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https://www.readbyqxmd.com/read/28102082/characterization-of-the-molecular-mechanisms-underlying-the-chronic-phase-of-stroke-in-a-cynomolgus-monkey-model-of-induced-cerebral-ischemia
#1
Henry C H Law, Samuel S W Szeto, Quan Quan, Yun Zhao, Zaijun Zhang, Olga Krakovska, Leong Ting Lui, Chengyou Zheng, Simon Ming Yuen Lee, K W Michael Siu, Yuqiang Wang, Ivan K Chu
Stroke is one of the main causes of mortality and long-term disability worldwide. The pathophysiological mechanisms underlying this disease are not well understood, particularly in the chronic phase after the initial ischemic episode. In this study, a Macaca fascicularis stroke model consisting of two sample groups, as determined by MRI-quantified infarct volumes as a measure of the stroke severity 28 days after the ischemic episode, was evaluated using qualitative and quantitative proteomics analyses. By using multiple online multidimensional liquid chromatography platforms, 8790 non-redundant proteins that condensed to 5223 protein groups at 1% global false discovery rate (FDR)...
January 19, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28098297/spontaneous-assembly-of-a-hybrid-crystal-liquid-phase-in-inverse-patchy-colloid-systems
#2
Silvano Ferrari, Emanuela Bianchi, Gerhard Kahl
Materials with well-defined architectures are heavily sought after in view of their diverse technological applications. Among the desired target architectures, lamellar phases stand out for their exceptional mechanical and optical features. Here we show that charged colloids, decorated on their poles with two oppositely charged regions possess the unusual ability to spontaneously assemble in different morphologies of (semi-)ordered, layered particle arrangements which maintain their structural stability over a surprisingly large temperature range...
January 18, 2017: Nanoscale
https://www.readbyqxmd.com/read/28098287/second-harmonic-phase-determination-by-real-time-in-situ-interferometry
#3
Bason Clancy, Joshua Salafsky
Second Harmonic Generation (SHG) has emerged as a highly sensitive probe of protein conformation. SHG can also be used to determine the tilt angle of an SHG-active moiety bound to a surface-adsorbed protein through polarization-dependent measurements. However, due to the coherent nature of SHG, interference occurs between the SHG produced by the SHG-active moieties and background sources at a solid-liquid interface, obscuring the signal of interest. In order to separate the protein-specific signal from the background signal, the phase difference between these two different sources of SHG must be determined...
January 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28098209/crystal-growth-of-dirac-semimetal-zrsis-with-high-magnetoresistance-and-mobility
#4
Raman Sankar, G Peramaiyan, I Panneer Muthuselvam, Christopher J Butler, Klauss Dimitri, Madhab Neupane, G Narsinga Rao, M-T Lin, F C Chou
High quality single crystal ZrSiS as a theoretically predicted Dirac semimetal has been grown successfully using a vapor phase transport method. The single crystals of tetragonal structure are easy to cleave into perfect square-shaped pieces due to the van der Waals bonding between the sulfur atoms of the quintuple layers. Physical property measurement results including resistivity, Hall coefficient (RH), and specific heat are reported. The transport and thermodynamic properties suggest a Fermi liquid behavior with two Fermi pockets at low temperatures...
January 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28097772/laser-irradiation-induced-melting-and-reduction-reaction-for-the-formation-of-pt-based-bimetallic-alloy-particles-in-liquids
#5
Changhao Liang, Shouliang Wu, Enmei Dai, Yixing Ye, Jun Liu, Zhenfei Tian, Yunyu Cai, Xiaoguang Zhu, Yechuang Han
Laser melting in liquids (LML) is one of the most effective methods to prepare bimetallic alloys, the formation process of which is always research focus but still ambiguous. In this paper, we prepared two types of Pt-based bimetallic alloys by LML, including Pt-Au alloys and Pt-iron group metal (iM = Fe/Co/Ni) alloys, and investigated the corresponding mechanisms of alloying process. Detailed component and structural characterizations indicate that laser irradiation induced a quite rapid formation process (not exceed 10 s) of Pt-Au alloy nanospheres, and the crystalline structures of Pt-Au alloys is determined by the monometallic constituents with higher content...
January 18, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28097755/a-solution-processable-liquid-crystalline-semiconductor-for-low-temperature-annealed-air-stable-n-channel-field-effect-transistors
#6
Resul Ozdemir, Donghee Choi, Mehmet Ozdemir, Hyekyoung Kim, Sinem Tuncel Kostakoğlu, Mustafa Erkartal, Hyungsug Kim, Choongik Kim, Hakan Usta
A new solution-processable and air-stable liquid-crystalline n-channel organic semiconductor (α,ω-2OD-TIFDMT) employing a donor-acceptor-donor (D-A-D) type of π-conjugation has been designed, synthesized, and fully characterized. The new semiconductor exhibits a low LUMO energy (-4.19 eV) and a narrow optical band gap (1.35 eV). Typical pseudo focal-conic fan-shaped texture of a hexagonal columnar liquid crystalline (LC) phase was observed over a wide temperature range. The spin-coated semiconductor thin-films shows the formation of large (~0...
January 17, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28097424/analysis-of-the-spleen-proteome-of-chickens-infected-with-reticuloendotheliosis-virus
#7
Mei Xue, Yan Zhao, Shunlei Hu, Xingming Shi, Hongyu Cui, Yunfeng Wang
Infection with reticuloendotheliosis virus (REV), a gammaretrovirus in the family Retroviridae, can result in immunosuppression and subsequent increased susceptibility to secondary infections. In the present study, we identified differentially expressed proteins in the spleens of chickens infected with the REV-A HLJ07I strain, using two-dimensional gel electrophoresis on samples from time points coinciding with different phases of the REV life cycle. Differentially expressed proteins were identified using one-dimensional liquid chromatography electrospray ionization tandem mass spectrometry (1D LC ESI MS/MS)...
January 17, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28096361/thermal-driven-domain-and-cargo-transport-in-lipid-membranes
#8
Emma L Talbot, Lucia Parolini, Jurij Kotar, Lorenzo Di Michele, Pietro Cicuta
Domain migration is observed on the surface of ternary giant unilamellar vesicles held in a temperature gradient in conditions where they exhibit coexistence of two liquid phases. The migration localizes domains to the hot side of the vesicle, regardless of whether the domain is composed of the more ordered or disordered phase and regardless of the proximity to chamber boundaries. The distribution of domains is explored for domains that coarsen and for those held apart due to long-range repulsions. After considering several potential mechanisms for the migration, including the temperature preferences for each lipid, the favored curvature for each phase, and the thermophoretic flow around the vesicle, we show that observations are consistent with the general process of minimizing the system's line tension energy, because of the lowering of line interface energy closer to mixing...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28095369/implanted-muon-spin-spectroscopy-on-2-o-adamantane-a-model-system-that-mimics-the-liquid-formula-see-text-glasslike-transitions
#9
M Romanini, J L Tamarit, L C Pardo, F J Bermejo, R Fernandez-Perea, F L Pratt
The transition taking place between two metastable phases in 2-O-adamantane, namely the [Formula: see text] cubic, rotator phase and the lower temperature P21/c, Z  =  4 substitutionally disordered crystal is studied by means of muon spin rotation and relaxation techniques. Measurements carried out under zero, weak transverse and longitudinal fields reveal a temperature dependence of the relaxation parameters strikingly similar to those exhibited by structural glass[Formula: see text]liquid transitions (Bermejo et al 2004 Phys...
January 17, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28095187/fast-extraction-of-polychlorinated-dibenzo-p-dioxin-and-polychlorinated-dibenzofuran-in-sewage-sludge-and-soil-samples
#10
Valéria F Andrade, Alisson F S Durães, Douglas L Cassimiro, Gevany P de Pinho, Flaviano O Silvério
The current environmental legislations recommend monitoring chemical contaminants such as polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans before the use of sewage sludge on the agricultural land. In this study, a solid-liquid extraction with low-temperature purification (SLE-LTP) was optimized and validated to determine 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,3,7,8-tetrachlorodibenzofuran in sewage sludge and soil samples. The analyses were performed by gas chromatography-mass spectrometry operating in the selective ion mode (GC-MS-SIM)...
January 17, 2017: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
https://www.readbyqxmd.com/read/28094828/highly-sensitive-and-fast-monolayer-ws2-phototransistors-realized-by-sns-nanosheet-decoration
#11
Zhiyan Jia, Songlin Li, Jianyong Xiang, Fusheng Wen, Xuan Bao, Shanghuai Feng, Ruilong Yang, Zhongyuan Liu
Two-dimensional chalcogenide monolayers are strong candidates for next-generation flexible and transparent optoelectronics. Due to the intrinsic ultrathin thickness and limited optical absorption, however, their responsivity is normally low. Here we develop a simple and low-cost method to fabricate high-performance hybrid phototransistors of monolayer WS2 with significantly enhanced responsivity and an extended spectral response range, by virtue of surface decoration with liquid-phase exfoliated SnS nanosheets (NSs)...
January 17, 2017: Nanoscale
https://www.readbyqxmd.com/read/28093968/quantification-of-etodolac-in-human-plasma-for-pharmacokinetics-and-bioequivalence-studies-in-27-korean-subjects
#12
Il-Dong Song, Je-Seop Kang, Hyun-Jin Kim, Se-Mi Kim, Dong-Xu Zhao, Shin-Hee Kim, Min-Young Chun, Kyuhyun Lee
We developed a simple and validated liquid chromatography tandem mass spectrometry(LC-MS/MS) for quantification of etodolac using pioglitazone as an internal standard (IS) to assess pharmacokinetics and to appraise bioequivalence of two formulations of etodolac (reference and tested) in 27 healthy Korean subjects. Isocratic mobile phase consisted of 10 mM ammonium formate and acetonitrile were used to separate the analytes on a Gemini C18 column. Also, analytes were analyzed by MS/MS in multiple reaction monitoring (MRM) mode using the transitions of (M+H)+ ions, m/z 288...
January 16, 2017: Drug Metabolism Letters
https://www.readbyqxmd.com/read/28093365/vitamin-b3-metal-organic-frameworks-as-potential-delivery-vehicles-for-therapeutic-nitric-oxide
#13
Rosana V Pinto, Fernando Antunes, João Pires, Vanessa Graça, Paula Brandão, Moisés L Pinto
: The synthesis and structural characterization of two isostructural metal (M=Ni, Co) 3D framework structure that integrate vitamin B3 building blocks with NO delivery capabilities and low toxicity is presented. The compounds with a formula [M2(μ2-H2O)(μ-vitamin B3)4]·2H2O contain two crystallographic distinct divalent metal centers connected by a bridging water and carboxylate group from vitamin B3. The porous compounds have the capability of storing and releasing nitric oxide (NO) in a slow and reversible manner, with released amounts of 2...
January 13, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28092003/validated-electrochemical-and-chromatographic-quantifications-of-some-antibiotic-residues-in-pharmaceutical-industrial-waste-water
#14
Heba K Ibrahim, Mona M Abdel-Moety, Sherif A Abdel-Gawad, Medhat A Al-Ghobashy, Mohamed Abdel Kawy
Realistic implementation of ion selective electrodes (ISEs) into environmental monitoring programs has always been a challenging task. This could be largely attributed to difficulties in validation of ISE assay results. In this study, the electrochemical response of amoxicillin trihydrate (AMX), ciprofloxacin hydrochloride (CPLX), trimethoprim (TMP), and norfloxacin (NFLX) was studied by the fabrication of sensitive membrane electrodes belonging to two types of ISEs, which are polyvinyl chloride (PVC) membrane electrodes and glassy carbon (GC) electrodes...
January 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28091930/non-equilibrium-molecular-dynamics-simulations-of-the-transient-ludwig-soret-effect-in-a-binary-lennard-jones-spline-mixture
#15
Bjørn Hafskjold
A binary isotope mixture of Lennard-Jones/spline particles at equilibrium was perturbed by a sudden change in the system's boundary temperatures. The system's response was determined by non-equilibrium molecular dynamics (NEMD). Three transient processes were studied: 1) The propagation of a pressure (shock) wave, 2) heat diffusivity and conduction, and 3) thermal diffusion (the Ludwig-Soret effect). These three processes occur at different time scales, which makes it possible to separate them in one single NEMD run...
January 2017: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/28091717/bar-adsorptive-microextraction-technique-application-for-the-determination-of-pharmaceuticals-in-real-matrices
#16
Carlos Almeida, Samir M Ahmad, José Manuel F Nogueira
In the present work, bar adsorptive microextraction using miniaturized devices (7.5 × 3.0 mm) coated with suitable sorbent phases, combined with microliquid desorption (100 μL) followed by high-performance liquid chromatography with diode array detection (BAμE-μLD/HPLC-DAD), is proposed for the determination of trace level of six pharmaceuticals (furosemide, mebeverine, ketoprofen, naproxen, diclofenac and mefenamic acid) in environmental water and urine matrices. By comparing ten distinct sorbent materials (five polymeric and five activated carbons), the polymer P5 proved to be the most suitable to achieve the best selectivity and efficiency...
January 16, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28091605/cubosomes-from-hierarchical-self-assembly-of-poly-ionic-liquid-block-copolymers
#17
Hongkun He, Khosrow Rahimi, Mingjiang Zhong, Ahmed Mourran, David R Luebke, Hunaid B Nulwala, Martin Möller, Krzysztof Matyjaszewski
Cubosomes are micro- and nanoparticles with a bicontinuous cubic two-phase structure, reported for the self-assembly of low molecular weight surfactants, for example, lipids, but rarely formed by polymers. These objects are characterized by a maximum continuous interface and high interface to volume ratio, which makes them promising candidates for efficient adsorbents and host-guest applications. Here we demonstrate self-assembly to nanoscale cuboidal particles with a bicontinuous cubic structure by amphiphilic poly(ionic liquid) diblock copolymers, poly(acrylic acid)-block-poly(4-vinylbenzyl)-3-butyl imidazolium bis(trifluoromethylsulfonyl)imide, in a mixture of tetrahydrofuran and water under optimized conditions...
January 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/28089273/high-performance-liquid-chromatography-analysis-of-100-nm-liposomal-nanoparticles-using-polymer-coated-silica-monolithic-columns-with-aqueous-mobile-phase
#18
Naoki Itoh, Arato Kimoto, Eiichi Yamamoto, Tatsuya Higashi, Tomofumi Santa, Takashi Funatsu, Masaru Kato
Recently, nanoparticles have garnered considerable attention, and the demand for a rapid and simple method for their analysis has increased accordingly. The bimodal pores (few μm- and few tens nm-sized pores) of monolithic columns were thought to be suitable for the separation of nanoparticles and small molecules; however, the residual silanol groups on the column surface resulted in the strong adsorption of liposomes and hindered their analysis. To overcome this problem, we modified the surface of the silica monolith via a two-step process and developed three silica monolithic columns coated with three different polymers: glycidyl methacrylate (GMA), 2-hydroxyethyl methacrylate (HEMA), and N-vinylpyrrolidone (VP)...
December 29, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28088457/preformulation-characterization-stabilization-and-formulation-design-for-the-acrylodan-labeled-glucose-binding-protein-sm4-ac
#19
Neha Sahni, Rajoshi Chaudhuri, John M Hickey, Prakash Manikwar, Ajit D'Souza, Andrew Metters, Sangeeta B Joshi, C Russell Middaugh, David B Volkin
This study describes the physicochemical characterization, stabilization and formulation design of SM4-AC, an acrylodan labeled glucose/galactose binding protein for use in a continuous glucose monitoring device. The physical stability profile of SM4-AC as a function of pH and temperature was monitored using a combination of biophysical techniques and the resulting physical stability profile was visualized using an empirical phase diagram. Forced degradation chemical stability studies (Asn deamidation, Met oxidation) of SM4-AC were performed using a combination of capillary isoelectric focusing (cIEF), peptide mapping and reversed phase high performance liquid chromatography (RP-HPLC)...
January 11, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28088372/nanoformulation-of-dual-bexarotene-tailed-phospholipid-conjugate-with-high-drug-loading
#20
Ruiyu He, Yawei Du, Longbing Ling, Muhammad Ismail, Yongpeng Hou, Chen Yao, Xinsong Li
Bexarotene (Bex), a synthetic retinoid X receptor-selective activator, has been proved to be an efficacious chemotherapeutic agent. But, its clinical application is limited due to the poor solubility. In this report, dual bexarotene-tailed phospholipid (DBTP) conjugate based nanovesicles were prepared in order to develop new nanoformulation. DBTP conjugate was first synthesized by conjugating two Bex molecules with glycerophosphorylcholine (GPC) through facial esterification. The amphiphilic DBTP nanovesicles were prepared without any additive by reverse-phase evaporation method...
January 11, 2017: European Journal of Pharmaceutical Sciences
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