keyword
MENU ▼
Read by QxMD icon Read
search

Atorvastatin

keyword
https://www.readbyqxmd.com/read/28214881/attenuation-of-low-ambient-temperature-induced-myocardial-hypertrophy-by-atorvastatin-via-promoting-bcl-2-expression
#1
Jing Liang, Kun Yin, Xuefeng Cao, Zhenbo Han, Qi Huang, Lai Zhang, Wenya Ma, Fengzhi Ding, Chongwei Bi, Dan Feng, Zhenwei Pan, Yu Liu
BACKGROUND/AIMS: It is well documented that myocardial hypertrophy is associated with low ambient temperature. Atorvastatin (Atv) has been shown to protect against atherosclerosis, cardiac fibrosis, ischemia/reperfusion injury, etc. In this study, we aim to determine whether atorvastatin is effective in the treatment of myocardial hypertrophy induced by cold exposure and to shed light on underlying mechanism. METHODS: The mice aged 4-week were randomized to Control (Ctl) group (raised at room temperature), Cold group (raised at 3-5ºC) and Atv treatment group (raised at 3-5ºC followed by 10mg/kg/day Atv infusion)...
January 24, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28209758/atorvastatin-decreases-hbx-induced-phospho-akt-in-hepatocytes-via-p2x-receptors
#2
Aram Ghalali, Javier Martin-Renedo, Johan Hogberg, Ulla Stenius
: Hepatocellular carcinoma (HCC) is rated as the fifth most common malignancy and third in cancer related deaths worldwide. Statins, HMG-CoA reductase inhibitors, are potent cholesterol lowering drugs and recent epidemiological evidence suggests that statins prevent aggressive HCC development. Previous experiments revealed that statins downregulate phosphorylated Akt (pAkt). Here, it is demonstrated that atorvastatin decreases nuclear pAkt levels in pancreatic and lung cancer cell lines within minutes and this rapid effect is mediated by the purinergic P2X receptors...
February 16, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28208058/monitoring-of-macrophage-accumulation-in-statin-treated-atherosclerotic-mouse-model-using-sodium-iodide-symporter-imaging-system
#3
Ran Ji Yoo, Min Hwan Kim, Sang-Keun Woo, Kwang Il Kim, Tae Sup Lee, Yang-Kyu Choi, Joo Hyun Kang, Sang Moo Lim, Yong Jin Lee
INTRODUCTION: Macrophages play a key role in atherosclerotic plaque formation in atherosclerosis, but its detailed understanding has poorly investigated until now. Thus, we sought to demonstrate a noninvasive technique for macrophage tracking to atherosclerotic lesions in apolipoprotein E(-/-)(ApoE(-/-)) mice with an imaging system based on sodium iodide symporter (NIS) gene coupled with (99m)Tc-single-photon emission computed tomography (SPECT). METHODS AND RESULTS: Macrophage cells (RAW264...
January 25, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28207527/zhibitai-and-low-dose-atorvastatin-reduce-blood-lipids-and-inflammation-in-patients-with-coronary-artery-disease
#4
Yuhong Zhao, Ran Peng, Wang Zhao, Qiong Liu, Yuan Guo, Shuiping Zhao, Danyan Xu
BACKGROUND: Atorvastatin decreases blood lipids but is associated with side effects. Zhibitai is a traditional Chinese medicine used to treat blood lipid disorders. The objective of this study is to evaluate the lipid-lowering effect, antiinflammatory effect, and adverse events of zhibitai combined to atorvastatin in patients with coronary heart diseases (CHDs). METHODS: Patients with CHD (n = 150) were randomized to: zhibitai 480 mg + atorvastatin 10 mg (ZA10 group), atorvastatin 20 mg (A20 group), and atorvastatin 40 mg (A40 group)...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28207072/synergistic-chemopreventive-effects-of-nobiletin-and-atorvastatin-on-colon-carcinogenesis
#5
Xian Wu, Mingyue Song, Peiju Qiu, Kanyasiri Rakariyatham, Fang Li, Zili Gao, Xiaokun Cai, Minqi Wang, Fei Xu, Jinkai Zheng, Hang Xiao
No abstract text is available yet for this article.
February 16, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28205568/luman-contributes-to-brefeldin-a-induced-prion-protein-gene-expression-by-interacting-with-the-erse26-element
#6
Marc-André Déry, Andréa C LeBlanc
The cellular prion protein (PrP) is essential for transmissible prion diseases, but its exact physiological function remains unclear. Better understanding the regulation of the human prion protein gene (PRNP) expression can provide insight into this elusive function. Spliced XBP1 (sXBP1) was recently shown to mediate endoplasmic reticulum (ER) stress-induced PRNP expression. In this manuscript, we identify Luman, a ubiquitous, non-canonical unfolded protein response (UPR), as a novel regulator of ER stress-induced PRNP expression...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28196119/correction-atorvastatin-improves-ventricular-remodeling-after-myocardial-infarction-by-interfering-with-collagen-metabolism
#7
Karla Reichert, Helison Rafael Pereira do Carmo, Anali Galluce Torina, Daniela Diógenes de Carvalho, Andrei Carvalho Sposito, Karlos Alexandre de Souza Vilarinho, Lindemberg da Mota Silveira-Filho, Pedro Paulo Martins de Oliveira, Orlando Petrucci
[This corrects the article DOI: 10.1371/journal.pone.0166845.].
2017: PloS One
https://www.readbyqxmd.com/read/28192516/correction-atorvastatin-losartan-and-captopril-lead-to-upregulation-of-tgf-%C3%AE-and-downregulation-of-il-6-in-coronary-artery-disease-and-hypertension
#8
Zahra Sepehri, Mohammad Masoumi, Nazanin Ebrahimi, Zohre Kiani, Ali Akbar Nasiri, Farhad Kohan, Mahmood Sheikh Fathollahi, Mohammad Kazemi Arababadi, Gholamreza Asadikaram
[This corrects the article DOI: 10.1371/journal.pone.0168312.].
2017: PloS One
https://www.readbyqxmd.com/read/28181188/atorvastatin-promotes-cytotoxicity-and-reduces-migration-and-proliferation-of-human-a172-glioma-cells
#9
Karen A Oliveira, Tharine Dal-Cim, Flávia G Lopes, Fabiana K Ludka, Cláudia B Nedel, Carla I Tasca
Malignant gliomas have resistance mechanisms to chemotherapy that enable tumor invasiveness and aggressiveness. Alternative therapies in cancer treatment, as statins, have been suggested to decrease proliferation, inhibit cell migration, and induce cell death. The aim of this study was to evaluate the effect of atorvastatin (ATOR) on cell viability, migration, proliferation, apoptosis, and autophagy in A172 human glioma cells. Temozolomide (TMZ), a chemotherapic used to glioma treatment, was tested as a comparison to cytotoxic effects on gliomas...
February 8, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28177908/therapeutic-effects-of-atorvastatin-and-ezetimibe-compared-with-double-dose-atorvastatin-in-very-elderly-patients-with-acute-coronary-syndrome
#10
Zhi Liu, Hengjian Hao, Chunlin Yin, Yanyan Chu, Jing Li, Dong Xu
Objective Compared the effect of atorvastatin 10 mg combined ezetimibe 10 mg therapy with atorvastatin 20 mg on the long-term outcomes in very elderly patients with acute coronary syndrome.Methods A total of 230 octogenarian patients with acute coronary syndrome underwent coronary angiography were randomized to combined therapy group (atorvastatin 10 mg/d and ezetimibe 10 mg/d, n=114) or double-dose atorvastatin group (atorvastatin 20mg/d, n=116). The primary end point was one-year incidence of major adverse cardiovascular events (including cardiac death, spontaneous myocardial infarction, unplanned revascularization)...
February 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28167509/results-from-a-phase-i-ii-open-label-dose-finding-study-of-pralatrexate-and-oral-bexarotene-in-patients-with-relapsed-refractory-cutaneous-t-cell-lymphoma
#11
Madeleine Duvic, Youn H Kim, Pier Luigi Zinzani, Steven Horwitz
PURPOSE: Pralatrexate is a folic acid analog metabolic inhibitor similar to methotrexate,that has shown tolerability and efficacy with an overall response rate of 45% in a phase 1 dose de-escalation study of patients with relapsed/refractory cutaneous T-cell lymphoma CTCL. EXPERIMENTAL DESIGN: The object of this phase I/II open-label, multi-center clinical trial was to determine the maximum tolerated dose (MTD) and recommended dose of pralatrexate plus oral bexarotene in 34 patients with relapsed/refractory CTCL who had failed prior systemic therapies...
February 6, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28167473/therapeutic-effect-of-atorvastatin-on-kidney-functions-and-urinary-excretion-of-glimepiride-in-healthy-adult-human-male-subjects
#12
Tayyaba Sana, Bilal Aslam, Nosheen Aslam, Muhammad Mudassar Ashraf, Asma Ashraf, Tahir Aqeel Malik, Sammia Gul Niazi, Imtiaz Mahmood Tahir, Muhammad RiazurRehman, Hamad Ahmed
Glimepiride and atorvastatin in combination are commonly employed for treating the hyperglycemia and dyslipidemia, respectively, in patients of type 2 diabetes. The present study was designed to find out the influence of atorvastatin on urinary excretion and renal clearance of Glimepiride in healthy adult male volunteers. In each experimental subject, Glimepiride 2mg was given orally after an overnight fasting. Samples of blood and urine were taken at different specific time intervals. After a washout period of ten days, Glimepiride 2mg was co-administered with atorvastatin 20mg orally...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28165667/use-of-moderate-intensity-statins-for-low-density-lipoprotein-cholesterol-level-above-190-mg-dl-at-baseline-in-koreans
#13
Hun-Sung Kim, Hyeseon Lee, Sue Hyun Lee, Yoo Jin Jeong, Tong Min Kim, So Jung Yang, Sun Jung Baik, Hyunah Kim, Seung-Hwan Lee, Jae Hyoung Cho, In-Young Choi, Kun-Ho Yoon, Ju Han Kim
The ACC/AHA 2013 guideline recommends high-intensity statin therapy for a decrease in low-density lipoprotein cholesterol (LDL-C) level by >50% among patients with baseline values of ≥190 mg/dL (approximately 4.872 mmol/L); however, this value should be modified before applying it to Korean populations. We investigated the statin-specific LDL-C-lowering effects in Korean patients with baseline LDL-C value ≥ 4.872 mmol/L. Data of patients prescribed a statin for the first time from January 2009 to December 2013 were assessed...
February 6, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28165015/enhancing-the-biocatalytic-manufacture-of-the-key-intermediate-of-atorvastatin-by-focused-directed-evolution-of-halohydrin-dehalogenase
#14
Yu Luo, Yangzi Chen, Hongmin Ma, ZhenHua Tian, Yeqi Zhang, Jian Zhang
Halohydrin dehalogenases (HHDHs) are biocatalytically interesting enzymes due to their ability to form C-C, C-N, C-O, and C-S bonds. One of most important application of HHDH was the protein engineering of HheC (halohydrin dehalogenase from Agrobacterium radiobacter AD1) for the industrial manufacturing of ethyl (R)-4-cyano-3-hydroxybutanoate (HN), a key chiral synthon of a cholesterol-lowering drug of atorvastatin. During our development of an alternative, more efficient and economic route for chemo-enzymatic preparation of the intermediate of atorvastatin, we found that the HheC2360 previously reported for HN manufacture, had insufficient activity for the cyanolysis production of tert-butyl (3 R,5 S)-6-cyano-3,5-dihydroxyhexanoate (A7)...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28162160/-effects-of-apoe-gene-polymorphism-on-the-efficacy-of-atorvastatin-in-the-treatment-of-hyperlipidemia
#15
Y Zhang, D D Wei, R R Yuan, Q X Ge, F Chen, S X Yang, B P Chen, J Shi
Objective: To study the role of ApoE gene polymorphism on efficacy of atorvastatin in lowering the lipid and its clinical significance. Methods: A total of 962 patients with hypercholesterolemia were selected between January 1 st and December 31 st 2014. The ApoE genepolymorphism in patients with hyperlipidemia was performed by using polymerase chain reaction with restriction fragment length polymorphism (PCR-RFLP) method in translational medicine center of Huaihe Hospital. Patients with ApoE genotype E3/3 and E3/4 were selected and treated with atorvastatin 10 mg/d for 4 weeks...
January 24, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28159489/atorvastatin-from-target-screening-attenuates-endothelial-cell-tube-formation-and-migration-by-regulating-urokinase-receptor-related-signaling-pathway-and-f-g-actin
#16
Li Wei, Jin-Shuen Chen, Hsin-Ting Lin, Chung-Ze Wu, Cai-Mei Zheng, Yu-Ching Chang, Li-Chien Chang, Yuh-Feng Lin
BACKGROUND: Angiogenesis and cytoskeletal transformation are common denominators of many pathological developments. The relationship between angiogenesis, urokinase plasminogen activator receptor (uPAR) signaling pathway, and cytoskeletal transformation is still unknown. In this study, a pGL3-uPAR promoter reporter system combined with Bio-Plex mRNA analysis was established for discovering uPAR modulators to analyze this interconnection. METHODS: After screening a set of clinically used drugs, atorvastatin (Ator) was found to significantly affect uPAR expression and its ideal dose, 1 μM, was determined for cell study...
January 31, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28155189/diabetes-secondary-to-treatment-with-statins
#17
REVIEW
Markku Laakso, Johanna Kuusisto
PURPOSE OF REVIEW: This review summarizes the recent population-based studies, clinical trials, clinical metabolic studies, and genetic studies reporting the effects of statin therapy on the risk of diabetes. Recent studies aiming to explain the mechanisms how statin treatment affects insulin sensitivity and insulin secretion are also reviewed. RECENT FINDINGS: Statin therapy increases the risk of diabetes by 9%-12% in the two meta-analyses of statin trials and by 18%-99% in five population-based studies...
February 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28142075/platelet-tissue-factor-activity-and-membrane-cholesterol-are-increased-in-hypercholesterolemia-and-normalized-by-rosuvastatin-but-not-by-atorvastatin
#18
Olga Panes, César González, Patricia Hidalgo, Juan P Valderas, Mónica Acevedo, Susana Contreras, Ximena Sánchez, Jaime Pereira, Attilio Rigotti, Diego Mezzano
BACKGROUND AND AIMS: High plasma LDL-cholesterol (LDL-C) and platelet responses have major pathogenic roles in atherothrombosis. Thus, statins and anti-platelet drugs constitute mainstays in cardiovascular prevention/treatment. However, the role of platelet tissue factor-dependent procoagulant activity (TF-PCA) has remained unexplored in hypercholesterolemia. We aimed to study platelet TF-PCA and its relationship with membrane cholesterol in vitro and in 45 hypercholesterolemic patients (HC-patients) (LDL-C >3...
December 16, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/28140741/lipid-lowering-property-of-clausena-anisum-olens-in-hypercholesterolemic-rats
#19
Anbel M Bautista, Mario A Tan, Jovencio M Apostol
CONTEXT: Clausena anisum-olens (Blanco) Merr. (Rutaceae) is a medicinal shrub which has been reported to have various pharmacological uses. No study regarding the effects of C. anisum-olens on cholesterol-lowering has been reported. OBJECTIVE: The effects of the ethanol extract of C. anisum-olens leaves on the cholesterol level of hypercholesterolemic rats were evaluated. MATERIALS AND METHODS: Acute oral toxicity of the extract (175, 550 and 2000 mg/kg) was determined using female Sprague-Dawley rats, as described in OECD 425 Main test guidelines...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28131079/-1-h-nmr-based-metabolomics-reveals-sub-lethal-toxicity-of-a-mixture-of-diabetic-and-lipid-regulating-pharmaceuticals-on-amphibian-larvae
#20
Steven D Melvin, Leesa J Habener, Frederic D L Leusch, Anthony R Carroll
Pharmaceuticals are widely used for the treatment of various physical and psychological ailments. Due to incomplete removal during sewage treatment many pharmaceuticals are frequently detected in aquatic waterways at trace concentrations. The diversity of pharmaceutical contaminants and potential for complex mixtures to occur makes it very difficult to predict the toxicity of these compounds on wildlife, and robust methods are therefore needed to explore sub-lethal effects. Metabolic syndrome is one of the most widespread health concerns currently facing the human population, and various drugs, including anti-diabetic medications and lipid- and cholesterol-lowering fibrates and statins, are widely prescribed as treatment...
March 2017: Aquatic Toxicology
keyword
keyword
6831
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"