Alicia Moreno-Sabater, Delphine Sterlin, Lejla Imamovic, Fabienne Bon, Anne-Cecile Normand, Cecile Gonnin, Marianne Gazzano, Merieme Bensalah, Karim Dorgham, Elyes Ben Salah, Aniss Acherar, Christophe Parizot, Virginie Rigourd, Hervé Begue, Frederic Dalle, Claude Bachmeyer, Christophe Hennequin, Hans Yssel, Marion Malphettes, Claire Fieschi, Jehane Fadlallah, Guy Gorochov
BACKGROUND: Secretory IgA interacts with commensal bacteria, but its impact on human mycobiota ecology has not been widely explored. In particular, whether human IgA-deficiency is associated with gut fungal dysbiosis remains unknown. OBJECTIVES: Our goal was to study the impact of IgA on gut mycobiota ecology. METHODS: The Fungi-Flow method was used to characterize fecal, systemic, and maternal IgA, IgM, and IgG responses against 14 representative fungal strains (yeast/spores or hyphae forms) in healthy donors (HDs) (n = 34, 31, and 20, respectively) and to also compare gut mycobiota opsonization by secretory antibodies in HDs (n = 28) and patients with selective IgA deficiency (SIgAd) (n = 12)...
September 2023: Journal of Allergy and Clinical Immunology