keyword
https://read.qxmd.com/read/38511025/desmoplastic-melanoma-of-the-chest-wall-a-diagnostic-dilemma
#1
Adil Aziz Khan, Sufian Zaheer, Parth Gulati, Sana Ahuja
Desmoplastic melanoma is an extremely rare subtype of malignant melanoma comprising only 1% of all the cutaneous melanomas. Being amelanotic and owing to its histopathological features of spindle cells lying in a collagenized stroma, it is often misdiagnosed as a dermatofibroma or scar tissue. The present case study describes a case of desmoplastic melanoma of the chest wall where the final diagnosis could be arrived at only after an extensive immunohistochemical panel to exclude other spindle cell proliferations...
March 2024: Indian Journal of Surgical Oncology
https://read.qxmd.com/read/38483241/dermatoscopic-patterns-of-cutaneous-metastases-a-multicentre-cross-sectional-study-of-the-international-dermoscopy-society
#2
JOURNAL ARTICLE
Danica Tiodorovic, Jelena Stojkovic-Filipovic, Ashfaq Marghoob, Giuseppe Argenziano, Susana Puig, Josep Malvehy, Linda Tognetti, Rubegni Pietro, Bengu Nisa Akay, Iris Zalaudek, Holger A Haenssle, Christine Müller-Christmann, Elisa Cinotti, Jean Luc Perrot, Pedro Zaballos, Renato Marchiori Bakos, Luc Thomas, Ketty Peris, Aimilios Lallas, Zoe Apalla, Juergen F Kreusch, Isabelle Tromme, Alexandros J Stratigos, Maria Antonietta Pizzichetta, Lidija Kandolf, Caterina Longo, Andreas Blum, Masaru Tanaka, Rainer Hofmann-Wellenhof, Andrija Jovic, John Paoli, Marija Buljan, Martina Espasandín-Arias, Horacio Cabo, Sonia Rodrigiez Saa, Gabriel Salerni, Gianluca Nazzaro, Grazyna Kaminska-Winciorek, Giovanni Damiani, Franciska Geszti, Harald Kittler
BACKGROUND: The detection of cutaneous metastases (CMs) from various primary tumours represents a diagnostic challenge. OBJECTIVES: Our aim was to evaluate the general characteristics and dermatoscopic features of CMs from different primary tumours. METHODS: Retrospective, multicentre, descriptive, cross-sectional study of biopsy-proven CMs. RESULTS: We included 583 patients (247 females, median age: 64 years, 25%-75% percentiles: 54-74 years) with 632 CMs, of which 52...
March 14, 2024: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/38457580/conjunctival-myxoma-a-case-report-and-review-of-a-rare-tumor
#3
JOURNAL ARTICLE
Seong Eun Lee, Sung Bok Lee, Kyunghee Kim, Jae Yun Sung
RATIONALE: Conjunctival myxoma is a rare benign tumor, which can mimic more common conjunctival lesions such as a cyst, lymphangioma, amelanotic nevus, neurofibroma, amelanotic melanoma, or lipoma. We describe a patient with the conjunctival myxoma, who was initially misdiagnosed as a conjunctival cyst. This case report includes intraoperative photographs and various immunohistochemical staining images. PATIENTS CONCERNS: A 55-year-old woman presented with a painless mass in the superotemporal conjunctiva of the left eye, which she had noticed 1 month ago...
March 8, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38437817/is-primary-poorly-differentiated-sarcomatoid-malignancy-of-the-parotid-gland-sarcomatoid-undifferentiated-dedifferentiated-melanoma-report-of-three-unusual-cases-diagnosed-by-fine-needle-aspiration-combined-with-histological-immunohistochemical-and-molecular
#4
JOURNAL ARTICLE
Jerzy Klijanienko, Julien Masliah-Planchon, Olivier Choussy, Guillaume Rougier, Antoine Dubray Vautrin, Maria Lesnik, Nathalie Badois, Wahib Ghanem, Jan Klos, Christophe Le Tourneau, Gregoire Marret, Raymond Barnhill, Adel K El-Naggar
INTRODUCTION: Poorly differentiated primary sarcomatoid parotid malignancies are extremely rare. These tumors have not been consistently studied by morphology, immunohistochemistry or molecular techniques. CASE PRESENTATION: We report three unusual cases of parotid gland poorly-differentiated sarcomatoid malignancy investigated by fine needle aspiration and studied histologically, by immunohistochemistry and molecular investigations. Aspirates showed poorly specific polymorphous sarcomatoid malignancy in all cases...
March 4, 2024: Acta Cytologica
https://read.qxmd.com/read/38431268/combined-photodynamic-therapy-and-transpupillary-thermotherapy-for-small-choroidal-melanoma
#5
REVIEW
Olivia J Rolfe, Andrew L Stark, Hayley R Hamilton, Matthew D'Mellow, Jane M Palmer, Lindsay A McGrath, Sunil K Warrier, William J Glasson
OBJECTIVE: The objective of this study was to determine whether combining verteporfin-based photodynamic therapy (PDT) and transpupillary thermotherapy (TTT) achieves adequate tumour control while maintaining visual acuity in individuals with small choroidal melanoma of amelanotic, melanotic, and variable pigmentation. DESIGN: Individuals with posterior choroidal melanomas up to 3 mm in height underwent verteporfin-based PDT followed by immediate TTT. Further combined laser therapy was performed if a poor response was noted at 12 weeks or beyond...
February 28, 2024: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://read.qxmd.com/read/38422599/clinicopathological-dermoscopic-features-and-circumstances-of-diagnosis-of-amelanotic-or-hypomelanotic-melanoma-a-prospective-multicentric-study-in-the-french-private-medical-sector
#6
JOURNAL ARTICLE
E Lorier Roy, J-Y Gourhant, C Derancourt, N Jouan, A Dupuy, J-F Séi
BACKGROUND: Amelanotic or hypomelanotic melanomas (AHM) are difficult to diagnose, and are often diagnosed late, with a high Breslow index and a poor prognosis. PATIENTS AND METHODS: A total of 226 volunteer dermatologists consulting in private practice in France completed an online form for each new histologically proven case of melanoma diagnosed at their clinic in 2020. This anonymised survey collected data on the clinical, dermoscopic, and histological features of melanoma, as well as the circumstances of diagnosis and initial management...
February 28, 2024: Annales de Dermatologie et de Vénéréologie
https://read.qxmd.com/read/38396026/challenges-in-diagnosing-canine-spindle-cell-tumours-using-immunohistochemistry-illustrated-by-three-nonpigmented-malignant-cases-from-the-nictitating-membrane
#7
JOURNAL ARTICLE
Kristine Bundgaard Kjellingbro, Carolina Naranjo Freixa, Lauge Hjorth Mikkelsen, Steffen Heegaard
BACKGROUND: Nonpigmented malignant spindle cell tumours of the membrana nictitans are rare in dogs. In twenty-three years only three cases have been diagnosed in Scandinavia. This study describes the three cases of malignant tumours of the membrana nictitans recorded by the Eye Pathology Section, University of Copenhagen, Denmark, with reference to the clinical appearance and work-up, the treatment and prognosis, and the histopathological description including immunohistochemistry. The three cases are compared to previous publications on canine tumours of the nictitating membrane...
February 23, 2024: Acta Veterinaria Scandinavica
https://read.qxmd.com/read/38390435/conjunctival-nevus
#8
JOURNAL ARTICLE
Jaxon J Huang, Elyana V T Locatelli, Alberto Chocron, Matthew R Camacho, Sander Dubovy, Carol L Karp, Anat Galor
PURPOSE OF REVIEW: To provide an up-to-date review of the epidemiology, presentation, diagnosis, and treatment options for conjunctival nevi (CN). RECENT FINDINGS: Around 17.2%-42% of all conjunctival tumors have been found to be CN, which most frequently present in White individuals between the first to early third decade of life, with equal distribution between males and females. CN commonly occur in the interpalpebral bulbar conjunctiva with pigmentation ranging from amelanotic to dark...
December 2023: Current Ophthalmology Reports
https://read.qxmd.com/read/38389591/disease-progression-and-death-from-cervical-melanoma-in-a-patient-undergoing-nivolumab-therapy-a-case-report
#9
Mateus Lopes Macêdo, Rafael Everton Assunção Ribeiro da Costa, Cristiane Amaral Dos Reis, Raimundo Gerônimo Da Silva Júnior, Ary Oliveira Pires, Sabas Carlos Vieira
Melanoma of the uterine cervix is an exceedingly rare malignancy that has high recurrence rates and distant metastases. In general, surgery is the preferred treatment for this tumor, and depending on stage additional consideration to radiotherapy and chemotherapy. Immunotherapy has emerged as a new treatment option in this context. The aim of this study was to report a case of melanoma of the uterine cervix that progressed rapidly to death while the patient was undergoing immunotherapy with nivolumab. A 39-year-old woman presented with an amelanotic ulcerated lesion of the uterine cervix in February of 2023...
January 2024: Curēus
https://read.qxmd.com/read/38339241/using-flavonoid-substitution-status-to-predict-anticancer-effects-in-human-melanoma-cancers-an-in-vitro-study
#10
JOURNAL ARTICLE
Katarzyna Jakimiuk, Łukasz Szoka, Arkadiusz Surażyński, Michał Tomczyk
Skin cancers are a dominant type of cancer that impacts millions per year. Cancer is a heterogeneous disease triggered by the irreversible impairment of cellular homeostasis and function. In this study, we investigated the activity of 37 structurally diverse flavonoids to find potentially active substances using two melanoma cell lines: C32 and A375. First, the cytotoxic potential and DNA biosynthesis inhibition of flavonoids were tested to determine the most active compounds in cancer and normal cells. Second, the molecular mechanism of the anticancer activity of flavonoids was elucidated using Western blot and immunofluorescence analyses...
January 23, 2024: Cancers
https://read.qxmd.com/read/38303994/canine-oral-melanoma-with-suspected-pulmonary-metastasis-combination-of%C3%A2-immunotherapy-and-tyrosine-kinase-inhibitor-treatment
#11
Kyung-Ryung Kim, Dong-Hyun Kim, Min-Jung Jung, Dong-Min Sihn, Soon-Wuk Jeong, Jung-Hyun Kim
This case report follows a 10-year-old castrated male Miniature Schnauzer dog presented with a history of incomplete surgical resection of an oral malignant melanoma (amelanotic type) on the right mandible. Melanoma vaccine therapy was administered due to incomplete surgical resection, however, new masses were detected on the contralateral mandible and suspected pulmonary metastasis occurred at 2 weeks and 7 months, respectively, following the first melanoma vaccination...
December 2023: Veterinární Medicína
https://read.qxmd.com/read/38271187/tumor-pigmentation-does-not-affect-light-activated-belzupacap-sarotalocan-treatment-but-influences-macrophage-polarization-in-a-murine-melanoma-model
#12
JOURNAL ARTICLE
Sen Ma, Ruben V Huis In't Veld, Yang Hao, Zili Gu, Cadmus Rich, Maria Chiara Gelmi, Aat A Mulder, Peter A van Veelen, T Khanh H Vu, Thorbald van Hall, Ferry A Ossendorp, Martine J Jager
PURPOSE: Pigmentation in uveal melanoma is associated with increased malignancy and is known as a barrier for photodynamic therapy. We investigated the role of pigmentation in tumor behavior and the response to light-activated Belzupacap sarotalocan (Bel-sar) treatment in a pigmented (wild type) and nonpigmented (tyrosinase knock-out [TYR knock-out]) cell line in vitro and in a murine model. METHODS: The B16F10 (TYR knock-out) was developed using CRISPR/Cas9. After the treatment with light-activated Bel-sar, cytotoxicity and exposure of damage-associated molecular patterns (DAMPs) were measured by flow cytometry...
January 2, 2024: Investigative Ophthalmology & Visual Science
https://read.qxmd.com/read/38223263/diagnostic-pathway-from-incidental-mass-to-metastatic-melanoma-role-of-multimodal-imaging-and-medical-therapy
#13
Konstantinos Avranas, Christoph Eisenbach, Christa Flechtenmacher, Grigorios Korosoglou
We present a case of detection of a right atrial mass during surveillance echocardiography, mimicking myxoma. Cardiac magnetic resonance and computed tomography revealed infiltration into the pericardium, suggesting malignancy. Abdominal computed tomography showed multiple liver masses that were histologically positive for metastatic amelanotic melanoma. Under immunotherapy adequate remission was achieved.
January 3, 2024: JACC. Case reports
https://read.qxmd.com/read/38217366/the-combination-of-dermoscopy-and-reflectance-confocal-microscopy-increases-the-diagnostic-confidence-of-amelanotic-hypomelanotic-lentigo-maligna
#14
JOURNAL ARTICLE
Maria Antonietta Pizzichetta, Jerry Polesel, Jean Luc Perrot, Pietro Rubegni, Ignazio Stanganelli, Serena Magi, Laura Mazzoni, Francesca Farnetani, Giovanni Pellacani, Mattia Garutti, Fabio Puglisi, Elisa Cinotti
The dermoscopic diagnosis of amelanotic/hypomelanotic lentigo maligna/lentigo maligna melanoma (AHLM/LMM) may be very difficult in its early stages because of lack of pigment. Reflectance confocal microscopy (RCM) is an imaging technique that is especially helpful for the diagnosis of lentigo maligna. To determine the diagnostic performances of dermoscopy and RCM in the diagnosis of AHLM/LMMs we evaluated dermoscopic and RCM images of consecutive cases of histopathologically confirmed AHLM/LMMs, amelanotic/hypomelanotic basal cell carcinoma and squamous cell carcinoma (AHBCCs/AHSCCs), amelanotic/hypomelanotic benign lesions (AHBLs), and actinic keratoses (AKs) from five participating centers...
January 13, 2024: Journal of Dermatology
https://read.qxmd.com/read/38125787/analysis-and-prediction-of-5-year-survival-in-patients-with-cutaneous-melanoma-a-model-based-period-analysis
#15
JOURNAL ARTICLE
Suzheng Zheng, Hai Yu, Xinkai Zheng, U Tim Wu, Wai-Kit Ming, Hui Huang, Jiaxin Song, Xiaoxi Zhang, Jun Lyu, Liehua Deng
BACKGROUND: The survival and prognosis of patients are significantly threatened by cutaneous melanoma (CM), which is a highly aggressive disease. It is therefore crucial to determine the most recent survival rate of CM. This study used population-based cancer registry data to examine the 5-year relative survival rate of CM in the US. METHODS: Period analysis was used to assess the relative survival rate and trends of patients with CM in the Surveillance, Epidemiology, and End Results (SEER) database during 2004-2018...
2023: Frontiers in Endocrinology
https://read.qxmd.com/read/38113278/choroidal-amelanotic-mass-with-vermiform-margins-vision-loss-and-extreme-fatigue
#16
JOURNAL ARTICLE
Eleni K Konstantinou, Kevin R Card, Carol L Shields
PURPOSE: To describe a case of a previously healthy middle-aged male with an atypical choroidal mass and fatigue. METHODS: Case report. RESULTS: A 56-year-old Caucasian male presented with decreased vision in the right eye (OD) and a choroidal amelanotic mass OD with subretinal fluid. He received bevacizumab (1.25 mg/0.05 mL) injections by multiple providers without improvement in vision and with tumor progression. Visual acuity was 20/400 OD and 20/25 left eye (OS)...
November 22, 2023: Retinal Cases & Brief Reports
https://read.qxmd.com/read/38094552/the-cytodiagnosis-of-amelanotic-primary-signet-ring-cell-melanoma-at-the-unusual-site-of-the-axilla-a-case-report-of-a-rare-entity
#17
Kaustubh Kharche, Arvind Bhake
Amelanotic primary signet ring cell melanoma is a rare variant of cutaneous malignant melanoma. The diagnosis of amelanotic primary signet ring cell melanoma is rarely made based on cytological examinations. Most of the cases reported in the routine practice involve metastatic lesions of known cutaneous amelanotic primary signet ring cell melanoma. The diagnosis of amelanotic primary signet ring cell melanoma on fine needle aspiration cytology (FNAC) is scarce. We present one such extremely rare diagnosis of amelanotic primary signet ring cell melanoma at the unusual site of the axilla, which was established on FNAC...
November 2023: Curēus
https://read.qxmd.com/read/38077197/primary-amelanotic-malignant-melanoma-masquerading-as-adenocarcinoma-prostate-a-pathological-dilemma
#18
Jeena Raju Kudunthail, Arjun Singh Sandhu, Aasma Nalwa, Deepak Prakash Bhirud
A rare disease at an aberrant location can mimic a usual presentation of another disease. We report a case of primary amelanotic malignant melanoma of the prostate with clinical and histological characteristics that closely mimic poorly differentiated adenocarcinoma prostate.
2023: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://read.qxmd.com/read/38061963/amelanotic-malignant-melanoma-in-a-child
#19
Anwei Chen, Faliang Ren
No abstract text is available yet for this article.
December 6, 2023: Anais Brasileiros de Dermatologia
https://read.qxmd.com/read/38009468/associations-of-social-vulnerability-with-truncal-and-extremity-melanomas-in-the-united-states
#20
JOURNAL ARTICLE
Ansh Goyal, David J Fei-Zhang, Timothy M Pawlik, David J Bentrem, Jeffrey D Wayne
BACKGROUND: Prior studies in social determinants (SDoH) of truncal-extremity melanomas (TEM) have analyzed race, income, and environmental factors relative to their effect on health disparities. However, they are limited by the narrow scopes of SDoH and study population, while lacking analyses of interrelational contribution of SDoH on TEM disparities. METHODS: This retrospective cohort study of adult TEM patients (1975-2017) assessed linear regression trends in months of survival, as well as logistic regression trends in advanced presenting stage, surgery, and chemotherapy receipt across TEM subtypes with increasing overall social vulnerability and vulnerability in 15 SDoH variables grouped into socioeconomic status (SES), minority-language status (ML), household composition (HH), and housing-transportation (HT) themes measured by the SVI...
November 27, 2023: Journal of Surgical Oncology
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