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https://www.readbyqxmd.com/read/28917534/modeling-the-modified-drug-release-from-curved-shape-drug-delivery-systems-dome-matrix-%C3%A2
#1
D Caccavo, A A Barba, M d'Amore, R De Piano, G Lamberti, A Rossi, P Colombo
The controlled drug release from hydrogel-based drug delivery systems is a topic of large interest for research in pharmacology. The mathematical modeling of the behavior of these systems is a tool of emerging relevance, since the simulations can be of use in the design of novel systems, in particular for complex shaped tablets. In this work a model, previously developed, was applied to complex-shaped oral drug delivery systems based on hydrogels (Dome Matrix®). Furthermore, the model was successfully adopted in the description of drug release from partially accessible Dome Matrix® systems (systems with some surfaces coated)...
September 13, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28916964/presence-of-a-3fe-4s-cluster-in-a-psac-variant-as-a-functional-component-of-the-photosystem-i-electron-transfer-chain-in-synechococcus-sp-pcc-7002
#2
Adam A Pérez, Bryan H Ferlez, Amanda M Applegate, Karim Walters, Zhihui He, Gaozhong Shen, John H Golbeck, Donald A Bryant
A site-directed C14G mutation was introduced into the stromal PsaC subunit of Synechococcus sp. strain PCC 7002 in vivo in order to introduce an exchangeable coordination site into the terminal FB [4Fe-4S] cluster of Photosystem I (PSI). Using an engineered PSI-less strain (psaAB deletion), psaC was deleted and replaced with recombinant versions controlled by a strong promoter, and the psaAB deletion was complemented. Modified PSI accumulated at lower levels in this strain and supported slower photoautotrophic growth than wild type...
September 15, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/28915209/the-expanded-use-of-auto-augmentation-techniques-in-oncoplastic-breast-surgery
#3
Albert Losken, Alexandra M Hart, James Walter Dutton, Justine S Broecker, Toncred M Styblo, Grant W Carlson
BACKGROUND: Auto-augmentation techniques have been applied to oncoplastic reductions to assist with filling larger, more remote defects and women with smaller breasts. The purpose of this report is to describe the use of auto-augmentation techniques in OR and compare the results with traditional OR. METHODS: We queried a prospectively maintained database of all women who underwent partial mastectomy and OR between 1994 and October 2015. The auto-augmentation techniques were defined as 1) extended primary nipple auto-augmentation pedicle, and 2) primary nipple pedicle and secondary auto-augmentation pedicle...
September 13, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28912587/tuning-electromagnetic-properties-of-srruo3-epitaxial-thin-films-via-atomic-control-of-cation-vacancies
#4
Sang A Lee, Seokjae Oh, Jegon Lee, Jae-Yeol Hwang, Jiwoong Kim, Sungkyun Park, Jong-Seong Bae, Tae Eun Hong, Suyoun Lee, Sung Wng Kim, Won Nam Kang, Woo Seok Choi
Elemental defect in transition metal oxides is an important and intriguing subject that result in modifications in variety of physical properties including atomic and electronic structure, optical and magnetic properties. Understanding the formation of elemental vacancies and their influence on different physical properties is essential in studying the complex oxide thin films. In this study, we investigated the physical properties of epitaxial SrRuO3 thin films by systematically manipulating cation and/or oxygen vacancies, via changing the oxygen partial pressure (P(O2)) during the pulsed laser epitaxy (PLE) growth...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28906392/comparison-of-fertility-sparing-treatments-in-patients-with-early-endometrial-cancer-and-atypical-complex-hyperplasia-a-meta-analysis-and-systematic-review
#5
Jing Wei, Weiyuan Zhang, Limin Feng, Wanli Gao
BACKGROUND: There are some fertility-sparing treatments in patients with early endometrial cancer (EEC) or atypical complex hyperplasia (ACH), and the objective is to compare them by evaluating the oncologic and reproductive outcomes. METHODS: We searched the published literature using Medline, Cochrane, EMBASE, and Google Scholar databases up to January 3, 2017, with various combinations of keywords fertility-sparing treatments, progesterone, progestin, intrauterine devices, early endometrial cancer, and atypical complex hyperplasia...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28906271/neurosensory-disturbance-of-the-inferior-alveolar-nerve-after-3025-implant-placements
#6
Antonio Scarano, Bruna Sinjari, Giovanna Murmura, Felice Lorusso
PURPOSE: The aim of this retrospective study was to evaluate the incidence of inferior alveolar nerve (IAN) lesion and duration of sensitivity disturbances after the insertion of dental implants. METHODS: One thousand sixty-five patients (mean age: 58.9 years) enrolled between February 2004 and July 2015 with partial or full mandibular edentulism were selected to receive dental implants for oral rehabilitation. A total of 3025 implants were placed. After surgical procedures, controls were scheduled at suture removal, that is, 10 days after surgery, and repeated at intervals of 1, 3, and 6 months, and comprised patient interview, clinical examination, and sensitivity tests...
September 12, 2017: Implant Dentistry
https://www.readbyqxmd.com/read/28894215/gene-expression-of-nox-family-members-and-their-clinical-significance-in-hepatocellular-carcinoma
#7
Hyuk Soo Eun, Sang Yeon Cho, Jong Seok Joo, Sun Hyung Kang, Hee Seok Moon, Eaum Seok Lee, Seok Hyun Kim, Byung Seok Lee
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex-derived reactive oxygen species (ROS) promote chronic liver inflammation and remodeling that can drive hepatocellular carcinoma development. The role of NOX expression in hepatocellular carcinoma (HCC) has been partially investigated; however, the clinical relevance of collective or individual NOX family member expression for HCC survival remains unclear. Here, we obtained NOX mRNA expression data for 377 HCC samples and 21 normal liver controls from the TCGA data portal and performed Kaplan-Meier survival, gene ontology functional enrichment, and gene set enrichment analyses...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28889223/response-of-anaerobic-membrane-bioreactor-to-the-presence-of-nano-bi2wo6-reactor-performance-supernatant-characteristics-and-microbial-community
#8
Lin Chen, Yue Wang, Chuqing Cao, Chang Liu, Liang Zhu
Considering the increasing incorporation of manufactured nano-material into consumer products, there is a concern about its potential impacts in biological wastewater treatment. In this study, the response of anaerobic sludge to the presence of Bi2WO6 nano-particles (NPs) was investigated in the anaerobic membrane bioreactor (AnMBR). As the concentration of Bi2WO6 in the reactor was controlled around 1 mg/L, there was no significant difference in effluent water quality or bacterial activities before and after NP exposure, partially due to the microbial-induced NP aggregation and stable complex formation...
September 9, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28888219/factor-xa-inhibition-by-rivaroxaban-in-the-trough-steady-state-can-significantly-reduce-thrombin-generation
#9
Shigeo Horinaka, Rie Sugawara, Yutaka Yonezawa, Toshihiko Ishimitsu
AIMS: The aim of the present study was to demonstrate evidence of reduced thrombin generation at the trough plasma rivaroxaban concentration. METHODS: A single-centre, prospective, non-randomised, drug intervention, self-controlled study was conducted in 51 anticoagulation therapy-naïve patients with non-valvular atrial fibrillation. Plasma rivaroxaban concentration was measured by liquid chromatography tandem mass spectrometry (LC-MS/MS) and anti-factor Xa chromogenic assay...
September 9, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28887160/silencing-of-the-pentose-phosphate-pathway-genes-influences-dna-replication-in-human-fibroblasts
#10
Karolina Fornalewicz, Aneta Wieczorek, Grzegorz Węgrzyn, Robert Łyżeń
Previous reports and our recently published data indicated that some enzymes of glycolysis and the tricarboxylic acid cycle can affect the genome replication process by changing either the efficiency or timing of DNA synthesis in human normal cells. Both these pathways are connected with the pentose phosphate pathway (PPP pathway). The PPP pathway supports cell growth by generating energy and precursors for nucleotides and amino acids. Therefore, we asked if silencing of genes coding for enzymes involved in the pentose phosphate pathway may also affect the control of DNA replication in human fibroblasts...
September 5, 2017: Gene
https://www.readbyqxmd.com/read/28884431/angiotensin-ii-at2-receptors-contribute-to-regulate-the-sympathoadrenal-and-hormonal-reaction-to-stress-stimuli
#11
REVIEW
J M Saavedra, I Armando
Angiotensin II, through AT1 receptor stimulation, mediates multiple cardiovascular, metabolic, and behavioral functions including the response to stressors. Conversely, the function of Angiotensin II AT2 receptors has not been totally clarified. In adult rodents, AT2 receptor distribution is very limited but it is particularly high in the adrenal medulla. Recent results strongly indicate that AT2 receptors contribute to the regulation of the response to stress stimuli. This occurs in association with AT1 receptors, both receptor types reciprocally influencing their expression and therefore their function...
September 7, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28881131/where-ion-mobility-and-molecular-dynamics-meet-to-unravel-the-un-folding-mechanisms-of-an-oligorotaxane-molecular-switch
#12
Emeline Hanozin, Benoit Mignolet, Denis Morsa, Damien Sluysmans, Anne-Sophie Duwez, J Fraser Stoddart, Françoise Remacle, Edwin De Pauw
At the interface between foldamers and mechanically interlocked molecules, oligorotaxanes exhibit a spring-like folded secondary structure with remarkable mechanical and physicochemical properties. Among these properties, the ability of oligorotaxanes to act as molecular switches through controlled modulations of their spatial extension over (un)folding dynamics is of particular interest. The present study aims to assess and further characterize this remarkable feature in the gas phase using mass spectrometry tools...
September 13, 2017: ACS Nano
https://www.readbyqxmd.com/read/28877970/the-transcriptional-response-of-candida%C3%A2-albicans-to-weak-organic-acids-carbon-source-and-mig1%C3%A2-inactivation-unveils-a-role-for-hgt16-in-mediating-the-fungistatic-effect-of-acetic-acid
#13
Fabien Cottier, Alrina Shin Min Tan, Marina Yurieva, Webber Liao, Josephine Lum, Michael Poidinger, Francesca Zolezzi, Norman Pavelka
Candida albicans is a resident fungus of the human intestinal microflora. Commonly isolated at low abundance in healthy people, C. albicans outcompetes local microbiota during candidiasis episodes. Under normal conditions, members of the human gastrointestinal microbiota were shown to keep C. albicans colonization under control. By releasing weak organic acids (WOAs), bacteria are able to moderate yeast growth. This mechanism displayed a synergistic effect in vitro with the absence of glucose in medium of culture, which underline the complex interaction that C...
September 6, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28876533/multi-objective-optimization-of-benzamide-derivatives-as-rho-kinase-inhibitors
#14
Giovanna Cardoso Gajo, Daniela Rodrigues Silva, Stephen J Barigye, Elaine Fontes Ferreira da Cunha
Despite recent advances in Computer Aided Drug Discovery and High Throughput Screening, the attrition rates of drug candidates continue to be high, underscoring the inherent complexity of the drug discovery paradigm. Indeed, a compromise between several objectives is often required to obtain successful clinical drugs. The present manuscript details a multi-objective workflow that integrates the 4D-QSAR and molecular docking methods in the simultaneous modeling of the Rho Kinase inhibitory activity and acute toxicity of Benzamide derivatives...
September 6, 2017: Molecular Informatics
https://www.readbyqxmd.com/read/28874192/plasma-metabolomic-study-in-chinese-patients-with-wet-age-related-macular-degeneration
#15
Dan Luo, Tingting Deng, Wei Yuan, Hui Deng, Ming Jin
BACKGROUND: Age-related macular degeneration (AMD) is a leading disease associated with blindness. It has a high incidence and complex pathogenesis. We aimed to study the metabolomic characteristics in Chinese patients with wet AMD by analyzing the morning plasma of 20 healthy controls and 20 wet AMD patients for metabolic differences. METHODS: We used ultra-high-pressure liquid chromatography and quadrupole-time-of-flight mass spectrometry for this analysis. The relationship of these differences with AMD pathophysiology was also assessed...
September 6, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28865975/membrane-nanodomains-and-microdomains-in-plant-microbe-interactions
#16
REVIEW
Thomas Ott
During plant-microbe interactions, host cells need to keep stringent control over the approaching pathogens and symbionts. This requires specific spatio-temporal assemblies of pattern recognition receptors and other complex constituents and a strict physical separation of genetically overlapping pathways. Increasing evidence suggests that this is, at least partially, achieved by the formation of nanometer scale membrane platforms that might act as signaling hubs. These and other larger-scale sub-compartments have been termed 'membrane rafts', 'nanodomains' and 'microdomains'...
August 31, 2017: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/28864671/expression-of-an-rna-glycosidase-inhibits-hiv-1-transactivation-of-transcription
#17
Meherzad Kutky, Katalin A Hudak
HIV-1 transcription is primarily controlled by the virally encoded Tat protein and its interaction with the viral TAR RNA element. Specifically, binding of a Tat-containing complex to TAR recruits cellular factors that promote elongation of the host RNA polymerase engaging the viral DNA template. Disruption of this interaction halts viral RNA transcription. In this study, we investigated the effect of pokeweed antiviral protein (PAP), an RNA glycosidase (EC#: 3.2.2.22) synthesized by the pokeweed plant ( Phytolacca americana ), on transcription of HIV-1 mRNA...
September 1, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28864208/a-new-mechanism-of-inhibition-of-il-1%C3%AE-secretion-by-celastrol-through-the-nlrp3-inflammasome-pathway
#18
Wenyu Xin, Qiaoyun Wang, Dan Zhang, Chaoyun Wang
The NLRP3 (NOD-like receptor protein 3) inflammasome is a caspase-1-containing multiprotein complex that controls the release of IL-1β and has been associated with the development of inflammatory diseases. Celastrol, a pharmacologically active ingredient extracted from Tripterygium wilfordii Hook, has anti-inflammatory activities based on its inhibition of IL-1β secretion. The purpose of the present study was to investigate the possible modulation of NLRP3 inflammasome-mediated IL-1β and IL-18 release from macrophages by celastrol...
August 29, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28862869/a-model-order-reduction-algorithm-for-estimating-the-absorption-spectrum
#19
Roel Van Beeumen, David B Williams-Young, Joseph M Kasper, Chao Yang, Esmond G Ng, Xiaosong Li
The \emph{ab initio} description of the spectral interior of the absorption spectrum poses both a theoretical and computational challenge for modern electronic structure theory. Due to the often spectrally dense character of this domain in the quantum propagator's eigenspectrum for medium-to-large sized systems, traditional approaches based on the partial diagonalization of the propagator often encounter oscillatory and stagnating convergence. Electronic structure methods which solve the molecular response problem through the solution of spectrally shifted linear systems, such as the complex polarization propagator, offer an alternative approach which is agnostic to the underlying spectral density or domain location...
September 1, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28860591/experimental-methods-for-the-palaeolithic-dry-distillation-of-birch-bark-implications-for-the-origin-and-development-of-neandertal-adhesive-technology
#20
P R B Kozowyk, M Soressi, D Pomstra, G H J Langejans
The destructive distillation of birch bark to produce tar has recently featured in debates about the technological and cognitive abilities of Neandertals and modern humans. The abilities to precisely control fire temperatures and to manipulate adhesive properties are believed to require advanced mental traits. However, the significance given to adhesive technology in these debates has quickly outgrown our understanding of birch bark tar and its manufacture using aceramic techniques. In this paper, we detail three experimental methods of Palaeolithic tar production ranging from simple to complex...
August 31, 2017: Scientific Reports
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