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https://www.readbyqxmd.com/read/29429985/posterior-associative-and-cingulate-cortex-involvement-of-brain-single-photon-emission-computed-tomography-spect-imaging-in-semantic-dementia-with-probable-alzheimer-disease-pathology-a-case-report
#1
Yumi Takano, Keiko Kunitoki, Yasuko Tatewaki, Tatsushi Mutoh, Tomoko Totsune, Hideo Shimomura, Manabu Nakagawa, Hiroyuki Arai, Yasuyuki Taki
BACKGROUND Semantic dementia (SD) is a type of primary progressive aphasia with prominent language dysfunction, mostly within the spectrum of frontotemporal lobar degeneration (FTLD). Although there is an overlap in clinical manifestations of SD attributable to FTLD and neuropathologically proven Alzheimer disease (AD), clinical diagnostic clues are not readily available. We present a characteristic finding based on a single-photon emission computed tomography (SPECT)-based regional cerebral blood flow study and its statistical imaging analysis for a rare case of SD with AD-like pathology...
February 12, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29409154/anosognosia-in-mild-alzheimer-s-disease-is-correlated-with-not-only-neural-dysfunction-but-also-compensation
#2
Kenji Tagai, Shunichiro Shinagawa, Hidehiro Kada, Keisuke Inamura, Tomoyuki Nagata, Kazuhiko Nakayama
BACKGROUND: Anosognosia in Alzheimer's disease (AD) is a complicated, non-unitary phenomenon. In a clinical setting, patients with mild AD often preserve their awareness partially. We hypothesized that compensation, as well as neural dysfunction, could be correlated with anosognosia in mild AD. METHODS: The severity of anosognosia was evaluated using the Anosognosia Questionnaire for Dementia in 37 subjects with mild AD or mild cognitive impairment due to AD. The subjects also underwent single-photon emission computed tomography with N-isopropyl-p-[123 I]iodoamphetamine...
February 6, 2018: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/29406901/scan-without-evidence-of-dopaminergic-deficit-swedd-in-degenerative-parkinsonism-and-dementia-with-lewy-bodies-a-prospective-study
#3
Nicolas Nicastro, Pierre R Burkhard, Valentina Garibotto
BACKGROUND: 123I-FP-CIT SPECT imaging is a reliable method to assess presynaptic dopaminergic pathways in degenerative parkinsonisms and dementia with Lewy bodies (DLB). METHODS: We aimed at examining sensitivity of combined visual and semi-quantitative 123I-FP-CIT SPECT analyses in a prospective cohort of subjects with DLB and degenerative parkinsonisms - Parkinson's disease (PD), multiple system atrophy (MSA), corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP) to determine prevalence and clinical significance of scans without evidence of dopaminergic deficit (SWEDD)...
February 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29362011/neuropsychiatric-symptoms-and-cognitive-profile-in-mild-cognitive-impairment-with-lewy-bodies
#4
Paul C Donaghy, John-Paul Taylor, John T O'Brien, Nicola Barnett, Kirsty Olsen, Sean J Colloby, Jim Lloyd, George Petrides, Ian G McKeith, Alan J Thomas
BACKGROUND: The accurate clinical characterisation of mild cognitive impairment (MCI) is becoming increasingly important. The aim of this study was to compare the neuropsychiatric symptoms and cognitive profile of MCI with Lewy bodies (MCI-LB) with Alzheimer's disease MCI (MCI-AD). METHODS: Participants were ⩾60 years old with MCI. Each had a thorough clinical and neuropsychological assessment and 2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane single photon emission computed tomography FP-CIT SPECT)...
January 24, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29232183/loss-of-substantia-nigra-hyperintensity-at-3-0-t-mr-imaging-in-idiopathic-rem-sleep-behavior-disorder-comparison-with-123i-fp-cit-spect
#5
Yun Jung Bae, Jong-Min Kim, Kyeong Joon Kim, Eunhee Kim, Hyun Soo Park, Seo Young Kang, In-Young Yoon, Jee-Young Lee, Beomseok Jeon, Sang Eun Kim
Purpose To examine whether the loss of nigral hyperintensity (NH) on 3.0-T susceptibility-weighted (SW) magnetic resonance (MR) images can help identify high synucleinopathy risk in patients with idiopathic rapid eye movement sleep behavior disorder (iRBD). Materials and Methods Between March 2014 and April 2015, 18 consecutively recruited patients with iRBD were evaluated with 3.0-T SW imaging and iodine 123-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane (123I-FP-CIT) single photon emission computed tomography and compared with 18 healthy subjects and 18 patients with Parkinson disease (PD)...
December 12, 2017: Radiology
https://www.readbyqxmd.com/read/29212461/widespread-enlarged-perivascular-spaces-associated-with-dementia-and-focal-brain-dysfunction-case-report
#6
Daisuke Taniguchi, Hideki Shimura, Masao Watanabe, Nobutaka Hattori, Takao Urabe
BACKGROUND: Enlarged perivascular spaces (PVS) are common magnetic resonance imaging (MRI) findings, whereas widespread enlarged PVS are extremely rare. Although most patients with widespread enlarged PVS remain asymptomatic, some develop neurological dysfunctions; however, it remains unclear whether these are the consequence of widespread enlarged PVS. CASE PRESENTATION: A 64-year-old female patient developed consciousness disturbance, cognitive dysfunctions, fluent aphasia, agraphia, acalculia, and left-right disorientation after suffering from bronchopneumonia...
December 7, 2017: BMC Neurology
https://www.readbyqxmd.com/read/29199527/diversity-in-clinical-manifestations-and-imaging-features-of-neurosyphilis-obstacles-to-the-diagnosis-and-treatment-report-of-3-cases
#7
Hui Liu, Zong-Bo Zhao, Nian-Xing You
OBJECTIVE: To explore the clinical manifestations and imaging features of neurosyphilis and to discuss the obstacles in the diagnosis and treatment of neurosyphilis. METHODS: We present this case study involving 3 cases of definite neurosyphilis, focusing on their clinical data. RESULTS: Case 1 is a patient with numb and weak left lower limb. Case 2 showed slow reaction and dementia behaviors including worse memory and the decrease of calculation and orientation ability in this patient...
December 2, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29133699/referral-practice-reporting-standards-and-the-impact-of-dopamine-transporter-scans-done-in-a-tertiary-hospital
#8
Shakya Bhattacharjee, Albi J Chalissery, Tim Barry, Donagh O'Sullivan, Martin O'Connell, Timothy Lynch
AIMS: We studied the referral practice, reporting standards, and the impact of 123 ioflupane single photon emission computed tomogram dopamine transporters (DAT-SPECT) scans conducted for the diagnosis and clinical management of patients. SETTINGS AND DESIGNS: The present study was a retrospective, non-interventional study. MATERIALS AND METHODS: We assessed the DAT scan referral and the official reports available from the Nuclear Medicine Department of the Mater Misericordiae University Hospital over 1 year (2013)...
November 2017: Neurology India
https://www.readbyqxmd.com/read/29129545/predicting-progression-of-amnesic-mci-the-integration-of-episodic-memory-impairment-with-perfusion-spect
#9
Davide Quaranta, Guido Gainotti, Daniela Di Giuda, Maria Gabriella Vita, Fabrizio Cocciolillo, Giordano Lacidogna, Valeria Guglielmi, Carlo Masullo, Alessandro Giordano, Camillo Marra
The present study aimed at assessing if the ability to predict progression from amnesic Mild Cognitive Impairment (aMCI) to dementia is improved by considering the presence at the baseline of Single Photon Emission Computed Tomography (SPECT) perfusion abnormalities in addition to a defect of long term memory. The Episodic Memory Score (EMS), a global index which integrates results obtained in subtests of the Rey's Verbal Learning Test and the Rey-Osterrieth Figure recall, were taken into account to evaluate defects of long term memory...
October 24, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29116145/cingulate-island-sign-temporally-changes-in-dementia-with-lewy-bodies
#10
Tomomichi Iizuka, Rui Iizuka, Masashi Kameyama
The cingulate island sign (CIS) that reflects sparing of the posterior cingulate cortex (PCC) relative to the precuneus plus cuneus on FDG-PET and brain perfusion SPECT, has been proposed as a feature of dementia with Lewy bodies (DLB). As the CIS is influenced by concomitant Alzheimer's disease (AD)-type neurofibrillary tangle (NFT) pathology, we postulated that the CIS gradually disappears as DLB progresses. To determine temporal changes in the CIS, 24 patients with mild DLB and 7 with prodromal DLB underwent (123)I-IMP-SPECT and MMSE twice at an interval of two years...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29112909/potential-diagnostic-value-of-131i-mibg-myocardial-scintigraphy-in-discrimination-between-alzheimer-disease-and-dementia-with-lewy-bodies
#11
Mehrshad Abbasi, Nafise Ghalandari, Saeed Farzanefar, Vajiheh Aghamollaii, Mona Ahmadi, Morsaleh Ganji, Mohsen Afarideh, Sogol Loloee, Maryam Naseri, Abbas Tafakhori
OBJECTIVES: Clinical difficulty to discriminate between the Alzheimer disease (AD) and dementia with Lewy bodies (DLB) has led researchers to focus on highly sensitive functional imaging modalities. The aim of the present study was to assess 131I-MIBG cardiac imaging to distinguish between AD and DLB. PATIENTS AND METHODS: Seventeen patients who were known cases of dementia underwent 131I-MIBG myocardial scintigraphy to differentiate AD from DLB. Planar and 131I-MIBG SPECT were obtained 2h after the injection of 1mCi 131I-MIBG on a dual head gamma camera...
December 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29095328/c9orf72-intermediate-repeat-expansion-in-a-patient-with-psychiatric-disorders-and-progressive-cerebellar-ataxia
#12
Mario Meloni, Rita Farris, Paolo Solla, Marcello M Mascia, Francesco Marrosu, Antonino Cannas
INTRODUCTION: Large expansions of the noncoding GGGGCC repeat (more than 30) in the first intron of the C9ORF72 gene have been demonstrated to cause amyotrophic lateral sclerosis and frontotemporal dementia. Recent papers have investigated the possible pathogenic role and associated clinical phenotypes of hexanucleotide expansions with intermediate repeat lengths ranging between 20 and 29 repeats. CASE REPORT: We report a case of a 71-year-old Sardinian female patient with a long history of psychiatric disorders such as mixed anxiety-depressive disorder associated with somatization disorder and histrionic personality who developed a slowly progressive cerebellar syndrome, mild cognitive impairment, pyramidal signs, and rapid eye movement sleep behavior disorder with imaging abnormalities on the DaTSCAN single-photon emission computed tomography indicating an alteration in the presynaptic dopaminergic system...
November 2017: Neurologist
https://www.readbyqxmd.com/read/29093372/-development-of-spect-probes-for-in-vivo-imaging-of-%C3%AE-amyloid-and-tau-aggregates-in-the-alzheimer-s-disease-brain
#13
Hiroyuki Watanabe
 Alzheimer's disease (AD) is the most common form of irreversible dementia among elderly people. In the postmortem brains of AD patients, the deposition of senile plaques composed of β-amyloid (Aβ) peptides and neurofibrillary tangles composed of highly phosphorylated tau proteins are two neuropathological hallmarks. Therefore, the in vivo imaging of Aβ and tau aggregates with positron-emission tomography (PET) or single-photon emission computed tomography (SPECT) would promote drug development, early diagnosis, and monitoring of the disease status in AD patients...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/29072553/prospective-memory-impairment-in-idiopathic-rem-sleep-behavior-disorder
#14
Ondrej Bezdicek, Tomáš Nikolai, Jiří Nepožitek, Pavla Peřinová, David Kemlink, Pavel Dušek, Iva Příhodová, Simona Dostálová, Veronika Ibarburu, Jiří Trnka, Karel Kupka, Zuzana Mecková, Jiří Keller, Josef Vymazal, Evžen Růžička, Karel Šonka, Petr Dušek
OBJECTIVE: The aim of the present study was to investigate if prospective memory (PM) is impaired in idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD). RBD is a parasomnia characterized by dream enactment and by REM sleep without muscle atonia. iRBD is considered as the initial stage of neurodegeneration with pathological storage of alpha-synuclein. METHOD: Sixty iRBD patients with polysomnography-confirmed RBD without parkinsonism and dementia and 30 demographically matched normal controls (NC) were enrolled in the present study...
October 26, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28990131/diagnosis-and-management-of-cognitive-and-behavioral-changes-in-dementia-with-lewy-bodies
#15
REVIEW
Babak Tousi
Proper diagnosis of dementia with Lewy bodies (DLB) in clinical practice remains suboptimal as many cases are misdiagnosed, usually as Alzheimer disease (AD) or Parkinson's disease (PD) and, in rare cases, psychosis. Therefore, it is important for patients with dementia to be thoroughly evaluated by a specialist who is familiar with current diagnostic tests and treatment options. New diagnostic criteria from the Dementia with Lewy Bodies Consortium have been developed to increase diagnostic sensitivity for DLB (Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DLB Consortium; McKeith et al...
October 9, 2017: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/28969570/new-perspectives-of-alzheimer-disease-diagnosis-the-most-popular-and-future-methods
#16
Katarzyna Pietrzak, Kamila Czarnecka, Elżbieta M Ikiciuk-Olasik, Paweł Szymański
As lifespan tendency is increasing, age-related diseases are becoming a burden to the society and health care system. Mostly incurable, constitute a subject of researchers' work. In this review the insight into the problem of Alzheimer Disease (AD) diagnostics will be given. The unquestionable diagnosis is possible only during a post-mortem examination. AD is known as one of the forms of dementia and its differentiation from mild cognitive impairments has to be improved. Despite a great diagnostic progress during last decades, medicine still needs more accurate tools for an early detection of this incurable disease...
October 2, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28967811/clinical-findings-of-a-probable-case-of-mm2-cortical-type-sporadic-creutzfeldt-jakob-disease-with-antibodies-to-anti-n-terminus-of-%C3%AE-enolase
#17
Yuichi Hayashi, Megumi Yamada, Akio Kimura, Takahiko Asano, Katsuya Satoh, Tetsuyuki Kitamoto, Maokoto Yoneda, Takashi Inuzuka
We report the case of a 76-year-old woman presenting with 47-month history of progressive dementia and cortical blindness with no family history. Antibodies against thyroid glands and the N-terminus of α-enolase (NAE) were detected in her serum. Neurological examination revealed progressive dementia, frontal signs, visual disturbance, and exaggerated bilateral tendon reflexes in both legs. Diffusion MRI showed cortical hyper-intensities in the bilateral occipital and parietal, and the left frontal and temporal cortices...
October 2, 2017: Prion
https://www.readbyqxmd.com/read/28954753/dementia-with-lewy-bodies-presenting-as-probable-epileptic-seizure
#18
Mya Z Tun, Wee Kheng Soo, Kevin Wu, Richard Kane
We discuss the case of an 83-year-old man admitted to the hospital after losing control of his vehicle due to an unexplained episode of altered consciousness. This occurred on a background of multiple similar episodes associated with acute confusion, superimposed on a gradual cognitive decline spanning 6 years. Organic aetiologies for delirium were excluded and CT and MRI of the brain were negative for cerebrovascular accidents or other epileptogenic foci. Electroencephalogram (EEG) was negative for epileptiform activity...
September 27, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28938220/metabolic-correlate-of-memory-deficit-awareness-in-dementia-with-lewy-bodies-implication-in-cortical-midline-structure
#19
Tomomichi Iizuka, Masashi Kameyama
The neural substrate of memory-deficit awareness has been studied in mild cognitive impairment and Alzheimer's disease (AD). However, little is known about that in dementia with Lewy bodies (DLB). To determine the neural substrates of memory-deficit awareness in DLB, we investigated the relationship between awareness of memory-deficit and glucose metabolism in DLB. Thirty-four patients with DLB were assessed by 18 F-FDG-PET and dopamine transporter (DAT)-SPECT. The awareness was evaluated using an awareness index that represents the discrepancy between objective and subjective memory scores...
November 30, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28936173/combining-spect-and-quantitative-eeg-analysis-for-the-automated-differential-diagnosis-of-disorders-with-amnestic-symptoms
#20
Yvonne Höller, Arne C Bathke, Andreas Uhl, Nicolas Strobl, Adelheid Lang, Jürgen Bergmann, Raffaele Nardone, Fabio Rossini, Harald Zauner, Margarita Kirschner, Amirhossein Jahanbekam, Eugen Trinka, Wolfgang Staffen
Single photon emission computed tomography (SPECT) and Electroencephalography (EEG) have become established tools in routine diagnostics of dementia. We aimed to increase the diagnostic power by combining quantitative markers from SPECT and EEG for differential diagnosis of disorders with amnestic symptoms. We hypothesize that the combination of SPECT with measures of interaction (connectivity) in the EEG yields higher diagnostic accuracy than the single modalities. We examined 39 patients with Alzheimer's dementia (AD), 69 patients with depressive cognitive impairment (DCI), 71 patients with amnestic mild cognitive impairment (aMCI), and 41 patients with amnestic subjective cognitive complaints (aSCC)...
2017: Frontiers in Aging Neuroscience
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