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https://www.readbyqxmd.com/read/28434198/eukaryotic-diversity-in-late-pleistocene-marine-sediments-around-a-shallow-methane-hydrate-deposit-in-the-japan-sea
#1
M Kouduka, A S Tanabe, S Yamamoto, K Yanagawa, Y Nakamura, F Akiba, H Tomaru, H Toju, Y Suzuki
Marine sediments contain eukaryotic DNA deposited from overlying water columns. However, a large proportion of deposited eukaryotic DNA is aerobically biodegraded in shallow marine sediments. Cold seep sediments are often anaerobic near the sediment-water interface, so eukaryotic DNA in such sediments is expected to be preserved. We investigated deeply buried marine sediments in the Japan Sea, where a methane hydrate deposit is associated with cold seeps. Quantitative PCR analysis revealed the reproducible recovery of eukaryotic DNA in marine sediments at depths up to 31...
April 23, 2017: Geobiology
https://www.readbyqxmd.com/read/28430827/dual-role-of-the-toxoplasma-gondii-clathrin-adaptor-ap1-in-the-sorting-of-rhoptry-and-microneme-proteins-and-in-parasite-division
#2
Kannan Venugopal, Elisabeth Werkmeister, Nicolas Barois, Jean-Michel Saliou, Anais Poncet, Ludovic Huot, Fabien Sindikubwabo, Mohamed Ali Hakimi, Gordon Langsley, Frank Lafont, Sabrina Marion
Toxoplasma gondii possesses a highly polarized secretory system, which efficiently assembles de novo micronemes and rhoptries during parasite replication. These apical secretory organelles release their contents into host cells promoting parasite invasion and survival. Using a CreLox-based inducible knock-out strategy and the ddFKBP over-expression system, we unraveled novel functions of the clathrin adaptor complex TgAP1. First, our data indicate that AP1 in T. gondii likely functions as a conserved heterotetrameric complex composed of the four subunits γ, β, μ1, σ1 and interacts with known regulators of clathrin-mediated vesicular budding such as the unique ENTH-domain containing protein, which we named Epsin-like protein (TgEpsL)...
April 21, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28429960/extracellular-matrix-markers-and-risk-of-myocardial-infarction-the-hunt-study-in-norway
#3
Thor Ueland, Lars E Laugsand, Lars J Vatten, Imre Janszky, Carl Platou, Annika E Michelsen, Jan K Damås, Pål Aukrust, Bjørn O Åsvold
Aims Extracellular matrix remodelling may influence atherosclerotic progression and plaque stability. We hypothesized that evaluation of extracellular matrix markers, with potentially different roles during atherogenesis, could provide information on underlying mechanisms and risk of myocardial infarction (MI) in apparently healthy individuals. Methods We conducted a case-control study nested within the population-based HUNT2 cohort in Norway. A total of 58,761 men and women, free of known cardiovascular disease, were followed for a first MI...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28428450/independent-and-combined-effects-of-serum-albumin-and-c-reactive-protein-on-long-term-outcomes-of-patients-undergoing-percutaneous-coronary-intervention
#4
Hideki Wada, Tomotaka Dohi, Katsumi Miyauchi, Shinichiro Doi, Ryo Naito, Hirokazu Konishi, Shuta Tsuboi, Manabu Ogita, Takatoshi Kasai, Shinya Okazaki, Kikuo Isoda, Satoru Suwa, Hiroyuki Daida
BACKGROUND: Both inflammation and malnutrition have been reported to be closely linked to atherosclerosis, especially in patients with chronic kidney disease (CKD). The combined effects of serum albumin and C-reactive protein (CRP) on clinical outcomes after percutaneous coronary intervention (PCI) were investigated.Methods and Results:A total of 2,164 all-comer patients with coronary artery disease who underwent their first PCI and had data available for preprocedural serum albumin and hs-CRP levels between 2000 and 2011 were studied...
April 19, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28425641/molecular-dynamics-simulations-of-early-steps-in-rna-mediated-conversion-of-prions
#5
Erik J Alred, Michael Nguyen, Maggie Martin, Ulrich Hansmann
The rate-limiting step in prion diseases is the initial transition of a prion protein from its native form into a mis-folded state in which the protein not only forms cell-toxic aggregates but also becomes infectious. Recent experiments implicate polyadenosine RNA as a possible agent for generating the initial seed. In order to understand the mechanism of RNA-mediated mis-folding and aggregation of prions, we dock polyadenosine RNA to mouse and human prion models. Changes in stability and secondary structure of the prions upon binding to polyadenosine RNA are evaluated by comparing molecular dynamics simulations of these complexes with that of the unbound prions...
April 20, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28422975/children-s-weight-changes-according-to-maternal-perception-of-the-child-s-weight-and-health-a-prospective-cohort-of-peruvian-children
#6
Rodrigo M Carrillo-Larco, Antonio Bernabe-Ortiz, J Jaime Miranda, Hong Xue, Youfa Wang
The aim of the study was to estimate the association between maternal perception of their child's health status and (mis)classification of their child's actual weight with future weight change. We present cross-sectional and longitudinal analyses from the Peruvian younger cohort of the Young Lives Study. For cross-sectional analysis, the exposure was maternal perception of child health status (better, same or worse); the outcome was underestimation or overestimation of the child's actual weight. Mothers were asked about their perception of their child's weight (same, lighter or heavier than other children)...
2017: PloS One
https://www.readbyqxmd.com/read/28420657/a-neural-basis-for-password-based-species-recognition-in-an-avian-brood-parasite
#7
Kathleen S Lynch, Annmarie Gaglio, Elizabeth Tyler, Joseph Coculo, Matthew I M Louder, Mark E Hauber
Obligate avian brood parasites are raised by heterospecific hosts and therefore, lack critical early exposure to relatives and other conspecifics. Yet, young brood parasites readily recognize and affiliate with others of their own species upon independence. One solution to this social recognition paradox is the ontogenetic password mechanism utilized by obligate parasitic brown-headed cowbirds (Molothrus ater), whereby conspecific identification is initially mediated through the cowbird chatter, a non-learned vocal cue...
April 18, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28420212/nutritional-status-predicts-10-year-mortality-in-patients-with-end-stage-renal-disease-on-hemodialysis
#8
Shin Sook Kang, Jai Won Chang, Yongsoon Park
Protein-energy wasting (PEW) is associated with mortality in patients with end-stage renal disease (ESRD) on maintenance hemodialysis. The correct diagnosis of PEW is extremely important in order to predict clinical outcomes. However, it is unclear which parameters should be used to diagnose PEW. Therefore, this retrospective observational study investigated the relationship between mortality and nutritional parameters in ESRD patients on maintenance hemodialysis. A total of 144 patients were enrolled. Nutritional parameters, including body mass index, serum albumin, dietary intake, normalized protein catabolic rate (nPCR), and malnutrition inflammation score (MIS), were measured at baseline...
April 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28419312/minimally-invasive-transforaminal-lumbar-interbody-fusion-meta-analysis-of-the-fusion-rates-what-is-the-optimal-graft-material
#9
Avelino Parajón, Marjan Alimi, Rodrigo Navarro-Ramirez, Paul Christos, Jose M Torres-Campa, Yu Moriguchi, Gernot Lang, Roger Härtl
BACKGROUND: Minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) is an increasingly popular procedure with several potential advantages over traditional open TLIF. OBJECTIVE: The current study aimed to compare fusion rates of different graft materials used in MIS-TLIF, via meta-analysis of the published literature. METHODS: A Medline search was performed and a database was created including patient's type of graft, clinical outcome, fusion rate, fusion assessment modality, and duration of follow-up...
April 17, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28417444/a-retinaculum-sparing-surgical-approach-preserves-porcine-stifle-joint-cartilage-in-an-experimental-animal-model-of-cartilage-repair
#10
Marcelo B Bonadio, James M Friedman, Mackenzie L Sennett, Robert L Mauck, George R Dodge, Henning Madry
BACKGROUND: This study compares a traditional parapatellar retinaculum-sacrificing arthrotomy to a retinaculum-sparing arthrotomy in a porcine stifle joint as a cartilage repair model. FINDINGS: Surgical exposure of the femoral trochlea of ten Yucatan pigs stifle joint was performed using either a traditional medial parapatellar approach with retinaculum incision and luxation of the patella (n = 5) or a minimally invasive (MIS) approach which spared the patellar retinaculum (n = 5)...
December 2017: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/28417214/neural-processes-associated-with-vocabulary-and-vowel-length-differences-in-a-dialect-an-erp-study-in-pre-literate-children
#11
Jessica C Bühler, Franziska Waßmann, Daniela Buser, Flutra Zumberi, Urs Maurer
Although familiarity with a language impacts how phonology and semantics are processed at the neural level, little is known how these processes are affected by familiarity with a dialect. By measuring event-related potentials (ERPs) in kindergarten children we investigated neural processing related to familiarity with dialect-specific pronunciation and lexicality of spoken words before literacy acquisition in school. Children speaking one of two German dialects were presented with spoken word-picture pairings, in which congruity (or the lack thereof) was defined by dialect familiarity with pronunciation or vocabulary...
April 17, 2017: Brain Topography
https://www.readbyqxmd.com/read/28416827/-comparison-of-the-effects-of-total-hip-arthroplasty-via-direct-anterior-approach-and-posterolateral-piriformis-sparing-approach
#12
J Xu, W D Zhuang, X W Li, G Y Yu, Y Lin, F Q Luo, Y H Xiao
OBJECTIVE: To compare the clinical effects of direct anterior approach (DAA) and posterolateral piriformis-sparing approach (Mis-PLA) for minimally invasive surgery of total hip arthroplasty. METHODS: The patients who had total hip arthroplasty from March 2015 to February 2016 were randomly divided into 2 groups: DAA group and Mis-PLA group. In the study, 43 patients (45 hips) were performed with total hip replacement via the direct anterior approach (DAA group)...
April 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28416088/a-novel-mis-technique-for-posterior-cruciate-ligament-avulsion-fractures
#13
Ashok S Gavaskar, Bhupesh Karthik, Hitesh Gopalan, Parthasarathy Srinivasan, Naveen C Tummala
OBJECTIVE: Open surgical approaches to treat tibial avulsion fractures of the posterior cruciate ligament (PCL) often use large incisions involving extensive muscle dissection and retraction. The objective of this study was to describe a new mini-invasive approach targeting the fractured zone, to minimize surgical dissection and improve recovery and rehabilitation. METHODS: The new approach was used in 15 males and seven females with isolated PCL avulsions. The length of the surgical incision, surgical time, need for conversion to open technique, visual analog scores (VAS) and duration of hospital stay were studied to assess the efficacy, learning curve and advantages of the new technique...
April 13, 2017: Knee
https://www.readbyqxmd.com/read/28415765/stable-aneuploid-tumors-cells-are-more-sensitive-to-ttk-inhibition-than-chromosomally-unstable-cell-lines
#14
Marion A A Libouban, Jeroen A D M de Roos, Joost C M Uitdehaag, Nicole Willemsen-Seegers, Sara Mainardi, Jelle Dylus, Jos de Man, Bastiaan Tops, Jules P P Meijerink, Zuzana Storchová, Rogier C Buijsman, René H Medema, Guido J R Zaman
Inhibition of the spindle assembly checkpoint kinase TTK causes chromosome mis-segregation and tumor cell death. However, high levels of TTK correlate with chromosomal instability (CIN), which can lead to aneuploidy. We show that treatment of tumor cells with the selective small molecule TTK inhibitor NTRC 0066-0 overrides the mitotic checkpoint, irrespective of cell line sensitivity. In stable aneuploid cells NTRC 0066-0 induced acute CIN, whereas in cells with high levels of pre-existing CIN there was only a small additional fraction of cells mis-segregating their chromosomes...
March 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28415055/-risk-factors-for-predicting-the-need-for-additional-surgery-for-symptomatic-adjacent-segment-disease-after-minimally-invasive-surgery-transforaminal-lumbar-interbody-fusion
#15
Kenji Fukaya, Mitsuhiro Hasegawa, Mitsuru Shirato, Takashi Teshima
PURPOSE: To determine the incidence of and risk factors for symptomatic adjacent segment disease(SASD)requiring additional surgery in patients previously treated with minimally invasive surgery-transforaminal lumbar interbody fusion(MIS-TLIF)for degenerative lumbar disease. MATERIALS AND METHODS: A series of 467 consecutive patients who had undergone MIS-TLIF of one or two segments to treat degenerative lumbar disease was identified. The mean age of the patients at the time of the index operation was 67...
April 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28412563/how-are-patients-influenced-when-counselled-for-minimally-invasive-lumbar-spine-surgeries-a-stepwise-model-assessing-pivotal-information-for-decision-making
#16
Hwee Weng Dennis Hey, Nishant Kumar, Alex Quok An Teo, Kimberly-Anne Tan, Ka-Po Gabriel Liu, Hee-Kit Wong
BACKGROUND CONTEXT: While minimally invasive surgery (MIS) transforaminal lumbar interbody fusion (TLIF) has many evidence-based short-term benefits over open TLIF, both procedures have similar long-term outcomes. Patients' preference for MIS over open TLIF may be confounded by a lack of understanding of what each approach entails. PURPOSE: To identify the various factors influencing patients' choice between MIS and open TLIF. STUDY DESIGN/SETTING: Cross-sectional study conducted at a tertiary healthcare institution PATIENT SAMPLE: Patients, for whom TLIF procedures were indicated, were recruited over a 3-month period from specialist outpatient clinics OUTCOME MEASURES: Patients' choice of surgical approach (MIS or Open) METHODS: All patients were subjected to a stepwise interviewing process, and were asked to select between open and MIS approaches at each step...
April 12, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28412545/dna-topoisomerase-1-prevents-r-loop-accumulation-to-modulate-auxin-regulated-root-development-in-rice
#17
Sarfraz Shafiq, Chunli Chen, Jing Yang, Lingling Cheng, Fei Ma, Emilie Widemann, Qianwen Sun
R-loop structures (RNA:DNA hybrids) have important functions in many biological processes, including transcriptional regulation and genome instability among diverse organisms. DNA Topoisomerase 1 (TOP1), an essential manipulator of DNA topology during RNA transcription and DNA replication processes, can prevent R-loop accumulation by removing the positive and negative DNA supercoiling that is made by RNA polymerases during transcription. TOP1 is required for plant development, but little is known about its function in preventing co-transcriptional R-loops in different plant biological processes...
April 12, 2017: Molecular Plant
https://www.readbyqxmd.com/read/28407213/analysis-of-multiple-diverse-phenotypes-via-semiparametric-canonical-correlation-analysis
#18
Denis Agniel, Tianxi Cai
Studying multiple outcomes simultaneously allows researchers to begin to identify underlying factors that affect all of a set of diseases (i.e., shared etiology) and what may give rise to differences in disorders between patients (i.e., disease subtypes). In this work, our goal is to build risk scores that are predictive of multiple phenotypes simultaneously and identify subpopulations at high risk of multiple phenotypes. Such analyses could yield insight into etiology or point to treatment and prevention strategies...
April 13, 2017: Biometrics
https://www.readbyqxmd.com/read/28406346/a-novel-laparoscopic-grasper-with-two-parallel-jaws-capable-of-extracting-the-mechanical-behaviour-of-soft-tissues
#19
Dariush Nazarynasab, Farzam Farahmand, Alireza Mirbagheri, Elnaz Afshari
Data related to force-deformation behaviour of soft tissue plays an important role in medical/surgical applications such as realistically modelling mechanical behaviour of soft tissue as well as minimally invasive surgery (MIS) and medical diagnosis. While the mechanical behaviour of soft tissue is very complex due to its different constitutive components, some issues increase its complexity like behavioural changes between the live and dead tissues. Indeed, an adequate quantitative description of mechanical behaviour of soft tissues requires high quality in vivo experimental data to be obtained and analysed...
April 13, 2017: Journal of Medical Engineering & Technology
https://www.readbyqxmd.com/read/28404657/predicting-and-reducing-driving-mishaps-among-drivers-with-type-1-diabetes
#20
Daniel J Cox, Linda A Gonder-Frederick, Harsimran Singh, Karen S Ingersoll, Tom Banton, Jesse H Grabman, Karen Schmidt, William Clarke
OBJECTIVE: Two aims of this study were to develop and validate 1) a metric to identify drivers with type 1 diabetes at high risk of future driving mishaps and 2) an online intervention to reduce mishaps among high-risk drivers. RESEARCH DESIGN AND METHODS: To achieve aim A, in study 1, 371 drivers with type 1 diabetes from three U.S. regions completed a series of established questionnaires about diabetes and driving. They recorded their driving mishaps over the next 12 months...
April 12, 2017: Diabetes Care
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