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Pediatric ibuprofen

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https://www.readbyqxmd.com/read/27899166/pain-management-of-acute-appendicitis-in-canadian-pediatric-emergency-departments
#1
Andrea L Robb, Samina Ali, Naveen Poonai, Graham C Thompson
OBJECTIVES: Children with suspected appendicitis are at risk for suboptimal pain management. We sought to describe pain management patterns for suspected appendicitis across Canadian pediatric emergency departments (PEDs). METHODS: A retrospective medical record review was undertaken at 12 Canadian PEDs. Children ages 3 to 17 years who were admitted to the hospital in February or October 2010 with suspected appendicitis were included. Patients were excluded if partially assessed or treated at another hospital...
November 30, 2016: CJEM
https://www.readbyqxmd.com/read/27872357/antipyretic-efficacy-and-safety-of-ibuprofen-versus-acetaminophen-suspension-in-febrile-children-results-of-2-randomized-double-blind-single-dose-studies
#2
Shyamalie Jayawardena, David Kellstein
Two blinded single-dose studies randomized children 6 months to 11 years old with fever to receive ibuprofen (IBU) pediatric suspension 7.5 mg/kg or acetaminophen (APAP) suspension 10 to 15 mg/kg. The primary efficacy parameter was time-weighted sum of temperature differences (TWSTD) from baseline through 8 hours for each study. Secondary end points included TWSTD from baseline through 6 hours, time to onset and duration of temperature control, and proportion with temperature control. Studies were pooled for post hoc analyses of efficacy and adverse event end points...
November 20, 2016: Clinical Pediatrics
https://www.readbyqxmd.com/read/27810155/2016-update-of-the-italian-pediatric-society-guidelines-for-management-of-fever-in-children
#3
Elena Chiappini, Elisabetta Venturini, Giulia Remaschi, Nicola Principi, Riccardo Longhi, Pier-Angelo Tovo, Paolo Becherucci, Francesca Bonsignori, Susanna Esposito, Filippo Festini, Luisa Galli, Bice Lucchesi, Alessandro Mugelli, Gian Luigi Marseglia, Maurizio de Martino
OBJECTIVE: To review new scientific evidence to update the Italian guidelines for managing fever in children as drafted by the panel of the Italian Pediatric Society. STUDY DESIGN: Relevant publications in English and Italian were identified through search of MEDLINE and the Cochrane Database of Systematic Reviews from May 2012 to November 2015. RESULTS: Previous recommendations are substantially reaffirmed. Antipyretics should be administered with the purpose to control the child's discomfort...
October 31, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27794128/association-of-acetaminophen-and-ibuprofen-use-with-wheezing-in-children-with-acute-febrile-illness
#4
Ilan Matok, Arnon Elizur, Amichai Perlman, Shani Ganor, Hagai Levine, Eran Kozer
BACKGROUND: Many infants and children receive acetaminophen and/or ibuprofen during febrile illness. Previously, some studies have linked acetaminophen and ibuprofen use to wheezing and exacerbation of asthma symptoms in infants and children. OBJECTIVE: To assess whether acetaminophen or ibuprofen use are associated with wheezing in children presenting to the emergency department (ED) with febrile illness. METHODS: This was a cross-sectional study of children who presented with fever to the pediatric ED between 2009 and 2013...
October 27, 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/27751698/does-the-use-of-ibuprofen-in-children-with-extremity-fractures-increase-their-risk-for-bone-healing-complications
#5
Kerrin C DePeter, Stephen M Blumberg, Sarah Dienstag Becker, James A Meltzer
BACKGROUND: Despite being an effective analgesic for children with fractures, some clinicians may avoid prescribing ibuprofen due to its potentially harmful effect on bone healing. OBJECTIVE: To determine if exposure to ibuprofen is associated with an increased risk of bone healing complications in children with fractures. METHODS: We performed a retrospective study of children aged 6 months to 17 years who presented to the pediatric emergency department (PED) with a fracture of the tibia, femur, humerus, scaphoid, or fifth metatarsus and who followed up with the orthopedic service...
October 14, 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27600629/primary-caregiver-perception-of-pain-control-following-pediatric-adenotonsillectomy-a-cross-sectional-survey
#6
Justin C Sowder, Craig M Gale, Jacob L Henrichsen, Kristy Veale, Katie B Liljestrand, Barbara C Ostlund, Aaron Sherwood, Austin Smith, Griffin H Olsen, Mark Ott, Jeremy D Meier
OBJECTIVES: To (1) review pain medications prescribed following pediatric adenotonsillectomy (T&A), (2) identify pain medications reported to be helpful, and (3) compare parent-reported outcomes among various combinations of pain medications. STUDY DESIGN: Case series with planned data collection. SETTING: Multihospital network. SUBJECTS AND METHODS: The primary caregivers of children aged 1 to 18 years who underwent isolated T&A from June to December 2014 were contacted 14 to 21 days after surgery...
September 6, 2016: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/27580638/continuous-infusion-nonsteroidal-anti-inflammatory-drugs-for-perioperative-pain-management
#7
Meredith L Howard, Alex N Isaacs, Sarah A Nisly
PURPOSE: To review the use of continuous infusion (CI) nonsteroidal anti-inflammatory drugs (NSAIDs) as an alternative modality for pain control in surgical patient populations. METHODS: A PubMed and MEDLINE search was conducted from 1964 through February 2016 using the following search terms alone or in combinations: continuous, infusion, nonsteroidal anti-inflammatory drug, diclofenac, ibuprofen, indomethacin, ketoprofen, ketorolac, and surgery. All English-language, prospective and retrospective, adult and pediatric studies evaluating intravenous or intramuscular CI NSAIDs for surgical pain were evaluated for inclusion in this review...
August 31, 2016: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/27559255/specialist-pediatric-palliative-care-prescribing-practices-a-large-5-year-retrospective-audit
#8
Anuja Damani, Naveen Salins, Arunangshu Ghoshal, MaryAnn Muckaden
INTRODUCTION: There is a gradual increasing trend in childhood cancers in India and pediatric palliative care in India is an emerging specialty. Prescribing pain and symptom control drugs in children with cancer requires knowledge of palliative care formulary, dosing schedules, and prescription guidelines. This study is a retrospective audit of prescribing practices of a specialist palliative care service situated in a tertiary cancer center. METHODS: A total of 1135 medication records of children receiving specialist pediatric palliative care services were audited for 5 years (2010-2014) to evaluate prescribing practices in children with advanced cancer...
July 2016: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/27509008/trends-and-variation-in-management-and-outcomes-of-very-low-birth-weight-infants-with-patent-ductus-arteriosus
#9
James I Hagadorn, Elizabeth A Brownell, Jennifer M Trzaski, Kendall R Johnson, Shabnam Lainwala, Brendan T Campbell, Katherine W Herbst
BACKGROUND: We examined recent trends and interhospital variation in use of indomethacin, ibuprofen, and surgical ligation for patent ductus arteriosus (PDA) in very-low-birth-weight (VLBW) infants. METHODS: Included in this retrospective study of the Pediatric Hospital Information System database were 13,853 VLBW infants from 19 US children's hospitals, admitted at age < 3 d between 1 January 2005 and 31 December 2014. PDA management and in-hospital outcomes were examined for trends and variation...
December 2016: Pediatric Research
https://www.readbyqxmd.com/read/27503180/newly-approved-agents-for-the-treatment-and-prevention-of-pediatric-migraine
#10
REVIEW
Joanne Kacperski, Andrew D Hershey
Treatment of pediatric migraine remains an unmet medical need. There continues to be a paucity of pediatric randomized controlled trials for the treatment of migraine, both in the acute and preventive settings. Pediatric studies are often complicated by high placebo-response rates and much of our current practice is based on adult trials. This lack of significant pediatric studies results in a wide variation in migraine management both amongst clinicians and between institutions, and evidence-based treatments are not always administered...
September 2016: CNS Drugs
https://www.readbyqxmd.com/read/27461191/analgesia-for-acute-gingivostomatitis-a-national-survey-of-pediatric-emergency-physicians
#11
Joe MacLellan, Samina Ali, Sarah Curtis, Jason Baserman, Andrew Dixon
OBJECTIVES: Gingivostomatitis is a common, painful pediatric presentation, and yet, few studies are available to guide management. We aimed to describe pediatric emergency physicians' current practice patterns, with respect to analgesic use in children with acute gingivostomatitis, in order to inform future studies. METHODS: A national survey was conducted at all 15 national academic pediatric centres. Electronic surveys were distributed to pediatric emergency physicians using a modified Dillman protocol; non-respondents received paper surveys via post...
July 27, 2016: CJEM
https://www.readbyqxmd.com/read/27445614/pain-management-of-pediatric-musculoskeletal-injury-in-the-emergency-department-a-systematic-review
#12
REVIEW
Sylvie Le May, Samina Ali, Christelle Khadra, Amy L Drendel, Evelyne D Trottier, Serge Gouin, Naveen Poonai
Background. Pain management for children with musculoskeletal injuries is suboptimal and, in the absence of clear evidence-based guidelines, varies significantly. Objective. To systematically review the most effective pain management for children presenting to the emergency department with musculoskeletal injuries. Methods. Electronic databases were searched systematically for randomized controlled trials of pharmacological and nonpharmacological interventions for children aged 0-18 years, with musculoskeletal injury, in the emergency department...
2016: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/27356085/microarray-gene-expression-analysis-in-ovine-ductus-arteriosus-during-fetal-development-and-birth-transition
#13
Ravi Goyal, Dipali Goyal, Lawrence D Longo, Ronald I Clyman
BACKGROUND: Patent ductus arteriosus (PDA) in the newborn is the most common congenital heart anomaly and is significantly more common in preterm infants. Contemporary pharmacological treatment is effective in only 70-80% of the cases. Moreover, indomethacin or ibuprofen, which are used to close a PDA may be accompanied by serious side effects in premature infants. To explore the novel molecular pathways, which may be involved in the maturation and closure of the ductus arteriosus (DA), we used fetal and neonatal sheep to test the hypothesis that maturational development of DA is associated with significant alterations in specific mRNA expression...
October 2016: Pediatric Research
https://www.readbyqxmd.com/read/27355884/acute-agitation-and-self-injury-in-a-5-year-old-with-autism
#14
Jason Schweitzer, Christine James, Willough Jenkins, Michael I Reiff, Martin T Stein
A 5-year-old nonverbal child with autism spectrum disorder (ASD) was admitted to inpatient pediatrics with new onset agitation and self-injurious behavior. His parents described him as a pleasant child without previous episodes of self-injury. Four days before admission, the parents noted new irritability followed by 2 days of self-injury to the face without clear precipitant. His hitting intensified with closed fist to face, and he required parental physical restraint to prevent further injury. Car rides and ibuprofen provided only temporary relief...
September 2016: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/27317686/ibuprofen-regulation-of-microtubule-dynamics-in-cystic-fibrosis-epithelial-cells
#15
Sharon M Rymut, Claire M Kampman, Deborah A Corey, Tori Endres, Calvin U Cotton, Thomas J Kelley
High-dose ibuprofen, an effective anti-inflammatory therapy for the treatment of cystic fibrosis (CF), has been shown to preserve lung function in a pediatric population. Despite its efficacy, few patients receive ibuprofen treatment due to potential renal and gastrointestinal toxicity. The mechanism of ibuprofen efficacy is also unclear. We have previously demonstrated that CF microtubules are slower to reform after depolymerization compared with respective wild-type controls. Slower microtubule dynamics in CF cells are responsible for impaired intracellular transport and are related to inflammatory signaling...
August 1, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27260499/managing-pediatric-pain-in-the-emergency-department
#16
REVIEW
Benoit Bailey, Evelyne D Trottier
Far more attention is now given to pain management in children in the emergency department (ED). When a child arrives, pain must be recognized and evaluated using a pain scale that is appropriate to the child's development and regularly assessed to determine whether the pain intervention was effective. At triage, both analgesics and non-pharmacological strategies, such as distraction, immobilization, and dressing should be started. For mild pain, oral ibuprofen can be administered if the child has not received it at home, whereas ibuprofen and paracetamol are suitable for moderate pain...
August 2016: Paediatric Drugs
https://www.readbyqxmd.com/read/27255487/drug-safety-monitoring-in-children-performance-of-signal-detection-algorithms-and-impact-of-age-stratification
#17
Osemeke U Osokogu, Caitlin Dodd, Alexandra Pacurariu, Florentia Kaguelidou, Daniel Weibel, Miriam C J M Sturkenboom
INTRODUCTION: Spontaneous reports of suspected adverse drug reactions (ADRs) can be analyzed to yield additional drug safety evidence for the pediatric population. Signal detection algorithms (SDAs) are required for these analyses; however, the performance of SDAs in the pediatric population specifically is unknown. We tested the performance of two SDAs on pediatric data from the US FDA Adverse Event Reporting System (FAERS) and investigated the impact of age stratification and age adjustment on the performance of SDAs...
September 2016: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/27203165/-adverse-drug-reactions-in-pediatrics-experience-of-a-regional-pharmacovigilance-center
#18
Caroline Saint-Martin, Lukshe Kanagaratnam, Paul de Boissieu, Brahim Azzouz, Malak Abou Taam, Thierry Trenque
AIM: To describe the adverse drug reactions (ADR) and the drugs involved in pediatrics. METHODS: An observational study on all ADR notifications recorded in the French pharmacovigilance database by the Regional Pharmacovigilance Center of Champagne-Ardenne between 1 January 1985 and 31 December 2014 involving children from 0 to 17 years inclusive was performed. For all notifications, we studied the patient and the ADR characteristics. RESULTS: During the study period, 632 notifications were collected...
April 11, 2016: Thérapie
https://www.readbyqxmd.com/read/27188704/the-use-of-ibuprofen-in-posttonsillectomy-analgesia-and-its-effect-on-posttonsillectomy-hemorrhage-rate
#19
Julia A Pfaff, Kevin Hsu, Sri Kiran Chennupati
OBJECTIVE: To determine the effect of ibuprofen on posttonsillectomy bleeding when compared with codeine in posttonsillectomy analgesia. STUDY DESIGN: Case series with chart review. SETTING: Tertiary care children's hospital, Philadelphia, Pennsylvania. SUBJECTS AND METHODS: On July 1, 2012, our institution transitioned from acetaminophen with codeine to ibuprofen for posttonsillectomy analgesia. Pediatric patients (0-18 years old) who underwent surgery from July 1, 2010, to June 30, 2012, were placed in the codeine cohort, and those who underwent surgery from July 1, 2012, to June 30, 2014, were placed in the ibuprofen cohort...
September 2016: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/26925101/granisetron-versus-granisetron-dexamethasone-for-prevention-of-postoperative-nausea-and-vomiting-in-pediatric-strabismus-surgery-a-randomized-double-blind-trial
#20
Renu Sinha, Dilip Shende, Souvik Maitra, Neeraj Kumar, Bikash Ranjan Ray, Virender Kumar Mohan
Aim. Efficacy of granisetron and combination of granisetron and dexamethasone was evaluated for prevention of postoperative nausea and vomiting (PONV) in children undergoing elective strabismus surgery. Methods. A total of 136 children (1-15 years) were included. Children received either granisetron (40 mcg/kg) [group G] or combination of granisetron (40 mcg/kg) and dexamethasone (150 mcg/kg) [group GD]. Intraoperative fentanyl requirement and incidence and severity of oculocardiac reflex were assessed...
2016: Anesthesiology Research and Practice
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