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Quo vadis

C P Szabo, S Ramlall
The requirement of 'research completion' as necessary for specialist registration with the Health Professions Council of South Africa (HPCSA) has recently been subject to legal action, with a court order potentially shifting requirements beyond those envisaged by the HPCSA. The research requirement is congruent with National Department of Health strategy in this regard, i.e. the strengthening of research as a stated priority. While the expectation of research competency is not in itself contentious, the capacity of institutions and the ability of registrars to facilitate and complete, respectively, have brought the issue into focus...
December 1, 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
Mauricio Cortina
Although contemporary psychoanalysis is split into different schools and traditions, there is growing support for some of the main tenets of contemporary psychodynamic thinking from attachment theory, infant research, developmental psychopathology, new models of motivation, the neuroscience of emotions and emotional regulation, and the discovery of different implicit and explicit memory systems. These tenets, which psychodynamic clinicians of all stripes encounter in their daily work with clients, are the following: (1) that large footprints are left over from infancy and childhood which involved insensitive, intrusive, frightening, or shaming care; (2) the carryover of these relational experiences into adulthood are expressed as unconscious expectations and attributions we make of others (transference and countertransference; (3) defensive processes and emotional regulation and deregulatory patterns develop to cope with these unhealthy relations...
December 2016: Psychoanalytic Review
Ran Kornowski
No abstract text is available yet for this article.
November 15, 2016: Catheterization and Cardiovascular Interventions
Liran Levin
No abstract text is available yet for this article.
2016: Oral Health & Preventive Dentistry
Zsolt Matula, Gyöngyi Kudlik, Veronika Urbán S, Ferenc Uher
For decades, developing hematopoietic cells have been strictly compartmentalized into a small population of multipotent self-renewing hematopoietic stem cells, multipotent hematopoietic progenitor cells that are undergoing commitment to myeloid or lymphoid fates, and unipotent precursor cells that mature towards peripheral blood and immune cells. Recent studies, however, have provided a battery of findings that cannot be explained by this "classical" hierarchical model for the architecture of hematopoiesis...
November 2016: Orvosi Hetilap
Rupert Conrad
No abstract text is available yet for this article.
2016: Journal of Pain Research
Salvatore Brugaletta, Alberto Pernigotti
No abstract text is available yet for this article.
October 2016: Giornale Italiano di Cardiologia
(no author information available yet)
No abstract text is available yet for this article.
November 2016: Contact Dermatitis
Eric Ojerholm, Charles B Simone
No abstract text is available yet for this article.
September 7, 2016: Annals of Palliative Medicine
Thomas Hellmut Schindler
With the recent advent of PET/MRI scanners, the combination of molecular imaging with a variety of known and novel PET radiotracers, the high spatial resolution of MRI, and its potential for multi-parametric imaging are anticipated to increase the diagnostic accuracy in cardiovascular disease detection, while providing novel mechanistic insights into the initiation and progression of the disease state. For the time being, cardiac PET/MRI emerges as potential clinical tool in the identification and characterization of infiltrative cardiac diseases, such as sarcoidosis, acute or chronic myocarditis, and cardiac tumors, respectively...
September 22, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Roy W A Peake, Deborah L Marsden, Olaf A Bodamer, Michael H Gelb, David S Millington, Frits Wijburg
No abstract text is available yet for this article.
September 14, 2016: Clinical Chemistry
Philipp Kaldis
No abstract text is available yet for this article.
2016: Frontiers in Cell and Developmental Biology
J Döscher, C-J Busch, P J Schuler, S Laban
BACKGROUND: Immunotherapy remains a hot topic with an endless stream of new upcoming clinical trials. The results of studies to date are promising for second-line palliative treatment of head and neck squamous cell carcinoma (HNSCC). The next step is testing these strategies in randomized trials for first-line and curative treatment in an adjuvant, neoadjuvant, and primarily nonsurgical setting. So far, established biomarkers have not proven reliable enough to predict response rates precisely...
October 2016: HNO
L S Türkün, Ö Kanik
OBJECTIVE: The aim of this study was to evaluate the long-term clinical performance of two encapsulated glass ionomer cements (GICs) (EquiaFil and Riva SC) covered with two different coatings (Equia Coat and Fuji Varnish) over six years using modified US Public Health Service (USPHS) criteria. METHODS: Fifty-four patients having class I and II restorations/caries were included in the study. A total of 256 restorations were made with EquiaFil and Riva SC. Equia Coat or Fuji Varnish was used randomly on the surface of the restorations...
August 29, 2016: Operative Dentistry
László Solymosi
No abstract text is available yet for this article.
September 2016: Clinical Neuroradiology
Kristiina Tammimies, Terje Falck-Ytter, Sven Bölte
No abstract text is available yet for this article.
April 2016: Autism: the International Journal of Research and Practice
Jayoung Choi, Scott B Biering, Seungmin Hwang
Many intracellular pathogens survive and replicate within vacuole-like structures in the cytoplasm. It has been unclear how the host immune system controls such pathogen-containing vacuoles. Interferon-inducible GTPases are dynamin-like GTPases that target the membranes of pathogen-containing vacuoles. Upon their oligomerization on the membrane, the vacuole structure disintegrates and the pathogen gets exposed to the hostile cytoplasm. What has been obscure is how the immune system detects and directs the GTPases to these pathogen shelters...
July 18, 2016: Small GTPases
Terry M Peters, Cristian A Linte
Significant efforts have been dedicated to minimizing invasiveness associated with surgical interventions, most of which have been possible thanks to the developments in medical imaging, surgical navigation, visualization and display technologies. Image-guided interventions have promised to dramatically change the way therapies are delivered to many organs. However, in spite of the development of many sophisticated technologies over the past two decades, other than some isolated examples of successful implementations, minimally invasive therapy is far from enjoying the wide acceptance once envisioned...
October 2016: Medical Image Analysis
Javier A Menendez, Begoña Martin-Castillo, Jorge Joven
How many lives have already been saved by the anti-cancer drug metformin? Inadvertently perhaps, among the millions of type 2 diabetics with occult or known cancers and who have been prescribed metformin since the 1950s, thousands may have benefited from the anticancer properties of this first-line pharmacotherapy. Quo vadis? Now, researchers aim to move metformin from a non-targeted stage of cancer therapy that has been mostly developed retrospectively and empirically into a targeted therapy by following a biological rationale and a predefined mechanism of action...
June 23, 2016: Oncotarget
Francesca Muscente, Raffaele De Caterina
Cardiovascular disease (CVD) is still the leading cause of death worldwide. The overall growth of this epidemic during the last decade is largely because of the increasing incidence of CVD in low and middle-income countries, where inadequate health policies, poor availability, and lack of affordable medications, as well as poor patient adherence to treatment all limit the efficacy of cardiovascular prevention strategies. Complementary to a promotion of healthy lifestyles, a fixed dose combination or a 'polypill,' containing two or more drugs addressed at controlling various risk factors, might reduce costs and improve patient accessibility and adherence to treatment...
November 2016: Journal of Cardiovascular Medicine
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