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https://www.readbyqxmd.com/read/29452348/non-invasive-screening-for-coronary-artery-disease-in-asymptomatic-diabetic-patients-a-systematic-review-and-meta-analysis-of-randomised-controlled-trials
#1
Olivier F Clerc, Tobias A Fuchs, Julia Stehli, Dominik C Benz, Christoph Gräni, Michael Messerli, Andreas A Giannopoulos, Ronny R Buechel, Thomas F Lüscher, Aju P Pazhenkottil, Philipp A Kaufmann, Oliver Gaemperli
It is unclear whether non-invasive screening of asymptomatic diabetic patients for coronary artery disease (CAD) may improve cardiac outcomes. Thus, we performed a systematic literature review and meta-analysis of randomised controlled trials (RCT's) on this topic. We searched appropriate RCT's in five online databases (PubMed/MEDLINE, Cochrane Library, Embase, Scopus, and Web of Science) from January 2000 to November 2017 and in 41 recent reviews. Two investigators independently extracted and assessed study data using standardised forms...
February 14, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29451892/assessing-site-formation-and-assemblage-integrity-through-stone-tool-refitting-at-gruta-da-oliveira-almonda-karst-system-torres-novas-portugal-a-middle-paleolithic-case-study
#2
Marianne Deschamps, João Zilhão
We use stone tool refitting to assess palimpsest formation and stratigraphic integrity in the basal units of the Gruta da Oliveira archeo-stratigraphic sequence, layers 15-27, which TL and U-series dating places in late Marine Isotope Stage (MIS) 5 or early MIS 4. As in most karst contexts, the formation of this succession involved multiple and complex phenomena, including subsidence, bioturbation, carnivore activity and runoff as agents of potential post-depositional disturbance. During phases of stabilization, such as represented by layers 15, 21 and 22, the excavated area was inhabited and refits corroborate that post-depositional displacement is negligible...
2018: PloS One
https://www.readbyqxmd.com/read/29444690/efficacy-of-n-n-bis-2-mercaptoethyl-isophthalamide-on-mercury-intoxication-a-randomized-controlled-trial
#3
Paul Schutzmeier, Augusto Focil Baquerizo, Wilson Castillo-Tandazo, Nicholas Focil, Stephan Bose-O'Reilly
BACKGROUND: Chronic mercury intoxication is a severe health issue and occurs especially in gold mining communities. Common chelators used for improving mercury elimination are not everywhere available and challenged by poor cell wall penetration. This study is part of a feasibility trial and the aim was to gather first information about the efficacy of the newly developed chelator N,N'bis-(2-mercaptoethyl) isophthalamide (NBMI) on chronic mercury intoxication. METHODS: In this three-armed, placebo-controlled randomized trial, 36 miners with mercury urine levels exceeding 15 μg/l were administered 100 mg NBMI, 300 mg NBMI or placebo for 14 days...
February 14, 2018: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29436251/improvement-of-metabolic-control-and-diabetes-management-in-insulin-treated-patients-results-in-substantial-cost-savings-for-the-german-health-system
#4
Katharina Fritzen, Bettina Gutschek, Benedikte Coucke, Katerina Zakrzewska, Michael Hummel, Oliver Schnell
BACKGROUND: Self-monitoring of blood glucose (SMBG) using the ColourSure™ Technology to visualize target range showed improvement of metabolic control and overall diabetes self-management in insulin-treated patients. This economic analysis aimed to identify cost savings for the German health system resulting from an HbA1c reduction due to the utilization of user-friendly glucose meters. METHODS: Patient data from a recently published observational study on SMBG were used for risk evaluations using the UKPDS risk engine...
February 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29435653/epidemiological-trends-in-spine-surgery-over-10%C3%A2-years-in-a-multicenter-database
#5
Kazuyoshi Kobayashi, Kei Ando, Yoshihiro Nishida, Naoki Ishiguro, Shiro Imagama
PURPOSE: There are few epidemiological studies of spinal surgery in Asia and none in Japan. The goal of this study was to review spine surgeries performed in our group between 2004 and 2015 in a cross-sectional study, with a focus on the effects of the superaging society on the characteristics and trends of spinal surgeries. METHODS: A retrospective review was performed for all 45,831 spinal surgeries conducted between 2004 and 2015 and recorded in our prospective multicenter database...
February 12, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29434616/pollen-from-the-deep-sea-a-breakthrough-in-the-mystery-of-the-ice-ages
#6
REVIEW
María F Sánchez Goñi, Stéphanie Desprat, William J Fletcher, César Morales-Molino, Filipa Naughton, Dulce Oliveira, Dunia H Urrego, Coralie Zorzi
Pollen from deep-sea sedimentary sequences provides an integrated regional reconstruction of vegetation and climate (temperature, precipitation, and seasonality) on the adjacent continent. More importantly, the direct correlation of pollen, marine and ice indicators allows comparison of the atmospheric climatic changes that have affected the continent with the response of the Earth's other reservoirs, i.e., the oceans and cryosphere, without any chronological uncertainty. The study of long continuous pollen records from the European margin has revealed a changing and complex interplay between European climate, North Atlantic sea surface temperatures (SSTs), ice growth and decay, and high- and low-latitude forcing at orbital and millennial timescales...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29433885/can-flow-cytometry-reinvent-the-sentinel-lymph-node-concept-in-gastric-cancer-patients
#7
Tomaz Jagric, Katarina Mis, Maksimilijan Gorenjak, Ales Goropevsek, Rajko Kavalar, Tomaz Mars
BACKGROUND: The focused sentinel lymph node (SLN) concept we proposed previously relied on real time-quantitative polymerase chain reaction (RT-qPCR) to detect tumor cells, which is too elaborate for intraoperative use. Therefore, we evaluated flow cytometry for intraoperative detection of tumor cells in SLNs. METHODS: Sixty-five consecutive gastric cancer patients were included. SLN analysis was carried out for a single SLN from each patient, using the molecular methods of RT-qPCR (first 30 patients) and flow cytometry (final 35 patients)...
March 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29432289/surgeon-hospital-and-geographic-variation-in-minimally-invasive-colectomy
#8
Christopher T Aquina, Adan Z Becerra, Carla F Justiniano, Zhaomin Xu, Francis P Boscoe, Maria J Schymura, Katia Noyes, John R T Monson, Larissa K Temple, Fergal J Fleming
OBJECTIVE: To identify sources of variation in the use of minimally invasive surgery (MIS) for colectomy. BACKGROUND: MIS is associated with decreased analgesic use, shorter length of stay, and faster postoperative recovery. This study identified factors explaining variation in MIS use for colectomy. METHODS: The Statewide Planning and Research Cooperative System was queried for scheduled admissions in which a colectomy was performed for neoplastic, diverticular, or inflammatory bowel disease between 2008 and 2015...
February 9, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29431512/heparanase-is-a-critical-regulator-of-mitotic-spindles-required-for-maintaining-chromosome-stability
#9
Shuo Yang, Yong Liao, Qi Zhao, Yuqin Xie, Ai Zheng, Huajing Wan
The mitotic spindle, assembled by microtubule organization center (MTOC), is a critical structure required for proper chromosome segregation during mitosis. Studies demonstrated that defects of mitotic spindle assembling would result in chromosome instability, associating with oncogenesis. In this study, we identified that heparanase (HPSE) was localized on MTOC in mitotic cells. Induced expression of HPSE in human airway epithelial cells promoted mitotic spindle formation, and silencing of HPSE expression disrupted the mitotic spindle formation, resulting in chromosome instability, including chromosome mis-segregation and increased micronuclei formation...
February 12, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29430766/normative-data-for-the-montreal-cognitive-assessment-moca-and-the-memory-index-score-moca-mis-in-brazil-adjusting-the-nonlinear-effects-of-education-with-fractional-polynomials
#10
Daniel Apolinario, Marília Funchal Dos Santos, Eduardo Sassaki, Fernanda Pegoraro, Anna Vitoria Alves Pedrini, Bruna Cestari, Ana Helena Amaral, Mayra Mitt, Marina Bellatti Müller, Claudia Kimie Suemoto, Ivan Aprahamian
No abstract text is available yet for this article.
February 12, 2018: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29430064/survival-analysis-with-functions-of-mismeasured-covariate-histories-the-case-of-chronic-air-pollution-exposure-in-relation-to-mortality-in-the-nurses-health-study
#11
Xiaomei Liao, Xin Zhou, Molin Wang, Jaime E Hart, Francine Laden, Donna Spiegelman
Environmental epidemiologists are often interested in estimating the effect of functions of time-varying exposure histories, such as the 12-month moving average, in relation to chronic disease incidence or mortality. The individual exposure measurements that comprise such an exposure history are usually mis-measured, at least moderately, and, often, more substantially. To obtain unbiased estimates of Cox model hazard ratios for these complex mis-measured exposure functions, an extended risk set regression calibration method for Cox models is developed and applied to a study of long-term exposure to the fine particulate matter (PM2...
February 2018: Journal of the Royal Statistical Society. Series C, Applied Statistics
https://www.readbyqxmd.com/read/29429924/the-tia1-rna-binding-protein-family-regulates-eif2ak2-mediated-stress-response-and-cell-cycle-progression
#12
Cindy Meyer, Aitor Garzia, Michael Mazzola, Stefanie Gerstberger, Henrik Molina, Thomas Tuschl
TIA1 and TIAL1 encode a family of U-rich element mRNA-binding proteins ubiquitously expressed and conserved in metazoans. Using PAR-CLIP, we determined that both proteins bind target sites with identical specificity in 3' UTRs and introns proximal to 5' as well as 3' splice sites. Double knockout (DKO) of TIA1 and TIAL1 increased target mRNA abundance proportional to the number of binding sites and also caused accumulation of aberrantly spliced mRNAs, most of which are subject to nonsense-mediated decay. Loss of PRKRA by mis-splicing triggered the activation of the double-stranded RNA (dsRNA)-activated protein kinase EIF2AK2/PKR and stress granule formation...
February 15, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29425039/e22g-pathogenic-mutation-of-%C3%AE-amyloid-a%C3%AE-enhances-mis-folding-of-a%C3%AE-40-by-unexpected-prion-like-cross-talk-be-tween-a%C3%AE-42-and-a%C3%AE-40
#13
Brian K Yoo, Yiling Xiao, Dan McElheny, Yoshitaka Ishii
Cross-seeding of misfolded amyloid proteins is believed to induce cross-species infection of prion diseases. In sporadic Alzheimer's disease (AD), misfolding of 42-residue β-amyloid (Aβ) is widely considered to trigger amyloid plaque deposition. Despite increasing evidence that misfolded Aβ mimics prions, interactions of misfolded 42-residue Aβ42 with more abundant 40-residue Aβ40 in AD are elusive. This study presents in-vitro evidence that a heterozygous E22G pathogenic ("Arctic") mutation of Aβ40 can enhance misfolding of Aβ via cross-seeding from wild-type (WT) Aβ42 fibril...
February 9, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29423651/genetic-and-functional-analysis-of-shroom1-4-in-a-chinese-neural-tube-defect-cohort
#14
Zhongzhong Chen, Lele Kuang, Richard H Finnell, Hongyan Wang
Neural tube defects (NTDs), which include spina bifida and anencephaly, are the second most common form of human structural congenital malformations. While it is well established that SHROOM3 plays a pivotal role in the complex morphogenetic processes involved in neural tube closure (NTC), the underlying genetic contributions of SHROOM gene family members in the etiology of human NTDs remain poorly understood. Herein, we systematically investigated the mutation patterns of SHROOM1-4 in a Chinese population composed of 343 NTD cases and 206 controls, using targeted next-generation sequencing...
February 8, 2018: Human Genetics
https://www.readbyqxmd.com/read/29423553/force-based-learning-curve-tracking-in-fundamental-laparoscopic-skills-training
#15
Sem F Hardon, Tim Horeman, H Jaap Bonjer, W J H Jeroen Meijerink
BACKGROUND: Within minimally invasive surgery (MIS), structural implementation of courses and structured assessment of skills are challenged by availability of trainers, time, and money. We aimed to establish and validate an objective measurement tool for preclinical skills acquisition in a basic laparoscopic at-home training program. METHODS: A mobile laparoscopic simulator was equipped with a state-of-the-art force, motion, and time tracking system (ForceSense, MediShield B...
February 8, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29422252/achieving-high-quality-standards-in-laparoscopic-colon-resection-for-cancer-a-delphi-consensus-based-position-paper
#16
Laura Lorenzon, Alberto Biondi, Thomas Carus, Adam Dziki, Eloy Espin, Nuno Figueiredo, Marcos Gomez Ruiz, Tamas Mersich, Isacco Montroni, Pieter J Tanis, Stefan Rolf Benz, Paolo Pietro Bianchi, Matthias Biebl, Ivo Broeders, Raffaele De Luca, Paolo Delrio, Mathieu D'Hondt, Alois Fürst, Jan Grosek, Jose Flavio Guimaraes Videira, Friedrich Herbst, David Jayne, György Lázár, Danilo Miskovic, Andrea Muratore, Ole Helmer Sjo, Tom Scheinin, Ales Tomazic, Andreas Türler, Cornelius Van de Velde, Steven D Wexner, Christoph Wullstein, Wojciech Zegarski, Domenico D'Ugo
AIM: To investigate the rate of laparoscopic colectomies for colon cancer using registries and population-based studies. To provide a position paper on mini-invasive (MIS) colon cancer surgery based on the opinion of experts leader in this field. METHODS: A systematic review of the literature was conducted using PRISMA guidelines for the rate of laparoscopy in colon cancer. Moreover, Delphi methodology was used to reach consensus among 35 international experts in four study rounds...
February 5, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29422025/peak-ck-mb-has-a-strong-association-with-chronic-scar-size-and-wall-motion-abnormalities-after-revascularized-non-transmural-myocardial-infarction-a-prospective-cmr-study
#17
Pauli Pöyhönen, Minna Kylmälä, Paula Vesterinen, Sari Kivistö, Miia Holmström, Kirsi Lauerma, Heikki Väänänen, Lauri Toivonen, Helena Hänninen
BACKGROUND: Large myocardial infarction (MI) is associated with adverse left ventricular (LV) remodeling (LVR). We studied the nature of LVR, with specific attention to non-transmural MIs, and the association of peak CK-MB with recovery and chronic phase scar size and LVR. METHODS: Altogether 41 patients underwent prospectively repeated cardiovascular magnetic resonance at a median of 22 (interquartile range 9-29) days and 10 (8-16) months after the first revascularized MI...
February 8, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29421012/clinical-features-and-outcomes-of-patients-with-type-2-myocardial-infarction-insights-from-the-thrombin-receptor-antagonist-for-clinical-event-reduction-in-acute-coronary-syndrome-tracer-trial
#18
Patrícia O Guimarães, Sergio Leonardi, Zhen Huang, Lars Wallentin, Frans Van de Werf, Philip E Aylward, Claes Held, Robert A Harrington, David J Moliterno, Paul W Armstrong, Harvey D White, Karen P Alexander, Renato D Lopes, Kenneth W Mahaffey, Pierluigi Tricoci
BACKGROUND: Type 2 myocardial infarction (MI) is characterized by an imbalance between myocardial blood supply and demand, leading to myocardial ischemia without coronary plaque rupture, but its diagnosis is challenging. METHODS: In the TRACER trial, patients with non-ST-segment elevation acute coronary syndromes were included. We aimed to describe provoking factors, cardiac biomarker profiles, treatment patterns, and clinical outcomes of patients with type 2 MIs...
February 2018: American Heart Journal
https://www.readbyqxmd.com/read/29419873/-genetic-analysis-of-a-case-with-atypical-neonatal-cri-du-chat-syndrome
#19
Wenfeng He, He Chen, Haiyan Mu, Jie Li
OBJECTIVE To analyze the clinical features and genetic mutations in a neonate with atypical Cri-du-chat syndrome, whom only featured with weak cry but had no dysmorphic facial features and congenital heart disease. METHODS G-banding karyotyping was performed on the child and her parents. The result was validated by fluorescence in situ hybridization (FISH). Chromosome microarray (CMA) was used to further delineate the mutation. RESULTS G-banding analysis suggested that the child had a karyotype of 46,XX,del(5)(p14p15), while both of his parents had a normal karyotype...
February 10, 2018: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/29419568/recent-abacavir-use-increases-risk-for-types-1-and-2-myocardial-infarctions-among-adults-with-hiv
#20
Richard A Elion, Keri N Althoff, Jinbing Zhang, Richard D Moore, Stephen J Gange, Mari M Kitahata, Heidi M Crane, Daniel R Drozd, James H Stein, Marina B Klein, Joseph J Eron, Michael J Silverberg, William C Mathews, Amy C Justice, Timothy R Sterling, Charles S Rabkin, Angel M Mayor, Daniel B Klein, Michael A Horberg, Ronald J Bosch, Oghenowede Eyawo, Frank J Palella
BACKGROUND: There is persistent confusion as to whether abacavir (ABC) increases the risk for myocardial infarction (MI), and whether such risk differs by Type 1 (T1MI) or 2 (T2MI) MI in adults with HIV. METHODS: Incident MIs in NA-ACCORD participants were identified from 2001 to 2013. Discrete time marginal structural models addressed channeling biases and time-dependent confounding to estimate crude (HR) and adjusted hazard ratios (aHR) and 95% confidence intervals; analyses were performed for T1MI and T2MI separately...
February 6, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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