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https://www.readbyqxmd.com/read/29676464/the-endosomal-recycling-of-fgsnc1-by-fgsnx41-fgsnx4-heterodimer-is-essential-for-polarized-growth-and-pathogenicity-in-fusarium-graminearum
#1
Wenhui Zheng, Yahong Lin, Wenqin Fang, Xu Zhao, Yi Lou, Guanghui Wang, Huawei Zheng, Qifu Liang, Yakubu Saddeeq Abubakar, Stefan Olsson, Jie Zhou, Zonghua Wang
Endosomal sorting machineries regulate the transport of their cargoes among intracellular compartments. However, the molecular nature of such intracellular trafficking processes in pathogenic fungal development and pathogenicity remains unclear. Here, we dissect the roles and molecular mechanisms of two sorting nexin proteins and their cargoes in endosomal recycling in Fusarium graminearum using high-resolution microscopy and high-throughput co-immunoprecipitation strategies. We show that the sorting nexins, FgSnx41 and FgSnx4, interact with each other and assemble into a functionally interdependent heterodimer through their respective BAR domains...
April 20, 2018: New Phytologist
https://www.readbyqxmd.com/read/29674228/error-analysis-of-speed-of-sound-reconstruction-in-ultrasound-limited-angle-transmission-tomography
#2
Rungroj Jintamethasawat, Won-Mean Lee, Paul L Carson, Fong Ming Hooi, J Brian Fowlkes, Mitchell M Goodsitt, Richard Sampson, Thomas F Wenisch, Siyuan Wei, Jian Zhou, Chaitali Chakrabarti, Oliver D Kripfgans
We have investigated limited angle transmission tomography to estimate speed of sound (SOS) distributions for breast cancer detection. That requires both accurate delineations of major tissues, in this case by segmentation of prior B-mode images, and calibration of the relative positions of the opposed transducers. Experimental sensitivity evaluation of the reconstructions with respect to segmentation and calibration errors is difficult with our current system. Therefore, parametric studies of SOS errors in our bent-ray reconstructions were simulated...
April 7, 2018: Ultrasonics
https://www.readbyqxmd.com/read/29673732/self-assessment-of-social-cognitive-ability-in-schizophrenia-association-with-social-cognitive-test-performance-informant-assessments-of-social-cognitive-ability-and-everyday-outcomes
#3
Juliet M Silberstein, Amy E Pinkham, David L Penn, Philip D Harvey
BACKGROUND: Impairments in self-assessment are common in people with schizophrenia and impairments in self-assessment of cognitive ability have been found to predict impaired functional outcome. In this study, we examined self-assessment of social cognitive ability and related them to assessments of social cognition provided by informants, to performance on tests of social cognition, and to everyday outcomes. The difference between self-reported social cognition and informant ratings was used to predict everyday functioning...
April 17, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29673371/radiographic-and-clinical-outcomes-following-mis-tlif-in-patients-with-adult-lumbar-degenerative-scoliosis
#4
Yongfei Zhao, Yan Liang, Keya Mao
BACKGROUND: Patients suffering from adult lumbar degenerative scoliosis (ALDS) are commonly complicated with advanced age, osteoporosis, cardiopulmonary insufficiency, and some other medical comorbidity. Therefore, the traditional open surgery can lead to high rate of postoperative complications. The purposes of this study were to introduce our experiences and explore the efficacy and feasibility of minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) in the treatment of patients with ALDS...
April 19, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29672610/threshold-dependent-repression-of-spl-gene-expression-by-mir156-mir157-controls-vegetative-phase-change-in-arabidopsis-thaliana
#5
Jia He, Mingli Xu, Matthew R Willmann, Kevin McCormick, Tieqiang Hu, Li Yang, Colby G Starker, Daniel F Voytas, Blake C Meyers, R Scott Poethig
Vegetative phase change is regulated by a decrease in the abundance of the miRNAs, miR156 and miR157, and the resulting increase in the expression of their targets, SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) transcription factors. To determine how miR156/miR157 specify the quantitative and qualitative changes in leaf morphology that occur during vegetative phase change, we measured their abundance in successive leaves and characterized the phenotype of mutations in different MIR156 and MIR157 genes. miR156/miR157 decline rapidly between leaf 1&2 and leaf 3 and decrease more slowly after this point...
April 19, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29672399/minimally-invasive-lobectomy-is-associated-with-lower-noncancer-specific-mortality-in-elderly-patients-a-propensity-score-matched-competing-risks-analysis
#6
Boris Hristov, Takashi Eguchi, Sarina Bains, Joe Dycoco, Kay See Tan, James M Isbell, Bernard J Park, David R Jones, Prasad S Adusumilli
OBJECTIVE: To investigate cancer- and noncancer-specific mortality following lobectomy by minimally invasive surgery (MIS) versus open thoracotomy in elderly patients with nonsmall cell lung cancer (NSCLC). BACKGROUND: Two-thirds of patients with NSCLC are ≥65 years of age. As age increases, the risk of competing events, such as noncancer death, also increases. METHODS: Elderly patients (≥65 yrs of age) who have undergone curative-intent lobectomy for stage I-III NSCLC without induction therapy (2002-2013) were included (n=1,303)...
April 18, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29671923/sucrose-assists-selection-of-high-quality-oocytes-in-pigs
#7
Thanh Quang Dang-Nguyen, Hiep Thi Nguyen, Tamas Somfai, David Wells, Nguyen Thi Men, Nguyen Viet-Linh, Junko Noguchi, Hiroyuki Kaneko, Kazuhiro Kikuchi, Takashi Nagai
We investigated whether high-quality in vitro matured (IVM) oocytes can be distinguished from poor ones based on the morphological changes after treatment with hyperosmotic medium containing 0.2 mol/L sucrose in pigs. We hypothesize that IVM oocytes maintaining round shape have higher quality than mis-shapened oocytes following dehydration. Oocyte quality was verified by determining embryonic developmental competence using in vitro fertilization, nuclear transfer and parthenogenetic activation. In all cases, the round oocytes had greater (p < ...
April 19, 2018: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/29671244/assessment-of-the-availability-cost-and-motivations-for-use-over-time-of-the-new-psychoactive-substances-benzodiazepines-diclazepam-flubromazepam-and-pyrazolam-in-the-uk
#8
Rachelle Abouchedid, Thea Gilks, Paul I Dargan, John R H Archer, David M Wood
INTRODUCTION: There has been increasing interest in the availability of non-prescription benzodiazepines and their sale as new psychoactive substances. We wanted to determine UK availability from Internet suppliers and motivations for use of three benzodiazepines (diclazepam, flubromazepam, and pyrazolam). METHODS: In November 2014 and March 2016, using the European Monitoring Centre for Drugs and Drug Addiction Snapshot Methodology, Internet search engines ( google...
April 18, 2018: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/29671108/comparison-of-pure-lateral-and-oblique-lateral-inter-body-fusion-for-treatment-of-lumbar-degenerative-disk-disease-a-multicentric-cohort-study
#9
Massimo Miscusi, Alessandro Ramieri, Stefano Forcato, Mary Giuffrè, Sokol Trungu, Marco Cimatti, Alessandro Pesce, Pietro Familiari, Amedeo Piazza, Cristina Carnevali, Giuseppe Costanzo, Antonino Raco
PURPOSE: The most effective interbody fusion technique for degenerative disk disease (DDD) is still controversial. The purpose of our study is to compare pure lateral (LLIF) and oblique lateral (OLIF) approaches for the treatment of lumbar DDD from L1-L2 to L4-L5, in terms of clinical and radiological outcomes. MATERIALS AND METHODS: 45 patients underwent lumbar interbody fusion for pure lumbar DDD from  L1-L2 to L4-L5 through LLIF (n = 31, mean age 62.1 years, range 45-78 years) or OLIF (n = 14, mean age 57...
April 18, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29667139/spinal-navigation-for-minimally-invasive-thoracic-and-lumbosacral-spine-fixation-implications-for-radiation-exposure-operative-time-and-accuracy-of-pedicle-screw-placement
#10
T Tajsic, K Patel, R Farmer, R J Mannion, R A Trivedi
PURPOSE: Navigation is emerging as a useful adjunct in percutaneous, minimally invasive spinal surgery (MIS). The aim of this study was to compare C-Arm navigated, O-Arm navigated and conventional 2D-fluoroscopy assisted MIS thoracic and lumbosacral spine fixation techniques in terms of operating time, radiation exposure and accuracy of pedicle screw (PS) placement. METHODS: Retrospective observational study of 152 consecutive adults who underwent MIS fixations for spinal instability: 96 2D-fluoroscopy assisted, 39 3D-C-Arm navigated and 27 using O-Arm navigated...
April 17, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29667041/perception-versus-reality-elucidating-motivation-and-expectations-of-current-fellowship-council-minimally-invasive-surgery-fellows
#11
Jeffrey R Watkins, Aurora D Pryor, Michael S Truitt, D Rohan Jeyarajah
BACKGROUND: The aim of our study is to determine minimally invasive trainee motivation and expectations for their respective fellowship. Minimally Invasive Surgery (MIS) is one of the largest non-ACGME post-residency training pathways though little is known concerning the process of residents choosing MIS as a fellowship focus. As general surgery evolves, it is important to understand resident motivation in order to better prepare them for a surgical career. METHODS: A survey invitation was sent to current trainees in the Minimally Invasive and related pathways through the Fellowship Council...
April 17, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29666963/minimally-invasive-surgery-and-percutaneous-surgery-of-the-hindfoot-and-midfoot
#12
Yves Stiglitz, Cyrille Cazeau
Minimally invasive surgery (MIS) and percutaneous (PC) surgery recently spread as a new technique in operative forefoot correction, and by extension in hindfoot and midfoot. Numerous procedures were described, and a race for MIS and PC has started. However, performing surgery with small incisions should not be an end in itself. Biomechanical and anatomical concerns must be taken into account and shall not be sacrificed for cosmetic reasons. For the most common hindfoot and midfoot pathologies, we discuss what we consider the surgical necessities and then describe the MIS and/or PC procedure we choose, according to these fundamentals...
April 17, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29665382/post-production-handling-and-administration-of-protein-pharmaceuticals-and-potential-instability-issues
#13
M Reza Nejadnik, Theodore W Randolph, David B Volkin, Christian Schöneich, John F Carpenter, Daan J A Crommelin, Wim Jiskoot
The safety and efficacy of protein pharmaceuticals depend not only on biological activity, but also on purity levels. Impurities may be process related due to limitations in manufacturing, or product related caused by protein degradation occurring throughout the life history of a product. Although the pharmaceutical biotechnology industry has made great progress in improving bulk and drug product manufacturing as well as company-controlled storage and transportation conditions to minimize the level of degradation, there is less control over the many factors that may subsequently affect product quality after the protein pharmaceuticals are released and shipped by the manufacturer...
April 14, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29665053/the-determinants-of-the-technical-efficiency-of-acute-inpatient-care-in-canada
#14
Li Wang, Michel Grignon, Sheril Perry, Xi-Kuan Chen, Alison Ytsma, Sara Allin, Katerina Gapanenko
OBJECTIVE: To evaluate the technical efficiency of acute inpatient care at the pan-Canadian level and to explore the factors associated with inefficiency-why hospitals are not on their production frontier. DATA SOURCES/STUDY SETTING: Canadian Management Information System (MIS) database (CMDB) and Discharge Abstract Database (DAD) for the fiscal year of 2012-2013. STUDY DESIGN: We use a nonparametric approach (data envelopment analysis) applied to three peer groups (teaching, large, and medium hospitals, focusing on their acute inpatient care only)...
April 17, 2018: Health Services Research
https://www.readbyqxmd.com/read/29661663/right-on-target
#15
Omer M Farhan-Alanie, David F Howie, Jonathan O'Reilly, Jacqui MacNair
Targets have become an integral part of health care, whether we agree with them or not. Many accept the progress made with the use of targets, but our duty as health professionals is to ensure that their use and interpretation is undertaken with the same care and understanding of their limitations that we apply to our clinical practice, and that they are not mis-interpreted or used to justify the latest political idioms. Currently the healthcare profession is failing to understand the consequences of setting targets, or the wider implications of hitting them...
April 13, 2018: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/29661575/outcomes-of-laparoscopic-resection-of-meckel-s-diverticulum-are-equivalent-to-open-laparotomy
#16
Brian Ezekian, Harold J Leraas, Brian R Englum, Brian F Gilmore, Christopher Reed, Tamara N Fitzgerald, Henry E Rice, Elisabeth T Tracy
PURPOSE: Meckel's diverticulum (MD) is a common congenital anomaly caused by failure of involution of the omphalomesenteric duct. Enthusiasm for minimally invasive surgery (MIS) in children has burgeoned as technologies have advanced, but the outcomes of laparoscopic resection in comparison to open laparotomy for MD remain poorly defined. We queried a large national database to compare current practice patterns and clinical outcomes between surgical approaches for MD in the pediatric population...
March 15, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29661151/n-terminal-pro-b-type-natriuretic-peptide-and-microsize-myocardial-infarction-risk-in-the-reasons-for-geographic-and-racial-differences-in-stroke-study
#17
Madeline R Sterling, Raegan W Durant, Joanna Bryan, Emily B Levitan, Todd M Brown, Yulia Khodneva, Stephen P Glasser, Joshua S Richman, George Howard, Mary Cushman, Monika M Safford
BACKGROUND: N-terminal pro B-type peptide (NT-proBNP) has been associated with risk of myocardial infarction (MI), but less is known about the relationship between NT-proBNP and very small non ST-elevation MI, also known as microsize MI. These events are now routinely detectable with modern troponin assays and are emerging as a large proportion of all MI. Here, we sought to compare the association of NT-proBNP with risk of incident typical MI and microsize MI in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study...
April 16, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29661140/the-biochemical-composition-and-transcriptome-of-cotyledons-from-brassica-napus-lines-expressing-the-atgl3-transcription-factor-and-exhibiting-reduced-flea-beetle-feeding
#18
Margaret Gruber, Ushan Alahakoon, Ali Taheri, Nayidu Nagubushana, Rong Zhou, Banyar Aung, Andrew Sharpe, Abdelali Hannoufa, Peta Bonham-Smith, Dwayne D Hegedus D
BACKGROUND: Previously, transgenic trichome-bearing (hairy leaf) Brassica napus lines expressing either the Arabidopsis thaliana GL3 gene (line AtGL3+) [1] or the AtGL3 gene in combination with an RNAi construct to down-regulate TTG1 (line K-5-8) [2] were developed. The leaves of these lines exhibited altered insect feeding (flea beetle) and oviposition (diamondback moth) behaviour compared to the non-transgenic semi-glabrous leaves of B. napus cv. Westar. Interestingly, the cotyledons of these lines remained glabrous, but also showed reduced feeding by flea beetles...
April 16, 2018: BMC Plant Biology
https://www.readbyqxmd.com/read/29659701/gain-of-function-mutation-of-atdice1-encoding-a-putative-endoplasmic-reticulum-localized-membrane-protein-causes-defects-in-anisotropic-cell-elongation-by-disturbing-cell-wall-integrity-in-arabidopsis
#19
Phi-Yen Le, Hyung-Woo Jeon, Min-Ha Kim, Eung-Jun Park, Hyoshin Lee, Indeok Hwang, Kyung-Hwan Han, Jae-Heung Ko
Background and Aims: Anisotropic cell elongation depends on cell wall relaxation and cellulose microfibril arrangement. The aim of this study was to characterize the molecular function of AtDICE1 encoding a novel transmembrane protein involved in anisotropic cell elongation in Arabidopsis. Methods: Phenotypic characterizations of transgenic Arabidopsis plants mis-regulating AtDICE1 expression with different pharmacological treatments were made, and biochemical, cell biological and transcriptome analyses were performed...
April 5, 2018: Annals of Botany
https://www.readbyqxmd.com/read/29657479/minimally-invasive-mis-t%C3%A3-nnis-osteotomy-a-technical-annotation-and-review-of-short-term-results
#20
Balasubramanian Balakumar, Malek Racy, Sanjeev Madan
Aims: We detail a modified single incision approach to perform the Tonnis triple pelvic osteotomy by a minimally invasive approach. Patients and Methods: 12 children underwent minimally invasive Tonnis Osteotomy. There were five boys and seven girls in this study group. Average age was 11 years (9-15 years) at the time of surgery. Mean follow-up was 20.5 months (13-39 months). Results: The average preoperative Antero-Posterior (AP) Centre Edge (CE) angle was -8...
March 2018: Journal of Orthopaedics
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