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Falguni Parikh
Febrile patient with thrombocytopenia is commonly encountered by physicians especially during monsoon and perimonsoon period. Infections with protozoa, bacteria and viruses can cause thrombocytopenia with or without disseminated intravascular coagulation. Commonly dengue, malaria, scrub typhus and other rickettsial infections, meningococci, leptospira and certain viral infections present as fever with thrombocytopenia. Occasionally these patients can go on to develop a stormy course with multiorgan dysfunction requiring intensive care unit admission associated with high morbidity and mortality...
February 2016: Journal of the Association of Physicians of India
Vrinda V, V T Premkumar, M Sooriyakumar, K Muralidharan, S Sivarama Subramaniyan
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Jun Hirai, Takeshi Kinjo, Takaaki Tome, Mao Hagihara, Daisuke Sakanashi, Hideta Nakamura, Shusaku Haranaga, Hiroshige Mikamo, Jiro Fujita
Neisseria meningitidis often causes meningitis and meningococcemia; however, meningococcal pneumonia is quite rare. Herein, we report a case of non-invasive meningococcal pneumonia initially misdiagnosed as pneumonia due to Moraxella catarrhalis on the basis of a Gram stain in a 43-year-old woman with asthma, type 2 diabetes mellitus, and schizophrenia. She visited our hospital following a 3-day history of fever, productive cough, and shortness of breath. Since her sputum smear revealed Gram-negative diplococcus and the chest radiograph showed infiltration in the lower right lung field, her initial diagnosis was pneumonia caused by M...
August 31, 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
M Thimmesch, E Bodart, P Gavage, J-P Misson, J Frère
INTRODUCTION: Neisseria meningitidis is a Gram-negative bacteria that can be highly pathogenic in humans and responsible for life-threatening and acute diseases. In a few cases, it can lead to an atypical form of sepsis-acute, subacute, or chronic-which, even if progression is slower, may carry the same risks for patients as conventional acute forms. CASES: Case 1 presented with recurrent fever, polyarthralgia, and generalized macular rash. Case 2 had fever for the previous 10days with neck pain and macular rash...
June 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
Clara Franco-Jarava, Roger Colobran, Jaume Mestre-Torres, Victor Vargas, Ricardo Pujol-Borrell, Manuel Hernández-González
Complement factor I (CFI) deficiency is typically associated to recurrent infections with encapsulated microorganisms and, less commonly, to autoimmunity. We report a 53-years old male who, in a routine control for non-alcoholic fatty liver disease, presented a flat beta-2 fraction at the capillary protein electropherogram. Patient's clinical records included multiple oropharyngeal infections since infancy and an episode of invasive meningococcal infection. Complement studies revealed reduced C3, low classical pathway activation and undetectable Factor I...
June 2016: Immunology Letters
Susana Hernando Real, Silvia Vega Castaño, Rafael Pajares García
No abstract text is available yet for this article.
March 16, 2016: Enfermedades Infecciosas y Microbiología Clínica
Shimon Takada, Sho Fujiwara, Toshiya Inoue, Yuki Kataoka, Yoshiro Hadano, Kentaro Matsumoto, Kyoko Morino, Taro Shimizu
We mainly refer to the acute setting of meningococcemia. Meningococcemia is an infection caused by Neisseria meningitidis, which has 13 clinically significant serogroups that are distinguishable by the structure of their capsular polysaccharides. N. meningitidis, also called meningococcus, is a Gram-negative, aerobic, diplococcus bacterium. The various consequences of severe meningococcal sepsis include hypotension, disseminated intravascular coagulation (DIC), multiple organ failure, and osteonecrosis due to DIC...
2016: Internal Medicine
Gulcan Seymen Karabulut, Turker Acar, Aysegul Bute Yuksel, Yasemin Alanay, Şükrü Hatun
No abstract text is available yet for this article.
June 2016: Journal of Pediatrics
Daniel Lachant, David Trawick
Neisseria meningitidis is an encapsulated gram negative diplococcus that colonizes the nasopharynx and is transmitted by aerosol or secretions with the majority of cases occurring in infants and adolescents. Meningococcemia carries a high mortality which is in part due to myocarditis. Early recognition and prompt use of antibiotics improve morbidity and mortality. We report a 55-year-old male presenting to the emergency department with chest pain, shortness of breath, and electrocardiogram changes suggestive of ST elevation MI who developed cardiogenic shock and multisystem organ failure from N...
2015: Case Reports in Critical Care
Isabel Matute, Andrea Olea, Darío López, Sergio Loayza, Manuel Nájera, Claudia González, Lucy Poffald, Macarena Hirmas, Iris Delgado, Elena Pedroni, Tania Alfaro, Ana María Gormaz, Gabriel Sanhueza, Pablo Vial, Jeannette Dabanch, Doris Gallegos, Ximena Aguilera
INTRODUCTION: Meningococcal disease (MD) is a major global problem because of its case fatality rate and sequels. Since 2012 cases of serogroup W have increased in Chile, with nonspecific clinical presentation, high case fatality rate and serious consequences. OBJECTIVE: To characterize the evolution and outcome of MD cases between January 2012 and March 2013 in Chile. MATERIAL AND METHODS: Case series considering 149 MD cases of 7 regions...
October 2015: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
F Poizeau, M Cormerais, L Darrieux, S Ricordel, G Garnier, G Safa
INTRODUCTION: Meningococcemia without meningitis is an often under recognized clinical form of invasive Neisseria meningitidis infection. CASE REPORTS: We report two unusual cases of invasive meningococcal disease who presented with meningococcemia without distinct signs of meningitis or severe sepsis manifestation. In both cases, confirmation of the diagnosis is provided by meningococcal PCR performed on blood or skin lesion biopsy. CONCLUSION: Clinical recognition of this entity is crucial for early antibiotic treatment and to avoid delayed diagnosis and potentially dangerous complications...
March 2016: La Revue de Médecine Interne
Cynthia A Bonville, Manika Suryadevara, Olamide Ajagbe, Joseph B Domachowske
Chronic meningococcemia is a rare diagnosis seen in patients with recurrent fever and rash. We describe a case of chronic meningococcemia in a teenage girl who presented with a recurrent painful rash, without fever, over a period of 8 weeks.
June 2015: Pediatric Infectious Disease Journal
Jeroen Christiaan de Jonge, Klaas Koop, Mente Bousema, Roos Nuboer
BACKGROUND: Fever with a rash is a common clinical presentation, which can be caused by various medical conditions. CASE DESCRIPTION: A 14-year old boy presented at the outpatient clinic with a two-week history of fever, myalgia and purpuric skin lesions. Blood cultures showed an infection with Neisseria meningitidis. After antibiotic treatment, his symptoms resolved promptly. CONCLUSION: Chronic meningococcemia is a rare manifestation of meningococcal infection and should be considered in patients with prolonged fever, purpuric skin lesions and joint involvement...
2015: Nederlands Tijdschrift Voor Geneeskunde
Ryan P Austin, Adam G Field, William M Beer
No abstract text is available yet for this article.
November 2015: American Journal of Emergency Medicine
Shin Nihonyanagi, Keisuke Sunakawa, Longzhu Cui, Tsuguto Masaki, Tatsuhiko Wada, Takayuki Hoshiyama, Masaki Nakamura, Yoko Takayama, Yuhsaku Kanoh, Akifumi Ogawa, Masayoshi Shichiri, Hideaki Hanaki
We report here a very rare case of primary meningococcal arthritis of the knee joint without clinical features associated with meningococcemia, meningitis, or meningococcal complications. The patient suffered from diabetes mellitus and had experienced two episodes of joint trauma. Intravenous infusion of ampicillin/sulbactam for 18 consecutive days was successful.
February 2015: Clinical Case Reports
Zheng Xu, Bingqing Zhu, Li Xu, Yuan Gao, Zhujun Shao
Invasive meningococcal diseases are rarely caused by capsule null locus (cnl) strains, which are unencapsulated owing to an absence of capsule synthesis genes. Only a few cases of cnl meningococcemia in severely immunocompromised patients have been reported. Here, we describe and discuss the first case of invasive disease in an immunocompetent patient due to a cnl strain of Neisseria meningitidis in China. We characterize this strain and discuss the special ST-198 complex of cnl.
August 2015: Infectious Diseases
Cristián Vera-Kellet, Constanza Del Puerto, Felipe Ruiz, Sergio González, Jorge Manríquez
Septic vasculitis is a medium and small-vessel vasculitis caused by direct action of pathogens, associated with bacteremia. It is an uncommon condition; clinical manifestations include purpura, ulcers and vesicles-pustules. Most cases of septic vasculitis are related to meningococcemia. There are no cases reported in medical literature associated to Listeria spp. We report a case of a 71 year-old man who presented sepsis by Listeria monocytogenes, and then evolved with purpuric skin lesions. Skin biopsy revealed a septic vasculitis...
December 2014: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
Daniel J Mollura, Tara N Palmore, Les R Folio, David A Bluemke
The overlap of early Ebola virus disease (EVD) symptoms (eg, fever, headache, abdominal pain, diarrhea, emesis, and fatigue) with symptoms of other more common travel-related diseases (eg, malaria, typhoid fever, pneumonia, and meningococcemia) may result in delayed diagnosis of EVD before isolation of infected patients. Radiology departments should consider policies for and approaches to decontamination of expensive and potentially easily damaged radiology equipment. In addition, the protection of radiology personnel must be considered during the work-up phase of undiagnosed EVD patients presenting to emergency departments...
May 2015: Radiology
C Tomasini
Sepsis is a potentially life-threatening complication of an infection where cutaneous lesions often represent one of the early signs. A myriad of microorganisms including bacteria, fungi, yeasts, viruses, protozoas, helminths and algae can be implicated. A broad spectrum of clinical and histopathologic findings can be observed in the skin and the common denominator is a thrombotic vasculopathy. The pathogenesis of cutaneous septic vasculitis (SV)/vasculopathy is complex and includes five main mechanisms: disseminated intravascular coagulation, direct invasion and occlusion of blood vessel walls by microorganisms, hypersensitivity reaction with immune complex deposition into blood vessel walls, embolism from a distant infectious site and vascular effects of toxins...
February 2015: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
A Ruiz-Serrato, J Villar-Jiménez, J Olmedo-Llanes, M C Almodóvar-Pulido, J J Carabantes-Rueda, M A García-Ordóñez
Meningococcal disease is caused by hematogenous spreading of Neisseria meningitidis. Meningococcal sepsis occurs in around 20% of cases of meningococcal disease, meningitis in 50% and, to a lesser extent, other conditions such as pneumonia, arthritis, urethritis, conjunctivitis or pericarditis. Brain abscesses are a rare complication.
September 2014: Anales del Sistema Sanitario de Navarra
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