keyword
MENU ▼
Read by QxMD icon Read
search

Rosuvastatin

keyword
https://www.readbyqxmd.com/read/28322941/small-dosing-clinical-study-pharmacokinetic-pharmacogenomic-slco2b1-and-abcg2-and-interaction-atorvastatin-and-grapefruit-juice-profiles-of-five-probes-for-oatp2b1-and-bcrp
#1
Yushi Kashihara, Ichiro Ieiri, Takashi Yoshikado, Maeda Kazuya, Masato Fukae, Miyuki Kimura, Takeshi Hirota, Shunji Matsuki, Shin Irie, Noritomo Izumi, Hiroyuki Kusuhara, Yuichi Sugiyama
The aims of this study were (1) to investigate the effects of atorvastatin (10 mg, therapeutic dose) and grapefruit juice (GFJ), inhibitors of OATP2B1, on the pharmacokinetics of substrates for OATP2B1 and BCRP under oral small-dosing conditions (300 μg sulfasalazine, 250 μg rosuvastatin, 300 μg glibenclamide, 1200 μg celiprolol, and 600 μg sumatriptan), and (2) to evaluate the contribution of SLCO2B1*3 and ABCG2 c.421C>A polymorphisms to the pharmacokinetics of the five test drugs in 23 healthy volunteers...
March 17, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28319871/autoantibodies-and-immune-complexes-to-oxidation-specific-epitopes-and-progression-of-aortic-stenosis-results-from-the-astronomer-trial
#2
Romain Capoulade, Kwan L Chan, Patrick Mathieu, Yohan Bossé, Jean G Dumesnil, James W Tam, Koon K Teo, Xiaohong Yang, Joseph L Witztum, Benoit J Arsenault, Jean-Pierre Després, Philippe Pibarot, Sotirios Tsimikas
BACKGROUND AND AIMS: Elevated levels of lipoprotein(a) [Lp(a)] and oxidized phospholipids on apolipoprotein B-100 (OxPL-apoB) predict the progression of pre-existing mild-to-moderate calcific aortic valve stenosis (CAVS). Whether indirect markers of oxidation-specific epitopes (OSE) are also predictive is not known. The association between IgG and IgM autoantibodies and malondialdehyde-modified low density lipoprotein (MDA-LDL) and IgG and IgM apolipoprotein B immune complexes (apoB-IC), and the hemodynamic progression rate of CAVS was determined in the ASTRONOMER (Aortic Stenosis Progression Observation: Measuring Effects of Rosuvastatin, NCT00800800) trial...
March 9, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28319370/uptake-and-disposition-of-select-pharmaceuticals-by-bluegill-exposed-at-constant-concentrations-in-a-flow-through-aquatic-exposure-system
#3
Jian-Liang Zhao, Edward T Furlong, Heiko L Schoenfuss, Dana Ward Kolpin, Kyle L Bird, David J Feifarek, Eric A Schwab, Guang-Guo Ying
The increasing use of pharmaceuticals has led to their subsequent input into and release from wastewater treatment plants, with corresponding discharge into surface waters that may subsequently exert adverse effects upon aquatic organisms. Although the distribution of pharmaceuticals in surface water has been extensively studied, the details of uptake, internal distribution, and kinetic processing of pharmaceuticals in exposed fish have received less attention. For this research, we investigated the uptake, disposition, and toxicokinetics of five pharmaceuticals (diclofenac, methocarbamol, rosuvastatin, sulfamethoxazole, and temazepam) in bluegill sunfish (Lepomis macrochirus) exposed to environmentally relevant concentrations (1,000-4,000 ng L-1) in a flow-through exposure system...
March 20, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28296193/investigating-transporter-mediated-drug-drug-interactions-using-a-physiologically-based-pharmacokinetic-model-of-rosuvastatin
#4
Q Wang, M Zheng, T Leil
Rosuvastatin is a frequently used probe in transporter-mediated drug-drug interaction (DDI) studies. This report describes the development of a physiologically based pharmacokinetic (PBPK) model of rosuvastatin for prediction of pharmacokinetic (PK) DDIs. The rosuvastatin model predicted the observed single (i.v. and oral) and multiple dose PK profiles, as well as the impact of coadministration with transporter inhibitors. The predicted effects of rifampin and cyclosporine (6.58-fold and 5.07-fold increase in rosuvastatin area under the curve (AUC), respectively) were mediated primarily via inhibition of hepatic organic anion-transporting polypeptide (OATP)1B1 (Inhibition constant (Ki ) ∼1...
March 13, 2017: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/28294868/-rosuvastatin-in-coronary-bypass-surgery-whether-only-secondary-prevention
#5
A V Panov, M L Gordeev, L B Mitrofanova, E V Kuleshov, M I Buthashvili, I T Abesadze, M Z Alugishvili, N L Lohovinina, K V Korzhenevskaya
BACKGROUND AND AIM: The increasing number of coronary artery bypass grafting (CABG) is associated with a need for active introduction of methods improving immediate and long-term results of these interventions. Results of a number of studies conducted during recent years allow to consider high dose statin therapy one of such methods. In this article we present results of rosuvastatin administration to patients with ischemic heart disease (IHD) prior to surgery. METHODS: Rosuvastatin (40 mg/day) was given for 4 weeks before CABG to patients who had previously taken simvastatin (20 mg/day)...
May 2016: Kardiologiia
https://www.readbyqxmd.com/read/28291622/a-randomized-controlled-comparison-of-different-intensive-lipid-lowering-therapies-in-chinese-patients-with-non-st-elevation-acute-coronary-syndrome-nste-acs-ezetimibe-and-rosuvastatin-versus-high-dose-rosuvastatin
#6
Dan Ran, Hui-Juan Nie, Yu-Lin Gao, Song-Bai Deng, Jian-Lin Du, Ya-Jie Liu, Xiao-Dong Jing, Qiang She
BACKGROUND: Statin combined with ezetimibe demonstrates significant benefit in lowering low density lipid cholesterol (LDL-C) and cardiovascular events abroad, but whether intermediate intensity statins combined with ezetimibe is superior to high-intensity statin monotherapy in Chinese people is unknown. METHODS: A total of 125 patients were randomly assigned to a intermediate intensity rosuvastatin group (rosuvastatin 10mg/d, n=42), high-dose rosuvastatin group (rosuvastatin 20mg/d, n=41) or combination therapy group (ezetimibe 10mg/d and rosuvastatin 10mg/d, n=42) with a 12-week follow-up...
February 23, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28290847/-comparative-analysis-of-the-efficacy-and-safety-of-rosuvastatin-and-original-rosuvastatin
#7
B Ya Bart, E E Luchinkina, I G Gordeev, G P Arutyunov, E O Taratukhin On Behalf Of The Workgroup Of Paritet Trial
The study is one of the priority points of the Russian Scientific Medical Society of Internal Medicine, initiated due to known high average level of LDL cholesterol in Russian population and necessity for its optimized control by better access to treatment. AIM: To conduct comparative analysis of efficacy and safety of the rosuvastatin compound akorta and original rosuvastatin crestor. MATERIAL AND METHODS: To randomized crossover study (PARITET) 60 patients were included with the diagnosis dyslipidemia...
June 2016: Kardiologiia
https://www.readbyqxmd.com/read/28287014/preparation-and-optimization-of-tablets-containing-a-self-nano-emulsifying-drug-delivery-system-loaded-with-rosuvastatin
#8
Heba F Salem, Rasha M Kharshoum, Abdel Khalek A Halawa, Demiana M Naguib
BACKGROUND: Rosuvastatin (ROS) calcium is the latest synthetic drug in the statin group that has an anti-hyperlipidemic activity. It is available as tablets, and its poor aqueous solubility, slow dissolution rate and low-absorption extent result in less than 20% bioavailability and about 80% being excreted unchanged in the feces without absorption. OBJECTIVE: To utilize nanotechnology to reformulate ROS as a self-nano-emulsifying drug delivery system (SNEDDS), and utilizing design optimization to fabricate the SNEDDS as a tablet...
March 13, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28277855/using-lower-cost-statins-improves-outcomes-for-normal-cholesterol-non-diabetic-patients
#9
Ronen Arbel, Dan Greenberg
BACKGROUND The American College of Cardiology recommends considering initiation of cholesterol-lowering therapy in normal cholesterol adults aged 45-70, who are either diabetic or have a 10 year atherosclerotic cardiovascular disease higher than 7.5%. Although this policy was shown to be cost-effective, the multi-billion dollar budget impact may limit the adoption, diffusion and overall clinical impact of this therapy. OBJECTIVES We examined whether using a substantially lower cost statin (Simvastatin) in a much wider population, while accepting almost-as-good per-patient outcomes can provide better outcomes for the entire intended use population (IUP) under a pre-specified budget constraint...
February 21, 2017: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/28276528/variability-in-statin-induced-changes-in-gene-expression-profiles-of-pancreatic-cancer
#10
Helena Gbelcová, Silvie Rimpelová, Tomáš Ruml, Marie Fenclová, Vítek Kosek, Jana Hajšlová, Hynek Strnad, Michal Kolář, Libor Vítek
Statins, besides being powerful cholesterol-lowering drugs, also exert potent anti-proliferative activities. However, their anti-cancer efficacy differs among the individual statins. Thus, the aim of this study was to identify the biological pathways affected by individual statins in an in vitro model of human pancreatic cancer. The study was performed on a human pancreatic cancer cell line MiaPaCa-2, exposed to all commercially available statins (12 μM, 24 h exposure). DNA microarray analysis was used to determine changes in the gene expression of treated cells...
March 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28263871/effects-of-statins-on-the-immunoglobulin-g-glycome
#11
Toma Keser, Frano Vučković, Clara Barrios, Jonas Zierer, Annika Wahl, Akintunde O Akinkuolie, Jerko Štambuk, Natali Nakić, Tamara Pavić, Josipa Periša, Samia Mora, Christian Gieger, Cristina Menni, Tim D Spector, Olga Gornik, Gordan Lauc
BACKGROUND: Statins are among the most widely prescribed medications worldwide and usually many individuals involved in clinical and population studies are on statin therapy. Immunoglobulin G (IgG) glycosylation has been associated with numerous cardiometabolic risk factors. METHODS: The aim of this study was to investigate the possible association of statin use with N-glycosylation of IgG. The association was analyzed in two large population cohorts (TwinsUK and KORA) using hydrophilic interaction liquid chromatography (HILIC-UPLC) in the TwinsUK cohort and reverse phase liquid chromatography coupled with electrospray mass spectrometry (LC-ESI-MS) in the KORA cohort...
March 2, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28263812/prognostic-effects-of-rosuvastatin-in-patients-with-co-existing-chronic-obstructive-pulmonary-disease-and-chronic-heart-failure-a-sub-analysis-of-gissi-hf-trial
#12
Andrea Rossi, Riccardo M Inciardi, Andrea Rossi, Pier Luigi Temporelli, Donata Lucci, Lucio Gonzini, Roberto Marchioli, Gian Luigi Nicolosi, Luigi Tavazzi
OBJECTIVES: Rising evidences showed a possible protective role of statins in chronic obstructive pulmonary disease (COPD). We aimed to evaluate in a post-hoc analysis of the GISSI-HF trial the prognostic effect of the use of rosuvastatin in patients with co-existing COPD and HF, assuming that the anti-inflammatory properties of these drugs may imply a potential beneficial effect in these associated chronic inflammatory conditions. METHODS: We analyzed patients with chronic HF and history of COPD deriving from the GISSI-HF study...
March 2, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28260863/pharmacokinetic-interactions-between-glimepiride-and-rosuvastatin-in-healthy-korean-subjects-does-the-slco1b1-or-cyp2c9-genetic-polymorphism-affect-these-drug-interactions
#13
Choon Ok Kim, Eun Sil Oh, Hohyun Kim, Min Soo Park
To improve cardiovascular outcomes, dyslipidemia in patients with diabetes needs to be treated. Thus, these patients are likely to take glimepiride and rosuvastatin concomitantly. Therefore, this study aimed to evaluate the pharmacokinetic (PK) interactions between these two drugs in healthy males and to explore the effect of SLCO1B1 and CYP2C9 polymorphisms on their interactions in two randomized, open-label crossover studies. Glimepiride was studied in part 1 and rosuvastatin in part 2. Twenty-four participants were randomly assigned to each part...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28258068/novel-method-to-predict-in-vivo-liver-to-plasma-kpuu-for-oatp-substrates-using-suspension-hepatocytes
#14
Keith Riccardi, Jian Lin, Zhenhong Li, Mark Niosi, Sangwoo Ryu, Wenyi Hua, Karen Atkinson, Rachel E Kosa, John Litchfield, Li Di
The ability to predict human liver-to-plasma unbound partition coefficient (Kpuu) is of great importance to estimate unbound liver concentration, develop PK/PD relationships, predict efficacy and toxicity in the liver, and model drug-drug interaction (DDI) potential for drugs that are asymmetrically distributed into the liver. A novel in vitro method has been developed to predict in vivo Kpuu with good accuracy using cryopreserved suspension hepatocytes in InVitroGRO HI media with 4% BSA. Validation was performed using six OATP substrates with rat in vivo Kpuu data from IV infusion studies where steady state was achieved...
March 3, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28257284/pharmacogenomics-and-tailored-polypharmacy-an-80-year-old-lady-with-rosuvastatin-associated-rhabdomyolysis-and-maprotiline-related-ogilvie-s-syndrome%C3%A2
#15
Katherina B Sreter, Blazenka Barisic, Sanja Popovic-Grle
What is known and objectives: Multiple adverse drug reactions (ADRs) are expected, and thus should be prevented in the elderly comorbid patient on polypharmacy. Rosuvastatin is commonly prescribed for the treatment and prevention of atherosclerotic diseases, and in rare cases, is associated with rhabdomyolysis. Maprotiline is a tetracyclic antidepressant, infrequently used in the United States, but seemingly more broadly in European countries. Acute colonic pseudo-obstruction (Ogilvie's syndrome) caused by maprotiline has thus far, to our knowledge, not yet been described in the literature...
March 3, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28256038/rosuvastatin-promotes-benefits-on-induced-periodontitis-in-hypertensive-rats
#16
M R Messora, G H Apolinário Vieira, J M T M M Vanderlei, V C Mariguela, P G Fernandes, D B Palioto, S L Scombatti de Souza, A B Novaes, F Furlaneto, M Taba
BACKGROUND AND OBJECTIVE: The potential benefits of statins in modulating periodontal disease is supported by in vitro and clinical studies showing statins can induce a lower expression of proinflammatory cytokines and matrix metalloproteinases. The aim of this study was to evaluate the effects of rosuvastatin (ST) on ligature-induced periodontitis in spontaneously hypertensive rats (SHR). MATERIAL AND METHODS: Fifty-four adult male rats were divided into three groups: SHR-C, SHR-L and SHR-L-ST (C, control; L, ligature groups)...
March 2, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28251662/analysis-and-comparison-of-the-cost-effectiveness-of-statins-according-to-the-baseline-low-density-lipoprotein-cholesterol-level-in-korea
#17
Y J Jeong, H Kim, S J Baik, T M Kim, S J Yang, S-H Lee, J-H Cho, H Lee, H W Yim, I Y Choi, K-H Yoon, H-S Kim
WHAT IS KNOWN AND OBJECTIVE: There are a few Korean studies on the economics of statins based on reduction in low-density lipoprotein cholesterol (LDL-C) data from other countries. This study aimed to analyse and compare the cost-effectiveness of statins according to the baseline LDL-C level in Korea. METHODS: Between January 2009 and December 2015, the data of patients who were prescribed statins for the first time were extracted from electronic medical records...
March 1, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28249380/statins-in-primary-prevention-impact-on-mortality-a-meta-analysis-study
#18
José P Lopes Nunes
AIM: An evaluation of the effects of statins on total mortality in the context of primary prevention was carried out, by means of the analysis of data taken from major clinical trials published in the literature. METHODS: Published systematic reviews were used to identify relevant clinical trials, and data from the third Heart Outcomes Prevention Evaluation study were also used. Meta-analysis was carried out using overall mortality data. RESULTS: A total of nine clinical trials were selected for further study, and in each of them patients had defined cardiovascular risk factors...
March 1, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28247468/discovery-and-quantitative-structure-activity-relationship-study-of-lepidopteran-hmg-coa-reductase-inhibitors-as-selective-insecticides
#19
Yang-Yang Zang, Yuan-Mei Li, Yue Yin, Shan-Shan Chen, Zhen-Peng Kai
BACKGROUND: In the previous study, we have demonstrated that insect 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) can be a potential selective insecticide target. Three series of inhibitors were designed based on the difference of HMGR structures from Homo sapiens and Manduca sexta with the aim for discovering potent selective insecticide candidate. RESULTS: Bioassay in vitro showed that gem-difluoromethylenated statin analogs have potent effects on JH biosynthesis of M...
March 1, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28243357/comparison-of-effects-of-different-statins-on-contrast-induced-acute-kidney-injury-in-rats-histopathological-and-biochemical-findings
#20
COMPARATIVE STUDY
Xiao-Lei Wang, Tuo Zhang, Liu-Hua Hu, Shi-Qun Sun, Wei-Feng Zhang, Zhe Sun, Ling-Hong Shen, Ben He
Statins are a promising new strategy to prevent contrast-induced acute kidney injury (CI-AKI). In this study we compared the ameliorative effect of different statins in a rat model of CI-AKI. Sprague-Dawley rats were divided into five groups: control group; CI-AKI group; CI-AKI + rosuvastatin group (10 mg/kg/day); CI-AKI + simvastatin group (80 mg/kg/day); and CI-AKI + atorvastatin group (20 mg/kg/day). CI-AKI was induced by dehydration for 72 hours, followed by furosemide intramuscular injection 20 minutes before low-osmolar contrast media (CM) intravenous injection...
2017: Oxidative Medicine and Cellular Longevity
keyword
keyword
6832
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"