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Candida albicans IgA

Ghaffari Javad, Mehdi Taheri Sarvtin, Mohammad Taghi Hedayati, Zohreh Hajheydari, Jamshid Yazdani, Tahereh Shokohi
The aim of this study was to assess the candidal colonization and specific humoral responses against Candida albicans in patients with atopic dermatitis. One hundred patients with atopic dermatitis and 50 healthy individuals were enrolled in the study. Skin and oral specimens from all participants were cultured on CHROMagar Candida medium. Isolated yeasts were identified by using the sequence of the D1/D2 domain of the 26S rRNA gene. ELISA was used for detection of IgM, IgA, and IgG antibodies against C. albicans in sera of participants...
2015: BioMed Research International
Marion Corouge, Séverine Loridant, Chantal Fradin, Julia Salleron, Sébastien Damiens, Maria Dolores Moragues, Vianney Souplet, Thierry Jouault, Raymond Robert, Sylvain Dubucquoi, Boualem Sendid, Jean Fréderic Colombel, Daniel Poulain
OBJECTIVE: The protein Hwp1, expressed on the pathogenic phase of Candida albicans, presents sequence analogy with the gluten protein gliadin and is also a substrate for transglutaminase. This had led to the suggestion that C. albicans infection (CI) may be a triggering factor for Celiac disease (CeD) onset. We investigated cross-immune reactivity between CeD and CI. METHODS: Serum IgG levels against recombinant Hwp1 and serological markers of CeD were measured in 87 CeD patients, 41 CI patients, and 98 healthy controls (HC)...
2015: PloS One
Bela Mahajan, Neeta Bagul, Rajiv Desai, Mamatha Reddy, Amit Mahajan, Ashwini Shete, Arun Risbud, Arati Mane
Saliva plays an important role in maintaining microbial homeostasis in the oral cavity, while salivary gland hypofunction predisposes the oral mucosa to pathologic alteration and increases the risk for oral candidiasis. This study sought to determine the salivary flow rate (SFR) and secretory immunoglobulin A (SIgA) levels in HIV-positive and HIV-negative individuals and evaluate their relationship with the determinants of oral candidiasis. Sixty HIV-positive (30 with and 30 without oral candidiasis) and 30 healthy HIV-negative individuals were enrolled...
August 2015: Mycopathologia
Ema Paulovičová, Helena Bujdáková, Jarmila Chupáčová, Lucia Paulovičová, Pavol Kertys, Martin Hrubiško
In vitro evaluation of specific anti-Candida albicans sera antibodies based on synthetically prepared complement receptor 3-related protein (CR3-RP) mimicking the structure of native complement receptor 3 in a cohort of 72 patients with atopy and recurrent Candida vulvovaginitis (RVC) revealed effective humoral response against Candida CR3-RP. The most significant have been IgM and IgA isotype antibodies (33 and 47% positive cases, respectively). The quantitative evaluation of anti-CR3RP isotype antibodies was confronted with results of commercial ELISA anti-C...
March 2015: FEMS Yeast Research
M Suchankova, E Paulovicova, L Paulovicova, I Majer, E Tedlova, H Novosadova, E Tibenska, M Tedla, M Bucova
The recent studies suggest a role of fungi in development of sarcoidosis. Moreover, the immune response in sarcoidosis and fungal infection shows a striking similarity. We formulated a hypothesis of the possible increase in antifungal antibodies in bronchoalveolar lavage fluid (BALF) and serum in pulmonary sarcoidosis. BALF and serum levels of IgG-, IgM- and IgA-specific antibodies against the cell wall β-D-glucan and mannan of Candida albicans and Saccharomyces cerevisiae were tested in 47 patients (29 pulmonary sarcoidosis patients and 18 patients with other interstitial lung diseases (ILD - control group)) and 170 healthy controls...
April 2015: Scandinavian Journal of Immunology
Mehdi Taheri Sarvtin, Tahereh Shokohi, Zohreh Hajheydari, Jamshid Yazdani, Mohammad T Hedayati
BACKGROUND: Psoriasis is an inflammatory skin disease that can considerably affect a patient's quality of life. Environmental and genetic factors, as well as superantigens and toxins from Candida species, may play various roles in the exacerbation and persistence of psoriasis. In the present study, we evaluated candidal colonization and specific humoral responses against Candida albicans in patients with psoriasis. METHODS: A total of 100 patients with psoriasis vulgaris and 50 healthy control individuals were enrolled in the study...
December 2014: International Journal of Dermatology
O V Voĭtovych, O M Kamyshnyĭ
Possible influence of man-made load on formation and function of microbiocenosis of the nose mucosa in practically healthy people of industrial city has been studied. Microbiota composition, content of secretory immunoglobulin A, functional state and expression of TLR-2 and TLR-4 by mucosa cells were studied in the given human biotope. The residing in conventionally contaminated districts of the industrial city tells on the increase of ecologic role of Candida albicans in the composition of microbiocenosis of the nose mucosa...
March 2014: Mikrobiolohichnyĭ Zhurnal., Mikrobiologichny Zhurnal
Célia Regina Gonçalves e Silva, Luciane Dias de Oliveira, Mariella Vieira Pereira Leão, Antonio Olavo Cardoso Jorge
Adhesion and colonization of the oral cavity by Candida albicans is an initial step in candidosis. Orthodontic and other oral appliances seem to favor candidal presence. The aim of this work was to compare the presence of Candida species in saliva, their adherence to oral epithelial cells, and the levels of anti–C. albicans IgA in children with or without orthodontic appliances. This study included 30 children 5 to 12 years old (9.1 ± 1.7 years old) who were users of removable orthodontic devices for at least 6 months and 30 control children of similar ages (7...
2014: Brazilian Oral Research
Ashraf S Ibrahim, Guanpingsheng Luo, Teclegiorgis Gebremariam, Hongkyu Lee, Clint S Schmidt, John P Hennessey, Samuel W French, Michael R Yeaman, Scott G Filler, John E Edwards
We have previously reported that vaccination with rAls3p-N protein of Candida albicans, formulated with alum adjuvant (also designated as NDV-3) protects immunocompetent mice from, lethal disseminated candidiasis and mucosal oropharyngeal candidiasis. NDV-3 vaccine was recently, tested in a Phase 1 clinical trial and found to be safe, well-tolerated, and induced robust humoral and, cellular immune responses with increased interferon (IFN)-gamma and interleukin (IL)-17 secretion. In preparation for a Phase 2 clinical trial against vulvovaginal candidiasis (VVC), we evaluated NDV-3, efficacy in a murine VVC model...
November 12, 2013: Vaccine
Agda Lima Dos Santos, Antônio Olavo Cardoso Jorge, Silvana Soléo Ferreira Dos Santos, Célia Regina Gonçalves E Silva, Mariella Vieira Pereira Leão
Probiotics are defined as microorganisms that promote benefits to host health, mainly by regulating resident microbiota. Disequilibrium in microbiota can favor the growth of opportunist microorganisms and the development of pathologies, like candidosis caused by yeasts of the Candida genus. This work evaluated whether probiotics consumption was able to influence a specific immunological response to Candida and the presence of these yeasts in the oral cavity. Saliva samples were collected from healthy individuals and plated in Dextrose Saboraud Agar with chloramphenicol...
October 2009: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
Imen Amouri, Inès Hadrich, Salma Abbes, Hayet Sellami, Ali Ayadi
Recurrent vulvo-vaginal candidiasis (RVVC) is a significant problem facing women of child bearing age. It is now accepted that RVVC is the consequence of local immunodeficiency. The aim of this study was to assess differential secretion of IgAs and IgG anti-C. albicans in vaginal secretions of patients with RVVC, VVC and asymptomatic women. Vaginal secretions collected from 3 groups of women: 14 patients with RVVC, 8 patients with VVC and 17 asymptomatic women. Overall analysis of vaginal secretions revealed that the prevalence of IgAs (73%) and IgG (33%) antibodies anti-C...
March 2013: Annales de Biologie Clinique
Fabio Henrique Boarini Pacheco Mendonça, Silvana Soléo Ferreira dos Santos, Ivan da Silva de Faria, Célia Regina Gonçalves e Silva, Antônio Olavo Cardoso Jorge, Mariella Vieira Pereira Leão
Imbalance in the resident microbiota may promote the growth of opportunistic microorganisms, such as yeasts of Candida genus and the development of diseases, especially in aged people. This study evaluated whether the consumption of the probiotic Yakult LBz(®) (Lactobacillus casei and Bifidobacterium breve) was able to influence on the specific immunological response against Candida and on the presence of these yeasts in the oral cavity of 42 healthy aged individuals. Saliva samples were collected before and after the probiotic use for 30 days, 3 times a week...
2012: Brazilian Dental Journal
Emma Lindh, Johan Brännström, Petra Jones, Fredrik Wermeling, Signe Hässler, Corrado Betterle, Ben Zion Garty, Mats Stridsberg, Björn Herrmann, Mikael C I Karlsson, Ola Winqvist
Patients with the monogenic disease autoimmune polyendocrine syndrome type I (APSI) develop autoimmunity against multiple endocrine organs and suffer from chronic mucocutaneous candidiasis (CMC), a paradoxical complication with an unknown mechanism. We report here that saliva from APSI patients with CMC is defective in inhibiting growth of Candida albicans in vitro and show reduced levels of a salivary protein identified as cystatin SA1. In contrast, APSI patients without CMC express salivary cystatin SA1 and can inhibit C...
May 2013: Journal of Autoimmunity
Clint S Schmidt, C Jo White, Ashraf S Ibrahim, Scott G Filler, Yue Fu, Michael R Yeaman, John E Edwards, John P Hennessey
The investigational vaccine, NDV-3, contains the N-terminal portion of the Candida albicans agglutinin-like sequence 3 protein (Als3p) formulated with an aluminum hydroxide adjuvant in phosphate-buffered saline. Preclinical studies demonstrated that the Als3p vaccine antigen protects mice from oropharyngeal, vaginal and intravenous challenge with C. albicans and other selected species of Candida as well as both intravenous challenge and skin and soft tissue infection with Staphylococcus aureus. The objectives of this first-in-human Phase I clinical trial were to evaluate the safety, tolerability and immunogenicity of NDV-3 at two different antigen levels compared to a saline placebo...
December 14, 2012: Vaccine
Norihiko Kanaguchi, Naoki Narisawa, Tatsuro Ito, Yosuke Kinoshita, Yasuka Kusumoto, Osamu Shinozuka, Hidenobu Senpuku
BACKGROUND: Candida albicans is a dimorphic fungus that is part of the commensal microbial flora of the oral cavity. When the host immune defenses are impaired or when the normal microbial flora is disturbed, C. albicans triggers recurrent infections of the oral mucosa and tongue. Recently, we produced NOD/SCID.e2f1-/- mice that show hyposalivation, decrease of salivary protein flow, lack IgA and IgG in saliva, and have decreased NK cells. Our objective was to characterize C. albicans infection and biofilm formation in mice...
2012: BMC Oral Health
Martin P Reichhardt, Vuokko Loimaranta, Steffen Thiel, Jukka Finne, Seppo Meri, Hanna Jarva
The salivary scavenger and agglutinin (SALSA), also known as gp340, salivary agglutinin and deleted in malignant brain tumor 1, is a 340-kDa glycoprotein expressed on mucosal surfaces and secreted into several body fluids. SALSA binds to a broad variety of microbes and endogenous ligands, such as complement factor C1q, surfactant proteins D and A, and IgA. Our search for novel ligands of SALSA by direct protein-interaction studies led to the identification of mannan-binding lectin (MBL) as a new binding partner...
2012: Frontiers in Immunology
Flavia De Bernardis, Mario Amacker, Silvia Arancia, Silvia Sandini, Christel Gremion, Rinaldo Zurbriggen, Christian Moser, Antonio Cassone
A novel vaccine (PEV7) consisting of a truncated, recombinant aspartyl proteinase-2 of Candida albicans incorporated into influenza virosomes was studied. This vaccine candidate generated a potent serum antibody response in mouse and rat following intramuscular immunization. Anti-Sap2 IgG and IgA were also detected in the vaginal fluid of rats following intravaginal or intramuscular plus intravaginal administration. In a rat model of candidal vaginitis, PEV7 induced significant, long-lasting, likely antibody-mediated, protection following intravaginal route of immunization...
June 22, 2012: Vaccine
Luciano Polonelli, Tecla Ciociola, Walter Magliani, Pier Paolo Zanello, Tiziana D'Adda, Serena Galati, Flavia De Bernardis, Silvia Arancia, Elena Gabrielli, Eva Pericolini, Anna Vecchiarelli, Denise C Arruda, Marcia R Pinto, Luiz R Travassos, Thelma A Pertinhez, Alberto Spisni, Stefania Conti
Synthetic peptides with sequences identical to fragments of the constant region of different classes (IgG, IgM, IgA) of antibodies (Fc-peptides) exerted a fungicidal activity in vitro against pathogenic yeasts, such as Candida albicans, Candida glabrata, Cryptococcus neoformans, and Malassezia furfur, including caspofungin and triazole resistant strains. Alanine-substituted derivatives of fungicidal Fc-peptides, tested to evaluate the critical role of each residue, displayed unaltered, increased or decreased candidacidal activity in vitro...
2012: PloS One
Asuka Tanioka, Kazumi Hayama, Masayasu Mitsuya, Shigeru Tansho, Yasuo Ono, Kazufumi Tsubaki, Shigeru Abe
UNLABELLED: We examined the effect of the oral administration of β-D-glucan derived from Aureobasidium pullulans ADK-34 (AP-FBG) on Candida albicans or methicillin-resistant Staphylococcus aureus (MRSA) infection in immunosuppressed mice. Mice pretreated with cyclophosphamide (CY) were intraperitoneally administered AP-FBG for 4 days and then infected with 6×10(4) C. albicans cells. In a preliminary experiment, the survival time of the Candida-infected mice treated with AP-FBG was clearly prolonged...
2012: Medical Mycology Journal
Ann R Holmes, Kenneth Chong, Ely Rodrigues, Richard D Cannon, Elizabeth Carpenter, Dean R Ruske, Patrick J D Dawes
OBJECTIVES: Our goals were to determine whether a bovine milk product containing anti-Candida albicans immunoglobulin A antibodies ("immune milk") could reduce the adherence of C albicans to voice prosthesis silicone in vitro, and whether administration of the milk could reduce C albicans colonization and voice prosthesis damage in vivo. METHODS: An in vitro assay of C albicans attachment to silicone was developed with radiolabeled C albicans. A pilot crossover in vivo trial, over 3 periods of 3 months, was also undertaken for 4 patients with voice prostheses, comparing daily administrations of immune milk and a control milk product...
January 2012: Annals of Otology, Rhinology, and Laryngology
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