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https://www.readbyqxmd.com/read/29346373/reconciling-pasteur-and-darwin-to-control-infectious-diseases
#1
Samuel Alizon, Pierre-Olivier Méthot
The continual emergence of new pathogens and the increased spread of antibiotic resistance in bacterial populations remind us that microbes are living entities that evolve at rates that impact public health interventions. Following the historical thread of the works of Pasteur and Darwin shows how reconciling clinical microbiology, ecology, and evolution can be instrumental to understanding pathology, developing new therapies, and prolonging the efficiency of existing ones.
January 18, 2018: PLoS Biology
https://www.readbyqxmd.com/read/29338336/changes-in-microbial-growth-carotenoids-and-water-soluble-tannin-content-of-ripe-persimmon-beverage-after-ultra-high-pressure-treatment
#2
Gi-Chang Kim, Sang-Bum Kim, Jin-Sook Kim, Kyung-Mi Kim, Song-Yi Choi
To avoid the loss of carotenoids and increasing the tannin content associated with pasteurization, we tested ultra-high pressure treatment of ripe persimmon beverage. We compared microbial counts (aerobic bacteria, coliforms, and mould), carotenoid contents, and water-soluble tannin contents between heat- and ultra-high pressure-treated beverages. No microbial contamination was detected after pasteurization or ultra-high pressure treatment at 400 MPa for more than 5 min. Ultra-high pressure treatment significantly prevented the reduction in carotenoids (lutein, zeaxanthin, β-cryptoxanthin, β-carotene, lycopene), with losses of 3...
January 1, 2018: Food Science and Technology International, Ciencia y Tecnología de Los Alimentos Internacional
https://www.readbyqxmd.com/read/29304316/best-practices-to-limit-contamination-of-donor-milk-in-a-milk-bank
#3
Elizabeth B Froh, Jill Vanderpool, Diane L Spatz
Human milk donated to a milk bank can become contaminated in a number of ways, but processes exist to eradicate pathogenic bacterial growth. Donor human milk may be cultured before or after pasteurization or both. The purpose of this article is to describe standard operations of the Mothers' Milk Bank of the Children's Hospital of Philadelphia, best practices to limit the bacterial contamination of donor human milk, and implications for future research.
January 2, 2018: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/29291220/sequencing-and-sequence-analysis-of-partial-nucleoprotein-n-gene-and-phylogenetic-analysis-of-rabies-virus-field-isolates-from-gujarat-state-india
#4
Dhaval H Vagheshwari, Bharat B Bhanderi, Rafyuddin A Mathakiya, Mayurdhvaj K Jhala
The present study was undertaken with an aim of characterization of rabies virus (genus Lyssavirus of the family Rhabdoviridae under the order Mononegavirales) by sequencing of partial nucleoprotein (N) gene of rabies virus and phylogenetic analysis to know the genotype and lineage of rabies virus present in Gujarat state of India. A total of 32 samples (18 brain samples and 14 saliva samples) were aseptically collected from live and dead animals (viz. dog, buffalo, cow, goat, donkey and hyena) for rabies virus detection...
September 2017: Virusdisease
https://www.readbyqxmd.com/read/29290393/genetic-characterization-of-listeria-monocytogenes-from-ruminant-listeriosis-from-different-geographical-regions-in-the-u-s
#5
Abbey J Steckler, Maria X Cardenas-Alvarez, Megan K Townsend Ramsett, Neil Dyer, Teresa M Bergholz
Listeria monocytogenes infections are an important disease of ruminants worldwide, causing encephalitis, septicemia, and abortions. Ruminant listeriosis can also pose a food safety risk due to the potential for L. monocytogenes to enter the food supply via the farm environment. Data on the genetic diversity of L. monocytogenes from ruminant clinical cases in the United States is limited. Our goal was to assess the genetic diversity of clinical listeriosis isolates from ruminants in the Upper Great Plains states, a population not well-studied, and compare this population to isolates from ruminants in New York State...
December 26, 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29287170/outcomes-associated-with-type-of-milk-supplementation-among-late-preterm-infants
#6
Rebecca Mannel, Jennifer D Peck
OBJECTIVE: To assess whether type of milk supplementation provided to breastfeeding late preterm infants was associated with hospital length of stay (LOS) or breastfeeding status at discharge. DESIGN: Retrospective chart review. SETTING: Tertiary care teaching hospital in the southern United States. PARTICIPANTS: Late preterm infants 35 0/7 to 36 6/7 weeks gestational age (N = 183) admitted to the mother-baby unit between November 1, 2014, and October 31, 2016...
December 26, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/29274959/short-communication-snapshot-of-industry-milk-hauling-practices-in-the-western-united-states
#7
Eva Kuhn, Lisbeth Meunier-Goddik, Joy G Waite-Cusic
The Pasteurized Milk Ordinance (PMO) mandates milk hauling sanitation and operational practices; however, the use of vague language (i.e., "as needed") and gaps in processes lead to variability in industry practices. Our aim was to characterize industry milk hauling practices and identify areas that may be an unexplained source of contamination in the dairy processing continuum, and communicate this information with industry to cultivate best practices. The objectives of this study were to (1) survey industry hauling sanitation and operation practices in the Pacific Northwest region of the United States, and (2) quantify microbial populations [aerobic plate count (APC), lactic acid bacteria, coliforms] on the internal surfaces of transfer hoses (tanker and receiving bay) to determine their potential contribution to the microbiological quality of raw milk...
December 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29249524/frequency-and-cost-of-vaccinations-administered-outside-minimum-and-maximum-recommended-ages-2014-data-from-6-sentinel-sites-of-immunization-information-systems
#8
Loren Rodgers, Lauren Shaw, Raymond Strikas, Beth Hibbs, JoEllen Wolicki, Cristina V Cardemil, Cindy Weinbaum
OBJECTIVE: To quantify vaccinations administered outside minimum and maximum recommended ages and to determine attendant costs of revaccination by analyzing immunization information system (IIS) records. STUDY DESIGN: We analyzed deidentified records of doses administered during 2014 to persons aged <18 years within 6 IIS sentinel sites (10% of the US population). We quantified doses administered outside of recommended ages according to the Advisory Committee on Immunization Practices childhood immunization schedule and prescribing information in package inserts, and calculated revaccination costs...
December 14, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29248213/effect-of-leaving-milk-trucks-empty-and-idle-for-6-h-between-raw-milk-loads
#9
Eva Kuhn, Lisbeth Meunier-Goddik, Joy G Waite-Cusic
The US Pasteurized Milk Ordinance (PMO) allows milk tanker trucks to be used repeatedly for 24 h before mandatory clean-in-place cleaning, but no specifications are given for the length of time a tanker can be empty between loads. We defined a worst-case hauling scenario as a hauling vessel left empty and dirty (idle) for extended periods between loads, especially in warm weather. Initial studies were conducted using 5-gallon milk cans (pilot-scale) as a proof-of-concept and to demonstrate that extended idle time intervals could contribute to compromised raw milk quality...
December 13, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29246196/a-two-month-follow-up-evaluation-testing-interventions-to-limit-the-emergence-and-spread-of-antimicrobial-resistant-bacteria-among-maasai-of-northern-tanzania
#10
Casey J Roulette, Mark A Caudell, Jennifer W Roulette, Robert J Quinlan, Marsha B Quinlan, Murugan Subbiah, Douglas R Call
BACKGROUND: In sub-Saharan Africa, efforts to control antimicrobial resistance (AMR) are aggravated by unregulated drug sales and use, and high connectivity between human, livestock, and wildlife populations. Our previous research indicates that Maasai agropastoralists-who have high exposure to livestock and livestock products and self-administer veterinary antibiotics-harbor antibiotic resistant Escherichia coli (E. coli). Here, we report the results of a public health intervention project among Maasai aimed at reducing selection and transmission of E...
December 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29240238/evaluation-of-microfiltration-and-heat-treatment-on-the-microbiological-characteristics-phenolic-composition-and-volatile-compounds-profile-of-pomegranate-juice-punica-granatum-l
#11
REVIEW
Antonio Colantuono, Paola Vitaglione, Nadia Manzo, Giuseppe Blaiotta, Immacolata Montefusco, Andrea Marrazzo, Fabiana Pizzolongo, Raffaele Romano
BACKGROUND: Since processing technology and storage may influence both sensory and nutritional value as well as the shelf-life of pomegranate juice (PJ), mild technologies based on microfiltration may be a promising alternative to heat treatments for fruit juices preservation. In this study, physico-chemical and microbiological properties of raw (RPJ), microfiltered (MPJ) and cloudy pasteurized PJ (PPJ) were compared over a period of 4 weeks. RESULTS: Data demonstrated that microfiltration was comparable to pasteurization in guarantying the microbiological stability of the juice avoiding spoilage of the final product...
December 14, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29236666/-louis-pasteur-and-claude-bernard-about-a-posthumous-controversy
#12
Patrice Debré
Claude Bernard and Louis Pasteur will meet on various occasions, scientific prizes were awarded by Claude Bernard to Louis Pasteur, Claude Bernard's lessons were followed by Louis Pasteur at the Faculty of Science or at the College de France, and friendly relationship were established. But the essential lies in a posthumous controversy where Claude Bernard, denying the role of microbes in the fermentation, seems to criticize Pasteur's assertions and, later, his method and vision. We shall report here the exchanges which concern these two scientists and, beyond that, the scientific approach...
2017: Biologie Aujourd'hui
https://www.readbyqxmd.com/read/29231157/plant-produced-subunit-vaccine-candidates-against-yellow-fever-induce-virus-neutralizing-antibodies-and-confer-protection-against-viral-challenge-in-animal-models
#13
Stephen Tottey, Yoko Shoji, R Mark Jones, Jessica A Chichester, Brian J Green, Konstantin Musiychuk, Huaxin Si, Slobodanka Manceva, Amy Rhee, Moneim Shamloul, Joey Norikane, Rosane C Guimarães, Elena Caride, Andrea N M R Silva, Marisol Simões, Patricia C C Neves, Renato Marchevsky, Marcos S Freire, Stephen J Streatfield, Vidadi Yusibov
Yellow fever (YF) is a viral disease transmitted by mosquitoes and endemic mostly in South America and Africa with 20-50% fatality. All current licensed YF vaccines, including YF-Vax® (Sanofi-Pasteur, France) and 17DD-YFV (Bio-Manguinhos, Brazil), are based on live attenuated virus produced in hens' eggs and have been widely used. The YF vaccines are considered safe and highly effective. However, a recent increase in demand for YF vaccines and reports of rare cases of YF vaccine-associated fatal adverse events have provoked interest in developing a safer YF vaccine that can be easily scaled up to meet this increased global demand...
December 11, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29231152/risk-factors-for-human-brucellosis-in-northern-tanzania
#14
Shama Cash-Goldwasser, Michael J Maze, Matthew P Rubach, Holly M Biggs, Robyn A Stoddard, Katrina J Sharples, Jo E B Halliday, Sarah Cleaveland, Michael C Shand, Blandina T Mmbaga, Charles Muiruri, Wilbrod Saganda, Bingileki F Lwezaula, Rudovick R Kazwala, Venance P Maro, John A Crump
Little is known about the epidemiology of human brucellosis in sub-Saharan Africa. This hampers prevention and control efforts at the individual and population levels. To evaluate risk factors for brucellosis in northern Tanzania, we conducted a study of patients presenting with fever to two hospitals in Moshi, Tanzania. Serum taken at enrollment and at 4-6 week follow-up was tested by Brucella microagglutination test. Among participants with a clinically compatible illness, confirmed brucellosis cases were defined as having a ≥ 4-fold rise in agglutination titer between paired sera or a blood culture positive for Brucella spp...
December 11, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29227994/low-cost-low-tech-snp-genotyping-tools-for-resource-limited-areas-plague-in-madagascar-as-a-model
#15
Cedar L Mitchell, Voahangy Andrianaivoarimanana, Rebecca E Colman, Joseph Busch, Heidie Hornstra-O'Neill, Paul S Keim, David M Wagner, Minoarisoa Rajerison, Dawn N Birdsell
BACKGROUND: Genetic analysis of pathogenic organisms is a useful tool for linking human cases together and/or to potential environmental sources. The resulting data can also provide information on evolutionary patterns within a targeted species and phenotypic traits. However, the instruments often used to generate genotyping data, such as single nucleotide polymorphisms (SNPs), can be expensive and sometimes require advanced technologies to implement. This places many genotyping tools out of reach for laboratories that do not specialize in genetic studies and/or lack the requisite financial and technological resources...
December 11, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29224876/effect-of-different-forage-types-on-the-volatile-and-sensory-properties-of-bovine-milk
#16
Hope Faulkner, Tom F O'Callaghan, Stephen McAuliffe, Deirdre Hennessy, Catherine Stanton, Maurice G O'Sullivan, Joseph P Kerry, Kieran N Kilcawley
The effect of 3 diets (grass, grass/clover, and total mixed ration) on the volatile and sensory properties of bovine milk was assessed over an entire lactation season. Little evidence was found of direct transfer of terpenes into raw milk from the different diets, and it is likely that the monocultures of ryegrass used with and without white clover were factors as these contained very few terpenes. Evidence of direct transfer of nonterpene volatiles from forage to the subsequent raw milks was probable; however, differences in the protein carbohydrate availability and digestion in the rumen appeared to have a greater contribution to volatile profiles...
December 7, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29223138/plant-expressed-fc-fusion-protein-tetravalent-dengue-vaccine-with-inherent-adjuvant-properties
#17
Mi Young Kim, Alastair Copland, Kaustuv Nayak, Anmol Chandele, Muhammad Shamsher Ahmed, Qibo Zhang, Gil Reynolds Diogo, Matthew John Paul, Sven Hofmann, Moon-Sik Yang, Yong-Suk Jang, Julian K-C Ma, Rajko Reljic
Dengue is a major global disease requiring improved treatment and prevention strategies. The recently licensed Sanofi-Pasteur Denvaxia vaccine does not protect children under the age of nine and additional vaccine strategies are thus needed to halt this expanding global epidemic. Here, we employed a molecular engineering approach and plant-expression to produce a humanised and highly immunogenic Poly-Immunoglobulin G Scaffold (PIGS) fused to the consensus dengue envelope protein III domain (cEDIII). The immunogenicity of this IgG Fc receptor targeted vaccine candidate was demonstrated in transgenic mice expressing human FcγRI/CD64, by induction of neutralising antibodies and evidence of cell-mediated immunity...
December 9, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/29221672/cost-and-use-of-pasteurized-donor-human-milk-at-a-children-s-hospital
#18
Diane L Spatz, Abbey C Robinson, Elizabeth B Froh
OBJECTIVE: To determine the cost and use of pasteurized donor human milk (PDHM) at a children's hospital with a strong human milk culture. DESIGN: A retrospective descriptive cohort study. SETTING: A children's hospital in the northeastern region of the United States. PARTICIPANTS: Infants (N = 281) younger than 1 year of age at the time of hospitalization who received PDHM between January 2011 and November 2014. Infants older than 1 year of age at the time of hospitalization were excluded from the study sample...
December 5, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/29216029/disparities-in-hospital-reported-breast-milk-use-in-neonatal-intensive-care-units-united-states-2015
#19
Ellen O Boundy, Cria G Perrine, Jennifer M Nelson, Heather C Hamner
Breast milk is the recommended nutrition for infants. For preterm infants, when mother's milk is not available, pasteurized donor milk is recommended (1). Non-Hispanic black mothers are at increased risk for having a preterm birth and for not breastfeeding (2,3); however, it is not known whether demographic disparities exist in the use of breast milk in neonatal intensive care units (NICUs). Data from CDC's 2015 Maternity Practices in Infant Nutrition and Care (mPINC) survey, which does not collect patient-level demographics, were linked to the 2011-2015 U...
December 8, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29212301/convergence-of-cancer-metabolism-and-immunity-an-overview
#20
REVIEW
Chi Van Dang, Jung-Whan Kim
Cancer metabolism as a field of research was founded almost 100 years ago by Otto Warburg, who described the propensity for cancers to convert glucose to lactate despite the presence of oxygen, which in yeast diminishes glycolytic metabolism known as the Pasteur effect. In the past 20 years, the resurgence of interest in cancer metabolism provided significant insights into processes involved in maintenance metabolism of non-proliferating cells and proliferative metabolism, which is regulated by proto-oncogenes and tumor suppressors in normal proliferating cells...
January 1, 2018: Biomolecules & Therapeutics
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