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Judith Elisabeth Müller, Nicole Meyer, Clarisa Guillermina Santamaria, Anne Schumacher, Enrique Hugo Luque, Maria Laura Zenclussen, Horacio Adolfo Rodriguez, Ana Claudia Zenclussen
Endocrine disrupting chemicals are long suspected to impair reproductive health. Bisphenol A (BPA) has estrogenic activity and therefore the capacity of interfering with endocrine pathways. No studies dissected its short-term effects on pregnancy and possible underlying mechanisms. Here, we studied how BPA exposure around implantation affects pregnancy, particularly concentrating on placentation and uterine remodeling. We exposed pregnant female mice to 50 µg/kg BPA/day or 0.1% ethanol by oral gavage from day 1 to 7 of gestation...
June 15, 2018: Scientific Reports
Shona Kalkman, Ghislaine J M W van Thiel, Diederick E Grobbee, Johannes J M van Delden
Pragmatic clinical trials generate robust real-world evidence that holds great potential to better inform decision making regarding new medicines. For clinicians, patients and regulators, this evidence would preferably be available sooner rather than later. This means that, ideally, market authorization of any given medicine is accompanied by evidence obtained from a pragmatic trial. Given the operational and regulatory complexities of pragmatic trials in general, stakeholders tend to be hesitant to employ more pragmatism at the time of market approval...
June 12, 2018: Drug Discovery Today
Rui Zhang, Sun Li, Xiao-Kai Zhang, Yu Wang, Liu-Yang Yang, Hao Zeng, Da-Peng Yan, Quan-Ming Zou, Qian-Fei Zuo
Increasing rates of life-threatening infections and decreasing susceptibility to antibiotics urge an effective vaccine targeting Staphylococcus aureus. Here we investigate the role of cellular immunity in FnBPA110-263 mediated protection in Staphylococcus aureus infection. This study revealed FnBPA110-263 broadly protected mice from seven FnBPA isotypes strains in the sepsis model. FnBPA110-263 immunized B-cell deficient mice were protected against lethal challenge, while T-cell deficient mice were not. Reconstituting mice with FnBPA110-263 specific CD4+ T-cells conferred antigen specific protection...
June 12, 2018: Clinical Immunology: the Official Journal of the Clinical Immunology Society
Himanshu Suri, Carrie Dougherty
PURPOSE OF REVIEW: This article provides an overview of headache in the setting of pituitary adenoma. The purpose of this article is to educate providers on the association, possible pathophysiology, and the clinical presentation of headache in pituitary tumor. RECENT FINDINGS: Recent prospective evaluations indicate that risk factors for development of headache in the setting of pituitary adenoma include highly proliferative tumors, cavernous sinus invasion, and personal or family history of headache...
June 15, 2018: Current Pain and Headache Reports
Allen M Chen, Taeko Yoshizaki, Pin-Chieh Wang, Darlene Veruttipong, Phillip J Beron, Robert Chin, Argin G Mikaeilian, Minsong Cao
Purpose: The practice of deliberately sparing the ipsilateral parotid gland with intensity modulated radiation therapy (IMRT) in patients with node-positive head and neck cancer is controversial. We sought to compare the clinical outcomes among consecutive cohorts of patients with head and neck cancer who were treated with differing strategies to spare the parotid gland that is ipsilateral to the involved neck using IMRT. Methods and materials: A total of 305 patients were treated with IMRT for node-positive squamous cell carcinoma of the head and neck...
April 2018: Advances in Radiation Oncology
Tejas M Dhameliya, Rishu Tiwari, Arkaprabha Banerjee, Sahaj Pancholia, Dharmarajan Sriram, Dulal Panda, Asit K Chakraborti
Tuberculosis is the second leading cause of deaths worldwide. The inadequacy of existing drugs to treat TB due to developed resistance and TB-HIV synergism urges for new anti-TB drugs. Seventy-two benzo[d]thiazole-2-carbanilides have been synthesized through CDI-mediated direct coupling of benzo[d]thiazole-2-carboxylic acids with aromatic amines using a three step methodology which includes a green protocol for synthesis of ethyl benzo[d]thiazole-2-carboxylates, precursor of the desired carboxylic acids. The compounds were evaluated in vitro for anti-tubercular activity against M...
June 8, 2018: European Journal of Medicinal Chemistry
Nan-Yao Su, Barry Yokum, Aaron Mullins, Ed Bordes, Carrie Cottone, Claudia Riegel
Fluid baits comprised of 10% dry medium (impregnated with 0.5% hexaflumuron) and 90% methylcel solution were injected into foraging galleries of the Formosan subterranean termite, Coptotermes formosanus Shiraki (Blattodea: Rhinotermitidae), in trees and buildings. Elimination times at two of the six baited sites were longer than expected, possibly due to the application disturbance or the presence of an old and declining colony, but fluid bait treatments eliminated all baited colonies. Fluid baits were injected through drill holes behind infested wood surface, and bypassed the difficulties for installing above-ground (AG) bait stations on uneven surface or at tight corners...
June 13, 2018: Journal of Economic Entomology
Junming Chen, Yongmei Xia, Xiaochen Sui, Qingrui Peng, Tongtong Zhang, Jian Li, Jue Zhang
New anticancer agents with lower toxicity have been always urged because of drug resistance associated with overused chemotherapy agents. In this study, steviol, a colonic metabolite of natural sweetener and also a component in leaves of stevia rebaudiana bertoni , was found to possess intensive anticancer activity on the human gastrointestinal cancer cells. Steviol inhibited six human gastrointestinal cancer cells intensively as 5-fluorouracil did at 100 μg/mL. The inhibition mechanism follows mitochondrial apoptotic pathway that was evidenced by increase of Bax/Bcl-2 ratio, activation of p21 and p53; and caspase 3-independent mechanism was also involved...
May 29, 2018: Oncotarget
Anna Janssen, Tracy Robinson, Melissa Brunner, Paul Harnett, Kylie E Museth, Tim Shaw
BACKGROUND: Multidisciplinary teams (MDTs) are an integral component in the delivery of health care. This is particularly evident in the delivery of cancer care, where multidisciplinary teams are internationally recognized as the preferred method for service delivery. The use of health information systems and technology are key enabling factors for building the capacity of MDTs to engage in improvement and implementation projects but there is scant research on how MDTs make use of technology and information systems or the kinds of systems needed for them to undertake improvement and implementation research...
June 13, 2018: BMC Health Services Research
Vasileios-Arsenios Lioutas, Sarah Marchina, Louis R Caplan, Magdy Selim, Joseph Tarsia, Luciana Catanese, Jonathan Edlow, Sandeep Kumar
BACKGROUND: Many patients with acute intracerebral hemorrhages (ICHs) undergo endotracheal intubation with subsequent mechanical ventilation (MV) for "airway protection" with the intent to prevent aspiration, pneumonias, and its related mortality. Conversely, these procedures may independently promote pneumonia, laryngeal trauma, dysphagia, and adversely affect patient outcomes. The net benefit of intubation and MV in this patient cohort has not been systematically investigated...
June 13, 2018: Cerebrovascular Diseases
Daniel Bello-Gil, Emma Roig-Molina, Jennifer Fonseca, María Dolores Sarmiento-Ferrández, Marcela Ferrándiz, Esther Franco, Elena Mira, Beatriz Maestro, Jesús M Sanz
The presence of synthetic dyes in wastewaters generated by the textile industry constitutes a serious environmental and health problem that urges the scientific community on an appropriate action. As a proof-of-concept, we have developed a novel approach to design enzymatic bioreactors with the ability to decolorize dye solutions through the immobilization of the bacterial CueO laccase-like multicopper oxidase from Escherichia coli on polyhydroxybutyrate (PHB) beads by making use of the BioF affinity tag. The decolorization efficiency of the system was characterized by a series of parameters, namely maximum enzyme adsorption capacity, pH profile, kinetic constants, substrate range, temperature and bioreactor recycling...
June 12, 2018: Microbial Biotechnology
Waleed Alharbi, Jennifer Cleland, Zoe Morrison
Objectives: We sought to evaluate patient safety culture across different healthcare professionals from different countries of origin working in an adult oncology department in a medical facility in Saudi Arabia. Methods: This cross-sectional survey of 130 healthcare staff (doctors, pharmacists, nurses) was conducted in February 2017. We used the Hospital Survey of Patient Safety Culture (HSOPSC) to examine healthcare staff perceptions of safety culture. Results: A total of 127 questionnaires were returned, yielding a response rate of 97...
May 2018: Oman Medical Journal
Julien Troudet, Régine Vignes-Lebbe, Philippe Grandcolas, Frédéric Legendre
Primary biodiversity data represent the fundamental elements of any study in systematics and evolution. They are, however, no longer gathered as they used to be and the mass-production of observation-based occurrences is overthrowing the collection of specimen-based occurrences. Although this change in practice is a major upheaval with significant consequences in the study of biodiversity, it remains understudied and has not attracted yet the attention it deserves. Analyzing 536 million occurrences from the Global Biodiversity Information Facility (GBIF) mediated data, we show that this spectacular change affects the 24 eukaryote taxonomic classes we targeted: from 1970 to 2016 the proportion of occurrences marked as traceable to tangible material (i...
June 8, 2018: Systematic Biology
Paweł W Petryszyn, Leszek Paradowski
BACKGROUND: Crohn's disease (CD) and ulcerative colitis (UC) typically clinically manifest with symptoms like chronic diarrhea, cramps, abdominal pain, and rectal bleeding. However, symptoms of abnormal anorectal function seem to be of equal importance, regardless of the presence or absence of perianal disease. OBJECTIVES: The aim of this study was to assess stool patterns and the prevalence of symptoms of disordered anorectal function, particularly urgency and fecal incontinence, and their severity in patients with inflammatory bowel diseases (IBDs)...
June 12, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Y Poorun, M Z Dauhoo, M Bessafi, M K Elahee, A Gopaul, A Khoodaruth
This work presents the development and physical analysis of a sweat transport model that couples the fluctuations in air and vapour concentrations, and temperature, in a one-dimensional porous clothing assembly. The clothing is exposed to inherent time-varying conditions due to variations in the body temperature and ambient conditions. These fluctuations are governed by a coupled system of nonlinear relaxation-transport-diffusion PDEs of Petrovskii parabolic type. A condition for the well-posedness of the resulting system of equations is derived...
May 2018: Royal Society Open Science
Leonard Dewaele, Olivier Lambert, Stephen Louwye
Historically, Monotherium had been one of the few genera of extinct Phocidae (true seals) that served as a wastebin taxon. Consequently, it did neither aid in understanding phylogenetic relationships of extinct Phocidae, nor in understanding seal diversity in deep time. This urged the reassessment of the genus. Before our review, Monotherium included five different species: Monotherium aberratum , Monotherium affine , and Monotherium delognii from Belgium; Monotherium gaudini from Italy; and Monotherium ? wymani from the east coast USA...
May 2018: Royal Society Open Science
Jonathan J Aning, Kenneth R MacKenzie, Michael Fabricius, Elaine McColl, Mark I Johnson, Zafer Tandogdu, Naeem A Soomro, Christopher Harding
OBJECTIVE: To prospectively evaluate short- to medium-term patient-reported lower urinary tract symptoms (LUTS) and their effect on health-related quality of life (HRQoL) using validated questionnaires in a large cohort of patients following robotic-assisted radical prostatectomy (RARP) for prostate cancer. MATERIALS AND METHODS: HRQoL and LUTS outcomes were prospectively assessed in 357 consecutive men undergoing RARP at a single center from 2012 to 2015 using the functional assessment of cancer therapy-prostate (FACT-P) and the international consultation on incontinence modular questionnaire-male LUTS (ICIQ-MLUTS)...
June 9, 2018: Urologic Oncology
Caroline Allen, Christian M Carrico, Samantha L Gomez, Peter C Andersen, Andrew A Turnipseed, Craig J Williford, John W Birks, Dwayne Salisbury, Richard Carrion, Dan Gates, Fabian Macias, Thom Rahn, Allison C Aiken, Manvendra K Dubey
Understanding nitrogen oxides (NOx  = NO + NO2 ) measurement techniques is important as air-quality standards become more stringent, important sources change, and instrumentation develops. NOx observations are compared in two environments: source testing from the combustion of southwestern biomass fuels and urban, ambient NOx . The latter occurred in the urban core of Albuquerque, NM at an EPA NCORE site during February-March 2017, a relatively clean photochemical environment with ozone (O3 ) < 60 ppb for all but 6 hours...
June 11, 2018: Journal of the Air & Waste Management Association
Christy L M Hui, Whitty W T Leung, Andreas K H Wong, Ka Yan Loong, Joy Kok, Amanda Hwang, Edwin H M Lee, Sherry K W Chan, Wing Chung Chang, Eric Y H Chen
AIM: Although the reasons behind the stigmatization of psychosis are manifold, poor mental health literacy among the general public is likely to be a major factor. In Hong Kong, the Early Psychosis Foundation (EPISO) was established in 2007 to tackle this issue by providing educational and mental health promotional activities, among other aims and services. The current study evaluated the effectiveness of a school-based interventional programme, the School Tour, developed by EPISO. METHODS: The School Tour differentiates itself from other interventional programmes by supplementing a traditional psychoeducational talk with 2 additional elements: an engaging drama performance and exercise demonstrations...
June 11, 2018: Early Intervention in Psychiatry
Attila W Kovács, Viktor R Tóth, Károly Pálffy
Eutrophication and enhanced external nutrient loading of lakes and seas are most clearly reflected by increased cyanobacterial blooms, which are often toxic. Freshwater cyanobacteria produce a number of bioactive secondary metabolites, some of which have allelopathic properties, significantly influencing the biological processes of other algae, thereby affecting species composition and succession of the phytoplankton. The goal of this work was to investigate the influence of bloom-forming cyanobacterial exudates on the photophysiology of the green alga Scenedesmus quadricauda by chlorophyll fluorescence analysis...
June 2018: Acta Biologica Hungarica
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