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Young MSM

Kristi E Gamarel, Larry Brown, Christopher W Kahler, M Isabel Fernandez, Douglas Bruce, Sharon Nichols
OBJECTIVES: The purpose of this study was to better understand the prevalence and correlates of substance use behaviors among HIV-infected adolescents in HIV care settings. METHODS: A cross-sectional sample of 2216 youth living with HIV (YLWH; ages 12-26) were recruited through the Adolescent Trials Network for HIV Interventions. Participants completed a one-time survey on sociodemographic factors, substance use and health behaviors. We used logistic regression models to understand the correlates of substance use outcomes...
October 11, 2016: Drug and Alcohol Dependence
Bin Li, Peng Bi, Eric P F Chow, Basil Donovan, Anna McNulty, Alison Ward, Charlotte Bell, Christopher K Fairley
Background: After reviewing urethral gonorrhoea cases among men who have sex with men (MSM) at the South Australia Specialist Sexual Health (SASSH) in Adelaide, Australia, we noticed peaks of gonorrhoea among MSM occurred predominantly in the first quarter of the year (January-March). The aim of this study was to formally test this hypothesis against data from a similar period at three sexual health services, one each in Adelaide, Melbourne and Sydney. Methods: This study was a retrospective analysis of computerised records at the three Australian sexual health services...
October 7, 2016: Sexual Health
H J He, P Lyu, R S Luan, Q H Liao, Z J Chang, Y Li, L Ouyang, J Yang
Objective: To understand how social and cultural factors influence sexual perceptions, sexual practices, and HIV transmission among men who have sex with men at selected sites in China. Methods: Qualitative methodology was used and face to face, semi-structured, in-depth interviews conducted from April 2013 to October 2015 in Sichuan, Jiangxi, Henan, Heilongjiang provinces and Chongqing municipality of China. Results: A total of 184 men who have sex with men participated in the interviews. Forty-eight originated from Henan Province, and 12, 50, 47, and 27 from Jiangxi, Heilongjiang, Sichuan provinces and Chongqing municipality, respectively...
October 6, 2016: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
Richard A Crosby, Leandro Mena
This study of young Black MSM (YBMSM) explored the correlates and outcomes of enhanced sexual pleasure from condom-protected sex. Six-hundred YBMSM were enrolled from an sexually transmitted infection clinic in the southern United States. Men completed a computer-assisted self-interview. A 3-item scale assessed perceptions related to condoms enhancing sexual pleasure. Nine of 14 correlates met the screening level of significance and were tested in a regression model. Three obtained multivariable significance: (1) Men discussing condom use with sex partners had greater odds (AOR = 1...
September 28, 2016: AIDS and Behavior
Kristin Keglovitz, Andrew D Richardson, Nicola Lancki, Tim Walsh, John A Schneider
PURPOSE: Limited data are available on anal squamous intraepithelial lesions (ASILs) and anal human papillomavirus (HPV) infection in young, black populations. The purpose of this study was to examine the prevalence of and relationships between ASILs and high-risk HPV infection in a young (<30 years of age), predominately black, men who have sex with men (MSM) population. METHODS: Results of anal cytology and HPV DNA were gathered for 83 individuals. RESULTS: Forty-two percent of individuals (35) had atypical squamous cells of undetermined significance and 33% (27) had low-grade intraepithelial lesion by cytology...
September 27, 2016: LGBT Health
Cynthia L Gay, Sarah J Willis, Anna B Cope, JoAnn D Kuruc, Kara S Mcgee, Joe Sebastian, Amanda M Crooks, Mehri S Mckellar, David M Margolis, Susan A Fiscus, Charles B Hicks, Guido Ferrari, Joseph J Eron
BACKGROUND: Updated guidelines recommend immediate antiretroviral treatment (ART) during acute HIV infection (AHI), but efficacy data on regimens during AHI are limited. METHODS: We provide final data on a prospective, single-arm 96-week open label study of once daily emtricitabine/tenofovir/efavirenz initiated during AHI. The primary endpoint was the proportion of responders with HIV RNA <200 copies/mL by week 24. We examined time-to-viral-suppression, retention and CD8 cell activation through week 96 in relation to baseline characteristics...
September 20, 2016: AIDS
Sybil Hosek, Bret Rudy, Raphael Landovitz, Bill Kapogiannis, George Siberry, Brandy Rutledge, Nancy Liu, Jennifer Brothers, Kathleen Mulligan, Gregory Zimet, Michelle Lally, Ken Mayer, Peter Anderson, Jennifer Kiser, Jim Rooney, Craig M Wilson
BACKGROUND: Young men who have sex with men (YMSM) are a key population for implementation of PrEP interventions. This open-label study examined adherence to PrEP and assessed sexual behavior among a diverse sample of YMSM in 12 U.S. cities. METHODS: Eligible participants were 18-22 year old HIV-uninfected MSM who reported HIV transmission risk behavior in the past 6 months. Participants were provided daily TDF/FTC (Truvada®). Study visits occurred at baseline, monthly through week 12, then quarterly through week 48...
September 13, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Inês Sousa-Lima, Shin-Young Park, Michelle Chung, Hyun Ju Jung, Min-Cheol Kang, Joana M Gaspar, Ji A Seo, M Paula Macedo, Kyong Soo Park, Christos Mantzoros, Seung-Hoon Lee, Young-Bum Kim
Methylsulfonylmethane (MSM), an organosulfur compound, has been used as a dietary supplement that can improve various metabolic diseases. However, the effect of MSM on obesity-linked metabolic disorders remains unclear. The goal of the current study is to determine whether MSM has beneficial effects on glucose and lipid homeostasis in obesity-associated pathophysiologic states. High-fat diet-induced obese (DIO) and genetically obese diabetic db/db mice treated with MSM (1%-5% v/v, by drinking water) were studied...
October 2016: Metabolism: Clinical and Experimental
Michael C Clatts, Lloyd A Goldsamt, Lê Minh Giang, Lê Quốc Bảo, Gary Yu, Donn Colby
Background: Urban centres in Vietnam have high rates of HIV infection, especially among men who have sex with men (MSM). A subgroup of MSM, young male sex workers (YMSW), are at especially high risk due to concurrent sex with multiple male and female partners, low levels of knowledge regarding HIV and sexually transmissible infection (STI) transmission, and limited engagement with health services, including STI and HIV screening and treatment. Methods: A targeted intervention (SHEATH) derived from Harm Reduction and Sexual Health Promotion intervention technology was implemented in an out-of-treatment population of YMSW in Hanoi and Ho Chi Minh City (n=919)...
September 9, 2016: Sexual Health
Roberto Rossotti, Vanni Borghi, Anna Paola Callegaro, Valeria Micheli, Bianca Bruzzone, Grazia Colao, Maria Rita Gismondo, Ilaria Vicenti, Giovanni Penco, Maurizio Zazzi, Stefano Rusconi
BACKGROUND: PrEP with FTC/TDF has shown great efficacy in preventing new HIV infections but issues remain (low adherence, high costs, toxicity and resistance development). No data are available about the impact of circulating Resistance-Associated Mutations (RAMs) on its efficacy. OBJECTIVES: describe the prevalence of FTC and/or TDF-related RAMs in Italian HIV-infected population and their potential impact on PrEP efficacy. STUDY DESIGN: ARCA is a national database that collects data about RAMs and epidemiological correlates from sites throughout Italy; it was queried about the prevalence of these RAMs in the last decade...
October 2016: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Brian A Feinstein, Brent A Johnson, Jeffrey T Parsons, Brian Mustanski
Receiving an HIV-positive test result is associated with reduced condomless anal sex (CAS), but little is known about negative test results. The recent development of the Inventory of Reactions to Testing HIV Negative confirmed that there are diverse reactions to receiving a negative test result, which have implications for risk behaviour. The goals of the current study were to validate the measure in a sample of young men who have sex with men who recently tested HIV-negative (N = 1113) and to examine its associations with CAS...
August 24, 2016: AIDS and Behavior
Vorapot Sapsirisavat, Nittaya Phanuphak, Siriwan Keadpudsa, James E Egan, Kanitta Pussadee, Preeyarach Klaytong, M Reuel Friedman, Frits van Griensven, Ron Stall
HIV prevalence remains high in men who have sex with men (MSM) in Bangkok. Even though resources for HIV testing and treatment are available for all, a large proportion of MSM still do not get HIV tested. We studied high risk MSM who are unaware of their HIV status to help maximize effectiveness of our resources. Convenience sampling was conducted among MSM who came for HIV testing at the Thai Red Cross Anonymous Clinic and two popular drop-in centers in Bangkok. Inclusion criteria were MSM aged >18 years, have not been tested positive for HIV, who reported ≥1 of the following in the previous 6 months: condomless sex with a male, being a sex worker, or having a sexual transmitted infection diagnosis...
August 23, 2016: AIDS and Behavior
Ian Holloway, Ryan Dougherty, Jennifer Gildner, Sean C Beougher, Craig Pulsipher, Jorge A Montoya, Aaron Plant, Arleen Leibowitz
We investigated PrEP uptake, adherence, and discontinuation among young app-using MSM in California (N=761). 9.7% of participants had ever used PrEP; 87% of those deemed good candidates for screening (indicated by a CDC risk index score ≥10) were not current or past users. PrEP use was associated with higher income (aOR:4.13; CI:1.87-9.12), receptive condomless anal sex (aOR:3.41; CI:1.71-6.78), HIV-positive sex partners (aOR:2.87; CI:1.53-5.38), popper use (aOR:3.47; CI:1.96-6.13), and recent STI diagnosis (aOR:2...
August 19, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Brenda Hoagland, Raquel B De Boni, Ronaldo I Moreira, José Valdez Madruga, Esper G Kallas, Silvia Pereira Goulart, Natalia Cerqueira, Thiago S Torres, Paula M Luz, Nilo Martinez Fernandes, Albert Y Liu, Beatriz Grinsztejn, Valdilea G Veloso
Antiretroviral pre-exposure prophylaxis (PrEP) is recommended to prevent HIV infection among high-risk men who have sex with men (MSM) though not available in Brazil where the HIV epidemic persists unabated in this group. This cross-sectional study describes PrEP awareness and willingness and associated factors among MSM and transvestite/transgender women (trans women) pre-screened for the PrEP Brasil study. Awareness was reported by 61.3 % of the participants and was associated with age, education, site, study period and prior HIV testing...
August 17, 2016: AIDS and Behavior
Cecilia Tomori, Allison M McFall, Aylur K Srikrishnan, Shruti H Mehta, Nymisha Nimmagadda, Santhanam Anand, Canjeevaram K Vasudevan, Suniti Solomon, Sunil S Solomon, David D Celentano
BACKGROUND: Childhood sexual abuse (CSA) is a significant global public health problem, which is associated with negative psychosocial outcomes and high-risk sexual behaviors in adults. Men who have sex with men (MSM) often report higher prevalence of CSA history than the general population, and CSA may play a key role in MSM's greater vulnerability to HIV. METHODS: This study examined the prevalence of CSA history and its impact on the number of recent HIV-related risk behaviors (unprotected anal intercourse, high number of male and female sexual partners, alcohol use, drug use, and sex work in prior 6 months) and lifetime risk behaviors and experiences (high number of lifetime male and female sexual partners, early sexual debut, injection drug use, sex work, and intimate partner violence) among 11,788 adult MSM recruited via respondent driven sampling across 12 sites in India, with additional insights from thematic analysis of qualitative research with 363 MSM from 15 sites...
2016: BMC Public Health
P Flowers, J Riddell, C Park, B Ahmed, I Young, J Frankis, M Davis, M Gilbert, C Estcourt, L Wallace, L M McDaid
OBJECTIVES: The aim of the study was to explore preparedness for the HIV self-test among men who have sex with men (MSM) and those involved in HIV prevention and care. METHODS: A mixed methods exploratory research design was employed, detailing awareness and willingness to use the self-test and the perceived barriers and facilitators to implementation. Quantitative and qualitative data collection and analysis were completed in parallel. Descriptive and inferential analysis of cross-sectional bar-based survey data collected from MSM through a self-completed questionnaire and oral fluid specimen collection (n = 999) was combined with qualitative, thematic, analysis of data collected through 12 expert focus groups (n = 55) consisting of gay men, National Health Service (NHS) staff, community organizations, entrepreneurs and activists...
August 5, 2016: HIV Medicine
Shauna Stahlman, Carrie Lyons, Patrick S Sullivan, Kenneth H Mayer, Sean Hosein, Chris Beyrer, Stefan D Baral
The goal to effectively prevent new HIV infections among gay, bisexual, and other men who have sex with men (MSM) is more challenging now than ever before. Despite declines in the late 1990s and early 2000s, HIV incidence among MSM is now increasing in many low- and high-income settings including the US, with young, adolescent, and racial/ethnic minority MSM being among those at highest risk. Potentiating HIV risks across all settings are individual-, network-, and structural-level factors such as stigma and lack of access to pre-exposure prophylaxis (PrEP) and antiretroviral treatment as prevention...
August 5, 2016: Sexual Health
Mélanie Prague, Daniel Commenges, Jon Michael Gran, Bruno Ledergerber, Jim Young, Hansjakob Furrer, Rodolphe Thiébaut
Highly active antiretroviral therapy (HAART) has proved efficient in increasing CD4 counts in many randomized clinical trials. Because randomized trials have some limitations (e.g., short duration, highly selected subjects), it is interesting to assess the effect of treatments using observational studies. This is challenging because treatment is started preferentially in subjects with severe conditions. This general problem had been treated using Marginal Structural Models (MSM) relying on the counterfactual formulation...
July 26, 2016: Biometrics
Winston E Abara, Kristen L Hess, Robyn Neblett Fanfair, Kyle T Bernstein, Gabriela Paz-Bailey
Globally, men who have sex with men (MSM) are disproportionately burdened with syphilis. This review describes the published literature on trends in syphilis infections among MSM in the US and Western Europe from 1998, the period with the fewest syphilis infections in both geographical areas, onwards. We also describe disparities in syphilis trends among various sub-populations of MSM. We searched electronic databases (Medline, Embase, Global Health, PsychInfo, CAB Abstracts, CINAHL, Sociological Abstracts, Web of Science, Cochrane Library, and LILACS) for peer-reviewed journal articles that were published between January 2004 and June 2015 and reported on syphilis cases among MSM at multiple time points from 1998 onwards...
2016: PloS One
Youn Hee Joung, Pramod Darvin, Dong Young Kang, Nipin Sp, Hyo Joo Byun, Chi-Ho Lee, Hak Kyo Lee, Young Mok Yang
Osteoclast differentiation is dependent on the activities of receptor activator NF-kB ligand (RANKL) and macrophage colony-stimulating factor (M-CSF). Given that RANKL plays a critical role in osteoclast formation and bone resorption, any new compounds found to alter its activity would be predicted to have therapeutic potential for disorders associated with bone loss. Methylsulfonylmethane (MSM) is a naturally occurring sulfur compound with well-documented anti-oxidant and anti-inflammatory properties; currently its effects on osteoclast differentiation are unknown...
2016: PloS One
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