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https://www.readbyqxmd.com/read/28644262/host-related-risk-factors-for-adherent-perinephric-fat-in-healthy-individuals-undergoing-laparoscopic-living-donor-nephrectomy
#1
Shintaro Narita, Teruaki Kumazawa, Norihiko Tsuchiya, Huang Mingguo, Mitsuru Saito, Takamitsu Inoue, Hiroshi Tsuruta, Kazuyuki Numakura, Atsushi Maeno, Hiroshi Nanjo, Shigeru Satoh, Tomonori Habuchi
PURPOSE: The purpose of this study is to assess the risk factors and characteristics of adherent perinephric fat (APF) in healthy individuals. PATIENTS AND METHODS: Men who underwent laparoscopic donor nephrectomy were included. Video review was used to divide patients on the basis of APF severity. Relationship between APF scores and clinical and radiographic features was evaluated. RESULTS: Of the 92 patients, 43 (46.7%) and 8 (8.7%) were categorized as APF and severe APF, respectively...
June 21, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28642703/different-regulation-of-interleukin-1-production-and-activity-in-monocytes-and-macrophages-innate-memory-as-an-endogenous-mechanism-of-il-1-inhibition
#2
Mariusz P Madej, Elfi Töpfer, Diana Boraschi, Paola Italiani
Production and activity of interleukin (IL)-1β are kept under strict control in our body, because of its powerful inflammation-promoting capacity. Control of IL-1β production and activity allows IL-1 to exert its defensive activities without causing extensive tissue damage. Monocytes are the major producers of IL-1β during inflammation, but they are also able to produce significant amounts of IL-1 inhibitors such as IL-1Ra and the soluble form of the decoy receptor IL-1R2, in an auto-regulatory feedback loop...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28642555/chlorhexidine-mouthwash-plaque-levels-and-gingival-health
#3
Derek Richards
Data sourcesCochrane Oral Health's Trials Register; Cochrane Central Register of Controlled Trials (CENTRAL) Medline; clinicaltrials.gov and the World Health Organization International Clinical Trials Registry Platform. There were no language or date restrictions on searches.Study selectionRandomised controlled trials (RCTs) assessing the effects of chlorhexidine mouthrinse used as an adjunct to mechanical oral hygiene procedures for at least four weeks on gingivitis in children and adults.Data extraction and synthesisTwo reviewers independently abstracted data and assessed risk of bias...
June 23, 2017: Evidence-based Dentistry
https://www.readbyqxmd.com/read/28642553/effect-of-essential-oil-mouthwashes-on-plaque-and-gingivitis
#4
Derek Richards
Data sourcesMedline, Embase, LILACS and Scopus database.Study selectionStudies were screened independently by three reviewers. Randomised controlled trials with a minimum of six months follow-up of daily use of essential oils-containing (EO) mouthwashes compared with placebo, flossing or cetylpyridinium chloride (CPC) as adjuncts to mechanical plaque control were considered.Data extraction and synthesisData were abstracted by two reviewers and study quality assessed using the Cochrane risk of bias tool. Dental plaque was summarised using the Turesky modification of the Quigley-Hein Index (QHI), gingivitis using three indices; the Gingival Index (GI) by Loe and Silness, the Modified Gingival Index (MGI) and bleeding upon probing...
June 23, 2017: Evidence-based Dentistry
https://www.readbyqxmd.com/read/28638551/effectiveness-of-flossing-loops-in-the-control-of-the-gingival-health
#5
Francisco Azcarate-Velázquez, Roberto Garrido-Serrano, Gabriel Castillo-Dalí, María-Angeles Serrera-Figallo, Alfonso Gañán-Calvo, Daniel Torres-Lagares
BACKGROUND: One of the key factor in the good condition of periodontal tissues is their daily hygiene. Oral hygiene techniques such brushing and a good interdental hygiene by correct flossing are very important. The aim of this study is to compare the use of dental floss in a loop vs traditional floss in the control of Loe-Silness Gingival Index (IG), Turesky´s Plaque Index (IPT), Gingival Bleeding Index (IS) and the values of interleukin 6 (IL-6) and interleukin 8 (IL-8). MATERIAL AND METHODS: A comparative study of 40 patients in which each patient was his own control, using during 45 days each one of the devices (new loop floss and conventional floss) of interdental hygiene analysed...
June 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28636739/a-comparison-of-tonsillar-surface-swabbing-fine-needle-aspiration-core-sampling-and-dissected-tonsillar-core-biopsy-culture-in-children-with-recurrent-tonsillitis
#6
Saurav Sarkar, Abheek Sil, Soma Sarkar, Biswajit Sikder
In recurrent tonsillitis, the pathogenic bacteria are harbored in the tonsil core, and therefore cultures of superficial swab samples are not particularly accurate in identifying specific types of core bacteria. On the other hand, the results of fine-needle aspiration (FNA) cultures of core samples have been closely correlated with the findings of core cultures in excised tonsils, and both methods are far superior to surface swabbing. We conducted a prospective study to compare the accuracy of culture findings from tonsillar tissue obtained by surface swabbing, FNA sampling of the tonsil core in situ, and core sampling of the excised tonsil in children with recurrent tonsillitis...
June 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28634419/elevated-plasma-levels-of-sil-2r-in-complex-regional-pain-syndrome-a-pathogenic-role-for-t-lymphocytes
#7
Krishna D Bharwani, Maaike Dirckx, Dirk L Stronks, Willem A Dik, Marco W J Schreurs, Frank J P M Huygen
The immune system has long been thought to be involved in the pathophysiology of complex regional pain syndrome (CRPS). However, not much is known about the role of the immune system and specifically T-cells in the onset and maintenance of this disease. In this study, we aimed to evaluate T-cell activity in CRPS by comparing blood soluble interleukin-2 receptor (sIL-2R) levels between CRPS patients and healthy controls. CRPS patients had statistically significant elevated levels of sIL-2R as compared to healthy controls (median sIL-2R levels: 4151 pg/ml (Q3 - Q1 = 5731 pg/ml - 3546 pg/ml) versus 1907 pg/ml (Q3 - Q1: 2206 pg/ml - 1374 pg/ml), p < 0...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28630024/proteolytic-control-of-interleukin-11-and-interleukin-6-biology
#8
REVIEW
Juliane Lokau, Maria Agthe, Charlotte M Flynn, Christoph Garbers
Interleukin-11 (IL-11) and IL-6 are secreted glycoproteins which fulfill important homeostatic functions. Activation of target cells occurs via membrane-bound IL-11 and IL-6 receptors (IL-11R and IL-6R, respectively). Formation of IL-11/IL-11R and IL-6/IL-6R complexes triggers the recruitment of a homodimer of the ubiquitously expressed signal-transducing β-receptor gp130 (classic signaling). IL-11R and IL-6R can be shed by several proteases, albeit with different preferences and specificities, and these soluble receptors (sIL-11R and sIL-6R) act as agonists and can activate in principle all cells via gp130...
June 16, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28629412/cross-cultural-validation-of-health-literacy-measurement-tools-in-italian-oncology-patients
#9
Paola Zotti, Simone Cocchi, Jerry Polesel, Chiara Cipolat Mis, Donato Bragatto, Silvio Cavuto, Alice Conficconi, Carla Costanzo, Melissa De Giorgi, Christina A Drace, Federica Fiorini, Laura Gangeri, Andrea Lisi, Rosalba Martino, Paola Mosconi, Angelo Paradiso, Valentina Ravaioli, Ivana Truccolo, Paolo De Paoli
BACKGROUND: The aim of this study was to assess the psychometric characteristics of four Health Literacy (HL) measurement tools, viz. Newest Vital Sign (NVS), Short Test of Functional Health Literacy in Adults (STOFHLA), Single Item Literacy Screener (SILS) and Single question on Self-rated Reading Ability (SrRA) among Italian oncology patients. METHODS: The original version of the tools were translated from the English language into Italian using a standard forward-backward procedure and according to internationally recognized good practices...
June 19, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28627606/effects-of-ischemic-preconditioning-on-pdgf-bb-expression-in-the-gerbil-hippocampal-ca1-region-following-transient-cerebral-ischemia
#10
Jae-Chul Lee, Yang Hee Kim, Tae-Kyeong Lee, In Hye Kim, Jeong Hwi Cho, Geum-Sil Cho, Bich-Na Shin, Joon Ha Park, Ji Hyeon Ahn, Myoung Cheol Shin, Jun Hwi Cho, Il Jun Kang, Moo-Ho Won, Jeong Yeol Seo
Ischemic preconditioning (IPC) is induced by exposure to brief durations of transient ischemia, which results in ischemic tolerance to a subsequent longer or lethal period of ischemia. In the present study, the effects of IPC (2 min of transient cerebral ischemia) were examined on immunoreactivity of platelet‑derived growth factor (PDGF)‑BB and on neuroprotection in the gerbil hippocampal CA1 region following lethal transient cerebral ischemia (LTCI; 5 min of transient cerebral ischemia). IPC was subjected to a 2‑min sublethal ischemia and a LTCI was given 5‑min transient ischemia...
June 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28623455/-single-incision-laparoscopy-current-status
#11
REVIEW
H Weiss, C Mittermair, M Weiss
BACKGROUND: Since the introduction of single incision laparoscopy (SIL), there has been disagreement among professional societies regarding a general recommendation for the use of this minimally invasive method. OBJECTIVES: Determination of evidence-based advantages of SIL compared to multiport laparoscopy (MPL). MATERIALS AND METHODS: Description of recent technical developments and evaluation of prospective randomized clinical trials and valid meta-analyses with regard to organ-specific procedures...
June 16, 2017: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/28618867/human-articular-chondrocytes-induce-interleukin-2-nonresponsiveness-to-allogeneic-lymphocytes
#12
Satomi Abe, Hitoshi Nochi, Hiroshi Ito
Introduction We previously showed that articular chondrocytes (ACs) have immune privilege and immunomodulatory functions like those of mesenchymal stem cells. To elucidate these mechanisms, we focused on interleukin-2 (IL-2), which plays critical roles in lymphocyte mitogenic activity. The purpose of this study was to explore whether ACs affect the role of IL-2 underlying immunomodulatory functions. Material and Methods Irradiated human ACs from osteoarthritis donors were used. Third-party ACs were added to the mixed lymphocyte reaction (MLR) with or without recombinant human IL-2 (rhIL-2), and the levels of IL-2 and the soluble form of the IL-2 receptor α (sIL-2Rα) protein in supernatant were measured by enzyme-linked immunosorbent assay...
July 2017: Cartilage
https://www.readbyqxmd.com/read/28618339/hplc-ms-ms-method-for-troventol-determination-in-human-plasma-and-its-application-to-biological-samples
#13
Aleksandra Nikitina, Alexander Grigoriev, Alla Sidorova
For the first time, an HPLC-MS/MS method for the determination pmol/l levels of troventol (TRV) and clenbuterol as an internal standard (IS) in human plasma was developed, validated and tested on biological samples. The method included solid phase extraction by Waters Oasis WCX cartridges and chromatographic separation on a YMC-Pack SIL (100mm×2.1mm, 5μm, 12nm) analytical column with acetonitrile-water-formic acid (50:50:0.1, v/v/v) as the mobile phase; the selected ion transitions were m/z 332.2→138.2 and m/z 277...
April 29, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28606542/hydroxyapatite-crystallization-in-shrimp-cephalothorax-wastes-during-subcritical-water-treatment-for-chitin-extraction
#14
Angélica Espíndola-Cortés, Rosario Moreno-Tovar, Lauro Bucio, Miquel Gimeno, José Luis Ruvalcaba-Sil, Keiko Shirai
The extraction of calcareous chitin from shrimp cephalothorax was successfully achieved using a subcritical water treatment to attain a deproteinization up to 96%. The treatments also increased the crystalline domain size in the α-chitin fibers. An experimental design of Taguchi allowed the optimization of experiments. The macroelements identified in all samples were Ca, P, S, K, Cl and Al, whereas Cr, Mn, Fe, Ni, Cu, Zn, Br and Sr were also detected as microelements. The assigned crystalline phases by XRD were α-chitin, calcite, HAP and traces of quartz...
September 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28606225/-clinical-characteristics-and-prognostic-analysis-of-children-and-adolescents-over-10-years-of-age-with-acute-lymphoblastic-leukemia
#15
Jun Wu, Ai-Dong Lu, Le-Ping Zhang
OBJECTIVE: To explore the clinical characteristics and prognosis of children and adolescents over 10 years of age with acute lymphoblastic leukemia (ALL). METHODS: A total of 86 newly diagnosed ALL children and adolescents over 10 years of age (62 cases of B-ALL and 24 cases of T-ALL) were enrolled. Clinical characteristics, therapeutic effect and prognostic factors were retrospectively analyzed. Event-free survival (EFS) and overall survival (OS) rates were estimated by the Kaplan-Meier method...
June 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28606156/expression-of-mrna-il-17f-and-sil-17f-in-atopic-asthma-patients
#16
Mochammad Hatta, Eko E Surachmanto, Andi Asadul Islam, Syarifuddin Wahid
BACKGROUND: Asthma is a chronic inflammatory disorder of airway that involves many cells and elements. Chronic inflammation caused by increase Airway hyperresponsiveness that cause recurrent episodic symptoms of breathlessness, wheezing, chest tightness and coughing, especially at night or early morning. Interleukin 17F is a cytokine that plays an important role in the pathophysiology of asthma attacks. Some studies show a variety of IL-17F roles in the pathogenesis of airway inflammation due to an allergic reaction...
June 12, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28605192/absolute-protein-quantification-by-mass-spectrometry-not-as-simple-as-advertised
#17
Christopher M Shuford, James J Walters, Patricia M Holland, Uma Sreenivasan, Nadav Askari, Kevin B Ray, Russell P Grant
Stable-isotope labeled (SIL) tryptic peptides, cleavable SIL peptides, and a full-length SIL protein were compared for internal calibration (i.e., as internal calibrators) and external calibration (i.e., as internal standards) when quantifying three forms of unlabeled, human thyroglobulin (Tg) by bottom-up protein analysis. All SIL materials and human proteins were standardized by amino acid analysis to ensure traceability of measurements and allow confident assignment of accuracy. The three forms of human Tg quantified were 1) the primary reference material BCR®457 - a native protein purified from human thyroids - 2) a commercially available form also purified from human thyroids, and 3) a full-length recombinant form expressed and purified from a human embryonic kidney 293 cell-line...
June 12, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28604377/minimally-invasive-distal-pancreatectomy-a-retrospective-review-of-30-cases
#18
Aziz Su Mer, Umut Barbaros, Salvador Morales Conde, Sebahattin Celik, Nihat Aksakal, Jose Maria Alamo, Isaias Alarcon, Nazim Gu Res, Hamit Karayagiz, Ahmet Dinccag, Ridvan Seven, Selcuk Mercan, Demir Budak
OBJECTIVES: Pancreatic surgery has been greatly influenced by the advent of laparoscopic surgery and increasing experience in its performance and by advances in techniques and surgical devices. This study aimed to represent two centers' initial experiences in laparoscopic distal pancreatic surgery. METHODS: This study was a bi-centric study including 30 patients undergoing distal pancreatectomy for pancreatic disorders. All the patients were operated on from November 2006 to November 2013 in Turkey and Spain...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28603542/-low-grade-squamous-intraepithelial-lesion-cannot-exclude-high-grade-tbs-says-don-t-use-it-should-i-really-stop-it
#19
Jeanine M Chiaffarano, Melissa Alexander, Robert Rogers, Fang Zhou, Joan Cangiarella, Melissa Yee-Chang, Paul Elgert, Aylin Simsir
BACKGROUND: The Bethesda System uses a two-tiered approach in the diagnosis of cervical squamous intraepithelial lesions (SILs). Occasionally, Papanicolaou (Pap) tests with evident low-grade SIL (LSIL) also have some features suggestive but not diagnostic of high-grade SIL (HSIL). This study reviews our experience with "Low-grade Squamous Intraepithelial Lesion, Cannot Exclude High-grade" (LSIL-H) and discusses the best approach to report such Paps if the LSIL-H interpretation is abandoned...
2017: CytoJournal
https://www.readbyqxmd.com/read/28603026/widespread-reduction-of-dopamine-cell-bodies-and-terminals-in-adult-rats-exposed-to-a-low-dose-regimen-of-mdma-during-adolescence
#20
Cristina Cadoni, Augusta Pisanu, Nicola Simola, Lucia Frau, Pier Francesca Porceddu, Silvia Corongiu, Christian Dessì, Annesha Sil, Antonio Plumitallo, Jadwiga Wardas, Gaetano Di Chiara
Although MDMA (3,4-methylendioxymethamphetamine, ecstasy) neurotoxicity in serotonin neurons is largely recognized in a wide variety of species including man, neurotoxicity in dopamine (DA) neurons is thought to be species-specific. MDMA is mainly consumed by adolescents, often in conjunction with caffeine (Energy Drinks) and this association has been reported to exacerbate MDMA toxic effects. In order to model these aspects of MDMA use, vis-à-vis their impact on DA neurons, we investigated the effects of adolescent exposure to low doses of MDMA (5 mg/kg for 10 days), alone or in combination with caffeine (10 mg/kg) on neuronal and functional DA indices and on recognition memory in adult rats...
June 8, 2017: Neuropharmacology
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