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https://www.readbyqxmd.com/read/27897064/diagnosis-of-dementia-with-lewy-bodies-can-123-i-imp-and-123-i-mibg-scintigraphy-yield-new-core-features
#1
Fumi Sakamoto, Shinya Shiraishi, Noriko Tsuda, Mamoru Hashimoto, Seiji Tomiguchi, Manabu Ikeda, Yasuyuki Yamashita
OBJECTIVE: Since the clinical symptoms of different types of dementia frequently overlap, especially in the earlier stages at onset, it is difficult to distinguish dementias with Lewy bodies (DLB) from other neurodegenerative dementias based on their clinical manifestations alone. Nuclear medicine imaging has been reported as a high-value index for the objective evaluation and diagnosis of DLB. The aim of this study was to evaluate whether nuclear medicine imaging findings may yield core features to be added to the diagnosis of DLB...
November 29, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27886010/discriminative-properties-of-hippocampal-hypoperfusion-in-marijuana-users-compared-to-healthy-controls-implications%C3%A2-for-marijuana-administration%C3%A2-in%C3%A2-alzheimer-s-dementia
#2
Daniel G Amen, Borhan Darmal, Cyrus A Raji, Weining Bao, Lantie Jorandby, Somayeh Meysami, Cauligi S Raghavendra
BACKGROUND: Few studies have evaluated the impact of marijuana use on regional cerebral blood flow. OBJECTIVE: To determine whether perfusion in specific brain regions on functional neuroimaging, including those affected by Alzheimer's disease pathology, are abnormal in marijuana users compared to controls. METHOD: Persons with a diagnosis of cannabis use disorder by DSM-IV and DSM-V criteria (n = 982) were compared to controls (n = 92) with perfusion neuroimaging with SPECT at rest and at a concentration task...
November 24, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27866729/molecular-imaging-in-the-diagnosis-of-alzheimer-s-disease-and-related-disorders
#3
REVIEW
L Koric, E Guedj, M O Habert, F Semah, P Branger, P Payoux, F Le Jeune
INTRODUCTION: The diagnosis of Alzheimer's disease (AD) and its related disorders rely on clinical criteria. There is, however, a large clinical overlap between the different neurodegenerative diseases affecting cognition and, frequently, there are diagnostic uncertainties with atypical clinical presentations. Current clinical practices can now regularly use positron emission tomography (PET) and single-photon emission computed tomography (SPECT) molecular imaging to help resolve such uncertainties...
November 17, 2016: Revue Neurologique
https://www.readbyqxmd.com/read/27858707/neural-basis-of-apathy-in-patients-with-amnestic-mild-cognitive-impairment
#4
Hiroaki Kazui, Ryuichi Takahashi, Yuki Yamamoto, Kenji Yoshiyama, Hideki Kanemoto, Yukiko Suzuki, Shunsuke Sato, Shingo Azuma, Takashi Suehiro, Eku Shimosegawa, Kazunari Ishii, Toshihisa Tanaka
BACKGROUND: Although apathy is associated with damage to the frontal and temporal lobes in Alzheimer's disease (AD), the crucial regions for apathy in patients with amnestic mild cognitive impairment (aMCI) are unknown. OBJECTIVE: To identify brain regions associated with apathy in aMCI patients. METHODS: The subjects of this study were 98 aMCI patients who were entered in our dementia registry between March 1, 2009 and April 30, 2015 and who satisfied our criteria for aMCI...
November 14, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27844089/-biomarkers-for-dementia-and-other-neurodegenerative-diseases-current-developments
#5
J Wiltfang, P Lewczuk, M Otto
Cerebrospinal fluid-based neurochemical dementia diagnostics (CSF-NDD) support the early and differential diagnosis of dementia, most importantly the diagnosis of early or preclinical Alzheimer's dementia (AD). Meanwhile CSF-NDD are now recommended for improved exclusion and positive diagnostics of AD by the German national neuropsychiatry S3 dementia guidelines ( www.DGPPN.de ). Meta-analyses of independent international multicenter studies have shown that a combined CSF analysis of amyloid-beta 1-42 (Aβ 1-42, decreased), total tau proteins (increased) and phospho-tau proteins (increased) offers a sensitivity and specificity of 80-90 % for the early and differential diagnosis of AD (AD versus all other)...
November 14, 2016: Der Nervenarzt
https://www.readbyqxmd.com/read/27774875/brain-spect-with-perfusion-radiopharmaceuticals-and-dopaminergic-system-radiocompounds-in-dementia-disorders
#6
Susanna Nuvoli, Angela Spanu, Giuseppe Madeddu
As well known, the increase in life expectancy and the better physical condition of people in western countries will lead in the next 20 years to a dramatic development of neurodegenerative diseases, especially of dementia that could be considered one of the most important problems in clinical, social and economic fields for the future. Therefore, the differential diagnosis of the various types of dementia is a critical step for patients, clinicians and researchers since an accurate "in vivo" diagnosis can lead to a better patients management...
October 19, 2016: Current Alzheimer Research
https://www.readbyqxmd.com/read/27772745/preserved-regional-cerebral-blood-flow-in-the-occipital-cortices-brainstem-and-cerebellum-of-patients-with-v180i-129m-genetic-creutzfeldt-jakob-disease-in-serial-spect-studies
#7
Yuichi Hayashi, Nobuaki Yoshikura, Akira Takekoshi, Megumi Yamada, Takahiko Asano, Akio Kimura, Katsuya Satoh, Tetsuyuki Kitamoto, Takashi Inuzuka
Creutzfeldt-Jakob disease (CJD) with a causative point mutation of valine to isoleucine at codon 180 (V180I) is one of the major types of genetic CJD (gCJD) in Japan. V180I gCJD is rarely accompanied by a family history, and its clinical characteristics include late-onset, long disease duration, and edematous cortical hyperintensity in diffusion, fluid attenuate inversion and T2-weighted MRI. We performed serial imaging with single-photon emission computed tomography (SPECT) and MRI in three V180I gCJD cases over long-term observation...
November 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27755933/psychoradiology-the-frontier-of-neuroimaging-in-psychiatry
#8
Su Lui, Xiaohong Joe Zhou, John A Sweeney, Qiyong Gong
Unlike neurologic conditions, such as brain tumors, dementia, and stroke, the neural mechanisms for all psychiatric disorders remain unclear. A large body of research obtained with structural and functional magnetic resonance imaging, positron emission tomography/single photon emission computed tomography, and optical imaging has demonstrated regional and illness-specific brain changes at the onset of psychiatric disorders and in individuals at risk for such disorders. Many studies have shown that psychiatric medications induce specific measurable changes in brain anatomy and function that are related to clinical outcomes...
November 2016: Radiology
https://www.readbyqxmd.com/read/27740992/positron-emission-tomography-and-single-photon-emission-computed-tomography-in-neurology
#9
Robert S Miletich
PURPOSE OF REVIEW: Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are now available for routine clinical applications in neurology. This article discusses their diagnostic use in dementia, brain tumors, epilepsy, parkinsonism, cerebrovascular disease, and traumatic brain injury. RECENT FINDINGS: Neuromolecular imaging, also known as nuclear neurology, involves clinical imaging of both basal regional physiology (perfusion, metabolism, and transport mechanisms) and specific neurochemical physiology (currently, only the dopamine transporter)...
October 2016: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/27640073/positive-affect-and-regional-cerebral-blood-flow-in-alzheimer-s-disease
#10
Satoshi Hayashi, Seishi Terada, Shuhei Sato, Etsuko Oshima, Tomoko Miki, Osamu Yokota, Takeshi Ishihara, Norihito Yamada
Quality of life (QOL) has been recently recognized as the central purpose of healthcare, and positive affect is one of the core dimension of QOL. However, positive affect among patients with dementia or Alzheimer's disease (AD) has not received much attention in the medical research field. One hundred sixteen consecutive patients with AD were recruited from the outpatient units of the Memory Clinic of Okayama University Hospital. The positive affect score was evaluated using the positive affect domain of the Quality of Life questionnaire for Dementia (QOL-D)...
October 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27628070/clinical-heterogeneity-of-lrrk2-p-i2012t-mutation
#11
Tian-Sin Fan, Ruey-Meei Wu, Pei-Lung Chen, Ta-Fu Chen, Huei-Ying Li, Yin-Hung Lin, Chien-Yu Chen, Meng-Ling Chen, Chun-Hwei Tai, Hang-I Lin, Chin-Hsien Lin
INTRODUCTION: Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease (PD). However, only few cases carrying LRRK2 mutations have been reported in Taiwanese PD patients. METHODS: We used targeted next generation sequencing (NGS), covering 24 candidate genes involved in neurodegenerative disorders, to analyze 40 probands with familial PD, and 10 patients with mixed neurodegenerative disorders. Sanger sequencing of the identified mutation in the first set of the study was performed in additional 270 PD patients, including 139 familial PD and 131 early-onset PD (onset age less than 50 years old), and 300 age/gender matched control subjects...
September 7, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27624723/the-italian-dementia-with-lewy-bodies-study-group-dlb-sindem-toward-a-standardization-of-clinical-procedures-and-multicenter-cohort-studies-design
#12
L Bonanni, A Cagnin, F Agosta, C Babiloni, B Borroni, M Bozzali, A C Bruni, M Filippi, D Galimberti, R Monastero, C Muscio, L Parnetti, D Perani, L Serra, V Silani, P Tiraboschi, A Padovani
Dementia with Lewy bodies (DLB) causes elevated outlays for the National Health Systems due to high institutionalization rate and patients' reduced quality of life and high mortality. Furthermore, DLB is often misdiagnosed as Alzheimer's disease. These data motivate harmonized multicenter longitudinal cohort studies to improve clinical management and therapy monitoring. The Italian DLB study group of the Italian Neurological Society for dementia (SINdem) developed and emailed a semi-structured questionnaire to 572 national dementia centers (from primary to tertiary) to prepare an Italian large longitudinal cohort...
September 13, 2016: Neurological Sciences
https://www.readbyqxmd.com/read/27620458/the-cingulate-island-sign-within-early-alzheimer-s-disease-specific-hypoperfusion-volumes-of-interest-is-useful-for-differentiating-alzheimer-s-disease-from-dementia-with-lewy-bodies
#13
Etsuko Imabayashi, Kota Yokoyama, Tadashi Tsukamoto, Daichi Sone, Kaoru Sumida, Yukio Kimura, Noriko Sato, Miho Murata, Hiroshi Matsuda
BACKGROUND: In addition to occipital hypoperfusion, preserved metabolism of the posterior cingulate gyri (PCG) relative to the precunei is known as the cingulate island sign (CIS) in the patients with dementia with Lewy bodies (DLB). CIS has been detected using [(18)F]fluorodeoxyglucose positron emission tomography but not using brain perfusion single-photon emission computed tomography (SPECT). The purpose of this study was to optimize brain perfusion SPECT to enable differentiation of DLB from Alzheimer's disease (AD) using CIS and occipital hypoperfusion...
December 2016: EJNMMI Research
https://www.readbyqxmd.com/read/27540431/brain-18-f-fdg-18-f-florbetaben-pet-ct-123-i-fp-cit-spect-and-cardiac-123-i-mibg-imaging-for-diagnosis-of-a-cerebral-type-of-lewy-body-disease
#14
Axel Van Der Gucht, Laurent Cleret de Langavant, Ophélie Bélissant, Corentin Rabu, Anne-Ségolène Cottereau, Eva Evangelista, Julia Chalaye, Sophie Bonnot-Lours, Gilles Fénelon, Emmanuel Itti
A 67-year-old man was referred for fluctuating neuropsychiatric symptoms, featuring depression, delirious episodes, recurrent visual hallucinations and catatonic syndrome associated with cognitive decline. No parkinsonism was found clinically even under neuroleptic treatment. (18)F-FDG PET/CT showed hypometabolism in the posterior associative cortex including the occipital cortex, suggesting Lewy body dementia, but (123)I-FP-CIT SPECT was normal and cardiac (123)I-MIBG imaging showed no signs of sympathetic denervation...
September 2016: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27530773/longitudinal-imaging-of-the-ageing-mouse
#15
E Dall'Ara, M Boudiffa, C Taylor, D Schug, E Fiegle, A J Kennerley, C Damianou, G M Tozer, F Kiessling, R Müller
Several non-invasive imaging techniques are used to investigate the effect of pathologies and treatments over time in mouse models. Each preclinical in vivo technique provides longitudinal and quantitative measurements of changes in tissues and organs, which are fundamental for the evaluation of alterations in phenotype due to pathologies, interventions and treatments. However, it is still unclear how these imaging modalities can be used to study ageing with mice models. Almost all age related pathologies in mice such as osteoporosis, arthritis, diabetes, cancer, thrombi, dementia, to name a few, can be imaged in vivo by at least one longitudinal imaging modality...
August 13, 2016: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/27511183/evolution-of-clinical-features-in-possible-dlb-depending-on-fp-cit-spect-result
#16
Zuzana Walker, Emilio Moreno, Alan Thomas, Fraser Inglis, Naji Tabet, Tim Stevens, Tim Whitfield, Dag Aarsland, Michael Rainer, Alessandro Padovani
OBJECTIVE: To test the hypothesis that core and suggestive features in possible dementia with Lewy bodies (DLB) would vary in their ability to predict an abnormal dopamine transporter scan and therefore a follow-up diagnosis of probable DLB. A further objective was to assess the evolution of core and suggestive features in patients with possible DLB over time depending on the (123)I-FP-CIT SPECT scan result. METHODS: A total of 187 patients with possible DLB (dementia plus one core or one suggestive feature) were randomized to have dopamine transporter imaging or to follow-up without scan...
September 6, 2016: Neurology
https://www.readbyqxmd.com/read/27484407/bupropion-improved-apathy-in-behavioral-variant-frontotemporal-dementia-a-case-report
#17
Chia-Pei Lin, Chih-Pang Chu, Hsing-Cheng Liu
Apathy is a common neurobehavioral sign in cases of behavioral variant frontotemporal dementia. However, there is still no established sustained effective treatment. We present the case of a 65-year-old man with behavioral variant frontotemporal dementia who suffered from severe apathy, but his apathy improved after a 10-month period of bupropion treatment. His single photon emission computed tomography report also showed slight improvement. To the best of our knowledge, such a case with imaging evidence has never been reported...
October 2016: Neurocase
https://www.readbyqxmd.com/read/27469360/123i-iodobenzovesamicol-spect-imaging-of-cholinergic-systems-in-dementia-with-lewy-bodies
#18
Joachim Mazère, Frederic Lamare, Philippe Fernandez, Michèle Allard, Willy Mayo
: Cholinergic alterations in Dementia with Lewy bodies (DLB) are widely documented in post mortem studies whereas in vivo studies are sparse, particularly at subcortical level. We used (123)I-iodobenzovesamicol, a single Photon Emission Computed Tomography (SPECT) radiotracer of the Vesicular Acetylcholine Transporter (VAChT), to evaluate in vivo in DLB the integrity of the three main cholinergic pathways: the Ch1 (septo-hippocampal), the Ch4 (innominato-cortical) and the Ch5 (ponto-thalamic) cholinergic pathways, as well as the striatal cholinergic interneurons...
July 28, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27462146/electroencephalography-driven-approach-to-prodromal-alzheimer-s-disease-diagnosis-from-biomarker-integration-to-network-level-comprehension
#19
Davide Vito Moretti
Decay of the temporoparietal cortex is associated with prodromal Alzheimer's disease (AD). Additionally, shrinkage of the temporoparietal cerebral area has been connected with an increase in α3/α2 electroencephalogram (EEG) power ratio in prodromal AD. Furthermore, a lower regional blood perfusion has been exhibited in patients with a higher α3/α2 proportion when contrasted with low α3/α2 proportion. Furthermore, a lower regional blood perfusion and reduced hippocampal volume has been exhibited in patients with higher α3/α2 when contrasted with lower α3/α2 EEG power ratio...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27432669/single-photon-emission-tomography
#20
Karolien Goffin, Koen van Laere
Single-photon emission computed tomography (SPECT) is a functional nuclear imaging technique that allows visualization and quantification of different in vivo physiologic and pathologic features of brain neurobiology. It has been used for many years in diagnosis of several neurologic and psychiatric disorders. In this chapter, we discuss the current state-of-the-art of SPECT imaging of brain perfusion and dopamine transporter (DAT) imaging. Brain perfusion SPECT imaging plays an important role in the localization of the seizure onset zone in patients with refractory epilepsy...
2016: Handbook of Clinical Neurology
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