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https://www.readbyqxmd.com/read/28904187/genomic-characterization-of-urethritis-associated-neisseria-meningitidis-shows-that-a-wide-range-of-n-meningitidis-strains-can-cause-urethritis
#1
Kevin C Ma, Magnus Unemo, Samo Jeverica, Robert D Kirkcaldy, Hideyuki Takahashi, Makoto Ohnishi, Yonatan H Grad
Neisseria meningitidis, typically a resident of the oro- or nasopharynx and the causative agent of meningococcal meningitis and meningococcemia, is capable of invading and colonizing the urogenital tract. This can result in urethritis, akin to the syndrome caused by its sister species N. gonorrhoeae, the etiologic agent of gonorrhea. Recently, meningococcal strains associated with outbreaks of urethritis were reported to share genetic characteristics with gonococcus, raising the question of the extent to which these strains contain features that promote adaptation to the genitourinary niche, making them gonococcal-like and distinguishing them from other N...
September 13, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28808592/a-case-of-fulminant-meningococcemia-it-is-all-in-the-complement
#2
Kellie L Hawkins, Mariah Hoffman, Sonia Okuyama, Sarah E Rowan
Eculizumab is a novel monoclonal antibody that inhibits complement-mediated hemolysis in patients with paroxysmal nocturnal hemoglobinuria (PNH). Complement deficiency is a well-known risk factor for meningococcal infection. We describe a case of a young patient with PNH treated with eculizumab who presented with a life-threatening case of nongroupable meningococcemia. As this new biologic agent becomes more widely prescribed, providers should be aware of the increased risk of meningococcemia. In addition to vaccination, providers may consider the use of oral penicillin for antibiotic prophylaxis against Neisseria meningitidis in these cases of functional complement deficiency...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28723791/arthritis-secondary-to-meningococcal-disease-a-case-series-of-7-patients
#3
MULTICENTER STUDY
Vanina Masson-Behar, Hervé Jacquier, Pascal Richette, Jean-Marc Ziza, Valérie Zeller, Christophe Rioux, Baptiste Coustet, Philippe Dieudé, Sébastien Ottaviani
Arthritis secondary to invasive meningococcemia is rare and has been described as a direct result of bacteremia or as immunoallergic-type arthritis, related to the immune complex. Only a few case series have been reported.This multicenter study aimed to describe the clinical characteristics and therapeutic outcomes of arthritis secondary to meningococcal infection.We performed a 5-year retrospective study. We included all patients with inflammatory joint symptoms and proven meningococcal disease defined by the identification of Neisseria meningitidis in blood, cerebrospinal fluid, or synovial fluid...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28441232/atriobronchial-fistula-complicated-by-septic-cerebral-air-emboli-after-pulmonary-vein-ablation
#4
David Velghe, Thomas Apers, Stefanie Devriendt, Ivo Deblier, Bart Hendriks, Rogier Nieuwendijk, Peter Rogiers
OBJECTIVE: To describe a case of an infected atriobronchial fistula as a late complication after pulmonary vein ablation, leading to septic air emboli and requiring urgent cardiac surgery. DATA SOURCES: Clinical observation. STUDY SELECTION: Case report. DATA EXTRACTION: Relevant clinical information. PubMed was searched for relevant literature. DATA SYNTHESIS: Given its high success and low complication rate, pulmonary vein isolation is expected to be increasingly performed worldwide...
August 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28271045/fulminant-meningococcemia
#5
Diana Fidrocki, Larry Lutwick
No abstract text is available yet for this article.
2017: IDCases
https://www.readbyqxmd.com/read/28236134/purpura-fulminans-in-acute-meningococcemia
#6
Siwadon Pitukweerakul, Pavel Sinyagovskiy, Pye Phyo Aung
No abstract text is available yet for this article.
July 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/27902653/meningococcal-disease-in-children-in-argentina-a-3-year-active-sentinel-hospital-surveillance-study
#7
Ángela Gentile, Julia Bakir, María Rosa Agosti, Gabriela Ensinck, Hector Abate, Andrea Gajo Gane, Alejandro Santillán Iturres, Adriana Efron, Mabel Regueira, Ricardo Rüttimann
BACKGROUND: Meningococcal disease (MD) is a medical emergency and a serious public health problem. As new meningococcal vaccines become available, MD surveillance is crucial to provide baseline epidemiologic data before implementing preventive measures. We estimated MD incidence and epidemiology in Argentina using hospital-based surveillance. METHODS: Three-year prospective active surveillance in patients ≤15 years of age was conducted at 6 pediatric hospital sentinel units (March 2012 to February 2015)...
March 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27830356/successful-treatment-of-a-patient-with-ethylmalonic-encephalopathy-by-intravenous-n-acetylcysteine
#8
Mustafa Kılıç, Özge Dedeoğlu, Rahşan Göçmen, Selman Kesici, Deniz Yüksel
Ethylmalonic encephalopathy (EE) is an autosomal recessive devastating metabolic disorder affecting the brain, gastrointestinal tract, peripheral vessels and rarely the other vascular organs. We report a 10-month-old girl who presented as a meningococcemia clinic but later diagnosed ethylmalonic encephalopathy. Molecular analyses revealed a homozygous c.554 T > G; p. L185R mutation in ETHE1 gene. She was only partially benefited from riboflavine, coenzyme Q10, metronidazole, N-acetylcysteine and symptomatic treatment and discharged from hospital with the sequela of oxygene dependance and developmental delay...
April 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/27730774/infections-and-thrombocytopenia
#9
EDITORIAL
Falguni Parikh
Febrile patient with thrombocytopenia is commonly encountered by physicians especially during monsoon and perimonsoon period. Infections with protozoa, bacteria and viruses can cause thrombocytopenia with or without disseminated intravascular coagulation. Commonly dengue, malaria, scrub typhus and other rickettsial infections, meningococci, leptospira and certain viral infections present as fever with thrombocytopenia. Occasionally these patients can go on to develop a stormy course with multiorgan dysfunction requiring intensive care unit admission associated with high morbidity and mortality...
February 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27728401/a-rare-case-of-chronic-meningococcemia
#10
Vrinda V, V T Premkumar, M Sooriyakumar, K Muralidharan, S Sivarama Subramaniyan
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27591787/meningococcal-pneumonia-in-japan-a-case-report-and-literature-review
#11
Jun Hirai, Takeshi Kinjo, Takaaki Tome, Mao Hagihara, Daisuke Sakanashi, Hideta Nakamura, Shusaku Haranaga, Hiroshige Mikamo, Jiro Fujita
Neisseria meningitidis often causes meningitis and meningococcemia; however, meningococcal pneumonia is quite rare. Herein, we report a case of non-invasive meningococcal pneumonia initially misdiagnosed as pneumonia due to Moraxella catarrhalis on the basis of a Gram stain in a 43-year-old woman with asthma, type 2 diabetes mellitus, and schizophrenia. She visited our hospital following a 3-day history of fever, productive cough, and shortness of breath. Since her sputum smear revealed Gram-negative diplococcus and the chest radiograph showed infiltration in the lower right lung field, her initial diagnosis was pneumonia caused by M...
December 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/27133366/-two-case-reports-of-meningococcemia-review-of-the-literature-on-chronic-meningococcemia
#12
REVIEW
M Thimmesch, E Bodart, P Gavage, J-P Misson, J Frère
INTRODUCTION: Neisseria meningitidis is a Gram-negative bacteria that can be highly pathogenic in humans and responsible for life-threatening and acute diseases. In a few cases, it can lead to an atypical form of sepsis-acute, subacute, or chronic-which, even if progression is slower, may carry the same risks for patients as conventional acute forms. CASES: Case 1 presented with recurrent fever, polyarthralgia, and generalized macular rash. Case 2 had fever for the previous 10days with neck pain and macular rash...
June 2016: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/27091480/clinical-laboratory-standard-capillary-protein-electrophoresis-alerted-of-a-low-c3-state-and-lead-to-the-identification-of-a-factor-i-deficiency-due-to-a-novel-homozygous-mutation
#13
Clara Franco-Jarava, Roger Colobran, Jaume Mestre-Torres, Victor Vargas, Ricardo Pujol-Borrell, Manuel Hernández-González
Complement factor I (CFI) deficiency is typically associated to recurrent infections with encapsulated microorganisms and, less commonly, to autoimmunity. We report a 53-years old male who, in a routine control for non-alcoholic fatty liver disease, presented a flat beta-2 fraction at the capillary protein electropherogram. Patient's clinical records included multiple oropharyngeal infections since infancy and an episode of invasive meningococcal infection. Complement studies revealed reduced C3, low classical pathway activation and undetectable Factor I...
June 2016: Immunology Letters
https://www.readbyqxmd.com/read/26994815/meningococcemia-in-vaccinated-patient-under-treatment-with-eculizumab
#14
Susana Hernando Real, Silvia Vega Castaño, Rafael Pajares García
No abstract text is available yet for this article.
March 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/26984070/meningococcemia-in-adults-a-review-of-the-literature
#15
REVIEW
Shimon Takada, Sho Fujiwara, Toshiya Inoue, Yuki Kataoka, Yoshiro Hadano, Kentaro Matsumoto, Kyoko Morino, Taro Shimizu
We mainly refer to the acute setting of meningococcemia. Meningococcemia is an infection caused by Neisseria meningitidis, which has 13 clinically significant serogroups that are distinguishable by the structure of their capsular polysaccharides. N. meningitidis, also called meningococcus, is a Gram-negative, aerobic, diplococcus bacterium. The various consequences of severe meningococcal sepsis include hypotension, disseminated intravascular coagulation (DIC), multiple organ failure, and osteonecrosis due to DIC...
2016: Internal Medicine
https://www.readbyqxmd.com/read/26960252/late-sequel-of-meningococcemia-skeletal-dysplasia
#16
Gulcan Seymen Karabulut, Turker Acar, Aysegul Bute Yuksel, Yasemin Alanay, Şükrü Hatun
No abstract text is available yet for this article.
June 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/26640720/meningococcemia-presenting-as-a-myocardial-infarction
#17
Daniel Lachant, David Trawick
Neisseria meningitidis is an encapsulated gram negative diplococcus that colonizes the nasopharynx and is transmitted by aerosol or secretions with the majority of cases occurring in infants and adolescents. Meningococcemia carries a high mortality which is in part due to myocarditis. Early recognition and prompt use of antibiotics improve morbidity and mortality. We report a 55-year-old male presenting to the emergency department with chest pain, shortness of breath, and electrocardiogram changes suggestive of ST elevation MI who developed cardiogenic shock and multisystem organ failure from N...
2015: Case Reports in Critical Care
https://www.readbyqxmd.com/read/26633106/-clinical-features-and-prognostic-factors-of-meningococcal-disease-a-case-series-study-in-chile-during-the-2012-2013-outbreak
#18
Isabel Matute, Andrea Olea, Darío López, Sergio Loayza, Manuel Nájera, Claudia González, Lucy Poffald, Macarena Hirmas, Iris Delgado, Elena Pedroni, Tania Alfaro, Ana María Gormaz, Gabriel Sanhueza, Pablo Vial, Jeannette Dabanch, Doris Gallegos, Ximena Aguilera
INTRODUCTION: Meningococcal disease (MD) is a major global problem because of its case fatality rate and sequels. Since 2012 cases of serogroup W have increased in Chile, with nonspecific clinical presentation, high case fatality rate and serious consequences. OBJECTIVE: To characterize the evolution and outcome of MD cases between January 2012 and March 2013 in Chile. MATERIAL AND METHODS: Case series considering 149 MD cases of 7 regions...
October 2015: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/26338027/-meningococcemia-without-meningitis-a-report-of-two-cases
#19
F Poizeau, M Cormerais, L Darrieux, S Ricordel, G Garnier, G Safa
INTRODUCTION: Meningococcemia without meningitis is an often under recognized clinical form of invasive Neisseria meningitidis infection. CASE REPORTS: We report two unusual cases of invasive meningococcal disease who presented with meningococcemia without distinct signs of meningitis or severe sepsis manifestation. In both cases, confirmation of the diagnosis is provided by meningococcal PCR performed on blood or skin lesion biopsy. CONCLUSION: Clinical recognition of this entity is crucial for early antibiotic treatment and to avoid delayed diagnosis and potentially dangerous complications...
March 2016: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/25970111/chronic-meningococcemia-presenting-as-a-recurrent-painful-rash-without-fever-in-a-teenage-girl
#20
Cynthia A Bonville, Manika Suryadevara, Olamide Ajagbe, Joseph B Domachowske
Chronic meningococcemia is a rare diagnosis seen in patients with recurrent fever and rash. We describe a case of chronic meningococcemia in a teenage girl who presented with a recurrent painful rash, without fever, over a period of 8 weeks.
June 2015: Pediatric Infectious Disease Journal
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