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Vitamin B2

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https://www.readbyqxmd.com/read/28911508/relationship-of-pcsk9-and-urinary%C3%A2-thromboxane-excretion-to%C3%A2-cardiovascular-events-in-patients%C3%A2-with%C3%A2-atrial-fibrillation
#1
Daniele Pastori, Cristina Nocella, Alessio Farcomeni, Simona Bartimoccia, Maria Santulli, Fortunata Vasaturo, Roberto Carnevale, Danilo Menichelli, Francesco Violi, Pasquale Pignatelli
BACKGROUND: Soluble proprotein convertase subtilisin/kexin type 9 (PCSK9) has been shown to be predictive of cardiovascular events (CVEs) in patients who are at high cardiovascular risk. No data on the effect of PCSK9 levels in patients with atrial fibrillation (AF) are available. OBJECTIVES: This study investigated the association between PCSK9 and CVEs in AF as well as the relationship between PCSK9 and urinary 11-dehydro-thromboxane B2 (11-dh-TxB2), a marker of platelet activation...
September 19, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28911109/selective-tumor-cell-death-induced-by-irradiated-riboflavin-through-recognizing-dna-g-t-mismatch
#2
Yi Yuan, Yongyun Zhao, Lianqi Chen, Jiasi Wu, Gangyi Chen, Sheng Li, Jiawei Zou, Rong Chen, Jian Wang, Fan Jiang, Zhuo Tang
Riboflavin (vitamin B2) has been thought to be a promising antitumoral agent in photodynamic therapy, though the further application of the method was limited by the unclear molecular mechanism. Our work reveals that riboflavin was able to recognize G-T mismatch specifically and induce single-strand breaks in duplex DNA targets efficiently under irradiation. In the presence of riboflavin, the photo-irradiation could induce the death of tumor cells that are defective in mismatch repair system selectively, highlighting the G-T mismatch as potential drug target for tumor cells...
September 6, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28904494/vitamin-d-deficiency-does-not-influence-reproductive-outcomes-of-ivf-icsi-a-study-of-oocyte-donors-and-recipients
#3
Manish Banker, Dipesh Sorathiya, Sandeep Shah
BACKGROUND: Vitamin D and its active metabolite, 1,25-dihydroxy vitamin D (1,25-(OH)2D3), play a significant role in reproduction. AIM: To assess the effect of serum 25-hydroxy vitamin D level on oocyte quality and endometrial receptivity by studying oocyte donors and their recipients. MATERIALS AND METHODS: This prospective study consisted of two groups: Group A (recipient group) and Group B (donor group). All the participants of Groups A1 and B1 as well as Groups A2 and B2 were subcategorized into vitamin D-deficient (<20 ng/mL) and vitamin D replete-insufficient (20 to ≥30 ng/mL), respectively...
April 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/28899466/-clinical-features-and-etfdh-mutations-of-children-with-late-onset-glutaric-aciduria-type-ii-a-report-of-two-cases
#4
Yan-Yang Cheng, Yue Tang, Ao-Jie Liu, Li Wei, Lan Lin, Jing Zhang, Liang Zhi
OBJECTIVE: To investigate the clinical and genetic features of two families with late-onset glutaric aciduria type II caused by ETFDH mutations. METHODS: Target gene sequence capture and next generation sequencing were used for sequencing of suspected patients and their family members. The patients' clinical features were retrospectively analyzed and literature review was performed. RESULTS: The probands of the two families had a clinical onset at the ages of 10 years and 5...
September 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28895788/association-between-serum-unmetabolized-folic-acid-concentrations-and-folic-acid-from-fortified-foods
#5
Cecília Zanin Palchetti, Clóvis Paniz, Eduardo de Carli, Dirce M Marchioni, Célia Colli, Josiane Steluti, Christine M Pfeiffer, Zia Fazili, Elvira Maria Guerra-Shinohara
OBJECTIVE: To investigate the association between serum unmetabolized folic acid (UMFA) concentrations and folic acid from fortified foods and nutrients known as dietary methyl-group donors (folate, methionine, choline, betaine and vitamins B2, B6 and B12) in participants exposed to mandatory fortification of wheat and maize flours with folic acid. METHODS: Cross-sectional study carried out with 144 healthy Brazilian participants, both sexes, supplement nonusers...
September 12, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28890765/evaluation-of-nutritional-composition-of-the-dried-seaweed-ulva-lactuca-from-pameungpeuk-waters-indonesia
#6
Abdullah Rasyid
The nutritional composition of the dried seaweed Ulva lactuca from Pameungpeuk waters, including proximate, vitamins, minerals, dietary fibre and heavy metal has been carried out. The objective of this present study is to know the nutritional composition of the dried seaweed U. lactuca for utilisation in human nutrition in the future. Results show that carbohydrate was the major component in the proximate analysis of U. lactuca in the present study. The carbohydrate content was 58.1%. Moisture, ash, protein and fat content were 16...
July 2017: Tropical Life Sciences Research
https://www.readbyqxmd.com/read/28885755/effects-of-an-individualised-nutritional-education-and-support-programme-on-dietary-habits-nutritional-knowledge-and-nutritional-status-of-older-adults-living-alone
#7
Jeong-Ah Ahn, JeeWon Park, Chun-Ja Kim
AIMS AND OBJECTIVES: The effects of an individualised nutritional education and support programme on dietary habits, nutritional knowledge, and nutritional status of 71 older adults living alone were examined. BACKGROUND: Although a regular dietary meal plan is recommended for improving nutritional status of older adults living alone, little research is done in this field in Korea. DESIGN: A pre- and post-test controlled quasi-experimental design was used at public health centres...
September 7, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28877992/activation-of-human-mucosal-associated-invariant-t-cells-induces-cd40l-dependent-maturation-of-monocyte-derived-and-primary-dendritic-cells
#8
Mariolina Salio, Olivier Gasser, Claudia Gonzalez-Lopez, Anne Martens, Natacha Veerapen, Uzi Gileadi, Jacob G Verter, Giorgio Napolitani, Regan Anderson, Gavin Painter, Gurdyal S Besra, Ian F Hermans, Vincenzo Cerundolo
Mucosal-associated invariant T (MAIT) cells are innate T cells that recognize intermediates of the vitamin B2 biosynthetic pathway presented by the monomorphic MR1 molecule. It remains unclear whether, in addition to their cytolytic activity that is important in antimicrobial defense, MAIT cells have immune-modulatory functions that could enhance dendritic cell (DC) maturation. In this study, we investigated the molecular mechanisms dictating the interactions between human MAIT cells and DCs and demonstrate that human MAIT cells mature monocyte-derived and primary DCs in an MR1- and CD40L-dependent manner...
September 6, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28875857/is-there-a-link-between-vitamin-b-and-multiple-sclerosis
#9
Natalie Nemazannikova, Kathleen Mikkelsen, Lily Stojanovska, Gregory L Blatch, Vasso Apostolopoulos
BACKGROUND: Damage to the myelin sheath (demyelination) is one of the main manifestations of multiple sclerosis (MS). Interestingly, both MS and vitamin B deficiency results in severe myelin degeneration that leads to loss in neuronal signal transmission. OBJECTIVE: Deficiency in vitamin B complex vary, although common symptoms include fatigue, increased oxidative stress, inflammation and demyelination. In particular, vitamin B12 (cobalamin) has had increased attention for its role in the methylation process, involvement in myelination and re-myelination, and reversal of MS symptoms...
September 6, 2017: Medicinal Chemistry
https://www.readbyqxmd.com/read/28871327/micronutrient-intake-adequacy-and-depression-risk-in-the-sun-cohort-study
#10
Almudena Sánchez-Villegas, Aurora Pérez-Cornago, Itziar Zazpe, Susana Santiago, Francisca Lahortiga, Miguel Angel Martínez-González
PURPOSE: The aim of the study was to prospectively assess the association between micronutrient intake adequacy and risk of depression. METHODS: This dynamic cohort study involves Spanish university graduates (SUN Project). Dietary intake was assessed at baseline and after 10 years of follow-up with a semi-quantitative food frequency questionnaire. Micronutrient intake adequacy for vitamins B1, B2, B3, B6, B12, C, A, D, E, folic acid, zinc, iodine, selenium, iron, calcium, potassium, phosphorus, magnesium and chrome was estimated...
September 4, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28860694/evaluation-of-the-effect-of-corneal-collagen-cross-linking-for-keratoconus-on-the-ocular-higher-order-aberrations
#11
Ahmed Abdel-Karim El-Massry, Amgad Mostafa Dowidar, Tamer Hamdy Massoud, Baher Guirguis Daoud Tadros
BACKGROUND: Corneal collagen cross-linking (CXL) is the only treatment currently available to arrest the progression of keratoconus. The procedure consists of photopolymerization of stromal collagen fibers induced by combined action of a photosensitizing substance (riboflavin or vitamin B2) and ultraviolet-A light. PURPOSE: To determine changes in the ocular higher-order aberrations (HOAs) after CXL and its correlation with changes in visual acuity. DESIGN: Prospective interventional study...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28837684/association-of-peptic-ulcer-disease-with-obesity-nutritional-components-and-blood-parameters-in-the-korean-population
#12
Jihye Kim, Keun Ho Kim, Bum Ju Lee
OBJECTIVES: Peptic ulcer disease (PUD) is a common disorder, but whether an association exists between PUD and anthropometric indicators remains controversial. Furthermore, no studies on the association of PUD with anthropometric indices, blood parameters, and nutritional components have been reported. The aim of this study was to assess associations of anthropometrics, blood parameters, nutritional components, and lifestyle factors with PUD in the Korean population. METHODS: Data were collected from a nationally representative sample of the South Korean population using the Korea National Health and Nutrition Examination Survey...
2017: PloS One
https://www.readbyqxmd.com/read/28825603/nutritional-adequacy-of-the-specific-carbohydrate-diet-in-pediatric-inflammatory-bowel-disease
#13
Kimberly Braly, Nila Williamson, Michele L Shaffer, Dale Lee, Ghassan Wahbeh, Jani Klein, Matthew Giefer, David L Suskind
INTRODUCTION: The Specific Carbohydrate Diet (SCD) is an exclusion diet used as a therapy in inflammatory bowel disease (IBD). The aim of this study was to evaluate the nutritional adequacy of the SCD. METHODS: Prospective dietary data over 12 weeks were analyzed for pediatric patients on the SCD. Intake of 20 key nutrients was compared to Dietary Recommended Intake (DRI) levels and nutrient intake data from similarly aged children from The National Health and Nutrition Examination Survey (NHANES) National Youth Fitness Survey (NNYFS) in 2012...
April 27, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28822287/blue-light-induced-free-radicals-from-riboflavin-in-degradation-of-crystal-violet-by-microbial-viability-evaluation
#14
Ji-Yuan Liang, Jeu-Ming P Yuann, Zong-Jhe Hsie, Shiuh-Tsuen Huang, Chiing-Chang Chen
Crystal violet (CV) is applied in daily use mainly as a commercial dye and antimicrobial agent. Waste water containing CV may affect aquatic ecosystems. Riboflavin, also known as vitamin B2, is non-toxic and an essential vitamin required for the functions of the human body. Riboflavin is photosensitive to UV and visible light in terms of generating reactive oxygen species. This study investigated the potential application of blue light on riboflavin, so as to come up with an effective way of degrading CV during its treatment...
August 12, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28806113/-hungarian-diet-and-nutritional-status-survey-the-otap2014-study-v-vitamin-intake-of-the-hungarian-population
#15
Erzsébet Schreiberné Molnár, Zsuzsanna Nagy-Lőrincz, Barbara Nagy, Márta Bakacs, Orsolya Kis, Eszter Sarkadi Nagy, Éva Martos
INTRODUCTION AND AIM: The Hungarian Diet and Nutritional Status Survey was implemented on a sub-sample of the European Health Interview Survey. In this paper, the authors present the data on the vitamin intake of the Hungarian population. METHOD: The survey represents the vitamin intake of the Hungarian non-institutionalised adult population of 18 years and older. There are significant differences between men's and women's vitamin intake. RESULTS: The intake of all water-soluble vitamins except for vitamin C is higher in men than in women, and the difference between the genders regarding the intake of vitamin E and D is significant...
August 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28771433/the-impact-of-vitamin-c-on-the-relationship-among-inflammation-lipid-peroxidation-and-platelet-activation-during-analgesic-nephropathy-in-rats
#16
Nikola Hadzi-Petrushev, Dine Mitrov, Vladimir Kostovski, Mitko Mladenov
BACKGROUND: Oxidative stress and inflammation are involved in the pathogenesis of paracetamol-induced renal damage. This study examines the relationship between 8-iso-prostaglandin F2α (8-iso-PGF2α) and platelet activation as well as the relative contribution of the pro-inflammatory markers interleukin (IL)-1β and tumor necrosis factor-α (TNF-α) in enhanced 8-iso-PGF2α biosynthesis, as a complementary onset during analgesic nephropathy induced by chronic treatment with paracetamol...
August 3, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28710938/lack-of-effects-of-a-sobering-product-eezup-on-the-blood-ethanol-and-congener-alcohol-concentration
#17
Cora Wunder, Sarah Hain, Sarah C Koelzer, Alexander Paulke, Marcel A Verhoff, Stefan W Toennes
INTRODUCTION: The lifestyle product 'Eezup!' appeared on the German market and promised to normalize energy metabolism. Among vitamins (B1, B2, B6, C, E and zinc), rice protein and fructose the addition of alcohol dehydrogenase and catalase enzymes is a novel approach. The product was advertised as capable of boosting the rate of alcohol elimination. METHODS: Seventeen subjects (11 men, 6 women, 19-58 years old), participated in a two-way crossover drinking study...
September 2017: Forensic Science International
https://www.readbyqxmd.com/read/28710484/colored-and-fluorescent-nanofibrous-silk-as-a-physically-transient-chemosensor-and-vitamin-deliverer
#18
Kyungtaek Min, Sookyoung Kim, Chang Gun Kim, Sunghwan Kim
Biodegradable and physically transient optics represent an emerging paradigm in healthcare devices by harnessing optically active system and obviating issues with chronic uses. Light emitting components that can efficiently interact with their environments have advantages of high sensitivity, visibility, and wireless operation. Here, we report a novel combination of silk biopolymer and optically active organic dyes resulting in versatile fluorescent silk nanofibers (FSNs). FSNs generated by the electrospinning method exhibit attractive functions of the doped organic dyes along with programming the system that physically disappear at prescribed time...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28676375/the-family-of-berberine-bridge-enzyme-like-enzymes-a-treasure-trove-of-oxidative-reactions
#19
REVIEW
Bastian Daniel, Barbara Konrad, Marina Toplak, Majd Lahham, Julia Messenlehner, Andreas Winkler, Peter Macheroux
Biological oxidations form the basis of life on earth by utilizing organic compounds as electron donors to drive the generation of metabolic energy carriers, such as ATP. Oxidative reactions are also important for the biosynthesis of complex compounds, i.e. natural products such as alkaloids that provide vital benefits for organisms in all kingdoms of life. The vitamin B2-derived cofactors flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) enable an astonishingly diverse array of oxidative reactions that is based on the versatility of the redox-active isoalloxazine ring...
July 1, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28664691/influence-of-protein-deficient-diet-vitamin-b-sub-2-sub-supplementation-and-physical-training-on-serum-composition-of-polyunsaturated-fatty-acids-pufas-in-rats
#20
Aneta Lewicka, Sławomir Lewicki, Anna Kłos, Bogdan Dębski, Tomasz Kurył, Jerzy Bertrandt
[b]Introduction[/b]. Prolonged shortages of protein in the diet significantly alter the composition and content of polyunsaturated fatty acids (PUFA) in tissues and body fluids. One of nutritional factors which may reduce negative effects of protein malnutrition might be vitamin B[sub]2[/sub] due to its influence on lipids metabolism. [b]Objective. [/b]The aim of the study was to investigate the influence of low protein (LP) diet enriched with vitamin B[sub]2[/sub] on the content and composition of PUFA in the blood serum of rats treated with dosed physical exercise...
May 11, 2017: Annals of Agricultural and Environmental Medicine: AAEM
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