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Amelanotic melanoma

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https://www.readbyqxmd.com/read/28431412/cutaneous-malignant-melanoma-with-rhabdoid-morphology-and-smooth-muscle-differentiation-a-challenging-histopathologic-diagnosis
#1
Lucía Prieto-Torres, Victoria Alegría-Landa, Concepción Llanos, Alicia Córdoba, Heinz Kutzner, Luis Requena
Divergent differentiation or metaplastic change is a rare feature exhibited occasionally in malignant melanoma (MM), which is characterized by the development of morphologically, immunochemically, and/or ultrastructurally nonmelanocytic cells within the tumor. Smooth muscle differentiation in MM is an exceedingly rare phenomenon reported only in a few cases in the literature. We report the case of a 69-year-old woman who presented with a pure dermal amelanotic MM with smooth muscle cell differentiation and an area of rhabdoid morphology, which made the accurate histopathologic diagnostic of MM challenging...
May 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28423984/congenital-amelanotic-melanoma-in-a-crossbred-heifer-calf
#2
Christine M Winslow, Jason Wood, John N Gilliam, Melanie A Breshears
A large, pedunculated cutaneous mass protruding from the left flank fold and an enlarged left prefemoral lymph node were found on examination of a 3-d-old crossbred Aberdeen Angus heifer. The calf was asymptomatic aside from peripheral lymphadenopathy, and the mass, along with the left prefemoral lymph node, was surgically excised. Histologic examination of the mass and the lymph node revealed a homogeneous population of neoplastic cells that stained positively with immunohistochemical stains S100 and melan A, supporting a diagnosis of congenital amelanotic melanoma with nodal metastasis...
April 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28388343/orbital-melanoma-masquerading-as-a-galloping-haemangioma
#3
Daniele Lorenzano, Katherine Miszkiel, Geoffrey E Rose
We describe a 32-year-old pregnant woman who was referred to our clinic after 6 weeks of observation elsewhere with a rapidly expanding orbital mass, proptosed globe and slowly decreasing of vision in her left eye. To our examination the patient presented with congested optic disc fine macular striae and some slight choroidal elevation without any retinal pigmentation. An MRI scan without contrast was performed, suggesting the signal charactheristics of an orbital mass consistent with a cellular lesion such as a cavernous hemangioma or a solitary fibrous tumour...
April 2017: Orbit
https://www.readbyqxmd.com/read/28382139/in-vivo-imaging-of-experimental-melanoma-tumors-using-the-novel-radiotracer-68-ga-nodaga-procainamide-pca
#4
István Kertész, András Vida, Gábor Nagy, Miklós Emri, Antal Farkas, Adrienn Kis, János Angyal, Noémi Dénes, Judit P Szabó, Tünde Kovács, Péter Bai, György Trencsényi
PURPOSE: The most aggressive form of skin cancer is the malignant melanoma. Because of its high metastatic potential the early detection of primary melanoma tumors and metastases using non-invasive PET imaging determines the outcome of the disease. Previous studies have already shown that benzamide derivatives, such as procainamide (PCA) specifically bind to melanin pigment. The aim of this study was to synthesize and investigate the melanin specificity of the novel (68)Ga-labeled NODAGA-PCA molecule in vitro and in vivo using PET techniques...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28377036/regression-patterns-of-iris-melanoma-after-palladium-103-103-pd-plaque-brachytherapy
#5
Sonal S Chaugule, Paul T Finger
PURPOSE: To evaluate the patterns of regression of iris melanoma after treatment with palladium-103 ((103)Pd) plaque brachytherapy. DESIGN: Retrospective, nonrandomized, interventional case series. PARTICIPANTS: Fifty patients with primary malignant melanoma of the iris. METHODS: Palladium-103 plaque brachytherapy. MAIN OUTCOME MEASURES: Changes in tumor size, pigmentation, and vascularity; incidence of iris neovascularization; and radiation-related complications...
April 1, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28298867/stones-bones-groans-thrones-and-psychiatric-overtones-systemic-associations-of-sclerochoroidal-calcification
#6
Jordan A Sugarman, Alexzandra M Douglass, Emil Anthony T Say, Carol L Shields
Sclerochoroidal calcification (SCC) is a frequent masquerader of choroidal melanoma with important systemic associations such as hyperparathyroidism and parathyroid adenoma. Herein, we describe a case of a 67-year-old male who presented with an amelanotic choroidal lesion in the right eye (OD) and a history of kidney stones. Ultrasonography showed the lesion to be flat and calcified OD. Incidentally, a subclinical calcified plaque was also found in the fellow eye. Optical coherence tomography showed an elevated suprachoroidal mass in a table mountain configuration OD and flat configuration left eye, consistent with type 4 and type 1 SCC...
January 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/28287037/uva-radiation-augments-cytotoxic-activity-of-psoralens-in-melanoma-cells
#7
Dorota Wrześniok, Artur Beberok, Jakub Rok, Marcin Delijewski, Anna Hechmann, Martyna Oprzondek, Zuzanna Rzepka, Barbara Bacler-Żbikowska, Ewa Buszman
PURPOSE: Melanoma is an aggressive form of skin cancer. The aim of the study was to evaluate the influence of UVA radiation and psoralens: 5-methoxypsoralen (5-MOP) or 8-methoxypsoralen (8-MOP) on melanoma cells viability. MATERIALS AND METHODS: The amelanotic C32 and melanotic COLO829 human melanoma cell lines were exposed to increasing concentrations of psoralens (0.1-100 μM) in the presence or absence of UVA radiation. Cell viability was evaluated by the WST-1 assay...
March 13, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28281027/proteasome-inhibitors-against-amelanotic-melanoma
#8
Justyna Sidor-Kaczmarek, Mirosława Cichorek, Jan Henryk Spodnik, Sławomir Wójcik, Janusz Moryś
The incidence of malignant melanoma, the most aggressive skin cancer, is increasing constantly. Despite new targeted therapies, the prognosis for patients with metastatic disease remains poor. Thus, there is a need for new combinational treatments, and antineoplastic agents potentially valuable in this approach are inhibitors of the ubiquitin-proteasome system (UPS). In this work, we analyze the cytotoxicity mechanisms of proteasome inhibitors (MG-132, epoxomicin, and lactacystin) in a specific form of melanoma which does not synthesize melanin-the amelanotic melanoma (Ab cells)...
March 9, 2017: Cell Biology and Toxicology
https://www.readbyqxmd.com/read/28273977/amelanotic-melanoma-arising-in-filarial-leg-a-report-of-a-rare-case
#9
Mamita Nayak, Susama Patra, Susanta Meher, Prakash Kumar Sasmal
Amelanotic melanoma arising on chronic lymphoedema has not been reported earlier. We reported a case of amelanotic melanoma of right leg developing in a background of chronic lymphoedema of filarial origin in an elderly male of 60 years, who underwent wide local excision of the lesion followed by skin grafting for the same. A histopathological diagnosis of amelanotic melanoma was made. The patient was on follow up when he developed brain metastasis within a period of nine months for which he was operated and is on regular follow up now...
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28273651/comparative-preclinical-evaluation-of-68-ga-nodaga-and-68-ga-hbed-cc-conjugated-procainamide-in-melanoma-imaging
#10
György Trencsényi, Noémi Dénes, Gábor Nagy, Adrienn Kis, András Vida, Flóra Farkas, Judit P Szabó, Tünde Kovács, Ervin Berényi, Ildikó Garai, Péter Bai, János Hunyadi, István Kertész
Malignant melanoma is the most aggressive form of skin cancer. The early detection of primary melanoma tumors and metastases using non-invasive PET imaging determines the outcome of this disease. Previous studies have shown that benzamide derivatives (e.g. procainamide) conjugated with PET radionuclides specifically bind to melanin pigment of melanoma tumors. (68)Ga chelating agents can have high influence on physiological properties of (68)Ga labeled bioactive molecules, as was experienced during the application of HBED-CC on PSMA ligand...
May 30, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28252554/clinical-and-dermoscopic-features-of-truly-amelanotic-plantar-melanoma
#11
Vincenzo De Giorgi, Alessia Gori, Imma Savarese, Antonietta D'Errico, Federica Papi, Marta Grazzini, Federica Scarfì, Piero Covarelli, Daniela Massi
Currently, there are no specific clinical and dermoscopic features for diagnosing truly amelanotic plantar melanoma (TAPM). The present study aimed to investigate the dermoscopic features of all clinical variants of TAMPS and to evaluate their histopathological correlations. A retrospective analysis of prospectively collected data was carried out during a 10-year period (2003-2013). We analyzed the clinical data of 1321 patients, who had received a histological diagnosis of melanoma at the Melanoma Unit of the University of Florence...
March 1, 2017: Melanoma Research
https://www.readbyqxmd.com/read/28247222/update-from-the-4th-edition-of-the-world-health-organization-classification-of-head-and-neck-tumours-mucosal-melanomas
#12
Michelle D Williams
The updated edition of The World Health Organization Classification of Tumours of the Head and Neck includes discussions on mucosal melanoma of both the sinonasal and oral cavity. Since the prior edition, sinonasal origin is now recognized as the most common site of occurrence of mucosal melanoma in the head and neck (66%) with oral cavity representing 25% of cases. Histologic features of mucosal melanomas vary widely from spindled, epithelioid, and pleomorphic to rhabdoid, plasmacytoid and undifferentiated...
March 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28243493/proposal-for-management-and-dermoscopy-follow-up-of-nevi-in-patients-affected-by-oculocutaneous-albinism-type-ia
#13
Rosario Peralta, Emilia Cohen Sabban, Paula Friedman, Carolina Marcucci, Luis A Bollea Garlatti, Gastón Galimberti, Horacio Cabo
Albino patients are at great risk for developing cutaneous neoplasms, including melanomas. In this paper we describe the dermatoscopic findings of nevi in two patients with oculocutaneous albinism type Ia (OCA-Ia) highlighting that they manifest a vascular pattern similar to that described for amelanotic melanoma. We propose managing these patients with dermoscopy, using the comparative approach, digital follow up (DFU), and reflectance confocal microscopy as a complementary tool for difficult cases.
January 2017: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/28191667/metastatic-recurrence-of-17-years-relapse-free-melanoma-during-anti-tnfa-therapy
#14
Ioana Cosgarea, Andreas Körber, Dorothee Dill, Dirk Schadendorf, Selma Ugurel
Tumor-necrosis-factor-alpha (TNFa) is an innate cytokine involved in regulating inflammation, immunity, tumorigenesis, and apoptosis. TNFa inhibitors became a powerful tool in the treatment of auto-immune inflammatory diseases such as Crohn's disease, ulcerative colitis, rheumatoid arthritis and psoriasis. Known side effects of TNFa inhibitors range from infections to malignancies [1]. We report a male patient who was in 1998 at age 36 diagnosed with amelanotic melanoma of the leg, Breslow thickness 11.0 mm, no ulceration...
February 13, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28171845/a-first-reported-case-of-metastatic-anorectal-amelanotic-melanoma-with-a-marked-response-to-anti-pd-1-antibody-nivolumab-a-case-report
#15
Katsuji Tokuhara, Kazuyoshi Nakatani, Hirotsugu Tanimura, Kazuhiko Yoshioka, Takahiro Kiyohara, Masanori Kon
INTRODUCTION: Anorectal amelanotic melanoma (AAMM) is a rare disease with poor prognosis. A standard treatment strategy for AAMM has not been established. PRESENTATION OF CASE: We report a case of successful treatment of AAMM with nivolumab. A 67-year-old man was referred for colonoscopy which revealed type I tumor in the rectum. AAMM was diagnosed with immunostaining histopathological biopsy findings. Enhanced computed tomography (ECT) revealed the rectal tumor without distant organ metastasis...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28140538/self-detection-frequency-and-recognition-patterns-in-medium-to-high-risk-cutaneous-melanoma-patients
#16
Anca Sindrilaru, Vera Neckermann, Thomas Eigentler, Panagiotis Kampilafkos, Diana Crisan, Nicolai Treiber, Karin Scharffetter-Kochanek, Lars Alexander Schneider
BACKGROUND AND OBJECTIVES: The question of how frequently patients with medium to high-risk melanomas become aware of their tumors and which self-detection patterns exist remains unanswered. PATIENTS AND METHODS: We conducted a retrospective survey of melanoma patients who had undergone sentinel node biopsy between 2004 and 2008. One hundred twenty-seven out of a total of 133 patients completed the questionnaire. RESULTS: Twenty-five percent of patients had not noticed their tumors at all...
January 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28100848/influence-of-28-o-propynoylbetulin-on-proliferation-and-apoptosis-of-melanotic-and-amelanotic-human-melanoma-cells
#17
Anna Kaps, Ewa Chodurek, Arkadiusz Orchel, Marzena Jaworska-Kik, Ewa Bębenek, Stanisław Boryczka, Janusz Kasperczyk
INTRODUCTION: A relatively new approach in treatment of malignant melanoma is the use of betulin and its synthetic derivatives that have anticancer properties. The aim of the study was to determine the effect of an acetylenic derivative of betulin, 28-O-propynoylbetulin, on cell growth and apoptosis induction in human melanotic and amelanotic melanoma cells. MATERIALS AND METHODS: The A2058 and C32 cell lines were incubated with 28-O-propynoylbetulin (working solutions from 0...
December 31, 2016: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28092878/amelanotic-melanoma-in-the-bone-marrow
#18
Shireen Kassam, Chirag Shah
No abstract text is available yet for this article.
July 14, 2016: Blood
https://www.readbyqxmd.com/read/28064232/primary-vaginal-melanoma-a-rare-and-aggressive-entity-a-case-report-and-review-of-the-literature
#19
Emmanouil Kalampokas, Theodoros Kalampokas, Christos Damaskos
Malignant melanoma of the vagina is a rare, aggressive malignancy of poor prognosis. It principally affects post-menopausal women, with a mean age of 57 years, and the factors that contribute to its appearance are not well known. The first case of primary malignant vaginal melanoma was reported in 1887 and modern literature has noted about 500 cases, globally. Vaginal melanomas constitute 0.3% of all malignant melanomas and fewer than 3% of all vaginal carcinomas. To date there is no clear consensus regarding treatment...
January 2, 2017: In Vivo
https://www.readbyqxmd.com/read/28045747/next-generation-sequencing-reveals-pathway-activations-and-new-routes-to-targeted-therapies-in-cutaneous-metastatic-melanoma
#20
J Andrew Carlson, Jose Candido Caldeira Xavier, Ashley Tarasen, Christine E Sheehan, Geoff Otto, Vincent A Miller, Philip J Stephens, Julia A Elvin, Jo-Anne Vergilio, James Suh, Laurie M Gay, Jeffrey S Ross
BACKGROUND: Comprehensive genomic profiling of clinical samples by next-generation sequencing (NGS) can identify one or more therapy targets for the treatment of metastatic melanoma (MM) with a single diagnostic test. METHODS: NGS was performed on hybridization-captured, adaptor ligation-based libraries using DNA extracted from 4 formalin-fixed paraffin-embedded sections cut at 10 microns from 30 MM cases. The exons of 182 cancer-related genes were fully sequenced using the Illumina HiSeq 2000 at an average sequencing depth of 1098X and evaluated for genomic alterations (GAs) including point mutations, insertions, deletions, copy number alterations, and select gene fusions/rearrangements...
January 2017: American Journal of Dermatopathology
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