keyword
https://read.qxmd.com/read/37682248/maturation-of-metastases-in-peripheral-neuroblastic-tumors-neuroblastoma-of-children
#21
JOURNAL ARTICLE
Harvey B Sarnat, Elaine S Chan, Denise Ng, Weiming Yu
Peripheral neuroblastic tumors of childhood exhibit 3 principal neural crest lineages: primitive neuroblastoma, ganglioneuroblastoma, and ganglioneuroma. They are unique in undergoing maturation of neurons (ganglion cells) and Schwann cells, thereby recapitulating normal fetal neuronal development in the brain. Precision in estimating neurogenesis is enhanced by immunoreactivities of markers of neuronal maturation. Whether organ tissue factors in different sites of metastases influence rates of maturation and whether metastases are similar to their primary neuroblastic tumor are incompletely documented...
September 8, 2023: Journal of Neuropathology and Experimental Neurology
https://read.qxmd.com/read/37608330/translational-practice-of-fluorescence-in-situ-hybridisation-to-identify-neuroblastic-tumours-with-tert-rearrangements
#22
JOURNAL ARTICLE
Yongbo Yu, Meng Zhang, Xingfeng Yao, Xiaoxing Guan, Chao Jia, Ping Chu, Ruqian Zhang, Yeran Yang, Yaqiong Jin, Huanmin Wang, Xin Ni, Lejian He, Yongli Guo
Recently, telomerase reverse transcriptase (TERT) gene rearrangements have been identified in neuroblastoma (NB), the typical pathological type of neuroblastic tumours (NTs); however, the prevalence of TERT rearrangements in other types of NT remains unknown. This study aimed to develop a practical method for detecting TERT defects and to evaluate the clinical relevance of TERT rearrangements as a biomarker for NT prognosis. A TERT break-apart probe for fluorescence in situ hybridisation (FISH) was designed, optimised, and applied to assess the genomic status of TERT in Chinese children with NTs at the Beijing Children's Hospital from 2016 to 2019...
August 22, 2023: Journal of Pathology. Clinical Research
https://read.qxmd.com/read/37586852/cervical-ganglioneuroblastoma-diagnosed-by-68-ga-dotatoc-pet-ct-in-a-child-with-opsoclonus-myoclonus-syndrome
#23
JOURNAL ARTICLE
Kusai Al-Muqbel, Hamza Alardah, Ruba Al-Smadi, Sohaib Al-Khatib, Raya Abughanmi
We performed a 68 Ga-DOTATOC PET/CT scan on a 25-mo-old female patient who presented with opsoclonus myoclonus ataxia syndrome and had negative initial anatomic imaging. The scan showed a somatostatin receptor-overexpressing cervical tumor in favor of a cervical neuroendocrine tumor, with subsequent histopathologic findings of ganglioneuroblastoma.
August 16, 2023: Journal of Nuclear Medicine Technology
https://read.qxmd.com/read/37560203/clinicopathological-significance-of-vasculogenic-mimicry-and-fetal-hemoglobin-expression-in-peripheral-neuroblastic-tumors-in-children
#24
JOURNAL ARTICLE
Aihua Zhang, Shiwu Zhang
PURPOSE: Vasculogenic mimicry (VM) is present in a variety of malignant tumors, and is related to the degree of malignancy. Neuroblastoma (NB) can induce the expression of fetal hemoglobin (HB-F). The purpose of this study was to investigate the clinicopathological significance of the number of VMs and tumor cell expression of HB-F in children with peripheral neuroblastic tumors (pNTs). MATERIALS AND METHODS: We collected tissue samples and clinical data from 101 children with pNTs; prepared serial sections of tissue wax blocks for hematoxylin and eosin staining, CD31/periodic acid-Schiff double staining, and HB-F immunohistochemical staining; and analyzed the experimental results...
2023: American Journal of Translational Research
https://read.qxmd.com/read/37452947/brain-and-spinal-cord-tumors-of-embryonic-origin
#25
JOURNAL ARTICLE
Marios Lampros, George A Alexiou
Embryonal tumors (ETs) of the central nervous system (CNS) comprise a large heterogeneous group of highly malignant tumors that predominantly affect children and adolescents. Currently, the neoplasms classified as ET are the medulloblastoma (MB), embryonal tumors with multilayered rosettes (ETMR), medulloepithelioma (ME), CNS neuroblastoma (NB), CNS ganglioneuroblastoma (GNB), atypical teratoid/rhabdoid tumors (AT/RT), and CNS embryonal tumors with rhabdoid features. All these tumors are classified as malignant-grade IV neoplasms, and the prognosis of patients with these neoplasms is very poor...
2023: Advances in Experimental Medicine and Biology
https://read.qxmd.com/read/37452940/embryonal-tumors-of-the-central-nervous-system-with-multilayered-rosettes-and-atypical-teratoid-rhabdoid-tumors
#26
JOURNAL ARTICLE
Margarita Kamenova, Radka Kaneva, Kamelia Genova, Nikolay Gabrovsky
The 2016 WHO classification of tumors of the central nervous system affected importantly the group of CNS embryonal tumors. Molecular analysis on methylome, genome, and transcriptome levels allowed better classification, identification of specific molecular hallmarks of the different subtypes of CNS embryonal tumors, and their more precise diagnosis. Routine application of appropriate molecular testing and standardized reporting are of pivotal importance for adequate prognosis and treatment, but also for epidemiology studies and search for efficient targeted therapies...
2023: Advances in Experimental Medicine and Biology
https://read.qxmd.com/read/37452211/correlations-between-contrast-enhanced-ct-measured-extracellular-volume-fraction-histopathological-features-and-mycn-amplification-status-in-abdominal-neuroblastoma-a-retrospective-study
#27
JOURNAL ARTICLE
Haoru Wang, Hao Ding, Mingye Xie, Li Zhang, Ting Li, Jinjie Qin, Xin Chen, Ling He
PURPOSE: To retrospectively investigate the correlations between contrast-enhanced CT (CECT)-measured extracellular volume fraction (fECV) and histopathological features, as well as MYCN amplification status, in abdominal neuroblastoma. MATERIALS AND METHODS: One hundred and forty-one patients with abdominal neuroblastoma who underwent CECT scanning were retrospectively enrolled. Calculation of fECV involved the measurement of CT values within regions of interest located within the neuroblastoma and aorta on both non-contrast-enhanced CT and equilibrium CECT...
July 14, 2023: Abdominal Radiology
https://read.qxmd.com/read/37342847/computer-assisted-rescue-of-the-inferior-mesenteric-artery-in-a-child-with-a-giant-ganglioneuroblastoma-a-case-report
#28
Wen-Li Xiu, Jie Liu, Jing-Li Zhang, Nan Su, Feng-Jiao Wang, Xi-Wei Hao, Fei-Fei Wang, Qian Dong
BACKGROUND: Ganglioneuroblastoma (GNB) is a peripheral neuroblastoma (NB) with malignant degree between highly malignant NB and benign ganglioma (GN). Pathology is the gold standard of diagnosis. Although GNB is not uncommon in children, biopsy alone may lead to an inaccurate diagnosis, especially for giant tumors. However, surgical resection may be associated with significant complications. Here, we report a case of computer-assisted surgical resection of a giant GNB in a child and successful rescue of the inferior mesenteric artery...
May 27, 2023: World Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/37331966/gastric-ganglioneuroblastoma-in-an-elderly-man-a-case-report-and-literature-review
#29
JOURNAL ARTICLE
Xuetong Jiang, Jianqiang Wu, Feng Su, Hailong Huang, Yang Ding, Xinqiang Zhu
Background . Ganglioneuroblastoma is a borderline tumor of sympathetic origin that is considered a childhood disease, with the majority of patients occurring in children less than five years old and few patients occurring in adults. There are no treatment guidelines for adult ganglioneuroblastoma. Here, we report a rare patient of adult gastric ganglioneuroblastoma that was completely resected by a laparoscopic approach. Case presentation . A 73-year-old man presented with dull pain in the upper abdomen along with abdominal distension for one month...
June 18, 2023: International Journal of Surgical Pathology
https://read.qxmd.com/read/37243318/ganglioneuroblastoma-intermixed-clinicopathological-implications-of-diagnosis-at-presentation-and-genomic-correlations
#30
JOURNAL ARTICLE
Behtash G Nezami, Shakeel Modak, Fiorella Iglesias Cardenas, Judy Sarungbam, Sahussapont J Sirintrapun, Anuradha Gopalan, Yingbei Chen, Hikmat Al-Ahmadie, Samson W Fine, Victor E Reuter, Satish K Tickoo
BACKGROUND: Ganglioneuroblastoma intermixed (GNBI) is classified as "favorable" histology by International Neuroblastoma Pathology Classification system. However, the International Neuroblastoma Risk Group (INRG) stratifies patients using wider clinicopathological and cytogenetic/molecular parameters. While the diagnosis of GNBI is typically made on resected tumor, it may sometimes be rendered on initial biopsy. We studied GNBI noted at diagnosis to evaluate its correlation with INRG staging and other clinicopathological and molecular features...
August 2023: Pediatric Blood & Cancer
https://read.qxmd.com/read/37226234/identification-and-validation-of-radiomic-features-from-computed-tomography-for-preoperative-classification-of-neuroblastic-tumors-in-children
#31
JOURNAL ARTICLE
Lian Zhao, Liting Shi, Shun-Gen Huang, Tian-Na Cai, Wan-Liang Guo, Xin Gao, Jian Wang
BACKGROUND: To identify radiomic features that can predict the pathological type of neuroblastic tumor in children. METHODS: Data on neuroblastic tumors in 104 children were retrospectively analyzed. There were 14 cases of ganglioneuroma, 24 cases of ganglioneuroblastoma, and 65 cases of neuroblastoma. Stratified sampling was used to randomly allocate the cases into the training and validation sets in a ratio of 3:1. The maximum relevance-minimum redundancy algorithm was used to identify the top 10 of two clinical features and 851 radiomic features in portal venous-phase contrast-enhanced computed tomography images...
May 24, 2023: BMC Pediatrics
https://read.qxmd.com/read/37150742/outcomes-and-histological-variations-of-neuroblastoma-and-ganglioneuroblastoma-with-paraneoplastic-syndromes
#32
JOURNAL ARTICLE
Alexander S Mina, Gloria N Nashed, Andrew M Hermina, Suzanne M Schauwecker, Hannah M Phelps, Daniel J Benedetti, Hernan Correa, Harold N Lovvorn
BACKGROUND: Neuroblastomas are the most common extracranial solid malignancy in children with variable manifestations and complications depending on the presence of paraneoplastic syndromes. MATERIALS AND METHODS: We performed a single institution retrospective cohort study of all patients less than 18 years old diagnosed with neuroblastoma or ganglioneuroblastoma between January 2002 and July 2022. Patients were identified through the pathology and cancer registry and cross-referenced with pediatric records...
May 7, 2023: American Surgeon
https://read.qxmd.com/read/37086056/an-infantile-pineal-embryonal-tumor-showing-pathological-features-of-a-cns-ganglioneuroblastoma-and-the-methylation-profiling-of-an-atypical-teratoid-rhabdoid-tumor-and-smarca4-mutation
#33
JOURNAL ARTICLE
Kohei Fukuoka, Atsuko Nakazawa, Junko Hirato, Sumihito Nobusawa, Toshikazu Itabashi, Yuki Arakawa, Makiko Mori, Yuko Matsushita, Satoko Honda, Yutaka Tanami, Koichi Ichimura, Jun Kurihara, Katsuyoshi Koh
No abstract text is available yet for this article.
April 22, 2023: Journal of Neuropathology and Experimental Neurology
https://read.qxmd.com/read/37077068/extra-adrenal-peripheral-neuroblastic-tumors-a-clinicopathological-study-of-18-cases
#34
JOURNAL ARTICLE
Sunitha Shankaralingappa, Sanjiban Patra, Amisha Gami, Priti Trivedi, Akshay Kumar Chalaliya
BACKGROUND: Peripheral neuroblastic tumors arise from the sympathoadrenal lineage of the neural crest. They have been classified according to the International Neuroblastoma Pathology Committee (INPC) into Four categories according to International Neuroblastoma Pathology Committee (INPC): a) Neuroblastoma (NB) b) Ganglioneuroblastoma (GNB), nodular c) Ganglioneuroblastoma, intermixed, and d) Ganglioneuroma (GN). Because of the rarity of extra-adrenal peripheral neuroblastic tumors, limited information is available regarding the chemotherapy of NB and GNB...
2023: Indian Journal of Pathology & Microbiology
https://read.qxmd.com/read/37056946/erratum-neuroblastic-tumors-of-the-adrenal-gland-in-elderly-patients-a-case-report-and-review-of-the-literature
#35
(no author information available yet)
[This corrects the article DOI: 10.3389/fped.2022.869518.].
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/37035169/clinical-value-of-18-f-fdg-pet-ct-to-predict-mycn-gene-chromosome-1p36-and-11q-status-in-pediatric-neuroblastoma-and-ganglioneuroblastoma
#36
JOURNAL ARTICLE
Jiazhong Ren, Zheng Fu, Yaqing Zhao
OBJECTIVE: To explore the value of 18 F-2-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET)/computed tomography(CT) in MYCN gene and chromosome 1p36 and 11 statuses in newly diagnosed pediatric NB(neuroblastoma) and GNB(ganglioneuroblastoma). METHODS: We retrospectively analyzed newly diagnosed patients with 48 NB and 12 with GNB in our hospital. The data obtained from the clinical medical records included age, sex, pathologic type, and laboratory parameters such as lactate dehydrogenase (LDH), neuron-specific enolase (NSE) and the status of MYCN gene and chromosome 1p36 and 11q...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37019145/five-years-follow-up-of-opsoclonus-myoclonus-ataxia-syndrome-associated-neurogenic-tumors-in-children
#37
JOURNAL ARTICLE
Elif Habibe Aktekin, Hasan Özkan Gezer, Nalan Yazıcı, İlknur Erol, Ayşe Erbay, Faik Sarıalioğlu
AIM:  Opsoclonus-myoclonus-ataxia syndrome (OMAS) is a rare autoimmune disorder. Approximately half of the cases are associated with neuroblastoma in children. This study's aim is to review management of our cases with OMAS-associated neuroblastoma for treatment approach as well as long-term follow-up. METHODS:  Age at onset of symptoms and tumor diagnosis, tumor location, histopathology, stage, chemotherapy, OMAS protocol, surgery, and follow-up period were evaluated retrospectively in six patients between 2007 and 2022...
April 5, 2023: Neuropediatrics
https://read.qxmd.com/read/36892608/whole-tumor-radiomics-analysis-of-t2-weighted-imaging-in-differentiating-neuroblastoma-from-ganglioneuroblastoma-ganglioneuroma-in-children-an-exploratory-study
#38
JOURNAL ARTICLE
Haoru Wang, Xin Chen, Wenqing Yu, Mingye Xie, Li Zhang, Hao Ding, Ting Li, Jinjie Qin, Ling He
PURPOSE: To examine the potential of whole-tumor radiomics analysis of T2-weighted imaging (T2WI) in differentiating neuroblastoma (NB) from ganglioneuroblastoma/ganglioneuroma (GNB/GN) in children. MATERIALS AND METHODS: This study included 102 children with peripheral neuroblastic tumors, comprising 47 NB patients and 55 GNB/GN patients, which were randomly divided into a training group (n = 72) and a test group (n = 30). Radiomics features were extracted from T2WI images, and feature dimensionality reduction was applied...
March 9, 2023: Abdominal Radiology
https://read.qxmd.com/read/36844643/pathological-and-clinical-outcomes-of-adrenalectomy-a-multi-center-experience-in-saudi-arabia
#39
JOURNAL ARTICLE
Raed A Azhar, Omar Buksh, Musab M Alghamdi, Waseem Tayeb, Mohnna S Subahi, Abdulaziz M Bakhsh, Sultan S Alkhateeb
OBJECTIVE: To determine the nature of adrenal pathology in patients undergoing adrenalectomy in Saudi Arabia over the last decade and compare it with the literature. We compared perioperative outcomes between minimally invasive adrenalectomy (MIA) and open adrenalectomy (OA). METHODS: This retrospective study included patients who underwent adrenalectomy at five tertiary care centers in Saudi Arabia from 2010 to 2020. We collected patients' baseline and perioperative characteristics and detailed hormonal evaluation of adrenal masses...
March 2023: Saudi Journal of Biological Sciences
https://read.qxmd.com/read/36842043/paediatric-metastatic-ganglioneuroblastoma-on-68ga-dota-noc-pet-ct
#40
JOURNAL ARTICLE
Sharjeel Usmani, Sanad Al-Mohtab, Farah Luai Albader, Fareeda Al Kandari
68Ga-DOTA NOC PET-CT imaging has been shown to have high accuracy for the evaluation of neuroendocrine tumours. We report a case of a 3-year-old boy who presented with a right paravertebral soft tissue mass. Biopsy showed ganglioneuroblastoma. The patient was referred for 68Ga-DOTA NOC for staging. 68Ga-DOTA NOC PET/CT images showed somatostatin-avid large right paravertebral soft tissue mass representing the primary lesion, along with increased radiotracer localization at multiple metastatic lytic bone lesions in the axial and appendicular skeleton...
January 2023: JPMA. the Journal of the Pakistan Medical Association
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