keyword
MENU ▼
Read by QxMD icon Read
search

Arend

keyword
https://www.readbyqxmd.com/read/28196372/resilience-through-adaptation
#1
Guus A Ten Broeke, George A K van Voorn, Arend Ligtenberg, Jaap Molenaar
Adaptation of agents through learning or evolution is an important component of the resilience of Complex Adaptive Systems (CAS). Without adaptation, the flexibility of such systems to cope with outside pressures would be much lower. To study the capabilities of CAS to adapt, social simulations with agent-based models (ABMs) provide a helpful tool. However, the value of ABMs for studying adaptation depends on the availability of methodologies for sensitivity analysis that can quantify resilience and adaptation in ABMs...
2017: PloS One
https://www.readbyqxmd.com/read/28195166/effects-of-drought-on-leaf-carbon-source-and-growth-of-european-beech-are-modulated-by-soil-type
#2
Jian-Feng Liu, Matthias Arend, Wen-Juan Yang, Marcus Schaub, Yan-Yan Ni, Arthur Gessler, Ze-Ping Jiang, Andreas Rigling, Mai-He Li
Drought potentially affects carbon balance and growth of trees, but little is known to what extent soil plays a role in the trade-off between carbon gain and growth investment. In the present study, we analyzed leaf non-structural carbohydrates (NSC) as an indicator of the balance of photosynthetic carbon gain and carbon use, as well as growth of European beech (Fagus sylvatica L.) saplings, which were grown on two different soil types (calcareous and acidic) in model ecosystems and subjected to a severe summer drought...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28192439/regenotyper-detecting-mislabeled-samples-in-genetic-data
#3
Konrad Zych, Basten L Snoek, Mark Elvin, Miriam Rodriguez, K Joeri Van der Velde, Danny Arends, Harm-Jan Westra, Morris A Swertz, Gino Poulin, Jan E Kammenga, Rainer Breitling, Ritsert C Jansen, Yang Li
In high-throughput molecular profiling studies, genotype labels can be wrongly assigned at various experimental steps; the resulting mislabeled samples seriously reduce the power to detect the genetic basis of phenotypic variation. We have developed an approach to detect potential mislabeling, recover the "ideal" genotype and identify "best-matched" labels for mislabeled samples. On average, we identified 4% of samples as mislabeled in eight published datasets, highlighting the necessity of applying a "data cleaning" step before standard data analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28189001/functional-outcome-at-school-age-of-children-born-with-gastroschisis
#4
Chiara C M M Lap, Sandra W Bolhuis, Koenraad N J A Van Braeckel, Sijmen A Reijneveld, Gwendolyn T R Manten, Arend F Bos, Jan B F Hulscher
OBJECTIVE: We aimed to determine motor, cognitive and behavioural outcomes of school aged children born with gastroschisis compared to matched controls. STUDY DESIGN: We compared outcomes of 16 children born with gastroschisis treated at the University Medical Center Groningen, the Netherlands, between 1999 and 2006 with 32 controls matched for gender, gestational age, birth weight, and corrected for small for gestational age (SGA) and parental socioeconomic status (SES)...
February 8, 2017: Early Human Development
https://www.readbyqxmd.com/read/28186366/carbon-nanotube-quantum-dot-nanohybrids-coupling-with-single-particle-control-in-aqueous-solution
#5
Antonio Attanzio, Andrei Sapelkin, Felice Gesuele, Arend van der Zande, William P Gillin, Ming Zheng, Matteo Palma
A strategy is reported for the controlled assembly of organic-inorganic heterostructures consisting of individual single-walled carbon nanotubes (SWCNTs) selectively coupled to single semiconductor quantum dots (QDs). The assembly in aqueous solution was controlled towards the formation of monofunctionalized SWCNT-QD structures. Photoluminescence studies in solution, and on surfaces at the single nanohybrid level, showed evidence of electronic coupling between the two nanostructures. The ability to covalently couple heterostructures with single particle control is crucial for the design of novel QD-based optoelectronic and light-energy conversion devices...
February 10, 2017: Small
https://www.readbyqxmd.com/read/28183844/association-between-posterior-left-atrial-adipose-tissue-mass-and-atrial-fibrillation
#6
Alexander R van Rosendael, Aukelien C Dimitriu-Leen, Philippe J van Rosendael, Melissa Leung, Jeff M Smit, Antti Saraste, Juhani Knuuti, Rob J van der Geest, Britt W H van der Arend, Erik W van Zwet, Arthur J Scholte, Victoria Delgado, Jeroen J Bax
BACKGROUND: Epicardial adipose tissue located close to the atrial wall can change the electric conduction of the left atrium, potentially leading to atrial fibrillation (AF). The aim of this study was to assess whether an increased atrial adipose tissue mass posterior to the left atrium is related to AF independent of demographical and cardiovascular risk factors. METHODS AND RESULTS: Two hundred patients with AF and 200 patients without AF who underwent computed tomographic angiography were included...
February 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28177704/the-rab-gtpase-activating-protein-tbc1d1-is-critical-for-maintaining-normal-glucose-homeostasis-and-%C3%AE-cell-mass
#7
Sabina Paglialunga, Genevieve Simnett, Holly Robson, Monica Hoang, Renjitha Pillai, Alicia M Arkell, Jeremy A Simpson, Arend Bonen, Mark Huising, Jamie W Joseph, Graham P Holloway
TBC1D1, a Rab-GTPase activating protein, is a paralogue of AS160, and has been implicated in the canonical insulin-signaling cascade in peripheral tissues. More recently, TBC1D1 was identified in rat and human pancreatic islets, however the islet function of TBC1D1 remains not fully understood. We examined the role of TBC1D1 in glucose homeostasis and insulin secretion utilizing a rat knockout (KO) model. Chow-fed TBC1D1 KO rats had improved insulin action but impaired glucose-tolerance test (GTT) and a lower insulin response during an ipGTT compared to WT rats...
January 31, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28168740/decreased-biventricular-longitudinal-strain-shortly-after-congenital-heart-defect-surgery
#8
Jonne M de Boer, Irene M Kuipers, Liselotte M Klitsie, Nico A Blom, Arend D J Ten Harkel
OBJECTIVE: Impaired ventricular performance in patients who underwent surgery for congenital heart defect (CHD) may ultimately result in clinical heart failure. It is therefore important to regularly evaluate the left ventricular (LV) and right ventricular (RV) performance. We evaluated tissue Doppler imaging (TDI) and speckle tracking echocardiography (STE) before and after surgical correction of a CHD. STUDY DESIGN: Patients with CHD undergoing biventricular corrective surgery were included in this retrospective study...
February 6, 2017: Echocardiography
https://www.readbyqxmd.com/read/28167072/in-vivo-mr-spectroscopic-imaging-of-the-prostate-from-application-to-interpretation
#9
Nassim Tayari, Arend Heerschap, Tom W J Scheenen, Thiele Kobus
Proton magnetic resonance spectroscopic imaging ((1)H MRSI) enables non-invasive assessment of certain metabolites in the prostate gland. Several studies have demonstrated that this metabolic information, in combination with anatomical information from T2-weighted MR imaging significantly improves prostate cancer detection, localization and disease characterization. The technology of (1)H MRSI is continuously evolving with improvements of hardware and acquisition methods. Recently, (31)P and (13)C MRSI of the prostate have regained new interest after a dormant period of decades...
February 3, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28148826/prognostic-relevance-of-tumor-purity-and-tert-promoter-mutations-on-mgmt-promoter-methylation-in-glioblastoma
#10
Eva Schulze Heuling, Felix Knab, Josefine Radke, Eskil Eskilsson, Emmanuel Martinez-Ledesma, Arend Koch, Marcus Czabanka, Christoph Dieterich, Roel G Verhaak, Christoph Harms, Philipp Euskirchen
: Promoter methylation status of O-6-methylguanine-DNA methyltransferase (MGMT), a DNA repair enzyme, is a critical biomarker in glioblastoma multiforme (GBM) as treatment decisions and clinical trial inclusion rely on its accurate assessment. However, interpretation of results is complicated by poor inter-assay reproducibility as well as weak a correlation between methylation status and expression levels of MGMT. The present study systematically investigates the influence of tumor purity on tissue subjected to MGMT analysis...
February 1, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28146210/the-crispr-cas9-system-and-the-possibility-of-genomic-edition-for-cardiology
#11
Marcela Corso Arend, Jessica Olivaes Pereira, Melissa Medeiros Markoski
No abstract text is available yet for this article.
January 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28130057/value-of-re-interpretation-of-controversial-eegs-in-a-tertiary-epilepsy-clinic
#12
Johan B Arends, Inge van der Linden, Saskia C Ebus, Mariëtte H Debeij, Boudewijn W Gunning, Machiel J Zwarts
OBJECTIVE: Diagnostic value and efficacy of re-interpretation of previous EEGs in 100 patients admitted to a tertiary epilepsy center with EEG results conflicting with the clinical diagnosis after the first visit. METHODS: EEGs were reclassified. A matched control group was included to assess the efficiency of the re-interpretation process. Efficacy was assessed by questionnaires and costs as number of technician hours needed. RESULTS: In 85 patients the previous EEG conclusion was known...
December 29, 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28124378/fine-mapping-of-a-distal-chromosome-4-qtl-affecting-growth-and-muscle-mass-in-a-chicken-advanced-intercross-line
#13
S Lyu, D Arends, M K Nassar, G A Brockmann
In our previous research, QTL analysis in an F2 cross between the inbred New Hampshire (NHI) and White Leghorn (WL77) lines revealed a growth QTL in the distal part of chromosome 4. To physically reduce the chromosomal interval and the number of potential candidate genes, we performed fine mapping using individuals of generations F10 , F11 and F12 in an advanced intercross line that had been established from the initial F2 mapping population. Using nine single nucleotide polymorphism (SNP) markers within the QTL region for an association analysis with several growth traits from hatch to 20 weeks and body composition traits at 20 weeks, we could reduce the confidence interval from 26...
January 26, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28122742/ex-vivo-drug-response-profiling-detects-recurrent-sensitivity-patterns-in-drug-resistant-all
#14
Viktoras Frismantas, Maria Pamela Dobay, Anna Rinaldi, Joelle Tchinda, Samuel H Dunn, Joachim Kunz, Paulina Richter-Pechanska, Blerim Marovca, Orrin Pail, Silvia Jenni, Ernesto Diaz-Flores, Bill H Chang, Timothy J Brown, Robert H Collins, Sebastian Uhrig, Gnana P Balasubramanian, Obul R Bandapalli, Salome Higi, Sabrina Eugster, Pamela Voegeli, Mauro Delorenzi, Gunnar Cario, Mignon L Loh, Martin Schrappe, Martin Stanulla, Andreas E Kulozik, Martina U Muckenthaler, Vaskar Saha, Julie A Irving, Roland Meisel, Thomas Radimerski, Arend Von Stackelberg, Cornelia Eckert, Jeffrey W Tyner, Peter Horvath, Beat C Bornhauser, Jean-Pierre Bourquin
Drug sensitivity and resistance testing on diagnostic leukemia samples should provide important functional information to guide actionable target and biomarker discovery. We provide proof of concept data by profiling 60 drugs on 68 acute lymphoblastic leukemia (ALL) samples mostly from resistant disease in co-cultures on bone marrow stromal cells. Patient-derived xenografts retained the original pattern of mutations found in the matched patient material. Stromal co-culture did not prevent leukemia cell cycle activity, while a specific sensitivity profile to cell cycle related drugs identified samples with higher cell proliferation both in vitro and in vivo as leukemia xenografts...
January 25, 2017: Blood
https://www.readbyqxmd.com/read/28115232/identification-of-serological-biomarker-profiles-associated-with-total-joint-replacement-in-osteoarthritis-patients
#15
R H G P Arends, M A Karsdal, K M Verburg, C R West, A C Bay-Jensen, D S Keller
OBJECTIVE: Establish a biomarker panel associated with all-cause total joint replacement (TJR) through identification of patients with osteoarthritis (OA) who do or do not progress to TJR and investigate effects of nonsteroidal anti-inflammatory drugs (NSAIDs). DESIGN: Serum samples from patients enrolled in phase III trials of tanezumab who experienced TJR (n = 174) or matched patients who did not (n = 321) were analyzed for bone, cartilage, soft tissue, and inflammation markers...
January 21, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28111878/first-experience-of-the-aml-berlin-frankfurt-m%C3%A3-nster-group-in-pediatric-patients-with-standard-risk-acute-promyelocytic-leukemia-treated-with-arsenic-trioxide-and-all-trans-retinoid-acid
#16
Ursula Creutzig, Michael N Dworzak, Konrad Bochennek, Jörg Faber, Christian Flotho, Norbert Graf, Udo Kontny, Claudia Rossig, Irene Schmid, Arend von Stackelberg, Jans-Enno Mueller, Christine von Neuhoff, Dirk Reinhardt, Nils von Neuhoff
Recently, studies in adults with acute promyelocytic leukemia (APL) showed high cure rates in low-risk patients treated with all-trans retinoid acid (ATRA) and arsenic trioxide (ATO), while toxicities were significantly reduced compared to the standard treatment with ATRA and chemotherapy. Here we report about first experience with 11 pediatric patients with low-risk APL treated with ATRA and ATO. All patients stayed in molecular remission. All suffered from hyperleukocytosis. Two patients experienced reversible severe side effects...
January 23, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28106000/left-bundle-branch-block-after-sutureless-transcatheter-and-stented-biological-aortic-valve-replacement-for-aortic-stenosis
#17
Madelien V Regeer, Lisanne R Merkestein, Arend de Weger, Vasileios Kamperidis, Frank van der Kley, Philippe J van Rosendael, Nina Ajmone Marsan, Robert J M Klautz, Martin J Schalij, Jeroen J Bax, Victoria Delgado
AIMS: Conventional aortic valve replacement (AVR), sutureless AVR (su-AVR) and transcatheter aortic valve implantation (TAVI) for severe aortic stenosis (AS) are associated with conduction abnormalities. The aim of the present study was to assess the incidence of left bundle branch block (LBBB) after su-AVR and TAVI, in comparison to conventional AVR. METHODS AND RESULTS: A total of 501 patients (mean age 74±8 years, 53% male) without preoperative cardiac conduction disturbances who underwent AVR or TAVI were included in the study...
January 20, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28104527/b7-h3-targeted-212-pb-radioimmunotherapy-of-ovarian-cancer-in-preclinical-models
#18
Benjamin B Kasten, Rebecca C Arend, Ashwini A Katre, Harrison Kim, Jinda Fan, Soldano Ferrone, Kurt R Zinn, Donald J Buchsbaum
INTRODUCTION: Novel therapies that effectively kill both differentiated cancer cells and cancer initiating cells (CICs), which are implicated in causing chemotherapy-resistance and disease recurrence, are needed to reduce the morbidity and mortality of ovarian cancer. These studies used monoclonal antibody (mAb) 376.96, which recognizes a B7-H3 epitope expressed on ovarian cancer cells and CICs, as a carrier molecule for targeted α-particle radioimmunotherapy (RIT) in preclinical models of human ovarian cancer...
January 10, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28089983/detailed-analysis-of-the-articular-domain-in-patients-with-primary-sj%C3%A3-gren-syndrome
#19
Rada V Moerman, Suzanne Arends, Petra M Meiners, Arjan Vissink, Frederik K L Spijkervet, Frans G M Kroese, Elisabeth Brouwer, Hendrika Bootsma
OBJECTIVE: We used the 28-joint Disease Activity Score (DAS28) and the European League Against Rheumatism Sjögren's Syndrome Disease Activity Index (ESSDAI) articular domain to assess the effect of rituximab (RTX) and abatacept (ABA) on articular involvement in primary Sjögren syndrome (pSS). METHODS: Patients with pSS treated with RTX (n = 18) or ABA (n = 13) and having a DAS28 erythrocyte sedimentation rate (ESR)/C-reactive protein (CRP) level ≥ 3.2 at baseline were selected...
January 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28081150/the-association-of-birth-weight-and-infant-growth-with-energy-balance-related-behavior-a-systematic-review-and-best-evidence-synthesis-of-human-studies
#20
Arend W van Deutekom, Mai J M Chinapaw, Elise P Jansma, Tanja G M Vrijkotte, Reinoud J B J Gemke
BACKGROUND: Suboptimal prenatal and early postnatal growths are associated with obesity in later life, but the underlying mechanisms are unknown. The aim of this study was to systematically review the literature that reports on the longitudinal association of (i) birth size or (ii) infant growth with later (i) energy intake, (ii) eating behaviors, (iii) physical activity or (iv) sedentary behavior in humans. METHODS: A comprehensive search of MEDLINE, EMBASE, PsycINFO and The Cochrane Library was conducted to identify relevant publications...
2017: PloS One
keyword
keyword
68242
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"