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https://www.readbyqxmd.com/read/26165047/relationship-of-hepatotoxicity-and-the-target-tissue-dose-of-decabrominated-diphenyl-ether-in-subacutely-exposed-wistar-rats
#1
Marijana Ćurčić, Sladjana Tanasković, Sanja Stanković, Saša Janković, Marko Antunović, Snežana Djordjević, Vesna Kilibarda, Slavica Vučnić, Biljana Antonijević
BACKGROUND/AIM: Based on numerous studies in animals, the most prominent toxic effects of decabrominated diphenyl ether (BDE-209) are observed in the liver, thyroid hormone homeostasis, reproductive and nervous systems. BDE-209 exhibits its toxic effects partly through the aryl hydrocarbon (Ah) receptor and consequent induction of hepatic microsomal enzymes. The aim of this study was to assess the hepatotoxic effect vs target tissue dose of BDE-209 in the subacutely orally exposed Wistar rats...
May 2015: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
https://www.readbyqxmd.com/read/21594376/identification-of-exons-in-a-novel-embryonal-carcinoma-locus-using-the-grail-program
#2
R Gama, Y Du, J Bauman, P McCormick
Embryonal carcinoma (EC) cells have proven to be of particular value in studies of both oncogenesis and mammalian development, as well as in evaluating the relationship between these two phenomena. Infection of the EC cell line, NR1-0, with a defective retrovirus containing a neomycin resistance cassette (Neo(r)), produced a mutant cell line: NR1-6. Genetic analysis of this variant cell line indicates that there is only a single insertion site. Interestingly, however, the NR1-6 cell line is unique in its morphology, tumorigenicity, and differentiative potential (1)...
March 1996: Oncology Reports
https://www.readbyqxmd.com/read/21594338/novel-mouse-repetitive-element-structures-in-an-embryonal-carcinoma-mutant-cell-line
#3
R Gama, Y Du, J Bauman, T Chan, P McCormick
A mutant embryonal carcinoma (EC) cell line, NR1-6, has been isolated subsequent to infection with a retroviral insert containing a neomycin resistance cassette (Neo(r)) (1). This variant cell line has only a single insertion site, but is unique in its morphology, tumorigenicity, and differentiative potential (2). In order to understand the exact nature of the mutational event, we have sequenced the regions immediately flanking the insertion site (encompassing over 18 kb). Searches for homology in GenBank using the GCG and Blast programs have revealed homology to only a few small conserved regions (4 B1 repetitive elements approximately 150 bp long and a CA/GT dinucleotide repeat)...
January 1996: Oncology Reports
https://www.readbyqxmd.com/read/17974439/-biochemistry-in-liver-cancer
#4
N Kostić, J Dzelebdzić, D Miljković, Z Isajlović
In a group of patients (n=18) with primary (n=7) liver cancer high increase in enzyme activities (AST, ALT, AP, gama-GT, 5'NU), billirubin, alpha-1 AT, alpha- and beta-globulins and alpha-phetoprotein, and considerable decrease of albumin and cholinesterase, were established. These disturbances were duo to the weakened biofunction of the liver. All the examined biochemical parameters are of great significance in the differential diagnosis of cancer, prognosis and development of the disease.
September 1995: Srpski Arhiv za Celokupno Lekarstvo
https://www.readbyqxmd.com/read/17625661/obstructive-jaundice-induces-early-depression-of-mitochondrial-respiration-in-rat-hepatocytes
#5
Riad Naim Younes, Renato Sergio Poggetti, Belchor Fontes, Mario Matsuo Itinoshe, Vanda Mitie Yoshida, Maria Elisa A Carvalho, Dario Birolini
INTRODUCTION: Oxidative phosphorylation dysfunction of hepatocyte mitochondria is involved in the pathophysiology of organ dysfunction following obstructive jaundice (OJ). However the time period from biliary occlusion to the occurrence of the dysfunction has not been determined decisively. PURPOSE: To evaluate the early effects (1 d and 7 d) of OJ on liver mitochondria respiratory function in rats. METHODS: Male Wistar rats (200-250 g) were randomly divided into the following 3 groups: laparotomy plus OJ for 24 h (1d group) (n = 10); laparotomy plus OJ for 7 d (7d group) (n = 10); sham control procedure (CTR group) (n = 12)...
July 2007: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/11230964/amniocentesis-and-biochemical-evaluation-of-amniotic-fluid-in-ewes-at-70-100-and-145-days-of-pregnancy
#6
N C. Prestes, M C.L. Chalhoub, M D. Lopes, R K. Takahira
The objectives of this study were to determine the technical viability of amniocentesis in sheep and to observe biochemical changes in the amniotic fluid components. Amniotic fluid samples were collected by puncture in the greatest curvature of the uterine horn at days 70, 100, and 145 of pregnancy. The surgical procedure for collection of amniotic fluid samples was safe and efficient. For three stages of pregnancy, the following results were obtained: pH values 8.36, 7.34 and 7.37; glucose concentrations, 16...
March 2001: Small Ruminant Research: the Journal of the International Goat Association
https://www.readbyqxmd.com/read/9005696/-prevalence-of-chronic-hepatic-disease-in-portugal-apropos-of-a-review-carried-out-in-a-hepatology-unit
#7
A I Valente, A Almeida, A Gouveia, F Serejo, F Ramalho, A Baptista, A Saragoça, M C Moura
UNLABELLED: The chronic elevation of Aminotransferases is one of the most frequent indications for percutaneous Liver Biopsy (LB). From a retrospective study of LB performed in the Hepatology liver Unit of Santa Maria Hospital, between 1989 and 1993, we correlated the histologic diagnosis with the etiology of liver disease, sex, age and the Aspartate aminotransferase/Alanine aminotransferase (AST/ALT) and Gama-Glutamyl transpeptidase (gamma GT) index in patients with chronic liver test abnormalities...
July 1996: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/2618802/-alcoholism-in-an-industrial-population-diagnosis-prevalence-and-conditioning-factors
#8
P Fidalgo, M P Alves, A Freire, F Batista, A Fernandes, B Gard, F B Barros, J P Correia
The pattern of alcohol consumption has been studied among 92 males, workers in a factory of the Lisbon area. In this population there were three groups of ethanol consumers: I--non consumers, 6%; II--medium, up to 80g/day, 68%; III--heavy consumers, more than 80g/day, 26%. Another group (IV) was considered, for reference, with 23 patients with heavy alcoholism in the outpatients of an alcoholic addicts clinic. Besides the clinical questionnaire and medical examination, the following methods have been used and analysed: brief MAST; Le Gô, Mean Corpuscular Volume (MCV), serum glutamic oxalacetic Trasaminase (SGOT), and gama-glutamyl transpepticlase (gamma GT)...
March 1989: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/1350699/-gamma-glutamyltransferase-and-alcoholic-hepatic-disease
#9
COMPARATIVE STUDY
P Andrade, M L Rocha, C Sofia, M L Pragana, M R Oliveira, F Portela, G Monteiro
Accepting the principle that Gama-gt values are elevated in alcoholic patients, the authors attempted to find out if that enzyme might be helpful in distinguishing alcoholics with or without hepatic morphologic lesion. 110 alcoholic patients with and 57 without histologically proved hepatic lesion were studied. The authors conclude that a single determination of Gama-gt lacks specificity to detect, among the alcoholic individuals, those who already carry a morphologic, nonreversible lesion.
March 1992: Acta Médica Portuguesa
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