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ganglioneuroblastoma

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https://www.readbyqxmd.com/read/29771688/plexiform-atypical-spitz-tumor-with-rosette-like-giant-cells-a-histologic-and-immunohistochemical-study-on-a-case-suggesting-ganglioneuroblastic-differentiation-review-of-the-literature-and-considerations-on-histogenesis
#1
Elena Castelli, Elisabetta Orlando, Giuseppe Pistone, Maria R Bongiorno
Spitz nevi, atypical Spitz tumors and Spitzoid melanoma, the three clinicopathologic forms that constitute the spectrum of the Spitz-type melanocytic lesions, share a histologic picture characterized by large spindle and/or epithelioid ganglion-like cells, with various admixtures of multinucleate bizarre cells. This remarkable cytology has always been interpreted as an unusual, as well as unexplained form of atypia. We report a case of atypical Spitz tumor with Homer Wright-like rosettes, a feature characteristic of ganglioneuroblastic proliferation...
May 16, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29720264/usefulness-of-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-for-detection-of-a-neuroblastic-nodule-in-a-ganglioneuroblastoma-a-case-report
#2
Yuka Takeda, Hideki Sano, Asuka Kawano, Kazuhiro Mochizuki, Nobuhisa Takahashi, Shogo Kobayashi, Yoshihiro Ohara, Kazuhiro Tasaki, Mitusuaki Hosoya, Atsushi Kikuta
BACKGROUND: Ganglioneuroblastoma, nodular is defined as a composite tumor of biologically distinct clones. The peripheral neuroblastic tumors in this category are characterized by the presence of grossly visible neuroblastoma nodules coexisting with ganglioneuroblastoma, intermixed, or with ganglioneuroma. Making a correct diagnosis of ganglioneuroblastoma, nodular is often difficult by biopsy or partial tumor resection, because the neuroblastic nodule could be hidden and not sampled for pathological examination...
May 3, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29704303/atypical-presentations-associated-with-non-polyalanine-repeat-phox2b-mutations
#3
Umakanth Katwa, Alissa M D'Gama, Anita E Qualls, Lucas M Donovan, Jody Heffernan, Jiahai Shi, Pankaj B Agrawal
Congenital central hypoventilation syndrome (CCHS) is a disorder of ventilatory control and autonomic dysregulation that can be caused by mutations in the paired-like homeobox 2B (PHOX2B) gene. The majority of CCHS cases are caused by polyalanine repeat mutations (PARMs) in PHOX2B; however, in rare cases, non-polyalanine repeat mutations (NPARMs) have been identified. Here, we report two patients with NPARMs in PHOX2B. Patient 1 has a mild CCHS phenotype seen only on polysomnogram, which was performed for desaturations and stridor following a bronchiolitis episode, and characterized by night-time hypoventilation and a history of ganglioneuroblastoma...
April 28, 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29699729/pacap-and-vip-regulate-hypoxia-inducible-factors-in-neuroblastoma-cells-exposed-to-hypoxia
#4
Grazia Maugeri, Agata Grazia D'Amico, Daniela Maria Rasà, Salvatore Saccone, Concetta Federico, Sebastiano Cavallaro, Velia D'Agata
Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are two related peptides acting as neurotransmitters/neuromodulators in central and peripheral nervous system. They are also involved in cancer showing a controversial role. Particulary, they are implicated in neuroblastoma differentiation (NB). This pediatric tumor can evolve to a malignant metastatic disease or spontaneously regress towards a benign form, known as ganglioneuroblastoma/ganglioneuroma. A negative hallmark of neoplasia progression is represented by hypoxic microenvironment...
April 17, 2018: Neuropeptides
https://www.readbyqxmd.com/read/29696040/adrenal-ganglioneuroblastoma-in-an-adult-a-rare-case-report
#5
Zahra Heidari, Mahmoud Ali Kaykhaei, Mahdi Jahantigh, Vahid Sheikhi
Ganglioneuroblastoma is a primary malignant tumor of the sympathetic nervous system. It usually occurs in children and is extremely rare in adults. Here, we report a case of an adrenal ganglioneuroblastoma in a 38-year-old man. The adrenal incidentaloma was surgically removed and pathologically diagnosed as a ganglioneuroblastoma. The characteristics were described, because it is an unusual tumor based on the published reports in adults. To the best of our knowledge, fewer than 50 cases of ganglioneuroblastoma and 19 cases of adrenal ganglioneuroblastoma, including this case, are reported in the literature...
January 2018: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29692663/uncommon-reasons-of-the-digestive-tract-related-paraneoplastic-syndromes-in-children-with-neuroblastic-tumors-three-case-reports
#6
Elżbieta Czkwianianc, Beata Zalewska-Szewczyk, Józef Kobos, Anna Socha-Banasiak, Szymon Janczar, Sylwia Prymus-Kasińska, Joanna Kazanek-Zasada, Wojciech Młynarski
Aim of the study: presentation of the uncommon paraneoplastic syndromes related to the gastrointestinal tract that may occur in children with neuroblastic tumors and their impact on the disease course. Material and methods: Retrospective analysis of three cases of patients mainly with digestive tract-related symptoms, who were originally admitted to the gastroenterology department from 2013 to 2016 and were finally diagnosed with neuroblastic tumors. Results: The clinical data analysis showed that the symptoms from gastrointestinal tract were dominant in analyzed subjects...
2018: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/29673989/persisting-inequalities-in-survival-patterns-of-childhood-neuroblastoma-in-southern-and-eastern-europe-and-the-effect-of-socio-economic-development-compared-with-those-of-the-us
#7
Paraskevi Panagopoulou, Marios K Georgakis, Margarita Baka, Maria Moschovi, Vassilios Papadakis, Sophia Polychronopoulou, Maria Kourti, Emmanuel Hatzipantelis, Eftichia Stiakaki, Helen Dana, Athanasios Tragiannidis, Evdoxia Bouka, Luis Antunes, Joana Bastos, Daniela Coza, Anna Demetriou, Domenic Agius, Sultan Eser, Raluca Gheorghiu, Mario Šekerija, Maciej Trojanowski, Tina Žagar, Anna Zborovskaya, Anton Ryzhov, Nick Dessypris, Daniel Morgenstern, Eleni Th Petridou
AIM: Neuroblastoma outcomes vary with disease characteristics, healthcare delivery and socio-economic indicators. We assessed survival patterns and prognostic factors for patients with neuroblastoma in 11 Southern and Eastern European (SEE) countries versus those in the US, including-for the first time-the Nationwide Registry for Childhood Hematological Malignancies and Solid Tumours (NARECHEM-ST)/Greece. METHODS: Overall survival (OS) was calculated in 13 collaborating SEE childhood cancer registries (1829 cases, ∼1990-2016) and Surveillance, Epidemiology, and End Results (SEER), US (3072 cases, 1990-2012); Kaplan-Meier curves were used along with multivariable Cox regression models assessing the effect of age, gender, primary tumour site, histology, Human Development Index (HDI) and place of residence (urban/rural) on survival...
April 16, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29619527/neuroblastic-tumors-in-young-adults-as-a-sequela-of-malignant-neuroblastoma-report-of-two-cases
#8
Takuya Adachi, Minato Yokoyama, Yasuhisa Fujii, Yuko Kinowaki, Susumu Kirimura, Kazunori Kubota, Yukihisa Saida, Ukihide Tateishi
Neuroblastoma, ganglioneuroblastoma, and ganglioneuroma share the same histological spectrum which originates from neural crest cells. We present herein two young adult patients with neuroblastic tumors with lymph node metastases. Both the patients were diagnosed incidentally as having retroperitoneal masses, which showed little or no immature cells despite coexistence of lymph node involvement. The tumors were considered to represent spontaneous regression of malignant neuroblastoma. Radiologists should consider the possibility of spontaneous regression of neuroblastic tumors, when poorly enhanced multi-component masses at the retroperitoneum with lymph node involvement are visualized...
April 4, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29561407/primary-cervical-ganglioneuroblastoma-a-case-report
#9
Dan Lu, Jun Liu, Yuan Chen, Fei Chen, Hui Yang
RATIONALE: Ganglioneuroblastoma is usually located in the adrenal gland, retroperitoneal ganglia, or posterior mediastinum, but rarely occurs in the parapharyngeal space. PATIENT CONCERNS: A 4-year-old girl presented with complaint of progressive inspiratory dyspnea and dysphagia, accompanying left-side Horner's syndrome. DIAGNOSE: Computed tomography (CT) scan revealed a giant mass with irregular low density in left oropharyngeal and posterior pharyngeal wall...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29526867/cervical-ganglioneuroblastoma-in-a-new-born-japanese-black-calf
#10
Chun-Ho Park, Nozomi Shiwa, Kazunori Kimitsuki, Takehito Kakizaki, Daisaku Watanabe
This case report describes a congenital ganglioneuroblastoma in a 38-day-old male Japanese Black calf. The cervical multinodular mass was present at birth and grew rapidly. The cut surface was pale gray-to-yellow and had a gelatinous appearance. Hemorrhagic cysts of various sizes were observed in the nodule. Histologically, the mass contained clusters of neuroblastic cells, ganglionic cells, and Schwann-like cells. Immunohistochemically, the ganglionic cells showed strong positivity for neuron-specific enolase, neurofilament, synaptophysin, and chromogranin A, whereas the Schwann-like cells strongly expressed S-100, glial fibrillary acidic protein, and vimentin...
March 9, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29514842/enhanced-intratumoral-delivery-of-sn38-as-a-tocopherol-oxyacetate-prodrug-using-nanoparticles-in-a-neuroblastoma-xenograft-model
#11
Ferro Nguyen, Ivan Alferiev, Peng Guan, David T Guerrero, Venkatadri Kolla, Ganesh S Moorthy, Michael Chorny, Garrett M Brodeur
Purpose: Currently, <50% of high-risk pediatric solid tumors like neuroblastoma can be cured, and many survivors experience serious or life-threatening toxicities, so more effective, less toxic therapy is needed. One approach is to target drugs to tumors using nanoparticles, which take advantage of the enhanced permeability of tumor vasculature. Experimental Design: SN38, the active metabolite of irinotecan (CPT-11), is a potent therapeutic agent that is readily encapsulated in polymeric nanoparticles. Tocopherol oxyacetate (TOA) is a hydrophobic mitocan that was linked to SN38 to significantly increase hydrophobicity and enhance nanoparticle retention...
March 7, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29506484/lymphnode-tuberculosis-in-a-4-year-old-boy-with-relapsed-ganglioneuroblastoma-a-case-report
#12
Karoline van de Loo, Stefan Balzer, Colin R MacKenzie, Thomas M Boemers, Monika Ortmann, Jörg Schaper, Arndt Borkhardt, Hans-Jürgen Laws, Michaela Kuhlen
BACKGROUND: Mycobacterium tuberculosis (M. tuberculosis) disease is a generally well-known problem among immunocompromised adults and children. In pediatric oncology, only few cases of M. tuberculosis disease are reported so far. CASE PRESENTATION: We report a case of concomitant lymphnode tuberculosis in a 4-year-old German boy with relapsed ganglioneuroblastoma. 18 months after the initial diagnosis, relapse with new paravertebral lesions and new lesions in the left lower lobe of the lung and in the perihilar lymphnodes suspicious of metastases of the ganglioneuroblastoma were detected...
March 5, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29496580/pediatric-supratentorial-ganglioneuroblastoma-case-report-and-review-of-literature
#13
Farhan A Mirza, Brian Synder, Vanessa D Smith, Raul A Vasquez
BACKGROUND: Pediatric cerebral ganglioneuroblastoma is an exceedingly rare tumor. CASE DESCRIPTION: We describe the case of a 4-year-old boy with sudden mental status decline who was found to have a large intracranial lesion with intraventricular extension. CONCLUSION: Management of the case and pathologic findings are discussed, along with a review of the literature on this rare entity.
May 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29390424/adult-hippocampal-ganglioneuroblastoma-case-report-and-literature-review
#14
Pei-Sen Yao, Guo-Rong Chen, Huang-Cheng Shang-Guan, Qing-Song Lin, Xing-Fu Wang, Shu-Fa Zheng, De-Zhi Kang
RATIONALE: Intracranial ganglioneuroblastoma represents a rare subtype of primitive neuroectodermal tumor. Here, we report a hippocampal ganglioneuroblastoma and a literature review of cerebral anglioneuroblastoma is carried out. PATIENT CONCERNS: We report a 16-year-old male patient presenting with absence seizure and high-infiltration hippocampal ganglioneuroblastoma. INTERVENTIONS: Magnetic resonance imaging (MRI) indicates a space-occupying lesion with a well-defined margin in the right temporal lobe and hippocampus...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29369484/characteristics-and-management-of-ganglioneuroma-and-ganglioneuroblastoma-intermixed-in-children-and-adolescents
#15
Natasha Alexander, Katie Sullivan, Furqan Shaikh, Meredith S Irwin
BACKGROUND: Ganglioneuromas (GNs) usually demonstrate favorable histological and clinical features. Surgery is often performed due to clinical symptoms and/or theoretical concerns that GN may transform into neuroblastoma (NB); however, several studies have identified significant GN-surgical morbidities. OBJECTIVES: We compared the natural history, biological and clinical features of GN and ganglioneuroblastoma-intermixed (GNB-I) managed by surgery or observation to inform management and surveillance...
January 25, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29260287/change-in-liver-spleen-and-bone-marrow-magnetic-resonance-imaging-signal-intensity-over-time-in-children-with-solid-abdominal-tumors
#16
Michael Sirignano, Jonathan R Dillman, Brian D Weiss, Charles T Quinn, Bin Zhang, Weizhe Su, Andrew T Trout
BACKGROUND: Reticuloendothelial system MRI signal hypointensity is common in pediatric oncology patients with solid abdominal tumors. OBJECTIVE: To assess changes in liver, spleen and bone marrow T2-weighted MRI signal intensity over time and their relationship to blood transfusion history in children with solid abdominal tumors. MATERIALS AND METHODS: In this retrospective study we measured liver, spleen and bone marrow signal intensity on axial T2-weighted MR images obtained December 2009 through February 2016 in children with hepatoblastoma, neuroblastoma, ganglioneuroblastoma and Wilms tumor...
March 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29225862/hitherto-unseen-survival-in-an-alk-positive-patient-with-advanced-stage-adult-ganglioneuroblastoma-treated-with-personalized-medicine
#17
Signe Risum, Ulrich Knigge, Seppo W Langer
Survival of stage 4 ganglioneuroblastoma (GNB) patients is poor; no reports exist of patients surviving up to 5 years (1, 2). We report the clinical and therapeutic course of a patient with stage 4 GNB surviving beyond expectations due to a multimodal treatment approach incorporating new technologies in cancer diagnostic and treatment.
December 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29103425/cancer-and-autoimmunity-paraneoplastic-neurological-disorders-associated-with-neuroblastic-tumors
#18
Wendy G Mitchell, Franz Blaes
Cancer and autoimmunity come together in paraneoplastic syndromes (PNS), which reflect the remote, not direct, effects of cancer. In the pediatric population, a variety of PNS have been described, but the most common of these rare disorders are instigated by neuroblastic tumors, such as neuroblastoma, ganglioneuroblastoma, and ganglioneuroma. The main pediatric-onset neurological PNS are ROHHAD syndrome, anti-ANNA1 (anti-Hu), and opsoclonus-myoclonus syndrome. They manifest distinctive neurological features, which aid the diagnosis, though under-recognition still poses serious challenges and risks...
August 2017: Seminars in Pediatric Neurology
https://www.readbyqxmd.com/read/28994241/legumain-correlates-with-neuroblastoma-differentiation-and-can-be-used-in-prodrug-design
#19
Min Zhang, Zhiteng Jiang, Sheng Chen, Zhixiang Wu, Kai Chen, Yeming Wu
Neuroblastoma (NB) is a highly malignant solid tumor in children. The cysteine endopeptidase legumain is expressed in adult solid tumors, but its expression in NB has not been examined. In this study, we assayed legumain expression in two NB cell lines and in microarrays of tumor tissues collected from 46 children with undifferentiated NB, differentiated NB, and ganglioneuroblastoma. Correlation analyses showed that legumain was expressed in all NB cell lines tested and that expression correlated with the degree of tumor differentiation...
February 2018: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28986989/utility-of-phox2b-immunohistochemical-stain-in-neural-crest-tumours-and-non-neural-crest-tumours-in-paediatric-patients
#20
Mikako Warren, Ryosuke Matsuno, Henry Tran, Hiroyuki Shimada
AIMS: This study evaluated the utility of Phox2b in paediatric tumours. Previously, tyrosine hydroxylase (TH) was the most widely utilised sympathoadrenal marker specific for neural crest tumours with neuronal/neuroendocrine differentiation. However, its sensitivity is insufficient. Recently Phox2b has emerged as another specific marker for this entity. METHODS AND RESULTS: Phox2b immunohistochemistry (IHC) was performed on 159 paediatric tumours, including (group 1) 65 neural crest tumours with neuronal differentiation [peripheral neuroblastic tumours (pNT)]: 15 neuroblastoma undifferentiated (NB-UD), 10 NB poorly differentiated (NB-PD), 10 NB differentiating (NB-D), 10 ganglioneuroblastoma intermixed (GNBi), 10 GNB nodular (GNBn) and 10 ganglioneuroma (GN); (group 2) 23 neural crest tumours with neuroendocrine differentiation [pheochromocytoma/paraganglioma (PCC/PG)]; (group 3) 27 other neural crest tumours including one composite rhabdomyosarcoma/neuroblastoma; and (group 4) 44 non-neural crest tumours...
March 2018: Histopathology
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