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https://www.readbyqxmd.com/read/28335491/health-and-wellbeing-of-occupants-in-highly-energy-efficient-buildings-a-field-study
#1
Peter Wallner, Peter Tappler, Ute Munoz, Bernhard Damberger, Anna Wanka, Michael Kundi, Hans-Peter Hutter
Passive houses and other highly energy-efficient buildings need mechanical ventilation. However, ventilation systems in such houses are regarded with a certain degree of skepticism by parts of the public due to alleged negative health effects. Within a quasi-experimental field study, we investigated if occupants of two types of buildings (mechanical vs. natural ventilation) experience different health, wellbeing and housing satisfaction outcomes and if associations with indoor air quality exist. We investigated 123 modern homes (test group: with mechanical ventilation; control group: naturally ventilated) built in the years 2010 to 2012 in the same geographic area and price range...
March 19, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28335439/mercury-levels-in-human-hair-and-farmed-fish-near-artisanal-and-small-scale-gold-mining-communities-in-the-madre-de-dios-river-basin-peru
#2
Aubrey L Langeland, Rebecca D Hardin, Richard L Neitzel
Artisanal and small-scale gold mining (ASGM) has been an important source of income for communities in the Madre de Dios River Basin in Peru for hundreds of years. However, in recent decades, the scale of ASGM activities in the region has increased dramatically, and exposures to a variety of occupational and environmental hazards related to ASGM, including mercury, are becoming more widespread. The aims of our study were to: (1) examine patterns in the total hair mercury level of human participants in several communities in the region and compare these results to the 2...
March 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28335091/assessment-of-genetic-diversity-and-phylogenetic-relationships-of-korean-native-chicken-breeds-using-microsatellite-markers
#3
Joo Hee Seo, Jun-Heon Lee, Hong Sik Kong
In this study, the genetic diversity and phylogenetic relationships of 445 Korean native chickens from five different breeds(Korean Native Chicken (NC), Leghorn (LH), Cornish (CS), Rhode Island Red (RIR), and Hanhyup(HH) commercial line) were studied by performing genotyping using 20 microsatellite (MS) markers. Among the 20 MS markers selected for the genotyping, the number of alleles ranged from 5 (ADL0268) to 20 (MCW0127). The observed heterozygosity (Hobs) ranged from 0.349 (GCT0016) to 0.683 (MCW0145)...
March 21, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28334978/therapeutic-window-of-dopamine-d2-3-receptor-occupancy-to-treat-psychosis-in-alzheimer-s-disease
#4
Suzanne Reeves, Emma McLachlan, Julie Bertrand, Fabrizia D Antonio, Stuart Brownings, Akshay Nair, Suki Greaves, Alan Smith, David Taylor, Joel Dunn, Paul Marsden, Robert Kessler, Robert Howard
Antipsychotic drugs, originally developed to treat schizophrenia, are used to treat psychosis, agitation and aggression in Alzheimer's disease. In the absence of dopamine D2/3 receptor occupancy data to inform antipsychotic prescribing for psychosis in Alzheimer's disease, the mechanisms underpinning antipsychotic efficacy and side effects are poorly understood. This study used a population approach to investigate the relationship between amisulpride blood concentration and central D2/3 occupancy in older people with Alzheimer's disease by combining: (i) pharmacokinetic data (280 venous samples) from a phase I single (50 mg) dose study in healthy older people (n = 20, 65-79 years); (ii) pharmacokinetic, 18F-fallypride D2/3 receptor imaging and clinical outcome data on patients with Alzheimer's disease who were prescribed amisulpride (25-75 mg daily) to treat psychosis as part of an open study (n = 28; 69-92 years; 41 blood samples, five pretreatment scans, 19 post-treatment scans); and (iii) 18F-fallypride imaging of an antipsychotic free Alzheimer's disease control group (n = 10, 78-92 years), to provide additional pretreatment data...
February 4, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28334477/latent-classes-of-alcohol-problems-in-mauritian-men-results-from-the-joint-child-health-project
#5
Susan E Luczak, Carol A Prescott, Peter H Venables
INTRODUCTION AND AIMS: The purpose of this study was to identify latent classes of alcohol problems and their sociodemographic correlates in the east African nation of Mauritius. DESIGN AND METHODS: Participants were from the Joint Child Health Project, a longitudinal study of a 1969-1970 birth cohort of 1795 individuals. In mid-adulthood (M = 37 years), all available participants (n = 1206; 67% of the original cohort) were assessed for demographic characteristics, and lifetime drinkers were assessed for alcohol-related problems...
March 23, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28334406/male-and-female-cervical-spine-biomechanics-and-anatomy-implication-for-scaling-injury-criteria
#6
Narayan Yoganandan, Cameron R Bass, Liming Voo, Frank A Pintar
There is an increased need to develop female-specific injury criteria and anthropomorphic test devices (dummies) for automotive and military environments, especially as women take occupational roles traditionally reserved for men. Although some exhaustive reviews on the biomechanics and injuries of the human spine have appeared in clinical and bioengineering literatures, focus on the difference between male and female cervical spine responses and characteristics has largely been ignored. Current neck injury criteria for automotive dummies for assessing crashworthiness and occupant safety are obtained from animal and human cadaver experiments, computational modeling and human volunteer studies...
March 23, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28334313/colour-vision-requirements-in-visually-demanding-occupations
#7
J L Barbur, M Rodriguez-Carmona
Normal trichromatic colour vision (CV) is often required as a condition for employment in visually demanding occupations. If this requirement could be enforced using current, colour assessment tests, a significant percentage of subjects with anomalous, congenital trichromacy who can perform the suprathreshold, colour-related tasks encountered in many occupations with the same accuracy as normal trichromats would fail. These applicants would therefore be discriminated against unfairly. One solution to this problem is to produce minimum, justifiable CV requirements that are specific to each occupation...
March 18, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28334005/multi-scale-model-of-drug-induced-adaptive-resistance-of-gram-negative-bacteria-to-polymyxin-b
#8
Wojciech Krzyzanski, Gauri G Rao
The purpose of this report is to apply multi-scale modeling using the theory of physiologically structured populations (PSP) to develop a mathematical model for antimicrobial resistance based on a heterogeneous distribution of receptors and affinities among bacterial cells. The theory has been tested on data obtained from an in vitro static time-kill infection model analyzing the pharmacodynamics of polymyxin B against Gram-negative bacteria. The drug binding parameter KD (dissociation equilibrium constant) is assumed to vary between the bacterial cells...
2017: PloS One
https://www.readbyqxmd.com/read/28333987/genome-scale-identification-of-nucleosome-organization-by-using-1000-porcine-oocytes-at-different-developmental-stages
#9
Chenyu Tao, Juan Li, Baobao Chen, Daming Chi, Yaqiong Zeng, Honglin Liu
The nucleosome is the basic structural unit of chromosomes, and its occupancy and distribution in promoters are crucial for the regulation of gene expression. During the growth process of porcine oocytes, the "growing" oocytes (SF) have a much higher transcriptional activity than the "fully grown" oocytes (BF). However, the chromosome status of the two kinds of oocytes remains poorly understood. In this study, we profiled the nucleosome distributions of SF and BF with as few as 1000 oocytes. By comparing the altered regions, we found that SF tended toward nucleosome loss and more open chromosome architecture than BF did...
2017: PloS One
https://www.readbyqxmd.com/read/28333497/not-all-nonnormal-distributions-are-created-equal-improved-theoretical-and-measurement-precision
#10
Harry Joo, Herman Aguinis, Kyle J Bradley
We offer a four-category taxonomy of individual output distributions (i.e., distributions of cumulative results): (1) pure power law; (2) lognormal; (3) exponential tail (including exponential and power law with an exponential cutoff); and (4) symmetric or potentially symmetric (including normal, Poisson, and Weibull). The four categories are uniquely associated with mutually exclusive generative mechanisms: self-organized criticality, proportionate differentiation, incremental differentiation, and homogenization...
March 23, 2017: Journal of Applied Psychology
https://www.readbyqxmd.com/read/28333489/occupations-and-the-prevalence-of-major-depressive-episode-in-the-national-survey-on-drug-use-and-health
#11
Albert Woodward, Rachel Lipari, William Eaton
OBJECTIVE: This study explores the relationship of occupations to major depressive episode (MDE). METHOD: National Survey on Drug Use and Health (NSDUH) data from the civilian noninstitutionalized United States population are analyzed regarding mental illnesses, employment, and specific occupations and industries. This analysis uses combined 2005 to 2014 NSDUH data, comprising a sample of 433,000 adults aged 18 to 64 years old, of whom 22,700 were both employed and had experienced an MDE in the past year...
March 23, 2017: Psychiatric Rehabilitation Journal
https://www.readbyqxmd.com/read/28332953/patterns-of-response-by-sociodemographic-characteristics-and-recruitment-methods-for-women-in-uk-population-surveys-and-cohort-studies
#12
Sarah J Howcutt, Anna L Barnett, Sofia Barbosa Boucas, Lesley A Smith
Women are an important public health focus, because they are more likely to experience some social determinants of disease, and they influence family health. Little research has explored the sociodemographic representativeness of women in research studies. We examined the representativeness of female respondents across four sociodemographic factors in UK population surveys and cohort studies. Six UK population-based health surveys (from 2009-2013) and eight Medical Research Council cohort studies (from 1991 to 2014) were included...
March 23, 2017: Women & Health
https://www.readbyqxmd.com/read/28332863/male-and-female-worldsid-and-post-mortem-human-subject-responses-in-full-scale-vehicle-tests
#13
Narayan Yoganandan, John Humm, Frank Pintar, Heather Rhule, Kevin Moorhouse, Brian Suntay, Jim Stricklin, Rodney Rudd, Matthew Craig
Structured ABSTRACT Objective: To compare the responses of male and female WorldSID dummies with post mortem human subject (PMHS) responses in full-scale vehicle tests. METHODS: Tests were conducted according to the FMVSS-214 protocols and using the United States Side impact New Car Assessment Program change in velocity to match PMHS experiments, published earlier. Moving deformable barrier (MDB) tests were conducted with the male and female surrogates in the left front and left rear seats...
March 23, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28332855/occupant-to-occupant-contact-injury-in-motor-vehicle-crashes
#14
David C Viano, Chantal S Parenteau
OBJECTIVE: This is a descriptive study of the frequency and risk of occupant-to-occupant contact injury by crash type and occupant age. It focused on rear impacts because of a recent Senate inquiry. METHODS: 1994-2013 NASS-CDS data was used to investigate the effects of occupant-to-occupant contact on the risk of serious-to-fatal injury (AIS 3+) by crash type and age group. NASS-CDS in-depth cases were analyzed to identify crash circumstances for AIS 3+ occupant-to-occupant contact injury in rear crashes...
March 23, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28332562/new-insights-on-the-biomineralisation-process-developing-in-human-lungs-around-inhaled-asbestos-fibres
#15
Fabrizio Bardelli, Giulia Veronesi, Silvana Capella, Donata Bellis, Laurent Charlet, Alessia Cedola, Elena Belluso
Once penetrated into the lungs of exposed people, asbestos induces an in vivo biomineralisation process that leads to the formation of a ferruginous coating embedding the fibres. The ensemble of the fibre and the coating is referred to as asbestos body and is believed to be responsible for the high toxicological outcome of asbestos. Lung tissue of two individuals subjected to prolonged occupational exposure to crocidolite asbestos was investigated using synchrotron radiation micro-probe tools. The distribution of K and of elements heavier than Fe (Zn, Cu, As, and Ba) in the asbestos bodies was observed for the first time...
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28332418/asthma-status-is-an-independent-risk-factor-for-herpes-zoster-in-children-a-population-based-cohort-study
#16
Su-Jing Chen, Kuang-Hua Huang, Wen-Chen Tsai, Cheng-Li Lin, Yih-Dih Cheng, Chang-Ching Wei
The literature regarding the effects of childhood asthma on the risk of herpes zoster (HZ) is very limited. The aim of this study is to investigate the risks of children developing HZ with asthma. From the National Health Insurance Research Database, a total of 600,891 children were enrolled in this study between 2000 and 2007. The children were matched by age, gender, level of urbanization, and parental occupation. All subjects were followed until the end of 2008. A Cox model was used to estimate the association of asthma on the risk of HZ...
March 23, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/28332206/contract-care-in-dentistry-sense-making-of-the-concept-and-in-practice-when-multiple-institutional-logics-are-at-play
#17
Ylva Ulfsdotter Eriksson, Karin Berg, Ulla Wide Boman, Magnus Hakeberg
In 2009 contract dental care was introduced into Sweden's Public Dental Service under a programme called Dental Care for Health (DCH). Previous research has revealed a possible dilemma whereby dental care professionals had the role of insurance agent foisted upon them, as they were assigned the task of 'selling contracts'. Using qualitative interviews, this study explores how these professionals make sense of contract dental care today. Drawing on the concepts of occupational and organisational professionalism, in combination with the institutional logics perspective, we discern that dental care professionals are entangled in multiple rationalities when reasoning about and dealing with DCH...
March 23, 2017: Sociology of Health & Illness
https://www.readbyqxmd.com/read/28332072/are-the-autoimmune-inflammatory-syndrome-induced-by-adjuvants-asia-and-the-undifferentiated-connective-tissue-disease-uctd-related-to-each-other-a-case-control-study-of-environmental-exposures
#18
F Scanzi, L Andreoli, M Martinelli, M Taraborelli, I Cavazzana, N Carabellese, R Ottaviani, F Allegri, F Franceschini, N Agmon-Levin, Y Shoenfeld, Angela Tincani
The autoimmune/inflammatory syndrome induced by adjuvants (ASIA) is an entity that includes different autoimmune conditions observed after exposure to an adjuvant. Patients with undifferentiated connective tissue disease (UCTD) present many signs and symptoms of ASIA, alluding to the idea that an exposure to adjuvants can be a trigger also for UCTD. The aim of this case-control study was to investigate exposure to adjuvants prior to disease onset in patients affected by UCTD. Ninety-two UCTD patients and 92 age- and sex-matched controls with no malignancy, chronic infections, autoimmune disease nor family history of autoimmune diseases were investigated for exposure to adjuvants...
March 22, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28331627/topical-drug-induced-subacute-cutaneous-lupus-erythematosus-isolated-to-the-hands
#19
Sarika M Ramachandran, Jonathan S Leventhal, Loren G Franco, Adnan Mir, Ruth F Walters, Andrew G Franks
Subacute cutaneous lupus erythematosus (SCLE) is a well-defined subtype of lupus erythematosus, characterised by photosensitivity, annular and/or psoriasiform lesions, variable systemic involvement and presence of circulating SSA/anti-Ro antibodies. SCLE may be idiopathic or drug-induced. Both the idiopathic and drug-induced forms of SCLE are analogous in their clinical, serological and histological features. Drug-induced SCLE has been reported with various oral agents, but to our knowledge this is the first reported case due to a topical medication...
2017: Lupus Science & Medicine
https://www.readbyqxmd.com/read/28331534/ford-and-edison-in-a-modern-regulatory-environment-the-first-in-human-trial-of-night-work-and-artificial-light
#20
EDITORIAL
Thomas C Erren, David M Shaw, Ursula Wild, J Valérie Groß
A thought experiment places Henry Ford and Thomas Alva Edison in a modern regulatory environment. In a utopian occupational world devoid of night-shifts or artificial light, Ford wants to experiment with "working through the night". To support Ford's project, Edison offers his patented electric lamps to "turn nights into days". An ethics committee [EC] does not approve the night-work experiment and Utopia's Food and Drug Administration [FDA] does not approve the potential medical device as safe for use by humans...
2017: Journal of Occupational Medicine and Toxicology
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