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Amelanotic melanoma

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https://www.readbyqxmd.com/read/29166513/primary-cutaneous-amelanotic-melanoma-and-gastrointestinal-stromal-tumor-in-synchronous-evolution
#1
Fernanda Teixeira Ortega, Rogério Nabor Kondo, Francine Milenkovich Belinetti, Mariana Onuki Okamura, Bruna Tuma
Gastrointestinal stromal tumor is rare digestive tract mesenchymal tumor, most often in the wall of the stomach. It is a benign neoplasm, but it can become malignant if not treated. We report a case of gastrointestinal stromal tumor that was discovered after abdominal ultrasonography during staging of a patient with primary cutaneous amelanotic melanoma. Mutation in the tyrosine kinase receptor could explain the development of two types of tumors in the same patient.
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29141067/an-elusive-amelanotic-melanoma-and-review-of-dermoscopic-findings
#2
Anthony Chiaravalloti, Ali Banki
<p>Amelanotic melanoma (AM) is one of the great masqueraders in dermatology. It is a very difficult clinical diagnosis to make because these tumors are devoid of pigment and other clues of melanoma. They are commonly misdiagnosed clinically as other benign and malignant conditions. We present a new case of AM in an 84-year-old woman with a history of non-melanoma skin cancer. She had a thin pink plaque that was initially misdiagnosed as a basal cell carcinoma. We also discuss dermoscopy and its valuable role to improve diagnostic accuracy...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29126970/malignant-melanoma-presenting-as-amelanotic-caruncular-lesion-in-a-child
#3
Alexander R Walters, Katie M Keck, Oliver Simmons, Sarah G Williams, Stephen Cross, Rakesh M Patel
Conjunctival melanoma is a relatively rare malignant neoplasm that can present in childhood in any part of the conjunctiva. The infrequency with which conjunctival melanoma is encountered in childhood caruncular lesions makes it a formidable but important aspect of the differential diagnosis. We report the case of a 10-year-old boy who presented with a left caruncular lesion. On histopathologic analysis, the lesion was determined to be BRAF-negative invasive melanoma arising in association with melanocytic nevus...
November 7, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29074262/photodynamic-therapy-as-initial-treatment-for-small-choroidal-melanomas
#4
F Jmor, R N Hussain, B E Damato, H Heimann
PURPOSE: To evaluate Verteporfin photodynamic therapy (PDT) as primary treatment for small, posterior choroidal melanoma. DESIGN: Retrospective cohort review. SUBJECTS, PARTICIPANTS AND CONTROLS: Retrospective case note review of 20 patients with small juxtapapillary and juxtafoveal choroidal melanomas treated with PDT at the Liverpool Ocular Oncology Clinic. METHODS: Patient and tumour characteristics, PDT session details, visual acuity and B-scan ultrasonography measurements as well as colour fundus photographs at each examination were collated and analysed...
October 23, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29050454/amelanotic-desmoplastic-melanoma-arising-on-an-occipito-parietal-burn-scar
#5
Ginevra Pertusi, Benedetta Miglino, Roberto Giorgione, Antonio Ramponi, Massimo Gattoni, Paolo Boggio, Stefano Astolfi, Rossana Tiberio, Federica Veronese, Francesca Graziola, Francesca Meli, Federica Bellinzona, Enrico Colombo
No abstract text is available yet for this article.
December 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29037039/synthesis-and-preclinical-evaluation-of-18-f-peg3-fpn-for-the-detection-of-metastatic-pigmented-melanoma
#6
Xiaodong Xu, Lujie Yuan, Lianglan Yin, Yaqun Jiang, Yongkang Gai, Qingyao Liu, Yichun Wang, Yongxue Zhang, Xiaoli Lan
Although (18)F-5-fluoro-N-(2-[diethylamino]ethyl)picolinamide ((18)F-5-FPN) is considered a promising radiopharmaceutical for PET imaging of melanoma, it accumulates at high concentrations in the liver. The aim in this research was to optimize the structure of (18)F-5-FPN with triethylene glycol to reduce liver uptake as well as improve pharmacokinetics, and to evaluate its performance in detection of melanoma liver and lung metastases. (18)F-PEG3-FPN was successfully prepared with a high radiolabeling yield (44...
November 6, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29034279/rare-and-extensive-malignant-melanoma-of-the-oral-cavity-report-of-two-cases
#7
Parviz Deyhimi, Sayed Mohammad Razavi, Shirin Shahnaseri, Saeedeh Khalesi, Solmaz Homayoni, Payam Tavakoli
Primary oral melanomas are uncommon malignant neoplasm of melanocytes origin. The most common site of oral melanoma is maxillary gingiva and hard palate. Oral mucosal melanoma exhibit a pathobiological behavior and clinical features different from cutaneous melanomas. Oral melanomas are often clinically silent which may consequently result in delayed diagnosis; thus, making the prognosis extremely poor. This case report presents clinical, histopathological and immunohistochemical features of two cases of advanced oral melanoma, one pigmented or melanotic melanoma in a 46-year-old female and another amelanotic melanoma in a 59-year-old male patient, with chief complaint of swelling in oral mucosa...
September 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/29033351/mouse-cutaneous-melanoma-induced-by-mutant-braf-arises-from-expansion-and-dedifferentiation-of-mature-pigmented-melanocytes
#8
Corinna Köhler, David Nittner, Florian Rambow, Enrico Radaelli, Fabio Stanchi, Niels Vandamme, Arianna Baggiolini, Lukas Sommer, Geert Berx, Joost J van den Oord, Holger Gerhardt, Cedric Blanpain, Jean-Christophe Marine
To identify the cells at the origin of melanoma, we combined single-cell lineage-tracing and transcriptomics approaches with time-lapse imaging. A mouse model that recapitulates key histopathological features of human melanomagenesis was created by inducing a BRafV600E-driven melanomagenic program in tail interfollicular melanocytes. Most targeted mature, melanin-producing melanocytes expanded clonally within the epidermis before losing their differentiated features through transcriptional reprogramming and eventually invading the dermis...
November 2, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/29020904/nodular-melanoma-is-less-likely-than-superficial-spreading-melanoma-to-be-histologically-associated-with-a-naevus
#9
Yan Pan, Nikki R Adler, Rory Wolfe, Catriona A McLean, John W Kelly
OBJECTIVES: To determine the frequency of naevus-associated melanoma among superficial spreading and nodular subtypes; and to investigate associations between naevus-associated melanoma and other clinico-pathological characteristics. DESIGN, SETTING AND PARTICIPANTS: Cross-sectional study of all patients with nodular and superficial spreading melanomas diagnosed between 1994 and 2015 at the Victorian Melanoma Service, Melbourne. METHODS AND MAIN OUTCOME MEASURES: Clinical and pathological characteristics of naevus-associated and de novo melanomas were assessed in univariable and multivariable logistic regression analyses...
October 16, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/29020893/clinical-practice-guidelines-for-the-diagnosis-and-management-of-melanoma-melanomas-that-lack-classical-clinical-features
#10
Victoria J Mar, Alex J Chamberlain, John W Kelly, William K Murray, John F Thompson
A Cancer Council Australia multidisciplinary working group is currently revising and updating the 2008 evidence-based clinical practice guidelines for the management of cutaneous melanoma. While there have been many recent improvements in treatment options for metastatic melanoma, early diagnosis remains critical to reducing mortality from the disease. Improved awareness of the atypical presentations of this common malignancy is required to achieve this. A chapter of the new guidelines was therefore developed to aid recognition of atypical melanomas...
October 16, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28976625/amelanotic-melanoma-arising-within-a-lesion-of-disseminated-superficial-actinic-porokeratosis-an-unusual-presentation-leading-to-a-novel-therapeutic-approach
#11
Ali Al-Haseni, Pooja Chitgopeker, Jonathan D Ho, Lynne J Goldberg, Debjani Sahni
Disseminated superficial actinic porokeratosis (DSAP) is the most common variant of porokeratosis with a potential for malignant transformation. Its association with malignant melanoma, however, is exceedingly rare. Treatment of DSAP is often ineffective. We report a unique case of amelanotic melanoma arising within a lesion of DSAP. The melanoma was managed surgically, and her DSAP were treated successfully with a novel approach utilizing 5-fluorouracil chemowraps.
October 4, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28969144/amelanotic-signet-ring-cell-melanoma-presenting-as-breast-lump-a-diagnostic-conundrum
#12
Prasath Sathiah, Debasis Gochhait, Subathra Adithan, Sandhya Umamahesweran, Priyadarshini Dehuri
Amelanotic signet ring cell melanoma is one of the rare variants of malignant melanoma. Here we are presenting a case of a 58-year-old female with chief complaints of swelling in the left sternal region/breast, and right cervical region. Contrast Enhanced CT scan showed the two well circumscribed lobular mass lesions with central necrosis in the left breast. The radiologist opined the lesions as intramammary nodes. Biopsy from the larger breast mass lesion showed a tumour with cells arranged in discohesive pattern less with hetrogenos morphology...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28873483/a-rare-case-of-amelanotic-anorectal-melanoma
#13
Nicole A Negbenebor, Edward Feller
We report an exceedingly rare case of amelanotic anorectal melanoma misdiagnosed as hemorrhoids. A 74-year-old man presented with a week's history of "blood on toilet tissue" without bowel complaints or history of cutaneous melanoma. Skin evaluation was normal. Rectal exam was negative for blood, but revealed an anal nodule, interpreted as a hemorrhoid. Hemoglobin was normal; bleeding persisted. After one month, colonoscopy detected a non-pigmented anal lesion. Biopsy showed melanoma. Noncutaneous mucosal melanoma represents 0...
September 1, 2017: Rhode Island Medical Journal
https://www.readbyqxmd.com/read/28853696/amelanotic-melanocytoma-of-the-sella-mimicking-pituitary-adenoma
#14
Boleslaw Lach, Kesava Reddy, Doron D Sommer, Anthony C Whitton, Reena Baweja
We describe a 50-year-old man with a well-demarcated intra- and extrasellar lesion and clinical signs of a non-functioning pituitary adenoma. Neuropathological examination revealed tumor composed of non-pigmented spindle cells arranged in tightly packed nests separated by delicate vascular septae. There was no significant cellular atypia or mitotic activity, and Ki67-positive nuclei were present in less than 1% of cells. The neoplastic cells were positive for S-100 and vimentin, and negative for numerous cellular markers including HMB45, anti-melanoma cocktail antibodies, and Masson melanin stain...
August 30, 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/28846171/dermoscopy-and-the-diagnosis-of-primary-cutaneous-b-cell-lymphoma
#15
S Geller, A A Marghoob, A Scope, R P Braun, P L Myskowski
BACKGROUND: Primary cutaneous B-cell lymphomas (PCBCLs) are frequently misdiagnosed, and a biopsy is needed to attain the correct diagnosis. OBJECTIVE: To characterize the dermoscopic features of PCBCL. METHODS: In this retrospective observational study, we analysed the pathology reports of 172 newly diagnosed PCBCL for the initial clinical differential diagnosis. The dermoscopic images of 58 PCBCL were evaluated for dermoscopic features. Two dermoscopy experts, who were blinded to the diagnosis and the study objective, evaluated images from 17 cases for a dermoscopic differential diagnosis...
August 28, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28791653/selective-targeting-of-melanoma-using-n-2-diethylaminoethyl-4-18-f-fluoroethoxy-benzamide-4-18-f-febza-a-novel-pet-imaging-probe
#16
Pradeep K Garg, Rachid Nazih, Yanjun Wu, Vladimir P Grinevich, Sudha Garg
BACKGROUND: The purpose of this study was to develop a positron emission tomography (PET) imaging probe that is easy to synthesize and selectively targets melanoma in vivo. Herein, we report the synthesis and preclinical evaluation of N-(2-diethylaminoethyl) 4-[(18)F]Fluoroethoxy benzamide (4-[(18)F]FEBZA). A one-step synthesis was developed to prepare 4-[(18)F]FEBZA in high radiochemical yields and specific activity. The binding affinity, the in vitro binding, and internalization studies were performed using B16F1 melanoma cell line...
August 8, 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28750450/primary-amelanotic-cns-melanoma-case-report-and-literature-review
#17
Simon Mayer, Uwe Max Mauer, René Mathieu, Carsten Hackenbroch, Janine Knupfer, Chris Schulz
No abstract text is available yet for this article.
July 27, 2017: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/28746718/association-of-incident-amelanotic-melanoma-with-phenotypic-characteristics-mc1r-status-and-prior-amelanotic-melanoma
#18
Steven Vernali, Weston T Waxweiler, Patrick M Dillon, Peter A Kanetsky, Irene Orlow, Li Luo, Klaus J Busam, Anne Kricker, Bruce K Armstrong, Hoda Anton-Culver, Stephen B Gruber, Richard P Gallagher, Roberto Zanetti, Stefano Rosso, Lidia Sacchetto, Terence Dwyer, Anne E Cust, David W Ollila, Colin B Begg, Marianne Berwick, Nancy E Thomas
Importance: We previously reported that survival is poorer from histopathologically amelanotic than pigmented melanoma because of more advanced stage at diagnosis. Identifying patients at risk of amelanotic melanoma might enable earlier diagnosis and improved survival; however, the phenotypic characteristics and underlying genetics associated with amelanotic melanoma are unknown. Objective: To determine whether phenotypic characteristics, carriage of MC1R variants, and history of amelanotic melanoma are associated with histopathologically amelanotic melanoma...
October 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28685596/amelanotic-lentigo-maligna-melanoma-mohs-surgery-as-the-definitive-treatment-of-an-invisible-tumour
#19
Marisa Grace Ponzo, Richard Ian Crawford, Irèn Kossintseva
Amelanotic lentigo maligna melanoma represents <2% of melanomas. Diagnosis is delayed owing to the lack of lesion pigmentation and advanced disease at presentation. Excision with appropriate margins is the treatment standard, but the starting point for such margins is often unclear. We describe 2 patients with amelanotic melanoma treated by Mohs micrographic surgery (MMS) that would not have been cleared by wide local excision alone and provide an extensive review of the literature. Both patients presented with histologic diagnoses of malignant melanoma, one with a barely perceptible biopsy site scar on the left infraorbital cheek/lower eyelid (Breslow 1...
July 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28658677/similar-but-different-how-reflectance-confocal-microscopy-may-help-in-the-diagnosis-of-pink-lesions
#20
Federica Ferrari, Sara Bassoli, Giovanni Pellacani, Giuseppe Argenziano, Anna Maria Cesinaro, Caterina Longo
BACKGROUND: Among skin neoplasms, solitary pink tumors represent challenging lesions in clinical practice since they can mimic melanocytic and nonmelanocytic lesions or even inflammatory ones. OBJECTIVE: In this case series we described dermoscopic and confocal features of 2 couples of similar lesions in order to achieve the correct diagnosis and the best therapeutic approach. METHODS: During clinical routine practice, 2 couples of clinically and dermoscopically similar lesions were examined by means of confocal microscopy...
2017: Dermatology: International Journal for Clinical and Investigative Dermatology
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