keyword
https://read.qxmd.com/read/36960114/the-role-of-triple-rule-out-ct-in-an-indian-emergency-setting
#21
JOURNAL ARTICLE
Navaneeth Pattereth, Shafneed Chaliyadan, Roshan Mathew, Sanjeev Kumar, Chandan J Das, Praveen Aggarwal, Nayer Jamshed
BACKGROUND: Emergency physicians are acutely aware of the consequences of missing fatal diagnoses for acute non-traumatic chest pain and subjecting patients to over-testing. In the large arsenal of tests that are available to us, a triple rule-out computed tomography (TRO-CT) Angiography is often less pursued, due to concerns about their efficacy and safety or because of nescience. We aim to find the yield of the test in an Indian emergency setting and impart some knowledge about it along the way...
March 2023: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/36948447/back-to-the-future-of-viruses-a-case-of-triple-coinfection-caused-by-rsv-hcov-oc43-and-rhinovirus
#22
Benjamin Davido, Karim Jaffal, Elyanne Gault, Stephane Bourlet, Sebastien Beaune
We present the case of an 81-year-old man, who was immunocompetent, who was admitted to the hospital with symptoms of fever and dyspnea, suspected to be caused by Covid-19. Further examination revealed a triple coinfection, as determined by multiplex PCR testing, caused by RSV, hCoV-OC43, and rhinovirus. Upon auscultation, diffuse wheezing without crackles was detected. After ruling out the possibility of acute heart failure with pulmonary edema, the patient was treated with nebulization of terbutaline for a period of 72 hours...
March 20, 2023: International Journal of Infectious Diseases: IJID
https://read.qxmd.com/read/36832249/diagnosis-of-an-acute-anterior-wall-infarction-in-dual-energy-ct
#23
JOURNAL ARTICLE
Aynur Gökduman, Ibrahim Yel, Thomas J Vogl, Mirela Dimitrova, Leon D Grünewald, Vitali Koch, Leona S Alizadeh, Andreas S Brendlin, Ahmed E Othman, Simon S Martin, Tommaso D'Angelo, Alfredo Blandino, Silvio Mazziotti, Christian Booz
Due to its high morbidity and mortality, myocardial infarction is the leading cause of death worldwide. Against this background, rapid diagnosis is of immense importance. Especially in case of an atypical course, the correct diagnosis may be delayed and thus lead to increased mortality rates. In this report, we present a complex case of acute coronary syndrome. A triple-rule-out CT examination was performed in dual-energy CT (DECT) mode. While pulmonary artery embolism and aortic dissection could be ruled out with conventional CT series, the presence of anterior wall infarction was only detectable on DECT reconstructions...
February 17, 2023: Diagnostics
https://read.qxmd.com/read/36792689/uncovering-hidden-network-architecture-from-spiking-activities-using-an-exact-statistical-input-output-relation-of-neurons
#24
JOURNAL ARTICLE
Safura Rashid Shomali, Seyyed Nader Rasuli, Majid Nili Ahmadabadi, Hideaki Shimazaki
Identifying network architecture from observed neural activities is crucial in neuroscience studies. A key requirement is knowledge of the statistical input-output relation of single neurons in vivo. By utilizing an exact analytical solution of the spike-timing for leaky integrate-and-fire neurons under noisy inputs balanced near the threshold, we construct a framework that links synaptic type, strength, and spiking nonlinearity with the statistics of neuronal population activity. The framework explains structured pairwise and higher-order interactions of neurons receiving common inputs under different architectures...
February 15, 2023: Communications Biology
https://read.qxmd.com/read/36750257/fch-pet-ct-in-primary-hyperparathyroidism-with-discordant-negative-mibi-scintigraphy-and-ultrasonography
#25
JOURNAL ARTICLE
Eugenie Koumakis, Mathieu Gauthé, Alessandro Martinino, Rémy Sindayigaya, Thierry Delbot, Myriam Wartski, Jérôme Clerc, Christian Roux, Didier Borderie, Beatrix Cochand-Priollet, Catherine Cormier, Sébastien Gaujoux
CONTEXT: The contribution of [18F]F-fluorocholine (FCH)PET/CT in normocalcemic primary hyperparathyroidism (nPHPT) remains unknown. OBJECTIVE: To evaluate the sensitivity and specificity of FCH-PET/CT in a cohort of osteoporotic nPHPT patients with discordant or negative MIBI scintigraphy and ultrasonography who all underwent parathyroidectomy (PTX). DESIGN: Longitudinal retrospective cohort study in patients referred for osteoporosis with mild biological primary hyperparathyroidism...
February 8, 2023: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/36731730/causal-knowledge-graph-construction-and-evaluation-for-clinical-decision-support-of-diabetic-nephropathy
#26
JOURNAL ARTICLE
Kewei Lyu, Yu Tian, Yong Shang, Tianshu Zhou, Ziyue Yang, Qianghua Liu, Xi Yao, Ping Zhang, Jianghua Chen, Jingsong Li
BACKGROUND: Many important clinical decisions require causal knowledge (CK) to take action. Although many causal knowledge bases for medicine have been constructed, a comprehensive evaluation based on real-world data and methods for handling potential knowledge noise are still lacking. OBJECTIVE: The objectives of our study are three-fold: (1) propose a framework for the construction of a large-scale and high-quality causal knowledge graph (CKG); (2) design the methods for knowledge noise reduction to improve the quality of the CKG; (3) evaluate the knowledge completeness and accuracy of the CKG using real-world data...
January 30, 2023: Journal of Biomedical Informatics
https://read.qxmd.com/read/36692854/computational-study-for-chemoselective-difunctionalization-of-unactivated-alkenes-with-radical-mediated-remote-functional-group-migration
#27
JOURNAL ARTICLE
Ferruh Lafzi, Selçuk Eşsiz
A computational study of the radical-mediated chemoselective difunctionalization of the tertiary alcohol substituted aliphatic alkenes is carried out employing density functional theory (DFT) and high-level coupled-cluster methods, such as coupled-cluster singles and doubles with perturbative triples [DLPNO-CCSD(T)]. Our results indicate that the cyclic vinyl radical plays an important role in the progression of the reactions. Our computations demonstrated that the chemoselective difunctionalization of unactivated alkenes with radical-mediated remote functional group migration is suitable for the 5- and 6-exo-dig cyclization, as opposite to 3- and 4-exo-dig cyclization suffering from cyclic intermediate with high energy...
January 24, 2023: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://read.qxmd.com/read/36534035/interaction-of-ch-3-cn-and-ch-3-nc-with-he-potential-energy-surfaces-and-low-energy-scattering
#28
JOURNAL ARTICLE
Malek Ben Khalifa, Paul J Dagdigian, Jérôme Loreau
Several nitrogen-bearing molecules, such as methyl cyanide (or acetonitrile, CH3 CN) and methyl isocyanide (CH3 NC) of interest here, have been observed in various astrophysical environments. The accurate modeling of their abundance requires the calculation of rate coefficients for their collisional excitation with species such as He atoms or H2 molecules at low temperatures. In this work we compute new three-dimensional potential energy surfaces for the CH3 NC-He and CH3 CN-He van der Waals complexes by means of the explicitly correlated coupled cluster approach with single, double and perturbative triple excitation CCSD(T)/F12a in conjunction with the aug-cc-pVTZ basis set...
December 19, 2022: Journal of Physical Chemistry. A
https://read.qxmd.com/read/36481725/quality-evaluation-of-ginkgo-biloba-leaves-based-on-non-targeted-metabolomics-and-representative-ingredient-quantification
#29
JOURNAL ARTICLE
Huifang Gao, Xialin Chen, Yuman Li, Xia Gao, Jiajia Wang, Mengyu Qian, Xiaoyu Tong, Shanli Wang, Yuefei Wang, Jian Feng, Liang Cao, Zhenzhong Wang, Wei Xiao
Ultra-performance liquid chromatography coupled with time-of-flight mass spectrometry (UPLC-Q-TOF-MS/MS) combined with multivariate statistical analysis was applied to the study of plant metabolomics to reveal the factors affecting the content of ginkgo leaf compounds. As a follow-up analysis, the terpene lactones and ginkgolic acids were quantified simultaneously using ultra-performance liquid chromatography coupled with triple quadrupole mass spectrometry (UPLC-QqQ-MS/MS), and subsequently total flavonol glycosides were quantified by high-performance liquid chromatography (HPLC)...
January 1, 2023: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://read.qxmd.com/read/36479470/clearance-of-ctdna-in-triple-negative-and-her2-positive-breast-cancer-patients-during-neoadjuvant-treatment-is-correlated-with-pathologic-complete-response
#30
JOURNAL ARTICLE
Nikaoly Ciriaco, Esther Zamora, Santiago Escrivá-de-Romaní, Ignacio Miranda Gómez, José Jiménez Flores, Cristina Saura, Hillary Sloane, Anna Starus, Johannes Fredebohm, Lucy Georgieva, Graham Speight, Frederick Jones, Santiago Ramón Y Cajal, Martín Espinosa-Bravo, Vicente Peg
BACKGROUND: Although the standard of care is to perform surgery of primary breast cancer (BC) after neoadjuvant chemotherapy (NAC), for certain patients achieving clinical complete response (cCR) and pathologic complete response (pCR), omission of surgical treatment may be an option. Levels of circulating tumor DNA (ctDNA) during and after therapy could identify patients achieving minimal residual disease. In this study, we evaluated whether ctDNA clearance during NAC could be a correlate to effective response in human epidermal growth factor receptor 2 positive (HER2+) and triple-negative (TN) BC patients...
2022: Therapeutic Advances in Medical Oncology
https://read.qxmd.com/read/36397913/plasmodium-falciparum-vivax-and-scrub-typhus-in-a-young-adult-male-surviving-a-triple-strike
#31
Vijay Kota, Ruchita Kabra, Sunil Kumar, Sourya Acharya, Rinkle R Gemnani
Malaria is caused by Plasmodium species and is called a "Rainy season disease". Scrub typhus is a zoonotic disease caused by Orientia tsutsugamushi. Both diseases occurring as co-infection are very rare. If a patient presents with a fever complaint, all the possible causes should be ruled out even if the patient shows infectivity for one of the vector-borne diseases. This case report shows the rare occurrence of the co-infection and its presentation. Early detection and timely management can prevent the patient from various fatal complications...
October 2022: Curēus
https://read.qxmd.com/read/36359488/dedicated-ccta-followed-by-high-pitch-scanning-versus-tro-ct-for-contrast-media-and-radiation-dose-reduction-a-retrospective-study
#32
JOURNAL ARTICLE
Kun Wang, Xiaodong Wang, Shaoqiang Zheng, Cheng Li, Liang Jin, Ming Li
We aimed to compare dedicated coronary computed tomography angiography (CCTA) followed by high-pitch scanning and triple-rule-out computed tomography angiography (TRO-CTA) in terms of radiation dose, contrast media (CM) use, and image quality. Patients with acute chest pain were retrospectively enrolled and assigned to group A ( n = 55; scanned with dedicated CCTA followed by high-pitch scanning) or group B ( n = 45; with TRO-CTA). Patient characteristics, radiation dose, CM use, and quantitative parameters (CT value, image noise, signal-to-noise ratio, contrast-to-noise ratio, and image quality score) of pulmonary arteries (PAs), thoracic aortae (TAs), and coronary arteries (CAs) were compared...
October 31, 2022: Diagnostics
https://read.qxmd.com/read/36324558/price-reductions-in-hearing-aids-and-access-to-audiologists-israel
#33
JOURNAL ARTICLE
Limor Lavie, Tali Bar-Moshe
PROBLEM: Hearing rehabilitation with hearing aids is a complex process which requires professional expertise and the involvement of audiologists or hearing-care specialists. Professional care, however, requires extra resources, making it tempting to rely solely on technology and reduce the role of professional counselling. APPROACH: To reduce the out-of-pocket share for adults needing hearing rehabilitation, in 2011 the Israeli government tripled the subsidy for adult hearing aids by converting 3 years of subsidies into a triennial, enlarged fund...
November 1, 2022: Bulletin of the World Health Organization
https://read.qxmd.com/read/36237227/catastrophic-presentation-of-peripartum-cardiomyopathy-a-case-report-of-a-challenging-diagnosis
#34
Mariana Ribeiro Silva, Gualter Santos Silva, Daniel Caeiro, Ricardo Fontes-Carvalho
BACKGROUND: Peripartum cardiomyopathy (PPCM) usually affects women in the last month of pregnancy or in the first months following delivery and typically presents with signs and symptoms of heart failure (HF), although catastrophic presentations may be the initial manifestation. CASE SUMMARY: A 36-year-old woman reported intense fatigue that began after delivery. Three months following delivery, she suffered a cardiac arrest at home, in shockable rhythm, with a total estimated time of 70 min before return of spontaneous circulation...
October 2022: European Heart Journal. Case Reports
https://read.qxmd.com/read/36160833/triple-rule-out-computed-tomography-angiography-evaluation-of-acute-chest-pain-in-covid-19-patients-in-the-emergency-department
#35
JOURNAL ARTICLE
Suzan Bahadir, Sonay Aydın, Mecit Kantarci, Edhem Unver, Erdal Karavas, Düzgün Can Şenbil
BACKGROUND: The aim of this study was to define clinical evidence supporting that triple rule-out computed tomography angiography (TRO CTA) is a comprehensive and feasible diagnostic tool in patients with novel coronavirus disease 2019 (COVID-19) who were admitted to the emergency department (ED) for acute chest pain. Optimizing diagnostic imaging strategies in COVID-19 related thromboembolic events, will help for rapid and noninvasive diagnoses and results will be effective for patients and healthcare systems in all aspects...
August 28, 2022: World Journal of Radiology
https://read.qxmd.com/read/36104545/improvement-of-dicarboxylic-acid-production-with-methylorubrum-extorquens-by-reduction-of-product-reuptake
#36
JOURNAL ARTICLE
Laura Pöschel, Elisabeth Gehr, Markus Buchhaupt
The methylotrophic bacterium Methylorubrum extorquens AM1 has the potential to become a platform organism for methanol-driven biotechnology. Its ethylmalonyl-CoA pathway (EMCP) is essential during growth on C1 compounds and harbors several CoA-activated dicarboxylic acids. Those acids could serve as precursor molecules for various polymers. In the past, two dicarboxylic acid products, namely mesaconic acid and 2-methylsuccinic acid, were successfully produced with heterologous thioesterase YciA from Escherichia coli, but the yield was reduced by product reuptake...
September 15, 2022: Applied Microbiology and Biotechnology
https://read.qxmd.com/read/36031376/-a-case-of-triple-a-syndrome-with-c-463c-t-mutation-in-the-aaas-gene
#37
JOURNAL ARTICLE
Hiroaki Hirosawa, Hirofumi Konishi, Takamasa Nukui, Tomohiro Hayashi, Nobuhiro Dougu, Yuji Nakatsuji
A 47-year-old woman was admitted to our hospital for scrutiny of limb weakness and orthostatic hypotension that had progressed from childhood. She had been treated for alacrima and esophageal achalasia from childhood. On admission, she had hyperreflexia of upper and lower extremities, distal predominant muscle atrophy in the lower extremities, decreased sensation of the distal extremities, and autonomic neuropathy. Her blood test results ruled out adrenal insufficiency, but Schirmer's test was positive. Given the lacrimation symptoms, esophageal achalasia, and neuropathy, the patient was diagnosed with triple A syndrome in whom a c...
August 26, 2022: Rinshō Shinkeigaku, Clinical Neurology
https://read.qxmd.com/read/35811358/effects-of-medicaid-expansion-on-insurance-coverage-and-health-services-use-among-adults-with-disabilities-newly-eligible-for-medicaid
#38
JOURNAL ARTICLE
Timothy B Creedon, Samuel H Zuvekas, Steven C Hill, Mir M Ali, Chandler McClellan, Judith G Dey
OBJECTIVE: To estimate the effects of Affordable Care Act (ACA) Medicaid expansion on insurance coverage and health services use for adults with disabilities who were newly eligible for Medicaid. DATA SOURCES: 2008-2018 Medical Expenditure Panel Survey data. STUDY DESIGN: We used the Agency for Healthcare Research and Quality (AHRQ) PUBSIM model to identify adults aged 26-64 years with disabilities who were newly Medicaid-eligible in expansion states or would have been eligible in non-expansion states had those states opted to expand...
July 10, 2022: Health Services Research
https://read.qxmd.com/read/35733414/pharmacokinetics-of-extrafine-beclometasone-dipropionate-formoterol-fumarate-glycopyrronium-bromide-in-adolescent-and-adult-patients-with-asthma
#39
JOURNAL ARTICLE
Piotr Kuna, Joanna Jerzynska, Matteo Martini, Andrea Vele, Irene Barneschi, Fabrizia Mariotti, George Georges, Giorgia Ciurlia
The single-inhaler extrafine formulation triple combination beclometasone dipropionate (BDP), formoterol fumarate (FF) plus glycopyrronium bromide (GB) is available for asthma management in adults. Its use in adolescents has not yet been evaluated. This study investigated the pharmacokinetic profile of BDP/FF/GB in adults and adolescents, with the aim of ruling out higher plasma exposure in adolescents compared to adults. In this open-label, non-randomized study, patients with asthma aged 12-17 (adolescents) and 18-64 years (adults) self-administered a single dose of BDP/FF/GB 400/24/50 μg via pressurized metered-dose inhaler (pMDI)...
August 2022: Pharmacology Research & Perspectives
https://read.qxmd.com/read/35606041/filariasis-presenting-as-pancytopenia-in-a-child
#40
JOURNAL ARTICLE
Anusree Krishna Mandal, Jadab Kumar Jana, Soumya Gayen, Abhay Charan Pal
A female child hailing from South Asia, India presented with pallor, multiple petechiae and ecchymosis. Based on the clinical picture and demography, the differentials considered were pancytopenia of nutritional origin, acute leukaemia, autoimmune and infective aetiologies. After ruling these out by respective tests, a literature review was done which revealed the possibility of filariasis especially in a patient with eosinophilia which was present in our case. A repeat peripheral blood smear study with a nocturnally drawn sample revealed multiple microfilariae and a diagnosis of filariasis was made...
May 23, 2022: BMJ Case Reports
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