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https://www.readbyqxmd.com/read/29791138/a-three-dimensional-printed-poly-vinyl-alcohol-substrate-with-controlled-on-demand-degradation-for-transient-electronics
#1
Jinsu Yoon, Jungmin Han, Bongsik Choi, Yongwoo Lee, Yeamin Kim, Jinhee Park, Meehyun Lim, Min-Ho Kang, Dae Hwan Kim, Dong Myong Kim, Sungho Kim, Sung-Jin Choi
Electronics that degrade after stable operation for a desired operating time, called transient electrons, are of great interest in many fields, including biomedical implants, secure memory devices, and environmental sensors. Thus, the development of transient materials is critical for the advancement of transient electronics and their applications. However, previous reports have mostly relied on achieving transience in aqueous solutions where the transience time is largely pre-determined based on the materials initially selected at the beginning of fabrication...
May 23, 2018: ACS Nano
https://www.readbyqxmd.com/read/29790574/investigations-on-velvet-regulatory-mutants-confirm-the-role-of-host-tissue-acidification-and-secretion-of-proteins-in-the-pathogenesis-of-botrytis-cinerea
#2
Nathalie Müller, Michaela Leroch, Julia Schumacher, David Zimmer, Anne Könnel, Klaus Klug, Thomas Leisen, David Scheuring, Frederik Sommer, Timo Mühlhaus, Michael Schroda, Matthias Hahn
The Botrytis cinerea VELVET complex regulates light-dependent development and virulence. The goal of this study was to identify common virulence defects of several VELVET mutants and to reveal their molecular basis. Growth, differentiation, physiology, gene expression and infection of fungal strains were analyzed, and quantitative comparisons of in planta transcriptomes and secretomes were performed. VELVET mutants showed reduced release of citric acid, the major acid secreted by the wild-type, whereas no significant role for oxalic acid was observed...
May 23, 2018: New Phytologist
https://www.readbyqxmd.com/read/29789921/intervertebral-disc-damage-models-in-organ-culture-a-comparison-of-annulus-fibrosus-cross-incision-versus-punch-model-under-complex-loading
#3
Daniela A Frauchiger, Samantha C W Chan, Lorin M Benneker, Benjamin Gantenbein
PURPOSE: Comparison of two annulus fibrosus injury models that mimic intervertebral disc (IVD) herniation, enabling the study of IVD behaviour under three loading regimes in a bovine organ culture model. METHODS: An injury was induced by custom-designed cross-incision tool or a 2-mm biopsy punch in IVDs. Discs were cultured for 14 days under (1) complex (compression and torsion), (2) static, and (3) no load. Disc height, mitochondrial activity, DNA and glycosaminoglycan (GAG) contents, and disc stiffness under complex load were determined...
May 22, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29784458/efficacy-of-antiepileptic-drugs-in-the-adjunctive-treatment-of-refractory-partial-onset-seizures-meta-analysis-of-pivotal-trials
#4
Jeremy Slater, Steve Chung, Lynn Huynh, Mei Sheng Duh, Brian Gorin, Carolyn McMicken, Adam Ziemann, Jouko Isojarvi
OBJECTIVE: In the absence of randomized clinical trials (RCTs) assessing the relative efficacy of antiepileptic drugs (AEDs), meta-analyses are useful resources for informing treatment choices. This meta-analysis assesses the relative efficacy and tolerability of AEDs for adjunctive treatment of refractory partial onset seizures (POS). METHODS: A systematic literature review was conducted to identify pivotal AED trials serving as the basis for US Food and Drug Administration (FDA) approval...
July 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29784326/changes-in-chemical-and-sensory-properties-of-amarone-wine-produced-by-penicillium-infected-grapes
#5
Giacomo Zapparoli, Marilinda Lorenzini, Emanuele Tosi, Michela Azzolini, Davide Slaghenaufi, Maurizio Ugliano, Barbara Simonato
There is very little information on effects of Penicillium on aroma of passito wine. This study analyzed chemical composition and sensory properties of Amarone wines produced from withered grapes artificially contaminated by P. expansum or P. crustosum. Changes in properties of the two wines were evident by comparing wines obtained from healthy and Botrytis cinerea infected grapes used as controls. Penicillium infection affected primary and volatile composition of Amarone wine. Sensory profiles of these wines, obtained by descriptive analysis, resulted in clear differences in the wines between themselves and the control wines...
October 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29774807/robotic-pyelolithotomy-extended-pyelolithotomy-nephrolithotomy-and-anatrophic-nephrolithotomy
#6
Rabii Madi, Ashok Hemal
INTRODUCTION: We are a reporting on the indications, techniques, and limitations of robotic surgery in the management of renal stones disease. Robotic surgery is a good tool to manage large kidney and ureteral stones, particularly in patients with anatomic anomalies. We describe three techniques in managing staghorn kidney stones: robotic anatrophic nephrolithotomy, robotic pyelolithotomy, and robotic nephrolithotomy. MATERIAL AND METHODS: Robotic pyelolithotomy (RP) is ideal for patients with large renal pelvis and partial staghorn stone with a wide extra-renal pelvis...
May 2018: Journal of Endourology
https://www.readbyqxmd.com/read/29774542/accelerated-pre-senile-systemic-amyloidosis-in-pacap-knockout-mice-a-protective-role-of-pacap-in-age-related-degenerative-processes
#7
Dora Reglodi, Adel Jungling, Rémi Longuespée, Joerg Kriegsmann, Rita Casadonte, Mark Kriegsmann, Tamas Juhasz, Sebastian Bardosi, Andrea Tamas, Balazs Daniel Fulop, Krisztina Kovacs, Zsuzsanna Nagy, Jason Sparks, Attila Miseta, Gabriel Mazzucchelli, Hitoshi Hashimoto, Attila Bardosi
Dysregulation of neuropeptides may play an important role in aging-induced impairments. Among them, pituitary adenylate cyclase activating polypeptide (PACAP) is a potent cytoprotective peptide that provides an endogenous control against a variety of tissue-damaging stimuli. We hypothesized that the progressive decline of PACAP throughout life, and the well-known general cytoprotective effects of PACAP lead to age-related pathophysiological changes in PACAP deficiency, supported by the increased vulnerability to various stressors of animals partially or totally lacking PACAP...
May 17, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29758070/rapamycin-independent-igf2-expression-in-tsc2-null-mouse-embryo-fibroblasts-and-human-lymphangioleiomyomatosis-cells
#8
Blanca E Himes, Kseniya Obraztsova, Lurong Lian, Maya Shumyatcher, Ryan Rue, Elena N Atochina-Vasserman, Stella K Hur, Marisa S Bartolomei, Jilly F Evans, Vera P Krymskaya
Lymphangioleiomyomatosis (LAM) is a rare, almost exclusively female lung disease linked to inactivating mutations in tuberous sclerosis complex 2 (TSC2), a tumor suppressor gene that controls cell metabolic state and growth via regulation of the mechanistic target of rapamycin (mTORC1) signaling. mTORC1 is frequently activated in human cancers and, although the mTORC1 inhibitor rapamycin has a cytostatic effect, it is, in general, unable to elicit a robust curative effect or tumor regression. Using RNA-Seq, we identified (1) Insulin-like Growth Factor (IGF2) as one of the genes with the highest fold-change difference between human TSC2-null and TSC2-expressing angiomyolipoma cells from a patient with LAM, and (2) the mouse IGF2 homolog Igf2, as a top-ranking gene according to fold change between Tsc2-/- and Tsc2+/+ mouse embryo fibroblasts (MEFs)...
2018: PloS One
https://www.readbyqxmd.com/read/29748601/trabid-inhibits-hepatocellular-carcinoma-growth-and-metastasis-by-cleaving-rnf8-induced-k63-ubiquitination-of-twist1
#9
Yuekun Zhu, Chao Qu, Xuehui Hong, Yanyan Jia, Meihu Lin, Yunmei Luo, Fengqin Lin, Xiaolong Xie, Xiaoqi Xie, Juan Huang, Qin Wu, Xingfeng Qiu, Daxun Piao, Yanwei Xing, Tian Yu, Yuanfu Lu, Qiang Huang, Changyin Yu, Junfei Jin, Zhiyong Zhang
TRAF-binding domain (Trabid), one of deubiquitination enzymes, was recently reported to activate Wnt/ β-catenin signaling pathway. However, the role of Trabid in tumors including hepatocellular carcinoma (HCC) and the underlying mechanisms controlling its activity remain poorly understood. Here, we report that Trabid is significantly downregulated in HCC tumor samples and cell lines compared with normal controls and that its expression level is negatively correlated with HCC pathological grading, recurrence, and metastasis...
May 10, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29745347/febrile-infection-related-epilepsy-syndrome-fires-an-overview-of-treatment-and-recent-patents
#10
Kam Lun E Lun Hon, Alexander K C Leung, Alcy R Torres
BACKGROUND: New-onset refractory status epilepticus (NORSE) refers to a clinical presentation in a patient without active epilepsy or other existing relevant neurological disorder, with new onset of refractory status epilepticus in the absence of a clear acute or active structural, metabolic, or toxic cause. Febrile infection-related epilepsy syndrome (FIRES) is a subset of NORSE that requires a febrile infection between 24 hours and 2 weeks prior to the onset of refractory status epilepticus, with or without fever at the onset of status epilepticus, and with no restriction to the age of the patient...
May 8, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/29740285/ovarian-function-modulates-the-effects-of-long-chain-polyunsaturated-fatty-acids-on-the-mouse-cerebral-cortex
#11
Jose L Herrera, Lara Ordoñez-Gutierrez, Gemma Fabrias, Josefina Casas, Araceli Morales, Guadalberto Hernandez, Nieves G Acosta, Covadonga Rodriguez, Luis Prieto-Valiente, Luis M Garcia-Segura, Rafael Alonso, Francisco G Wandosell
Different dietary ratios of n -6/ n -3 long-chain polyunsaturated fatty acids (LC-PUFAs) may alter brain lipid profile, neural activity, and brain cognitive function. To determine whether ovarian hormones influence the effect of diet on the brain, ovariectomized and sham-operated mice continuously treated with placebo or estradiol were fed for 3 months with diets containing low or high n -6/ n -3 LC-PUFA ratios. The fatty acid (FA) profile and expression of key neuronal proteins were analyzed in the cerebral cortex, with intact female mice on standard diet serving as internal controls of brain lipidome composition...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29735044/microparticulated-whey-protein-pectin-complex-a-texture-controllable-gel-for-low-fat-mayonnaise
#12
Chanchan Sun, Rui Liu, Bin Liang, Tao Wu, Wenjie Sui, Min Zhang
This article reports caloric value changes, stability and rheological properties of mayonnaises affected by fat mimetic based on Microparticulated whey protein (MWP) and high-methoxy pectin. Lipid was partially substituted at different levels of 20%, 40%, 60%, 80% and 100%, and the samples were referred to as FM20, FM40, FM60, FM80 and FFM, respectively. The full fat (FF) mayonnaise was used as a control experiment. For rheological properties, the addition of fat mimetic resulted in the gradual decrease of pseudoplastic behavior, relative thixotropic area and viscosity index, while elasticity index exhibited the opposite trend...
June 2018: Food Research International
https://www.readbyqxmd.com/read/29729897/injectable-magnetic-supramolecular-hydrogel-with-magnetocaloric-liquid-conformal-property-prevents-the-post-operative-recurrence-in-a-breast-cancer-model
#13
Haoan Wu, Lina Song, Ling Chen, Wei Zhang, Yi Chen, Fengchao Zang, Hong Chen, Ming Ma, Ning Gu, Yu Zhang
Locoregional recurrence of breast cancer after tumor resection represents several clinical challenges. Here, we demonstrate that co-delivery of chemotherapy and thermotherapeutic agents by a magnetic supramolecular hydrogel (MSH) following tumor resection prevents tumor recurrence in a breast cancer mouse model. The self-assembled MSH was designed through the partial inclusion complexation associated with the threading of α-CD on the copolymer moieties on the surface of the PEGylated iron oxide (Fe3 O4 ) nanoparticles, which enables shear-thinning injection and controllable thermoreversible gel-sol transition...
May 3, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29728888/omega-3-fatty-acids-attenuate-brain-alterations-in-high-fat-diet-induced-obesity-model
#14
Aline Haas de Mello, Rosiane de Bona Schraiber, Mariana Pereira de Souza Goldim, Michelle Lima Garcez, Maria Luiza Gomes, Gustavo de Bem Silveira, Rubya Pereira Zaccaron, Patrícia Fernanda Schuck, Josiane Budni, Paulo Cesar Lock Silveira, Fabricia Petronilho, Gislaine Tezza Rezin
This study evaluated the effects of omega-3 on inflammation, oxidative stress, and energy metabolism parameters in the brain of mice subjected to high-fat diet-induced obesity model. Body weight and visceral fat weight were evaluated as well. Male Swiss mice were divided into control (purified low-fat diet) and obese (purified high-fat diet). After 6 weeks, the groups were divided into control + saline, control + omega-3, obese + saline, and obese + OMEGA-3. Fish oil (400 mg/kg/day) or saline solution was administrated orally, during 4 weeks...
May 4, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29726880/electrowetting-driven-solar-indoor-lighting-e-sil-an-optofluidic-approach-towards-sustainable-buildings
#15
Si Kuan Thio, Dongyue Jiang, Sung-Yong Park
Optofluidics is an emerging research field that combines the two disciplines of microfluidics and optics. By using microfluidic technologies for light control, optofluidic devices can offer several advantages over solid-type optical components, including optical-grade smoothness at the fluidic interface and a high degree of optical tunability without bulky and complex mechanical moving parts. These features have made optofluidic devices more versatile and reconfigurable to improve their optical performances...
May 4, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29726311/the-romantic-relationship-experiences-of-young-adult-women-exposed-to-domestic-violence
#16
Megan L Haselschwerdt, Camille E Carlson, Kathleen Hlavaty
Guided by a review of the literature on intergenerational transmission of violence, or "the cycle of violence", and Johnson's typology of domestic violence, the current study qualitatively examined the romantic relationship experiences of 23 young adult women who were exposed to father-mother-perpetrated domestic violence (DV) during childhood and adolescence. Findings are partially consistent with the hypothesis that DV exposure is associated with an increased risk of later experiencing dating violence, such that half of the sample reported having abusive partners or relationships during high school...
May 1, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29723709/aiding-the-search-examining-individual-differences-in-multiply-constrained-problem-solving
#17
Derek M Ellis, Gene A Brewer
Understanding and resolving complex problems is of vital importance in daily life. Problems can be defined by the limitations they place on the problem solver. Multiply-constrained problems are traditionally examined with the compound remote associates task (CRAT). Performance on the CRAT is partially dependent on an individual's working memory capacity (WMC). These findings suggest that executive processes are critical for problem solving and that there are reliable individual differences in multiply-constrained problem solving abilities...
April 27, 2018: Consciousness and Cognition
https://www.readbyqxmd.com/read/29722913/the-tsc1-mtor-plk-axis-regulates-the-homeostatic-switch-from-schwann-cell-proliferation-to-myelination-in-a-stage-specific-manner
#18
Minqing Jiang, Rohit Rao, Jincheng Wang, Jiajia Wang, Lingli Xu, Lai Man Wu, Jonah R Chan, Huimin Wang, Q Richard Lu
Proper peripheral myelination depends upon the balance between Schwann cell proliferation and differentiation programs. The serine/threonine kinase mTOR integrates various environmental cues to serve as a central regulator of cell growth, metabolism, and function. We report here that tuberous sclerosis complex 1 (TSC1), a negative regulator of mTOR activity, establishes a stage-dependent program for Schwann cell lineage progression and myelination by controlling cell proliferation and myelin homeostasis. Tsc1 ablation in Schwann cell progenitors in mice resulted in activation of mTOR signaling, and caused over-proliferation of Schwann cells and blocked their differentiation, leading to hypomyelination...
May 3, 2018: Glia
https://www.readbyqxmd.com/read/29719920/quantification-of-the-central-cardiovascular-network-applying-the-normalized-short-time-partial-directed-coherence-approach-in-healthy-subjects
#19
Steffen Schulz, Mathias Bolz, Karl-Jürgen Bär, Andreas Voss
BACKGROUND: The central control of the autonomic nervous system (ANS) and the complex interplay of its components can be described by a functional integrated mode - the central autonomic network (CAN). CAN represents the integrated functioning and interaction between the central nervous system (CNS) and ANS (parasympathetic and sympathetic activity). OBJECTIVE: This study investigates the central cardiovascular network (CCVN) as a part of the CAN, during which heart rate (HR), systolic blood pressure (SYS) and frontal EEG activity in 21 healthy subjects (CON) will be analysed...
May 2018: Methods of Information in Medicine
https://www.readbyqxmd.com/read/29717652/training-in-goal-oriented-attentional-self-regulation-improves-executive-functioning-in-veterans-with-chronic-tbi
#20
Tatjana Novakovic-Agopian, Erica S Kornblith, Gary Abrams, Joaquin Burciaga-Rosales, Fred Loya, Mark D'Esposito, Anthony J-W Chen
Deficits in executive control functions are some of the most common and disabling consequences of both military and civilian brain injury. However, effective interventions are scant. The goal of this study was to assess whether cognitive rehabilitation training that was successfully applied in chronic civilian brain injury would be effective for military Veterans with TBI. In a prior study, participants with chronic acquired brain injury significantly improved after training in goal-oriented attentional self-regulation (GOALS) on measures of attention/executive function, functional task performance, and goal-directed control over neural processing on fMRI...
May 2, 2018: Journal of Neurotrauma
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