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JOURNAL ARTICLE
Carolanne Caron, Shellyza Sajwani, Katherine Bateman, Owen Degenhardt, Mathilde Gaudreau-Simard, Smita Pakhale, Salmaan Kanji
BACKGROUND: The carbon footprint of Canada's health sector is among the worst in the world, responsible for 4·6% of Canada's total greenhouse gas emissions. A quarter of emissions from Canada's health sector are linked to pharmaceuticals, including metered dose inhalers (MDIs). MDIs use propellants, such as hydrofluorocarbons, which act as greenhouse gas emissions and contribute to the health-care sector's overall carbon footprint. The objective of this study was to describe MDI prescribing, dispensing, usage, and waste patterns at The Ottawa Hospital (Ottawa, ON, Canada)...
April 2024: Lancet. Planetary Health
#2
JOURNAL ARTICLE
Elisabeth Thibaudeau, Tania Lecomte, Marc Corbière, Amal Abdel-Baki, Andréanne Simard, Marc-André Roy, Caroline Cellard
INTRODUCTION: Psychotic disorders are associated with academic difficulties. Supported Employment Program (SEP) guidelines have become the gold standard to improve occupational functioning in psychotic disorders. More recently, these guidelines have been adapted to education. In Canada, several community organizations and hospital programs offer supported education to young people with psychotic disorders. However, SEP guidelines are not systematically used. The objective of this study was to assess the fidelity of 6 Canadian (Quebec) organizations offering supported education services to young people with psychotic disorders to the SEP guidelines adapted to education...
April 16, 2024: Early Intervention in Psychiatry
#3
JOURNAL ARTICLE
Pierre-Marc Frédérick, Guillaume Jannot, Isabelle Banville, Martin J Simard
MicroRNAs (miRNAs) are essential regulators of several biological processes. They are loaded onto Argonaute (AGO) proteins to achieve their repressive function, forming the microRNA-Induced Silencing Complex known as miRISC. While several AGO proteins are expressed in plants and animals, it is still unclear why specific AGOs are strictly binding miRNAs. Here, we identified the co-chaperone DNJ-12 as a new interactor of ALG-1, one of the two major miRNA-specific AGOs in Caenorhabditis elegans. DNJ-12 does not interact with ALG-2, the other major miRNA-specific AGO, and PRG-1 and RDE-1, two AGOs involved in other small RNA pathways, making it a specific actor in ALG-1-dependent miRNA-mediated gene silencing...
April 13, 2024: Nucleic Acids Research
#4
JOURNAL ARTICLE
D Grannas, J F Simard, E Svenungsson, E V Arkema, Sam Gernaat
OBJECTIVE: To investigate sickness benefits following delivery in mothers with systemic lupus erythematosus (SLE) and mothers without SLE. METHOD: SLE and non-SLE mothers, matched by age and month of delivery, with a singleton liveborn (2004-2008), were identified from the Swedish Lupus Linkage cohort. Work loss (sum of sick leave and disability pension) was studied from 1 year prenatally to 3 years postpartum. Adjusted logistic regression models of covariates associated with > 30 days of work loss in the first and second years postpartum were estimated in SLE mothers...
May 2024: Scandinavian Journal of Rheumatology
#5
JOURNAL ARTICLE
Marcus A Urey, Benjamin Hibbert, Ulrich Jorde, Peter Eckman, Trevor Simard, Marino Labinaz, Babak Nazer, Mark Wiley, Bhanu Gupta, Andrew Sauer, Hirak Shah, Paul Sorajja, Andres M Pineda, Emil Missov, Ehtisham Mahmud, Rami Kahwash, Scott Lilly, Azeem Latib, Sandhya Murthy, Neil Fam, Santiago Garcia, Eugene S Chung, Liviu Klein, Richard Cheng, Brian A Houston, Nicholas S Amoroso, Lee Chang, Sameer Gafoor, Sunit-Preet Chaudhry, James Hermiller, Jonathan G Schwartz, Lillian Aldaia, Konstantinos Koulogiannis, William A Gray, Firas Zahr
AIMS: Patients with heart failure and mildly reduced or preserved ejection fraction have limited therapeutic options. The ALT-FLOW Early Feasibility Study evaluated safety, haemodynamics and outcomes for the APTURE transcatheter shunt system, a novel left atrium to coronary sinus shunt in these patients. METHODS AND RESULTS: Safety and shunt implantation success was evaluated for all 116 enrolled patients. An analysis population of implanted patients with a left ventricular ejection fraction (LVEF) >40% (n = 95) was chosen to assess efficacy via paired comparison between baseline and follow-up haemodynamic (3 and 6 months), and echocardiographic, clinical and functional outcomes (6 months and 1 year)...
April 12, 2024: European Journal of Heart Failure
#6
REVIEW
How to measure patient and family important outcomes in extremely preterm infants: A scoping review.
Anne Synnes, Mei Mei Lam, M Florencia Ricci, Paige Church, Marie-Noelle Simard, Jill G Zwicker, Thuy Mai Luu
AIM: Parents of children born preterm have identified outcomes to be measured for audit and research at 18-24 months of age: child well-being, quality of life/function, socio-emotional/behavioural outcomes, respiratory, feeding, sleeping, and caregiver mental health. The aim was to identify the best tools to measure these seven domains. METHODS: Seven working groups completed literature reviews and evaluated potential tools to measure these outcomes in children aged 18-24 months...
April 5, 2024: Acta Paediatrica
#7
JOURNAL ARTICLE
Christian Renaud, Antoine Lewin, Yves Gregoire, Nathalie Simard, Émilie Vallières, Maude Paquette, Steven J Drews, Sheila F O'Brien, Clara Di Germanio, Michael P Busch, Marc Germain, Renée Bazin
BACKGROUND AND OBJECTIVES: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serosurveys are typically analysed by applying a fixed threshold for seropositivity ('conventional approach'). However, this approach underestimates the seroprevalence of anti-nucleocapsid (N) in vaccinated individuals-who often exhibit a difficult-to-detect anti-N response. This limitation is compounded by delays between the onset of infection and sample collection. To address this issue, we compared the performance of four immunoassays using a new analytical approach ('ratio-based approach'), which determines seropositivity based on an increase in anti-N levels...
April 5, 2024: Vox Sanguinis
#8
JOURNAL ARTICLE
Pascale Simard, Samuel Turcotte, Catherine Vallée, Marie-Eve Lamontagne
Background The strengths-based approach (SBA) was initially developed for people living with mental health issues but may represent a promising support option for community participation of people living with a traumatic brain injury (TBI). A community-based organisation working with people living with TBI is in the process of adapting this approach to implement it in their organisation. No studies explored an SBA implementation with this population. This study explores the implementation of key components of the SBA in a community-based organisation dedicated to people living with TBI...
February 2024: Brain Impairment: a Multidisciplinary Journal of the Australian Society for the Study of Brain Impairment
#9
REVIEW
J Marc Simard, Bradley Wilhelmy, Natalya Tsymbalyuk, Bosung Shim, Jesse A Stokum, Madison Evans, Anandita Gaur, Cigdem Tosun, Kaspar Keledjian, Prajwal Ciryam, Riccardo Serra, Volodymyr Gerzanich
In human stroke, brain swelling is an important predictor of neurological outcome and mortality, yet treatments to reduce or prevent brain swelling are extremely limited, due in part to an inadequate understanding of mechanisms. In preclinical studies on cerebroprotection in animal models of stroke, historically, the focus has been on reducing infarct size, and in most studies, a reduction in infarct size has been associated with a corresponding reduction in brain swelling. Unfortunately, such findings on brain swelling have little translational value for treating brain swelling in patients with stroke...
February 28, 2024: Brain Sciences
#10
JOURNAL ARTICLE
Michael S Golinko, Odette Abou-Ghanem, Michael Simard, Mike Caudill, Matthew E Pontell, Nick O'Sick, Brandon Oglesby, Mark Arrieta
STATEMENT OF THE PROBLEM: Standardized medical photography of the face is a vital part of patient documentation, clinical evaluation, and scholarly dissemination. Because digital photography is a mainstay in clinical care, there is a critical need for an easy-to-use mobile device application that could assist users in taking a standardized clinical photograph. ImageAssist was developed to answer this need. The mobile application is integrated into the electronic medical record (EMR); it implements and automates American Society of Plastic Surgery/Plastic Surgery Research Foundation photographic guidelines with background deletion...
April 1, 2024: Annals of Plastic Surgery
#11
JOURNAL ARTICLE
Shreyas Bhat, Justine Rousseau, Coralie Michaud, Charles Marques Lourenço, Joan M Stoler, Raymond J Louie, Lola K Clarkson, Angie Lichty, Daniel C Koboldt, Shalini C Reshmi, Sanjay M Sisodiya, Eva M M Hoytema van Konijnenburg, Klaas Koop, Peter M van Hasselt, Florence Démurger, Christèle Dubourg, Bonnie R Sullivan, Susan S Hughes, Isabelle Thiffault, Elisabeth Simard Tremblay, Andrea Accogli, Myriam Srour, Rikard Blunck, Philippe M Campeau
Ion channels mediate voltage fluxes or action potentials that are central to the functioning of excitable cells such as neurons. The KCNB family of voltage-gated potassium channels (Kv) consists of two members (KCNB1 and KCNB2) encoded by KCNB1 and KCNB2, respectively. These channels are major contributors to delayed rectifier potassium currents arising from the neuronal soma which modulate overall excitability of neurons. In this study, we identified several mono-allelic pathogenic missense variants in KCNB2, in individuals with a neurodevelopmental syndrome with epilepsy and autism in some individuals...
March 13, 2024: American Journal of Human Genetics
#12
JOURNAL ARTICLE
Suzie Ouellet, Sandrine Hamel, Camille Simard, Maral Koolian, Antony Robert, Karen Wou, Stéphanie Lam, Amal Bessissow, Sarah St-Georges, Vicky Tagalakis, Alexandra de Pokomandy, Linda Snell, Ning-Zi Sun, Isabelle Malhamé
BACKGROUND: Computed tomography pulmonary angiogram and lung scintigraphy with ventilation/perfusion scan are needed to diagnose pulmonary embolism (PE) in pregnancy. Their associated ionizing radiation doses are considered safe in pregnancy. A standardized patient information tool may improve patient counseling and reduce testing hesitancy. OBJECTIVES: In this context, we sought to address 1) what patients want to know before undergoing these tests and 2) how they want the information to be provided to them...
February 2024: Research and Practice in Thrombosis and Haemostasis
#13
Daniel R Barnes, Jonathan P Tyrer, Joe Dennis, Goska Leslie, Manjeet K Bolla, Michael Lush, Amber M Aeilts, Kristiina Aittomäki, Nadine Andrieu, Irene L Andrulis, Hoda Anton-Culver, Adalgeir Arason, Banu K Arun, Judith Balmaña, Elisa V Bandera, Rosa B Barkardottir, Lieke P V Berger, Amy Berrington de Gonzalez, Pascaline Berthet, Katarzyna Białkowska, Line Bjørge, Amie M Blanco, Marinus J Blok, Kristie A Bobolis, Natalia V Bogdanova, James D Brenton, Henriett Butz, Saundra S Buys, Maria A Caligo, Ian Campbell, Carmen Castillo, Kathleen B M Claes, Sarah V Colonna, Linda S Cook, Mary B Daly, Agnieszka Dansonka-Mieszkowska, Miguel de la Hoya, Anna deFazio, Allison DePersia, Yuan Chun Ding, Susan M Domchek, Thilo Dörk, Zakaria Einbeigi, Christoph Engel, D Gareth Evans, Lenka Foretova, Renée T Fortner, Florentia Fostira, Maria Cristina Foti, Eitan Friedman, Megan N Frone, Patricia A Ganz, Aleksandra Gentry-Maharaj, Gord Glendon, Andrew K Godwin, Anna González-Neira, Mark H Greene, Jacek Gronwald, Aliana Guerrieri-Gonzaga, Ute Hamann, Thomas V O Hansen, Holly R Harris, Jan Hauke, Florian Heitz, Frans B L Hogervorst, Maartje J Hooning, John L Hopper, Chad D Huff, David G Huntsman, Evgeny N Imyanitov, Louise Izatt, Anna Jakubowska, Paul A James, Ramunas Janavicius, Esther M John, Siddhartha Kar, Beth Y Karlan, Catherine J Kennedy, Lambertus A L M Kiemeney, Irene Konstantopoulou, Jolanta Kupryjanczyk, Yael Laitman, Ofer Lavie, Kate Lawrenson, Jenny Lester, Fabienne Lesueur, Carlos Lopez-Pleguezuelos, Phuong L Mai, Siranoush Manoukian, Taymaa May, Iain A McNeish, Usha Menon, Roger L Milne, Francesmary Modugno, Jennifer M Mongiovi, Marco Montagna, Kirsten B Moysich, Susan L Neuhausen, Finn C Nielsen, Catherine Noguès, Edit Oláh, Olufunmilayo I Olopade, Ana Osorio, Laura Papi, Harsh Pathak, Celeste L Pearce, Inge S Pedersen, Ana Peixoto, Tanja Pejovic, Pei-Chen Peng, Beth N Peshkin, Paolo Peterlongo, C Bethan Powell, Darya Prokofyeva, Miquel Angel Pujana, Paolo Radice, Muhammad U Rashid, Gad Rennert, George Richenberg, Dale P Sandler, Naoko Sasamoto, Veronica W Setiawan, Priyanka Sharma, Weiva Sieh, Christian F Singer, Katie Snape, Anna P Sokolenko, Penny Soucy, Melissa C Southey, Dominique Stoppa-Lyonnet, Rebecca Sutphen, Christian Sutter, Manuel R Teixeira, Kathryn L Terry, Liv Cecilie V Thomsen, Marc Tischkowitz, Amanda E Toland, Toon Van Gorp, Ana Vega, Digna R Velez Edwards, Penelope M Webb, Jeffrey N Weitzel, Nicolas Wentzensen, Alice S Whittemore, Stacey J Winham, Anna H Wu, Siddhartha Yadav, Yao Yu, Argyrios Ziogas, Andrew Berchuck, Fergus J Couch, Ellen L Goode, Marc T Goodman, Alvaro N Monteiro, Kenneth Offit, Susan J Ramus, Harvey A Risch, Joellen M Schildkraut, Mads Thomassen, Jacques Simard, Douglas F Easton, Michelle R Jones, Georgia Chenevix-Trench, Simon A Gayther, Antonis C Antoniou, Paul D P Pharoah
BACKGROUND: Nineteen genomic regions have been associated with high-grade serous ovarian cancer (HGSOC). We used data from the Ovarian Cancer Association Consortium (OCAC), Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA), UK Biobank (UKBB), and FinnGen to identify novel HGSOC susceptibility loci and develop polygenic scores (PGS). METHODS: We analyzed >22 million variants for 398,238 women. Associations were assessed separately by consortium and meta-analysed...
March 4, 2024: medRxiv
#14
JOURNAL ARTICLE
Tiffany E Jiang, Alissa P Pascual, Nathan Le, Thy B Nguyen, Sean Mackey, Beth D Darnall, Julia F Simard, Titilola Falasinnu
INTRODUCTION: Patients with systemic lupus erythematosus (SLE) bear a significant burden of pain. We aimed to identify factors that distinguish patients with SLE referred to comprehensive pain clinics and those who are not. Characterizing this patient population will identify unmet needs in SLE management and inform efforts to improve pain care in rheumatology. METHODS: Among patients with SLE with ≥2 rheumatology clinic visits in a large hospital system from 1998 to 2023 (n = 1319), we examined factors that distinguished those who had at least one visit to multidisciplinary pain clinics (n = 77, 5...
March 16, 2024: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
#15
JOURNAL ARTICLE
Laurie-Anne Boivin-Proulx, Fabrice Ieroncig, Simon-Pierre Demers, Anna Nozza, Marwa Soltani, Ismahane Ghersi, Louis Verreault-Julien, Yahya Alansari, Charles Massie, Philippe Simard, Lorena Rosca, Jean-Simon Lalancette, Gabriel Massicotte, Annabel Chen-Tournoux, Benoit Daneault, Jean-Michel Paradis, Jean G Diodati, Nicolas Pranno, Marc Jolicoeur, Brian J Potter, Guillaume Marquis-Gravel, Christine Pacheco
BACKGROUND: In patients with anterior ST-elevation myocardial infarction (STEMI) and new-onset antero-apical wall motion abnormalities (WMAs), whether the rate of prophylaxis against left ventricular thrombus and outcomes differ between men and women is unknown. METHODS: A multicentre retrospective cohort study of patients with STEMI and new-onset antero-apical WMAs treated with primary percutaneous coronary intervention was conducted. Patients with an established indication of oral anticoagulation (OAC) were excluded...
February 2024: CJC open
#16
JOURNAL ARTICLE
Ngoc V Nguyen, Elisabet Svenungsson, Annica Dominicus, Maria Altman, Karin Hellgren, Julia F Simard, Elizabeth V Arkema
OBJECTIVES: To assess the infant risk of major congenital malformations (MCM) associated with first-trimester exposure to hydroxychloroquine (HCQ) among mothers with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA). METHODS: This population-based cohort study utilised Swedish nationwide registers and included all singleton births (2006-2021) among individuals with prevalent SLE or RA in Sweden. The exposure was filling ≥1 HCQ prescription during the first trimester...
March 13, 2024: Rheumatology
#17
JOURNAL ARTICLE
Anisha Pal, Vaishnav Vasudevan, François Houle, Michael Lantin, Katherine A Maniates, Miguel Quévillon Huberdeau, Allison L Abbott, Martin J Simard
microRNAs regulate gene expression through interaction with an Argonaute protein. While some members of this protein family retain an enzymatic activity capable of cleaving RNA molecules complementary to Argonaute-bound small RNAs, the role of the slicer residues in the canonical microRNA pathway is still unclear in animals. To address this, we created Caenorhabditis elegans strains with mutated slicer residues in the endogenous ALG-1 and ALG-2, the only two slicing Argonautes essential for the miRNA pathway in this animal model...
March 13, 2024: Nucleic Acids Research
#18
JOURNAL ARTICLE
Eric Saloux, Morgane Le Garrec, Nina Menet, Ludovic Dillon, Christophe Simard, Christophe Fraschini, Alain Manrique
OBJECTIVE: The purpose of this study was to assess cardiac shear wave imaging implemented in a new MACH 30 ultrasound machine (SuperSonic Imaging, Aix-en-Provence, France) and interfaced with a linear probe and a phased array probe, in comparison with a previously validated Aixplorer system connected to a linear probe (SuperSonic Imaging) using Elasticity QA phantoms (Models 039 and 049, CIRS Inc., Norfolk, VA, USA). METHODS: Quantile-quantile plots were used for distribution agreement...
March 11, 2024: Ultrasound in Medicine & Biology
#19
JOURNAL ARTICLE
Florence Fournet, Frédéric Simard, Didier Fontenille
Aligned with the Sustainable Development Goals, nature-based solutions such as urban greening e.g. public gardens, urban forests, parks and street trees, which aim to protect, sustainably manage or restore an ecosystem, have emerged as a promising tool for improving the health and well-being of an ever-increasing urban population. While urban greening efforts have undeniable benefits for human health and the biological communities inhabiting these green zones, disease vector populations may also be affected, possibly promoting greater pathogen transmission and the emergence of infectious diseases such as dengue, West Nile fever, malaria, leishmaniosis and tick-borne diseases...
March 2024: Euro Surveillance
#20
JOURNAL ARTICLE
Husein Moloo, Mathilde Gaudreau-Simard, Claire Kendall, Gordon Best, Nieve Seguin, Bernard J Jasmin, Mark Walker
No abstract text is available yet for this article.
March 2024: Lancet. Planetary Health
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