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https://www.readbyqxmd.com/read/28230321/disruption-of-genes-involved-in-corvet-complex-leads-to-enhanced-secretion-of-heterologous-carboxylesterase-only-in-protease-deficient-pichia-pastoris
#1
Lukas Marsalek, Clemens Gruber, Friedrich Altmann, Markus Aleschko, Diethard Mattanovich, Brigitte Gasser, Verena Puxbaum
The methylotrophic yeast Pichia pastoris (Komagataella spp.) is a popular microbial host for the production of recombinant proteins. Previous studies have shown that mis-sorting to the vacuole can be a bottleneck during production of recombinant secretory proteins in yeast, however, no information was available for P. pastoris. In this work we have therefore generated vps (vacuolar protein sorting) mutant strains disrupted in genes involved in the CORVET tethering complex at the early stages of endosomal sorting...
February 23, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28228427/myocardial-infarction-risk-after-discontinuation-of-thienopyridine-therapy-in-the-randomized-dapt-study
#2
Ada C Stefanescu Schmidt, Dean J Kereiakes, Donald E Cutlip, Robert W Yeh, Ralph B D'Agostino, Joseph M Massaro, Wen-Hua Hsieh, Laura Mauri
Background -Thienopyridine plus aspirin beyond one year after coronary stenting (PCI) reduces myocardial infarction (MI) risk and increases bleeding risk compared with aspirin alone. The hazard associated with late thienopyridine discontinuation and risk factors for MI after discontinuation are poorly defined. Methods -In the Dual Antiplatelet Therapy (DAPT) Study, after PCI and 12 months of thienopyridine (clopidogrel or prasugrel) plus aspirin, eligible patients remained on aspirin and were randomized to continued thienopyridine vs...
February 22, 2017: Circulation
https://www.readbyqxmd.com/read/28227064/energy-based-metrics-for-laparoscopic-skills-assessment
#3
Behnaz Poursartip, Marie-Eve LeBel, Rajni V Patel, Michael D Naish, Ana Luisa Trejos, Behnaz Poursartip, Marie-Eve LeBel, Rajni V Patel, Michael D Naish, Ana Luisa Trejos, Rajni V Patel, Michael D Naish, Marie-Eve LeBel, Ana Luisa Trejos, Behnaz Poursartip
The growing popularity of minimally invasive surgery (MIS) can be attributed to its advantages, which include reduced post-operative pain, a shorter hospital stay, and faster recovery. However, MIS requires extensive training for surgeons to become experts in their field of practice. Different assessment methods have been proposed for evaluating the performance of surgeons and residents on surgical simulators. Nonetheless, optimal objective performance measures are still lacking. In this study, three metrics for minimally invasive skills assessment are proposed based on energy expenditure: work, potential energy and kinetic energy...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226608/heart-beat-characterization-from-ballistocardiogram-signals-using-extended-functions-of-multiple-instances
#4
Changzhe Jiao, Princess Lyons, Alina Zare, Licet Rosales, Marjorie Skubic, Changzhe Jiao, Princess Lyons, Alina Zare, Licet Rosales, Marjorie Skubic, Princess Lyons, Alina Zare, Changzhe Jiao, Marjorie Skubic, Licet Rosales
A multiple instance learning (MIL) method, extended Function of Multiple Instances (eFUMI), is applied to ballistocardiogram (BCG) signals produced by a hydraulic bed sensor. The goal of this approach is to learn a personalized heartbeat "concept" for an individual. This heartbeat concept is a prototype (or "signature") that characterizes the heartbeat pattern for an individual in ballistocardiogram data. The eFUMI method models the problem of learning a heartbeat concept from a BCG signal as a MIL problem...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225638/laparoscopic-resection-of-pancreatic-tumors-in-children-results-of-a-multicentric-survey
#5
Ciro Esposito, Pascal De Lagausie, Maria Escolino, Amulya Saxena, George W Holcomb, Alessandro Settimi, Francois Becmeur, David van der Zee
AIM: This study aimed to report the results of a multicentric survey about laparoscopic treatment of pancreatic tumors in children. MATERIALS AND METHODS: The data of patients operated using minimally invasive surgery (MIS) for a pancreatic tumor in 5 International centers of Pediatric Surgery in the last 5 years were retrospectively reviewed. We recorded data relating to the clinical presentation, diagnostic evaluation, surgical technique, and outcome. RESULTS: Fifteen patients (average age 2...
February 22, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28224313/sexual-stereotypes-ascribed-to-black-men-who-have-sex-with-men-an-intersectional-analysis
#6
Sarah K Calabrese, Valerie A Earnshaw, Manya Magnus, Nathan B Hansen, Douglas S Krakower, Kristen Underhill, Kenneth H Mayer, Trace S Kershaw, Joseph R Betancourt, John F Dovidio
Sexual stereotypes may adversely affect the health of Black men who have sex with men (MSM). Greater understanding of the nature and nuances of these stereotypes is needed. This online, survey-based study used an inductive, intersectional approach to characterize the sexual stereotypes ascribed to Black MSM by the U.S. general public, their distinctiveness from those ascribed to Black men and MSM in general, and their relative prototypicality as compared to dominant subgroups. Members of the public, recruited in 2014-2015, were randomly assigned to survey conditions that varied systematically by race (Black, White, or unspecified) and sexual orientation (gay, heterosexual, or unspecified) of a designated social group...
February 21, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28223195/cell-stress-response-to-two-different-types-of-polymer-coated-cobalt-ferrite-nanoparticles
#7
Jasna Lojk, Klemen Strojan, Katarina Miš, Boštjan Vladimir Bregar, Iva Hafner Bratkovič, Maruša Bizjak, Sergej Pirkmajer
Potential nanoparticle (NP) toxicity is one of crucial problems that limit the applicability of NPs. When designing NPs for biomedical and biotechnological applications it is thus important to understand the mechanisms of their toxicity. In this study, we analysed the stress responses of previously designed polyacrylic acid (PAA) and polyethylenimine (PEI) coated NPs on primary human myoblasts (MYO) and B16 mouse melanoma cell line. Negatively charged PAA did not induce cell toxicity, reactive oxygen species (ROS) or activate the transcription factor NF-κB in either cell line even at high concentrations (100μg/ml)...
February 18, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28223182/minimally-invasive-surgical-staging-in-early-stage-ovarian-carcinoma-a-systematic-review-and-meta-analysis
#8
REVIEW
Giorgio Bogani, Chiara Borghi, Umberto Leone Roberti Maggiore, Antonino Ditto, Mauro Signorelli, Fabio Martinelli, Valentina Chiappa, Carlos Lopez, Ilaria Sabatucci, Cono Scaffa, Alice Indini, Simone Ferrero, Domenica Lorusso, Francesco Raspagliesi
Few studies investigated the efficacy and safety of minimally invasive surgery (MIS) for the treatment of early stage epithelial ovarian cancer (eEOC). In this context, we aimed to review the current evidence comparing laparoscopy and laparotomic approach for staging procedures in eEOC This systematic review was registered in the International Prospective Register of Systematic Review. Overall, 3,065 patients were included: 1,450 undergoing laparoscopy and 1,615 undergoing laparotomic staging. Patients undergoing laparoscopy experienced a longer (but not statistically significant) operative time (WMD: 28...
February 18, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28222963/performance-of-subjective-global-assessment-and-malnutrition-inflammation-score-for-monitoring-the-nutritional-status-of-older-adults-on-hemodialysis
#9
Fernanda Santin, Juliana Rodrigues, Flávia Barbosa Brito, Carla Maria Avesani
BACKGROUND & AIMS: Studies assessing the performance of 7-point subjective global assessment (7p-SGA) and malnutrition inflammation score (MIS) to assess longitudinal changes in nutritional status are lacking. Thus, we aimed to investigate whether longitudinal changes in 7p-SGA and MIS were associated with changes in objective parameters of nutritional status, as well as to evaluate the prognostic value of 7p-SGA and MIS on hospitalization events. METHODS: One hundred and four patients aged ≥60 years (70...
February 3, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28222094/housing-improvements-and-malaria-risk-in-sub-saharan-africa-a-multi-country-analysis-of-survey-data
#10
Lucy S Tusting, Christian Bottomley, Harry Gibson, Immo Kleinschmidt, Andrew J Tatem, Steve W Lindsay, Peter W Gething
BACKGROUND: Improvements to housing may contribute to malaria control and elimination by reducing house entry by malaria vectors and thus exposure to biting. We tested the hypothesis that the odds of malaria infection are lower in modern, improved housing compared to traditional housing in sub-Saharan Africa (SSA). METHODS AND FINDINGS: We analysed 15 Demographic and Health Surveys (DHS) and 14 Malaria Indicator Surveys (MIS) conducted in 21 countries in SSA between 2008 and 2015 that measured malaria infection by microscopy or rapid diagnostic test (RDT)...
February 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28219316/from-disorder-to-mis-order-structural-aspects-of-pathogenic-oligomerization-in-conformational-diseases
#11
Chin Pang Benny Yiu, Yu Wai Chen
Proteins implicated in neurological conformational diseases contain substantial amounts of "intrinsic disorder". These native monomeric functional states may transit into some oligomeric states that have high β-sheet contents and seed the formation of insoluble amyloid fibrils. The prevailing view is that these "toxic" oligomers should be targeted for drug development. Here, an overview of the diseases was presented, within the general framework of the oligomerization of intrinsically disordered proteins. These systems pose some specific challenges to structural studies: the toxic oligomers are transient, low in concentration, and often need to be studied in a heterogeneous environment...
February 20, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28218370/incidence-of-heterotopic-ossification-in-minimally-invasive-short-stem-tha-using-the-modified-anterolateral-approach
#12
Karl P Kutzner, Marlene Hechtner, Dominik Pfeil, Philipp Rehbein, Mark P Kovacevic, Michael Schneider, Werner Siebert, Joachim Pfeil
INTRODUCTION: Heterotopic ossification (HO) is known to be a common complication after total hip arthroplasty (THA). The minimal invasive (MIS) modified anterolateral approach has become popular in combination with a short stem. We analysed the incidence of HO following short-stem THA using this approach in combination with a postoperative administration of nonsteroidal anti-inflammatory drugs (NSAIDs). MATERIALS AND METHODS: 216 short stems were implanted in 162 patients...
February 8, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28218281/ubiquitination-and-dynactin-regulate-tmepai-lysosomal-trafficking
#13
Shenheng Luo, Lei Jing, Tian Zhao, Yuyin Li, Zhenxing Liu, Aipo Diao
The transmembrane prostate androgen-induced protein (TMEPAI) has been reported to be elevated in various tumor cells, is localized to the lysosome and promotes lysosome stability. The molecular mechanism of TMEPAI trafficking however to the lysosome is unknown. Here we report that clathrin and CI-M6PR mediate TMEPAI transport from the Golgi directly into the endo-lysosomal pathway. TMEPAI is ubiquitinated at its C-terminal region and ubiquitination modification of TMEPAI is a signal for its lysosomal trafficking...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28216279/outcomes-and-drug-costs-of-sunitinib-regimens-for-metastatic-renal-cell-carcinoma-a-provincial-population-based-study
#14
Aleksi Suo, Urooj Iqbal, June Lim, Chel Lee, Kathy Gesy, Nayyer Iqbal, Tahir Abbas
BACKGROUND: Conventional sunitinib dosing in metastatic renal cell carcinoma (mRCC) administers 50 mg daily on a 4 weeks on/2 weeks off (4/2) schedule. Not all patients tolerate this regimen and many undergo modifications to schedule, dose, or both. MATERIAL AND METHODS: All patients with mRCC treated with sunitinib by the Saskatchewan Cancer Agency between January 1, 2006, and January 1, 2013, were included. Regimens were categorized as standard intermittent dosing (SID), modified intermittent schedule (MIS), modified intermittent dosing (MID), combination of modified schedule and dosing (MSD), or continuous dosing (CD)...
February 1, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28213694/erratum-to-first-clinical-results-of-minimally-invasive-vector-lumbar-interbody-fusion-mis-vlif-in-spondylodiscitis-and-concomitant-osteoporosis-a-technical-note
#15
Bernhard Rieger, Hongzhen Jiang, Daniel Ruess, Clemens Reinshagen, Marek Molcanyi, Jozef Zivcak, Huaiyu Tong, Gabriele Schackert
No abstract text is available yet for this article.
February 17, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28212593/micrornas-and-endometriosis-distinguishing-drivers-from-passengers-in-disease-pathogenesis
#16
Warren B Nothnick
Endometriosis is a disease common in women of reproductive age, characterized by pelvic pain and infertility. Despite its prevalence, the factors and mechanisms which contribute to the development and survival of ectopic lesions remain uncertain. MicroRNAs (miRNAs) are small RNA molecules that regulate posttranscriptional gene regulation which have been proposed to contribute to the pathogenesis of many diseases including that of endometriosis. This review summarizes the results of initial studies describing differentially expressed miRNAs between endometriotic lesion tissue and eutopic endometrium...
February 17, 2017: Seminars in Reproductive Medicine
https://www.readbyqxmd.com/read/28210864/pharmacy-benefit-management-companies-do-they-create-value-in-the-us-healthcare-system
#17
Alan Lyles
Pharmacy benefit management companies (PBMs) perform functions in the US market-based healthcare system that may be performed by public agencies or quasi-public institutions in other nations. By aggregating lives covered under their many individual contracts with payers, PBMs have formidable negotiating power. They influence pharmaceutical insurance coverage, design the terms of coverage in a plan's drug benefit, and create competition among providers for inclusion in a plan's network. PBMs have, through intermediation, the potential to secure lower drug prices and to improve rational prescribing...
February 16, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28209030/effects-of-annealing-ambient-on-the-characteristics-of-laalo3-films-grown-by-atomic-layer-deposition
#18
Lu Zhao, Hong-Xia Liu, Xing Wang, Chen-Xi Fei, Xing-Yao Feng, Yong-Te Wang
We investigated the effects of different annealing ambients on the physical and electrical properties of LaAlO3 films grown by atomic layer deposition. Post-grown rapid thermal annealing (RTA) was carried out at 600 °C for 1 min in vacuum, N2, and O2, respectively. It was found that the chemical bonding states at the interfacial layers (ILs) between LaAlO3 films and Si substrate were affected by the different annealing ambients. The formation of IL was enhanced during the RTA process, resulting in the decrease of accumulation capacitance, especially in O2 ambient...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28207762/minimally-invasive-procedure-reduces-adjacent-segment-degeneration-and-disease-new-benefit-based-global-meta-analysis
#19
Xiao-Chuan Li, Chun-Ming Huang, Cheng-Fan Zhong, Rong-Wei Liang, Shao-Jian Luo
OBJECTIVE: Adjacent segment pathology (ASP) is a common complication presenting in patients with axial pain and dysfunction, requiring treatment or follow-up surgery. However, whether minimally invasive surgery (MIS), including MIS transforaminal / posterior lumbar interbody fusion (MIS-TLIF/PLIF) decreases the incidence rate of ASP remains unknown. The aim of this meta-analysis was to compare the incidence rate of ASP in patients undergoing MIS versus open procedures. METHODS: This systematic review was undertaken by following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement...
2017: PloS One
https://www.readbyqxmd.com/read/28207678/mexican-american-college-men-s-mis-understandings-about-hpv-and-cervical-cancer
#20
Tiffany A Schiffner, Lydia P Buki, Raha F Sabet
Latinas have disproportionally high rates of cervical cancer in part due to their reliance on Latino partners to make sexual health decisions, their limited knowledge about human papillomavirus (HPV), and inconsistent Pap smear screening behaviors. In this qualitative study, we examined the sexual health beliefs of Latino college men regarding HPV. Participants included 6 Mexican American college students from a large Midwestern university. We conducted 18 in-depth individual interviews about men's beliefs, attitudes, and knowledge about HPV...
April 2017: Family & Community Health
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