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https://www.readbyqxmd.com/read/29684464/tracking-single-membrane-targets-of-human-autoantibodies-using-single-nanoparticle-imaging
#1
Julie Jézéquel, Julien P Dupuis, François Maingret, Laurent Groc
BACKGROUND: Over the past decade, an increasing number of neurological and neuropsychiatric diseases have been associated with the expression of autoantibodies directed against neuronal targets, including neurotransmitter receptors. Although cell-based assays are routinely used in clinics to detect the presence of immunoglobulins, such tests often provide heterogeneous outcomes due to their limited sensitivity, especially at low titers. Thus, there is an urging need for new methods allowing the detection of autoantibodies in seropositive patients that cannot always be clinically distinguished from seronegative ones...
April 20, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29683886/a-modern-comparison-of-urodynamic-findings-in-diabetic-versus-nondiabetic-women
#2
Rena D Malik, Joshua A Cohn, Jessica Volsky, Sarah Garvey, Charles Chang, Gregory T Bales, Doreen E Chung
OBJECTIVES: Few contemporary studies exist regarding urodynamic (UDS) findings in patients with diabetes mellitus (DM), and data are conflicting. Our aim was to compare UDS findings in women with and without DM. METHODS: Data from female patients in a prospectively maintained UDS database (2010-2014) were reviewed. Studies were performed according to International Continence Society standards. Clinical data, presenting symptoms, and UDS findings were compared in women with and without DM, controlling for demographic and pertinent variables...
April 20, 2018: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29683495/now-you-hear-it-a-predictive-coding-model-for-understanding-rhythmic-incongruity
#3
Peter Vuust, Martin J Dietz, Maria Witek, Morten L Kringelbach
Rhythmic incongruity in the form of syncopation is a prominent feature of many contemporary musical styles. Syncopations afford incongruity between rhythmic patterns and the meter, giving rise to mental models of differently accented isochronous beats. Syncopations occur either in isolation or as part of rhythmic patterns, so-called grooves. On the basis of the predictive coding framework, we discuss how brain processing of rhythm can be seen as a special case of predictive coding. We present a simple, yet powerful model for how the brain processes rhythmic incongruity: the model for predictive coding of rhythmic incongruity...
April 23, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29681081/what-makes-a-word-so-attractive-disclosing-the-urge-to-read-while-bisecting
#4
Luisa Girelli, Paola Previtali, Lisa S Arduino
Expert readers have been repeatedly reported to misperceive the centre of visual stimuli, shifting systematically to the left the bisection of any lines (pseudoneglect) while showing a cross-over effect while bisecting different types of orthographic strings (Arduino et al., 2010, Neuropsychologia, 48, 2140). This difference has been attributed to asymmetrical allocation of attention that visuo-verbal material receives when lexical access occurs (e.g., Fischer, 2004, Cognitive Brain Research, 4, 163). The aim of this study was to further examine which visual features guide recognition of potentially orthographic materials...
April 22, 2018: British Journal of Psychology
https://www.readbyqxmd.com/read/29679824/extended-producer-responsibility-and-corporate-performance-effects-of-environmental-regulation-and-environmental-strategy
#5
Benhong Peng, Yu Tu, Ehsan Elahi, Guo Wei
While contemporary manufacturing technologies stimulate the industrial revolution and promote the rapidly changing global economy, it has caused enormous environmental negative externalities and managing the industrial waste remains a primary challenge, especially for fast developing countries such as China. Though existing studies explored the influence of Extended Producer Responsibility (EPR) legislations on environmental externalities, only fewer researches aimed at policy issues. Particularly, the relationship among environmental regulations, environmental strategies and corporate performance in the EPR system has not been deeply investigated...
April 18, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29673723/marijuana-use-by-adolescents-and-young-adults-with-inflammatory-bowel-disease
#6
Edward J Hoffenberg, Shannon K McWilliams, Susan K Mikulich-Gilbertson, Brittany V Murphy, Megan Lagueux, Kristen Robbins, Analice S Hoffenberg, Edwin de Zoeten, Christian J Hopfer
OBJECTIVE: To evaluate marijuana use by adolescents and young adults with inflammatory bowel disease (IBD). STUDY DESIGN: This descriptive cross-sectional study of patients seen between December 2015 through June 2017 at Children's Hospital Colorado for IBD enrolled patients 13-23 years of age, independent of marijuana use status. Information obtained consisted of chart review, electronic and interview self-report, and serum cannabinoid levels. Marijuana ever-users were compared with never-users for clinical characteristics and perceptions of risk with use; users provided information on routes, patterns, motivations, and perceived benefits and problems with use...
April 16, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29673676/did-surgical-failure-and-complications-affect-incontinence-related-quality-of-life-in-women-after-transobturator-sling-procedure
#7
Wen-Chu Huang, Hui-Hsuan Lau, Tsung-Hsien Su
OBJECTIVE: To report the objective outcome, subjective measurement of incontinence-related quality of life (QoL) for female urodynamic stress incontinence (USI) after transobturator sling surgery (TVT-O) and to evaluate the effects of surgical failure and complications on QoL. MATERIALS AND METHODS: We analyzed the data from women who underwent TVT-O for USI and completed two validated QoL questionnaires, the Urogenital Distress Inventory (UDI-6) and Incontinence Impact Questionnaire (IIQ-7) preoperatively and at least 12 months postoperatively...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29672530/development-of-an-effective-virtual-environment-in-eliciting-craving-in-adolescents-and-young-adults-with-internet-gaming-disorder
#8
Yu-Bin Shin, Jae-Jin Kim, Min-Kyeong Kim, Sunghyon Kyeong, Young Hoon Jung, Hyojung Eom, Eunjoo Kim
Internet gaming disorder (IGD) is a new disorder that warrants further investigation, as recently noted in the research criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. Offering controlled environments that increase cue-induced craving, virtual reality cue-exposure therapy has been shown to be effective for some addiction disorders. To assess the feasibility of virtual reality for patients with IGD, this study aimed to develop virtual environments that represent risk situations for inducing craving, and assess the effect of virtual reality in cue reactivity...
2018: PloS One
https://www.readbyqxmd.com/read/29671859/community-dissemination-in-a-tribal-health-setting-a-pharmacogenetics-case-study
#9
Julie A Beans, Vanessa Y Hiratsuka, Charlene R Apok, Karen Caindec, Denise A Dillard, Renee F Robinson
Alaska Native and American Indian (AN/AI) people experience a disproportionate burden of health disparities in the United States. Including AN/AI people in pharmacogenetic research offers an avenue to address these health disparities, however the dissemination of pharmacogenetic research results in the community context can be a challenging task. In this paper, we describe a case-study that explores the preferences of AN/AI community members regarding pharmacogenetic research results dissemination. Results were presented as a PowerPoint presentation at the 2016 Alaska Native Health Research Forum (Forum)...
2018: American Indian and Alaska Native Mental Health Research: the Journal of the National Center
https://www.readbyqxmd.com/read/29671584/tailored-polyproteins-using-sequential-staple-and-cut
#10
Surbhi Garg, Gayathri S Singaraju, Sunanda Yengkhom, Sabyasachi Rakshit
Polyproteins, individual protein units joined covalently in tandem, have been evolved as a promising tool for measuring the dynamic folding of bio-macromolecules in single-molecule force spectroscopy. However, the synthetic routes of preparing polyproteins have been a bottleneck, and urge for developing in-vitro methods to knit individual protein units covalently into polyprotein. Employing two enzymes of orthogonal functionalities periodically in sequence, we synthesized monodispersed polyproteins on a solid surface...
April 19, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29669135/society-of-behavioral-medicine-position-statement-retain-school-meal-standards-and-healthy-school-lunches
#11
Joanna Buscemi, Angela Odoms-Young, Amy L Yaroch, Laura L Hayman, Bernardo Loiacono, Annie Herman, Marian L Fitzgibbon
In 2010, the Healthy, Hunger-Free Kids Act (HHFKA) altered nutrition standards in the U.S. National School Lunch Program in an attempt to promote healthy eating and improve children's overall health. However, it was reported that these nutrition standard changes were leading to lower consumption of meals and an increase in plate waste. Initial research was unable to validate these reports. Despite these unsubstantiated claims, the U.S. Department of Agriculture released a proposal to roll back some of the nutritional standards implemented by the HHFKA in 2017...
April 13, 2018: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/29667796/isotretinoin-the-ups-are-just-as-troubling-as-the-downs
#12
Jay M Truitt, Jason S Reichenberg, Kevin G Sharghi, Shirlene M Sampson, Randall K Roenigk, Michelle Magid
INTRODUCTION: Isotretinoin, previously marketed as Accutane®, is an oral retinoid medication that is used to treat acne and other cutaneous disorders. Although the data is conflicting, previous reports suggest a causal relationship between isotretinoin and depression. When reviewing these previous reports, many patients who were diagnosed as 'depressed' did not undergo a thorough psychiatric evaluation and/or were not diagnosed according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSM)...
April 18, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29665561/the-functions-and-addictive-features-of-non-suicidal-self-injury-a-confirmatory-factor-analysis-of-the-ottawa-self-injury-inventory-in-a-university-sample
#13
Camille Guérin-Marion, Jodi Martin, Audrey-Ann Deneault, Marie-France Lafontaine, Jean-François Bureau
The Ottawa Self-Injury Inventory (OSI) is a comprehensive self-report measure of non-suicidal self-injury (NSSI). In an effort to build on past research and further validate the OSI, this study presents a confirmatory factor analysis of the OSI's subscales measuring the functions and addictive features of NSSI using a university sample. Participants were 316 university students aged 17-25 years (84.8% female) who had engaged in NSSI at least once in their lifetime. Consistent with past research, results confirmed the four-factor structure of the Functions items (Internal Emotion Regulation, Social Influence, External Emotion Regulation, Sensation Seeking), as well as the single-factor structure of Addictive Features items...
April 7, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29662095/%C3%AE-opioid-receptor-system-mediates-reward-processing-in-humans
#14
Lauri Nummenmaa, Tiina Saanijoki, Lauri Tuominen, Jussi Hirvonen, Jetro J Tuulari, Pirjo Nuutila, Kari Kalliokoski
The endogenous μ-opioid receptor (MOR) system regulates motivational and hedonic processing. We tested directly whether individual differences in MOR are associated with neural reward responses to food pictures in humans. We scanned 33 non-obese individuals with positron emission tomography (PET) using the MOR-specific radioligand [11 C]carfentanil. During a functional magnetic resonance imaging (fMRI) scan, the subjects viewed pictures of appetizing versus bland foods to elicit reward responses. MOR availability was measured in key components of the reward and emotion circuits and used to predict BOLD-fMRI responses to foods...
April 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29661209/gastrointestinal-and-urinary-complaints-in-adults-with-hereditary-spastic-paraparesis
#15
Øivind J Kanavin, Krister W Fjermestad
BACKGROUND: Hereditary spastic paraparesis (HSP) is a group of rare genetic disorders affecting the central nervous system. Pure HSP is limited to lower limb spasticity and urinary voiding dysfunction. Complex HSP involves additional neurological features. Beyond the described core symptoms, knowledge about the burden of disease for adults with HSP is limited, particularly regarding gastrointestinal functions, fecal incontinence, and urinary symptoms. METHODS: We conducted a cross-sectional self-report survey with 108 adult HSP patients (Mage  = 57...
April 16, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29659780/health-outcomes-for-clients-of-needle-and-syringe-programs-in-prisons
#16
Jeffrey V Lazarus, Kelly Safreed-Harmon, Kristina L Hetherington, Daniel J Bromberg, Denise Ocampo, Niels Graf, Anna Dichtl, Heino Stöver, Hans Wolff
High levels of drug dependence have been observed in the prison population globally, and the sharing of injecting drug equipment in prisons has contributed to higher prevalence of bloodborne diseases in prisoners than in the general population. Few prison needle and syringe programs (PNSPs) exist. We conducted a systematic review to assess evidence regarding health outcomes of PNSPs. We searched peer-reviewed databases for data relating to needle and syringe programs in prisons. The search methodology was conducted in accordance with accepted guidelines...
April 12, 2018: Epidemiologic Reviews
https://www.readbyqxmd.com/read/29655395/firearm-related-injuries-among-canadian-children-and-youth-from-2006-to-2013-a-chirpp-study
#17
Catherine M J Cox, Samuel A Stewart, Katrina F Hurley
CLINICIAN'S CAPSULE What is known about the topic? Injuries from non-powder firearms are common and potentially life-altering. The Canadian Pediatric Society urges stricter controls on non-powder guns. What did this study ask? What are the Canadian contextual trends in paediatric firearm injuries? What did this study find? In this study, the rate of paediatric firearm injuries was stable from 2006 to 2013. Eye injuries inflicted by non-powder firearms were most common. Most firearm injuries occurred through recreation and sport...
April 15, 2018: CJEM
https://www.readbyqxmd.com/read/29650539/a-call-for-more-science-in-forensic-science
#18
Suzanne Bell, Sunita Sah, Thomas D Albright, S James Gates, M Bonner Denton, Arturo Casadevall
Forensic science is critical to the administration of justice. The discipline of forensic science is remarkably complex and includes methodologies ranging from DNA analysis to chemical composition to pattern recognition. Many forensic practices developed under the auspices of law enforcement and were vetted primarily by the legal system rather than being subjected to scientific scrutiny and empirical testing. Beginning in the 1990s, exonerations based on DNA-related methods revealed problems with some forensic disciplines, leading to calls for major reforms...
April 12, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29649616/subgenome-assignment-in-allopolyploids-challenges-and-future-directions
#19
REVIEW
Patrick P Edger, Michael R McKain, Kevin A Bird, Robert VanBuren
Whole genome duplications (WGDs), also known as polyploid events, have played a crucial role in the evolutionary success of angiosperms across recent and ancient timescales. A recurrent observation from the analysis of allopolyploids is that one of the parental subgenomes is generally more dominant, referred to as 'subgenome dominance', based on higher gene content and expression patterns. Subgenome dominance has far reaching implications to research areas ranging from crop improvement efforts to evolutionary and ecological studies...
April 9, 2018: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/29644436/the-neural-effects-of-positively-and-negatively-re-experiencing-mental-fatigue-sensation-a-magnetoencephalography-study
#20
Akira Ishii, Takuya Ishizuka, Yuki Muta, Masaaki Tanaka, Emi Yamano, Yasuyoshi Watanabe
Fatigue sensation is an essential biological alarm that urges us to take rest to avoid disrupting homeostasis and thus plays an important role in maintaining well-being. However, there are situations in which the anticipation of unpleasant fatigue sensation undesirably reduces motivation for activity. The aim of this study was to examine whether thinking positively about the fatigue sensation would increase motivation to accomplish the workload. Fourteen healthy male volunteers participated in this study and performed a two-back test for 30 min to induce mental fatigue sensation...
April 11, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
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