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wilms tumor review

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https://www.readbyqxmd.com/read/27878779/total-estimated-effective-doses-from-radiologic-imaging-modalities-of-children-with-cancer-a-single-center-experience
#1
Derya Özyörük, Suna Emir, Hacı Ahmet Demir, Gülşah Bayram Kabaçam, Bahattin Tunç
BACKGROUND: Recently, awareness of the cumulative radiation exposure for pediatric oncology patients has been increasing, together with increased survival rates and longer life expectancy. The aim of our study was to quantify the amount of ionising radiation from imaging modalities of pediatric oncology patients. METHODS: Eighty-eight patients who were diagnosed with childhood cancer and followed up for 5 years between 2004-2014 in our center were included in the study...
November 23, 2016: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/27856008/comprehensive-renal-function-evaluation-in-patients-treated-for-synchronous-bilateral-wilms-tumor
#2
Rodrigo B Interiano, M Beth McCarville, Noel Delos Santos, Shenghua Mao, Jianrong Wu, Jeffrey S Dome, Kathleen Kieran, Mark A Williams, Rachel C Brennan, Matthew J Krasin, Daniel M Green, Andrew M Davidoff
OBJECTIVES: The purpose of this study was to perform a comprehensive assessment of long-term renal function in patients treated at our institution for synchronous bilateral Wilms tumor (BWT) and to determine the optimal method for estimating glomerular filtration rate (eGFR). METHODS: Surgical approach, adjuvant therapy, and pathology reports were reviewed for patients with at least six months follow-up from definitive surgery. eGFRs, as assessed by the Schwartz and Chronic Kidney Disease in Children (CKiD) formulas, were compared to measured GFR (mGFR) determined by (99m)Tc-DTPA scanning...
October 27, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27845967/what-is-new-in-pediatric-surgical-oncology
#3
Roshni Dasgupta, Deborah Billmire, Jennifer H Aldrink, Rebecka L Meyers
PURPOSE OF REVIEW: As pediatric oncology has become more complex, designing and maintaining pediatric surgical protocols require greater expertise. The primary purpose of this review is to summarize the changes in protocols and new study findings, which have changed surgical practice for children with solid tumors. RECENT FINDINGS: The most common solid tumors treated by surgery are reviewed. There are new methods of surgical techniques such as the use of sentinel lymph node techniques for the assessment of lymph nodes in pediatric sarcoma...
November 14, 2016: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/27820132/renal-tumors-in-children-younger-than-12-months-of-age-a-65-year-single-institution-review
#4
Margaret G Lamb, Jennifer H Aldrink, Sarah H O'Brien, Han Yin, Michael A Arnold, Mark A Ranalli
Wilms tumor (WT) is the most prevalent pediatric renal tumor and most commonly occurs between ages 1 and 5 years. Data are lacking on children younger than 12 months with renal tumors. The cancer registry at the authors' institution was queried to identify patients 12 months and younger with renal masses. Demographics, clinical presentation, histopathology, stage, and survival outcomes were reviewed. The most common presenting symptoms included an asymptomatic abdominal mass (73%) and hematuria (9%). Histopathology revealed WT in 73% of patients, mesoblastic nephroma in 20%...
November 4, 2016: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27811504/clinical-outcome-and-biological-predictors-of-relapse-after-nephrectomy-only-for-very-low-risk-wilms-tumor-a-report-from-children-s-oncology-group-aren0532
#5
Conrad V Fernandez, Elizabeth J Perlman, Elizabeth A Mullen, Yueh-Yun Chi, Thomas E Hamilton, Kenneth W Gow, Fernando A Ferrer, Douglas C Barnhart, Peter F Ehrlich, Geetika Khanna, John A Kalapurakal, Tina Bocking, Vicky Huff, Jing Tian, James I Geller, Paul E Grundy, James R Anderson, Jeffrey S Dome, Robert C Shamberger
OBJECTIVE: To determine if observation alone after nephrectomy in very low-risk Wilms tumor (defined as stage I favorable histology Wilms tumors with nephrectomy weight <550g and age at diagnosis <2 years) results in satisfactory event-free survival and overall survival, and to correlate relapse with biomarkers. PATIENTS AND METHODS: The AREN0532 study enrolled patients with very low-risk Wilms tumor confirmed by central review of pathology, diagnostic imaging, and surgical reports...
March 16, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27807337/-giant-solitary-fibrous-tumor-of-the-pleura-a-case-report-and-literature-review
#6
Guangyan Xu, Jianyong Zhang
Solitary fibrous tumor (SFT) is a derived mesenchymal tumor from spindle cells, mostly occurred in the pleura. To analyze the clinical features of the SFT, data for a patient with SFT that involved in the pleura were retrospectively analyzed by assisted thoracoscope in the Affiliated Hospital of Zunyi Medical College in August 2015. The male patient was 45 years old, who showed the main clinical symptoms of chest pain, cough, sputum, and dyspnea. Large amount of right pleural effusion, chest space-occupying lesions were found by chest CT, suggesting a malignant tumor with metastasis at the 2nd and 3rd right rib...
October 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/27803953/predictive-factor-for-intraoperative-tumor-rupture-of-wilms-tumor
#7
Hiroaki Fukuzawa, Yuko Shiima, Yasuhiko Mishima, Sachi Sekine, Shizu Miura, Kiyoaki Yabe, Satoshi Yamaki, Keiichi Morita, Yuichi Okata, Chieko Hisamatsu, Makoto Nakao, Akiko Yokoi, Kosaku Maeda, Yoshiyuki Kosaka
PURPOSE: For Wilms tumor, intraoperative tumor rupture with wide tumor spillage during surgical manipulation raises the classification to stage 3. Then, postoperative chemotherapy must be more intensive, and abdominal radiotherapy is added. Therefore, intraoperative tumor rupture should be avoided if possible. However, predictive factors for intraoperative tumor rupture have not been sufficiently described. Here we examined the risk factors for intraoperative tumor rupture. METHODS: Patients with Wilms tumor who underwent treatment according to the National Wilms Tumor Study or the Japanese Wilms Tumor Study protocol at our institution were reviewed retrospectively...
November 1, 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/27720972/-zero-ischemia-laparoscopic-assisted-partial-nephrectomy-for-the-management-of-selected-children-with-wilms-tumors-following-neoadjuvant-chemotherapy
#8
Roberto Iglesias Lopes, Jessica Ming, Martin A Koyle, Ronald Grant, Adriana Fonseca, Armando J Lorenzo
OBJECTIVE: To describe the experience and technique of zero-ischemia laparoscopic-assisted partial nephrectomy at The Hospital for Sick Children, as an alternative to the traditional open approach for nephron sparing surgery in selected children with Wilms' tumors (WT). MATERIALS AND METHODS: Patients with diagnosis of WT treated with neoadjuvant chemotherapy and who underwent laparoscopic-assisted nephron-sparing surgery at the Hospital for Sick Children from 2012-2016 were identified and charts reviewed retrospectively...
October 6, 2016: Urology
https://www.readbyqxmd.com/read/27702824/significance-of-tp53-mutation-in-wilms-tumors-with-diffuse-anaplasia-a-report-from-the-children-s-oncology-group
#9
Ariadne H A G Ooms, Samantha Gadd, Daniela S Gerhard, Malcolm A Smith, Jaime M Guidry Auvil, Daoud Meerzaman, Qing-Rong Chen, Chih Hao Hsu, Chunhua Yan, Cu Nguyen, Ying Hu, Yussanne Ma, Zusheng Zong, Andrew J Mungall, Richard A Moore, Marco A Marra, Vicki Huff, Jeffrey S Dome, Yueh-Yun Chi, Jing Tian, James I Geller, Charles G Mullighan, Jing Ma, David A Wheeler, Oliver A Hampton, Amy L Walz, Marry M van den Heuvel-Eibrink, Ronald R de Krijger, Nicole Ross, Julie M Gastier-Foster, Elizabeth J Perlman
PURPOSE: To investigate the role and significance of TP53 mutation in diffusely anaplastic Wilms tumors (DAWTs). EXPERIMENTAL DESIGN: All DAWTs registered on National Wilms Tumor Study-5 (n = 118) with available samples were analyzed for TP53 mutations and copy loss. Integrative genomic analysis was performed on 39 selected DAWTs. RESULTS: Following analysis of a single random sample, 57 DAWTs (48%) demonstrated TP53 mutations, 13 (11%) copy loss without mutation, and 48 (41%) lacked both [defined as TP53-wild-type (wt)]...
October 4, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27575645/ossifying-renal-tumor-of-infancy-report-of-a-case-with-positive-wt-1-immunohistochemistry-and-high-mitotic-index-and-review-of-the-literature
#10
Benoit Vaillancourt, Luc Laurier Oligny, Julie Déry, Julie Franc-Guimond, Dorothee Bouron-Dal Soglio
Ossifying renal tumor of infancy (ORTI) is a rare, benign pediatric tumor of the kidney. Since first reported by Chatten in 1980, 23 cases have been published. Previous authors have argued that ORTI might originate from nephrogenic rests, thereby sharing a pathogenic relationship with Wilms' tumor (WT). ORTI is characterized histologically by a population of polygonal osteoblast-like cells around an osteoid core and densely cellular component of blastemal-like or spindle cells. While the immunohistochemical profile of the cellular components has been reported, to the best of our knowledge the status of WT1 expression has only been reported once, where it showed negative marking...
August 30, 2016: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/27565764/pencil-beam-scanning-proton-therapy-for-treatment-of-the-retroperitoneum-after-nephrectomy-for-wilms-tumor-a-dosimetric-comparison-study
#11
Jennifer Vogel, Haibo Lin, Stefan Both, Zelig Tochner, Frank Balis, Christine Hill-Kayser
BACKGROUND: Multimodality treatment for patients with Wilms tumor has improved patient survival, but is associated with acute and long-term toxicity, partially due to irradiation. Proton therapy using pencil beam scanning (PBS) is a promising technique to reduce dose to organs at risk (OAR). In this study, we evaluate PBS plans for postoperative irradiation in patients with Wilms tumor. PROCEDURE: Patients were treated with anterior-posterior-posterior-anterior (AP-PA) photon fields encompassing the preoperative tumor volume...
August 27, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27444278/functional-and-clinical-significance-of-sall4-in-breast-cancer
#12
Ebubekir Dirican, Mustafa Akkiprik
The gene encoding Sal-like 4 (Drosophila) (SALL4) is a zinc-finger transcriptional factor and a vertebrate orthologous of the Drosophila gene spalt (sal), which is upregulated in some cancers. SALL4 is expressed in the early developmental stages of Drosophila. Moreover, murine SALL4 plays a vital role in protecting the properties of embryonic stem (ES) cells and guiding the outcome of the primal inner cell mass by interacting with OCT4 and NANOG. SALL4 in ES cells and tumor cells is known as a regulator for controlling cell growth, proliferation, and apoptosis...
July 21, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27417957/the-role-of-wt1-in-embryonic-development-and-normal-organ-homeostasis
#13
Bettina Wilm, Ramon Muñoz-Chapuli
The Wilms' tumor suppressor gene 1 (Wt1) is critically involved in a number of developmental processes in vertebrates, including cell differentiation, control of the epithelial/mesenchymal phenotype, proliferation, and apoptosis. Wt1 proteins act as transcriptional and post-transcriptional regulators, in mRNA splicing and in protein-protein interactions. Furthermore, Wt1 is involved in adult tissue homeostasis, kidney function, and cancer. For these reasons, Wt1 function has been extensively studied in a number of animal models to establish its spatiotemporal expression pattern and the developmental fate of the cells expressing this gene...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27372391/cancer-risk-in-beckwith-wiedemann-syndrome-a-systematic-review-and-meta-analysis-outlining-a-novel-epi-genotype-specific-histotype-targeted-screening-protocol
#14
Alessandro Mussa, Cristina Molinatto, Giuseppina Baldassarre, Evelise Riberi, Silvia Russo, Lidia Larizza, Andrea Riccio, Giovanni Battista Ferrero
OBJECTIVE: To compare tumor risk in the 4 Beckwith-Wiedemann syndrome (BWS) molecular subgroups: Imprinting Control Region 1 Gain of Methylation (ICR1-GoM), Imprinting Control Region 2 Loss of Methylation (ICR2-LoM), Chromosome 11p15 Paternal Uniparental Disomy (UPD), and Cyclin-Dependent Kinase Inhibitor 1C gene (CDKN1C) mutation. STUDY DESIGN: Studies on BWS and tumor development published between 2000 and 2015 providing (epi)genotype-cancer correlations with histotype data were reviewed and meta-analysed with cancer histotypes as measured outcome and (epi)genotype as exposure...
September 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27313862/wilms-tumor-in-a-51-year-old-patient-an-extremely-rare-case-and-review-of-the-literature
#15
Jia Hu, L U Jin, Tao He, Yifan Li, Yang Zhao, Y U Ding, Xianxin Li, Yunchu Liu, Yaoting Gui, Xiangming Mao, Yongqing Lai, Liangchao Ni
Wilms tumor or nephroblastoma is a common kidney malignant tumor in childhood, accounting for ~5% of all pediatric tumors. At present, reports on Wilms' tumor occurring in adults, particularly at ages >30 years, are extremely rare. The majority of the cases of adult Wilms' tumor are closely associated with chemotherapy. Furthermore, in rare cases, Wilms' tumor is characterized by three classic types of cells, namely blastemal, stromal and epithelial cells. We herein report a case of Wilms' tumor with three classic types of cells on histological examination in a 51 year-old male patient who had received prior chemotherapy...
June 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27276240/renal-leiomyoma-and-leiomyosarcoma-a-study-of-57-cases
#16
Sounak Gupta, Rafael E Jimenez, Andrew L Folpe, John C Cheville
Primary renal leiomyomas and leiomyosarcomas are rare, and there is a paucity of data regarding the pathologic features and outcomes of patients with these tumors. The objective of this study was to review a large series of renal smooth muscle tumors, in order to more fully elucidate their natural histories. Fifty-seven renal smooth muscle tumors were reviewed for various histopathologic features, and leiomyosarcomas were graded using the French Federation of Cancer Centers (FNCLCC) system. Tumor cores in tissue microarrays were evaluated for smooth muscle actin, desmin, h-caldesmon, calponin, myogenin, cytokeratin (OSCAR), CD117, Ki67, estrogen receptor (ER), progesterone receptor (PR), and Wilms tumor 1 (WT1)...
June 7, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27259655/biomarkers-for-wilms-tumor-a-systematic-review
#17
Eugene B Cone, Stewart S Dalton, Megan Van Noord, Elizabeth T Tracy, Henry E Rice, Jonathan C Routh
PURPOSE: Wilms tumor is the most common childhood renal malignancy and the fourth most common childhood cancer. Many biomarkers have been studied but there has been no comprehensive summary. We systematically reviewed the literature on biomarkers in Wilms tumor to quantify the prognostic implications of the presence of individual tumor markers. MATERIALS AND METHODS: We searched for English language studies from 1980 to 2015 performed in patients younger than 18 years with Wilms tumor and prognostic data...
November 2016: Journal of Urology
https://www.readbyqxmd.com/read/27252512/wilms-tumor-1-mutations-in-the-pathogenesis-of-acute-myeloid-leukemia
#18
REVIEW
Raajit Rampal, Maria E Figueroa
Wilms tumor 1 (WT1) has long been implicated in acute myeloid leukemia. It has been described to be both overexpressed and mutated in different forms of acute myeloid leukemia, and overexpression has been reported to play a prognostic role in this disease. However, the precise mechanism through which WT1 may play a role in leukemogenesis has remained elusive. In recent years, new evidence has emerged that points towards a novel role of WT1 mutations in the deregulation of epigenetic programs in leukemic cells through its interaction with TET proteins...
June 2016: Haematologica
https://www.readbyqxmd.com/read/27228957/is-nephron-sparing-surgery-justified-in-wilms-tumor-with-beckwith-wiedemann-syndrome-or-isolated-hemihypertrophy
#19
Aurélien Scalabre, Christophe Bergeron, Frederic Brioude, Linda Dainese, Claire Cropet, Aurore Coulomb L'hermine, Claudia Pasqualini, Frederic Auber, Arnauld Verschuur, Gudrun Schleiermacher, Yves Le Bouc, Georges Audry, Sabine Irtan
BACKGROUND: Patients with Beckwith-Wiedemann syndrome (BWS) or isolated hemihypertrophy (HH) treated for a Wilms tumor (WT) carry an increased risk of developing metachronous lesion. There are no guidelines on precise indications for nephron sparing surgery (NSS) in unilateral WT (UWT). The objective of this retrospective study was to delineate the indications of NSS in patients with BWS/HH treated for WT and to evaluate their outcome. PROCEDURE: All cases of BWS/HH treated for a WT according to SIOP protocols from 1980 to 2013 were reviewed...
September 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27227914/the-clinical-characteristics-of-metanephric-adenoma-a-case-report-and-literature-review
#20
Hua Fan, Qian-Qian Shao, Han-Zhong Li, Yu Xiao, Yu-Shi Zhang
We describe the clinical presentation, diagnosis, treatment, and follow-up data of a 39-year-old woman with asymptomatic right kidney tumor, which was later histopathologically diagnosed as metanephric adenoma (MA). Macroscopically, the tumor had integrity tegument with homogeneous and gray cutting surface. Microscopically, the tumor cells were formed in adenoid or papillary pattern and contained psammoma bodies, without distinctive atypia. Immunohistochemistry results showed they were negative for creatine kinase 7, epithelial membrane antigen, and renal cell carcinoma, and positive for AE1/AE3, vimentin, and Wilms Tumor 1...
May 2016: Medicine (Baltimore)
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