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https://www.readbyqxmd.com/read/29771758/opportunistic-fungal-infection-in-children-and-management
#1
Joseph M Lam
PURPOSE OF REVIEW: An opportunistic mycosis is a fungal agent of low pathogenicity that specifically infects immunocompromised hosts. Advances in transplantation, preterm care, immunosuppressive therapies and intensive care, have lead to the emergence of pediatric patients with serious immunodeficiency who are vulnerable to nonpathogenic fungi. RECENT FINDINGS: The advent of the use of biologic agents in pediatric disease as well as the advances in care of preterm and immunosuppressed patients opens up a new cohort of patients at risk of opportunistic mycotic infections...
May 15, 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29768547/clinical-outcomes-and-risk-factors-for-death-from-disseminated-histoplasmosis-in-patients-with-aids-who-visited-a-high-complexity-hospital-in-campo-grande-ms-brazil
#2
Barbara Cristina Scarcelli Boigues, Anamaria Mello Miranda Paniago, Gláucia Moreira Espíndola Lima, Maina de Oliveira Nunes, Silvia Naomi de Oliveira Uehara
INTRODUCTION: Disseminated histoplasmosis (DH) is a systemic mycosis caused by Histoplasma capsulatum (H. capsulatum) and is characterized by progressive and fatal evolution in immunocompromised patients. Moreover, it is considered an AIDS-defining disease. METHODS: We performed an observational, analytical, retrospective study to identify the clinical outcomes and risk factors for death from DH in patients with AIDS at an infectious diseases service facility in Brazil between September 2011 and July 2016...
March 2018: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29762233/adrenal-histoplasmosis
#3
Vanessa Sanders, Joseph Donald, Barry A Siegel
An 89-year-old woman presented with seizure and hyponatremia. CT and MRI demonstrated mass-like enlargement of the adrenal glands and multiple pulmonary nodules. PET/CT performed to evaluate for metastatic disease demonstrated intense 18F-FDG uptake within enlarged adrenal glands. Given mild uptake in the pulmonary nodules, the differential diagnosis for the adrenal uptake included lymphoma, granulomatous infection, and less likely, metastatic lung cancer.
May 14, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29744231/recurrent-pneumonia-due-to-fibrosing-mediastinitis-in-a-teenage-girl-a-case-report-with-long-term-follow-up
#4
Avigdor Hevroni, Chaim Springer, Oren Wasser, Avraham Avital, Benjamin Z Koplewitz
A teenage girl was evaluated for recurrent right pneumonia. The evaluation revealed a calcified mediastinal mass that compressed the right intermediate and middle lobar bronchi, as well as the right pulmonary artery and veins. The clinical picture together with imaging studies and borderline positive serology testing suggested a diagnosis of fibrosing mediastinitis associated with histoplasmosis. This rare condition is characterized by the local proliferation of invasive fibrous tissue within the mediastinum due to a hyperimmune reaction to Histoplasma capsulatum ...
2018: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/29742119/prior-subclinical-histoplasmosis-revealed-in-nigeria-using-histoplasmin-skin-testing
#5
Rita O Oladele, Conchita Toriello, Folasade T Ogunsola, Olusola O Ayanlowo, Philip Foden, Adetona S Fayemiwo, Iriagbonse I Osaigbovo, Anthony A Iwuafor, Shuwaram Shettima, Halimat A Ekundayo, Malcolm D Richardson, David W Denning
OBJECTIVES: Disseminated histoplasmosis is an AIDS-defining illness. Histoplasmosis is commonly misdiagnosed as tuberculosis. Nigeria has the second highest number of people living with HIV/AIDS in Africa. The present study was carried out to investigate the prevalence of skin sensitivity amongst Nigerians to histoplasmin. DESIGN: A cross-sectional study was conducted in six centres across five geopolitical zones of Nigeria. METHODS: We recruited both healthy non-HIV and HIV-positive adults with CD4 count ≥ 350 cells/mm3 regardless of their ART status from March to May 2017...
2018: PloS One
https://www.readbyqxmd.com/read/29738315/diagnosis-and-treatment-of-histoplasmosis-in-solid-organ-transplant-patients
#6
Kiran Gajurel, Reshika Dhakal, Stan Deresinski
PURPOSE OF REVIEW: Unlike immunocompetent hosts, solid organ transplant (SOT) recipients with posttransplant histoplasmosis (PTH) often present with disseminated disease and have an attributable mortality of approximately 10%. In this review, we discuss currently available diagnostic tests and treatment strategies in PTH. RECENT FINDINGS: None of the available tests have a 100% diagnostic accuracy. Histoplasma antigen assays are the most sensitive commercially available tests...
May 5, 2018: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29738029/sepsis-like-histoplasmosis-in-a-kidney-transplant-patient
#7
Ana Raquel Fernandes, Laila Almeida Viana, Juliana Busato Mansur, Mariana de Moraes Françoso, Daniel Wagner de Castro Lima Santos, Helio Tedesco Silva, José Osmar Medina Pestana
Histoplasmosis is a fungus infection that mainly affects immunosuppressed patients. The authors present a case of a kidney transplant recipient who developed sepsis-like histoplasmosis, na atypical but severe manifestation of the disease. The fungus was found in blood and in a skin biopsy, and the treatment with liposomal amphotericin resulted in hepatotoxicity.
April 23, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29735828/histoplasmosis-in-non-endemic-north-western-part-of-india
#8
Atul K Patel, Ketan K Patel, Harsh Toshniwal, Swati Gohel, Arunaloke Chakrabarti
Purpose of Study: The western and North-Western parts of India are usually considered non-endemic for histoplasmosis. On the contrary, we observe histoplasmosis cases with relatively higher frequency from this region although the awareness and laboratory facility to diagnose the disease are not adequate. Hence, we planned the present retrospective study to compile the cases and to analyse different clinical parameters. Materials and Methods: Medical records of the patients diagnosed with histoplasmosis during January 2012-August 2017 at two infectious disease clinics of Ahmedabad were included in this study...
January 2018: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29730356/not-your-typical-arizona-granuloma-a-case-report-of-disseminated-histoplasmosis-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2
#9
Sara Sani, Jawad Bilal, Elly Varma, Shubha Kollampare, Dominick Sudano
No abstract text is available yet for this article.
May 3, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29729993/vaccination-with-an-alkaline-extract-of-histoplasma-capsulatum-packaged-in-glucan-particles-confers-protective-immunity-in-mice
#10
George S Deepe, William R Buesing, Gary R Ostroff, Ambily Abraham, Charles A Specht, Haibin Huang, Stuart M Levitz
Infection with the dimorphic fungus, Histoplasma capsulatum, occurs world-wide, but North and South America are regions of high endemicity. Interventions to mitigate exposure and consequent disease are limited to remediating a habitat harboring the fungus. The development of a vaccine to prevent infection or lessen its severity is an important advance in disease prevention. Accordingly, we prepared an alkaline extract from the yeast phase of Histoplasma and encased it in glucan particles that act as an adjuvant and delivery vehicle...
May 2, 2018: Vaccine
https://www.readbyqxmd.com/read/29695056/burden-of-serious-fungal-infections-in-argentina
#11
Fernando O Riera, Juan P Caeiro, David W Denning
The number of fungal infections at any given time in Argentina is not known. Here we estimate the burden of serious fungal infections in Argentina for the first time. Specific population statistics were searched from multiple sources, local literature was identified, and estimates made. Some additional data were sourced from the Ministry of Health, the Global Initiative for Asthma (GINA) program, and national haematology and transplant societies. Argentina has a population of 43.8 million, with 25% of this total being children under 15 years...
April 24, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29687336/clinical-efficacy-and-safety-of-current-interventions-for-choroidal-neovascularization-associated-with-rare-diseases-a-systematic-literature-review
#12
REVIEW
Natalie Bennett, Lokho John, Nishkarsh Likhar, Rumjhum Agrawal, Winfried M Amoaku
INTRODUCTION: The aim of this systematic literature review was to evaluate the efficacy and safety of interventions for the treatment of choroidal neovascularization (CNV) secondary to etiologies other than age-related macular degeneration and pathologic myopia. METHODS: Relevant randomized controlled trials (RCTs) and prospective observational studies were identified by searching MEDLINE, MEDLINE In-Process, EMBASE, and CENTRAL. RESULTS: The search identified 5 RCTs; no relevant observational studies were identified...
April 23, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29668643/central-nervous-system-histoplasmosis-multicenter-retrospective-study-on-clinical-features-diagnostic-approach-and-outcome-of-treatment-erratum
#13
(no author information available yet)
No abstract text is available yet for this article.
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29666076/histoplasma-meets-crohn-s-disease-a-rare-case-of-new-onset-ascites
#14
Charles Robert Bosshardt, John Gnann, Nilesh Lodhia
A 53-year-old man with Crohn's disease treated with adalimumab was hospitalised with abdominal pain, fatigue, fever and chills. CT scan of the abdomen showed chronic thickening of the terminal ileum and cecum and new-onset ascites. Further studies revealed weakly positive urine and serum histoplasma antigen. Laparoscopy revealed metastatic caking of the omentum and abdominal wall; peritoneal biopsy demonstrated organisms morphologically consistent with Histoplasma capsulatum No dissemination outside of the peritoneal cavity was evident...
April 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29657917/hemophagocytic-lymphohistiocytosis-hlh-secondary-to-disseminated-histoplasmosis-in-the-setting-of-acquired-immunodeficiency-syndrome-aids
#15
Samuel Asanad, Brendan Cerk, Veronica Ramirez
Hemophagocytic lymphohistiocytosis (HLH) is a rare and aggressive disease involving immune system over-activation leading to hemophagocytosis. HLH requires early diagnosis and prompt treatment initiation, especially in patients with Acquired Immunodeficiency Syndrome (AIDS). We present a case of a middle-aged male with AIDS and renal failure, who developed HLH secondary to disseminated histoplasmosis. Etoposide chemotherapy as recommended by the HLH 2004 Guidelines was deferred and treatment focused instead on anti-fungal therapy...
June 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29651354/evolution-of-choroidal-neovascularization-due-to-presumed-ocular-histoplasmosis-syndrome-on-multimodal-imaging-including-optical-coherence-tomography-angiography
#16
T Y Alvin Liu, Alice Yang Zhang, Adam Wenick
A 37-year-old Caucasian woman presented with acute decrease in central vision in her right eye and was found to have subfoveal choroidal neovascularization (CNV) due to presumed ocular histoplasmosis syndrome (POHS). Her visual acuity improved from 20/70 to 20/20 at her 6-month follow-up, after 3 consecutive monthly intravitreal bevacizumab injections were initiated at her first visit. Although no CNV activity was seen on fluorescein angiography (FA) or spectral-domain optical coherence tomography (SD-OCT) at her 2-month, 4-month, and 6-month follow-up visits, persistent flow in the CNV lesion was detected on optical coherence tomography angiography (OCTA)...
2018: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/29643659/endoscopic-ultrasound-guided-cytodiagnosis-of-adrenal-histoplasmosis-with-reversible-cd4-t-lymphocytopenia-and-jejunal-lymphangiectasia
#17
Rakesh K Gupta, Kaushik Majumdar, Siddharth Srivastava, Shivakumar Varakanahalli, Ravindra K Saran
No abstract text is available yet for this article.
April 2018: Journal of Cytology
https://www.readbyqxmd.com/read/29643654/role-of-endoscopic-ultrasound-guided-fine-needle-aspiration-in-adrenal-lesions-analysis-of-32-patients
#18
Rakesh K Gupta, Kaushik Majumdar, Ravindra K Saran, Siddharth Srivastava, Puja Sakhuja, Vineeta V Batra
Objective: Endoscopic ultrasound-guided fine-needle aspiration cytology (EUS-FNAC) is a precise and safe technique that provides both radiological and pathological diagnosis with a better diagnostic yield and minimal adverse events. EUS-FNAC led to the remarkable increase in the detection rate of incidentaloma found during radiologic staging or follow-up in various malignancy or unrelated conditions. Aims: We did this preliminary study with an aim to evaluate the role of EUS-FNA in diagnosing and classifying adrenal lesions, clinical impact, and compare the outcome with the previously published literature...
April 2018: Journal of Cytology
https://www.readbyqxmd.com/read/29627936/invasive-fungal-infections-associated-with-prior-respiratory-viral-infections-in-immunocompromised-hosts
#19
Saira Ajmal, Maryam Mahmood, Omar Abu Saleh, Jenifer Larson, M Rizwan Sohail
BACKGROUND: Increased risk of invasive pulmonary aspergillosis after influenza infection has been reported; however data are limited. PURPOSE: To describe Invasive fungal infections (IFI) associated with preceding respiratory viral infection at a large referral center. METHODS: We reviewed all IFI cases among patients with positive influenza and/or RSV nasopharyngeal/lower respiratory tract PCR from October 2015 to December 2016. Cases of pulmonary IFI were classified as possible, probable, and definite based on EORTC-MSG definitions...
April 7, 2018: Infection
https://www.readbyqxmd.com/read/29623159/diagnosing-ring-enhancing-lesions-in-the-brain-of-a-patient-with-aids-without-brain-biopsy-a-case-of-central-nervous-system-histoplasmoma
#20
Rachel Beekman, Jessica M Hu, Steven I Aronin, Maricar F Malinis
We report a case of a Puerto Rican male with advanced AIDS who presented with multiple falls and pancytopenia. Magnetic resonance imaging (MRI) of the brain, as initial workup, revealed 2 ring-enhancing brain lesions. Initial cerebrospinal fluid analysis revealed minimal cells, mildly elevated protein, and no organism seen on gram stain. Due to prohibitive thrombocytopenia, brain biopsy was deferred. He had neither clinical nor radiographic improvement despite empiric therapy for both toxoplasmosis and bacterial abscesses...
April 2018: Neurohospitalist
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