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Vitamin B2

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https://www.readbyqxmd.com/read/28073944/a-novel-bifunctional-transcriptional-regulator-of-riboflavin-metabolism-in-archaea
#1
Irina A Rodionova, Matthew W Vetting, Xiaoqing Li, Steven C Almo, Andrei L Osterman, Dmitry A Rodionov
Riboflavin (vitamin B2) is the precursor of flavin mononucleotide (FMN) and flavin adenine dinucleotide, which are essential coenzymes in all free-living organisms. Riboflavin biosynthesis in many Bacteria but not in Archaea is controlled by FMN-responsive riboswitches. We identified a novel bifunctional riboflavin kinase/regulator (RbkR), which controls riboflavin biosynthesis and transport genes in major lineages of Crenarchaeota, Euryarchaeota and Thaumarchaeota. RbkR proteins are composed of the riboflavin kinase domain and a DNA-binding winged helix-turn-helix-like domain...
January 9, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28056273/-study-on-the-contribution-rate-of-follow-up-formula-to-the-nutrient-intake-of-infants-and-young-children-aged-7-24-months-in-china
#2
H Z Li, H X Jia, D Liang, T T Deng, L T Niu, J H Han
Objective: To determine the contribution of follow-up formula (FUF) to the nutrient intake of 7-24-month-old infants and young children. Methods: The cluster random sampling method and the convenience sampling method were used in combination, and geographic and economic factors were taken into consideration. Four areas of China (Beijing, Hebei, Guangxi, Guangdong) were selected, with 120 infants chosen from each of these areas (half of which were 7-12 months old, and half were 13-24 months old). A dietary survey was completed by a continuous 24-hour weighing method over two days...
January 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28035488/dietary-vitamin-b2-intake-and-breast-cancer-risk-a-systematic-review-and-meta-analysis
#3
Lanting Yu, Yuyan Tan, Lin Zhu
BACKGROUND: Epidemiological studies assessing the relationship between dietary vitamin B2 and the risk of breast cancer have produced inconsistent results. Thus, we conducted this meta-analysis of epidemiologic studies to evaluate this association. METHODS: We searched English-language MEDLINE publications and conducted a manual search to screen eligible articles. A random-effect model was used to pool study-specific risk estimates. Egger's linear regression test was also used to detect publication bias in meta-analysis...
December 29, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28025000/determination-of-water-soluble-and-fat-soluble-vitamins-in-tears-and-blood-serum-of-infants-and-parents-by-liquid-chromatography-mass-spectrometry
#4
Maryam Khaksari, Lynn R Mazzoleni, Chunhai Ruan, Robert T Kennedy, Adrienne R Minerick
Tears serve as a viable diagnostic fluid with advantages including less invasive sample to collect and less complex to prepare for analysis. Several water-soluble and fat-soluble vitamins were detected and quantified in human tears and compared with blood serum levels. Samples from 15 family pairs, each pair consisting of a four-month-old infant and one parent were analyzed; vitamin concentrations were compared between tears and blood serum for individual subjects, between infants and parents, and against self-reported dietary intakes...
December 23, 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/27990293/vitamin-levels-in-adults-with-adhd
#5
Elisabeth Toverud Landaas, Tore Ivar Malmei Aarsland, Arve Ulvik, Anne Halmøy, Per Magne Ueland, Jan Haavik
BACKGROUND: Micronutrients containing vitamins are reported to reduce symptom levels in persons with attention-deficit hyperactivity disorder (ADHD), but data on vitamin levels in ADHD are sparse. AIMS: To examine the relationship between vitamin concentrations, ADHD diagnosis and psychiatric symptoms in young adult ADHD patients and controls. METHOD: Eight vitamins and the nicotine metabolite cotinine were analysed in serum samples from 133 ADHD patients and 131 controls aged between 18 and 40, who also reported ADHD symptoms and comorbid conditions...
November 2016: BJPsych Open
https://www.readbyqxmd.com/read/27983705/riboflavin-reduces-pro-inflammatory-activation-of-adipocyte-macrophage-co-culture-potential-application-of-vitamin-b2-enrichment-for-attenuation-of-insulin-resistance-and-metabolic-syndrome-development
#6
Agnieszka Irena Mazur-Bialy, Ewa Pocheć
Due to the progressive increase in the incidence of obese and overweight individuals, cardiometabolic syndrome has become a worldwide pandemic in recent years. Given the immunomodulatory properties of riboflavin, the current study was performed to investigate the potency of riboflavin in reducing obesity-related inflammation, which is the main cause of insulin resistance, diabetes mellitus 2 or arteriosclerosis. We determined whether pretreatment with a low dose of riboflavin (10.4-1000 nM) affected the pro-inflammatory activity of adipocyte-macrophage co-culture (3T3 L1-RAW 264...
December 15, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27966212/factors-stimulating-riboflavin-produced-by-lactobacillus-plantarum-crl-725-grown-in-a-semi-defined-medium
#7
Marianela Juarez Del Valle, Jonathan Emiliano Laiño, Graciela Savoy de Giori, Jean Guy LeBlanc
Riboflavin (vitamin B2 ) is one of the B-group water-soluble vitamins and is essential for energy metabolism of the cell. The aim of this study was to determine factors that affect riboflavin production by Lactobacillus (L.) plantarum CRL 725 grown in a semi defined medium and evaluate the expression of its rib genes. The factors found to enhance riboflavin production in this medium were incubation at 30 °C, and the addition of specific medium constituents, such as casamino acids (10 g L(-1) ), guanosine (0...
December 14, 2016: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/27964953/blood-to-retina-transport-of-riboflavin-via-rfvts-at-the-inner-blood-retinal-barrier
#8
Yoshiyuki Kubo, Shizuka Yahata, Satoshi Miki, Shin-Ichi Akanuma, Ken-Ichi Hosoya
Riboflavin (vitamin B2) supply to the retina across the inner blood-retinal barrier (BRB) was investigated. In rats, the apparent influx permeability clearance of [(3)H]riboflavin (62.8 μL/(min·g retina)) was much higher than that of a non-permeable paracellular marker, suggesting the facilitative influx transport of riboflavin across the BRB. The retinal uptake index (RUI) of [(3)H]riboflavin was 59.0%, and significantly reduced by flavin adenine dinucleotide (FAD), but not by l-ascorbic acid, suggesting the substrate specificity of riboflavin transport...
October 8, 2016: Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/27889885/investigating-factors-involved-in-post-laparoscopic-sleeve-gastrectomy-lsg-neuropathy
#9
Almaha Alsabah, Salman Al Sabah, Suleiman Al-Sabah, Ahmad Al-Serri, Eliana Al Haddad, Waleed M Renno
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) has gained popularity as the leading bariatric procedure for the treatment of morbid obesity. Due to the rising numbers of bariatric surgeries, neurologic complications have become increasingly recognized. Our aim was to examine biochemical and hormonal factors that are associated with neuropathy post-LSG. METHODS: Thirty-two patients were included: 16 patients with neuropathy in the neuropathic group (NG) and 16 patients without neuropathy in the control group (CG)...
November 26, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27886772/selective-and-sensitive-electrochemical-device-for-direct-vb2-determination-in-real-products
#10
Agata Kowalczyk, Monika Sadowska, Beata Krasnodebska-Ostrega, Anna M Nowicka
The developed by us electrochemical device for vitamin B2 (VB2; riboflavin) determination, without preconcentration step, in real products exhibits high sensitivity, selectivity, stability and low detection limit compared to those described in the literature. The determination procedure was based on the monitoring of the reduction current signal of VB2 bound with dsDNA anchored to the electrode surface through intermediary - carboxyphenyl layer. The application of such intermediary layer formed during electroreduction of appropriate diazonium salt at CV peak potential guarantees high efficiency of hybridization process and thus fully available places for VB2 interaction...
January 15, 2017: Talanta
https://www.readbyqxmd.com/read/27886045/nutrition-one-carbon-metabolism-and-neural-tube-defects-a-review
#11
REVIEW
Kelei Li, Mark L Wahlqvist, Duo Li
Neural tube defects (NTDs) are a group of severe congenital malformations, induced by the combined effects of genes and the environment. The most valuable finding so far has been the protective effect of folic acid supplementation against NTDs. However, many women do not take folic acid supplements until they are pregnant, which is too late to prevent NTDs effectively. Long-term intake of folic acid-fortified food is a good choice to solve this problem, and mandatory folic acid fortification should be further promoted, especially in Europe, Asia and Africa...
November 23, 2016: Nutrients
https://www.readbyqxmd.com/read/27866467/vitamin-d2-ergosterol-and-vitamin-b2-content-in-commercially-dried-mushrooms-marketed-in-china-and-increased-vitamin-d2-content-following-uv-c-irradiation
#12
Guocheng Huang, Weixi Cai, Baojun Xu
Mushrooms are a great source of vitamin D and vitamin B2; however, the content of these vitamins in dried mushrooms has not fully been investigated. Thus, the objectives of this study were to determine the contents of vitamin D2, ergosterol, and vitamin B2 in commercially dried edible mushrooms in China and to investigate the effect of UV-C irradiation on fresh mushrooms. Among the 35 species of dried mushrooms considered for this study, the average ergosterol content was 1.98 mg/g, while the average vitamin D2 content was 16...
November 21, 2016: International Journal for Vitamin and Nutrition Research. Journal International de Vitaminologie et de Nutrition
https://www.readbyqxmd.com/read/27866256/surfactant-free-microemulsion-electrokinetic-chromatography-sf-meekc-with-uv-and-ms-detection-a-novel-approach-for-the-separation-and-esi-ms-detection-of-neutral-compounds
#13
Urška Mohorič, Andrea Beutner, Sebastian Krickl, Didier Touraud, Werner Kunz, Frank-Michael Matysik
Microemulsion electrokinetic chromatography (MEEKC) is a powerful tool to separate neutral species based on differences in their hydrophobic and hydrophilic properties. However, as a major drawback the conventionally used SDS based microemulsions are not compatible with electrospray ionization mass spectrometry (ESI-MS). In this work, a surfactant-free microemulsion (SFME) consisting of water, ethanol, and 1-octanol is used for surfactant-free microemulsion electrokinetic chromatography (SF-MEEKC). Ammonium acetate was added to the SFME enabling electrophoretic separations...
December 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27825397/micronutrient-intake-in-advanced-age-te-pu%C3%A4-waitanga-o-ng%C3%A4-tapuwae-kia-ora-tonu-life-and-living-in-advanced-age-a-cohort-study-in-new-zealand-lilacs-nz
#14
Carol Wham, Ruth Teh, Simon A Moyes, Anna Rolleston, Marama Muru-Lanning, Karen Hayman, Ngaire Kerse, Ashley Adamson
A high prevalence of undernutrition has previously been reported in indigenous Māori (49 %) and non-Māori (38 %) octogenarians and may be associated with risk of micronutrient deficiencies. We examined vitamin and mineral intakes and the contributing food sources among 216 Māori and 362 non-Māori participating in Life and Living to Advanced age a Cohort Study in New Zealand, using a repeat 24-h multiple-pass recall. More than half of the Māori and non-Māori participants had intakes below the estimated average requirement from food alone for Ca, Mg and Se...
November 9, 2016: British Journal of Nutrition
https://www.readbyqxmd.com/read/27819022/dietary-energy-density-renal-function-and-progression-of-chronic-kidney-disease
#15
Mohammad Hossein Rouhani, Mojgan Mortazavi Najafabadi, Ahmad Esmaillzadeh, Awat Feizi, Leila Azadbakht
Background. There is evidence of the association between dietary energy density and chronic diseases. However, no report exists regarding the relation between DED and chronic kidney disease (CKD). Objective. To examine the association between dietary energy density (DED), renal function, and progression of chronic kidney disease (CKD). Design. Cross-sectional. Setting. Three nephrology clinics. Subjects. Two hundred twenty-one subjects with diagnosed CKD. Main Outcome Measure. Dietary intake of patients was assessed by a validated food frequency questionnaire...
2016: Advances in Medicine
https://www.readbyqxmd.com/read/27812289/concentrations-of-water-soluble-vitamins-in-blood-and-urinary-excretion-in-patients-with-diabetes-mellitus
#16
Hiromi Iwakawa, Yasuyuki Nakamura, Tomiho Fukui, Tsutomu Fukuwatari, Satoshi Ugi, Hiroshi Maegawa, Yukio Doi, Katsumi Shibata
We examined the concentrations of water-soluble vitamins in blood and urinary excretion of 22 patients with type 2 diabetes mellitus (type 2DM) and 20 healthy control participants. Macronutrient and vitamin intakes of type 2DM subjects were measured using a weighed food record method. Control participants consumed a semipurified diet for eight days. Multiple linear regression models were used to determine whether significant differences existed in vitamin concentrations in blood independent of age, sex, and other confounding factors...
2016: Nutrition and Metabolic Insights
https://www.readbyqxmd.com/read/27799239/effectiveness-of-complementary-food-supplements-and-dietary-counselling-on-anaemia-and-stunting-in-children-aged-6-23-months-in-poor-areas-of-qinghai-province-china-a-controlled-interventional-study
#17
Yanfeng Zhang, Qiong Wu, Wei Wang, Michelle Helena van Velthoven, Suying Chang, Huijun Han, Min Xing, Li Chen, Robert W Scherpbier
OBJECTIVE: To assess the effectiveness of dietary counselling and complementary food supplements on anaemia and stunting prevalence in children aged 6-23 months. DESIGN: A controlled intervention study with measurements of height and haemoglobin levels, and cross-sectional surveys in August 2012 (baseline), 2013 (mid-term) and 2014 (end-line). SETTING: One intervention county and one control county in rural Qinghai Province, China. INTERVENTION: Complementary food supplements (containing protein, fat, carbohydrate, vitamin A, B1, B2, B12, D3, folic acid, iron, zinc and calcium) and complementary feeding counselling were given in the intervention county...
October 31, 2016: BMJ Open
https://www.readbyqxmd.com/read/27799085/atheroprotective-effects-of-pure-tocotrienol-supplementation-in-the-treatment-of-rabbits-with-experimentally-induced-early-and-established-atherosclerosis
#18
Thuhairah Abdul Rahman, Noor Faezah Hassim, Nurmazni Zulkafli, Suhaila Muid, Noor Kaslina Kornain, Hapizah Nawawi
BACKGROUND: Atherosclerosis is the main cause of coronary artery disease -related deaths worldwide. The atheroprotective properties of pure tocotrienols (T3) in the absence of alpha-tocopherol (α-TCP) in vitamin E has not been extensively examined. AIM: To determine the atheroprotective properties of T3 in early and established atherosclerosis rabbits. METHODS: Thirty New Zealand white rabbits were divided into two groups, B1 and B2 which represent early [fed 1% high cholesterol diet (HCD) for 2 weeks] and established (fed 1% HCD for 8 weeks) atherosclerosis...
2016: Food & Nutrition Research
https://www.readbyqxmd.com/read/27738876/colorimetry-as-quality-control-tool-for-individual-inkjet-printed-pediatric-formulations
#19
Henrika Wickström, Johan O Nyman, Mathias Indola, Heidi Sundelin, Leif Kronberg, Maren Preis, Jukka Rantanen, Niklas Sandler
Printing technologies were recently introduced to the pharmaceutical field for manufacturing of drug delivery systems. Printing allows on demand manufacturing of flexible pharmaceutical doses in a personalized manner, which is critical for a successful and safe treatment of patient populations with specific needs, such as children and the elderly, and patients facing multimorbidity. Printing of pharmaceuticals as technique generates new demands on the quality control procedures. For example, rapid quality control is needed as the printing can be done on demand and at the point of care...
October 13, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27726828/skin-findings-associated-with-nutritional-deficiencies
#20
Fabrizio Galimberti, Natasha Atanaskova Mesinkovska
Certain vitamin and mineral deficiencies may be recognized by their cutaneous signs. This case-based article reviews deficiencies of zinc and vitamins A, B2, B3, B6, and C, discussing their consequences and skin findings.
October 2016: Cleveland Clinic Journal of Medicine
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