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Modic 1 and antibiotic therapy

Gaurav Gupta, Peter Jarzem, Sean Meredith, Mohan Radhakrishna, Markus Besemann, Maria Francisca Elgueta, Roshanak Charghi, Jeffrey Chankowsky
PURPOSE: To determine the clinical effect of antibiotic treatment for patients with low back pain and Modic 1 changes. METHODS: This is a retrospective case series of patients treated at the Canadian Forces Health Services Centre in Ottawa and the McGill University Health Centre. Where available, pain, functional, and imaging outcomes in 11 patients treated between 2013 and 2015 were analyzed to determine effect of antibiotic treatment for patients with low back pain and associated Modic 1 changes on magnetic resonance imaging...
October 2017: U.S. Army Medical Department Journal
Stefan Dudli, Ellen Liebenberg, Sergey Magnitsky, Steve Miller, Sibel Demir-Deviren, Jeffrey C Lotz
Modic type I change (MC1) are vertebral bone marrow lesions adjacent to degenerated discs that are specific for discogenic low back pain. The etiopathogenesis is unknown, but occult discitis, in particular with Propionibacteria acnes (P. acnes), has been suggested as a possible etiology. If true, antibiotic therapy should be considered for patients with MC1. However, this hypothesis is controversial. While some studies report up to 40% infection rate in herniated discs, others fail to detect infected discs and attribute reports of positive cultures to contamination during sampling procedure...
August 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Stephane Aunoble, David Hoste, Peter Donkersloot, Frederic Liquois, Yann Basso, Jean-Charles Le Huec
INTRODUCTION: Spondylolysis and spondylolisthesis grade 0, 1, and 2 are mainly asymptomatic but with aging process and different factors some back pain can occur and lead to chronic low back pain. The conservative treatment with physiotherapy and steroid injection is the gold standard but in some cases is not efficient enough and a surgical treatment is proposed. OBJECTIVES: The goal of this study is to propose a new technique to treat grade 0, 1, and 2 spondylolisthesis with an anterior video-assisted fusion and stabilization...
October 2006: Journal of Spinal Disorders & Techniques
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