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https://www.readbyqxmd.com/read/28528146/prognostic-value-of-coronary-ct-angiography-with-selective-pet-perfusion-imaging-in-coronary-artery-disease
#1
Teemu Maaniitty, Iida Stenström, Jeroen J Bax, Valtteri Uusitalo, Heikki Ukkonen, Sami Kajander, Maija Mäki, Antti Saraste, Juhani Knuuti
OBJECTIVES: The purpose of this study was to evaluate the prognostic value of sequential hybrid imaging strategy in which positron emission tomography (PET) perfusion imaging is performed selectively in patients with suspected obstructive coronary artery disease (CAD) on coronary computed tomography angiography (CTA). BACKGROUND: Coronary CTA is an accurate diagnostic test for excluding obstructive CAD. However, the positive predictive value is suboptimal. METHODS: We investigated 864 consecutive symptomatic patients with intermediate probability of CAD who adhered to the sequential imaging approach...
May 15, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28524599/modulation-of-nuclear-rest-by-alternative-splicing-a-potential-therapeutic-target-for-huntington-s-disease
#2
Guo-Lin Chen, Qi Ma, Dharmendra Goswami, Jianyu Shang, Gregory M Miller
Huntington's disease (HD) is caused by a genetically mutated huntingtin (mHtt) protein with expanded polyQ stretch, which impairs cytosolic sequestration of the repressor element-1 silencing transcription factor (REST), resulting in excessive nuclear REST and subsequent repression of neuronal genes. We recently demonstrated that REST undergoes extensive, context-dependent alternative splicing, of which exon-3 skipping (∆E3 )-a common event in human and nonhuman primates-causes loss of a motif critical for REST nuclear targeting...
May 19, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28522367/qrs-t-wave-and-calcium-alternans-in-a-type-i-diabetic-mouse-model-for-spontaneous-post-myocardial-infarction-ventricular-tachycardia-a-mechanism-for-the-antiarrhythmic-effect-of-statins
#3
Hongwei Jin, Charles M Welzig, Mark Aronovitz, Farzad Noubary, Robert Blanton, Bo Wang, Mohammad Rajab, Alfred Albano, Mark S Link, Sami F Noujaim, Ho-Jin Park, Jonas B Galper
BACKGROUND: The incidence of sudden arrhythmic death is markedly increased in diabetics. OBJECTIVE: Develop a mouse model for Post MI VT in the diabetic heart and determine the mechanism of an antiarrhythmic effect of statins. METHODS: EKG transmitters were implanted in wild type (WT), placebo and pravastatin treated Type I diabetic Akita mice, MIs induced by coronary ligation, Ca(2+) transients studied by optical mapping, Ca(2+) transients and sparks in left VM (VM) by the Ionoptix system and confocal microscopy...
May 15, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28521682/repurposing-of-copper-ii-chelating-drugs-for-the-treatment-of-neurodegenerative-diseases
#4
Valeria Lanza, Danilo Milardi, Giuseppe Di Natale, Giuseppe Pappalardo
BACKGROUND: There is mounting urgency to find new drugs for the treatment of neurodegenerative disorders. A large number of reviews has exhaustively described either the molecular or clinical aspects of neurodegenerative diseases as Alzheimer's (AD) and Parkinson's (PD). Conversely, reports outlining how known drugs in use for other diseases can be also effective as therapeutic agents in neurodegenerative diseases are less reported. This review focuses on the current uses of some copper(II) interacting molecules as potential drug candidates in neurodegeneration...
May 17, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28520615/increased-risk-of-myocardial-infarction-in-hiv-infected-individuals-in-north-america-compared-to-the-general-population
#5
Daniel R Drozd, Mari M Kitahata, Keri N Althoff, Jinbing Zhang, Stephen J Gange, Sonia Napravnik, Greer A Burkholder, William C Mathews, Michael J Silverberg, Timothy R Sterling, Susan R Heckbert, Matthew J Budoff, Stephen Van Rompaey, Joseph A C Delaney, Cherise Wong, Weiqun Tong, Frank J Palella, Richard A Elion, Jeffrey N Martin, John T Brooks, Lisa P Jacobson, Joseph J Eron, Amy C Justice, Matthew S Freiberg, Daniel B Klein, Wendy S Post, Michael S Saag, Richard D Moore, Heidi M Crane
BACKGROUND: Previous studies of cardiovascular disease (CVD) among HIV-infected individuals have been limited by the inability to validate and differentiate atherosclerotic type 1 myocardial infarctions (T1MIs) from other events. We sought to define the incidence of T1MIs and risk attributable to traditional and HIV-specific factors among participants in the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD), and compare adjusted incidence rates to the general population Atherosclerosis Risk in Communities (ARIC) cohort...
May 17, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28516316/venous-thromboembolism-after-nephrectomy-incidence-timing-and-associated-risk-factors-from-a-national-multi-institutional-database
#6
Brian J Jordan, Richard S Matulewicz, Brian Trihn, Shilajit Kundu
PURPOSE: To evaluate the rate of venous thromboembolism (VTE) after nephrectomy with specific focus on event timing and location (before or after hospital discharge) in order to identify modifiable risk factors and establish benchmarks for preventive interventions. METHODS: Using the ACS-NSQIP database, we identified patients undergoing nephrectomy from 2006 to 2012. Patients were analyzed in two cohorts: collectively and by surgical approach [open vs. lap/robotic (MIS)]...
May 17, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28515002/electrocardiographic-qrs-t-angle-and-the-risk-of-incident-silent-myocardial-infarction-in-the-atherosclerosis-risk-in-communities-study
#7
Zhu-Ming Zhang, Pentti M Rautaharju, Ronald J Prineas, Larisa Tereshchenko, Elsayed Z Soliman
BACKGROUND: Silent myocardial infarction (SMI) accounts for about half of the total number of MIs, and is associated with poor prognosis as is clinically documented MI (CMI). The electrocardiographic (ECG) spatial QRS/T angle has been a strong predictor of cardiovascular outcomes. Whether spatial QRS/T angle also is predictive of SMI, and the easy-to-obtain frontal QRS/T angle will show similar association are currently unknown. METHODS: We examined the association between the spatial and frontal QRS/T angles, separately, with incident SMI among 9498 participants (mean age 54years, 57% women, and 20% African-American), who were free of cardiovascular disease at baseline (visit 1, 1987-1989) from the Atherosclerosis Risk in Communities (ARIC) study...
May 4, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28509824/implant-survival-after-minimally-invasive-anterior-or-anterolateral-vs-conventional-posterior-or-direct-lateral-approach-an-analysis-of-21-860-total-hip-arthroplasties-from-the-norwegian-arthroplasty-register-2008-to-2013
#8
Knut Erik Mjaaland, Svein Svenningsen, Anne Marie Fenstad, Leif I Havelin, Ove Furnes, Lars Nordsletten
BACKGROUND: Since 2008, there has been an increase in the use of minimally invasive surgery (MIS) through an anterior or anterolateral approach for total hip arthroplasty (THA) in Norway. We compared the MIS approaches with the conventional posterior and direct lateral approaches in terms of revision rates and risk of revision. METHODS: On the basis of data in the Norwegian Arthroplasty Register, 21,860 THAs with an uncemented stem, performed between 2008 and 2013, were identified and included in the cohort...
May 17, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28506412/rationality-in-prophylactic-central-neck-dissection-in-clinically-node-negative-cn0-papillary-thyroid-carcinoma-is-there-anything-more-to-say-a-decade-experience-in-a-single-center
#9
C Dobrinja, M Troian, T Cipolat Mis, G Rebez, S Bernardi, B Fabris, L Piscopello, P Makovac, F Di Gregorio, N de Manzini
AIM: Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy. Despite its extremely favorable prognosis, cervical lymph node metastases are a common feature of PTC and a known independent risk factor for local recurrence. However, the role of prophylactic central neck dissection (PCND) remains a matter of debate in patients with clinically node-negative (cN0) PTC. To better clarify the current role of PCND in the surgical treatment of PTC, evaluating advantages and disadvantages of PCND and outcome of cN0 PTC patients who have been treated with either total thyroidectomy alone or in combination with PCND...
May 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28505682/-implementation-of-a-laparoscopic-simulation-training-in-undergraduate-medical-education-the-l%C3%A3-beck-toolbox-curriculum
#10
Tilman Laubert, Michael Thomaschewski, Paul Auerswald, Markus Zimmermann, Linda Brüheim, Tobias Keck, Claudia Benecke
Background Simulation-based training has become increasingly relevant in minimally invasive surgery (MIS). It is unclear whether or not the established Lübeck Toolbox (LTB) Curriculum for the acquisition of basic MIS skills can be implemented to supplement standard undergraduate education in surgery and how it would be accepted. Materials und Methods Since 04/2015, students at the medical school of the University of Lübeck have had the option to complete the highly standardized and validated LTB Curriculum...
May 15, 2017: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/28505569/comparison-of-the-hologic-aptima-hiv-1-quant-dx-assay-to-the-roche-cobas-ampliprep-cobas-taqman-hiv-1-test-v2-0-for-the-quantification-of-hiv-1-rna-in-plasma-samples
#11
Kristian Schønning, Kim Johansen, Bodil Landt, Thomas Benfield, Henrik Westh
BACKGROUND: HIV-RNA is the most important parameter for monitoring antiviral treatment in individuals infected with HIV-1. Knowledge of the performance of different tests for the quantification of HIV-1 RNA is therefore important for clinical care. OBJECTIVES: To compare the analytical performance of the Aptima HIV-1 Quant Dx Assay (Aptima) and the COBAS Ampliprep/COBAS TaqMan HIV-1 Test v2.0 (CAPCTMv2) for the quantification of HIV-1 RNA in plasma samples. STUDY DESIGN: The performance of the two tests was compared on 216 clinical plasma samples, on dilutions series in seven replicates of five clinical samples of known subtype and on ten replicates of the Acrometrix High and Low Positive Control...
May 8, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/28505251/false-discovery-rate-control-incorporating-phylogenetic-tree-increases-detection-power-in-microbiome-wide-multiple-testing
#12
Jian Xiao, Hongyuan Cao, Jun Chen
Motivation: Next generation sequencing technologies have enabled the study of the human microbiome through direct sequencing of microbial DNA, resulting in an enormous amount of microbiome sequencing data. One unique characteristic of microbiome data is the phylogenetic tree that relates all the bacterial species. Closely related bacterial species have a tendency to exhibit a similar relationship with the environment or disease. Thus, incorporating the phylogenetic tree information can potentially improve the detection power for microbiome-wide association studies, where hundreds or thousands of tests are conducted simultaneously to identify bacterial species associated with a phenotype of interest...
May 13, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28504524/healthy-aging-is-associated-with-decreased-risk-taking-in-motor-decision-making
#13
Matteo Valsecchi, Jutta Billino, Karl R Gegenfurtner
Healthy aging is associated with changes in both cognitive abilities, including decision-making, and motor control. Previous research has shown that young healthy observers are close to optimal when they perform a motor equivalent of economic decision-making tasks that are known to produce suboptimal decision patterns. We tested both younger (age 20-29) and older (age 60-79) adults in such a task, which involved rapid manual aiming and monetary rewards and punishments contingent on hitting different areas on a touch screen...
May 15, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/28500767/metformin-for-high-altitude-performance
#14
Martin Burtscher
Metformin has been introduced for treatment of type 2 diabetes but may also have ergogenic properties at high altitude by improving muscle glycogen repletion. However, very little information is available on potential risks associated with the (mis)use of metformin by healthy people. This article is protected by copyright. All rights reserved.
May 13, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28499016/minimally-invasive-transforaminal-lumbar-interbody-fusion-using-banana-shaped-and-straight-cages-radiological-and-clinical-results-from-a-prospective-randomized-clinical-trial
#15
Won-Suh Choi, Jin-Sung Kim, Jung-Woo Hur, Ji-Hoon Seong
BACKGROUND: In minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF), cage type and position play important roles in fusion achievement and sagittal alignment correction. However, no prospective randomized comparison of the results using different types of cage has been reported to date. OBJECTIVE: To compare the radiological and clinical outcomes of unilateral MIS-TLIF using 2 types of cage. METHODS: All candidates for single-level MIS-TLIF were randomized into banana-shaped cage and straight-cage groups...
May 10, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28498966/genprobis-web-server-for-mapping-of-sequence-variants-to-protein-binding-sites
#16
Janez Konc, Blaz Skrlj, Nika Erzen, Tanja Kunej, Dusanka Janezic
Discovery of potentially deleterious sequence variants is important and has wide implications for research and generation of new hypotheses in human and veterinary medicine, and drug discovery. The GenProBiS web server maps sequence variants to protein structures from the Protein Data Bank (PDB), and further to protein-protein, protein-nucleic acid, protein-compound, and protein-metal ion binding sites. The concept of a protein-compound binding site is understood in the broadest sense, which includes glycosylation and other post-translational modification sites...
May 11, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28498489/application-of-edible-films-containing-oregano-origanum-vulgare-essential-oil-on-queso-blanco-cheese-prepared-with-flaxseed-linum-usitatissimum-oil
#17
Cristhiam Gurdian, Alexander Chouljenko, Kevin Mis Solval, Charles Boeneke, Joan M King, Subramaniam Sathivel
Fortification of queso blanco (QB) with flaxseed oil (FO) containing omega-3 polyunsaturated fatty acids may provide a functional food with health benefits such as improved cell, brain, and retina functionality, and protection against cardiovascular and immune-inflammatory diseases. However, QB experiences a short shelf life because of the early development of yeasts and molds and addition of FO may increase susceptibility to lipid oxidation. Oregano essential oil (OEO) is known for its antimicrobial and antioxidant properties, but due to its intense flavor compounds it may not be suitable for direct incorporation into QB...
May 12, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28498235/hospital-minimally-invasive-surgery-utilization-for-gastrointestinal-cancer
#18
Meredith C Mason, Hop S Tran Cao, Samir S Awad, Farhood Farjah, George J Chang, Nader N Massarweh
OBJECTIVE: The aim of the study was to evaluate the impact of receiving care at high minimally invasive surgery (MIS)-utilizing hospitals BACKGROUND:: MIS techniques are used across surgical specialties. The extent of MIS utilization for gastrointestinal (GI) cancer resection and impact of receiving care at high utilizing hospitals is unclear. METHODS: This is a retrospective cohort study of 137,581 surgically resected esophageal, gastric, pancreatic, hepatobiliary, colon, and rectal cancer patients within the National Cancer Data Base (2010-2013)...
May 11, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28496112/-tornado-theranostic-one-step-rna-detector-microfluidic-disc-for-the-direct-detection-of-microrna-134-in-plasma-and-cerebrospinal-fluid
#19
Hazel McArdle, Eva M Jimenez-Mateos, Rana Raoof, Eadaoin Carthy, David Boyle, Hany ElNaggar, Norman Delanty, Hajo Hamer, Muejgdan Dogan, Tessa Huchtemann, Peter Kӧrtvelyessy, Felix Rosenow, Robert J Forster, David C Henshall, Elaine Spain
Diagnosis of seizure disorders such as epilepsy currently relies on clinical examination and electroencephalogram recordings and is associated with substantial mis-diagnosis. The miRNA, miR-134 (MIR134 in humans), has been found to be elevated in brain tissue after experimental status epilepticus and in human epilepsy cells and their detection in biofluids may serve as unique biomarkers. miRNAs from unprocessed human plasma and human cerebrospinal fluid samples were used in a novel electrochemical detection based on electrocatalytic platinum nanoparticles inside a centrifugal microfluidic device where the sandwich assay is formed using an event triggered release system, suitable for the rapid point-of-care detection of low abundance biomarkers of disease...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28493303/comprehensive-profiling-of-rhizome-associated-alternative-splicing-and-alternative-polyadenylation-in-moso-bamboo-phyllostachys-edulis
#20
Taotao Wang, Huiyuan Wang, Dawei Cai, Yubang Gao, Hangxiao Zhang, Yongsheng Wang, Chentao Lin, Liuyin Ma, Lianfeng Gu
Moso bamboo (Phyllostachys edulis) represents one of the fastest-spreading plants in the world, due in part to their well-developed rhizomes system. However, the post-transcriptional mechanism has not been comprehensively studied for the development of rhizome system in bamboo. We therefore used a combination of single-molecule long-read sequencing technology and polyadenylation site sequencing (PAS-seq) to re-annotate the bamboo genome, and genome-wide identify alternative splicing (AS) and alternative polyadenylation (APA) in the rhizomes system...
May 10, 2017: Plant Journal: for Cell and Molecular Biology
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