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https://www.readbyqxmd.com/read/29049508/outcomes-in-women-and-minorities-compared-with-white-men-1-year-after-everolimus-eluting-stent-implantation-insights-and-results-from-the-platinum-diversity-and-promus-element-plus-post-approval-study-pooled-analysis
#1
Wayne Batchelor, David E Kandzari, Scott Davis, Luis Tami, John C Wang, Islam Othman, Osvaldo S Gigliotti, Amir Haghighat, Sarabjeet Singh, Mario Lopez, Gregory Giugliano, Phillip A Horwitz, Jaya Chandrasekhar, Paul Underwood, Craig A Thompson, Roxana Mehran
Importance: There exist limited outcomes data for women and minorities after contemporary percutaneous coronary intervention (PCI). Objective: To examine 1-year outcomes in women and minorities vs white men after PCI with everolimus-eluting stents. Design, Settings, and Participants: The PLATINUM Diversity study was a single-arm study enrolling women and minorities. Patient-level pooling with the PROMUS Element Plus Post-Approval Study was prespecified...
October 18, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/29047185/pluripotent-stem-cell-derived-haematopoietic-progenitors-are-unable-to-downregulate-key-emt-associated-mirnas
#2
Ellie Meader, Tomas Barta, Dario Melguzo-Sanchis, Katarzyna Tilgner, David Montaner, Ashraf A El-Harouni, Lyle Armstrong, Majlinda Lako
Haematopoietic stem cells derived from pluripotent stem cells could be used as an alternative to bone marrow transplants. Deriving these has been a long-term goal for researchers. However, the success of these efforts has been limited, with the cells produced able to engraft in the bone marrow of recipient animals only in very low numbers. There is evidence that defects in the migratory and homing capacity of the cells are due to mis-regulation of miRNA expression, and are responsible for their failure to engraft...
October 19, 2017: Stem Cells
https://www.readbyqxmd.com/read/29046437/modulation-of-global-transcriptional-regulatory-networks-as-a-strategy-for-increasing-kanamycin-resistance-of-the-translational-elongation-factor-g-mutants-in-escherichia-coli
#3
Aalap Mogre, Reshma T V, Aswin Sai Narain Seshasayee
Evolve and resequence experiments have provided us a tool to understand bacterial adaptation to antibiotics. In our previous work, we had used short term evolution to isolate mutants resistant to the ribosome targeting antibiotic kanamycin, and reported that Escherichia coli develops low cost resistance to kanamycin via  different point mutations in the translation Elongation Factor-G (EF-G). Furthermore, we had shown that the resistance of EF-G mutants could be increased by second site mutations in the genes rpoD / cpxA / topA / cyaA Mutations in three of these genes had been discovered in earlier screens for aminoglycoside resistance...
October 18, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29045974/-echocardiographic-diagnosis-of-infracardiac-total-anomalous-pulmonary-venous-connection
#4
S T Ren, Y Wang, J H Zhou, J Long, C H Wang, D B Li, Y Z Huang
OBJECTIVE: To investigate the clinical usefulness of echocardiography in the diagnosis of infracardiac total anomalous pulmonary venous connection (ITAPVC) in neonates and infants. METHODS: Retrospective analysis on 8 patients with ITAPVC was performed using echocardiography between April 2006 and December 2016. There were 4 boys and 4 girls with a mean age of 79.8 days (ranging from 15 to 195 days). A combined scanning via parasternal, subcostal and apical acoustic windows had been employed to diagnose ITAPVC and to trace the course and site of the anomalous pulmonary venous drainage, and to confirm the direction of the inter-atrial shunt and enlargement of right atrium and right ventricle...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29041602/virtual-ellipsometry-on-layered-micro-facet-surfaces
#5
Chi Wang, Alexander Wilkie, Petr Harcuba, Lukas Novosad
Microfacet-based BRDF models are a common tool to describe light scattering from glossy surfaces. Apart from their wide-ranging applications in optics, such models also play a significant role in computer graphics for photorealistic rendering purposes. In this paper, we mainly investigate the computer graphics aspect of this technology, and present a polarisation-aware brute force simulation of light interaction with both single and multiple layered micro-facet surfaces. Such surface models are commonly used in computer graphics, but the resulting BRDF is ultimately often only approximated...
September 18, 2017: Optics Express
https://www.readbyqxmd.com/read/29041239/subcutaneous-veins-depth-measurement-using-diffuse-reflectance-images
#6
C M Goh, R Subramaniam, N M Saad, S A Ali, F Meriaudeau
Intravenous (IV) procedures are often difficult due to the poor visualization of subcutaneous veins. Because existing vein locators lack the ability to assess depth, and also because mis-punctures and poor vascular access remain problematic, we propose an imaging system that employs diffuse reflectance images at three isosbestic wavelengths to measure both the depth and thickness of subcutaneous veins. This paper describes the proposed system as well as proof-of-principle experimental demonstrations. We initially introduce the working principle and structure of the system...
October 16, 2017: Optics Express
https://www.readbyqxmd.com/read/29037818/snrnp-proteins-in-health-and-disease
#7
REVIEW
Michaela Krausová, David Staněk
Split gene architecture of most human genes requires removal of intervening sequences by mRNA splicing that occurs on large multiprotein complexes called spliceosomes. Mutations compromising several spliceosomal components have been recorded in degenerative syndromes and haematological neoplasia, thereby highlighting the importance of accurate splicing execution in homeostasis of assorted adult tissues. Moreover, insufficient splicing underlies defective development of craniofacial skeleton and upper extremities...
October 13, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29034944/power-of-protein-trna-functional-assembly-against-aberrant-aggregation
#8
Charles Bou-Nader, Ludovic Pecqueur, David Cornu, Murielle Lombard, Manuela Dezi, Magali Nicaise, Christophe Velours, Marc Fontecave, Djemel Hamdane
Understanding the mechanisms of protein oligomerization and aggregation is a major concern for biotechnology and medical purposes. However, significant challenges remain in determining the mechanism of formation of these superstructures and the environmental factors that can precisely modulate them. Notably the role that a functional ligand plays in the process of protein aggregation is largely unexplored. We herein address these issues with an original flavin-dependent RNA methyltransferase (TrmFO) used as a protein model since this protein employs a complex set of cofactors and ligands for catalysis...
October 16, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29033025/the-clinical-utility-of-immunoglobulin-g4-in-the-evaluation-of-autoimmune-pancreatitis-and-pancreatic-adenocarcinoma
#9
Linda M Pak, Mark A Schattner, Vinod Balachandran, Michael I D'Angelica, Ronald P DeMatteo, T Peter Kingham, William R Jarnagin, Peter J Allen
BACKGROUND: Elevation in the serum immunoglobulin-G4 (IgG4) level has been used as a diagnostic marker to distinguish autoimmune pancreatitis (AIP) from pancreatic ductal adenocarcinoma (PDAC), but its true utility is ill-defined. This study evaluates the clinical utility of IgG4 in differentiating AIP from PDAC. METHODS: All patients evaluated in the hepatopancreaticobiliary surgery clinics with measured serum IgG4 were included. Patients were divided into normal IgG4 (<135 mg/dL) and elevated IgG4 (≥135 mg/dL) groups...
October 9, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29032581/utilization-and-quality-outcomes-of-ct1a-ct1b-and-ct2a-partial-nephrectomy-analysis-of-the-national-cancer-database
#10
Katherine Fero, Zachary A Hamilton, Ahmet Bindayi, James D Murphy, Ithaar H Derweesh
OBJECTIVE: To describe utilization and compare quality outcomes of partial nephrectomy (PN) for cT1a, cT1b and cT2a renal mass using a large national database. METHODS: Retrospective analysis of patients from the US National Cancer Database who underwent PN for cT1a/cT1b/T2a renal cell carcinoma between 2004-2013. We examined utilization of PN over time and quality indicators [positive surgical margin (PSM) and 30-day postoperative readmission rates (30Day-Readmit)]...
October 15, 2017: BJU International
https://www.readbyqxmd.com/read/29032253/laparoscopic-dissection-of-extensive-secondary-disseminated-peritoneal-leiomyomatosis-dpl
#11
Karicha Mairaing, Kuan-Gen Huang
STUDY OBJECTIVE: To demonstrate a minimal invasive surgical (MIS) technique for curative excision of extensive secondary disseminated peritoneal leiomyomatosis (DPL). SETTING: In MIS, the myoma has to be divided into small fragments for piecemeal retrieval through a small incision [1], a widely used technique is morcellation (confined or unconfined) [2]. Disseminated peritoneal leiomyomatosis (DPL) is a rare sequel following laparoscopic morcellation. Since this entity is rarely reported, this video demonstrates laparoscopic technique for safe removal of DPL post laparoscopic myomectomy and morcellation...
October 12, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29029684/validation-of-the-three-web-quality-dimensions-of-a-minimally-invasive-surgery-e-learning-platform
#12
Juan Francisco Ortega-Morán, J Blas Pagador, Luisa Fernanda Sánchez-Peralta, Patricia Sánchez-González, José Noguera, Daniel Burgos, Enrique J Gómez, Francisco M Sánchez-Margallo
INTRODUCTION: E-learning web environments, including the new TELMA platform, are increasingly being used to provide cognitive training in minimally invasive surgery (MIS) to surgeons. A complete validation of this MIS e-learning platform has been performed to determine whether it complies with the three web quality dimensions: usability, content and functionality. METHODS: 21 Surgeons participated in the validation trials. They performed a set of tasks in the TELMA platform, where an e-MIS validity approach was followed...
November 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29029343/an-evaluation-of-different-partitioning-strategies-for-bayesian-estimation-of-species-divergence-times
#13
Konstantinos Angelis, Sandra Álvarez-Carretero, Mario Dos Reis, Ziheng Yang
The explosive growth of molecular sequence data has made it possible to estimate species divergence times under relaxed-clock models using genome-scale data sets with many gene loci. In order to improve both model realism and to best extract information about relative divergence times in the sequence data, it is important to account for the heterogeneity in the evolutionary process across genes or genomic regions. Partitioning is a commonly used approach to achieve those goals. We group sites that have similar evolutionary characteristics into the same partition and those with different characteristics into different partitions, and then use different models or different values of model parameters for different partitions to account for the among-partition heterogeneity...
July 4, 2017: Systematic Biology
https://www.readbyqxmd.com/read/29029073/clinical-genetics-and-outcome-of-left-ventricular-non-compaction-cardiomyopathy
#14
Farbod Sedaghat-Hamedani, Jan Haas, Feng Zhu, Christian Geier, Elham Kayvanpour, Martin Liss, Alan Lai, Karen Frese, Regina Pribe-Wolferts, Ali Amr, Daniel Tian Li, Omid Shirvani Samani, Avisha Carstensen, Diana Martins Bordalo, Marion Müller, Christine Fischer, Jing Shao, Jing Wang, Ming Nie, Li Yuan, Sabine Haßfeld, Christine Schwartz, Min Zhou, Zihua Zhou, Yanwen Shu, Min Wang, Kai Huang, Qiutang Zeng, Longxian Cheng, Tobias Fehlmann, Philipp Ehlermann, Andreas Keller, Christoph Dieterich, Katrin Streckfuß-Bömeke, Yuhua Liao, Michael Gotthardt, Hugo A Katus, Benjamin Meder
Aims: In this study, we aimed to clinically and genetically characterize LVNC patients and investigate the prevalence of variants in known and novel LVNC disease genes. Introduction: Left ventricular non-compaction cardiomyopathy (LVNC) is an increasingly recognized cause of heart failure, arrhythmia, thromboembolism, and sudden cardiac death. We sought here to dissect its genetic causes, phenotypic presentation and outcome. Methods and results: In our registry with follow-up of in the median 61 months, we analysed 95 LVNC patients (68 unrelated index patients and 27 affected relatives; definite familial LVNC = 23...
October 6, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29028801/docrl-maintains-immune-cell-quiescence-by-regulating-endosomal-traffic
#15
Steven J Del Signore, Sarah A Biber, Katherine S Lehmann, Stephanie R Heimler, Benjamin H Rosenfeld, Tania L Eskin, Sean T Sweeney, Avital A Rodal
Lowe Syndrome is a developmental disorder characterized by eye, kidney, and neurological pathologies, and is caused by mutations in the phosphatidylinositol-5-phosphatase OCRL. OCRL plays diverse roles in endocytic and endolysosomal trafficking, cytokinesis, and ciliogenesis, but it is unclear which of these cellular functions underlie specific patient symptoms. Here, we show that mutation of Drosophila OCRL causes cell-autonomous activation of hemocytes, which are macrophage-like cells of the innate immune system...
October 13, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29028664/abacavir-use-and-risk-of-recurrent-myocardial-infarction-the-d-a-d-study
#16
Caroline A Sabin, Lene Ryom, Antonella d'Arminio Monforte, Camilla I Hatleberg, Christian Pradier, Wafaa El-Sadr, Ole Kirk, Rainer Weber, Andrew N Phillips, Amanda Mocroft, Fabrice Bonnet, Matthew Law, Stephane de Wit, Peter Reiss, Jens D Lundgren
OBJECTIVE: To investigate the association between abacavir (ABC) use and recurrent myocardial infarction (MI) among HIV-positive people with a prior MI. DESIGN: International multi-cohort collaboration with follow-up from 1999-2016. METHODS: The rate of recurrent MI was described among D:A:D participants who experienced an index MI whilst in the study, and who remained under follow-up beyond 28 days after this MI. Follow-up was considered to the date of next MI, death, 01/Feb/2016 or 6 months after last clinic visit...
October 12, 2017: AIDS
https://www.readbyqxmd.com/read/29027837/malpractice-in-paediatric-minimally-invasive-surgery-a-current-concept-results-of-an-international-survey
#17
Ciro Esposito, Maria Escolino, Marcela Bailez, Steve Rothenberg, Mark Davenport, Amulya Saxena, Anthony Caldamone, Philipp Szavay, Paul Philippe, Holger Till, Philippe Montupet, George W Holcomb Rd
This study aimed to assess malpractice in paediatric minimally invasive surgery (MIS), and attitudes, prevention strategies and mechanisms to support surgeons while they are under investigation. An observational, multicentric, questionnaire-based study was conducted. The survey questionnaire was sent via mail, and it comprised four sections. Twenty-four paediatric surgeons (average age 54.6 years), from 13 different countries, participated in this study. The majority had >15 years of experience in MIS. Three (12...
January 1, 2017: Medicine, Science, and the Law
https://www.readbyqxmd.com/read/29027622/minimally-invasive-techniques-for-lumbar-decompressions-and-fusions
#18
REVIEW
Ankur S Narain, Fady Y Hijji, Jonathan S Markowitz, Krishna T Kudaravalli, Kelly H Yom, Kern Singh
PURPOSE OF REVIEW: The purpose of this study is to summarize the recent literature investigating the use of minimally invasive (MIS) techniques in the treatment of lumbar degenerative stenosis, spondylolisthesis, and scoliosis. RECENT FINDINGS: MIS lumbar decompression and fusion techniques for degenerative pathology are associated with reduced operative morbidity, shortened length of hospital stay, and reduced postoperative pain and narcotics utilization. Recent studies with long-term clinical follow-up have demonstrated equivalence in clinical outcomes between open and MIS surgical procedures...
October 11, 2017: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/29027285/subtle-deregulation-of-the-wnt-signaling-pathway-through-loss-of-apc2-reduces-the-fitness-of-intestinal-stem-cells
#19
Madeleine A Young, Carl S Daly, Elaine Taylor, Rhiannon James, Alan Richard Clarke, Karen Ruth Reed
The importance of the Wnt-signaling pathway on the regulation and maintenance of the intestinal stem cell (ISC) population is well recognized. However, our current knowledge base is founded on models using systems of gross deregulation of the Wnt-signaling pathway. Given the importance of this signaling pathway on intestinal homeostasis, there is a need to explore the role of more subtle alterations in Wnt-signaling levels within this tissue. Herein, we have used a model of Apc2 loss to meet this aim. Apc2 is a homolog of Apc which can also form a destruction complex capable of binding β-catenin, albeit less efficiently than Apc...
October 12, 2017: Stem Cells
https://www.readbyqxmd.com/read/29026550/making-mis-sense-of-asymptomatic-marked-hypercalcemia-in-pregnancy
#20
Giuseppe Maltese, Louise Izatt, Barbara M McGowan, Kashif Hafeez, Johnathan G Hubbard, Paul V Carroll
We describe a rare case of homozygous inactivating calcium-sensing receptor mutation detected during pregnancy and mimicking primary hyperparathyroidism. In pregnancy, the differential diagnosis of hypercalcaemia requires a cautious approach as physiological changes in calcium homeostasis may mask rare genetic conditions.
October 2017: Clinical Case Reports
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