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https://www.readbyqxmd.com/read/29219817/donor-derived-tuberculosis-via-orthotopic-liver-transplantation
#1
B N Ruijter, A K S van Wijngaarden, B van Hoek, M Mensen, D van Soolingen, S M Arend
We present a case of donor-derived tuberculosis after liver transplantation, in which the donor origin of the Mycobacterium tuberculosis isolate was made most likely by DNA fingerprinting. Screening for latent tuberculosis of transplant donors originating from high endemic areas with an ex-vivo interferon-gamma release assay should be considered.
November 2017: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/29217468/availability-of-hepatitis-c-diagnostics-and-therapeutics-in-european-and-eurasia-countries
#2
Hakan Leblebicioglu, Joop E Arends, Resat Ozaras, Giampaolo Corti, Lurdes Santos, Christoph Boesecke, Andrew Ustianowski, Ann-Sofi Duberg, Simona Ruta, Nermin N Salkic, Petr Husa, Ivana Lazarevic, Juan A Pineda, Natalia Yurievna Pshenichnaya, Tengiz Tsertswadze, Mojca Matičič, Edmond Puca, Gulzhan Abuova, Judit Gervain, Ramin Bayramli, Salih Ahmeti, Mairi Koulentaki, Badreddine Kilani, Adriana Vince, Francesco Negro, Mustafa Sunbul, Dominique Salmon
BACKGROUND: Treatment with direct acting antiviral agents (DAAs) has provided sustained virological response rates in >95% of patients with chronic hepatitis C virus (HCV) infection. However treatment is costly and market access, reimbursement and governmental restrictions differ among countries. We aimed to analyze these differences among European and Eurasian countries. METHODS: A survey including 20-item questionnaire was sent to experts in viral hepatitis...
December 4, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29217367/response-to-the-comments-on-direct-quantitative-measurement-of-the-kinetics-of-hla-specific-antibody-interactions-with-isolated-hla-proteins
#3
Sunil Daga, Harry Moyse, David Briggs, David Lowe, Neil Evans, James Jones, Rico Buchli, Curtis McMurtrey, Arend Mulder, William Hildebrand, Frans Claas, Robert Higgins, Daniel A Mitchell, Daniel Zehnder
No abstract text is available yet for this article.
December 4, 2017: Human Immunology
https://www.readbyqxmd.com/read/29210268/correction-to-limits-of-carrier-diffusion-in-n-type-and-p-type-ch3nh3pbi3-perovskite-single-crystals
#4
Octavi E Semonin, Giselle A Elbaz, Daniel B Straus, Trevor D Hull, Daniel W Paley, Arend M Van der Zande, James C Hone, Ioannis Kymissis, Cherie R Kagan, Xavier Roy, Jonathan S Owen
No abstract text is available yet for this article.
December 6, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29201242/selective-photooxidation-reactions-using-water-soluble-anthraquinone-photocatalysts
#5
Wuyuan Zhang, Jenő Gacs, Isabel W C E Arends, Frank Hollmann
The aerobic organocatalytic oxidation of alcohols was achieved by using water-soluble sodium anthraquinone sulfonate. Under visible-light activation, this catalyst mediated the aerobic oxidation of alcohols to aldehydes and ketones. The photo-oxyfunctionalization of alkanes was also possible under these conditions.
October 23, 2017: ChemCatChem
https://www.readbyqxmd.com/read/29200095/widespread-spontaneous-hyperproliferation-melanosis-and-melanoma-in-hgf-cdk4r24c-mice
#6
Louise van der Weyden, Mark J Arends, Thomas Brenn, Thomas Tuting, David J Adams
No abstract text is available yet for this article.
December 1, 2017: Melanoma Research
https://www.readbyqxmd.com/read/29199021/an-integrated-systems-genetics-and-omics-toolkit-to-probe-gene-function
#7
Hao Li, Xu Wang, Daria Rukina, Qingyao Huang, Tao Lin, Vincenzo Sorrentino, Hongbo Zhang, Maroun Bou Sleiman, Danny Arends, Aaron McDaid, Peiling Luan, Naveed Ziari, Laura A Velázquez-Villegas, Karim Gariani, Zoltan Kutalik, Kristina Schoonjans, Richard A Radcliffe, Pjotr Prins, Stephan Morgenthaler, Robert W Williams, Johan Auwerx
Identifying genetic and environmental factors that impact complex traits and common diseases is a high biomedical priority. Here, we developed, validated, and implemented a series of multi-layered systems approaches, including (expression-based) phenome-wide association, transcriptome-/proteome-wide association, and (reverse-) mediation analysis, in an open-access web server (systems-genetics.org) to expedite the systems dissection of gene function. We applied these approaches to multi-omics datasets from the BXD mouse genetic reference population, and identified and validated associations between genes and clinical and molecular phenotypes, including previously unreported links between Rpl26 and body weight, and Cpt1a and lipid metabolism...
November 30, 2017: Cell Systems
https://www.readbyqxmd.com/read/29198910/performance-of-xpert-mtb-rif-ultra-a-matter-of-dead-or-alive
#8
Sandra M Arend, Dick van Soolingen
No abstract text is available yet for this article.
November 30, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29196623/evolving-autonomous-learning-in-cognitive-networks
#9
Leigh Sheneman, Arend Hintze
There are two common approaches for optimizing the performance of a machine: genetic algorithms and machine learning. A genetic algorithm is applied over many generations whereas machine learning works by applying feedback until the system meets a performance threshold. These methods have been previously combined, particularly in artificial neural networks using an external objective feedback mechanism. We adapt this approach to Markov Brains, which are evolvable networks of probabilistic and deterministic logic gates...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29196502/identifying-the-localization-and-exploring-a-functional-role-for-gprc5c-in-the-kidney
#10
Premraj Rajkumar, Boyoung Cha, Jianyi Yin, Lois J Arend, Teodor G Păunescu, Yoshio Hirabayashi, Mark Donowitz, Jennifer L Pluznick
The investigation of orphan GPCRs (GPRs) has the potential to uncover novel insights into whole animal physiology. In this study, our goal was to determine the renal localization of Gprc5c, a receptor that we previously reported to be highly expressed in murine whole kidney, and to examine physiologic parameters in Gprc5c knockout (KO) mice to gain insight into function. Gprc5c localized to the apical membrane of renal proximal tubules (PTs) in mice, rats, and humans. With the comparison of Gprc5c wild-type (WT) and KO mice, we found that Gprc5c KO mice have altered acid-base homeostasis...
December 1, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29194939/management-of-drug-interactions-with-direct-acting-antivirals-in-dutch-hiv-hepatitis-c-virus-coinfected-patients-adequate-but-not-perfect
#11
E J Smolders, C Smit, Ctmm de Kanter, Asm Dofferhoff, J E Arends, K Brinkman, B Rijnders, M van der Valk, P Reiss, D M Burger
OBJECTIVES: Direct-acting antivirals (DAAs) for treatment of chronic hepatitis C virus (HCV) infection can cause drug-drug interactions (DDIs) with combination antiretroviral therapy (cART) and non-cART co-medication. We mapped how physicians manage DDIs between DAAs and co-medication and analysed treatment outcomes. METHODS: Data were prospectively collected as part of the ATHENA HIV observational cohort and retrospectively analysed. Dutch patients with HIV/HCV coinfection who initiated treatment with DAAs between January 2015 and May 2016 were included...
December 1, 2017: HIV Medicine
https://www.readbyqxmd.com/read/29193007/outcome-of-relapse-after-allogeneic-hsct-in-children-with-all-enrolled-in-the-all-sct-2003-2007-trial
#12
Michaela Kuhlen, Andre M Willasch, Jean-Hugues Dalle, Jacek Wachowiak, Isaac Yaniv, Marianne Ifversen, Petr Sedlacek, Tayfun Guengoer, Peter Lang, Peter Bader, Sabina Sufliarska, Adriana Balduzzi, Brigitte Strahm, Irene von Luettichau, Jessica I Hoell, Arndt Borkhardt, Thomas Klingebiel, Martin Schrappe, Arend von Stackelberg, Evgenia Glogova, Ulrike Poetschger, Roland Meisel, Christina Peters
Relapse remains the major cause of treatment failure in children with high-risk acute lymphoblastic leukaemia (ALL) undergoing allogeneic haematopoietic stem-cell transplantation (allo-SCT). Prognosis is considered dismal but data on risk factors and outcome are lacking from prospective studies. We analysed 242 children with recurrence of ALL after first allo-SCT enrolled in the Berlin-Frankfurt-Munster (BFM) ALL-SCT-BFM 2003 and ALL-SCT-BFM international 2007 studies. Median time from allo-SCT to relapse was 7·7 months; median follow-up from relapse after allo-SCT until last follow-up was 3·4 years...
November 28, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/29191126/intravesical-radiofrequency-induced-hyperthermia-enhances-mitomycin-c-accumulation-in-tumour-tissue
#13
F Johannes P van Valenberg, Antoine G van der Heijden, Rianne J M Lammers, Johannes Falke, Tom J H Arends, Egbert Oosterwijk, J Alfred Witjes
INTRODUCTION: Non-muscle invasive bladder cancer (NMIBC) is a highly recurrent disease with potential progression to muscle invasive disease despite the standard bladder instillations with mitomycin C (MMC) or Bacille Calmette-Guérin immunotherapy. Therefore, alternatives such as radiofrequency-induced chemohyperthermia (RF-CHT) with MMC are being investigated. The mechanism explaining the efficacy of RF-CHT is only partly understood. We examined whether RF-CHT results in higher MMC tissue concentrations as compared to cold MMC instillation...
December 1, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29186365/high-treatment-uptake-in-hiv-hcv-coinfected-patients-after-unrestricted-access-to-direct-acting-antivirals-in-the-netherlands
#14
Anne Boerekamps, Astrid M Newsum, Colette Smit, Joop E Arends, Clemens Richter, Peter Reiss, Bart J A Rijnders, Kees Brinkman, Marc van der Valk
Background: The Netherlands has provided unrestricted access to direct-acting antivirals (DAAs) since November 2015. We analyzed the nationwide HCV treatment uptake among HIV/HCV-coinfected patients. Methods: Data were obtained from the ATHENA HIV observational cohort in which >98% of HIV-infected patients ever registered since 1998 are included. Patients were included if they ever had 1 positive HCV RNA, did not spontaneously clear and were known to still be in care...
November 23, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29186320/declining-hcv-incidence-in-dutch-hiv-positive-men-who-have-sex-with-men-after-unrestricted-access-to-hcv-therapy
#15
Anne Boerekamps, Guido E Van den Berk, Lauw N Fanny, Eliane M Leyten, Marjo E Van Kasteren, Arne van Eeden, Dirk Posthouwer, Mark A Claassen, Anton S Dofferhoff, Dominique W M Verhagen, Wouter F Bierman, Kamilla D Lettinga, Frank P Kroon, Corine E Delsing, Paul H Groeneveld, Robert Soetekouw, Edgar J Peters, Sebastiaan J Hullegie, Stephanie Popping, David A M C Van de Vijver, Charles A Boucher, Joop E Arends, Bart J Rijnders
Background: Direct acting antivirals (DAA) cure 95% of patients infected with hepatitis C (HCV). Modeling studies predict that universal HCV treatment will lead to a decrease in the incidence of new infections but real-life data are lacking. The incidence of HCV among Dutch HIV-positive men who have sex with men (MSM) has been high for >10 years. In 2015 DAA became available to all Dutch HCV patients and resulted in a rapid treatment uptake in HIV-positive MSM. We assessed whether this uptake was followed by a decrease in the incidence of HCV infections...
November 23, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29184529/the-changing-role-of-health-care-professionals-in-nursing-homes-a-systematic-literature-review-of-a-decade-of-change
#16
Arend R van Stenis, Jessica van Wingerden, Isolde Kolkhuis Tanke
Although the role of health care professionals is known to have changed over the last years, few formal efforts have been made to examine this change through means of a scientific review. Therefore, the goal of this paper was to investigate the changing role of health care professionals in nursing homes, as well as the conditions that make this change possible. A systematic review of health care literature published in the last decade (2007-2017) was utilized to address these goals. Our findings suggest that although health care in nursing homes is shifting from task-oriented care to relation-oriented care (e...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29183843/the-moca-basic-is-not-a-reliable-screening-tool-for-cognitive-decline-in-cart-receiving-hiv-patients-in-rural-south-africa
#17
C S Hakkers, A J M Beunders, M H M Ensing, R E Barth, S Boelema, W L J Devillé, H A Tempelman, R A Coutinho, I M Hoepelman, J E Arends, M J E van Zandvoort
BACKGROUND: HIV Associated Neurocognitive Disorders (HAND) is a frequently occurring comorbidity in HIV-infected (HIV+) patients diagnosed by means of a NeuroPsychological Assessment (NPA). Due to the magnitude of the HIV+ population in sub-Saharan Africa, easy-to-use cognitive screening tools are mandatory. METHODS: cross-sectional clinical trial in 44 HIV+ patients (stable cART) and 73 HIV-negative (HIV-) controls completing an NPA, the International HIV Dementia Scale (IHDS) and a culturally appropriate cognitive screening tool; the MoCA Basic (MoCa-B)...
November 25, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29166238/shiga-toxin-producing-e-coli-infections-associated-with-flour
#18
Samuel J Crowe, Lyndsay Bottichio, Lauren N Shade, Brooke M Whitney, Nereida Corral, Beth Melius, Katherine D Arends, Danielle Donovan, Jolianne Stone, Krisandra Allen, Jessica Rosner, Jennifer Beal, Laura Whitlock, Anna Blackstock, June Wetherington, Lisa A Newberry, Morgan N Schroeder, Darlene Wagner, Eija Trees, Stelios Viazis, Matthew E Wise, Karen P Neil
BACKGROUND: In 2016, a multijurisdictional team investigated an outbreak of Shiga toxin-producing Escherichia coli (STEC) serogroup O121 and O26 infections linked to contaminated flour from a large domestic producer. METHODS: A case was defined as infection with an outbreak strain in which illness onset was between December 21, 2015, and September 5, 2016. To identify exposures associated with the outbreak, outbreak cases were compared with non-STEC enteric illness cases, matched according to age group, sex, and state of residence...
November 23, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29165862/an-assessment-of-an-australasian-pathway-for-the-introduction-of-transanal-total-mesorectal-excision-tatme
#19
Sarah C Abbott, Andrew R L Stevenson, Stephen W Bell, David Clark, Arend Merrie, Julian Hayes, Shanthan Ganesh, Alexander G Heriot, Satish K Warrier
AIM: To evaluate the use of a pathway for the introduction of transanal total mesorectal excision (taTME) into Australia and New Zealand. METHOD: A pathway for surgeons with an appropriate level of specialist training and baseline skillset was initiated amongst colorectal surgeons; it includes an intensive course, a series of proctored cases and ongoing contribution to audit. Data were collected for patients who had taTME, for benign and malignant conditions, undertaken by the initial adopters of the technique...
November 22, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29160917/visualization-of-calcium-phosphate-cement-in-teeth-by-zero-echo-time-1-h-mri-at-high-field
#20
Weiqiang Dou, Simone Mastrogiacomo, Andor Veltien, Hamdan S Alghamdi, X Frank Walboomers, Arend Heerschap
(1) H magnetic resonance imaging (MRI) by a zero echo time (ZTE) sequence is an excellent method to image teeth. Calcium phosphate cement (CPC) materials are applied in the restoration of tooth lesions, but it has not yet been investigated whether they can be detected by computed tomography (CT) or MRI. The aim of this study was to optimize high-field ZTE imaging to enable the visualization of a new CPC formulation implanted in teeth and to apply this in the assessment of its decomposition in vivo. CPC was implanted in three human and three goat teeth ex vivo and in three goat teeth in vivo...
November 21, 2017: NMR in Biomedicine
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