13, 2018: Retina
https://www.readbyqxmd.com/read/29602781/amelanotic-melanoma-a-unique-case-study-and-review-of-the-literature
#9
Katherine A Kaizer-Salk, Robert J Herten, Bruce D Ragsdale, Roberta D Sengelmann
Amelanotic melanoma (AM) is a rare form of melanoma which lacks visible pigment. Due to the achromic manifestation of this atypical cutaneous malignancy, it has been difficult to establish clinical criteria for diagnosis. Thus, AM often progresses into an invasive disease due to delayed diagnosis. In this report, we describe the case of a 72-year-old Caucasian woman who had been diagnosed with AM after 3 years of failed treatments for what presented as a periorbital dermatitis. Her Clark's level 4, 1.30 mm thick melanoma required nine surgeries for successful resection and reconstruction...
March 29, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29569417/dermoscopy-features-of-atypical-fibroxanthoma-a-multicenter-study-of-the-international-dermoscopy-society
#10
Elvira Moscarella, Simonetta Piana, Francesca Specchio, Athanassios Kyrgidis, Gianluca Nazzaro, Maite L Eliceche, Francesco Savoia, Leonardo Bugatti, Giorgio Filosa, Iris Zalaudek, Federica Scarfi, Mike Inskip, Cliff Rosendahl, John H Pyne, Graeme Siggs, Arzu K Toğral, Horatio Cabo, Lubomir Drlik, Aimilios Lallas, Caterina Longo, Giuseppe Argenziano
BACKGROUND/OBJECTIVES: Little is known about the dermoscopic features of atypical fibroxanthoma. METHODS: This was a case-control study. Atypical fibroxanthoma lesions were compared with a control group with non-melanoma skin cancer. RESULTS: Altogether 40 atypical fibroxanthoma were collected. Most developed in men (93%), appearing mainly as nodular (63%), amelanotic (93%) and ulcerated (78%) lesions. Most lesions were located on the scalp (55%) and the ears (13%)...
March 23, 2018: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/29569229/diagnostic-accuracy-of-dermatofluoroscopy-in-cutaneous-melanoma-detection-results-of-a-prospective-multicentre-clinical-study-in-476-pigmented-lesions
#11
A Forschner, U Keim, M Hofmann, I Spänkuch, D Lomberg, B Weide, I Tampouri, T Eigentler, C Fink, C Garbe, H A Haenssle
BACKGROUND: Early detection is a key factor in improving survival from melanoma. Today, the clinical diagnosis of cutaneous melanoma is mostly based on visual inspection and dermoscopy. Preclinical studies in freshly excised or paraffin-embedded tissue have shown that the melanin fluorescence spectra after stepwise two-photon excitation, a process termed dermatofluoroscopy, differ between cutaneous melanoma and melanocytic nevi. However, confirmation from a larger prospective clinical study is lacking...
March 22, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29565434/enhanced-targeting-of-triple-negative-breast-carcinoma-and-malignant-melanoma-by-photochemical-internalization-of-cspg4-targeting-immunotoxins
#12
M S Eng, J Kaur, L Prasmickaite, B Ø Engesæter, A Weyergang, E Skarpen, K Berg, M G Rosenblum, G M Mælandsmo, A Høgset, S Ferrone, P K Selbo
Triple-negative breast cancer (TNBC) and malignant melanoma are highly aggressive cancers that widely express the cell surface chondroitin sulfate proteoglycan 4 (CSPG4/NG2). CSPG4 plays an important role in tumor cell growth and survival and promotes chemo- and radiotherapy resistance, suggesting that CSPG4 is an attractive target in cancer therapy. In the present work, we applied the drug delivery technology photochemical internalization (PCI) in combination with the novel CSPG4-targeting immunotoxin 225...
March 22, 2018: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/29545447/amelanotic-melanoma
#13
Andy J Muinonen-Martin, Sally Jane O'Shea, Julia Newton-Bishop
No abstract text is available yet for this article.
March 15, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29483981/subungual-exostosis-in-a-young-soccer-player
#14
Georgi Tchernev, Yavor Grigorov, Stanislav Philipov, Anastasiya Chokoeva, Uwe Wollina, Torello Lotti, Jose Cardoso, Irina Yungareva, Ilia Lozev, Georgi Konstantinov Maximov
BACKGROUND: Subungual exostosis is a relatively uncommon, benign osteocartilaginous tumor of the distal phalanx of the toes or fingers in young adults, considered as a rare variant of osteochondroma. Differential diagnoses include subungual verruca (viral wart), pyogenic granuloma, osteochondroma, amelanotic subungual melanoma and glomus tumour. Misdiagnosis and total onychodystrophy frequently occur as a result of late treatment or inadequate treatment strategy. Dermoscopy could be a useful technique, involved in the diagnostic process, although X-ray examination and histopathology are mandatory for the diagnosis...
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29450912/association-of-clinicopathological-features-of-melanoma-with-total-naevus-count-and-a-history-of-dysplastic-naevi-a-cross-sectional-retrospective-study-within-an-academic-centre
#15
S Y Tan, L C Strazzulla, X Li, J J Park, S J Lee, C C Kim
BACKGROUND: High naevus count (HNC) (≥ 50 naevi) and presence of dysplastic naevi (DN) are risk factors for malignant melanoma (MM); however, MMs also occur in patients with low naevus count (LNC) (< 50 naevi) and in patients without DN. Little is known about differences between MMs in these groups. AIM: To characterize the clinicopathological differences between MMs in patients with HNC and those in patients with LNC, with or without biopsy-proven DN. METHODS: This was a cross-sectional retrospective chart review of 281 patients with MM seen between April 2013 and March 2014 at an academic pigmented lesion clinic (Boston, MA, USA)...
February 16, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29350666/melanoma-in-situ-mimicking-a-lichen-planus-like-keratosis
#16
Andrea Sisti, Amgiad Fallaha, Juri Tassinari, Giuseppe Nisi, Luca Grimaldi, Klaus Eisendle
The incidence of melanoma has steadily increased over the past three decades. Melanoma in situ (MIS),  defined as melanoma that is limited to the epidermis, contributes to a disproportionately high percentage of this rising incidence. Amelanotic melanoma presents as an erythematous macule or plaque and may initially be misdiagnosed as an inflammatory disorder. We report a case of amelonatic MIS raised on non-sun-exposed skin, inducing a lichen planus-like keratosis as inflammatory reaction, which clinically masked the melanoma...
January 16, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29314288/the-limitations-of-dermoscopy-false-positive-and-false-negative-tumours
#17
REVIEW
V Papageorgiou, Z Apalla, E Sotiriou, C Papageorgiou, E Lazaridou, S Vakirlis, D Ioannides, A Lallas
Dermoscopy has been documented to increase the diagnostic accuracy of clinicians evaluating skin tumours, improving their ability to detect skin cancer and better recognize benign moles. However, dermoscopically 'false-positive' and 'false-negative' tumours do exist. False-positive diagnosis usually leads to unnecessary excisions. False-negative diagnosis is much more dangerous, as it might result in overlooking a cancer, with severe undesirable consequences for the patient and the physician. Therefore, management strategies should mainly focus on addressing the risk of dermoscopically false-negative tumours...
January 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29250583/slow-growing-amelanotic-malignant-melanoma-of-the-esophagus-with-long-survival-a-case-report-and-review-of-the-literature
#18
Yutaka Hirayama, Tajika Masahiro, Tsutomu Tanaka, Makoto Ishihara, Sachiyo Ohnishi, Kazuo Hara, Nobumasa Mizuno, Susumu Hijioka, Nozomi Okuno, Tetsuya Abe, Norihisa Uemura, Jiro Kawakami, Shintarou Kurahashi, Yasuhiro Shimizu, Yasushi Yatabe, Yasumasa Niwa
Background and study aims  We report a case of amelanotic malignant melanoma of the esophagus (AMME), an exceedingly rare disease. A 77-year-old Japanese woman presented to our hospital with features suggestive of a middle esophageal submucosal tumor, which was diagnosed pathologically as AMME. The patient underwent thoracoscopic resection of the esophagus and laparoscopic gastric tube reconstruction. Three years after surgery, computed tomography showed no recurrence. Generally, the prognosis of malignant melanoma of the esophagus is very poor...
November 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29245305/a-melanotic-malignant-melanoma-presenting-as-a-keloid-a-case-report
#19
Jinjing Jia, Min Wang, Liumei Song, Yiguo Feng
RATIONALE: Amelanotic malignant melanoma (AMM) is a rare subtype of malignant melanoma (MM) that manifests atypically and is easily misdiagnosed or missed altogether. The keloid type of AMM has rarely been reported. Herein, we provide information to improve the clinical diagnosis of AMM types and raise awareness to ensure early diagnosis and timely treatment. PATIENT CONCERNS: A 20-year old woman presented with a mass on her left shoulder of 1 year's duration that had been treated surgically...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29238803/noninvasive-gene-expression-testing-in-amelanotic-melanoma
#20
Maria V Childs
No abstract text is available yet for this article.
February 1, 2018: JAMA Dermatology
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