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https://www.readbyqxmd.com/read/28937844/immunogenicity-and-safety-of-the-southern-hemisphere-2015-formulation-of-vaxigrip%C3%A2
#1
Mathilde Latreille-Barbier, Regine Rouzier, Beatrice Astruc, Nathalie Lavis, Yves Donazzolo
An inactivated split-virion trivalent influenza vaccine (IIV3; Vaxigrip®, Sanofi Pasteur) has been available globally since 1968. Here, we describe the results of an open-label, post-licensure trial (EudraCT no. 2014-005078-12) to confirm the immunogenicity and safety of the Southern Hemisphere 2015 formulation of IIV3. Adults 18-60 years of age and > 60 years of age (60 per age group) received a single 0.5-ml intramuscular injection of IIV3. Between baseline and day 21 after vaccination, hemagglutination inhibition (HAI) titers for each strain in IIV3 increased, on average, by at least 11-fold for younger adults and at least 5-fold for older adults...
September 22, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28934061/current-safety-issues-with-quadrivalent-meningococcal-conjugate-vaccines
#2
Tanya R Myers, Michael M McNeil
Invasive meningococcal disease, although rare, can present as sudden, life-threatening disease with high risk of mortality or severe long-term sequelae. The main prevention strategy for invasive meningococcal disease in the United States is the routine vaccination of adolescents and other persons at increased risk of meningococcal disease with quadrivalent meningococcal conjugate vaccines. Two such vaccines are currently licensed and available in the United States, Menactra® (Sanofi Pasteur) and Menveo® (Glaxo Smith Kline), and usage in the adolescent population have steadily increased since their introduction...
September 21, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28933626/immunogenicity-and-safety-of-the-2015-southern-hemisphere-formulation-of-a-split-virion-inactivated-quadrivalent-vaccine
#3
Cecilia Montalban, May Book Montellano, Jaime Santos, Nathalie Lavis
An inactivated split-virion quadrivalent influenza vaccine (IIV4; Fluzone® Quadrivalent; Sanofi Pasteur) has been available in the US since 2013 and in the Southern Hemisphere since 2015. Here, we describe the results of an open-label, post-licensure trial (WHO Universal Trial Number, U1111-1143-9256) to confirm the immunogenicity and safety of the Southern Hemisphere 2015 formulation of IIV4. Adults 18-60 years of age and > 60 years of age (n = 60 per age group) received a single 0.5-mL intramuscular injection of IIV4...
September 21, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28933625/immunogenicity-and-safety-of-a-split-virion-quadrivalent-influenza-vaccine-in-adults-18-60%C3%A2-years-of-age-in-the-republic-of-korea
#4
Won Suk Choi, Ji Yun Noh, Jacob Lee, Jun Yong Choi, Jin-Soo Lee, Moo Soo Kim, Hee Soo Kim, Joon Bang, Nathalie Lavis, Woo Joo Kim
VaxigripTetra® (Sanofi Pasteur, Lyon, France) is a quadrivalent split-virion inactivated influenza vaccine (IIV4) containing two B-lineage strains approved in the European Union and Taiwan in 2016 for individuals ≥ 3 years of age. Here, we describe an observer-blind, randomized, controlled, multicenter trial study evaluating the immunogenicity and safety of the Northern Hemisphere 2015-2016 formulations of IIV4 and the licensed split-virion trivalent inactivated influenza vaccine (IIV3) in the Republic of Korea (ClinicalTrials...
September 21, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28933365/milk-s-role-as-an-epigenetic-regulator-in-health-and-disease
#5
REVIEW
Bodo C Melnik, Gerd Schmitz
It is the intention of this review to characterize milk's role as an epigenetic regulator in health and disease. Based on translational research, we identify milk as a major epigenetic modulator of gene expression of the milk recipient. Milk is presented as an epigenetic "doping system" of mammalian development. Milk exosome-derived micro-ribonucleic acids (miRNAs) that target DNA methyltransferases are implicated to play the key role in the upregulation of developmental genes such as FTO, INS, and IGF1. In contrast to miRNA-deficient infant formula, breastfeeding via physiological miRNA transfer provides the appropriate signals for adequate epigenetic programming of the newborn infant...
March 15, 2017: Diseases (Basel)
https://www.readbyqxmd.com/read/28929807/splenic-artery-embolization-in-blunt-trauma-a-single-center-retrospective-comparison-of-the-use-of-gelatin-sponge-versus-coils
#6
Pasteur Rasuli, Bardia Moosavi, Gordon J French, William Petrcich, Ian Hammond
OBJECTIVE: The purpose of this study was to compare the efficacy of gelatin sponge with that of coils for splenic artery embolization in the treatment of blunt splenic injury. MATERIALS AND METHODS: A single-center retrospective review was performed with the records of 63 patients (45 men, 18 women; mean age, 45.5 years; range, 16-84 years) with blunt splenic injury treated at a tertiary care trauma center by splenic artery embolization with gelatin sponge (n = 30 patients) or metallic coils (n = 33 patients) between 2005 and 2014...
September 20, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28926300/an-updated-scheme-for-categorizing-foods-implicated-in-foodborne-disease-outbreaks-a-tri-agency-collaboration
#7
LaTonia C Richardson, Michael C Bazaco, Cary Chen Parker, Daniel Dewey-Mattia, Neal Golden, Karen Jones, Karl Klontz, Curtis Travis, Joanna Zablotsky Kufel, Dana Cole
BACKGROUND: Foodborne disease data collected during outbreak investigations are used to estimate the percentage of foodborne illnesses attributable to specific food categories. Current food categories do not reflect whether or how the food has been processed and exclude many multiple-ingredient foods. MATERIALS AND METHODS: Representatives from three federal agencies worked collaboratively in the Interagency Food Safety Analytics Collaboration (IFSAC) to develop a hierarchical scheme for categorizing foods implicated in outbreaks, which accounts for the type of processing and provides more specific food categories for regulatory purposes...
September 19, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28918151/internal-transcribed-spacer-its-sequencing-reveals-considerable-fungal-diversity-in-dairy-products
#8
A J Buehler, R L Evanowski, N H Martin, K J Boor, M Wiedmann
Fungi are important spoilage organisms in dairy products. However, little is known about the diversity of naturally occurring spoilage fungi in raw milk and processed dairy products, due at least in part to the fact that classical fungal identification methods require considerable expertise. To gain further insight into the fungal diversity in the dairy system, we isolated fungi from raw milk, raw and pasteurized milk cheese, and yogurt using the selective dichloran rose bengal chloramphenicol agar. In total, 361 fungal isolates were obtained and further characterized by DNA sequencing of the internal transcribed spacer (ITS) region and the nuclear ribosomal large subunit (LSU) rRNA gene if needed...
September 13, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28911629/a-survey-of-aflatoxin-m1-in-cow-milk-in-southern-iran
#9
Majid Hashemi
The competitive enzyme-linked immunosorbent assay technique was used to evaluate aflatoxin M1 (AFM1) levels in 168 samples of raw milk (135 samples and 33 samples from bulk tanks of farms and milk collection centers, respectively) and 12 samples of pasteurized milk in Fars province, Southern Iran. AFM1 was found in 55.56% of the samples with a mean concentration of 21.31 ng/L. The concentration of AFM1 in raw milk samples from farms was significantly (p<0.05) lower than that in samples from collection centers and pasteurized milk...
October 2016: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28890616/clinical-and-practical-implications-of-storage-media-used-for-tooth-avulsion
#10
REVIEW
Vineet Is Khinda, Gurpreet Kaur, Gurlal S Brar, Shiminder Kallar, Heena Khurana
Replantation is being widely accepted as an effective treatment option for an avulsed tooth. However, the long-term fate of replanted teeth is unpredictable; it is dependent on various factors, such as the time interval between avulsion and replantation, extra-alveolar storage period (dry storage or storage media), the vitality status of pulp or periodontal tissues and the type and period of splinting. The appropriate use of storage media is an important clinical factor affecting the postoperative prognosis of avulsed teeth following replantation...
April 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28888104/effects-of-ultraviolet-light-emitting-diodes-leds-on-microbial-and-enzyme-inactivation-of-apple-juice
#11
Merve Pelvan Akgün, Sevcan Ünlütürk
In this study, the effects of Ultraviolet light-emitting diodes (UV-LEDs) on the inactivation of E. coli K12 (ATCC 25253), an indicator organism of E. coli O157:H7, and polyphneoloxidase (PPO) in cloudy apple juice (CAJ) were investigated. The clear (AJ) and cloudy apple juice were exposed to UV rays for 40min by using a UV device composed of four UV-LEDs with peak emissions at 254 and 280nm and coupled emissions as follows: 254/365, 254/405, 280/365, 280/405 and 254/280/365/405nm. UV-LEDs at 254nm achieved 1...
August 15, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28885683/microwave-heating-modelling-of-a-green-smoothie-effects-on-glucoraphanin-sulforaphane-and-s-methyl-cysteine-sulphoxide-changes-during-storage
#12
Noelia Castillejo, Ginés Benito Martínez Hernández, Antonio José Lozano Guerrero, Juan Luis Pedreño Molina, Perla A Gómez, Encarna Aguayo, Francisco Artés, Francisco Artés Hernández
BACKGROUND: The heating of a green smoothie during an innovative semi-continuous microwave treatment (MW; 9 kW for 15 s) was modelled. Thermal and dielectric properties of the samples were previously determined. Furthermore, the heating effect on the main chemopreventive compounds of the smoothie and during its subsequent storage up to 30 days at 5 or 15 °C were studied. Such results were compared to conventional pasteurization (CP; 90 °C for 45 s) while unheated fresh blended samples were used as control (CTRL)...
September 8, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28884331/paratuberculosis-in-latin-america-a-systematic-review
#13
REVIEW
I F Espeschit, D G G Schwarz, A C S Faria, M C C Souza, F A Paolicchi, R A Juste, I A Carvalho, M A S Moreira
Latin America is the definition of the American group, where languages of Latin origin are spoken, including countries in South, Central, and North America. Paratuberculosis is a gastrointestinal contagious chronic disease that affects ruminants, whose etiological agent is the bacilli Mycobacterium avium subsp. paratuberculosis (MAP). Paratuberculosis is characterized by intermittent diarrhea, decreased milk production, dehydration, and progressive weight loss and is possibly involved in Crohn's disease, a human intestinal disease...
September 7, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28882438/biodistribution-and-safety-of-a-live-attenuated-tetravalent-dengue-vaccine-in-the-cynomolgus-monkey
#14
Guillaume Ravel, Nathalie Mantel, Jeremy Silvano, Alexandra Rogue, Bruno Guy, Nicholas Jackson, Nicolas Burdin
BACKGROUND: The first licensed dengue vaccine is a recombinant, live, attenuated, tetravalent dengue virus vaccine (CYD-TDV; Sanofi Pasteur). This study assessed the biodistribution, shedding, and toxicity of CYD-TDV in a non-human primate model as part of the nonclinical safety assessment program for the vaccine. METHODS: Cynomolgus monkeys were given one subcutaneous injection of either one human dose (5log10 CCID50/serotype) of CYD-TDV or saline control. Study endpoints included clinical observations, body temperature, body weight, food consumption, clinical pathology, immunogenicity, and post-mortem examinations including histopathology...
September 4, 2017: Vaccine
https://www.readbyqxmd.com/read/28865849/longitudinal-assessment-of-dairy-farm-management-practices-associated-with-the-presence-of-psychrotolerant-bacillales-spores-in-bulk-tank-milk-on-10-new-york-state-dairy-farms
#15
S N Masiello, D Kent, N H Martin, Y H Schukken, M Wiedmann, K J Boor
The ability of certain spore-forming bacteria in the order Bacillales (e.g., Bacillus spp., Paenibacillus spp.) to survive pasteurization in spore form and grow at refrigeration temperatures results in product spoilage and limits the shelf life of high temperature, short time (HTST)-pasteurized fluid milk. To facilitate development of strategies to minimize contamination of raw milk with psychrotolerant Bacillales spores, we conducted a longitudinal study of 10 New York State dairy farms, which included yearlong monthly assessments of the frequency and levels of bulk tank raw milk psychrotolerant spore contamination, along with administration of questionnaires to identify farm management practices associated with psychrotolerant spore presence over time...
August 30, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28861512/identification-of-a-widespread-palmitoylethanolamide-contamination-in-standard-laboratory-glassware
#16
Roberto Angelini, Donovan A Argueta, Daniele Piomelli, Nicholas V DiPatrizio
Introduction: Fatty acid ethanolamides (FAEs) are a family of lipid mediators that participate in a host of biological functions. Procedures for the quantitative analysis of FAEs include organic solvent extraction from biological matrices (e.g., blood), followed by purification and subsequent quantitation by liquid chromatography-mass spectrometry (LC/MS) or gas chromatography-mass spectrometry. During the validation process of a new method for LC/MS analysis of FAEs in biological samples, we observed unusually high levels of the FAE, palmitoylethanolamide (PEA), in blank samples that did not contain any biological material...
2017: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/28861206/comparison-of-pasteurized-autograft-prosthesis-composite-reconstruction-and-resection-hip-arthroplasty-for-periacetabular-tumors
#17
Seung Yong Lee, Dae-Geun Jeon, Wan Hyeong Cho, Won Seok Song, Chang-Bae Kong
BACKGROUND: Because of the high complication rate of anatomical reconstruction after periacetabular resection, the strategy of resection alone has been revisited. However, in terms of complications and functional outcome, whether resection hip arthroplasty (RHA) shows a superior result to that of pelvic ring reconstruction remains controversial. METHODS: We compared 24 RHAs and 16 pasteurized autograft-prosthesis composite (PPC) reconstructions regarding the complication rates, operative time, blood loss, and functional outcome...
September 2017: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/28858242/effect-of-processing-intensity-on-immunologically-active-bovine-milk-serum-proteins
#18
Tabea Brick, Markus Ege, Sjef Boeren, Andreas Böck, Erika von Mutius, Jacques Vervoort, Kasper Hettinga
Consumption of raw cow's milk instead of industrially processed milk has been reported to protect children from developing asthma, allergies, and respiratory infections. Several heat-sensitive milk serum proteins have been implied in this effect though unbiased assessment of milk proteins in general is missing. The aim of this study was to compare the native milk serum proteome between raw cow's milk and various industrially applied processing methods, i.e., homogenization, fat separation, pasteurization, ultra-heat treatment (UHT), treatment for extended shelf-life (ESL), and conventional boiling...
August 31, 2017: Nutrients
https://www.readbyqxmd.com/read/28856527/neonatal-outcomes-following-exposure-in-utero-to-fallout-from-chernobyl
#19
Maureen Hatch, Mark P Little, Alina V Brenner, Elizabeth K Cahoon, Valery Tereshchenko, Ludmyla Chaikovska, Igor Pasteur, Ilya Likhtarov, Andre Bouville, Victor Shpak, Olena Bolshova, Galyna Zamotayeva, Katherine Grantz, Liping Sun, Kiyohiko Mabuchi, Paul Albert, Mykola Tronko
Iodine 131 (I-131), the principal component of nuclear fallout from the Chernobyl accident, concentrates in the thyroid gland and may pose risks to fetal development. To evaluate this, neonatal outcomes following the accident in April of 1986 were investigated in a cohort of 2582 in utero-exposed individuals from northern Ukraine for whom estimates of fetal thyroid I-131 dose were available. We carried out a retrospective review of cohort members' prenatal, delivery and newborn records. The relationships of dose with neonatal anthropometrics and gestational length were modeled via linear regression with adjustment for potentially confounding variables...
August 30, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28846021/remembering-marcel-baltazard-great-researcher-and-the-french-president-of-pasteur-institute-of-iran
#20
Marjan Keypour, Manijeh Yousefi Behzadi, Ehsan Mostafavi
Dr. Marcel Baltazard (1908-1971), French scientist and former director of Pasteur Institute of Iran, is known in the international arena due to his research on the control of infectious diseases such as plague, rabies, relapsing fever, leprosy, smallpox and tuberculosis. Dr. Baltazard also played a significant role in the launch of vaccination against tuberculosis, cholera and smallpox. Dr. Baltazard's spent the first 13 years of academic life at Pasteur Institute of Casablanca, Morocco, and then 20 years at Pasteur Institute of Iran and over the last five years at Pasteur Institute of Paris...
August 2017: Archives of Iranian Medicine
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