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https://www.readbyqxmd.com/read/28078828/biomarkers-upon-discontinuation-of-renal-replacement-therapy-predict-60-day-survival-and-renal-recovery-in-critically-ill-patients-with-acute-kidney-injury
#1
Tingting Yang, Si Sun, Yuliang Zhao, Qiang Liu, Mei Han, Liping Lin, Baihai Su, Songmin Huang, Lichuan Yang
Introduction There is no consensus on the specific indications for weaning critically ill patients with acute kidney injury (AKI) off renal replacement therapy (RRT). This study aimed to explore the prognostic value of several biomarkers measured upon discontinuation of RRT for their value in predicting 60-day survival and renal recovery in an effort to add knowledge to the decision-making process regarding RRT withdrawal. Methods We prospectively enrolled 102 patients with AKI who required RRT from the intensive care unit...
January 11, 2017: Hemodialysis International
https://www.readbyqxmd.com/read/28075620/diagnostic-efficacy-of-structural-mri-in-patients-with-mild-to-moderate-alzheimer-disease-automated-volumetric-assessment-versus-visual-assessment
#2
Jeeyoung Min, Won-Jin Moon, Ji Young Jeon, Jin Woo Choi, Yeon-Sil Moon, Seol-Heui Han
OBJECTIVE: The purpose of this study was to compare the diagnostic efficacies of an automated volumetric assessment tool and visual assessment in the evaluation of medial temporal lobar atrophy in mild-to-moderate Alzheimer disease (AD). MATERIALS AND METHODS: This retrospective study included 30 patients with mild-to-moderate AD and 25 age-matched healthy control subjects undergoing MRI with a 3D fast spoiled gradient recalled-echo sequence at 3 T. The images were processed with fully automated volumetric analysis software...
January 11, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28069386/sleep-influences-the-immune-response-and-the-rejection-process-alters-sleep-pattern-evidence-from-a-skin-allograft-model-in-mice
#3
Francieli Silva Ruiz, Monica Levy Andersen, Camila Guindalini, Leandro Pires Araujo, José Daniel Lopes, Sergio Tufik
INTRODUCTION: Sleep generally regulates immune functions in a supportive manner and can affect parameters that are directly involved in the rejection process. STUDY OBJECTIVES: The first objective was to assess whether sleep deprivation (SD) or sleep restriction (SR) affects the allograft rejection process in mice. The second objective was to investigate whether the rejection process itself modulates the sleep pattern of allografted mice. DESIGN: Adult BALB/c and C57BL/6J male mice were used as the donors and recipients, respectively, except for the syngeneic group (ISOTX), which received skin from mice of the same strain (C57BL/6J)...
January 6, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28068086/enhanced-lithium-ion-transport-in-poly-ethylene-glycol-diacrylate-supported-solvate-ionogel-electrolytes-via-chemically-cross-linked-ethylene-oxide-pathways
#4
Anthony J D'Angelo, Matthew J Panzer
Lithium-ion solvate ionic liquids (SILs), consisting of complexed Li(+) cations and a weakly basic anion, represent an emergent class of nonvolatile liquid electrolytes suitable for lithium-based electrochemical energy storage. In this report, solid-state, flexible solvate ionogel electrolytes are synthesized via UV-initiated free radical polymerization/cross-linking of poly(ethylene glycol) diacrylate (PEGDA) in situ within the [Li(G4)][TFSI] electrolyte, which is formed by an equimolar mixture of lithium bis(trifluoromethylsulfonyl)imide (LiTFSI) and tetraglyme (G4)...
January 9, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28065581/nitric-oxide-synthase-inhibitor-aminoguanidine-reduces-intracerebroventricular-colchicine-induced-neurodegeneration-memory-impairments-and-changes-of-systemic-immune-responses-in-rats
#5
Susmita Sil, Tusharkanti Ghosh, Rupsa Ghosh, Pritha Gupta
Intracerebroventricular (i.c.v.) injection of colchicine induces neurodegeneration, memory impairments and changes of some systemic immune responses in rats. Though the role of cox 2 in these colchicine induced changes have been evaluated, the influence of nitric oxide synthase (NOS) remains to be studied. The present study was designed to assess the role of NOS on the i.c.v. colchicine induced neurodegeneration, memory impairments and changes of some systemic immune responses by inhibiting its activity with aminoguanidine...
December 13, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/28060820/proteolytic-origin-of-the-soluble-human-il-6r-in-vivo-and-a-decisive-role-of-n-glycosylation
#6
Steffen Riethmueller, Prasath Somasundaram, Johanna C Ehlers, Chien-Wen Hung, Charlotte M Flynn, Juliane Lokau, Maria Agthe, Stefan Düsterhöft, Yijue Zhu, Joachim Grötzinger, Inken Lorenzen, Tomas Koudelka, Kosuke Yamamoto, Ute Pickhinke, Rielana Wichert, Christoph Becker-Pauly, Marisa Rädisch, Alexander Albrecht, Markus Hessefort, Dominik Stahnke, Carlo Unverzagt, Stefan Rose-John, Andreas Tholey, Christoph Garbers
Signaling of the cytokine interleukin-6 (IL-6) via its soluble IL-6 receptor (sIL-6R) is responsible for the proinflammatory properties of IL-6 and constitutes an attractive therapeutic target, but how the sIL-6R is generated in vivo remains largely unclear. Here, we use liquid chromatography-mass spectrometry to identify an sIL-6R form in human serum that originates from proteolytic cleavage, map its cleavage site between Pro-355 and Val-356, and determine the occupancy of all O- and N-glycosylation sites of the human sIL-6R...
January 2017: PLoS Biology
https://www.readbyqxmd.com/read/28057941/combining-in-situ-lithography-with-3d-printed-solid-immersion-lenses-for-single-quantum-dot-spectroscopy
#7
Marc Sartison, Simone Luca Portalupi, Timo Gissibl, Michael Jetter, Harald Giessen, Peter Michler
In the current study, we report on the deterministic fabrication of solid immersion lenses (SILs) on lithographically pre-selected semiconductor quantum dots (QDs). We demonstrate the combination of state-of-the-art low-temperature in-situ photolithography and femtosecond 3D direct laser writing. Several QDs are pre-selected with a localization accuracy of less than 2 nm with low-temperature lithography and three-dimensional laser writing is then used to deterministically fabricate hemispherical lenses on top of the quantum emitter with a submicrometric precision...
January 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28057317/factors-influencing-emergency-nurses-burnout-during-an-outbreak-of-middle-east-respiratory-syndrome-coronavirus-in-korea
#8
Ji Soo Kim, Jeong Sil Choi
PURPOSE: Emergency department (ED) nurses suffer from persistent stress after experiencing the traumatic event of exposure to Middle East respiratory syndrome coronavirus (MERS-CoV), which can subsequently lead to burnout. This study aimed to assess ED nurses' burnout level during an outbreak of MERS-CoV and to identify influencing factors in order to provide basic information for lowering and preventing the level of burnout. METHODS: Study participants were ED nurses working in eight hospitals designated for treating MERS-CoV-infected patients in Korea...
December 2016: Asian Nursing Research
https://www.readbyqxmd.com/read/28052328/type-dependent-association-between-risk-of-cervical-intraepithelial-neoplasia-and-viral-load-of-oncogenic-human-papillomavirus-types-other-than-types-16-and-18
#9
Long Fu Xi, Mark Schiffman, Yang Ke, James P Hughes, Denise A Galloway, Zhonghu He, Ayaka Hulbert, Rachel L Winer, Laura A Koutsky, Nancy B Kiviat
Studies of the clinical relevance of human papillomavirus (HPV) DNA load have focused mainly on HPV16 and HPV18. Data on other oncogenic types are rare. Study subjects were women enrolled in the Atypical Squamous Cells of Undetermined Significance (ASC-US) and Low-Grade Squamous Intraepithelial Lesion (LSIL) Triage Study who had ≥1 of 11 non-HPV16/18 oncogenic types detected during a 2-year follow-up at 6-month intervals. Viral load measurements were performed on the first type-specific HPV-positive specimens...
January 4, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28039295/third-generation-cd28-4-1bb-chimeric-antigen-receptor-t-cells-for-chemotherapy-relapsed-or-refractory-acute-lymphoblastic-leukaemia-a-non-randomised-open-label-phase-i-trial-protocol
#10
Xiao-Yi Tang, Yao Sun, Ang Zhang, Guo-Liang Hu, Wei Cao, Dan-Hong Wang, Bin Zhang, Hu Chen
INTRODUCTION: There is no curative treatment available for patients with chemotherapy relapsed or refractory CD19+ B cells-derived acute lymphoblastic leukaemia (r/r B-ALL). Although CD19-targeting second-generation (2nd-G) chimeric antigen receptor (CAR)-modified T cells carrying CD28 or 4-1BB domains have demonstrated potency in patients with advanced B-ALL, these 2 signalling domains endow CAR-T cells with different and complementary functional properties. Preclinical results have shown that third-generation (3rd-G) CAR-T cells combining 4-1BB and CD28 signalling domains have superior activation and proliferation capacity compared with 2nd-G CAR-T cells carrying CD28 domain...
December 30, 2016: BMJ Open
https://www.readbyqxmd.com/read/28027695/inhibitory-mechanism-of-the-outer-membrane-growth-of-chronic-subdural-hematomas
#11
Koji Osuka, Yasuo Watanabe, Nobuteru Usuda, Masahiro Aoyama, Kenichiro Iwami, Mikinobu Takeuchi, Takeya Watabe, Masakazu Takayasu
We previously demonstrated that the inflammatory cytokine interleukin-6 (IL-6) activates the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway in fibroblasts within the outer membranes of chronic subdural hematomas (CSDHs), and the activation of this pathway may induce CSDH outer membrane growth. The inhibitory system for this signal transduction pathway is unknown. CSDH fluids were obtained from ten patients during trepanation surgery as the case group, and CSF samples were obtained from seven patients suffering from subarachnoid hemorrhage (SAH) on day 1 as the control group...
December 27, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28027599/long-term-prognosis-of-combined-hepatocellular-carcinoma-cholangiocarcinoma-following-liver-transplantation-and-resection
#12
Dong-Hwan Jung, Shin Hwang, Gi-Won Song, Chul-Soo Ahn, Deok-Bog Moon, Ki-Hun Kim, Tae-Yong Ha, Gil-Chun Park, Seung-Mo Hong, Wan-Jun Kim, Woo-Hyoung Kang, Seok- Hwan Kim, Eun Sil Yu, Sung-Gyu Lee
Combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC) is a rare disease. We investigated the clinicopathological features of cHCC-CC and compared the long-term outcomes following liver transplantation (LT) and hepatic resection (HR). We identified 32 LT patients with cHCC-CC through an institutional database search. HR control group (n=100) was selected through propensity score-matching. The incidence of cHCC-CC among all adult LT cases was 1.0%. Mean patient age was 53.4±6.7 years and 26 patients were male...
December 27, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/28018219/silymarin-protects-mouse-liver-and-kidney-from-thioacetamide-induced-toxicity-by-scavenging-reactive-oxygen-species-and-activating-pi3k-akt-pathway
#13
Shatadal Ghosh, Abhijit Sarkar, Sudip Bhattacharyya, Parames C Sil
Silymarin (SMN) has been shown to possess a wide range of biological and pharmacological effects. Besides, SMN has antioxidant and free radical scavenging activities. Thioacetamide (TAA) is a well-documented liver toxin that requires oxidative bioactivation to elicit its hepatotoxic effect which ultimately modifies amine-lipids and proteins. Our study has been designed in a TAA exposed mouse model to investigate whether SMN could protect TAA-induced oxidative stress mediated hepatic and renal damage. Results suggest that TAA generated reactive oxygen species (ROS), caused oxidative stress and induced apoptosis in the liver and kidney cells via JNK as well as PKC and MAPKs signaling...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28013471/inflammation-and-oxidation-do-they-improve-after-kidney-transplantation-relationship-with-mortality-after-transplantation
#14
Laura Cañas, Eva Iglesias, María Cruz Pastor, Jaume Barallat, Javier Juega, Ioana Bancu, Ricardo Lauzurica
: Patients with chronic kidney disease (CKD) are characterized by a state of inflammation and oxidative stress that seems to improve after kidney transplantation (KT). Nevertheless, there is controversy regarding what is the best marker that better define inflammation and specially oxidative stress. OBJECTIVE: To evaluate the biomarkers which are associated with improvements in inflammation and lipid peroxidation in patients who have undergone KT. To evaluate the relationship between inflammation, lipid peroxidation and mortality in KT...
December 24, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/28012047/the-protective-mechanism-of-qgc-in-feline-esophageal-epithelial-cells-by-interleukin-1%C3%AE-treatment
#15
Hyun Soo Jang, Seung In Um, Sung Hee Lee, Wan Kyunn Whang, Young Sil Min, Sun Young Park, Uy Dong Sohn
In a previous study, Quercetin-3-O-β-D-glucuronopyranoside (QGC) has anti-oxidative and anti-inflammatory effects in vivo. QGC is a flavonoid glucoside extracted from Rumex Aquaticus. We investigated the downstream target proteins involved in IL-1β-stimulated ROS production and the ability of QGC to inhibit ROS production. Cell viability was determined using the MTT reduction assay. Western blot analysis was performed with antibodies to investigate the activation of three MAPKs, NF-κB, and phosphorylated IκB-α (pIB), and the expression of COX-2...
December 23, 2016: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28012031/first-200-consecutive-transumbilical-single-incision-laparoscopic-teps
#16
G Dapri, L Gerard, M Paesmans, G-B Cadière, S Saussez
BACKGROUND: Endoscopic pre-peritoneal mesh repair (TEP) through single-incision laparoscopy (SIL) permits placement of a large mesh through a final millimetric umbilical scar. This prospective study evaluates the first 200 consecutive SILTEPs performed by a single surgeon. PATIENTS AND METHODS: Between November 2011 and September 2015, 200 consecutive SILTEPs were performed in 161 patients. The mean age was 49.8 ± 16.3 years and the mean BMI was 24.5 ± 3...
December 23, 2016: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28004799/controlled-orientation-of-active-sites-in-a-nanostructured-multienzyme-complex
#17
Sung In Lim, Byungseop Yang, Younghan Jung, Jaehyun Cha, Jinhwan Cho, Eun-Sil Choi, Yong Hwan Kim, Inchan Kwon
Multistep cascade reactions in nature maximize reaction efficiency by co-assembling related enzymes. Such organization facilitates the processing of intermediates by downstream enzymes. Previously, the studies on multienzyme nanocomplexes assembled on DNA scaffolds demonstrated that closer interenzyme distance enhances the overall reaction efficiency. However, it remains unknown how the active site orientation controlled at nanoscale can have an effect on multienzyme reaction. Here, we show that controlled alignment of active sites promotes the multienzyme reaction efficiency...
December 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28004510/mothers-intentions-to-vaccinate-their-teenaged-children-against-human-papillomavirus-as-predicted-by-sex-in-south-korea-an-application-of-the-theory-of-planned-behavior
#18
Kyung Mi Kim, Jeong Sil Choi
AIM: This study was conducted in order to examine the intention of mothers to vaccinate their teenaged children against human papillomavirus (HPV) infection, according to the children's sex. Based on the theory of planned behavior, the study identified the sex-specific predictors of mothers' intention to vaccinate their teenaged children against HPV. METHODS: This was a descriptive survey study that included, as participants, 200 mothers whose teenaged children were not vaccinated against HPV...
December 22, 2016: Japan Journal of Nursing Science: JJNS
https://www.readbyqxmd.com/read/28000650/systematic-review-and-meta-analysis-of-single-incision-versus-conventional-multiport-laparoscopic-splenectomy
#19
REVIEW
Shike Wu, Hao Lai, Jiangyang Zhao, Xin Deng, Jianbao Wei, Jian Liang, Xianwei Mo, Jiansi Chen, Yuan Lin
BACKGROUND: There is no consensus that single-incision laparoscopic surgery splenectomy (SILS-SP) is on a par with conventional multiport laparoscopic surgery splenectomy (CMLS-SP). AIMS: The aim of this systematic review and meta-analysis was to assess feasibility and safety of SILS-SP when compared with CMLS-SP. MATERIALS AND METHODS: Eligible articles were identified by searching several databases including PubMed, EMBASE, CNKI (China) and the Cochrane Library, up until February 2016...
December 21, 2016: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/27998363/non-destructive-micro-chemical-and-micro-luminescence-characterization-of-jadeite
#20
Alejandro Mitrani Viggiano, José Luis Ruvalcaba Sil, Mayra D Manrique Ortega, Victoria Corregidor Berdasco
Jadeite was greatly appreciated by pre-Hispanic cultures in Mesoamerica. Despite its importance, knowledge of its mining sources was lost after the Spanish conquest. In the 1950s the only confirmed jadeite deposits in Mesoamerica were found in the Motagua River Fault (MRF), Guatemala. The aim of this study is to present a methodology that is appropriate for the study of archeological jadeite objects using non-destructive spectroscopic and micro-ion beam analysis techniques. This methodology has been applied to perform mineral, elemental, and luminescence characterization of five jadeite samples from the MRF, with white, lilac, and green colors...
December 2016: Microscopy and Microanalysis
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