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Jiao Mo, Renhua Yang, Fan Li, Xiaochao Zhang, Bo He, Yue Zhang, Peng Chen, Zhiqiang Shen
BACKGROUND: Scutellarin is the major constituent responsible for the clinical benefits of Erigeron breviscapus (Vant.) Hand.-Mazz which finds a long history of ethnopharmacological use in Traditional Chinese Medicine. Scutellarin as a pure compound is now under investigation for its protections against various tissue injuries. PURPOSE: This study aims to examine the effects of scutellarin on oxidative stress-induced vascular endothelial dysfunction and endothelial cell damage, and then to evaluate the therapeutic efficacy of scutellarin in preventing atherosclerosis in rats...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Yun-Xi Li, Bao-Zhen Li, Da-Zun Yan
Dyslipidemia in patients with hypercholesterolemia has been recently linked to increased human cathelicidin LL-37 (LL-37) serum concentration. We tested a hypothesis that upregulated expression of LL-37 gene in peripheral blood leucocytes is involved in dyslipidemia in patients with hypercholesteremia. Patients with hypercholesterolemia were used in the study. Expression of LL-37 and human glyceraldehyde-3-phosphate dehydrogenase in peripheral blood leucocytes were quantified by real-time RT-PCR. Serum LL-37 concentration was estimated by enzyme-linked immunosorbent assay...
April 11, 2018: Molecular and Cellular Biochemistry
Gholamreza Shahsavari, Amir Raoufi, Aram Toolabi, Nahid Hosseninejadmir, Hassan Ahmadvand, Mehdi Safariebrahimsarabie
BACKGROUND: The major aim of this study was evaluating the effect of atorvastatin treatment on thiobarbituric acid reactive substances (TBARS), ferric reducing the ability of plasma (FRAP), small dense low-density lipoprotein cholesterol (sdLDL) and lipid profile in coronary artery disease (CAD) patients. METHODS: This study was carried out on 83 patients with angiographically proven coronary artery stenosis (52 men and 31 women) at Shahid Madani Hospital, Khorramabad, Iran, in 2015...
November 2017: ARYA Atherosclerosis
Csilla Viczenczova, Branislav Kura, Tamara Egan Benova, Chang Yin, Rakesh C Kukreja, Jan Slezak, Narcis Tribulova, Barbara Szeiffova Bacova
Radiation of the chest during cancer therapy is deleterious to the heart, mostly due to oxidative stress and inflammation related injury. A single sub-lethal dose of irradiation has been shown to result in compensatory up-regulation of the myocardial connexin-43 (Cx43), activation of the protein kinase C (PKC) signaling along with the decline of microRNA (miR)-1 and an increase of miR-21 levels in the left ventricle (LV). We investigated whether drugs with antioxidant, anti-inflammatory or vasodilating properties, such as aspirin, atorvastatin, and sildenafil, may affect myocardial response in the LV and right ventricle (RV) following chest irradiation...
April 10, 2018: International Journal of Molecular Sciences
Katarina Bimbova, Maria Bacova, Alexandra Kisucka, Jaroslav Pavel, Jan Galik, Peter Zavacky, Martin Marsala, Andrea Stropkovska, Jana Fedorova, Stefania Papcunova, Jana Jachova, Nadezda Lukacova
The aim of our study was to limit the inflammatory response after a spinal cord injury (SCI) using Atorvastatin (ATR), a potent inhibitor of cholesterol biosynthesis. Adult Wistar rats were divided into five experimental groups: one control group, two Th9 compression (40 g/15 min) groups, and two Th9 compression + ATR (5 mg/kg, i.p.) groups. The animals survived one day and six weeks. ATR applied in a single dose immediately post-SCI strongly reduced IL-1β release at 4 and 24 h and considerably reduced the activation of resident cells at one day post-injury...
April 7, 2018: International Journal of Molecular Sciences
Z-W Zeng, Y-N Zhang, W-X Lin, W-Q Zhang, R Luo
OBJECTIVE: Non-cardiac surgery is associated with perioperative cerebral complications (delirium, postoperative cognition dysfunction, stroke). While rare, these complications can lead to disabilities and deaths. Information is ambiguous as to whether pharmacological preoperative treatment exerts neuroprotection. We wished to systematically assess potential modulation by statins, lidocaine, ketamine or magnesium sulfate of the relative risk of cerebral complications in noncardiac surgery...
March 2018: European Review for Medical and Pharmacological Sciences
Kenji Momo, Akiko Takagi, Atsuko Miyaji, Masayoshi Koinuma
PURPOSE: This study aimed to determine the frequency and risk factors for statin-induced interstitial pneumonia (IP). METHOD: We conducted a retrospective cohort study using a large Japanese health insurance claims database. We determined the statin-induced IP incidence in patients treated with statins for hyperlipidemia (n = 194,814) with 12-month screening and 3-month observation periods. Statin-induced IP was defined as: (1) diagnosis with IP (ICD-10 codes: J70...
April 5, 2018: Pulmonary Pharmacology & Therapeutics
Lotte Kaasenbrood, Kausik K Ray, S Matthijs Boekholdt, Yvo M Smulders, John C LaRosa, John J P Kastelein, Yolanda van der Graaf, Johannes A N Dorresteijn, Frank L J Visseren
OBJECTIVE: In statin-treated patients with stable coronary artery disease (CAD), residual risk of cardiovascular events is partly explained by plasma levels of low-density lipoprotein cholesterol (LDL-C). This study aimed to estimate individual benefit of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition in CAD patients already treated with high-dose statin. METHODS: Individual lifetime benefit was estimated in months gain free of stroke or myocardial infarction (MI) until age 80 years...
April 5, 2018: Heart: Official Journal of the British Cardiac Society
Rawabi Aljadani, Mohammed Aseeri
OBJECTIVE: A cross-sectional study was performed from February to May 2015, to estimate the prevalence of drug-drug interactions in geriatric patients at the ambulatory care pharmacy at King Abdul-Aziz Medical City in Jeddah, Saudi Arabia. RESULTS: A total of 310 patients were included, with a mean age (± SD) of 73.78 ± 6.96, and 48.70% were female. The overall prevalence of DDIs of all categories was 90.64%. Category B DDIs was 55.80%, category C DDIs 87...
April 5, 2018: BMC Research Notes
Antonio J Vallejo-Vaz, Rana Fayyad, S Matthijs Boekholdt, G Kees Hovingh, John J Kastelein, Shari Melamed, Philip Barter, David D Waters, Kausik K Ray
Background -Mendelian randomization data suggest genetic determinants of lifetime higher triglyceride-rich lipoprotein-cholesterol (TRL-C) are causally related to cardiovascular disease and therefore a potential therapeutic target. The relevance of TRL-C among patients receiving statins is unknown. We assessed the relationship between TRL-C and cardiovascular risk, and whether this risk was modifiable among patients receiving statins in the TNT trial. Methods -Patients with coronary heart disease [CHD] and LDL-C 130-250mg/dL entered an 8-week run-in phase with atorvastatin 10mg/day (ATV10)...
April 4, 2018: Circulation
Ioanna Mylonaki, Elisabeth Allain, Francesco Strano, Eric Allémann, Jean-Marc Corpataux, Paolo Meda, Olivier Jordan, Florence Delie, Anne-Laure Rougemont, Jacques-Antoine Haefliger, François Saucy
OBJECTIVES: Open arterial revascularization using venous segments is frequently associated with the development of intimal hyperplasia (IH), leading to severe restenosis and graft failure. The lack of treatment to prevent this pathology is a major problem. Therefore, we generated a new porcine model, which closely mimics the clinical development of human IH, to test the therapeutic potential of candidate drugs. METHODS: A patch of jugular vein was sutured to the right common carotid artery of pigs, to expose the vein to haemodynamic conditions of the arterial bed...
March 30, 2018: Interactive Cardiovascular and Thoracic Surgery
Sophie Nguyen, Sai Yee Chuah, Eric Fontas, Abdallah Khemis, Anjali Jhingan, Steven Tien Guan Thng, Thierry Passeron
No abstract text is available yet for this article.
April 4, 2018: JAMA Dermatology
Henrique Budib Dorsa Pontes, José Carlos Dorsa Vieira Pontes, Euler de Azevedo Neto, Giovanna Serra da Cruz Vendas, João Victor Cunha Miranda, Letícia do Espírito Santos Dias, João Victor Durães Gomes Oliva, Murilo Henrique Martins de Almeida, Ian de Oliveira Chaves, Tricia Luna Sampaio, Carlos Henrique Marques Dos Santos, Doroty Mesquita Dourado
INTRODUCTION: Reperfusion injury leads to systemic morphological and functional pathological alterations. Some techniques are already estabilished to attenuate the damage induced by reperfusion. Ischemic preconditioning is one of the standard procedures. In the last 20 years, several experimental trials demonstrated that the ischemic postconditioning presents similar effectiveness. Recently experimental trials demonstrated that statins could be used as pharmacological preconditioning...
January 2018: Brazilian Journal of Cardiovascular Surgery
Barbara Lettiero, Maria Inasu, Siker Kimbung, Signe Borgquist
Apart from the relevant lipid-lowering effects, statins have demonstrated significant, although heterogeneous, anti-tumor activities in preventing breast cancer (BC) progression. To characterize the critical pathways behind the diverse responses to therapy, we investigated statin-induced changes in regulation of lipid metabolism and abundance of neutral lipid-containing cytoplasmic lipid droplets (LDs) in BC cells displaying different sensitivity to atorvastatin. Following atorvastatin treatment, accumulated LD levels inversely mirrored the marginal anti-proliferative effects in a dose and time-dependent manner in the less-sensitive BC cells...
April 3, 2018: Scientific Reports
Bilal Khokhar, Linda Simoni-Wastila, Julia F Slejko, Eleanor Perfetto, Min Zhan, Gordon S Smith
Background: Traumatic brain injury (TBI) is a significant public health concern for older adults. Small-scale human studies have suggested pre-TBI statin use is associated with decreased in-hospital mortality following TBI, highlighting the need for large-scale translational research. Objective: To investigate the relationship between pre-TBI statin use and in-hospital mortality following TBI. Methods: A retrospective study of Medicare beneficiaries 65 and older hospitalized with a TBI during 2006 to 2010 was conducted to assess the impact of pre-TBI statin use on in-hospital mortality following TBI...
December 2017: Journal of Pharmacy Technology: JPT: Official Publication of the Association of Pharmacy Technicians
Junya Ako, Kiyoshi Hibi, Ken Kozuma, Katsumi Miyauchi, Yoshihiro Morino, Toshiro Shinke, Kenichi Tsujita, Kiyoko Uno, Yumiko Kawabata, Takafumi Hiro
BACKGROUND: Serial intravascular ultrasound (IVUS) imaging can be used to evaluate the effect of cholesterol-lowering on coronary atheroma progression and plaque volume, with evidence of potential incremental effects with more aggressive lipid-lowering treatments. Alirocumab is a highly specific, fully human monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9). This study will investigate the effect of alirocumab on coronary artery plaque volume in Japanese patients with a recent acute coronary syndrome (ACS) and hypercholesterolemia while on stable statin therapy...
March 29, 2018: Journal of Cardiology
Jun Peng, Huairu Tian, Qiuzheng Du, Xuanhong Hui, Hua He
Graphene oxide (GO), nanosized Fe3 O4 and zeolite imidazolate framework-8 (ZIF-8) were hybridized as a multifunctional sorbent for use in microextraction. The sorbent was characterized by SEM, TEM, XRD and FTIR. The composite is porous, has a high specific surface (> 600 m2 ·g-1 ) and is paramagnetic. The GO sheets are shown to act as carriers for the Fe3 O4 nanoparticles and ZIF-8. The composite is a viable material for the preconcentration of atorvastatin and simvastatin from urine prior to their determination by HPLC with PDA detection...
January 27, 2018: Mikrochimica Acta
Wentao Qi, Demao Cao, Yucheng Li, Aijun Peng, Youwei Wang, Kai Gao, Cunshan Tao, Yongkang Wu
Objective: Aneurysmal subarachnoid hemorrhage (SAH) is a severe cerebrovascular disease with very poor prognosis. The aim of this study was to evaluate the protective effects of atorvastatin on early brain injury (EBI) after SAH using a perforation SAH model. Methods: Male Sprague-Dawley rats were randomly divided into four groups: the sham group, the SAH group (model group), SAH + 10 mg·kg-1 ·d-1 atorvastatin (low atorvastatin group), and SAH + 20 mg·kg-1 ·d-1 atorvastatin (high atorvastatin group). Atorvastatin was administered orally by gastric gavage for 15 days before operation...
March 28, 2018: Bioscience Reports
Amirhossein Sahebkar, Luis E Simental-Mendía, Dimitri P Mikhailidis, Matteo Pirro, Maciej Banach, Cesare R Sirtori, Massimiliano Ruscica, Željko Reiner
BACKGROUND: Statins are well-established low-density lipoprotein cholesterol-lowering drugs. Elevated apolipoprotein CIII (Apo CIII) levels are associated with elevated triglyceride-rich particles, which are also considered to be a possible risk factor for cardiovascular disease. OBJECTIVE: The aim of this meta-analysis of randomized placebo-controlled clinical trials was to assess the effect of statins on Apo CIII concentrations. METHODS: Randomized placebo-controlled trials investigating the impact of statin treatment on cholesterol lowering that include lipoprotein measurement were searched in PubMed, MEDLINE, Scopus, Web of Science, and Google Scholar databases (up to July 31, 2017)...
February 1, 2018: Journal of Clinical Lipidology
Stefania Tacconelli, Melania Dovizio, Luigia Di Francesco, Alessandra Meneguzzi, Ilaria D'Agostino, Virgilio Evangelista, Stefano Manarini, Marta L Capone, Linda Grossi, Ettore Porreca, Concetta Di Febbo, Annalisa Bruno, Patrizia Ballerini, Giacomo Levantesi, Cristiano Fava, Pietro Minuz, Paola Patrignani
We studied the influence of cardiovascular(CV) risk factors, previous CV events, and co-treatments with preventive medicines, on residual platelet thromboxane(TX)B2 production in 182 patients chronically treated with enteric coated(EC)-aspirin(100mg/day). The response to aspirin was also verified by assessing arachidonic acid-induced platelet aggregation and urinary 11-dehydro-TXB2 levels. Residual serum TXB2 levels exceeded the upper limit value for an adequate aspirin response in 14% of individuals. This phenomenon was detected at 12h after dosing with aspirin...
March 25, 2018: Clinical Pharmacology and Therapeutics
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