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https://www.readbyqxmd.com/read/28716893/which-dengue-vaccine-approach-is-the-most-promising-and-should-we-be-concerned-about-enhanced-disease-after-vaccination-there-is-only-one-true-winner
#1
Scott B Halstead
The scientific community now possesses information obtained directly from human beings that makes it possible to understand why breakthrough-enhanced dengue virus (DENV) infections occurred in children receiving Sanofi Pasteur's Dengvaxia tetravalent live attenuated vaccine and to predict the possibility of breakthrough-enhanced DENV infections following immunization with two other tetravalent live attenuated vaccines now in phase III testing. Based upon recent research, Dengvaxia, lacking DENV nonstructural protein antigens, did not protect seronegatives because it failed to raise a competent T-cell response and/or antibodies to NS1...
July 17, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28716892/which-dengue-vaccine-approach-is-the-most-promising-and-should-we-be-concerned-about-enhanced-disease-after-vaccination-questions-raised-by-the-development-and-implementation-of-dengue-vaccines-example-of-the-sanofi-pasteur-tetravalent-dengue-vaccine
#2
Bruno Guy
Dengue is a still-growing public health concern in many tropical and subtropical regions of the world. The development and implementation of an effective dengue vaccine in these regions is a high priority. This insight focuses on the expected characteristics of a safe and efficacious vaccine, referring to the clinical experience obtained during the development of the first tetravalent dengue vaccine from Sanofi Pasteur, now licensed in several endemic countries. Safety and efficacy data from both short- and long-term follow-up of large-scale efficacy studies will be discussed, as well as the next steps following vaccine introduction...
July 17, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28715202/antifouling-biomimetic-liquid-infused-stainless-steel-application-to-dairy-industrial-processing
#3
Sawsen Zouaghi, Thierry Six, Séverine Bellayer, Sona Moradi, Savvas G Hatzikiriakos, Thomas Dargent, Vincent Thomy, Yannick Coffinier, Christophe André, Guillaume Delaplace, Maude Jimenez
Fouling is a widespread and costly issue, faced by all food-processing industries. Particularly, in the dairy sector, where thermal treatments are mandatory to ensure product safety, heat-induced fouling represents up to 80% of the total production costs. Significant environmental impacts, due the massive consumption of water and energy, are also to deplore. Fouling control solutions are thus desperately needed, as they would lead to substantial financial gains, as well as tremendous progress toward eco-responsible processes...
July 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28713035/intracerebral-gene-therapy-in-children-with-mucopolysaccharidosis-type-iiib-syndrome-an-uncontrolled-phase-1-2-clinical-trial
#4
Marc Tardieu, Michel Zérah, Marie-Lise Gougeon, Jérome Ausseil, Stéphanie de Bournonville, Béatrice Husson, Dimitrios Zafeiriou, Giancarlo Parenti, Philippe Bourget, Béatrice Poirier, Valérie Furlan, Cécile Artaud, Thomas Baugnon, Thomas Roujeau, Ronald G Crystal, Christian Meyer, Kumaran Deiva, Jean-Michel Heard
BACKGROUND: Mucopolysaccharidosis type IIIB syndrome (also known as Sanfilippo type B syndrome) is a lysosomal storage disease resulting in progressive deterioration of cognitive acquisition after age 2-4 years. No treatment is available for the neurological manifestations of the disease. We sought to assess the safety and efficacy of a novel intracerebral gene therapy. METHODS: Local regulatory authorities in France allowed inclusion of up to four children in this phase 1/2 study...
July 13, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28711259/effect-of-dairy-product-environment-on-the-growth-of-bacillus-cereus
#5
E Tirloni, E Ghelardi, F Celandroni, C Bernardi, S Stella
pH is one of the most important parameters to manage bacterial replication in foodstuffs. In this study, the ability of 2 Bacillus cereus strains, one clinical human isolate (GPe2) and one isolate from a dairy products (D43), were investigated for the in vitro growth at different pH values (from 3.5 to 7.5) at 2 temperatures (15 and 37°C), showing their ability to grow from 5.5 to 7.5 and from 5.0 to 7.5, respectively. The ability of spores of these 2 microorganisms to germinate in different typologies of dairy products (unflavored yogurt, Taleggio cheese, mascarpone cheese, and raw and pasteurized milk) was also investigated by inoculating the spores and maintaining the products at 15°C...
July 12, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28710848/breaking-transmission-with-vaccines-the-case-of-tuberculosis
#6
Jesus Gonzalo-Asensio, Nacho Aguilo, Dessislava Marinova, Carlos Martin
Members of the Mycobacterium tuberculosis complex (MTBC) have evolved causing tuberculosis (TB) in different mammalian hosts. MTBC ecotypes have adapted to diverse animal species, with M. bovis being the most common cause of TB in livestock. Cattle-to-human transmission of M. bovis through ingestion of raw milk was common before introduction of the pasteurization process. TB in humans is mainly caused by M. tuberculosis. This bacterium is considered a genetically clonal pathogen that has coevolved with humans due to its ability to manipulate and subvert the immune response...
July 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/28706881/assessment-effects-of-resveratrol-on-human-telomerase-reverse-transcriptase-messenger-ribonucleic-acid-transcript-in-human-glioblastoma
#7
Azin Mirzazadeh, Majid Kheirollahi, Ehsan Farashahi, Fatemeh Sadeghian-Nodoushan, Mohammad Hasan Sheikhha, Behrouz Aflatoonian
BACKGROUND: Glioblastoma (GBM) is the most common and aggressive brain tumor, which has a poor prognosis despite the advent of different therapeutic strategies. There are numerous molecular biomarkers to contribute diagnosis, prognosis, and prediction of response to the current therapy in GBM. One of the most important markers that are potentially valuable is immortalization-specific or immortalization-associated marker named "hTERT messenger ribonucleic acid (mRNA)" the key subunit of telomerase enzyme, which is expressed in more than 85% of cancer cells, in spite of the majority of normal somatic cells...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28703961/effect-of-addition-of-wild-garlic-allium-ursinum-on-the-quality-of-kefirs-from-sheep-s-milk
#8
Agata Znamirowska, Katarzyna Szajnar, Przemysław Rożek, Dorota Kalicka, Piotr Kuźniar, Paweł Hanus, Krzysztof Kotula, Marcin Obirek, Maciej Kluz
BACKGROUND: Sheep’s milk has a high content of total solids, which qualifies it as a very good raw material for the production of fermented milk drinks. Currently, there are commercially produced kefirs and yogurts from sheep’s milk in the countries of the Mediterranean region. The growing interest in the consumption of these products is justified not only by their taste merits, but also because of their health-promoting proper- ties. The aim of the present study was to determine the effect of the addition of 1% of lyophilized wild garlic powder on the properties of kefirs from sheep’s milk...
April 2017: Acta Scientiarum Polonorum. Technologia Alimentaria
https://www.readbyqxmd.com/read/28702375/a-single-nucleotide-polymorphism-is-involved-in-regulation-of-growth-and-spore-formation-of-bacillus-anthracis-pasteur-ii-strain
#9
Xudong Liang, Jin Zhu, Zhongzhi Zhao, Feng Zheng, Enmin Zhang, Jianchun Wei, Yon Ji, Yinduo Ji
Anthrax toxins and capsules, which are encoded by genes located on pXO1 and pXO2, respectively, are major virulence factors of Bacillus anthracis. Our previous studies demonstrated that exposure to high-temperatures is unable to abolish the pXO1 plasmid of the Pasteur II strain, but the growth of the strain was obviously slower than that of the Sterne strain and wild-type virulent strain. To elucidate a potential regulatory mechanism of slowing growth, we employed comparative genome and bioinformatic analysis and revealed a unique SNP (G to T) at the 143135 bp position in pXO1 that is possibly involved in the mediation of growth of Pasteur II...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28702019/functional-resilience-and-response-to-a-dietary-additive-kefir-in-models-of-foregut-and-hindgut-microbial-fermentation-in-vitro
#10
Gabriel de la Fuente, Eleanor Jones, Shann Jones, Charles J Newbold
Stability in gut ecosystems is an important area of study that impacts on the use of additives and is related with several pathologies. Kefir is a fermented milk drink made with a consortium of yeast and bacteria as a fermentation starter, of which the use as additive in companion and livestock animals has increased in the last few years. To investigate the effect of kefir milk on foregut and hindgut digestive systems, an in vitro approach was followed. Either rumen fluid or horse fecal contents were used as a microbial inoculate and the inclusion of kefir (fresh, autoclaved, or pasteurized) was tested...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28691975/stability-of-cortisol-and-cortisone-in-human-breast-milk-during-holder-pasteurization
#11
Bibian van der Voorn, Marita de Waard, Lisette R Dijkstra, Annemieke C Heijboer, Joost Rotteveel, Johannes B van Goudoever, Martijn J J Finken
Human donor milk is the feeding of choice for preterm infants, when own mother's milk is not available. Holder pasteurization is necessary to secure the safety of donor milk, although it can affect milk quality by reduction of nutritional and bioactive components. Recently, research has focused on the potential role of breast-milk glucocorticoids for infant development. At this moment, it is unknown whether pasteurization affects milk glucocorticoid levels. Therefore, we assessed whether Holder pasteurization, the most frequently used method nowadays, reduces breast-milk cortisol and cortisone levels, using breast milk samples from 30 women who delivered at term...
July 6, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28691218/safety-of-a-pasteurized-plasma-derived-factor-viii-and-von-willebrand-factor-concentrate-analysis-of-33-years-of-pharmacovigilance-data
#12
Peter Kouides, Kathrin Wawra-Hehenberger, Anna Sajan, Henry Mead, Toby Simon
BACKGROUND: Haemate-P/Humate-P (Humate-P) is a pasteurized human plasma-derived concentrate containing both Factor VIII and von Willebrand factor for treatment of hemophilia A and von Willebrand disease (VWD). STUDY DESIGN AND METHODS: We analyzed the safety of Humate-P based on more than 33 years of postmarketing pharmacovigilance data, representing an estimated exposure of approximately 25,000 patient-years. The analysis comprises reports of potential adverse drug reactions (ADRs) from all sources, reported as part of routine pharmacovigilance at CSL Behring...
July 10, 2017: Transfusion
https://www.readbyqxmd.com/read/28686621/risk-of-bias-and-confounding-of-observational-studies-of-zika-virus-infection-a-scoping-review-of-research-protocols
#13
Ludovic Reveiz, Michelle M Haby, Ruth Martínez-Vega, Carlos E Pinzón-Flores, Vanessa Elias, Emma Smith, Mariona Pinart, Nathalie Broutet, Francisco Becerra-Posada, Sylvain Aldighieri, Maria D Van Kerkhove
INTRODUCTION: Given the severity and impact of the current Zika virus (ZIKV) outbreak in the Americas, numerous countries have rushed to develop research studies to assess ZIKV and its potential health consequences. In an effort to ensure that studies are comprehensive, both internally and externally valid, and with reliable results, the World Health Organization, the Pan American Health Organization, Institut Pasteur, the networks of Fiocruz, the Consortia for the Standardization of Influenza Seroepidemiology (CONSISE) and the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) have generated six standardized clinical and epidemiological research protocols and questionnaires to address key public health questions on ZIKV...
2017: PloS One
https://www.readbyqxmd.com/read/28686461/a-large-meta-analysis-of-the-global-prevalence-rates-of-s-aureus-and-mrsa-contamination-of-milk
#14
Qianting Ou, Junli Zhou, Dongxin Lin, Chan Bai, Ting Zhang, Jialing Lin, Haoqu Zheng, Xiaojie Wang, Jiaping Ye, Xiaohua Ye, Zhenjiang Yao
Past reports have indicated a high prevalence of milk contaminated with Staphylococcus aureus (S. aureus) and methicillin-resistant Staphylococcus aureus (MRSA), but the pooled prevalence rates of S. aureus and MRSA in pasteurized and boiled cow's milk, raw cow's milk, and raw Caprinae milk (raw sheep's milk and raw goat's milk) and across different periods, continents, economic conditions and purchase locations remain inconsistent. We searched relevant articles published in PubMed, EMBASE, and Web of Science before July 2016...
July 7, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28683530/quantitative-analysis-of-milk-derived-micrornas-and-microbiota-during-the-manufacturing-and-ripening-of-soft-cheese
#15
Sangnam Oh, Mi Ri Park, Sangdon Ryu, Brighton E Maburutse, Ji-Uk Kim, Younghoon Kim
MicroRNAs (miRNAs) are abundant in bovine milk and milk derived from other livestock, and they have functional roles in infants and in the secretion process of mammary glands. However, few studies have evaluated miRNAs in dairy processes, such as during cheese making and ripening. Thus, we investigated the characteristics of milk-derived miRNAs during the manufacturing and ripening of Camembert cheese as well as the microbiota present using quantitative reverse transcription polymer chain reaction (RT-qPCR) and 16S rRNA pyrosequencing, respectively...
July 7, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28681026/a-seasonal-study-for-determination-of-aflatoxin-m1-level-in-dairy-products-in-iranshahr-iran
#16
N Sohrabi, H Gharahkoli
BACKGROUND AND PURPOSE: Aflatoxin M1, in milk and dairy products, is classified by the International Agency for Research on Cancer as human carcinogens (class 2B). The aim of this study was to evaluate aflatoxin M1 contamination level in dairy products from Iranshahr city, Iran, using ELISA technique. MATERIALS AND METHODS: In our study, 87 samples of milk, white cheese, yoghurt, and butter were collected in different seasons and after preparation, were analyzed by ELISA technique...
September 2016: Advances in Medical Mycology (Iran)
https://www.readbyqxmd.com/read/28680645/polychlorinated-biphenyls-pcbs-residues-in-commercial-pasteurized-cows-milk-in-tehran-iran
#17
Reza Ahmadkhaniha, Ramin Nabizadeh Nodehi, Noushin Rastkari, Hassan Mohammadi Aghamirloo
BACKGROUND: To date, despite the facts that pasteurized milk is the most consumed dairy product in Iran and its consumption has increased almost two fold during the last 10 years, no data are available concerning the concentrations of polychlorinated biphenyls (PCBs) in commercial cow milk in Iran market. METHODS: This study designed to determine the levels of PCBs in these products and to assess population exposure to PCBs by estimating the daily intakes. Pasteurized cows' milk samples (10 brands) were collected from local markets at two different seasons and analyzed using sensitive and reliable methods...
2017: Journal of Environmental Health Science & Engineering
https://www.readbyqxmd.com/read/28674588/four-years-into-the-indian-ocean-field-epidemiology-training-programme
#18
Ariane Halm, Thomas Seyler, Sainda Mohamed, Saindou Ben Ali Mbaé, Armand Eugène Randrianarivo-Solofoniaina, Maherisoa Ratsitorahina, Ram Nundlall, Shahina Aboobakar, Jastin Bibi, Laurent Filleul, Patrice Piola, Harimahefa Razafimandimby, Harena Rasamoelina, Marta Valenciano, Alain Moren, Eric Cardinale, Richard Lepec, Loïc Flachet
INTRODUCTION: Following the 2005-6 chikungunya outbreak, a project to strengthen regional Public Health preparedness in the Indian Ocean was implemented. It includes the Comoros, Madagascar, Mauritius, Reunion (France) and Seychelles. A Field Epidemiology Training Programme (FETP-OI) was started in 2011 to develop a pool of well-trained intervention epidemiologists. METHODS: The FETP-OI consists of two years of supervised, learning-by-doing, on-the-job training at national sites involved in disease surveillance and response...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28668530/development-of-a-rapid-mitochondrial-dna-extraction-method-for-species-identification-in-milk-and-milk-products
#19
J Liao, Y F Liu, L Yang, F P Li, A M Sheppard
Isolation of mitochondrial DNA (mtDNA) from milk offers an effective way to monitor aspects of quality control and traceability to ensure food safety. A few methods of DNA isolation from milk have been reported, but many of them are time consuming and expensive. Here, we report a rapid, simple, and efficient method of mtDNA extraction from raw and processed milk (pasteurized, retorted, and UHT milk) to generate substrate for analysis using any PCR analysis platform. Various techniques used for the separation of mitochondria were explored and combined with a sodium dodecyl sulfate method for mtDNA extraction from raw and processed milk...
June 28, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28659718/pasteurized-autograft-prosthesis-composite-reconstruction-may-not-be-a-viable-primary-procedure-for-large-skeletal-defects-after-resection-of-sarcoma
#20
Seung Yong Lee, Dae-Geun Jeon, Wan Hyeong Cho, Won Seok Song, Chang-Bae Kong, Bum Suk Kim
BACKGROUND: Among various types of composite biological reconstruction, pasteurized autograft-prosthesis composite (PPC) is popular when allograft is unavailable. Previous limited cohort study indicated result comparable to tumor prosthesis. However, as case number and follow-up increase, we experienced more complications than anticipated. We questioned the usefulness of PPC as a viable reconstructive option. METHODS: We reviewed 142 PPCs and analyzed overall and location-related survival and factors associated with the failure of PPC...
2017: Sarcoma
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