keyword
MENU ▼
Read by QxMD icon Read
search

Atorvastatin

keyword
https://www.readbyqxmd.com/read/29453473/prehospital-events-in-st-elevation-myocardial-infarction-undergoing-primary-angioplasty
#1
Sachin Dhungel, Rabi Malla, Chandramani Adhikari, Arun Maskey, Rajeeb Rajbhandari, Ranjit Sharma, Deewakar Sharma, Man Bhadhur Kc, Ajay Adhikari, Binaya Rauniyar, Dipak Limbu, Milan Gautam
INTRODUCTION: Pre-hospital delay includes time from onset of symptoms of myocardial infarction till arrival to emergency room of the hospital. This defines time from symptom onset to first medical contact and first medical contact to emergency room. This study aims to study the prehospital events and determining factors in patients undergoing primary angioplasty. METHODS: This was a cross sectional study in Shahid Gangalal National Heart Centre for three months...
October 2017: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/29452493/in-vitro-and-in-vivo-evaluation-of-cyclodextrin-based-nanosponges-for-enhancing-oral-bioavailability-of-atorvastatin-calcium
#2
Mohamed F Zidan, Hany M Ibrahim, Mohsen I Afouna, Elsherbeny A Ibrahim
The aim of this study was to explore the feasibility of complexing the poorly water-soluble drug atorvastatin calcium (AC) with β-cyclodextrin (β-CD) based nanosponges (NS), which offer advantages of improving dissolution rate and eventually oral bioavailability. Blank NS were fabricated at first by reacting β-CD with the cross-linker carbonyldiimidazole at different molar ratios (1:2, 1:4 and 1:8), then NS of highest solubilization extent for AC were complexed with AC. AC loaded NS (AC-NS) were characterized for various physicochemical properties...
February 16, 2018: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29447778/the-effect-of-high-dose-atorvastatin-on-neural-activity-and-cognitive-function
#3
Beth A Taylor, Alecia D Dager, Gregory A Panza, Amanda L Zaleski, Shashwath Meda, Gregory Book, Michael C Stevens, Sarah Tartar, C Michael White, Donna M Polk, Godfrey D Pearlson, Paul D Thompson
BACKGROUND: Functional magnetic resonance imaging (fMRI) has not been used to assess the effects of statins on the brain. We assessed the effect of statins on cognition using standard neuropsychological assessments and brain neural activation with fMRI on two tasks. METHODS: Healthy statin-naïve men and women (48±15 years) were randomized to 80 mg/day atorvastatin (n=66; 27 men) or placebo (n=84; 48 men) for 6 months. Participants completed cognitive testing while on study drug and 2 months after treatment cessation using alternative test and task versions...
March 2018: American Heart Journal
https://www.readbyqxmd.com/read/29447777/cognition-and-brain-changes-associated-with-high-dose-atorvastatin-a-bold-proposition
#4
EDITORIAL
Jeffrey N Browndyke, Mitchell T Heflin
No abstract text is available yet for this article.
March 2018: American Heart Journal
https://www.readbyqxmd.com/read/29445633/the-effect-of-intensive-statin-therapy-on-symptomatic-intracranial-arterial-stenosis
#5
Peiyang Zhou, Zhihua Cao, Pu Wang, Guangzhi Liu, Xuan Yao, Puqing Wang, Guang Li, Guibin Zhang, Ping Gao
Background: The aim of this study was to observe the effect of intensive statin therapy on symptomatic intracranial arterial stenosis. Methods: overall, 120 patients with symptomatic intracranial arterial stenosis were admitted to the Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, China from January 2010 to May 2013. They were randomly divided into three groups and were given different doses of atorvastatin orally for 1 year or more, and followed up for 12 months...
February 2018: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29442055/incidence-of-statin-drug-interactions-in-croatian-community-pharmacy
#6
I Samardzic, I Benkovic, V Bacic Vrca
Statins are among the most frequently issued drugs that patients usually need to take for a lifetime. They are often an integral part of a polytherapeutic approach in preventing and treating cardiovascular diseases. As such, they might often interact with drugs prescribed for treating acute and chronic conditions. A pharmacist is the final professional control before a drug reaches the patient and his role in preventing drug-drug interactions is crucial. The objective of this research was to analyse the incidence and relevance of potential drug interactions with statins in community pharmacy...
March 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29442027/the-effect-of-slco1b1-polymorphism-on-the-pharmacokinetics-of-atorvastatin-and-2-hydroxyatorvastatin-in-healthy-chinese-people
#7
Yaqin Wang, Yingying Tian, Peiyu Lv, Lulu Chen, Wei Luo, Xian Jing, Hui Li, Zhirong Tan, Yicheng Wang, Honghao Zhou, Dong-Sheng Ouyang
The pharmacokinetics of statins show substantial inter-subject variability. Increasing systemic exposure of statins may lead to adverse drug reactions such as myopathy. The variation in statin pharmacokinetics is partly explained by genetic factors. OATP1B1, coded by SLCO1B1 transports a large number of therapeutic drugs, such as atorvastatin. Here we investigated the effect of SLCO1B1 polymorphism on the pharmacokinetics of atorvastatin and its metabolites. Two pharmacokinetic studies were conducted in Chinese Han volunteers and 132 volunteers were enrolled in our study as 72 in trial 1 and 60 in trial 2...
June 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29441875/influence-of-slco1b1-polymorphisms-on-atorvastatin-efficacy-and-safety-in-macedonian-subjects
#8
K Mladenovska, A Daka Grapci, M Vavlukis, A Kapedanovska, A Eftimov, N Matevska Geshkovska, D Nebija, A J Dimovski
Atorvastatin, as 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, is a widely prescribed medication for the treatment of dyslipidemia. However, despite its clinical efficacy in reducing major cardiovascular events, a wide inter-individual variability in its response exists. Several studies in this area point to the effect of polymorphisms in the solute carrier organic anion transporter 1B1 (SLCO1B1) gene encoding the multiple organic anion-transporting polypeptide 1B1 (OATP1B1) involved in hepatic uptake of atorvastatin...
May 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29439129/simultaneous-assessment-in-vitro-of-transporter-and-metabolic-processes-in-hepatic-drug-clearance-use-of-a-media-loss-approach
#9
James Harrison, Tom De Bruyn, Adam S Darwich, J Brian Houston
Hepatocyte drug depletion-time assays are well established for the determination of metabolic clearance in vitro. The present study focuses on the refinement and evaluation of a "media loss" assay, an adaptation of the conventional depletion assay involving centrifugation of hepatocytes prior to sampling, allowing estimation of uptake in addition to metabolism. Using experimental procedures consistent with a high throughput, a selection of 12 compounds with a range of uptake and metabolism characteristics (atorvastatin, cerivastatin, clarithromycin, erythromycin, indinavir, pitavastatin, repaglinide, rosuvastatin, saquinavir and valsartan, together with two control compounds - midazolam and tolbutamide) were investigated in the presence and absence of the cytochrome P450 inhibitor 1-aminobenzotriazole and organic anion transporter protein inhibitor rifamycin SV...
February 8, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29432061/atorvastatin-treatment-modulates-the-gut-microbiota-of-the-hypercholesterolemic-patients
#10
Tariq Jamal Khan, Youssri M Ahmed, Mazin A Zamzami, Aisha M Siddiqui, Imran Khan, Othman A S Baothman, Mohamed G Mehanna, Abudukadeer Kuerban, Mohammed Kaleemuddin, Muhammad Yasir
Hypercholesterolemia is one of the most important risk factors for development of cardiovascular diseases. The composition of gut microbiota (total microbes residing in the gut) impacts on cholesterol and lipid metabolism. On the contrary, alterations in gut microbiota in response to hypercholesterolemia or drug treatment with atorvastatin (a cholesterol-lowering agent) are rarely investigated. We performed 16S rDNA amplicon sequencing to evaluate the gut bacterial community of 15 untreated hypercholesterolemic patients (HP) and 27 atorvastatin-treated hypercholesterolemic patients (At-HP) and compared with 19 healthy subjects (HS)...
February 2018: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29427912/adjunctive-therapy-with-statins-in-schizophrenia-patients-a-meta-analysis-and-implications
#11
Hong Shen, Rui Li, Rong Yan, Xia Zhou, Xia Feng, Mengjie Zhao, Hong Xiao
There are some conflicting results regarding the benefit of adjunctive therapy with statins for severity of negative symptoms in schizophrenia. This study aimed to verify whether statins use for adjunctive therapy was indeed beneficial to improve psychiatric symptoms in schizophrenia. The data were from CENTRAL, PubMed, Embase and MEDLINE. The Boolean search term used for the electronic database search was (statin OR simvastatin OR atorvastatin OR fluvastatin OR lovastatin OR mevastatin OR pitavastatin OR pravastatin OR rosuvastatin OR cerivastatin) and (schizophrenia OR schizoaffective disorder OR psychosis)...
February 5, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29427701/statins-differentially-modulate-micrornas-expression-in-peripheral-cells-of-hyperlipidemic-subjects-a-pilot-study
#12
Tomás Zambrano, Rosario D C Hirata, Mario H Hirata, Álvaro Cerda, Luis A Salazar
AIM: Although statins are considered a cornerstone for the treatment of high cholesterol levels due to their powerful cholesterol-lowering effects, response to drug administration is still one of the main pitfalls of statin treatment. So far, the reasons underlying this undesired outcome are still poorly understood, but recently, various studies have suggested that miRNAs may be involved. Therefore, we aimed at evaluating the effect of short-term low-dose treatment with 2 statins on miRNAs expression in patients with hypercholesterolemia...
February 7, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29427042/amyotrophic-lateral-sclerosis-associated-with-statin-use-a-disproportionality-analysis-of-the-fda-s-adverse-event-reporting-system
#13
Beatrice A Golomb, Abril Verden, Alexis K Messner, Hayley J Koslik, Keith B Hoffman
INTRODUCTION: Apparent elevations in reporting of amyotrophic lateral sclerosis (ALS)-like conditions associated with statin use have been previously described from data obtained via US and European databases. OBJECTIVE: The aim of this study was to examine US FDA Adverse Event Reporting System (FAERS) data to compare reporting odds ratios (RORs) of ALS and ALS-like conditions between statins and other drugs, for each statin agent. METHODS: We assessed for disproportional rates of reported ALS and ALS-related conditions for each statin agent separately by using the ROR formula...
February 9, 2018: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29425980/dose-dependent-effects-of-statins-for-patients-with-aneurysmal-subarachnoid-hemorrhage-meta-regression-analysis
#14
REVIEW
Minh-Son To, Shivesh Prakash, Santosh I Poonnoose, Shailesh Bihari
OBJECTIVE: The study utilizes meta-regression analysis to quantify the dose-dependent effects of statin pharmacotherapy on vasospasm, delayed ischemic neurologic deficits (DINDs) and mortality in aneurysmal subarachnoid hemorrhage (aSAH). METHODS: Prospective, retrospective observational studies and randomized controlled trials (RCTs) were retrieved by a systematic database search. Summary estimates were expressed as absolute risk (AR) for a given statin dose or control (placebo)...
February 6, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29424763/atorvastatin-induced-dermatomyositis-resolution-with-change-in-statin
#15
Jeffrey Spiro, Melissa Butts
No abstract text is available yet for this article.
February 7, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29419569/statin-effects-on-myocardial-fibrosis-markers-in-people-living-with-hiv
#16
Christopher deFilippi, Robert Christenson, Jessica Joyce, Elli A Park, Ashley Wu, Kathleen V Fitch, Sara E Looby, Michael T Lu, Udo Hoffmann, Steven K Grinspoon, Janet Lo
BACKGROUND: In observational studies, HIV patients have higher levels of soluble ST2 (sST2), galectin-3, growth differentiation factor-15 (GDF-15) than non-HIV controls. As statins exert pleiotropic immunomodulatory effects that may affect markers of myocardial fibrosis, the objective of the current study is to determine if biomarkers of myocardial fibrosis reflecting subclinical pathology may be modified by statin therapy in patients with HIV. SETTING: and Methods: 40 HIV+ men and women participated in a single center 12-month randomized, double-blind placebo controlled trial of atorvastatin 40mg qd vs...
February 6, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29417448/atorvastatin-attenuates-cognitive-deficits-and-neuroinflammation-induced-by-a%C3%AE-1-42-involving-modulation-of-tlr4-traf6-nf-%C3%AE%C2%BAb-pathway
#17
Shan Wang, Xiaowei Zhang, Liuyu Zhai, Xiaona Sheng, Weina Zheng, Hongshan Chu, Guohua Zhang
Inflammatory damage aggravates the progression of Alzheimer's disease (AD) and the mechanism of inflammatory damage may provide a new therapeutic window for the treatment of AD. Toll-like receptor 4 (TLR4)-mediated signaling can regulate the inflammatory process. However, changes in TLR4 signaling pathway induced by beta-amyloid (Aβ) have not been well characterized in brain, especially in the hippocampus. In the present study, we explored the changes of TLR4 signaling pathway induced by Aβ in the hippocampus and the role of atorvastatin in modulating this signal pathway and neurotoxicity induced by Aβ...
February 7, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29413104/apoptosis-in-pancreatic-%C3%AE-cells-is-induced-by-arsenic-and-atorvastatin-in-wistar-rats-with-diabetes-mellitus-type-2
#18
Tania Guadalupe Delgado-León, José Manuel Sálas-Pacheco, Fernando Vazquez-Alaniz, Ángel Antonio Vértiz-Hernández, Olga Dania López-Guzmán, Eduardo Lozano-Guzmán, Aurora Martínez-Romero, Norma Úrtiz-Estrada, Maribel Cervantes-Flores
INTRODUCTION: Diabetes Mellitus type 2 (T2D) is a multifactorial disease. However, it is known that there is an important effect in pancreatic β-cells caused by apoptosis of pro-apoptotic proteins, possibly related to arsenic exposure and atorvastatin treatment. OBJECTIVE: The goal of this study was to evaluate the effects of atorvastatin treatment on apoptosis of pancreatic β-cells in Wistar rats with induced diabetes type 2 exposed to arsenic. MATERIAL & METHODS: T2D in Wistar rats was induced by administration of Streptozotocin...
March 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29412674/combination-of-phospholipid-complex-and-submicron-emulsion-techniques-for-improving-oral-bioavailability-and-therapeutic-efficacy-of-water-insoluble-drug
#19
Linghao Qin, Yawei Niu, Yuemin Wang, Xiaomei Chen
Water-insoluble drugs can not be absorbed effectively through gastrointestinal tract due to insufficient solubility and often face the problems of low bioavailability and poor therapeutic efficacy. To overcome these biopharmaceutical challenges, lipid-based formulations were suggested and have been researched in recent years. In this study, we used atorvastatin as a model drug to prepare a phospholipid complex pro-drug system to upgrade its lipophilicity and further developed a drug loaded submicron emulsion to improve its in vivo bioavailability...
February 7, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29405807/interaction-of-deoxyschizandrin-and-schizandrin-b-with-liver-uptake-transporters-oatp1b1-and-oatp1b3
#20
Yanli Lu, Qingqing Hu, Lin Chen, Hong Zhang, Shibo Huang, Yuqing Xiong, Chunhua Xia
1. Deoxyschizandrin and schizandrin B have diverse pharmacological effects, including hepatoprotective activity. We aim to study their hepatic uptake and their effects on the hepatic uptake of other clinical drugs mediated by OATP1B1 and OATP1B3. 2. Deoxyschizandrin exhibited a high affinity for OATP1B1 with Km of 17.61 ± 0.43 μM but a low affinity for OATP1B3. Similarly, schizandrin B also showed a strong affinity for OATP1B1 with Km of 18.45 ± 1.23 μM but a weak affinity for OATP1B3. 3. Atorvastatin and rifampicin could inhibit the uptake of deoxyschizandrin and schizandrin B mediated by OATP1B1...
February 6, 2018: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
keyword
keyword
6831
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"