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https://www.readbyqxmd.com/read/29319327/warfarin-dose-adjustment-after-biliopancreatic-diversion-duodenal-switch-bariatric-surgery
#1
Catherine Bolduc, Joëlle Flamand-Villeneuve, Isabelle Giroux, Stéfane Lebel, Serge Simard, Frédéric Picard
BACKGROUND: The absorption of drugs and fat-soluble vitamins is impaired after bariatric surgery on which intestinal length and function are altered. In this context, the anticoagulant effect of warfarin is difficult to predict in the postoperative period. OBJECTIVE: This study aimed at describing the average weekly warfarin dose required to maintain a therapeutic international normalized ratio (INR) before and up to 1 year after sleeve gastrectomy with biliopancreatic diversion and duodenal switch (BPD/DS)...
January 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29311499/transcatheter-aortic-valve-implantation-tavi-for-native-aortic-valve-regurgitation%C3%A3-a-systematic-review
#2
Altayyeb Yousef, Zachary MacDonald, Trevor Simard, Juan J Russo, Joshua Feder, Michael V Froeschl, Alexander Dick, Christopher Glover, Ian G Burwash, Azeem Latib, Josep Rodés-Cabau, Marino Labinaz, Benjamin Hibbert
BACKGROUND: Transcatheter aortic valve implantation (TAVI) has become the standard of care for management of high-risk patients with aortic stenosis. Limited data is available regarding the performance of TAVI in patients with native aortic valve regurgitation (NAVR).Methods and Results:We performed a systematic review from 2002 to 2016. The primary outcome was device success as per VARC-2 criteria. Secondary endpoints included procedural complications, and 30-day and 1-year mortality rates...
December 28, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29311329/dysregulation-of-cotranscriptional-alternative-splicing-underlies-charge-syndrome
#3
Catherine Bélanger, Félix-Antoine Bérubé-Simard, Elizabeth Leduc, Guillaume Bernas, Philippe M Campeau, Seema R Lalani, Donna M Martin, Stephanie Bielas, Amanda Moccia, Anshika Srivastava, David W Silversides, Nicolas Pilon
CHARGE syndrome-which stands for coloboma of the eye, heart defects, atresia of choanae, retardation of growth/development, genital abnormalities, and ear anomalies-is a severe developmental disorder with wide phenotypic variability, caused mainly by mutations in CHD7 (chromodomain helicase DNA-binding protein 7), known to encode a chromatin remodeler. The genetic lesions responsible for CHD7 mutation-negative cases are unknown, at least in part because the pathogenic mechanisms underlying CHARGE syndrome remain poorly defined...
January 8, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29301086/role-of-hydrogen-in-high-yield-growth-of-boron-nitride-nanotubes-at-atmospheric-pressure-by-induction-thermal-plasma
#4
Keun Su Kim, Martin Couillard, Homin Shin, Mark Plunkett, Dean Ruth, Christopher T Kingston, Benoit Simard
Recently, we demonstrated scalable manufacturing of boron nitride nanotubes (BNNTs) directly from hBN powder by using induction thermal plasma, with a high-yield rate approaching to 20 g/h. The main finding was that the presence of hydrogen is crucial for the high-yield growth of BNNTs. Here we investigate the detailed role of hydrogen by numerical modeling and in-situ optical emission spectroscopy (OES), and reveal that both the thermo-fluidic fields and chemical pathways are significantly altered by hydrogen in favor of rapid growth of BNNTs...
January 4, 2018: ACS Nano
https://www.readbyqxmd.com/read/29298183/an-integrated-career-coaching-and-time-banking-system-promoting-flexibility-wellness-and-success-a-pilot-program-at-stanford-university-school-of-medicine
#5
Magali Fassiotto, Caroline Simard, Christy Sandborg, Hannah Valantine, Jennifer Raymond
Faculty in academic medicine experience multiple demands on their time at work and at home, which can become a source of stress and dissatisfaction, compromising success. A taskforce convened to diagnose the state of work-life flexibility at Stanford University School of Medicine uncovered two major sources of conflict for faculty: work-life conflict, caused by juggling demands of career and home, and work-work conflict, caused by competing priorities of the tripartite research, teaching, and clinical mission of an academic medical center combined with service and administrative tasks...
January 2, 2018: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29287214/favorable-adverse-effect-profile-of-brivaracetam-vs-levetiracetam-in-a-preclinical-model
#6
Nathalie T Sanon, Jonathan Gagné, Daniele C Wolf, Soumia Aboulamer, Ciprian M Bosoi, Alexe Simard, Estelle Messiet, Sébastien Desgent, Lionel Carmant
Levetiracetam (LEV), and its newer selective analog brivaracetam (BRV), are two seizure medications that share an innovative mechanism of action targeting the Synaptic Vesicle Protein 2A (SV2A), altering neurotransmitter release and decreasing seizure frequency. Behavioral changes are the most significant adverse effects reported by patients taking LEV. We hypothesize that BRV, the more potent SV2A analog, could exert less behavioral side effects, as it requires lower doses than LEV. Using Kainic Acid (KA)-treated and control rats, we measured adverse behavioral effect profiles of LEV, BRV, or Saline, on social and nonsocial behaviors...
December 26, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29280715/comparison-of-two-tools-to-assess-sensory-features-in-children-with-autism-spectrum-disorder
#7
Catherine Dugas, Marie-Noëlle Simard, Eric Fombonne, Mélanie Couture
OBJECTIVE: This article documents the convergent validity of the Sensory Profile (SP) and the Sensory Processing Measure (SPM)-Home Form for children with autism spectrum disorder (ASD). METHO: . Parents of 34 children with ASD between ages 5 and 8 yr filled out both measures. Through correlations, χ² tests, and levels of agreement between classifications, the results for the SP and the SPM-Home Form were compared. RESULTS: The raw scores were correlated for some sensory domains (hearing, vision, touch, and proprioception) and for social functioning...
January 2018: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/29277079/relationships-between-dbp-concentrations-and-differential-uv-absorbance-in-full-scale-conditions
#8
Nicolas Beauchamp, Olivier Laflamme, Sabrina Simard, Caetano Dorea, Geneviève Pelletier, Christian Bouchard, Manuel Rodriguez
Differential UV spectroscopy, defined as the difference in UV absorbance spectra before and after chlorination, has shown great potential to predict disinfection by-product (DBP) concentrations at laboratory scale. However, so far, no results have been reported on the full scale application of differential UV spectroscopy in drinking water treatment facilities. The objectives of this study are to determine if relationships can be developed between differential UV absorbance and DBP concentrations, for both regulated and unregulated DBPs, in a full-scale facility and to determine if these relationships vary throughout the year with variations in raw water quality and treatment conditions...
December 18, 2017: Water Research
https://www.readbyqxmd.com/read/29276147/evaluation-of-cobalt-and-chromium-levels-following-implantation-of-cobalt-chromium-coronary-stents-a-pilot-study
#9
Pietro Di Santo, Pouya Motazedian, Richard G Jung, Trevor Simard, F Daniel Ramirez, Aun-Yeong Chong, Christopher Glover, Benjamin Hibbert, Girish Dwivedi
BACKGROUND: Large increases in myocardial trace elements may adversely affect metabolism and become detrimental to cardiac function. Percutaneous coronary intervention (PCI) allows for the revascularisation of obstructive coronary artery disease using drug-eluting stents. These stents are comprised of a metallic stent backbone covered in an engineered polymer which delivers a drug over a prescribed period to the vessel wall. Given the potential implications of trace metal accumulation within the myocardium, our goal is to determine if metallic coronary stents are able to cause detectable elevations in serum cobalt and/or chromium levels...
December 14, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29273683/functional-implications-of-corticosteroid-binding-globulin-n-glycosylation
#10
Marc Simard, Caroline Underhill, Geoffrey L Hammond
Corticosteroid-binding globulin (CBG) is a plasma carrier of glucocorticoids. Human and rat CBGs have six N-glycosylation sites. Glycosylation of human CBG influences its steroid-binding activity and there are N-glycosylation sites in the reactive center loops (RCLs) of human and rat CBGs. Proteolysis of the RCL of human CBG causes a structural change that disrupts steroid binding. We now show that mutations of conserved N-glycosylation sites at N238 in human CBG and N230 in rat CBG disrupt steroid binding...
December 22, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29247199/lipidomics-reveals-cerebrospinal-fluid-signatures-of-als
#11
H Blasco, C Veyrat-Durebex, C Bocca, F Patin, P Vourc'h, J Kouassi Nzoughet, G Lenaers, C R Andres, G Simard, P Corcia, P Reynier
Amyotrophic lateral sclerosis (ALS), the commonest adult-onset motor neuron disorder, is characterized by a survival span of only 2-5 years after onset. Relevant biomarkers or specific metabolic signatures would provide powerful tools for the management of ALS. The main objective of this study was to investigate the cerebrospinal fluid (CSF) lipidomic signature of ALS patients by mass spectrometry to evaluate the diagnostic and predictive values of the profile. We showed that ALS patients (n = 40) displayed a highly significant specific CSF lipidomic signature compared to controls (n = 45)...
December 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29225557/toward-the-development-of-a-flexible-mesoscale-mri-compatible-neurosurgical-continuum-robot
#12
Yeongjin Kim, Shing Shin Cheng, Mahamadou Diakite, Rao P Gullapalli, J Marc Simard, Jaydev P Desai
Brain tumor, be it primary or metastatic, is usually life threatening for a person of any age. Primary surgical resection which is one of the most effective ways of treating brain tumors can have tremendously increased success rate if the appropriate imaging modality is used for complete tumor resection. Magnetic resonance imaging (MRI) is the imaging modality of choice for brain tumor imaging because of its excellent soft-tissue contrast. MRI combined with continuum soft robotics has immense potential to be the next major technological breakthrough in the field of brain cancer diagnosis and therapy...
December 2017: IEEE Transactions on Robotics: a Publication of the IEEE Robotics and Automation Society
https://www.readbyqxmd.com/read/29217129/long-alimentary-limb-duodenal-switch-lads-a-short-term-prospective-randomized-trial
#13
Anabelle Cloutier, Stéfane Lebel, Frédéric Hould, François Julien, Simon Marceau, Léonie Bouvet, Serge Simard, Laurent Biertho
BACKGROUND: Biliopancreatic diversion with duodenal switch (BPD-DS) is one of the most effective bariatric surgeries, in terms of weight loss and remission of co-morbidities. It is however associated with a significant risk of protein and nutritional deficiency, as well as gastrointestinal side effects. OBJECTIVES: To assess the effect of increasing the strict alimentary limb on weight loss, nutritional deficiency and quality of life, compared with standard BPD-DS...
November 8, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29212567/the-quebec-emergency-department-guide-a-cross-sectional-study-to-evaluate-its-use-perceived-usefulness-and-implementation-in-rural-emergency-departments
#14
Richard Fleet, Sandrine Hegg-Deloye, Julie Maltais-Giguère, France Légaré, Mathieu Ouimet, Julien Poitras, Alain Tanguay, Patrick Archambault, Jean-Frédéric Levesque, Geneviève Simard-Racine, Gilles Dupuis
OBJECTIVES: The Quebec Emergency Department Management Guide (QEDMG) is a unique document with 78 recommendations designed to improve the organization of emergency departments (EDs) in the province of Quebec. However, no study has examined how this guide is perceived or used by rural health care management. METHODS: We invited all directors of professional services (DPS), directors of nursing services (DNS), head nurses (HN), and emergency department directors (EDD) working in Quebec's rural hospitals to complete an online survey (144 questions)...
December 7, 2017: CJEM
https://www.readbyqxmd.com/read/29206779/concentration-range-of-serum-sex-steroids-in-normal-postmenopausal-women-and-those-with-diagnosis-of-vulvovaginal-atrophy
#15
Yuyong Ke, Alain Bélanger, Jean-Nicolas Simard, Renaud Gonthier, Céline Martel, Mario Vaillancourt, Fernand Labrie
OBJECTIVE: The aim of the study was to determine the range of serum sex-related steroids in normal postmenopausal women and in women of the same age with a diagnosis of vulvovaginal atrophy (VVA). METHODS: Validated mass spectrometry-based assays coupled to gas or liquid chromatography were used over a 10-year period for steroid measurements. Serum samples were obtained in up to 1,512 women aged 55 to 65 years. RESULTS: Serum estrone sulfate (E1S) and androsterone glucuronide (ADT-G), the main metabolites of estrogens and androgens, respectively, were 16...
December 4, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29199842/a-preliminary-survey-of-pediatricians-experiences-with-and-preferences-for-communication-with-mental-health-specialists
#16
Duncan G Campbell, Andrew Downs, William J Meyer, Megan M McKittrick, Nicole M Simard, Patricia O'Brien
INTRODUCTION: Pediatricians are more likely than mental health (MH) specialists to manage children's MH concerns, and multiple factors complicate their abilities to do so adequately. Integrated care initiatives mitigate systems-related shortcomings that hamstring MH management in primary care. These initiatives, which improve outcomes for adults, are not widespread for youth. Integrated health care for children with MH concerns requires regular collaborative communication among pediatricians and MH specialists...
December 4, 2017: Families, Systems & Health: the Journal of Collaborative Family Healthcare
https://www.readbyqxmd.com/read/29175359/trial-duration-and-risk-reduction-in-combination-therapy-trials-for-pulmonary-arterial-hypertension-a-systematic-review
#17
Annie-Christine Lajoie, Charles-Antoine Guay, Jean-Christophe Lega, Gabriel Lauzière, Serge Simard, Caroline Lambert, Yves Lacasse, Sebastien Bonnet, Steve Provencher
BACKGROUND: Relative risk (RR) and number needed to treat (NNT) are frequently time-dependant measures. We performed a systematic review and meta-analysis to assess whether trial duration influenced the relative and absolute risk of worsening in randomized controlled trials (RCT) comparing combination (CT) of PAH-specific therapies versus monotherapy (MT). METHODS: We searched MEDLINE, EMBASE and the Cochrane Library (1/1990 to 9/2016) for RCT assessing CT compared to MT in PAH...
November 23, 2017: Chest
https://www.readbyqxmd.com/read/29171426/pharmacological-induced-target-temperature-management-after-cardiac-arrest-the-capsaicinoids
#18
J Marc Simard, Xiaofeng Jia, Volodymyr Gerzanich
No abstract text is available yet for this article.
October 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29169480/effect-of-a-formalized-research-curriculum-on-fellows-in-training-and-early-career-research-productivity
#19
EDITORIAL
Jeffrey A Marbach, Robert Moreland, Trevor Simard
No abstract text is available yet for this article.
November 28, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29151864/dissecting-functional-components-of-reproductive-isolation-among-closely-related-sympatric-species-of-the-anopheles-gambiae-complex
#20
Marco Pombi, Pierre Kengne, Geoffrey Gimonneau, Billy Tene-Fossog, Diego Ayala, Colince Kamdem, Federica Santolamazza, Wamdaogo Moussa Guelbeogo, N'Falé Sagnon, Vincenzo Petrarca, Didier Fontenille, Nora J Besansky, Christophe Antonio-Nkondjio, Roch Kounbobr Dabiré, Alessandra Della Torre, Frédéric Simard, Carlo Costantini
Explaining how and why reproductive isolation evolves and determining which forms of reproductive isolation have the largest impact on the process of population divergence are major goals in the study of speciation. By studying recent adaptive radiations in incompletely isolated taxa, it is possible to identify barriers involved at early divergence before other confounding barriers emerge after speciation is complete. Sibling species of the Anopheles gambiae complex offer opportunities to provide insights into speciation mechanisms...
December 2017: Evolutionary Applications
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