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Vitamin B2

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https://www.readbyqxmd.com/read/28420530/rapid-determination-of-the-various-native-forms-of-vitamin-b6-and-b2-in-cow-s-milk-using-ultra-high-performance-liquid-chromatography
#1
A Schmidt, M G Schreiner, H K Mayer
As the formation of pyridoxal phosphate, the active cofactor of vitamin B6, is dependent on riboflavin 5-phosphate, we propose a fast and simple ultra-high performance liquid chromatography method for the simultaneous determination of the native B6 vitamers pyridoxal, pyridoxine, pyridoxamine, their mono phosphorus esters and 4-pyridoxic acid as well as vitamin B2 as riboflavin and its phosphorus ester riboflavin 5-phosphate in milk. Separation was achieved under 6.0min by reversed-phase and pH gradient elution...
April 9, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28417148/relationship-between-nutritional-factors-and-hip-bone-density-in-individuals-with-chronic-stroke
#2
Samuel K Y Li, Mabel M P Wan, Frankie P L Siu, Susan Chung, Marco Y C Pang
The aim of this study was to investigate the relationship between dietary habits and hip bone health in community-dwelling individuals with chronic stroke. The usual dietary intake of 94 individuals with chronic stroke (30 women, mean age: 59.0 years) was assessed by a 3-day food record within a single week. Dual-energy X-ray absorptiometry was used to measure bone mineral density (BMD) at both hips. The results showed that low hip bone mass was found in 59 and 50 of the participants on the affected and unaffected side, respectively...
April 17, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28415481/modeling-of-drug-release-behavior-of-ph-and-temperature-sensitive-poly-nipaam-co-aac-ipn-hydrogels-using-response-surface-methodology-and-artificial-neural-networks
#3
Sanogo Brahima, Cihangir Boztepe, Asim Kunkul, Mehmet Yuceer
An interpenetrated polymer network (IPN) poly(NIPAAm-co-AAc) hydrogel was synthesized by two polymerization method: emulsion and solution polymerization. The pH- and temperature-sensitive hydrogel was loaded by swelling with riboflavin drug, a B2 vitamin. The release of riboflavin as a function of time has been achieved under different pH and temperature environments. The determination of experimental conditions and the analysis of drug delivery results were achieved using response surface methodology (RSM)...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28414075/vitamin-b2-deficiency-enhances-the-pro-inflammatory-activity-of-adipocyte-consequences-for-insulin-resistance-and-metabolic-syndrome-development
#4
Agnieszka Irena Mazur-Bialy, Ewa Pocheć
AIMS: Adipose tissue is an endocrine organ important for regulation of such physiological processes as energy metabolism or lipids homeostasis. In an obesity state, it participates in the induction of chronic systemic inflammation accompanied by pro-inflammatory cytokines and fatty acid elevation. For this reasons, adipose tissue is involved in, e.g., insulin resistance, type 2 diabetes or hyperlipidemia development. In our previous study, we have shown that riboflavin deficiency induces a pathological pro-inflammatory response of macrophages, the main component of adipose tissue...
April 14, 2017: Life Sciences
https://www.readbyqxmd.com/read/28407967/molecular-characterization-of-an-unauthorized-genetically-modified-bacillus-subtilis-production-strain-identified-in-a-vitamin-b2-feed-additive
#5
Valentina Paracchini, Mauro Petrillo, Ralf Reiting, Alexandre Angers-Loustau, Daniela Wahler, Andrea Stolz, Birgit Schönig, Anastasia Matthies, Joachim Bendiek, Dominik M Meinel, Sven Pecoraro, Ulrich Busch, Alex Patak, Joachim Kreysa, Lutz Grohmann
Many food and feed additives result from fermentation of genetically modified (GM) microorganisms. For vitamin B2 (riboflavin), GM Bacillus subtilis production strains have been developed and are often used. The presence of neither the GM strain nor its recombinant DNA is allowed for fermentation products placed on the EU market as food or feed additive. A vitamin B2 product (80% feed grade) imported from China was analysed. Viable B. subtilis cells were identified and DNAs of two bacterial isolates (LHL and LGL) were subjected to three whole genome sequencing (WGS) runs with different devices (MiSeq, 454 or HiSeq system)...
September 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28406895/the-superfamily-keeps-growing-identification-in-trypanosomatids-of-ribj-the-first-riboflavin-transporter-family-in-protists
#6
Darío E Balcazar, María Cristina Vanrell, Patricia S Romano, Claudio A Pereira, Fernando A Goldbaum, Hernán R Bonomi, Carolina Carrillo
BACKGROUND: Trypanosomatid parasites represent a major health issue affecting hundreds of million people worldwide, with clinical treatments that are partially effective and/or very toxic. They are responsible for serious human and plant diseases including Trypanosoma cruzi (Chagas disease), Trypanosoma brucei (Sleeping sickness), Leishmania spp. (Leishmaniasis), and Phytomonas spp. (phytoparasites). Both, animals and trypanosomatids lack the biosynthetic riboflavin (vitamin B2) pathway, the vital precursor of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) cofactors...
April 13, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28361748/erythrocyte-concentrations-of-b1-b2-b6-but-not-plasma-c-and-e-are-reliable-indicators-of-nutrition-status-in-the-presence-of-systemic-inflammation
#7
Rawia A Ghashut, Donald C McMillan, John Kinsella, Dinesh Talwar
BACKGROUND & AIM: There is increasing evidence that the plasma concentration of vitamin D, carotenoids, zinc and selenium are associated with the magnitude of the systemic inflammatory response. In order to examine whether other vitamins may be affected and whether red cell concentrations are less affected by systemic inflammation the aim of the present study was to examine the effect of the systemic inflammatory response on red cell measurements of vitamins B1, B2 and B6, and plasma concentration of vitamin C and E in a large cohort of patients referred for a nutritional screen...
February 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28327345/immunoassays-for-riboflavin-and-flavin-mononucleotide-using-antibodies-specific-to-d-ribitol-and-d-ribitol-5-phosphate
#8
G Ravi, Yeldur P Venkatesh
Riboflavin (vitamin B2), a water-soluble vitamin, plays a key role in maintaining human health. Though, numerous methods have been reported for the determination of total riboflavin (TRF) content in foods and biological samples, very few methods are reported for quantifying riboflavin and its coenzymes [flavin mononucleotide (FMN); flavin adenine dinucleotide (FAD)] individually. Recently, we have demonstrated that antibodies specific to d-ribitol and d-ribitol-5-phosphate also recognize riboflavin and FMN, respectively, and not vice-versa...
March 18, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28275666/data-representing-two-separate-lc-ms-methods-for-detection-and-quantification-of-water-soluble-and-fat-soluble-vitamins-in-tears-and-blood-serum
#9
Maryam Khaksari, Lynn R Mazzoleni, Chunhai Ruan, Robert T Kennedy, Adrienne R Minerick
Two separate liquid chromatography (LC)-mass spectrometry (MS) methods were developed for determination and quantification of water-soluble and fat-soluble vitamins in human tear and blood serum samples. The water-soluble vitamin method was originally developed to detect vitamins B1, B2, B3 (nicotinamide), B5, B6 (pyridoxine), B7, B9 and B12 while the fat-soluble vitamin method detected vitamins A, D3, 25(OH)D3, E and K1. These methods were then validated with tear and blood serum samples. In this data in brief article, we provide details on the two LC-MS methods development, methods sensitivity, as well as precision and accuracy for determination of vitamins in human tears and blood serum...
April 2017: Data in Brief
https://www.readbyqxmd.com/read/28272391/stabilizing-short-lived-schiff-base-derivatives-of-5-aminouracils-that-activate-mucosal-associated-invariant-t-cells
#10
Jeffrey Y W Mak, Weijun Xu, Robert C Reid, Alexandra J Corbett, Bronwyn S Meehan, Huimeng Wang, Zhenjun Chen, Jamie Rossjohn, James McCluskey, Ligong Liu, David P Fairlie
Mucosal-associated invariant T (MAIT) cells are activated by unstable antigens formed by reactions of 5-amino-6-D-ribitylaminouracil (a vitamin B2 biosynthetic intermediate) with glycolysis metabolites such as methylglyoxal. Here we show superior preparations of antigens in dimethylsulfoxide, avoiding their rapid decomposition in water (t1/2 1.5 h, 37 °C). Antigen solution structures, MAIT cell activation potencies (EC50 3-500 pM), and chemical stabilities are described. Computer analyses of antigen structures reveal stereochemical and energetic influences on MAIT cell activation, enabling design of a water stable synthetic antigen (EC50 2 nM)...
March 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/28263545/investigation-of-the-mesoporous-metal-organic-framework-as-a-new-platform-to-study-the-transport-phenomena-of-biomolecules
#11
Yao Chen, Seongmin Hong, Chung-Wei Fu, Tran Hoang, Xiao Li, Veronica Valencia, Zhenjie Zhang, Jason A Perman, Shengqian Ma
Mesoporous materials, Tb-mesoMOF and MCM-41, were used to study the transport phenomena of biomolecules entering the interior pores from solution. Vitamins B12 and B2 were successfully encapsulated into these mesoporous materials, whereas Tb-mesoMOF (0.33 g of B12/g, 0.01 g of B2/g) adsorbed a higher amount of vitamin per mass than MCM-41 (0.21 g of B12/g, 0.002 g of B2/g). The diffusion mechanism of the biomolecules entering Tb-mesoMOF was evaluated using a mathematical model. The Raman spectroscopy studies showed vitamin B12 has been encapsulated within Tb-mesoMOF's pores, and evaluation of the peak shifts indicated strong interactions linking vitamin B12's pyrroline moiety with Tb-mesoMOF's triazine and benzoate rings...
March 29, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28261556/relationships-between-dietary-intake-and-cognitive-function-in-healthy-korean-children-and-adolescents
#12
Jin Young Kim, Seung Wan Kang
BACKGROUND: It has long been theorized that a relatively robust dietary intake impacts cognitive function. The aim of the study was to explore dietary intake and cognitive function in healthy Korean children and adolescents. METHODS: Three hundred and seventeen healthy children with no previous diagnosis of neurologic or psychiatric disorders were evaluated (167 girls and 150 boys with a mean age of 11.8 ± 3.3 years). Analysis indicators including food frequency questionnaires (FFQs) consisting of 76 items and neurocognitive tests including symbol digit modalities (SDMT), verbal memory, visual memory, shift attention, reasoning, and digit span (forward and backward) tests were observed and recorded...
January 2017: Journal of Lifestyle Medicine
https://www.readbyqxmd.com/read/28257107/micronutrient-fortified%C3%A2-milk%C3%A2-and%C3%A2-academic%C3%A2-performance%C3%A2-among%C3%A2-chinese%C3%A2-middle%C3%A2-school%C3%A2-students-%C3%A2-a%C3%A2-cluster-randomized%C3%A2-controlled%C3%A2-trial
#13
Xiaoqin Wang, Zhaozhao Hui, Xiaoling Dai, Paul D Terry, Yue Zhang, Mei Ma, Mingxu Wang, Fu Deng, Wei Gu, Shuangyan Lei, Ling Li, Mingyue Ma, Bin Zhang
Many children suffer from nutritional deficiencies that may negatively affect their academic performance. This cluster-randomized controlled trial aimed to test the effects of micronutrient-fortified milk in Chinese students. Participants received either micronutrient-fortified (n = 177) or unfortified (n = 183) milk for six months. Academic performance, motivation, and learning strategies were estimated by end-of-term tests and the Motivated Strategies for Learning Questionnaire. Blood samples were analyzed for micronutrients...
March 2, 2017: Nutrients
https://www.readbyqxmd.com/read/28224106/impact-of-high-dose-vitamin-c-on-platelet-function
#14
Bassem M Mohammed, Kimberly W Sanford, Bernard J Fisher, Erika J Martin, Daniel Contaifer, Urszula Osinska Warncke, Dayanjan S Wijesinghe, Charles E Chalfant, Donald F Brophy, Alpha A Fowler Iii, Ramesh Natarajan
AIM: To examine the effect of high doses of vitamin C (VitC) on ex vivo human platelets (PLTs). METHODS: Platelet concentrates collected for therapeutic or prophylactic transfusions were exposed to: (1) normal saline (control); (2) 0.3 mmol/L VitC (Lo VitC); or (3) 3 mmol/L VitC (Hi VitC, final concentrations) and stored appropriately. The VitC additive was preservative-free buffered ascorbic acid in water, pH 5.5 to 7.0, adjusted with sodium bicarbonate and sodium hydroxide...
February 4, 2017: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28213665/neurologic-manifestations-of-vitamin-b-deficiency-after-bariatric-surgery
#15
Suriya Punchai, Zubaidah Nor Hanipah, Katherine M Meister, Philip R Schauer, Stacy A Brethauer, Ali Aminian
INTRODUCTION: The aim of this study was to assess the incidence, clinical presentation, and outcomes of neurologic disorders secondary to vitamin B deficiencies following bariatric surgery. METHODS: Patients at a single academic institution who underwent bariatric surgery and developed neurologic complications secondary to low levels of vitamins B1, B2, B6, and B12 between the years 2004 and 2015 were studied. RESULTS: In total, 47 (0.7%) bariatric surgical patients (Roux-en-Y gastric bypass n = 36, sleeve gastrectomy n = 9, and duodenal switch n = 2) developed neurologic manifestations secondary to vitamin B deficiencies...
February 17, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28212289/the-effects-of-myo-inositol-and-b-and-d-vitamin-supplementation-in-the-db-mouse-model-of-gestational-diabetes-mellitus
#16
Jasmine F Plows, Florence Budin, Rebecka A M Andersson, Valerie J Mills, Katherine Mace, Sandra T Davidge, Mark H Vickers, Philip N Baker, Irma Silva-Zolezzi, Joanna L Stanley
Gestational diabetes mellitus (GDM) is a growing concern, affecting an increasing number of pregnant women worldwide. By predisposing both the affected mothers and children to future disease, GDM contributes to an intergenerational cycle of obesity and diabetes. In order to stop this cycle, safe and effective treatments for GDM are required. This study sought to determine the treatment effects of dietary supplementation with myo-inositol (MI) and vitamins B2, B6, B12, and D in a mouse model of GDM (pregnant db/+ dams)...
February 15, 2017: Nutrients
https://www.readbyqxmd.com/read/28212284/micronutrient-intakes-in-553-dutch-elite-and-sub-elite-athletes-prevalence-of-low-and-high-intakes-in-users-and-non-users-of-nutritional-supplements
#17
Floris Wardenaar, Naomi Brinkmans, Ingrid Ceelen, Bo Van Rooij, Marco Mensink, Renger Witkamp, Jeanne De Vries
This study investigated whether athletes meet micronutrient recommendations and whether the adequacy of their intake is related to the use of dietary supplements, sport nutrition products or a combination. Micronutrient intakes of 553 Dutch (sub-) elite athletes were assessed using web-based 24-h dietary recalls with accompanying nutritional supplement questionnaires. In the majority of both users and non-users of dietary supplements, vitamin D intake was below the estimated average requirement (AR) if supplements were not included in the analysis...
February 15, 2017: Nutrients
https://www.readbyqxmd.com/read/28168179/nutrient-intake-according-to-weight-gain-during-pregnancy-job-status-and-household-income
#18
You-Mi Jung, Mi-Ja Choi
The objective of this study was to investigate the association of nutrient intake and pregnancy outcome mediated by weight gain during pregnancy, job status, and household income. Maternal age, educational level, self-reported pre-pregnancy weights, educational level, and household income were collected from the women at 2 months postpartum. For each offspring, weight at birth, length at birth, and gestational age were collected. Participants were asked to report the frequency of consumption of foods between 28-42 weeks into the pregnancy...
January 2017: Clinical Nutrition Research
https://www.readbyqxmd.com/read/28143737/near-complete-correction-of-profound-metabolomic-impairments-corresponding-to-functional-benefit-in-mps-iiib-mice-after-iv-raav9-hnaglu-gene-delivery
#19
Haiyan Fu, Aaron S Meadows, Tierra Ware, Robert P Mohney, Douglas M McCarty
Mucopolysaccharidosis (MPS) IIIB is a lysosomal storage disease with complex CNS and somatic pathology due to a deficiency in α-N-acetylglucosaminidase (NAGLU). Using global metabolic profiling by mass spectrometry targeting 361 metabolites, this study detected significant decreases in 225 and increases in six metabolites in serum samples from 7-month-old MPS IIIB mice, compared to wild-type (WT) mice. The metabolic disturbances involve virtually all major pathways of amino acid, peptide (58/102), carbohydrate (18/28), lipid (111/139), nucleotide (12/24), energy (2/9), vitamin and cofactor (11/16), and xenobiotic (11/28) metabolism...
March 1, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28116431/-preparation-and-clinical-observation-of-koukuining-granules-in-50-patients-with-recurrent-aphthous-ulcer
#20
Meng-Shan Gao, Shuai Liu, Ai-Wu Wang
PURPOSE: To prepare Koukuining granules and observe its efficiency in the treatment of recurrent aphthas ulce (RAU). METHODS: In accordance with the theories of traditional Chinese medicine, the prescriptions of Koukuining granules were composed of rhizoma coptidis, radix scutellariae and other Chinese herbs, and the preparation procedure was conducted by means of wet granulation technology. One hundred patients with RAU were randomly divided into experimental group and control group equally...
October 2016: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
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