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noninvasive vascular imaging

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https://www.readbyqxmd.com/read/29341020/mri-in-the-study-of-animal-models-of-stroke
#1
Pedro Ramos-Cabrer, Daniel Padro
Stroke consists of the loss of cerebral functions resulting from the interruption of blood supply to a region of the brain, and represents the second cause of death and the leading cause of major disability in adults in Europe. Stroke is a very active field of research at preclinical and clinical levels, and Magnetic Resonance Imaging (MRI) is one of the most powerful tools that scientist and clinicians have for the study of the onset, evolution and consequences of this devastating disease, as well as for the monitoring of the success of available treatments, or for the development of novel therapeutic strategies...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29335512/label-free-photoacoustic-imaging-of-human-palmar-vessels-a-structural-morphological-analysis
#2
Y Matsumoto, Y Asao, A Yoshikawa, H Sekiguchi, M Takada, M Furu, S Saito, M Kataoka, H Abe, T Yagi, K Togashi, M Toi
We analysed the vascular morphology of the palm using a photoacoustic tomography (PAT) instrument with a hemispherical detector array. The three-dimensional (3D) morphology of blood vessels was determined noninvasively. Overall, 12 females and 11 males were recruited as healthy volunteers. Their ages were distributed almost evenly from 22 to 59 years. In all cases, many vascular networks were observed just beneath the skin and were determined to be veins anatomically. To analyse the major arteries, the layer containing the subcutaneous venous network was removed from the image...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29334118/markers-of-proliferation-and-invasiveness-in-somatotropinomas
#3
Agata Baldys-Waligorska, Iga Wierzbicka, Grzegorz Sokolowski, Dariusz Adamek, Filip Golkowski
IntroductionIn the search for markers of invasiveness of pituitary adenomas, we studied the expression of Ki-67 antigen, TOPO 2A (topoisomerase 2 alpha), AIP (Aryl Hydrocarbon Receptor-Interacting Protein) and VEGF (Vascular Endothelial Growth Factor) in somatotropinomas.Material and MethodsWe retrospectively studied a group of 31 patients who underwent pituitary tumour surgery. Expression of Ki-67, TOPO 2A, AIP and VEGF in surgical specimens was determined by immunohistochemistry. Relations between quantitatively determined markers and clinical symptoms, tumour features, and MR imaging, were analysed...
January 15, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29325389/-development-of-en-face-optical-coherence-tomography-and-its-application-in-ocular-fundus-diseases
#4
Y Zhou, M Wang
Optical coherence tomography (OCT) is able to obtain the cross-sectional image of the fundus noninvasively and quickly. The cross-sectional image in vivo almost matches the histological section of the retina. OCT has become the most important imaging tool in ophthalmology. Based on the latest OCT technology, en face OCT is a new imaging technique that reveals the structure of retinal and choroidal sections approximately paralleled to the retina surface. Compared to the conventional OCT, en face OCT provides more comprehensive information and makes more accurate diagnosis and assessment of the prognosis...
December 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29320993/distribution-of-glomerular-diseases-in-taiwan-preliminary-report-of-national-renal-biopsy-registry-publication-on-behalf-of-taiwan-society-of-nephrology
#5
Hsien-Fu Chiu, Hung-Chun Chen, Kuo-Cheng Lu, Kuo-Hsiung Shu
BACKGROUND: Despite the development of biomarkers and noninvasive imaging tools, biopsy remains the only method for correctly diagnosing patients with unexplained hematuria, proteinuria and renal failure. Renal biopsy has been performed for several decades in Taiwan; however, a national data registry is still lacking until 2013. METHODS: The Renal Biopsy Registry Committee was established within the Taiwan Society of Nephrology in January 2013. A biopsy registry format, including basic demographic data, baseline clinical features, laboratory data, and clinical and pathological diagnosis was developed...
January 10, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29290819/identification-of-type-iv-collagen-exposure-as-a-molecular-imaging-target-for-early-detection-of-thoracic-aortic-dissection
#6
Ke Xu, Chen Xu, Yanzhenzi Zhang, Feiran Qi, Bingran Yu, Ping Li, Lixin Jia, Yulin Li, Fu-Jian Xu, Jie Du
Thoracic aortic dissection (TAD) is an aggressive and life-threatening vascular disease and there is no effective means of early diagnosis of dissection. Type IV collagen (Col-IV) is a major component of the sub-endothelial basement membrane, which is initially exposed followed by endothelial injury as early-stage event of TAD. So, we want to build a noninvasive diagnostic method to detect early dissection by identifying the exposed Col-IV via MRI. METHODS: Col-IV-targeted magnetic resonance/ fluorescence dual probe (Col-IV-DOTA-Gd-rhodamine B; CDR) was synthesized by amide reaction and coordination reaction...
2018: Theranostics
https://www.readbyqxmd.com/read/29288902/diagnostic-evaluation-and-surgical-management-of-pediatric-insular-epilepsy-utilizing-magnetoencephalography-and-invasive-eeg-monitoring
#7
Raheel Ahmed, Hiroshi Otsubo, Carter Snead, Elizabeth Donner, Elysa Widjaja, Ayako Ochi, James M Drake, James T Rutka
INTRODUCTION: The diagnosis and surgical management of pediatric patients with insular epilepsy is challenging due to variable and indistinct seizure semiology arising within the insular cortex. In addition, surgical approaches are associated with potential morbidity given the regional neurosurgical and vascular anatomy. Our institutional experience in evaluation and surgical management of insular epilepsy patients is presented. Diagnostic evaluation, surgical treatment and seizures outcomes are highlighted...
December 20, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29278545/treatment-effect-of-balloon-pulmonary-angioplasty-in-chronic-thromboembolic-pulmonary-hypertension-quantified-by-automatic-comparative-imaging-in-computed-tomography-pulmonary-angiography
#8
Zhiwei Zhai, Hideki Ota, Marius Staring, Jan Stolk, Koichiro Sugimura, Kei Takase, Berend C Stoel
OBJECTIVES: Balloon pulmonary angioplasty (BPA) in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH) can have variable outcomes. To gain more insight into this variation, we designed a method for visualizing and quantifying changes in pulmonary perfusion by automatically comparing computed tomography (CT) pulmonary angiography before and after BPA treatment. We validated these quantifications of perfusion changes against hemodynamic changes measured with right-sided heart catheterization...
December 22, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/29238728/retinal-photoreceptors-and-microvascular-changes-in-prediabetes-measured-with-adaptive-optics-rtx1%C3%A2-a-case-control-study
#9
Anna Zaleska-Żmijewska, Paweł Piątkiewicz, Barbara Śmigielska, Anna Sokołowska-Oracz, Zbigniew M Wawrzyniak, Dorota Romaniuk, Jerzy Szaflik, Jacek P Szaflik
Background: Patients with prediabetes are at risk for diabetes, cardiovascular events, and microvascular complications. The rtx1 (Imagine Eyes, France) permits early detection of changes in the retinal photoreceptors and vessels. Objective: Cone parameters and retinal microvasculature were analyzed with the rtx1 in 12 prediabetic patients and 22 healthy subjects. The analysis was based on cone density (DM), interphotoreceptor distance (SM), cone packing regularity, and retinal vessel parameters: wall thickness, lumen diameter (LD), wall-to-lumen ratio (WLR), and cross-sectional area of the vascular wall...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29225397/concurrent-oct-imaging-of-stimulus-evoked-retinal-neural-activation-and-hemodynamic-responses
#10
Taeyoon Son, Benquan Wang, Yiming Lu, Yanjun Chen, Dingcai Cao, Xincheng Yao
It is well established that major retinal diseases involve distortions of the retinal neural physiology and blood vascular structures. However, the details of distortions in retinal neurovascular coupling associated with major eye diseases are not well understood. In this study, a multi-modal optical coherence tomography (OCT) imaging system was developed to enable concurrent imaging of retinal neural activity and vascular hemodynamics. Flicker light stimulation was applied to mouse retinas to evoke retinal neural responses and hemodynamic changes...
2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/29206760/development-of-noninvasive-in-vivo-approach-to-assess-vascular-permeability-in-inflammation-using-fluorescence-imaging
#11
Takashi Shimazui, Taka-Aki Nakada, Lisa Fujimura, Akemi Sakamoto, Masahiko Hatano, Shigeto Oda
INTRODUCTION: In vivo fluorescence imaging can quantify vascular permeability without requiring sacrifice of animals. However, use of this noninvasive approach for vascular permeability assessment in remote organ injury caused by systemic inflammatory disease has not been reported. METHODS: Evans blue (EB) and Genhance 750 fluorescent dye were mixed and injected into mice. The lung as a remote organ and the footpad as a noninvasive observational site were assessed in a cecal ligation and puncture (CLP)-induced systemic inflammation mouse model and compared with sham and hydrocortisone pretreated (CLP + HC) mouse models...
December 4, 2017: Shock
https://www.readbyqxmd.com/read/29204016/usefulness-of-pulsed-arterial-spin-labeling-magnetic-resonance-imaging-in-new-onset-seizure-patients-and-its-comparison-with-dynamic-susceptibility-contrast-magnetic-resonance-imaging
#12
Varun Bansal, Suresh Kumar, Sudhir Sharma, Sanjiv Sharma, R G Sood
Introduction: Dynamic susceptibility contrast (DSC) perfusion and pulsed arterial spin labeling (PASL) imaging are newer advanced magnetic resonance sequences which are capable of detecting vascular changes in patients with new-onset seizure disorder even when no significant abnormalities are visualized on conventional sequences. The purpose of our study is to establish utility of arterial spin labeling (ASL) in new-onset seizure patients and compare ASL with DSC perfusion sequence. Materials and Methods: Twenty-six patients coming to emergency department with new-onset seizure disorder were evaluated using DSC and ASL sequence...
October 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/29200855/vascular-thrombus-imaging-in-vivo-via-near-infrared-fluorescent-nanodiamond-particles-bioengineered-with-the-disintegrin-bitistatin-part-ii
#13
Jonathan A Gerstenhaber, Frank C Barone, Cezary Marcinkiewicz, Jie Li, Aaron O Shiloh, Mark Sternberg, Peter I Lelkes, Giora Feuerstein
The aim of this feasibility study was to test the ability of fluorescent nanodiamond particles (F-NDP) covalently conjugated with bitistatin (F-NDP-Bit) to detect vascular blood clots in vivo using extracorporeal near-infrared (NIR) imaging. Specifically, we compared NIR fluorescence properties of F-NDP with N-V (F-NDPNV) and N-V-N color centers and sizes (100-10,000 nm). Optimal NIR fluorescence and tissue penetration across biological tissues (rat skin, porcine axillary veins, and skin) was obtained for F-NDPNV with a mean diameter of 700 nm...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29189425/remodeling-failing-human-myocardium-with-hybrid-cell-matrix-and-transmyocardial-revascularization
#14
Ryan J Avery, Soojie K Yu, Gopi Cherukuri, Ray B Runyan, John Konhilas, Zain I Khalpey
Given the limited treatment options for advanced heart failure, the intrinsic regenerative properties of stem cells have been evaluated for myocardial remodeling. Previous stem cells techniques for myocardiocyte remodeling have been limited by the low cellular retention. Presented is a hybrid approach for remodeling infarcted myocardium through implantation of allogeneic human amniotic fluid-derived mesenchymal stem cells within micronized human allograft-derived liquid matrix during the performance of transmyocardial revascularization (TMR)...
November 14, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29178413/in-vivo-reflectance-confocal-microscopy-in-daily-practice-image-features-correlated-to-histopathology
#15
Z-Y Pan, D-K Dong, S-J Chen, L-Y Lu, T-T Hu, Q Ju
BACKGROUND: In vivo reflectance confocal microscopy (RCM) represents a promising technique for noninvasive visualization of skin lesions. In the clinical daily practice, doctors want to know the relationship between the RCM images and the skin pathological changes. OBJECTIVE: The aim of this study was to identify the basic skin pathological changes under RCM, and use RCM terminology to describe these pathological changes. METHODS: A total of 100 patients were recruited and were evaluated both by RCM and histopathologic examination...
November 27, 2017: Skin Research and Technology
https://www.readbyqxmd.com/read/29171085/contrast-enhanced-ultrasound-examination-for-the-assessment-of-renal-perfusion-in-cats-with-chronic-kidney-disease
#16
E Stock, D Paepe, S Daminet, E Vandermeulen, L Duchateau, J H Saunders, K Vanderperren
BACKGROUND: Contrast-enhanced ultrasound examination (CEUS) is a functional imaging technique allowing noninvasive assessment of tissue perfusion. Studies in humans show that the technique holds great potential to be used in the diagnosis of chronic kidney disease (CKD). However, data in veterinary medicine are currently lacking. OBJECTIVES: To evaluate renal perfusion using CEUS in cats with CKD. ANIMALS: Fourteen client-owned cats with CKD and 43 healthy control cats...
November 24, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29159819/focal-nodular-hyperplasia-of-the-liver-contrast-enhanced-ultrasonographic-features-with-sonazoid
#17
Jongmee Lee, Woo Kyoung Jeong, Hyo K Lim, Ah Young Kim
OBJECTIVES: To investigate ultrasonographic features of focal nodular hyperplasia of the liver with contrast-enhanced ultrasonography (CEUS) using Sonazoid (perflubutane; GE Healthcare, Oslo, Norway). METHODS: Thirty-one patients with 31 focal nodular hyperplasia nodules who underwent CEUS using Sonazoid between July 2012 and February 2015 were included in this study. After the microbubble contrast agent was injected, intermittent CEUS images were obtained during the following 4 phases: arterial (10-40 seconds), portal venous (60-90 seconds), delayed (3 minutes), and Kupffer (>10 minutes)...
November 21, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29146749/statins-promote-cardiac-infarct-healing-by-modulating-endothelial-barrier-function-revealed-by-contrast-enhanced-magnetic-resonance-imaging
#18
Geert J Leenders, Mirjam B Smeets, Maaike van den Boomen, Monique Berben, Miranda Nabben, Dianne van Strijp, Gustav J Strijkers, Jeanine J Prompers, Fatih Arslan, Klaas Nicolay, Katrien Vandoorne
OBJECTIVE: The endothelium has a crucial role in wound healing, acting as a barrier to control transit of leukocytes. Endothelial barrier function is impaired in atherosclerosis preceding myocardial infarction (MI). Besides lowering lipids, statins modulate endothelial function. Here, we noninvasively tested whether statins affect permeability at the inflammatory (day 3) and the reparative (day 7) phase of infarct healing post-MI using contrast-enhanced cardiac magnetic resonance imaging...
November 16, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29142489/correlation-between-osteoprotegerin-serum-level-and-coronary-calcification-using-coronary-artery-calcium-score-in-patient-with-moderate-severe-cardiovascular-risk-factor
#19
J Nugroho, Widorini Widorini
Coronary artery calcification is a part of atherosclerosis process associated with coronary heart disease. Recently, coronary artery calcification assessment using computed tomography (CT) is still the best noninvasive imaging with high sensitivity and specificity. Osteoprotegerin (OPG) is one of vascular calcification marker that through its role to bind receptor activator of nuclear factor-κβ ligand and inhibit osteoclastogenesis is suspected of playing a role for coronary calcification in atherosclerosis process...
December 2017: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/29137019/optical-coherence-tomography-angiography-in-patients-with-diabetic-retinopathy-treated-with-anti-vegf-intravitreal-injections-case-report
#20
Katarzyna Michalska-Małecka, Anna Heinke Knudsen
PURPOSE: To present optical coherence tomography angiography (OCTA) features in patients with diabetic retinopathy (DR) at the baseline and in response to treatment with anti-VEGF intravitreal injections. To investigate the role of OCTA in management of patients with DR. METHODS: Retrospective case series showing primary outcomes of 3 patients with DR and diabetic macular edema. Patients were injected intravitreally a loading phase of 3 monthly 2.0 mg aflibercept, followed by 2 injections bimonthly (5 injections in total)...
November 2017: Medicine (Baltimore)
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