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https://www.readbyqxmd.com/read/27912112/ethnic-variation-of-genetic-idiopathic-generalized-epilepsy-in-malaysia
#1
Kheng Seang Lim, Ching Ching Ng, Chung Kin Chan, Wee Shean Foo, Joyce Siew Yong Low, Chong Tin Tan
PURPOSE: Ethnic variation in epilepsy classification was reported in the Epilepsy Phenome/Genome Project. This study aimed to determine the ethnic variation in the prevalence of genetic (idiopathic) generalized epilepsy (GGE) and GGE with family history in a multi-ethnic Asian population in Malaysia. METHOD: In this cross-sectional study, 392 patients with a clinical diagnosis of GGE were recruited in the neurology outpatient clinic, University of Malaya Medical Centre (UMMC), from January 2011 till April 2016...
November 24, 2016: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/27848937/reconstructing-druze-population-history
#2
Scarlett Marshall, Ranajit Das, Mehdi Pirooznia, Eran Elhaik
The Druze are an aggregate of communities in the Levant and Near East living almost exclusively in the mountains of Syria, Lebanon and Israel whose ~1000 year old religion formally opposes mixed marriages and conversions. Despite increasing interest in genetics of the population structure of the Druze, their population history remains unknown. We investigated the genetic relationships between Israeli Druze and both modern and ancient populations. We evaluated our findings in light of three hypotheses purporting to explain Druze history that posit Arabian, Persian or mixed Near Eastern-Levantine roots...
November 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27818530/religion-marriage-markets-and-assortative-mating-in-the-united-states
#3
David McClendon
As interfaith marriage has become more common, religion is thought to be less important for sorting partners. However, prior studies on religious assortative mating use samples of prevailing marriages, which miss how local marriage markets shape both partner selection and marriage timing. Drawing on search theory and data from 8,699 young adults (ages 18-31) in the National Longitudinal Study of Youth 1997, the author examined the association between the concentration of co-religionists in local marriage markets and marriage timing and partner selection using event history methods...
October 2016: Journal of Marriage and the Family
https://www.readbyqxmd.com/read/27794482/the-role-of-testosterone-in-coordinating-male-life-history-strategies-the-moderating-effects-of-the-androgen-receptor-cag-repeat-polymorphism
#4
Lee T Gettler, Calen P Ryan, Dan T A Eisenberg, Margarita Rzhetskaya, M Geoffrey Hayes, Alan B Feranil, Sonny Agustin Bechayda, Christopher W Kuzawa
Partnered fathers often have lower testosterone than single non-parents, which is theorized to relate to elevated testosterone (T) facilitating competitive behaviors and lower T contributing to nurturing. Cultural- and individual-factors moderate the expression of such psychobiological profiles. Less is known about genetic variation's role in individual psychobiological responses to partnering and fathering, particularly as related to T. We examined the exon 1 CAG (polyglutamine) repeat (CAGn) within the androgen receptor (AR) gene...
October 26, 2016: Hormones and Behavior
https://www.readbyqxmd.com/read/27756459/progress-in-the-mathematical-modelling-of-visceral-leishmaniasis
#5
K S Rock, R J Quinnell, G F Medley, O Courtenay
The leishmaniases comprise a complex of diseases characterized by clinical outcomes that range from self-limiting to chronic, and disfiguring and stigmatizing to life threatening. Diagnostic methods, treatments, and vector and reservoir control options exist, but deciding the most effective interventions requires a quantitative understanding of the population level infection and disease dynamics. The effectiveness of any set of interventions has to be determined within the context of operational conditions, including economic and political commitment...
2016: Advances in Parasitology
https://www.readbyqxmd.com/read/27747681/mood-personality-and-behavior-changes-during-treatment-with-statins-a-case-series
#6
Stephanie Cham, Hayley J Koslik, Beatrice A Golomb
Psychiatric adverse drug reactions (ADRs) have been reported with statin use, but the literature regarding statin-associated mood/behavioral changes remains limited. We sought to elicit information germane to natural history and characteristics of central nervous system/behavioral changes in apparent connection with statin and/or cholesterol-lowering drug use, and delineate mechanisms that may bear on an association. Participants (and/or proxies) self-referred with behavioral and/or mood changes in apparent association with statins completed a survey eliciting cholesterol-lowering drug history, character and impact of behavioral/mood effect, time-course of onset and recovery in relation to drug use/modification, co-occurrence of recognized statin-associated ADRs, and factors relevant to ADR causality determination...
December 2016: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/27740921/association-between-exposure-to-sexually-explicit-content-in-the-electronic-media-and-sexual-intentions-of-in-school-adolescents-in-southwest-nigeria
#7
Josephine Adeolu, Eme Owoaje, Adesola Olumide
BACKGROUND: Many adolescents are exposed to a significant amount of sexual content in the media. This has far-reaching effects on their sexual practices as this exposure is occurring at a period when most adolescents are often not sure of the choices to make, and the choices they make during adolescence affect their health when they become adults. The aim of this study was to assess the association between exposure of in-school adolescents to sexual content in the electronic media and their sexual intentions...
October 14, 2016: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/27730080/demographic-and-clinical-characteristics-of-the-children-with-aminoacidopathy-in-isfahan-province-central-iran-in-2007-2015
#8
Reza Najafi, Mahin Hashemipour, Omid Yaghini, Fatemeh Najafi, Amirsalar Rashidianfar
CONTEXT: Aminoacidopathies refer to defects in protein synthesis pathways which result in a range of biochemical disorders and clinical presentations. The enzyme defects in intermediate metabolic pathways lead to accumulation of one or more amino acids or metabolites. Despite higher prevalence rates, screening infants for inherited metabolic disorders is not run in many Middle East countries. AIM: This research is part of a larger study of inherited metabolic disorders to characterize and measure the prevalence of aminoacidopathies...
September 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27703943/slipped-distal-femoral-epiphysis-in-congenital-insensitivity-to-pain
#9
M Javed Shaikh, C Rex, R Vignesh, Madhav Chavan
INTRODUCTION: Congenital insensitivity to pain (CIP) is a rare disorder, and often presents to an orthopaedic surgeon as recurrent fractures, dislocations, pseudoarthrosis, osteomyelitis etc. Here, we report a case of congenital insensitivity to pain presenting with distal femoral physeal separation in a child. CASE REPORT: A 12-year-old girl child came with complaints of limp while walking and swelling in the left knee for past 5 weeks. Mother gave a history that the girl is a known case of congenital insensitivity to pain with clear history of no pain on intramuscular injection since birth...
April 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/27699571/clinical-immunological-and-molecular-findings-of-patients-with-p47-phox-defect-chronic-granulomatous-disease-cgd-in-indian-families
#10
Manasi Kulkarni, Mukesh Desai, Maya Gupta, Aparna Dalvi, Prasad Taur, Antony Terrance, Sunil Bhat, Mamta Manglani, Revathi Raj, Ira Shah, Manisha Madkaikar
Chronic granulomatous disease (CGD) is a group of inherited disorder of phagocytes, resulting from mutations in the components of the NADPH oxidase complex. Reduced or absent oxygen radical synthesis seen in these patients leads to impaired killing of intracellular bacteria and fungi. CGD clinically presents with recurrent and life-threatening infections as well as granulomatous inflammatory responses. p47(phox) encoded by the NCF1 gene is the most common autosomal recessive form of CGD which is often clinically milder...
October 3, 2016: Journal of Clinical Immunology
https://www.readbyqxmd.com/read/27680221/a-case-of-cerebrotendinous-xanthomatosis-mimicking-the-clinical-phenotype-of-mitochondrial-disease-with-a-novel-frame-shift-mutation-c-43_44-delgg-in-cyp27a1-gene-exon-1
#11
Junpei Koge, Shintaro Hayashi, Hiroo Yamaguchi, Takahisa Tateishi, Hiroyuki Murai, Jun-Ichi Kira
A 37-old-male with a history of early childhood mental retardation was admitted to our hospital. He experienced recurrent syncopes at 23 years old, and at age 35 gait disturbance and hearing impairment developed gradually and worsened over time. His grandparents were in a consanguineous marriage. He was of short stature and absent of tendon xanthomas. Neurological examinations revealed scanning speech, dysphagia, right sensorineural hearing loss, spasticity in both upper and lower extremities, and spastic gait...
September 28, 2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/27666004/the-10-year-trend-of-adult-diabetes-prediabetes-and-associated-risk-factors-in-tehran-phases-1-and-4-of-tehran-lipid-and-glucose-study
#12
Niroomand Mahtab, Hadaegh Farzad, Bahaeddini Mohsen, Darvishi Nakisa
BACKGROUND: Type 2 diabetes is a global problem with significant morbidity and healthcare costs. In this study, we aimed to determine the 10-year trend of diabetes, prediabetes and their risk factors in the adult urban population of Tehran Lipid and Glucose Study (TLGS). MATERIALS AND METHODS: In this cross-sectional study, we included all patients above 20 years of age who were registered in phases 1 and 4 of TLGS. Each phase had a 3-year duration. 4580 patients were recruited in each phase (916 patients in each age-group, including 3772 males and 5145 females)...
September 15, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/27632780/impact-of-consanguineous-marriages-and-degrees-of-inbreeding-on-fertility-child-mortality-secondary-sex-ratio-selection-intensity-and-genetic-load-a-cross-sectional-study-from-northern-india
#13
Mohd Fareed, Mir Kaisar Ahmad, Malik Azeem Anwar, Mohammad Afzal
BACKGROUND: The aim of our study was to understand the relationship between consanguineous marriages and reproductive outcomes. METHODS: A total of 999 families were recruited from five Muslim populations of Jammu region. Family pedigrees were drawn to access the family history and inbreeding status in terms of coefficient of inbreeding (F). Fertility, mortality, secondary sex ratio, selection intensity, and lethal equivalents were measured using standard methods...
October 12, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27617243/age-at-natural-menopause-and-related-factors-in-isfahan-iran
#14
Parastoo Golshiri, Mojtaba Akbari, Mohammad Reza Abdollahzadeh
OBJECTIVE: This study was aimed to evaluate the age at natural menopause and related factors among women in a population based study in 2015 in Isfahan, Islamic Republic of Iran. METHODS: In this cross-sectional study 960 menopausal women were selected by cluster sampling. Demographic, socioeconomic, lifestyle behavior and reproductive history aspects were collected using a structured questionnaire. Woman and her husband's educational level and occupation with family income were the variables to construct socioeconomic status using principal component analysis...
August 2016: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/27614865/interaction-between-diabetes-mellitus-and-hypertension-on-risk-of-hearing-loss-in-highly-endogamous-population
#15
Abdulbari Bener, Abdulla O A A Al-Hamaq, Khalid Abdulhadi, Ahmed H Salahaldin, Loida Gansan
AIM: The aim of this study was to determine the prevalence of hearing loss and its association with type 2 diabetes mellitus (T2DM) in a highly endogamous population. DESIGN: This is a cross-sectional study. SETTING: The present study is carried out in Ear Nose Throat (ENT) and Endocrinology outpatient clinics of the Hamad General and Rumeilah Hospitals, Hamad Medical Corporation. SUBJECTS: All subjects aged between 20 and 59 years who visited the Endocrinology and ENT outpatient clinics of the Hamad Medical Corporation with hearing difficulty were included in this study during the period from January 2013 to July 2014...
September 5, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/27602192/risk-factors-and-plasma-glucose-profile-of-gestational-diabetes-in-omani-women
#16
Havagiray R Chitme, Sumaiya Abdallah Said Al Shibli, Raya Mahmood Al-Shamiry
OBJECTIVES: We sought to conduct a detailed study on the risk factors of gestational diabetes mellitus (GDM) in Omani women to determine the actual and applicable risk factors and glucose profile in this population. METHODS: We conducted a cross-sectional case-control study using pregnant women diagnosed with GDM. Pregnant women without GDM were used as a control group. We collected information related to age, family history, prior history of pregnancy complications, age of marriage, age of first pregnancy, fasting glucose level, and oral glucose tolerance test (OGTT) results from three hospitals in Oman through face-to-face interviews and hospital records...
September 2016: Oman Medical Journal
https://www.readbyqxmd.com/read/27592581/knowledge-for-unintentional-injury-and-risky-behavior-among-the-school-age-children-in-changsha-city-of-china
#17
Lingyun Tian, Minhui Liu, Li Li, Zhengqing Fang, Hongling Xiao, Ying Wu, Yanping Xia
OBJECTIVE: To investigate the current status on knowledge for unintentional injury and risky behavior among school-age children in Changsha, China, and to provide scientific evidence for the preventive strategies.
 METHODS: A cross-sectional study was conducted on 866 students who were between 6 and 12 years old in Changsha. Two primary schools were selected by stratified cluster random sampling from all primary schools of Changsha city to collect the information regarding knowledge for unintentional injury and risky behavior occurring in the 6-month period before the survey...
July 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/27587934/the-relationship-between-resettlement-and-birth-rates-the-case-of-gambella-ethiopia
#18
Aynalem Adugna, Helmut Kloos
BACKGROUND: This study aims to examine the possible impacts of resettlement on birth rates by using the length of stay variable in the 2000 Demographic and Health Survey (DHS). METHODS: Data in all three rounds of Gambella Administrative Region's Demographic and Health Surveys (DHS) are analyzed. The neighboring administrative region of Benishangul-Gumuz is used as a control. The multivariate analysis of variance (MANOVA) is applied with duration of residence as a categorical independent variable...
July 2016: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/27574963/direct-and-indirect-costs-of-nonfatal-road-traffic-injuries-in-iran-a-population-based-study
#19
Hasti Karimi, Saeed Soleyman-Jahi, Nima Hafezi-Nejad, Afarin Rahimi-Movaghar, Masoumeh Amin-Esmaeili, Vandad Sharifi, Ahmad Hajebi, Soheil Saadat, Ali Akbari Sari, Vafa Rahimi-Movaghar
OBJECTIVES: The objective of this study was to assess the incidence rate as well as direct and indirect costs of nonfatal road traffic injuries (RTIs) in Iran in 2011. METHODS: Data from the 2011 national household survey were used. In this survey, data on demographics, history, and costs of injury were obtained in 2 steps: first, direct face-to-face interview and second, telephone calls. We estimated the incidence rate of nonfatal RTIs in this year. The direct costs included medical care as well as nonmedical costs paid by the patient or insurance services...
August 30, 2016: Traffic Injury Prevention
https://www.readbyqxmd.com/read/27558563/assessment-of-perceived-stress-related-to-migration-and-acculturation-in-patients-with-psychiatric-disorders-migstr10-development-reliability-and-dimensionality-of-a-brief-instrument
#20
Matthias J Müller, Sabrina Zink, Eckhardt Koch
Assessment of stressors related to migration and acculturation in patients with psychiatric disorder and migration background could help improve culturally sensitive concepts of psychiatry and psychotherapy for diagnosis and treatment. The present overview delineates development and psychometric properties of an instrument (MIGSTR10) for assessment of stressors related to migration and acculturation, particularly for application in patients with psychiatric disorders. Ten migration-related stressors were derived from a qualitative content analysis of case histories of patients with psychiatric disorder and migration background and put into a suitable interview and questionnaire format (MIGSTR10; 10 questions, answer format: categorical yes/no, and dimensional 0-10) for self-assessment and observer ratings in several languages...
August 24, 2016: Psychiatric Quarterly
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