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Rosuvastatin

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https://www.readbyqxmd.com/read/28812116/slco1b1-521t%C3%A2-%C3%A2-c-polymorphism-associated-with-rosuvastatin-induced-myotoxicity-in-chinese-coronary-artery-disease-patients-a-nested-case-control-study
#1
Ju-E Liu, Xiao-Ying Liu, Sheng Chen, Yan Zhang, Li-Yun Cai, Min Yang, Wei-Hua Lai, Bin Ren, Shi-Long Zhong
PURPOSE: This nested case-control study aimed to evaluate the association of candidate genetic variants with statin-induced myotoxicity in Chinese patients with coronary artery disease (CAD). METHODS: One hundred forty-eight Chinese patients experiencing statin-induced myotoxicity were included in our study, and 255 patients without muscular side effects served as controls. Five SNPs in CYP3A5, SLCO1B1, and APOE were genotyped. The effect of genetic variants on statin-induced myotoxicity was assessed...
August 15, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28808886/assessment-of-pharmacokinetic-interactions-between-obeticholic-acid-and-caffeine-midazolam-warfarin-dextromethorphan-omeprazole-rosuvastatin-and-digoxin-in-phase-1-studies-in-healthy-subjects
#2
Jeffrey E Edwards, Lise Eliot, Andrew Parkinson, Sharon Karan, Leigh MacConell
INTRODUCTION: Obeticholic acid (OCA), a potent and selective farnesoid X receptor agonist, is indicated for the treatment of primary biliary cholangitis (PBC). We investigated the potential drug-drug interaction effect of OCA on metabolic CYP450 enzymes and drug transporters. METHODS: Five phase 1 single-center, open-label, fixed-sequence, inpatient studies were conducted in healthy adult subjects to evaluate the effect of oral daily doses of 10 or 25 mg OCA on single-dose plasma pharmacokinetics of specific probe substrates for enzymes CYP1A2 (caffeine, R-warfarin), CYP3A (midazolam, R-warfarin), CYP2C9 (S-warfarin), CYP2D6 (dextromethorphan), CYP2C19 (omeprazole), and drug transporters, BCRP/OATP1B1/OATP1B3 (rosuvastatin), and P-gp (digoxin)...
August 14, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28807393/treatment-trends-effectiveness-and-safety-of-statins-on-lipid-goal-attainment-in-chinese-percutaneous-coronary-intervention-patients-a-multicenter-retrospective-cohort-study
#3
Yundai Chen, Dandan Li, Jing Jing, Hongbing Yan, Jinghua Liu, Zhujun Shen, Stefan James, Christoph Varenhorst
PURPOSE: Limited data exist on the use of statins in Chinese patients with coronary artery disease (CAD) treated with percutaneous coronary intervention (PCI). We therefore conducted this study to observe the usage trend and the effectiveness of statins on LDL-C goal attainment and other lipid parameters among PCI-treated patients. METHODS: This multicenter, retrospective, observational, longitudinal cohort study was conducted in PCI-treated patients with CAD between July 1, 2011, and February 28, 2015...
August 11, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28803122/comparison-of-pharmacokinetics-and-safety-of-a-fixed-dose-combination-of-rosuvastatin-and-ezetimibe-versus-separate-tablets-in-healthy-subjects
#4
Kyoung Lok Min, Min Soo Park, Jina Jung, Min Jung Chang, Choon Ok Kim
PURPOSE: Rosuvastatin and ezetimibe are concomitantly used for dyslipidemia treatment. Compared with separate tablets, fixed-dose combination (FDC) tablets of rosuvastatin/ezetimibe could increase patient compliance. The aim of this study was to compare the pharmacokinetic (PK) profiles of an FDC tablet of rosuvastatin/ezetimibe and co-administration of rosuvastatin and ezetimibe as separate tablets in healthy Korean volunteers. METHODS: This trial was a randomized, open-label, single-dose, 2-way crossover study...
August 9, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28801030/lipoprotein-a-screening-in-patients-with-controlled-traditional-risk-factors-undergoing-percutaneous-coronary-intervention
#5
Matthew C Weiss, Jeffrey S Berger, Eugenia Gianos, Edward Fisher, Arthur Schwartzbard, James Underberg, Howard Weintraub
BACKGROUND: Lipoprotein(a) [Lp(a)] is an inherited atherogenic lipoprotein and an independent risk factor for atherosclerotic cardiovascular disease; however, its clinical role remains limited. OBJECTIVE: We hypothesized that Lp(a) screening in high cardiovascular risk patients could provide insight into disease pathogenesis and modify physician behavior for treatment intensification targeting traditional risk factors when Lp(a)-related risk was identified. METHODS: We screened 113 patients presenting electively for percutaneous coronary intervention (PCI) for Lp(a) who met any of the following criteria: (1) premature coronary artery disease (male age <55 years, female age <65 years); (2) family history of premature coronary artery disease; (3) progression to PCI despite well-controlled traditional risk factors (blood pressure <140/90 mm Hg, and low-density lipoprotein cholesterol <100 mg/dL, and HbA1c <7%, and nonsmoker); or (4) progression to PCI despite at least moderate intensity statin use (simvastatin 40, atorvastatin 40-80, or rosuvastatin 20-40 mg daily)...
July 22, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28793863/cardiovascular-risk-and-dyslipidemia-among-persons-living-with-hiv-a-review
#6
REVIEW
Paolo Maggi, Antonio Di Biagio, Stefano Rusconi, Stefania Cicalini, Maurizio D'Abbraccio, Gabriella d'Ettorre, Canio Martinelli, Giuseppe Nunnari, Laura Sighinolfi, Vincenzo Spagnuolo, Nicola Squillace
BACKGROUND: Aim of this review is to focus the attention on people living with HIV infection at risk of developing a cardiovascular event. What is or what would be the most suitable antiretroviral therapy? Which statin or fibrate to reduce the risk? How to influence behavior and lifestyles? DISCUSSION: Prevention of cardiovascular disease (CVD) risk remains the first and essential step in a medical intervention on these patients. The lifestyle modification, including smoking cessation, increased physical activity, weight reduction, and the education on healthy dietary practices are the main instruments...
August 9, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28790154/ckm-glu83gly-is-associated-with-blunted-creatine-kinase-variation-but-not-with-myalgia
#7
Moneeza Kalhan Siddiqui, Abirami Veluchamy, Cyrielle Maroteau, Roger Tavendale, Fiona Carr, Ewan Pearson, Helen Colhoun, Andrew D Morris, Jacob George, Alexander Doney, Munir Pirmohamed, Ana Alfirevic, Mia Wadelius, Anke H Maitland van der Zee, Paul M Ridker, Daniel I Chasman, Colin N A Palmer
BACKGROUND: To test the association of a recently reported variant in the creatine kinase (CK) muscle gene, CKM Glu83Gly (rs11559024) with constitutive creatine phosphokinase (CK) levels, CK variation, and inducibility. Given the diagnostic importance of CK in determining muscle damage, we tested the association of the variant with myalgia. METHODS AND RESULTS: Meta-analysis between longitudinal cohort GoDARTS (Genetics of Diabetes Audit and Research, Tayside Scotland), minor allele frequency (=0...
August 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28774497/activity-of-rosuvastatin-in-tachyzoites-of-toxoplasma-gondii-rh-strain-in-hela-cells
#8
Raquel Arruda Sanfelice, Laís Fernanda Machado, Larissa Rodrigues Bosqui, Milena Menegazzo Miranda-Sapla, Fernanda Tomiotto-Pellissier, Gabriela de Alcântara Dalevedo, Dielle Ioris, Guilherme Fonseca Reis, Luciano Aparecido Panagio, Italmar Teodorico Navarro, Juliano Bordignon, Ivete Conchon-Costa, Wander Rogério Pavanelli, Ricardo Sergio Almeida, Idessania Nazareth Costa
Due to the toxicity of conventional medication in toxoplasmosis, some drugs are being studied for treating this infection, such as statins, especially rosuvastatin compound, which is efficient in inhibiting the initial isoprenoid biosynthesis processes in humans and the parasite. The goal of this study was to assess the activity of rosuvastatin in HeLa cells infected with the RH strain of T. gondii. In the experiment, HeLa cells (1 × 10(5)) were infected with tachyzoites of T. gondii (5 × 10(5)). After the experimental infection, we assessed the number of infected cells and the amount of intracellular tachyzoites...
August 1, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28765529/intracoronary-imaging-cholesterol-efflux-and-transcriptomics-after-intensive-statin-treatment-in-diabetes
#9
Surbhi Chamaria, Kipp W Johnson, Yuliya Vengrenyuk, Usman Baber, Khader Shameer, Aparna A Divaraniya, Benjamin S Glicksberg, Li Li, Samit Bhatheja, Pedro Moreno, Akiko Maehara, Roxana Mehran, Joel T Dudley, Jagat Narula, Samin K Sharma, Annapoorna S Kini
Residual atherothrombotic risk remains higher in patients with versus without diabetes mellitus (DM) despite statin therapy. The underlying mechanisms are unclear. This is a retrospective post-hoc analysis of the YELLOW II trial, comparing patients with and without DM (non-DM) who received rosuvastatin 40 mg for 8-12 weeks and underwent intracoronary multimodality imaging of an obstructive nonculprit lesion, before and after therapy. In addition, blood samples were drawn to assess cholesterol efflux capacity (CEC) and changes in gene expression in peripheral blood mononuclear cells (PBMC)...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28745105/honey-flavonoids-inhibit-hoatp2b1-and-hoatp1a2-transporters-and-hoatp-mediated-rosuvastatin-cell-uptake-in-vitro
#10
Lucie Navrátilová, Jana Ramos Mandíková, Petr Pávek, Přemysl Mladěnka, František Trejtnar
1. Some flavonoids contained in the common diet have been shown to interact with important membrane uptake transporters, including organic anion transporting polypeptides (OATPs). OATP2B1 and OATP1A2 expressed in the apical membrane of human enterocytes may significantly contribute to the intestinal absorption of drugs, e.g. statins. This study is aimed at an evaluation of the inhibitory potency of selected honey flavonoids (namely galangin, myricetin, pinocembrin, pinobanksin, chrysin, fisetin) towards hOATP2B1 and hOATP1A2 as well as at examining their effect on the cellular uptake of the known OATP substrate rosuvastatin...
July 26, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28741244/efficacy-and-safety-of-alternate-day-versus-daily-dosing-of-statins-a-systematic-review-and-meta-analysis
#11
REVIEW
Kamal Awad, Dimitri P Mikhailidis, Peter P Toth, Steven R Jones, Patrick Moriarty, Gregory Y H Lip, Paul Muntner, Alberico L Catapano, Michael J Pencina, Robert S Rosenson, Jacek Rysz, Maciej Banach
PURPOSE: We conducted a meta-analysis of randomized controlled trials (RCTs) and quasi-RCTs to synthesize evidence about the efficacy and safety of alternate-day vs daily dosing of statins. METHODS: We searched selected databases through January 2, 2017 to identify relevant RCTs and quasi-RCTs. The primary outcome was change in low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TG), while secondary outcomes included adverse events and adherence...
July 24, 2017: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/28740344/anti-inflammatory-and-anti-apoptotic-effects-of-rosuvastatin-by-regulation-of-oxidative-stress-in-a-dextran-sulfate-sodium-induced-colitis-model
#12
Seung Kak Shin, Jae Hee Cho, Eui Joo Kim, Eun-Kyung Kim, Dong Kyun Park, Kwang An Kwon, Jun-Won Chung, Kyoung Oh Kim, Yoon Jae Kim
AIM: To evaluate the anti-inflammatory and anti-apoptotic effects of rosuvastatin by regulation of oxidative stress in a dextran sulfate sodium (DSS)-induced colitis model. METHODS: An acute colitis mouse model was induced by oral administration of 5% DSS in the drinking water for 7 d. In the treated group, rosuvastatin (0.3 mg/kg per day) was administered orally before and after DSS administration for 21 d. On day 21, mice were sacrificed and the colons were removed for macroscopic examination, histology, and Western blot analysis...
July 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28733430/atherogenic-lipoprotein-determinants-of-cardiovascular-disease-and-residual-risk-among-individuals-with-low-low-density-lipoprotein-cholesterol
#13
Patrick R Lawler, Akintunde O Akinkuolie, Audrey Y Chu, Svati H Shah, William E Kraus, Damian Craig, Latha Padmanabhan, Robert J Glynn, Paul M Ridker, Daniel I Chasman, Samia Mora
BACKGROUND: Levels of LDL (low-density lipoprotein) cholesterol in the population are declining, and increasing attention is being focused on residual lipid-related pathways of atherosclerotic cardiovascular disease risk beyond LDL cholesterol. Among individuals with low (<130 mg/dL) LDL cholesterol, we undertook detailed profiling of circulating atherogenic lipoproteins in relation to incident cardiovascular disease in 2 populations. METHODS AND RESULTS: We performed proton nuclear magnetic resonance spectroscopy to quantify concentrations of LDL and VLDL (very low-density lipoprotein) particle subclasses in 11 984 JUPITER trial participants (NCT00239681)...
July 21, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28729172/ascorbic-acid-supplementation-partially-prevents-the-delayed-reproductive-development-in-juvenile-male-rats-exposed-to-rosuvastatin-since-prepuberty
#14
Gabriel Adan Araújo Leite, Thamiris Moreira Figueiredo, Marciana Sanabria, Ana Flávia Mota Gonçalves Dias, Patrícia Villela E Silva, Airton da Cunha Martins Junior, Fernando Barbosa Junior, Wilma De Grava Kempinas
Dyslipidemias are occurring earlier in the population due to the increase of obesity and bad eating habits. Rosuvastatin inhibits the enzyme HMG-CoA reductase, decreasing total cholesterol. Ascorbic acid is an important antioxidant compound for male reproductive system. This study aimed to evaluate whether ascorbic acid supplementation may prevent the reproductive damage provoked by rosuvastatin administration at prepuberty. Male pups were distributed into six experimental groups that received saline solution 0...
July 18, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28725138/comparative-assessment-of-saliva-and-plasma-for-drug-bioavailability-and-bioequivalence-studies-in-humans
#15
Nasir M Idkaidek
Aims: To study the pharmacokinetics of selected drugs in plasma and saliva matrixes in healthy human volunteers, and to suggest using non-invasive saliva sampling instead of plasma as a surrogate in bioavailability and bioequivalence (BA/BE) studies. Methods: Four different pilot BA/BE studies were done in 12-18 healthy humans. Saliva and plasma samples were collected for 3-5 half life values of metformin, tolterodine, rosuvastatin, and paracetamol after oral dosing. Saliva and plasma samples were assayed using LC-MSMS, and then pharmacokinetic parameters were calculated by non-compartmental analysis using Kinetica program...
July 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28721135/a-comprehensive-guidelines-based-approach-reduces-cardiovascular-risk-in-everyday-practice-the-varo-study
#16
Tomáš Štulc, Věra Lánská, Michaela Šnejdrlová, Michal Vrablík, Martina Prusíková, Richard Češka
INTRODUCTION: The aim of study was to investigate the possibility of cardiovascular risk improvement through systematic identification of high-risk individuals and treatment in accordance with current guidelines using modern therapy in daily clinical practice. MATERIAL AND METHODS: Two hundred and sixty-three physicians participated in the study. The physicians were asked to screen for cardiovascular risk factors in patients presenting with unrelated problems and to re-evaluate the attainment of treatment goals in those with already known risk factors...
June 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28711864/high-intensity-statin-therapy-is-associated-with-improved-survival-in-patients-with-peripheral-artery-disease
#17
T Raymond Foley, Gagan D Singh, Damianos G Kokkinidis, Ho-Hin K Choy, Thai Pham, Ezra A Amsterdam, John C Rutledge, Stephen W Waldo, Ehrin J Armstrong, John R Laird
BACKGROUND: The relative benefit of higher statin dosing in patients with peripheral artery disease has not been reported previously. We compared the effectiveness of low- or moderate-intensity (LMI) versus high-intensity (HI) statin dose on clinical outcomes in patients with peripheral artery disease. METHODS AND RESULTS: We reviewed patients with symptomatic peripheral artery disease who underwent peripheral angiography and/or endovascular intervention from 2006 to 2013 who were not taking other lipid-lowering medications...
July 15, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28706385/acylation-stimulating-protein-is-a-surrogate-biomarker-for-acute-myocardial-infarction-role-of-statins
#18
Hayder M Al-Kuraishy, Ali I Al-Gareeb
BACKGROUND: Acylation-stimulating protein (ASP) is an adipokine synthesized within adipocytes environment due to adipocyte differentiation. AIM: The aim of this study was to assess changes in ASP levels in patients with acute myocardial infarction (MI) and to correlate these variations with disease variables. SUBJECTS AND METHODS: A total number of 111 patients previously and currently treated with rosuvastatin or atorvastatin presented with acute MI in a Coronary Care Unit, were divided into three groups, Group A: Thirty-nine patients treated with atorvastatin, Group B: Thirty patients treated with rosuvastatin, compared to 42 patients presented with MI not previously treated with statins were enrolled in this study...
July 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28697767/the-impact-of-the-time-of-drug-administration-on-the-effectiveness-of-combined-treatment-of-hypercholesterolemia-with-rosuvastatin-and-ezetimibe-roseze-study-protocol-for-a-randomized-controlled-trial
#19
Karolina Obońska, Michał Kasprzak, Joanna Sikora, Ewa Obońska, Krzysztof Racki, Natalia Goździkiewicz, Magdalena Krintus, Jacek Kubica
BACKGROUND: Hypercholesterolemia is one of the main risk factors for cardiovascular disease. The first line treatment for hypercholesterolemia is statin therapy. When the expected low-density lipoprotein cholesterol (LDL-C) concentration is not achieved, the pharmacotherapy may be extended by combining the statin with the cholesterol absorption inhibitor ezetimibe. METHODS/DESIGN: The study is designed as a randomized, open-label, single-center, crossover study evaluating the effectiveness of combined therapy with rosuvastatin and ezetimibe for hypercholesterolemia...
July 11, 2017: Trials
https://www.readbyqxmd.com/read/28685516/comparison-between-atorvastatin-and-rosuvastatin-in-renal-function-decline-among-patients-with-diabetes
#20
Eugene Han, Gyuri Kim, Ji Yeon Lee, Yong Ho Lee, Beom Seok Kim, Byung Wan Lee, Bong Soo Cha, Eun Seok Kang
BACKGROUND: Although the beneficial effects of statin treatment in dyslipidemia and atherosclerosis have been well studied, there is limited information regarding the renal effects of statins in diabetic nephropathy. We aimed to investigate whether, and which, statins affected renal function in Asian patients with diabetes. METHODS: We enrolled 484 patients with diabetes who received statin treatment for more than 12 months. We included patients treated with moderate-intensity dose statin treatment (atorvastatin 10 to 20 mg/day or rosuvastatin 5 to 10 mg/day)...
June 2017: Endocrinology and Metabolism
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