Grace Salsbury, Emma L Cambridge, Zoe McIntyre, Mark J Arends, Natasha A Karp, Christopher Isherwood, Carl Shannon, Yvette Hooks, Ramiro Ramirez-Solis, David J Adams, Jacqueline K White, Anneliese O Speak
Iron homeostasis is a dynamic process that is tightly controlled to balance iron uptake, storage, and export. Reduction of dietary iron from the ferric to the ferrous form is required for uptake by solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (Slc11a2) into the enterocytes. Both processes are proton dependent and have led to the suggestion of the importance of acidic gastric pH for the absorption of dietary iron. Potassium voltage-gated channel subfamily E, member 2 (KCNE2), in combination with potassium voltage-gated channel, KQT-like subfamily, member 1 (KCNQ1), form a gastric potassium channel essential for gastric acidification...
December 2014: Experimental Hematology