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https://www.readbyqxmd.com/read/28081518/development-of-a-biometric-method-to-estimate-age-on-hand-radiographs
#1
Floriane Remy, Gabriela Hossu, Romain Cendre, Emilien Micard, Laurence Mainard-Simard, Jacques Felblinger, Laurent Martrille, Loïc Lalys
Age estimation of living individuals aged less than 13, 18 or 21 years, which are some relevant legal ages in most European countries, is currently problematic in the forensic context. Thus, numerous methods are available for legal authorities, although their efficiency can be discussed. For those reasons, we aimed to propose a new method, based on the biometric analysis of hand bones. 451 hand radiographs of French individuals under the age of 21 were retrospectively analyzed. This total sample was divided into three subgroups bounded by the relevant legal ages previously mentioned: 0-13, 13-18 and 18-21 years...
December 23, 2016: Forensic Science International
https://www.readbyqxmd.com/read/28079770/neurodevelopmental-outcomes-after-assisted-reproductive-technologies
#2
Jacques Balayla, Odile Sheehy, William D Fraser, Jean R Séguin, Jacquetta Trasler, Patricia Monnier, Andrea A MacLeod, Marie-Noëlle Simard, Gina Muckle, Anick Bérard
OBJECTIVE: To compare children's cognitive, motor, and language development at 2 years of age after assisted reproductive technologies (ARTs) relative to natural conception. METHODS: The 3D-Study (2010-2012) is a prospective cohort study, which sought to improve the understanding among perinatal events, obstetric outcomes, and child development. A total of 2,366 pregnant women were recruited, of whom 278 conceived with ART: ovarian stimulation, intrauterine sperm insemination, in vitro fertilization, intracytoplasmic sperm injection, or in vitro maturation...
January 9, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28071788/chromosome-inversions-and-ecological-plasticity-in-the-main-african-malaria-mosquitoes
#3
Diego Ayala, Pelayo Acevedo, Marco Pombi, Ibrahima Dia, Daniela Boccolini, Carlo Costantini, Frédéric Simard, Didier Fontenille
Chromosome inversions have fascinated the scientific community, mainly because of their role in the rapid adaption of different taxa to changing environments. However, the ecological traits linked to chromosome inversions have been poorly studied. Here, we investigated the roles played by 23 chromosome inversions in the adaptation of the four major African malaria mosquitoes to local environments in Africa. We studied their distribution patterns by using spatially explicit modeling and characterized the ecogeographical determinants of each inversion range...
January 10, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/28050152/recommendations-on-breast-cancer-screening-and-prevention-in-the-context-of-implementing-risk-stratification-impending-changes-to-current-policies
#4
J Gagnon, E Lévesque, F Borduas, J Chiquette, C Diorio, N Duchesne, M Dumais, L Eloy, W Foulkes, N Gervais, L Lalonde, B L'Espérance, S Meterissian, L Provencher, J Richard, C Savard, I Trop, N Wong, B M Knoppers, J Simard
In recent years, risk stratification has sparked interest as an innovative approach to disease screening and prevention. The approach effectively personalizes individual risk, opening the way to screening and prevention interventions that are adapted to subpopulations. The international perspective project, which is developing risk stratification for breast cancer, aims to support the integration of its screening approach into clinical practice through comprehensive tool-building. Policies and guidelines for risk stratification-unlike those for population screening programs, which are currently well regulated-are still under development...
December 2016: Current Oncology
https://www.readbyqxmd.com/read/28049830/characterization-of-cytopathic-factors-through-genome-wide-analysis-of-the-zika-viral-proteins-in-fission-yeast
#5
Ge Li, Melissa Poulsen, Csaba Fenyvuesvolgyi, Yoko Yashiroda, Minoru Yoshida, J Marc Simard, Robert C Gallo, Richard Y Zhao
The Zika virus (ZIKV) causes microcephaly and the Guillain-Barré syndrome. Little is known about how ZIKV causes these conditions or which ZIKV viral protein(s) is responsible for the associated ZIKV-induced cytopathic effects, including cell hypertrophy, growth restriction, cell-cycle dysregulation, and cell death. We used fission yeast for the rapid, global functional analysis of the ZIKV genome. All 14 proteins or small peptides were produced under an inducible promoter, and we measured the intracellular localization and the specific effects on ZIKV-associated cytopathic activities of each protein...
January 3, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28045336/hyperglycaemia-in-comatose-survivors-of-out-of-hospital-cardiac-arrest
#6
Juan J Russo, Tyler E James, Benjamin Hibbert, F Daniel Ramirez, Trevor Simard, Christina Osborne, Jordan Bernick, George A Wells, Michel R Le May
BACKGROUND: The optimal blood glucose target during the early hospitalisation of comatose survivors of out-of-hospital cardiac arrest (OHCA) has not been established. METHODS: In a retrospective cohort study, we examined clinical outcomes in relation to mean blood glucose during the first 96 hours of hospital admission in comatose survivors of OHCA with an initial shockable rhythm. Mean blood glucose was assessed as a continuous (primary analysis) and categorical variable: <6 mmol/L, 6 to <8 mmol/L and ⩾8 mmol/L...
December 1, 2016: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28039412/cervical-neoplasia-in-systemic-lupus-erythematosus-a-nationwide-study
#7
Hjalmar Wadström, Elizabeth V Arkema, Christopher Sjöwall, Johan Askling, Julia F Simard
OBJECTIVE: The aim was to examine the risk of cervical neoplasia in women with SLE, overall and with respect to treatment, compared with women from the general population. METHODS: By linking national Swedish registers, we assembled a cohort including women with SLE (n = 4976) and matched general population comparators (n = 29 703). Two subcohorts of treated SLE patients were defined on the basis of treatment with antimalarials (n = 1942) and other immunosuppressants (AZA, CYC, ciclosporin, MTX, MMF or rituximab; n = 2175)...
December 30, 2016: Rheumatology
https://www.readbyqxmd.com/read/28033394/correction-gw182-free-microrna-silencing-complex-controls-post-transcriptional-gene-expression-during-caenorhabditis-elegans-embryogenesis
#8
Guillaume Jannot, Pascale Michaud, Miguel Quévillon Huberdeau, Louis Morel-Berryman, James A Brackbill, Sandra Piquet, Katherine McJunkin, Kotaro Nakanishi, Martin J Simard
[This corrects the article DOI: 10.1371/journal.pgen.1006484.].
December 2016: PLoS Genetics
https://www.readbyqxmd.com/read/28013193/medication-use-among-pregnant-women-with-systemic-lupus-erythematosus-and-general-population-comparators
#9
Kristin Palmsten, Julia F Simard, Christina D Chambers, Elizabeth V Arkema
OBJECTIVE: The aim was to characterize SLE medication trends before, during and after pregnancy and to compare other commonly used medications during SLE pregnancies with non-SLE pregnancies. METHODS: Women with pregnancies ending in live birth or stillbirth were identified from the Swedish Medical Birth Register (2006-12). National registers were used to identify women with prevalent SLE during pregnancy and a sample without SLE and to identify prescription medications dispensed from 3 months pre-pregnancy until 6 months postpartum...
December 24, 2016: Rheumatology
https://www.readbyqxmd.com/read/28001399/the-discovery-and-hit-to-lead-optimization-of-tricyclic-sulfonamides-as-potent-and-efficacious-potentiators-of-glycine-receptors
#10
Howard Bregman, Jeffrey R Simard, Kristin L Andrews, Shawn Ayube, Hao Chen, Hakan Gunaydin, Angel Guzman-Perez, Jiali Hu, Liyue Huang, Xin Huang, Paul H Krolikowski, Sonya G Lehto, Richard T Lewis, Klaus Michelsen, Pamela Pegman, Matthew H Plant, Paul L Shaffer, Yohannes Teffera, Shuyan Yi, Maosheng Zhang, Jacinthe Gingras, Erin F DiMauro
Current pain therapeutics suffer from undesirable psychotropic and sedative side effects, as well as abuse potential. Glycine receptors (GlyRs) are inhibitory ligand-gated ion channels expressed in nerves of the spinal dorsal horn, where their activation is believed to reduce transmission of painful stimuli. Herein, we describe the identification and hit-to-lead optimization of a novel class of tricyclic sulfonamides as allosteric GlyR potentiators. Initial optimization of high-throughput screening (HTS) hit 1 led to the identification of 3, which demonstrated ex vivo potentiation of glycine-activated current in mouse dorsal horn neurons from spinal cord slices...
December 21, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27995510/mechanisms-of-global-cerebral-edema-formation-in-aneurysmal-subarachnoid-hemorrhage
#11
Erik G Hayman, Aaron Wessell, Volodymyr Gerzanich, Kevin N Sheth, J Marc Simard
A growing body of clinical literature emphasizes the impact of cerebral edema in early brain injury following aneurysmal subarachnoid hemorrhage (aSAH). Aneurysm rupture itself initiates global cerebral edema in up to two thirds of cases. Although cerebral edema is not a universal feature of aSAH, it portends a poor clinical course, with quantitative analysis revealing a direct correlation between cerebral edema and poor outcome, including mortality and cognitive deficits. Mechanistically, global cerebral edema has been linked to global ischemia at the time of aneurysm rupture, dysfunction of autoregulation, blood breakdown products, neuroinflammation, and hyponatremia/endocrine abnormalities...
December 19, 2016: Neurocritical Care
https://www.readbyqxmd.com/read/27992159/a-non-targeted-uhplc-hrms-metabolomics-pipeline-for-metabolite-identification-application-to-cardiac-remote-ischemic-preconditioning
#12
Judith Kouassi Nzoughet, Cinzia Bocca, Gilles Simard, Delphine Prunier-Mirebeau, Juan Manuel Chao de la Barca, Dominique Bonneau, Vincent Procaccio, Fabrice Prunier, Guy Lenaers, Pascal Reynier
In recent years, the amount of investigations based on non-targeted metabolomics has increased, although often without thorough assessment of analytical strategies applied to acquire data. Following published guidelines for metabolomics experiments, we report a validated non-targeted metabolomics strategy with pipeline for unequivocal metabolites identification using the MSMLS™ molecule library. We achieved an in-house database containing accurate m/z values, retention times, isotopic patterns, full MS and MS/MS spectra...
December 19, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27991902/crystal-structures-of-human-glycine-receptor-%C3%AE-3-bound-to-a-novel-class-of-analgesic-potentiators
#13
Xin Huang, Paul L Shaffer, Shawn Ayube, Howard Bregman, Hao Chen, Sonya G Lehto, Jason A Luther, David J Matson, Stefan I McDonough, Klaus Michelsen, Matthew H Plant, Stephen Schneider, Jeffrey R Simard, Yohannes Teffera, Shuyan Yi, Maosheng Zhang, Erin F DiMauro, Jacinthe Gingras
Current therapies to treat persistent pain and neuropathic pain are limited by poor efficacy, side effects and risk of addiction. Here, we present a novel class of potent selective, central nervous system (CNS)-penetrant potentiators of glycine receptors (GlyRs), ligand-gated ion channels expressed in the CNS. AM-1488 increased the response to exogenous glycine in mouse spinal cord and significantly reversed mechanical allodynia induced by nerve injury in a mouse model of neuropathic pain. We obtained an X-ray crystal structure of human homopentameric GlyRα3 in complex with AM-3607, a potentiator of the same class with increased potency, and the agonist glycine, at 2...
December 19, 2016: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/27965354/complementary-and-alternative-medicine-do-physicians-believe-they-can-meet-the-requirements-of-the-coll%C3%A3-ge-des-m%C3%A3-decins-du-qu%C3%A3-bec
#14
Isabelle Gaboury, Noémie Johnson, Christine Robin, Mireille Luc, Daniel O'Connor, Johane Patenaude, Luce Pélissier-Simard, Marianne Xhignesse
OBJECTIVE: To determine whether medical training prepares FPs to meet the requirements of the Collège des médecins du Québec for their role in advising patients on the use of complementary and alternative medicine (CAM). DESIGN: Secondary analysis of survey results. SETTING: Quebec. PARTICIPANTS: Family physicians and GPs in active practice. MAIN OUTCOME MEASURES: Perceptions of the role of the physician as an advisor on CAM; level of comfort responding to questions and advising patients on CAM; frequency with which patients ask their physicians about CAM; personal position on CAM; and desire for training on CAM...
December 2016: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/27965353/m%C3%A3-decines-alternatives-et-compl%C3%A3-mentaires-les-m%C3%A3-decins-se-consid%C3%A3-rent-ils-en-mesure-de-r%C3%A3-pondre-aux-exigences-du-coll%C3%A3-ge-des-m%C3%A3-decins-du-qu%C3%A3-bec
#15
Isabelle Gaboury, Noémie Johnson, Christine Robin, Mireille Luc, Daniel O'Connor, Johane Patenaude, Luce Pélissier-Simard, Marianne Xhignesse
No abstract text is available yet for this article.
December 2016: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/27943386/early-onset-preeclampsia-in-lupus-pregnancy
#16
Julia F Simard, Elizabeth V Arkema, Cathina Nguyen, Elisabet Svenungsson, Anna-Karin Wikström, Kristin Palmsten, Jane E Salmon
BACKGROUND: Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease that occurs during childbearing years and has been associated with preeclampsia. However, little is known about preeclampsia of early onset, which is associated with severe adverse maternal and perinatal outcomes. METHODS: Using national population-based Swedish registers we identified women with SLE (≥2 visits with corresponding ICD codes) and a sample without SLE who gave birth to singleton infants 2001-12...
January 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/27935964/gw182-free-microrna-silencing-complex-controls-post-transcriptional-gene-expression-during-caenorhabditis-elegans-embryogenesis
#17
Guillaume Jannot, Pascale Michaud, Miguel Quévillon Huberdeau, Louis Morel-Berryman, James A Brackbill, Sandra Piquet, Katherine McJunkin, Kotaro Nakanishi, Martin J Simard
MicroRNAs and Argonaute form the microRNA induced silencing complex or miRISC that recruits GW182, causing mRNA degradation and/or translational repression. Despite the clear conservation and molecular significance, it is unknown if miRISC-GW182 interaction is essential for gene silencing during animal development. Using Caenorhabditis elegans to explore this question, we examined the relationship and effect on gene silencing between the GW182 orthologs, AIN-1 and AIN-2, and the microRNA-specific Argonaute, ALG-1...
December 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27931260/prediction-of-breast-cancer-risk-based-on-common-genetic-variants-in-women-of-east-asian-ancestry
#18
Wanqing Wen, Xiao-Ou Shu, Xingyi Guo, Qiuyin Cai, Jirong Long, Manjeet K Bolla, Kyriaki Michailidou, Joe Dennis, Qin Wang, Yu-Tang Gao, Ying Zheng, Alison M Dunning, Montserrat García-Closas, Paul Brennan, Shou-Tung Chen, Ji-Yeob Choi, Mikael Hartman, Hidemi Ito, Artitaya Lophatananon, Keitaro Matsuo, Hui Miao, Kenneth Muir, Suleeporn Sangrajrang, Chen-Yang Shen, Soo H Teo, Chiu-Chen Tseng, Anna H Wu, Cheng Har Yip, Jacques Simard, Paul D P Pharoah, Per Hall, Daehee Kang, Yongbing Xiang, Douglas F Easton, Wei Zheng
BACKGROUND: Approximately 100 common breast cancer susceptibility alleles have been identified in genome-wide association studies (GWAS). The utility of these variants in breast cancer risk prediction models has not been evaluated adequately in women of Asian ancestry. METHODS: We evaluated 88 breast cancer risk variants that were identified previously by GWAS in 11,760 cases and 11,612 controls of Asian ancestry. SNPs confirmed to be associated with breast cancer risk in Asian women were used to construct a polygenic risk score (PRS)...
December 8, 2016: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/27926494/p38-and-jnk-pathways-control-e-selectin-dependent-extravasation-of-colon-cancer-cells-by-modulating-mir-31-transcription
#19
Liang Zhong, Bryan Simoneau, Jacques Huot, Martin J Simard
Extravasation of circulating cancer cells is a key event of metastatic dissemination that is initiated by the adhesion of cancer cells to vascular endothelial cells. It requires the interaction between adhesion receptors such as E-selectin present on endothelial cells and their ligands on cancer cells. Notably, E-selectin influences the metastatic potential of breast, bladder, gastric, pancreatic, and colorectal carcinoma as well as of leukemia and lymphoma. Here, we show that E-selectin expression induced by the pro-inflammatory cytokine IL-1β is directly and negatively regulated by miR-31...
December 2, 2016: Oncotarget
https://www.readbyqxmd.com/read/27914442/analysis-and-modeling-of-255-source-levels-of-merchant-ships-from-an-acoustic-observatory-along-st-lawrence-seaway
#20
Yvan Simard, Nathalie Roy, Cédric Gervaise, Samuel Giard
An ensemble of 255 spectral source levels (SSLs) of merchant ships were measured with an opportunistic seaway acoustic observatory adhering to the American National Standards Institute/Acoustical Society of America S12.64-2009 standard as much as possible, and deployed in the 350-m deep lower St. Lawrence Seaway in eastern Canada. The estimated SSLs were sensitive to the transmission loss model. The best transmission loss model at the three measuring depths was an empirical in situ function for ranges larger than 300 m, fused with estimates from a wavenumber integration propagation model fed with inverted local geoacoustic properties for [300 to 1 m] ranges...
September 2016: Journal of the Acoustical Society of America
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