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JOURNAL ARTICLE
Krystallenia I Alexandraki, Ariadni Spyroglou, Paraskevi Xekouki, Konstantinos I Bramis, Georgios Kyriakopoulos, Konstantinos Barkas, Ioannis S Papanikolaou, George Mastorakos, Manousos Konstadoulakis
Von-Hippel-Lindau (VHL) is a genetic multisystem disorder characterized by visceral cysts and benign and malignant tumors in various organs. Herein, we present the case of a 23-year-old woman with VHL presenting with multiple gastric neuroendocrine neoplasms (gNENs) type 1 in the context of chronic autoimmune gastritis (CAG). Although gNENs are not acknowledged as a typical entity in VHL patients, in the present case, gNENs were composed of neoplastic cells with clear cytoplasm usually seen in tumors related to VHL disease...
April 15, 2024: Hormones: International Journal of Endocrinology and Metabolism
#22
JOURNAL ARTICLE
Sumer Jasmine, Adel Mandl, Timothy E G Krueger, Susan L Dalrymple, Lizamma Antony, Jennifer Dias, Cassandra A Celatka, Amy E Tapper, Maria Kleppe, Mayuko Kanayama, Yuezhou Jing, Valentina Speranzini, Yuzhuo Z Wang, Jun Luo, Bruce J Trock, Samuel R Denmeade, Michael A Carducci, Andrea Mattevi, Hugh Y Rienhoff, John T Isaacs, W Nathaniel Brennen
INTRODUCTION: Lysine-specific demethylase 1 (LSD1) is emerging as a critical mediator of tumor progression in metastatic castration-resistant prostate cancer (mCRPC). Neuroendocrine prostate cancer (NEPC) is increasingly recognized as an adaptive mechanism of resistance in mCRPC patients failing androgen receptor axis-targeted therapies. Safe and effective LSD1 inhibitors are necessary to determine antitumor response in prostate cancer models. For this reason, we characterize the LSD1 inhibitor bomedemstat to assess its clinical potential in NEPC as well as other mCRPC pathological subtypes...
April 15, 2024: Prostate
#23
JOURNAL ARTICLE
Michael K Wong, Cassian Yee
Merkel cell carcinoma (MCC) is an aggressive, fast-growing, highly metastatic neuroendocrine skin cancer. The Merkel cell polyomavirus (MCPyV) is an oncogenic driver in the majority of MCC tumors. In this issue of the JCI, Hansen and authors report on their tracking of CD8+ T cells reactive to MCPyV T antigen (T-Ag) in the peripheral blood of 26 patients with MCC who were undergoing frontline anti-programmed cell death protein-1 (anti-PD-1) immunotherapy. They discovered unique T cell epitopes and used the power of bar-coded tetramers to portray immune checkpoint inhibitor-induced immunogenicity as a predictor of clinical response...
April 15, 2024: Journal of Clinical Investigation
#24
JOURNAL ARTICLE
Tobias Else, Ka Kit Wong, Kirk A Frey, Allen F Brooks, Benjamin L Viglianti, David M Raffel
CONTEXT: Functional positron emission tomography (PET) imaging for the characterization of pheochromocytoma and paraganglioma (PCC/PGL) and for detection of metastases in malignant disease, offers valuable clinical insights that can significantly guide patient treatment. OBJECTIVE: This work aimed to evaluate a novel PET radiotracer, 3-[18 F]fluoro- para -hydroxyphenethylguanidine (3-[18 F]pHPG), a norepinephrine analogue, for its ability to localize PCC/PGL. METHODS: 3-[18 F]pHPG PET/CT whole-body scans were performed on 16 patients (8 male:8 female; mean age 47...
April 6, 2024: Journal of the Endocrine Society
#25
JOURNAL ARTICLE
Marc Spils, Thomas Klikovits, Dagmar Krenbek, Maximilian Johannes Hochmair, Igor Jankovic, Lisa Schulte, Tibor Krajc, Michal Benej, Vladyslav Getman, José Ruiz Navarrete, Ahmet Akan, Michael R Mueller, Clemens Aigner, Stefan B Watzka
BACKGROUND: Pulmonary carcinoids (PCs) are rare neuroendocrine lung tumors which may recur, thus worsening their otherwise favorable overall prognosis. Aiming to identify patients at risk for recurrence, we examined parameters affecting disease-free survival (DFS). METHODS: A retrospective single-center analysis of 82 consecutive patients undergoing curative intent resection for primary PC tumors between 2010 and 2019 was carried out. Kaplan-Meier method was utilized for survival analysis...
March 29, 2024: Journal of Thoracic Disease
#26
REVIEW
Somdatta Giri, Jayaprakash Sahoo
This editorial highlights the remarkable advancements in medical treatment strategies for pancreatic neuroendocrine tumors (pan-NETs), emphasizing tailored approaches for specific subtypes. Cytoreductive surgery and somatostatin analogs (SSAs) play pivotal roles in managing tumors, while palliative options such as molecular targeted therapy, peptide receptor radionuclide therapy, and chemotherapy are reserved for SSA-refractory patients. Gastrinomas, insulinomas, glucagonomas, carcinoid tumors and VIPomas necessitate distinct thera-peutic strategies...
March 28, 2024: World Journal of Gastroenterology: WJG
#27
JOURNAL ARTICLE
Lorenzo Gervaso, Alice Laffi, Aurora Gaeta, Sara Gandini, Laura Boldrini, Monica Isabel Meneses-Medina, Manila Rubino, Lavinia Benini, Michele Borghesani, Laura Algeri, Giuseppe Curigliano, Francesca Spada, Chiara Alessandra Cella, Nicola Fazio
No abstract text is available yet for this article.
March 2024: Research and Practice in Thrombosis and Haemostasis
#28
JOURNAL ARTICLE
Ling Zhao, Xinxin Hou, Yuanyuan Feng, Yingru Zhang, Shiyun Shao, Xinnan Wu, Junfeng Jim Zhang, Zhaozhou Zhang
Purpose: Mounting evidence indicates that psychological stress adversely affects cancer progression including tumor growth and metastasis. The aim of this study was to investigate the role of chronic stress-induced microbiome perturbation in colorectal cancer (CRC) progression. Methods: Chronic restraint stress (CRS) was used to establish the chronic stress mouse model, behavioral tests were used for the CRS model evaluation. Subcutaneous xenograft model and lung metastasis model were established to investigate the growth and metastasis of CRC promoted by CRS exposure...
2024: International Journal of Medical Sciences
#29
Yanlei Wang, Zhaoxiang Liu, Wenhui Zhao, Chenxiang Cao, Luqi Xiao, Jianzhong Xiao
BACKGROUND: Von Hippel-Lindau (VHL) syndrome is characterized by tumorous lesions affecting multiple organs. Pancreatic involvement in VHL syndrome can present as endocrine tumors and pancreatic cysts, which can interfere with both exocrine and endocrine functions of the pancreas. Diabetes is an uncommon complication of VHL syndrome. PURPOSE: This study aims to summarize the various mechanisms of diabetes in VHL syndrome by reporting two cases and conducting a literature review...
2024: Diabetes, Metabolic Syndrome and Obesity
#30
JOURNAL ARTICLE
Eden Gerszman, Esther Kazlow, Victoria Vlasov, Dvir Froylich, Jacob Dickstein, Riad Haddad, Ahmad Mahamid
No abstract text is available yet for this article.
April 2024: Israel Medical Association Journal: IMAJ
#31
JOURNAL ARTICLE
Purva H Rumde, Timothy F Burns
Residual cancer cells persist even after targeted therapies, serving as a reservoir for the subsequent acquisition of genetic alterations that lead to acquired drug resistance and tumor relapse. These initial drug-tolerant persisters (DTP) are phenotypically heterogenous with transient phenotypes attributed to epigenetic, metabolic, and cell-cycle changes. DTPs are responsible for the inevitable relapse seen in EGFR-mutant non-small cell lung cancer (NSCLC) despite high initial response to tyrosine kinase inhibitor (TKI) treatment...
April 15, 2024: Cancer Research
#32
JOURNAL ARTICLE
Susumu Hijioka, Daiki Yamashige, Minoru Esaki, Goro Honda, Ryota Higuchi, Toshihiko Masui, Yasuhiro Shimizu, Masayuki Ohtsuka, Yusuke Kumamoto, Akio Katanuma, Naoto Gotohda, Hirofumi Akita, Michiaki Unno, Itaru Endo, Yukihiro Yokoyama, Suguru Yamada, Ippei Matsumoto, Takao Ohtsuka, Satoshi Hirano, Hiroaki Yasuda, Manabu Kawai, Taku Aoki, Masafumi Nakamura, Daisuke Hashimoto, Toshiki Rikiyama, Akihiko Horiguchi, Tsutomu Fujii, Shugo Mizuno, Keiji Hanada, Masaji Tani, Takashi Hatori, Tetsuhide Ito, Masataka Okuno, Shingo Kagawa, Hiroshi Tajima, Tatsuya Ishii, Motokazu Sugimoto, Shunsuke Onoe, Hideki Takami, Ryoji Takada, Takayuki Miura, Yusuke Kurita, Keiko Kamei, Yuko Mataki, Kazuichi Okazaki, Yoshifumi Takeyama, Hiroki Yamaue, Sohei Satoi
BACKGROUND & AIMS: Despite previously reported treatment strategies for nonfunctioning small (≤20 mm) pancreatic neuroendocrine neoplasms (pNENs), uncertainties persist. We aimed to evaluate the surgically resected cases nonfunctioning small pNENs (NF-spNENs) in a large Japanese cohort to elucidate an optimal treatment strategy for NF-spNENs. METHODS: In this Japanese multicenter study, data were retrospectively collected from patients who underwent pancreatectomy between January 1996 and December 2019, were pathologically diagnosed with pNEN, and were treated according to the WHO 2019 classification...
April 12, 2024: Clinical Gastroenterology and Hepatology
#33
JOURNAL ARTICLE
Mareen S Kraus, Swathi Selvam, Iram Siddiqui, Jeanette A Reyes, Govind B Chavhan
PURPOSE: Gastrointestinal tract (GIT) tumors in children are rare and there is a scarcity of data on their imaging features. The purpose of this study was to determine thefrequency of various GIT tumor types in children and to identify key imaging characteristics. METHODS: This retrospective, single-center study was approved by the local ethics committee. Children with histologically proven GIT tumours (malignantand benign) who had imaging available on the institutional PACS between May 1, 2000 and Dec 31, 2019 were included...
April 10, 2024: European Journal of Radiology
#34
JOURNAL ARTICLE
C von Arx, G Della Vittoria Scarpati, L Cannella, O Clemente, A L Marretta, A Bracigliano, F Picozzi, D Iervolino, V Granata, R Modica, A Bianco, C Mocerino, A Di Mauro, A Pizzolorusso, A Di Sarno, A Ottaiano, S Tafuto
BACKGROUND: There is no consensus on the second-line treatment of patients with progressive high-grade neuroendocrine neoplasms (NENs G3) and large-cell lung neuroendocrine carcinoma. These patients generally have poor performance status and low tolerance to combination therapy. In this trial, we aim to evaluate the efficacy and safety of temozolomide given every other week in patients with advanced platinum-pretreated NENs G3. PATIENTS AND METHODS: This trial is an open-label, non-randomized, phase II trial...
April 13, 2024: ESMO Open
#35
REVIEW
Federica Guaraldi, Francesca Ambrosi, Costantino Ricci, Luisa Di Sciascio, Sofia Asioli
Somatotroph (GH) adenomas/PitNETs typically arise from adenohypophysis and are biochemically active, leading to acromegaly and gigantism. More rarely, they present with ectopic origin and do not present overt biochemical or clinical features (silent variants). Histopathological examination should consider the clinical and radiological background, and include multiple steps assessing tumor morphology, pituitary transcription factors (PTFs), hormone secretion, proliferation markers, granulation, and somatostatin receptors (STRs), aimed at depicting as better as possible tumor origin (in case of non-functioning and/or metastatic tumor), and clinical behavior, including response to treatment...
April 2, 2024: Best Practice & Research. Clinical Endocrinology & Metabolism
#36
JOURNAL ARTICLE
Zhikai Chi, Jing Xu, Dipti M Karamchandani, Lan Peng
INTRODUCTION: Differentiating pancreatic serous cystadenoma (SCA) from well-differentiated neuroendocrine tumors (WDNETs) based on histomorphology is critical yet challenging, particularly in small biopsy samples. Our study aimed to examine the expression profile of INSM1 in cytologic and surgical resection specimens from pancreatic SCA to evaluate its potential as a discriminative marker against pancreatic WDNET. METHODS: We characterized INSM1 immunohistochemistry in 34 patients with pancreatic SCA, comprising 23 surgical resections and 11 cytology specimens...
April 9, 2024: Annals of Diagnostic Pathology
#37
JOURNAL ARTICLE
Maria Ingenerf, Christoph Auernhammer, Roberto Lorbeer, Michael Winkelmann, Shiwa Mansournia, Nabeel Mansour, Nina Hesse, Kathrin Heinrich, Jens Ricke, Frank Berger, Christine Schmid-Tannwald
BACKGROUND: This study explores the predictive and monitoring capabilities of clinical and multiparametric MR parameters in assessing capecitabine and temozolomide (CAPTEM) therapy response in patients with neuroendocrine tumors (NET). PATIENTS AND METHODS: This retrospective study (n = 44) assessed CAPTEM therapy response in neuroendocrine liver metastases (NELM) patients. Among 33 monitored patients, as a subgroup of the overall study cohort, pretherapeutic and follow-up MRI data (size, apparent diffusion coefficient [ADC] values, and signal intensities), along with clinical parameters (chromogranin A [CgA] and Ki-67%), were analyzed...
April 14, 2024: Radiology and Oncology
#38
JOURNAL ARTICLE
Genesio Di Muro, Rosa Catalano, Donatella Treppiedi, Anna Maria Barbieri, Federica Mangili, Giusy Marra, Sonia Di Bari, Emanuela Esposito, Emma Nozza, Andrea G Lania, Emanuele Ferrante, Marco Locatelli, Daniela Modena, Christian Steinkuhler, Erika Peverelli, Giovanna Mantovani
Somatostatin receptor ligands (SRLs) with high affinity for somatostatin receptors 2 and 5 (SSTR2 and SSTR5) are poorly efficacious in NF-PitNETs, expressing high levels of SSTR3. ITF2984 is a pan-SSTR ligand with high affinity for SSTR3, able to induce SSTR3 activation and to exert antitumoral activity in the MENX rat model. The aim of this study was to test ITF2984's antiproliferative and proapoptotic effects in NF-PitNET primary cultured cells derived from surgically removed human tumors and to characterize their SSTR expression profile...
March 23, 2024: International Journal of Molecular Sciences
#39
JOURNAL ARTICLE
Yun-Chen Chang, Yu-Ning Tsao, Chi-Cheng Chuang, Cheng-Yu Li, Ta-Jen Lee, Chia-Hsiang Fu, Kuo-Chen Wei, Chi-Che Huang
(1) Background: Transsphenoidal pituitary surgery can be conducted via microscopic or endoscopic approaches, and there has been a growing preference for the latter in recent years. However, the occurrence of rare complications such as postoperative sinusitis remains inadequately documented in the existing literature. (2) Methods: To address this gap, we conducted a comprehensive retrospective analysis of medical records spanning from 2018 to 2023, focusing on patients who underwent transsphenoidal surgery for pituitary neuroendocrine tumors (formerly called pituitary adenoma)...
April 2, 2024: Diagnostics
#40
REVIEW
Chiara Castellana, Leonardo Henry Eusebi, Elton Dajti, Veronica Iascone, Amanda Vestito, Pietro Fusaroli, Lorenzo Fuccio, Antonietta D'Errico, Rocco Maurizio Zagari
Autoimmune atrophic gastritis (AAG) is a chronic condition characterized by the presence of atrophy in the oxyntic mucosa due to anti-parietal cell antibodies. This review provides a comprehensive and up-to-date overview of autoimmune atrophic gastritis, reporting recent evidence on epidemiology, pathogenesis, diagnosis, clinical presentation, risk of malignancies, and management. The prevalence of AAG has been estimated at between 0.3% and 2.7% in the general population. The diagnosis of AAG is based on a combination of the serologic profile and the histological examination of gastric biopsies...
March 28, 2024: Cancers
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