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https://www.readbyqxmd.com/read/29792168/trends-in-the-incidence-and-associated-factors-of-late-onset-sepsis-associated-with-improved-survival-in-extremely-preterm-infants-born-at-23-26-weeks-gestation-a-retrospective-study
#1
Jin Kyu Kim, Yun Sil Chang, Sein Sung, So Yoon Ahn, Won Soon Park
BACKGROUND: To investigate the trends in the incidence and associated factors of late-onset sepsis (LOS) associated with improved survival in extremely preterm infants. METHODS: Medical records of 364 infants who were born at 23-26 weeks' gestation from 2000 to 2005 (period I, n = 124) and from 2006 to 2011 (period II, n = 240) were retrospectively reviewed. The infants were stratified into subgroups of 23-24 and 25-26 weeks' gestation within each period, and survival, LOS rate, and clinical characteristics were analyzed...
May 23, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29789162/fatigue-failure-load-of-an-adhesively-cemented-lithium-disilicate-glass-ceramic-conventional-ceramic-etching-vs-etch-prime-one-step-primer
#2
Maitê Munhoz Scherer, Catina Prochnow, Andressa Borin Venturini, Gabriel Kalil Rocha Pereira, Thiago Augusto de Lima Burgo, Marília Pivetta Rippe, Luiz Felipe Valandro
OBJECTIVES: To evaluate the effect of different glass-ceramic surface treatments and aging on the fatigue failure load of a lithium disilicate glass-ceramic adhesively cemented to a dentin analogue material. METHODS: One hundred and twenty (120) disc-shaped lithium disilicate specimens (Ø=10mm, thickness=1.5mm) were produced and randomly allocated (n=20) into 6 groups, considering 2 study factors: "surface treatment" in 3 levels (SIL-silane application only; HF5+SIL-5% hydrofluoric acid etching and silane application; ME&P-etching with an one-step ceramic primer), and "storage" in 2 levels (baseline-storage for 7 days; aging-storage for 90 days+12,000 thermal cycles)...
May 19, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29788762/distinct-patterns-of-internet-and-smartphone-related-problems-among-adolescents-by-gender-latent-class-analysis
#3
Seung-Yup Lee, Donghwan Lee, Cho Rong Nam, Da Yea Kim, Sera Park, Jun-Gun Kwon, Yong-Sil Kweon, Youngjo Lee, Dai Jin Kim, Jung-Seok Choi
Background and objectives The ubiquitous Internet connections by smartphones weakened the traditional boundaries between computers and mobile phones. We sought to explore whether smartphone-related problems differ from those of computer use according to gender using latent class analysis (LCA). Methods After informed consents, 555 Korean middle-school students completed surveys on gaming, Internet use, and smartphone usage patterns. They also completed various psychosocial instruments. LCA was performed for the whole group and by gender...
May 23, 2018: Journal of Behavioral Addictions
https://www.readbyqxmd.com/read/29788707/comparison-of-fatigue-severity-and-quality-of-life-between-unexplained-fatigue-patients-and-explained-fatigue-patients
#4
Eun Hae Yoo, Eun Sil Choi, Soo Hyun Cho, Jae Hyuk Do, Suk Jeong Lee, Jung-Ha Kim
BACKGROUND: Recently, despite the high prevalence of fatigue in patients, there is a lack of research on the quality of life (QoL) in unexplained fatigue patients, indicating that they are not properly diagnosed and treated. The aim of this study was to compare fatigue severity and QoL between patients with explained and unexplained fatigue. METHODS: The study consisted of 200 Korean adults who complained of fatigue without underlying disease. Fatigue Severity Scale, Short Form Health Survey-36 version 2 (SF-36v2), and Beck Depression Inventory-II (BDI-II) self-questionnaires were administered...
May 2018: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/29784793/camp-inducible-coactivator-crtc3-attenuates-brown-adipose-tissue-thermogenesis
#5
Young-Sil Yoon, Wen-Wei Tsai, Sam Van de Velde, Zhijiang Chen, Kuo-Fen Lee, Donald A Morgan, Kamal Rahmouni, Shigenobu Matsumura, Ezra Wiater, Youngsup Song, Marc Montminy
In response to cold exposure, placental mammals maintain body temperature by increasing sympathetic nerve activity in brown adipose tissue (BAT). Triggering of β-adrenergic receptors on brown adipocytes stimulates thermogenesis via induction of the cAMP/PKA pathway. Although cAMP response element-binding protein (CREB) and its coactivators-the cAMP-regulated transcriptional coactivators (CRTCs)-mediate transcriptional effects of cAMP in most tissues, other transcription factors such as ATF2 appear critical for induction of thermogenic genes by cAMP in BAT...
May 21, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29779389/-prevalence-and-severity-of-chronic-parodontitis-and-oral-mucosal-lesions-in-chronic-obstructive-lung-disease
#6
Ágnes Bán, Zsolt Ferenc Németh, Adrienn Szauter, Szilvia Soós, Márta Balaskó
INTRODUCTION: Chronic parodontitis is a prevalent oral disease that may lead to the loss of teeth independently of caries. Some systemic diseases (e.g., diabetes mellitus, chronic renal failure) may aggravate chronic parodontitis. On the other hand, this oral disease may aggravate other systemic diseases. Earlier studies suggested a correlation between chronic parodontitis and very severe chronic obstructive pulmonary disease (COPD). AIM: The aim of our study was the investigation of the correlation between chronic parodontitis and chronic obstructive pulmonary disease...
May 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29779062/synthesis-and-characterization-of-silibinin-phenanthroline-neocuproine-copper-ii-complexes-for-augmenting-bone-tissue-regeneration-an-in-vitro-analysis
#7
Subramaniyam Rajalakshmi, Selvaraj Vimalraj, Sekaran Saravanan, Desingh Raj Preeth, Manickaraj Shairam, Dhanasekaran Anuradha
In the recent decades, flavonoid metal complexes have been widely investigated for their multifaceted role in enabling osteoblast differentiation and bone formation. Silibinin complexed with copper(II) ion has been synthesized along with two mixed ligand complexes, namely copper(II) silibinin-phenanthroline and neocuproine as co-ligands, and their positive role in promoting neovacularization and osteoblast differentiation was investigated. Silibinin mono complex [Cu(sil)(H2 O)2 ] and [Cu(sil)(phen)] showed similar UV-visible absorption in the region of 315 and 222 nm, whereas Cu(silibinin)(neocuproine) [Cu(sil)(neo)] showed a blueshift in the 320 nm transition...
May 19, 2018: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29777860/cross-cultural-adaptation-and-validation-of-the-functional-assessment-of-chronic-illness-therapy-cervical-dysplasia-facit-cd-questionnaire-for-serbian-women
#8
Vesna Kesić, Radmila Sparić, Rafal Watrowski, Jelena Dotlić, Radomir Stefanović, Gorica Marić, Tatjana Pekmezović
OBJECTIVES: The FACIT-CD (Functional Assessment of Chronic Illness Therapy - Cervical Dysplasia) questionnaire is a disease-specific instrument for assessing the health-related quality of life (HRQoL) in women with cervical dysplasia. Our aim was to perform a cross-cultural adaptation and psychometric evaluation of the FACIT-CD scale in Serbian women with cervical squamous intraepithelial lesions (SIL). STUDY DESIGN: Our study included women of reproductive age diagnosed with SIL in a single university-affiliated hospital...
May 16, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29775678/synaptic-transmission-and-excitability-during-hypoxia-with-inflammation-and-reoxygenation-in-hippocampal-ca1-neurons
#9
Yoon-Sil Yang, Sook Jin Son, Joon Ho Choi, Jong-Cheol Rah
Although a number of experimental and clinical studies have shown that hypoxia typically accompanies acute inflammatory responses, the combinatorial effect of the two insults on basic neural function has not been thoroughly investigated. Previous studies have predominantly suggested that hypoxia reduces network activity; however, several studies suggest the opposite effect. Of note, inflammation is known to increase neural activity. In the current study, we examined the effects of limited oxygen in combination with an inflammatory stimulus, as well as the effects of reoxygenation, on synaptic transmission and excitability...
May 15, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29769612/hypothermia-broadens-the-therapeutic-time-window-of-mesenchymal-stem-cell-transplantation-for-severe-neonatal-hypoxic-ischemic-encephalopathy
#10
So Yoon Ahn, Yun Sil Chang, Dong Kyung Sung, Se In Sung, Won Soon Park
Recently, we have demonstrated that concurrent hypothermia and mesenchymal stem cells (MSCs) transplantation synergistically improved severe neonatal hypoxic ischemic encephalopathy (HIE). The current study was designed to determine whether hypothermia could extend the therapeutic time window of MSC transplantation for severe neonatal HIE. To induce HIE, newborn rat pups were exposed to 8% oxygen for 2 h following unilateral carotid artery ligation on postnatal day (P) 7. After approving severe HIE involving >50% of the ipsilateral hemisphere volume, hypothermia (32 °C) for 2 days was started...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29766651/adhesive-silane-application-effects-on-bond-strength-durability-to-a-lithium-disilicate-ceramic
#11
Jose C Romanini-Junior, Rose Y Kumagai, Luiz F Ortega, Jose A Rodrigues, Alessandra Cassoni, Ronaldo Hirata, Andre F Reis
OBJECTIVE: To test the effects of different adhesive protocols and silane application on the adhesive durability to a Lithium Disilicate reinforced glass ceramic. METHODS: Forty disks of 13 mm diameter (E.max Press) were used. After etching with 9.5% HF for 20 seconds, disks were randomly assigned into 4 groups according to the adhesive/silane protocol: silane application only (SIL); silane application followed by adhesive (SILXP-XP Bond); silane-containing adhesive (SBU-ScotchBond Universal); silane application followed by silane-containing adhesive (SILSBU)...
May 15, 2018: Journal of Esthetic and Restorative Dentistry
https://www.readbyqxmd.com/read/29765769/synthesis-and-crystallographic-characterization-of-2-2-bis-%C3%AE-5-penta-methyl-cyclo-penta-dien-yl-3-4-bis-tri-methyl-sil-yl-2-zircona-furan-5-one-%C3%AE%C2%BA-o-5-triisobutyl-aluminium
#12
Vladimir V Burlakov, Vyacheslav S Bogdanov, Perdita Arndt, Anke Spannenberg, Uwe Rosenthal, Torsten Beweries, Vladimir B Shur
The crystal structure of the title zwitterionic zirconocene complex containing a furan-one unit, [AlZr(C10 H15 )2 (C4 H9 )3 (C9 H18 O2 Si2 )], is reported. On reacting a zircona-furan-one with two equivalents of HAl( i -Bu)2 , disproportionation of the Lewis acid results in the formation of a triiso-butyl-aluminium fragment, Al( i -Bu)3 , which coordinates to the exocyclic carbonyl O atom of the zircona-furan-one ring. Single-crystal X-ray diffraction reveals that the zircona-furan-one ring remains intact with coordination of the aluminium to the exocyclic O atom...
April 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29765762/tris-2-2-6-6-tetra-methyl-8-tri-methyl-sil-yl-benzo-1-2-d-4-5-d-bis-1-3-di-thiol-4-yl-methanol-diethyl-ether-monosolvate
#13
Nico Fleck, Gregor Schnakenburg, Alexander C Filippou, Olav Schiemann
The title compound, a tri-aryl-methanol, C46 H64 OS12 Si3 1 , was synthesized via li-thia-tion of tris-2,2,6,6-tetra-methyl-benzo[1,2- d ;4,5- d ']bis-[1,3]di-thiol-4-yl-methanol, 2 , and electrophilic quenching with tri-methyl-silyl chloride. The current crystal structure reveals information about the reactivity of this compound and compares well with the structure reported for the unsubstituted parent compound 2 [Driesschaert et al. (2012 ▸). Eur. J. Org. Chem. 33 , 6517-6525]. The title compound 1 forms mol-ecular propellers and crystallizes in P [Formula: see text], featuring an unusually long Si-Car bond of 1...
April 1, 2018: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/29763682/melatonin-attenuates-arsenic-induced-nephropathy-via-the-regulation-of-oxidative-stress-and-inflammatory-signaling-cascades-in-mice
#14
Sayanta Dutta, Sukanya Saha, Sushweta Mahalanobish, Pritam Sadhukhan, Parames C Sil
Arsenic is a potent inducer of several acute and chronic nephrotoxic disorders. It promotes deleterious phenomenon like oxidative stress, inflammation, cell death and altered glucose uptake leading to distorted kidney homeostasis that end up in chronic kidney disease. This study investigated the possible protective role of melatonin; a natural antioxidant produced by the pineal gland, against arsenic induced nephrotoxicity. Melatonin successfully ameliorated arsenic induced renal toxicity both in in vitro and in vivo models...
May 12, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29759036/the-association-between-occupational-lead-exposure-and-serum-levels-of-selected-soluble-receptors
#15
Anna Machoń-Grecka, Michał Dobrakowski, Aleksandra Kasperczyk, Ewa Birkner, Ilona Korzonek-Szlacheta, Sławomir Kasperczyk
The present study was designed to evaluate soluble receptors as potential targets for lead (Pb). Analyses included the serum levels of soluble Vascular Endothelial Growth Factor Receptors 2 (sVEGFR-2), soluble Epidermal Growth Factor Receptor (sEGFR), soluble Human Epidermal Growth Factor 2 (sHER-2/neu), and soluble Interleukin 6 Receptors (sIL-6R) in the groups of chronically and subchronically occupationally exposed workers. The first group consisted of 56 male workers chronically exposed to Pb. The second group (control) comprised 24 male administrative workers...
January 1, 2018: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/29758315/ameliorative-role-of-ferulic-acid-against-diabetes-associated-oxidative-stress-induced-spleen-damage
#16
Sumit Ghosh, Sayantani Chowdhury, Poulami Sarkar, Parames C Sil
Spleen, a secondary lymphoid organ, is the site of initiation of most of the immune responses. The present study is centered on the ameliorative role of ferulic acid against diabetic complications in the spleen of male wistar rats. Induction of diabetes by STZ (at a dose of 50 mg kg-1 body wt, i.p.) reduced the spleen size, plasma insulin level, enhanced the blood glucose level and disrupted the intracellular antioxidant machineries along with the depletion of splenic white pulp. Induction of oxidative stress mediated inflammation and apoptosis (upregulation in the levels of inflammatory cytokines, translocation of NF ĸB in the nucleus, alteration in Bax/Bcl-2 ratio, release of cytochrome c from mitochondria, activation of caspase-9 and 3, PARP cleavage and DNA fragmentation) were evidenced from immunoblot analyses, DNA fragmentation and TUNEL assay...
May 11, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29755564/a-new-taraxastane-triterpene-from-euphorbia-denticulata-with-cytotoxic-activity-against-prostate-cancer-cells
#17
Sara Shamsabadipour, Seyed Mohammad Zarei, Mustafa Ghanadian, Seyed Abdulmajid Ayatollahi, Mohammad Reza Rahimnejad, Hojjatollah Saeedi, Mahmoud Aghaei
In this research, aerial parts of Euphorbia denticulata Lam were collected from Sanandaj city in Kurdistan province at the West of Iran. It was extracted by maceration using acetone as solvent. The isolation of compounds were carried out with repeated column chromatography using silica gel and normal preparative HPLC using YMC-Pack-Sil column and hexane: ethyl acetate as mobile phase. The structures of isolated compounds were elucidated by extensive 1 and 2D-NMR as well as HRESI-MS spectra and the cytotoxicity was done against DU-145 human prostate cancer cell line using standard MTT assay...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29752775/microrna-92a-promotes-tumor-growth-and-suppresses-immune-function-through-activation-of-mapk-erk-signaling-pathway-by-inhibiting-pten-in-mice-bearing-u14-cervical-cancer
#18
Zeng-Hui Li, Lei Li, Lin-Ping Kang, Yan Wang
Cervical cancer is known as the possible outcome of genital infection, while the molecular mechanisms of initiation, development, and metastasis of cervical cancer have not yet been fully elucidated. Our study aims to investigate the effects of microRNA-92a (miR-92a) on tumor growth and immune function by targeting PTEN via the MAPK/ERK signaling pathway in tumor-bearing mice. C57BL/6 female mice were used for tumor-bearing mouse models and their tumor and adjacent normal tissues were collected, and normal cervical tissues were obtained from normal mice...
May 11, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29752408/interleukin-6-mediated-trans-signaling-inhibits-transforming-growth-factor-%C3%AE-signaling-in-trabecular-meshwork-cells
#19
Miyuki Inoue-Mochita, Toshihiro Inoue, Sachi Kojima, Akiko Futakuchi, Tomokazu Fujimoto, Saori Sato-Ohira, Utako Tsutsumi, Hidenobu Tanihara
Glaucoma is one of the major causes of blindness, and TGF-β2 has been found to be elevated in the aqueous humor of eyes with primary open-angle glaucoma (POAG). TGF-β2 in aqueous humor causes the glaucoma-related fibrosis of human trabecular meshwork (HTM), suggesting an important role of TGF-β in POAG pathogenesis. Here, we sought to elucidate the effects of IL-6 trans-signaling on TGF-β signaling in HTM cells. Using a multiplex immunoassay, POAG patients decreased IL-6 levels and increased soluble IL-6 receptor (sIL-6R) levels compared with the controls...
May 11, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29749103/a-robotic-suture-passing-device-for-possible-use-in-sils-and-notes
#20
Muhammad Umar Farooq, Woo Young Kim, Seong Young Ko
BACKGROUND: Natural orifice transluminal endoscopic (NOTES) and single incisional laparoscopic surgeries (SILS) have been gaining importance over the last two decades. Due to improper instrumentation, small workspace and the imperceptibility of body structures, suturing and knot-tying are difficult to perform in both. METHODS: An intracorporeal suture-passing device with two manipulator arms is proposed that automatically passes the suture around ducts of up to 7 mm diameter, without additional manipulation of any other surgical instrument, and it can be deployed through a trocar of 3 mm inner diameter...
May 11, 2018: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
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