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https://www.readbyqxmd.com/read/29122900/a-30-year-delayed-presentation-of-disseminated-histoplasmosis-in-a-heart-transplant-recipient-diagnostic-challenges-in-a-non-endemic-area
#1
Aneela Majeed, Vikas Kapoor, Azka Latif, Tirdad Zangeneh
A 70-year-old man with history of heart transplant performed in 1986, presented with altered mental status. CT scan of brain showed ring-enhancing lesions, raising suspicion for metastatic malignancy. Work-up revealed bilateral adrenal masses, biopsy showed granulomatous changes consistent with histoplasmosis. The possibility of histoplasmosis was less likely as the patient had no prior history of symptomatic disease and had lived in the endemic area 30 years prior to presentation. Brain biopsy confirmed central nervous system involvement...
November 8, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29109880/an-unusual-subcutaneous-mass-in-an-otherwise-healthy-patient-a-case-report-of-localized-histoplasmosis-diagnosed-on-excisional-biopsy
#2
Brendon M Esquibel, Christine J Waller, William A Agger
Patients are commonly referred to general surgery clinics for evaluation of soft-tissue masses of the trunk and extremities. The primary goal of surgical referral is to confirm the presence of a mass, to assess the need for additional imaging and/or testing, and to gauge amenability to surgical biopsy, whether incisional or excisional. This is a case of a 67-year-old woman who was referred to surgery clinic for a small soft-tissue mass near her left elbow that had increased in size and pain over the past year...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29082045/h-capsulatum-a-not-so-benign-cause-of-pericarditis
#3
Paolo K Soriano, Muhammad Iqbal, Shakthishri Kandaswamy, Sami Akram, Abhishek Kulkarni, Tamer Hudali
The common causes of pericarditis and its course are benign in the majority of cases. Thus, further testing is usually not pursued and treatment for a presumptive viral etiology with nonsteroidal agents and steroids has been an accepted strategy. We present a patient with pericarditis who was unresponsive to first-line therapy and was subsequently found to have necrotizing granulomas of the pericardium with extensive adhesions and fungal elements seen on tissue biopsy. Serologic testing confirms active H. capsulatum infection, and he responded well to Itraconazole treatment...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/29081364/usefulness-of-thick-blood-smears-in-the-diagnosis-of-disseminated-histoplasmosis
#4
José Y Rodríguez, Gerson J Rodríguez, Maria J Mendoza, Carlos A Álvarez-Moreno
No abstract text is available yet for this article.
November 9, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29080114/a-twenty-first-century-perspective-of-disseminated-histoplasmosis-in-india-literature-review-and-retrospective-analysis-of-published-and-unpublished-cases-at-a-tertiary-care-hospital-in-north-india
#5
REVIEW
Ayush Gupta, Arnab Ghosh, Gagandeep Singh, Immaculata Xess
PURPOSE: Published literature lacks systematic studies on disseminated histoplasmosis in India, and previous reviews on its epidemiology in India were conducted two decades back. Thus, we review the Indian studies published in this century to understand the recent epidemiology of histoplasmosis in India and do a retrospective analysis of all cases diagnosed at our institute. METHODS: A literature of review search was done in Pubmed/Medline and Scopus. Studies published during January 2001-December 2015 were considered along with retrospective analysis of cases presented to us...
December 2017: Mycopathologia
https://www.readbyqxmd.com/read/29046010/-differential-diagnosis-of-mediastinal-and-hilar-lymphadenopathy-with-focus-on-occupational-diseases
#6
H Lux, L Barreira Cavalcante, X Baur
Hilar and mediastinal lymphadenopathy may represent a diagnostic challenge in clinical practice. This article is intended to facilitate differential diagnosis by a systematic description of relevant pathologies, notably with occupational etiology. Clinical findings of relevant diseases, i. e. of tuberculosis, chronic beryllium disease, sarcoidosis, lung cancer, malignant lymphoma, Epstein-Barr virus infection, and histoplasmosis are compared.Case history, imaging and laboratory tests have important diagnostic impact...
October 18, 2017: Pneumologie
https://www.readbyqxmd.com/read/29030061/disseminated-histoplasmosis-an-unusual-presentation-of-a-classic-midwest-infection
#7
Amrit K Kamboj, Saumya Shah, Subir Bhatia, Carl Andersen, Cyril Varghese
No abstract text is available yet for this article.
October 10, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/29024456/disseminated-histoplasmosis-in-an-immuno-competent-young-male-role-of-bone-marrow-examination-in-rapid-diagnosis
#8
Muhammad Shariq Shaikh, Ayesha Majeed Memon
Fungal infections are usually seen in elderly or immuno-compromised individuals particularly with human immunodeficiency virus infection. In immuno-competent individuals, they seldom present with overt clinical symptoms. In such cases diagnosis is made by combination of tests along with direct microscopic visualization of the organism. We present a case of immuno-competent individual who presented with unexplained fever and found to have Histoplasma capsulatum infection on bone marrow examination.
October 11, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29020213/improvement-in-diagnosis-of-histoplasma-meningitis-by-combined-testing-for-histoplasma-antigen-and-igg-and-igm-anti-histoplasma-antibody-in-cerebrospinal-fluid
#9
Karen C Bloch, Thein Myint, Luke Raymond-Guillen, Chadi A Hage, Thomas E Davis, Patty W Wright, Felicia C Chow, Laila Woc-Colburn, Raed N Khairy, Alan C Street, Tomotaka Yamamoto, Amanda Albers, L Joseph Wheat
Background: Central nervous system (CNS) histoplasmosis is a life-threatening condition and represents a diagnostic and therapeutic challenge. Isolation of H. capsulatum from cerebrospinal fluid (CSF) or brain tissue is diagnostic; however, culture is insensitive and slow growth may result in significant treatment delay. We performed a retrospective multicenter study to evaluate the sensitivity and specificity of a new anti-Histoplasma antibody enzyme immunoassay (EIA) for the detection of IgG and IgM antibody in the CSF for diagnosis of CNS histoplasmosis, the primary objective of the study...
August 20, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29016342/case-report-histoplasmosis-in-himachal-pradesh-india-an-emerging-endemic-focus
#10
Vikram K Mahajan, Rashmi Kaul Raina, Suman Singh, Rattan Sagar Rashpa, Anuradha Sood, Pushpinder S Chauhan, Karaninder S Mehta, Ritu Rawat, Vikas Sharma
We describe four cases of histoplasmosis indigenous to Himachal Pradesh (India) that will be of considerable public health interest. A 48-year-old human immunodeficiency virus (HIV)-negative man with cervical and mediastinal lymphadenopathy, hepatosplenomegaly, adrenal mass, and bone marrow involvement was treated as disseminated tuberculosis without benefit. Progressive disseminated histoplasmosis was diagnosed from the fungus in smears from adrenal mass. Another 37-year-old HIV-positive man was on treatment of suspected pulmonary tuberculosis...
September 25, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28992262/a-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-reference-database-for-the-identification-of-histoplasma-capsulatum
#11
Clara Valero, María J Buitrago, Sara Gago, Inmaculada Quiles-Melero, Julio García-Rodríguez
The isolation of the pathogenic fungus Histoplasma capsulatum from cultures together with the visualization of typical intracellular yeast in tissues are the gold standard methods for diagnosis of histoplasmosis. However, cultures are time-consuming, require level 3 containment and experienced personnel, and usually call for an additional confirmation test. Matrix-Assisted Laser Desorption Ionization Time of Flight Mass Spectrometry (MALDI-ToF MS) has been established as a suitable tool for microbial identification in several clinical laboratories...
July 28, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28978596/safe-usage-of-anakinra-and-dexamethasone-to-treat-refractory-hemophagocytic-lymphohistiocytosis-secondary-to-acute-disseminated-histoplasmosis-in-a-patient-with-hiv-aids
#12
Anthony J Ocon, Birju D Bhatt, Cynthia Miller, Ruben A Peredo
Hemophagocytic lymphohistiocytosis (HLH) is a serious life-threatening disease if not recognised early. In patients with HIV/AIDS, this association has been reported following acute opportunistic infections, including histoplasmosis. However, optimal treatment is not known. We describe a male aged 46 years with AIDS who developed HLH following acute disseminated histoplasmosis. Presenting symptoms included fever, hepatosplenomegaly and pancytopenia. Bone marrow biopsy confirmed HLH. Initially, he was refractory to the treatment with amphotericin B, antiretroviral therapy and intravenous immunoglobulin (IVIG)...
October 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28956543/disseminated-histoplasmosis-in-aids-patients-an-urban-disease-experience-in-a-metropolis-in-the-middle-east-of-brasil
#13
Bianca da Silva Ferreira, Joâo Alves de Araújo Filho, Nayara Matos Pereira, Lucas de Miranda Godoy, Bruna Borges Lamounier, Elizon Dias Nunes, Lucas Espíndola Rosa
Histoplasmosis is a fungal disease commonly observed as an opportunistic disease in AIDS patients. It is a neglected disease in many countries, particularly Latin America, including Brazil. It is related with environmental factors, even in urban areas, where the incidence has increased. Implementing a descriptive ecological study, we performed a retrospective chart review for data collected between January 2003 and July 2014 for AIDS patients with histoplasmosis who lived in Goiania. The selected cases were georeferenced to analyse the incidence of histoplasmosis in AIDS patients in the metropolitan area of Goiania...
September 1, 2017: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/28954600/disseminated-histoplasmosis-case-report-and-review-of-the-literature
#14
Séverine Evrard, Philippe Caprasse, Pierre Gavage, Myriam Vasbien, Jean Radermacher, Marie-Pierre Hayette, Rosalie Sacheli, Marjan Van Esbroeck, Lieselotte Cnops, Eric Firre, Laurent Médart, Filip Moerman, Jean-Marc Minon
Case report We report the case of a young Cameroonian woman who presented with cough, hyperthermia, weight loss, pancytopenia, and hepatosplenomegaly. A positive HIV serology was discovered and a chest radiography revealed a 'miliary pattern'. Bone marrow aspiration pointed out yeast inclusions within macrophages. Given the morphological aspect, the clinical presentation and immunosuppression, histoplasmosis was retained as a working hypothesis. Antiretroviral and amphotericin B treatments were promptly initiated...
September 28, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/28934824/acid-fastness-of-histoplasma-in-surgical-pathology-practice
#15
Madhu Rajeshwari, Immaculata Xess, Mehar Chand Sharma, Deepali Jain
BACKGROUND: Histoplasmosis (HP) is diagnosed by visualizing intracellular microorganisms in biopsy and/or culture. Periodic-acid Schiff (PAS) and Gomori methenamine silver (GMS) staining methods are routinely used for identification. The acid-fast property of Histoplasma was identified decades ago, but acid-fast staining has not been practiced in current surgical pathology. Awareness of the acid-fast property of Histoplasma, which is due to mycolic acid in the cell wall, is important in distinguishing Histoplasma from other infective microorganisms...
September 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28920817/intestinal-histoplasmosis-in-a-captive-reindeer-rangifer-tarandus-missouri-usa
#16
Jessica S Fortin, Michael J Calcutt, Dusty W Nagy, Keiichi Kuroki
An infection with Histoplasma capsulatum was diagnosed in a farmed reindeer in Missouri, an endemic area for histoplasmosis, localized in the intestine. The intrahistiocytic organisms were identified in tissue sections using histologic methods and confirmed by immunohistochemistry. This is the first report of histoplasmosis in a reindeer or in any deer species.
September 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28903987/heat-shock-proteins-in-histoplasma-and-paracoccidioides
#17
REVIEW
Levi G Cleare, Daniel Zamith-Miranda, Joshua D Nosanchuk
Heat shock proteins (Hsps) are highly conserved biomolecules that are constitutively expressed and generally upregulated in response to various stress conditions (biotic and abiotic). Hsps have diverse functions, categorizations, and classifications. Their adaptive expression in fungi indicates their significance in these diverse species, particularly in dimorphic pathogens. Histoplasma capsulatum and Paracoccidioides species are dimorphic fungi that are the causative agents of histoplasmosis and paracoccidioidomycosis, respectively...
November 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28831671/opportunistic-invasive-mycoses-in-aids-cryptococcosis-histoplasmosis-coccidiodomycosis-and-talaromycosis
#18
REVIEW
Daniel B Chastain, Andrés F Henao-Martínez, Carlos Franco-Paredes
PURPOSE OF REVIEW: The goal of this review is to provide an update on the epidemiology, diagnosis, and treatment of opportunistic fungal infections in patients with human immunodeficiency virus (HIV) infection including Cryptococcus spp., Histoplasma spp., Coccidioides spp., and Talaromyces marneffei, formerly Penicillium marneffei. RECENT FINDINGS: In many settings, despite increasing roll out of antiretroviral therapy (ART), opportunistic invasive mycoses produce a substantial burden of disease...
August 22, 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/28822097/a-38-year-old-woman-with-necrotising-cervical-lymphadenitis-due-to-histoplasma-capsulatum
#19
Esther van de Vosse, Annelies van Wengen, Wendy F van der Meide, Leo G Visser, Jaap T van Dissel
CASE PRESENTATION: We analysed a 38-year-old woman with disseminated histoplasmosis for primary immunodeficiency. Her blood showed no IFN-γ response while her peripheral blood mononuclear cells (PBMCs) did. We identified IFN-γ autoantibodies of the IgG class in her serum. CONCLUSION: IFN-γ autoantibodies leading to infections were so far mainly detected in people from Asian descent, where it was found to be associated with certain HLA types. This may be the first patient of African descent, and without the typical HLA types that predispose to this problem, that produces IFN-γ autoantibodies...
August 18, 2017: Infection
https://www.readbyqxmd.com/read/28810039/distinguishing-white-dot-syndromes-with-patterns-of-choroidal-hypoperfusion-on-optical-coherence-tomography-angiography
#20
Jay C Wang, Inês Laíns, Lucia Sobrin, John B Miller
BACKGROUND AND OBJECTIVE: To compare patterns of choroidal hypoperfusion in white dot syndromes (WDS) using optical coherence tomography angiography (OCTA). PATIENTS AND METHODS: Consecutive patients with WDS were imaged with either the Zeiss AngioPlex OCT Angiography (Carl Zeiss AG, Oberkochen, Germany) or the AngioVue OCT Angiography (Optovue, Fremont, CA) from February to November 2016. Four patients with acute posterior multifocal placoid pigment epitheliopathy (APMPPE), birdshot chorioretinopathy (BCR), presumed ocular histoplasmosis syndrome (POHS), and multiple evanescent white dot syndrome (MEWDS) were selected...
August 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
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