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https://www.readbyqxmd.com/read/28742355/tfsi-and-tdi-anions-probes-for-solvate-ionic-liquid-and-disproportionation-based-lithium-battery-electrolytes
#1
Piotr Jankowski, Maciej Dranka, Wladyslaw Grzegorz Wieczorek, Patrik Johansson
Highly concentrated electrolytes based on Li-salts and chelating solvents, such as glymes, are promising as electrolytes for lithium batteries. This is due to their unique properties, such as higher electrochemical stabilities, compliance with high voltage electrodes, low volatility and flammability, and inertness towards aluminium current collector corrosion. The nature of these properties originates from the molecular level structure created in either solvate ionic liquids (SILs) or the less common ionic aggregates by disproportionation reactions...
July 25, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28740350/cryptogenic-multifocal-ulcerous-stenosing-enteritis-radiologic-features-and-clinical-behavior
#2
Jiyoung Hwang, Jin Sil Kim, Ah Young Kim, Joon Seok Lim, Se Hyung Kim, Min Ju Kim, Mi Sung Kim, Kyoung Doo Song, Ji Young Woo
AIM: To investigate the characteristic radiologic findings of cryptogenic multifocal ulcerous stenosing enteritis (CMUSE) which can be differentiated from other similar bowel disease and to assess their clinical behavior. METHODS: Twenty pathologically and clinically confirmed CMUSE patients (males:females = 8:12; mean age: 40.4 years) between March 2002 and August 2015 from seven academic centers in South Korea were retrospectively reviewed. We evaluated small bowel series (SBS; n = 25), computed tomography (CT) enterography (n = 21), magnetic resonance (MR) enterography (n = 2), and abdominopelvic CT (n = 18) images, focusing on enteric and perienteric manifestations...
July 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28739265/role-of-adam10-in-intestinal-crypt-homeostasis-and-tumorigenesis
#3
Peter J Dempsey
A disintegrin and metalloproteinases (ADAMs) are a family of multidomain, membrane-anchored proteases that regulate diverse cellular functions, including cell adhesion, migration, proteolysis and other cell signaling events. Catalytically-active ADAMs act as ectodomain sheddases that proteolytically cleave type I and type II transmembrane proteins and some GPI-anchored proteins from the cellular surface. ADAMs can also modulate other cellular signaling events through a process known as regulated intramembrane proteolysis (RIP)...
July 21, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28738387/false-negative-rate-of-papanicolaou-testing-a-national-survey-from-the-thai-society-of-cytology
#4
Supinda Koonmee, Andrey Bychkov, Somruetai Shuangshoti, Kanyaprin Bhummichitra, Wanwisa Himakhun, Anant Karalak, Samreung Rangdaeng
OBJECTIVE: To evaluate the performance of Papanicolaou smear screening in Thailand at the national level, and to propose recommendations for continuing quality control. STUDY DESIGN: This study was conducted by The Thai Society of Cytology and involved 124 laboratories in 76 provinces during 2010-2014. Random sampling suggested recalling of 10% of slides defined as negative at routine screenings (10% random rescreening [R10] model) directly from the reading unit...
July 25, 2017: Acta Cytologica
https://www.readbyqxmd.com/read/28737916/the-conjugated-double-bond-of-coniferyl-aldehyde-is-essential-for-heat-shock-factor-1-mediated-cytotoprotection
#5
Seul-Ki Choi, Gil-Im Mun, Eun Choi, Seo-Young Kim, Youngjoo Kwon, Younghwa Na, Yun-Sil Lee
Coniferyl aldehyde (1) is previously reported as a potent inducer of heat shock factor 1 (HSF1). Here, we further examined the active pharmacophore of 1 for activation of HSF1 using the derivatives coniferyl alcohol (2), 4-hydroxy-3-methoxyphenylpropanal (3), and 4-hydroxy-3-methoxyphenylpropanol (4). Both 1 and 2 resulted in increased survival days after a lethal radiation (IR) dose. The decrease in bone marrow (BM) cellularity and Ki67-positive BM cells by IR was also significantly restored by 1 or 2 in mice...
July 24, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28736882/the-clinical-significance-of-monitoring-the-expression-of-the-sil-tal1-fusion-gene-in-t-cell-acute-lymphoblastic-leukemia-after-allogeneic-hematopoietic-stem-cell-transplantation
#6
X Zhao, Y Hong, Y Qin, Y Xu, Y Chang, Y Wang, X Zhang, L Xu, X Huang
INTRODUCTION: SIL-TAL1 rearrangement is common in T-cell acute lymphoblastic leukemia (T-ALL). However, whether this fusion gene might be used as a reliable marker of minimal residual disease (MRD) following allogeneic stem cell transplantation (allo-HSCT) remains unknown METHODS: The clinical data of consecutive 29 patients with T-ALL who received allo-HSCT were collected. Their MRD were evaluated by SIL-TAL1, Wilms' tumor 1 (WT1) expression, and the leukemia-associated immunophenotype (LAIP) ...
July 24, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28735867/cleavage-of-the-interleukin-11-receptor-induces-processing-of-its-c-terminal-fragments-by-the-gamma-secretase-and-the-proteasome
#7
Juliane Lokau, Charlotte M Flynn, Christoph Garbers
The cytokine Interleukin-11 (IL-11) signals through the membrane-bound IL-11 receptor (IL-11R), which is expressed in a cell-type specific manner. We have recently shown that the metalloprotease ADAM10 can cleave the IL-11R. The liberated soluble IL-11R (sIL-11R) ectodomain can bind its ligand, and the resulting IL-11/sIL-11R complex can activate cells that do not express the IL-11R (trans-signaling). In this study, we show that the remaining C-terminal fragment (CTF1) after ADAM10-mediated cleavage is subsequently cleaved within the membrane by the gamma-secretase complex, and that the resulting shorter CTF2 is further degraded by the proteasome...
July 20, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28733560/mir-122-socs1-jak2-axis-regulates-allergic-inflammation-and-allergic-inflammation-promoted-cellular-interactions
#8
Kyeonga Noh, Misun Kim, Youngmi Kim, Hanearl Kim, Hyuna Kim, Jaehwan Byun, Yeongseo Park, Hansoo Lee, Yun Sil Lee, Jongseon Choe, Young Myeong Kim, Dooil Jeoung
The regulatory role of suppressor of cytokine signaling 1 (SOCS1) in inflammation has been reported. However, its role in allergic inflammation has not been previously reported. SOCS1 mediated in vitro and in vivo allergic inflammation. Histone deacetylase-3 (HDAC3), a mediator of allergic inflammation, interacted with SOCS1, and miR-384 inhibitor, a positive regulator of HDAC3, induced features of allergic inflammation in an SOCS1-dependent manner. miRNA array analysis showed that the expression of miR-122 was decreased by antigen-stimulation...
July 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28728856/achaete-scute-complex-homologue-2-accelerates-the-development-of-sj%C3%A3-gren-s-syndrome-like-disease-in-the-nod-shiltj-mouse
#9
Sung-Min Kim, Jeong-Eun Kwon, Jin-Sil Park, Hyeon-Beom Seo, Kyung-Ah Jung, Young-Mee Moon, Jennifer Lee, Seung-Ki Kwok, Mi-La Cho, Sung-Hwan Park
Achaete-scute complex homologue 2 (Ascl2) has been reported to induce the differentiation and activation of follicular helper T (TFH) cells, which are essential for development of Sjögren's syndrome (SS). This study examined whether Ascl2 plays a role in the development of SS. NOD/ShiLtJ mice were injected with an Ascl2-overexpression vector, and the infiltration of lymphocytes into salivary and lacrimal glands was assessed. The expression of inflammatory cytokines and chemoattractants for T or B cells was measured...
July 17, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28727634/is-single-incision-laparoscopic-cholecystectomy-feasible-for-acute-cholecystitis-a-consecutive-study-of-60-cases
#10
Noriaki Koizumi, Hiroki Kobayashi, Tsuyoshi Takagi, Kanehisa Fukumoto
The feasibility of single-incision laparoscopic cholecystectomy (SIL-C) for patients with acute cholecystitis were evaluated based on the timing of operation after onset of symptoms. Sixty patients with acute cholecystitis who underwent SIL-C were divided into 2 groups according to the timing of operation: group E included 23 patients who underwent SIL-C within 72 hours, and group O included 37 patients who underwent SIL-C later. There were no statistical differences between group E and group O in clinicopathologic characteristics...
July 19, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28726142/single-incision-surgery-trocar-site-hernia-an-updated-systematic-review-meta-analysis-with-trial-sequential-analysis-by-the-minimally-invasive-surgery-synthesis-of-interventions-outcomes-network-mission
#11
Stavros A Antoniou, Josep M García-Alamino, Shahab Hajibandeh, Shahin Hajibandeh, Michael Weitzendorfer, Filip E Muysoms, Frank A Granderath, George E Chalkiadakis, Klaus Emmanuel, George A Antoniou, Meropi Gioumidou, Styliani Iliopoulou-Kosmadaki, Maria Mathioudaki, Kyriakos Souliotis
BACKGROUND: Single-incision laparoscopic surgery (SILS) is a new technique that aims to minimize abdominal wall trauma and improve cosmesis. Concerns have been raised about the risk of trocar-site hernia following SILS. This study aims to assess the risk of trocar-site hernia following SILS compared to conventional laparoscopic surgery, and investigate whether current evidence is conclusive. METHODS: We performed a systematic search of MEDLINE, AMED, CINAHL, CENTRAL, and OpenGrey...
July 19, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28723379/minilaparoendoscopic-single-site-pyeloplasty-the-best-compromise-between-surgeon-s-ergonomy-and-patient-s-cosmesis-ideal-phase-2a
#12
Francesco Greco, Giovannalberto Pini, Stefano Alba, Vincenzo Maria Altieri, Paolo Verze, Vincenzo Mirone
BACKGROUND: Laparoendoscopic single-site (LESS) surgery and minilaparoscopy (ML) represent the evolution of laparoscopy for the treatment of urologic diseases. OBJECTIVE: To describe the technique and report the surgical outcomes of minilaparoendoscopic single-site dismembered pyeloplasty (MILESS-DP), a new technique overcoming the technical limitations of LESS and ML, and equally combining the advantages of both these surgical procedures. DESIGN, SETTING, AND PARTICIPANTS: Twenty consecutive patients underwent MILESS-DP for ureteropelvic junction obstruction...
August 2016: European Urology Focus
https://www.readbyqxmd.com/read/28720443/squamous-intraepithelial-lesions-of-the-anal-squamocolumnar-junction-histopathological-classification-and-hpv-genotyping
#13
Omar Clavero, Jenny McCloskey, Vicente Marco Molina, Beatriz Quirós, Ignacio G Bravo, Silvia de Sanjosé, F Xavier Bosch, Ville N Pimenoff
BACKGROUND: Human papillomavirus (HPV)-related anal cancer lesions are often found adjacent to the squamocolumnar junction (SCJ). We have assessed the histopathology and associated HPV genotypes in anal SCJ lesions in surgically excised anal warts in HIV-negative and -positive patients. METHODS: Histopathology identified 47 squamous intraepithelial lesions (SILs) adjacent to the SCJ amongst a total of 145 cases of clinically diagnosed anal condylomata. The anal SCJ lesions were further analyzed with p16, CK7 and p63 immunohistochemistry and HPV genotyping...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28717087/pulmonary-intravascular-large-b-cell-lymphoma-ivlbcl-disguised-as-an-asthma-exacerbation-in-a-patient-with-asthma
#14
Tomohito Takeshige, Norihiro Harada, Yasuhito Sekimoto, Ryota Kanemaru, Takeo Tsutsumi, Kei Matsuno, Satomi Shiota, Azuchi Masuda, Akihiko Gotoh, Miki Asahina, Toshimasa Uekusa, Kazuhisa Takahashi
A 62-year-old man with asthma presented with a 1-month history of wheezing and exertional dyspnea. Although the wheezing symptoms disappeared after systemic corticosteroid therapy, the exertional dyspnea and hypoxemia did not improve. A diagnosis of intravascular large B-cell lymphoma (IVLBCL) with pulmonary involvement was suspected because of the increased serum lactic dehydrogenase (LDH) and soluble interleukin-2 receptor (sIL-2R) level, increased alveolar-arterial oxygen difference (AaDO2), decreased pulmonary diffusing capacity for carbon monoxide (DLCO) and scintigraphic, computed tomography (CT) and (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET)-CT findings...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28712702/clinical-usefulness-of-f-18-fdg-pet-in-lymphoepithelioma-like-gastric-carcinoma
#15
Soyeon Park, Dakeun Lee, Kee Myung Lee, Sang-Uk Han, Jei Hee Lee, Su Jin Lee, Young-Sil An, Joon-Kee Yoon
PURPOSE: Lymphoepithelioma-like carcinoma (LELC) is a rare type of gastric cancer. We evaluated the clinical usefulness of F-18 FDG positron emission tomography/computed tomography (PET/CT) in LELC of stomach. MATERIALS AND METHODS: A total of 28 patients (mean age=59years) who underwent preoperative F-18 FDG PET/CT were enrolled retrospectively. Nine patients underwent follow-up F-18 FDG PET/CT. Pathologic information was obtained through gastrectomy and the association with Epstein-Barr virus (EBV) was investigated in 26 patients...
June 27, 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28711624/curcumin-attenuates-oxidative-stress-induced-nf%C3%AE%C2%BAb-mediated-inflammation-and-endoplasmic-reticulum-dependent-apoptosis-of-splenocytes-in-diabetes
#16
Kahkashan Rashid, Sayantani Chowdhury, Sumit Ghosh, Parames C Sil
The present study was aimed to determine the curative role of curcumin against diabetes induced oxidative stress and its associated splenic complications. Diabetes was induced in the experimental rats via the intraperitoneal administration of a single dose of STZ (65 mg kg(-1) body weight). Increased blood glucose and intracellular ROS levels along with decreased body weight, the activity of cellular antioxidant enzymes and GSH/GSSG ratio were observed in the diabetic animals. Histological assessment showed white pulp depletion and damaged spleen anatomy in these animals...
July 12, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28710515/quantitative-lc-esi-srm-ms-of-antibody-biopharmaceuticals-use-of-a-homologous-antibody-as-an-internal-standard-and-three-step-method-development
#17
Fumio Osaki, Kenji Tabata, Tomoyuki Oe
Monoclonal antibody-based therapeutic agents (antibody drugs) have attracted considerable attention as a new type of drug. Concomitantly, the use of quantitative approaches for characterizing antibody drugs, such as liquid chromatography (LC)-mass spectrometry (MS), has increased. Generally, selective quantification of antibody drugs is done using unique peptides from variable regions (V H and V L) as surrogate peptides. Further, numerous internal standards (ISs) such as stable isotope-labeled (SIL)-intact proteins and SIL-surrogate peptides are used...
July 14, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28705998/is-normobaric-hypoxia-an-effective-treatment-for-sustaining-previously-acquired-altitude-acclimatization
#18
Beth A Beidleman, Charles S Fulco, Bruce S Cadarette, Allen Cymerman, Mark J Buller, Roy M Salgado, Alexander M Posch, Janet E Staab, Ingrid V Sils, Beau R Yurkevicius, Adam J Luippold, Alexander P Welles, Stephen R Muza
This study examined whether normobaric hypoxia (NH) treatment is more efficacious for sustaining high altitude (HA) acclimatization during re-introduction to altitude (RA) than no treatment at all. Seventeen sea level (SL) residents (age=23±6yrs; mean±SE) completed in the following order: 1)4d of SL testing, 2)12d of high altitude (HA) acclimatization at 4300m, 3)12d at SL post HA acclimatization (Post) where each received either NH (n=9;FiO2=0.122) or Sham (n=8;FiO2=0.207) treatment, and 4)24-h re-introduction to 4300m altitude (RA) in a hypobaric chamber...
July 13, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28704638/regulator-of-calcineurin-3-ameliorates-autoimmune-arthritis-by-suppressing-th17-cell-differentiation
#19
Jin-Sil Park, Jeong-Hee Jeong, Jae-Kyeong Byun, Mi-Ae Lim, Eun-Kyung Kim, Sung-Min Kim, Si-Young Choi, Sung-Hwan Park, Jun-Ki Min, Mi-La Cho
Regulator of calcineurin 3 (RCAN3), an endogenous regulator of the calcineurin-nuclear factor of activated T cells (NFAT) signaling pathway, inhibits the phosphatase activity of calcineurin, the nuclear translocation of NFAT, and the NFAT downstream pathway. To investigate the effects of RCAN3 on T-cell regulatory function and the development and progression of inflammatory arthritis, we studied the effects of RCAN3 transfection on regulation of Th17 cell differentiation in a murine T-lymphoma cell line and primary splenic CD4(+) T cells...
July 10, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28701032/bcl2-regulation-according-to-molecular-subtype-of-breast-cancer-by-analysis-of-the-cancer-genome-atlas-database
#20
Ki-Tae Hwang, Kwangsoo Kim, Ji Hyun Chang, Sohee Oh, Young A Kim, Jong Yoon Lee, Se Hee Jung, In Sil Choi
Purpose: We investigated BCL2 regulation across DNA, RNA, protein, and methylation status according to molecular subtype of breast cancer using The Cancer Genome Atlas (TCGA) database. Materials and Methods: We analyzed clinical and biological data on 1,096 breast cancers from the TCGA database. Biological data included reverse phase protein array (RPPA), mRNA sequencing (mRNA seq), mRNA microarray, methylation, copy number alteration linear, copy number alteration nonlinear, and mutation data...
July 4, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
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