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https://www.readbyqxmd.com/read/30025233/pets-enhance-antidepressant-pharmacotherapy-effects-in-patients-with-treatment-resistant-major-depressive-disorder
#1
Jorge Mota Pereira, Daniela Fonte
Treatment resistant major depressive disorder (TR-MDD) is a severe disease, with very low remission rates. The resistance to pharmacotherapy leads to the search of non-pharmacological alternative approaches. Animal therapy has been used in patients with psychiatric conditions and the results have been promising. However, there have been no studies in TR-MDD patients with pet adoption. This study assessed the impact of TR-MDD patients adopting a pet. Eighty patients were suggested to adopt a pet, and 33 accepted the challenge...
July 11, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/30023832/salts-of-amoxapine-with-improved-solubility-for-enhanced-pharmaceutical-applicability
#2
Mayank Joshi, Angshuman Roy Choudhury
The objective of pharmaceutical cocrystallization is to create crystalline analogues that have vastly different properties, such as solubility, melting point, stability, and bioavailability from that observed in the pure active pharmaceutical ingredients (APIs). Amoxapine is a benzoxazepine derivative and exhibits antidepressant properties. Amoxapine has very low solubility in water, so it was cocrystallized with natural acids in a 1:1 ratio in appropriate solvents by the solvent-drop grinding method. Single crystals of cocrystals were grown by the solvent evaporation method in water, ethanol, and methanol...
February 28, 2018: ACS Omega
https://www.readbyqxmd.com/read/30023338/erratum-to-chirality-of-modern-antidepressants-an-overview
#3
Monica Budău, Gabriel Hancu, Aura Rusu, Melania Cârcu-Dobrin, Daniela Lucia Muntean
[This corrects the article DOI: 10.15171/apb.2017.061.].
June 2018: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/30023078/rational-antidepressant-use
#4
Daniel Dunleavy
No abstract text is available yet for this article.
June 2018: BJPsych Bulletin
https://www.readbyqxmd.com/read/30022871/-radix-polygalae-extract-attenuates-ptsd-like-symptoms-in-a-mouse-model-of-single-prolonged-stress-and-conditioned-fear-possibly-by-reversing-bag1
#5
Ju-Yeon Shin, Jung-Won Shin, Sang-Kyu Ha, Yoorim Kim, Kelley M Swanberg, Suck Lee, Tae-Woo Kim, Sungho Maeng
Radix Polygalae (RP) has been used to relieve psychological stress in traditional oriental medicine. Recently, cell protective, antiamnestic and antidepressant-like effects were disclosed but the possible application of RP to post-traumatic stress disorder, in which exaggerated fear memory persists, has not yet been explored. For this purpose, the effects of RP on fear behavior was examined in a mouse model of single prolonged stress and conditioned fear (SPS-CF), previously shown to mimic key symptoms of post-traumatic stress disorder...
June 2018: Experimental Neurobiology
https://www.readbyqxmd.com/read/30022870/antidepressant-like-effects-of-p-coumaric-acid-on-lps-induced-depressive-and-inflammatory-changes-in-rats
#6
Seok Lee, Hyun-Bum Kim, Eun-Sang Hwang, Eun-Seok Kim, Sung-Soo Kim, Tae-Dong Jeon, Min-Cheol Song, Ji-Seung Lee, Min-Chan Chung, Sungho Maeng, Ji-Ho Park
Depression causes mental and physical changes which affect quality of life. It is estimated to become the second most prevalent disease, but despite its commonness, the pathophysiology of depression remains unclear and medicine is not sufficiently protective. p-Coumaric acid (p-CA) is a dietary phenolic acid which has been proven to have antifungal, anti-HIV, anti-melanogenic, antioxidant and anti-inflammatory effects. Considering these effects, we investigated whether p-CA can prevent depressive symptoms by reducing inflammatory cytokines in animals injected with lipopolysaccharide (LPS)...
June 2018: Experimental Neurobiology
https://www.readbyqxmd.com/read/30022437/role-of-a-vgf-bdnf-trkb-autoregulatory-feedback-loop-in-rapid-acting-antidepressant-efficacy
#7
Cheng Jiang, Wei-Jye Lin, Stephen R Salton
Members of the neurotrophin family and in particular brain-derived neurotrophic factor (BDNF) regulate the response to rapid- and slow-acting chemical antidepressants and voluntary exercise. Recent work suggests that rapid-acting antidepressants that modulate N-methyl-D-aspartate receptor (NMDA-R) signaling (e.g., ketamine and GLYX-13) require expression of VGF (non-acronymic), the BDNF-inducible secreted neuronal protein and peptide precursor, for efficacy. In addition, the VGF-derived C-terminal peptide TLQP-62 (named by its 4 N-terminal amino acids and length) has antidepressant efficacy following icv or intra-hippocampal administration, in the forced swim test (FST)...
July 18, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/30022062/regulation-of-monoamine-transporters-and-receptors-by-lipid-microdomains-implications-for-depression
#8
REVIEW
Joanne J Liu, Adrienne Hezghia, Saame Raza Shaikh, Joshua F Cenido, Ruth E Stark, J John Mann, M Elizabeth Sublette
Lipid microdomains ("rafts") are dynamic, nanoscale regions of the plasma membrane enriched in cholesterol and glycosphingolipids, that possess distinctive physicochemical properties including higher order than the surrounding membrane. Lipid microdomain integrity is thought to affect neurotransmitter signaling by regulating membrane-bound protein signaling. Among the proteins potentially affected are monoaminergic receptors and transporters. As dysfunction of monoaminergic neurotransmission is implicated in major depressive disorder and other neuropsychiatric conditions, interactions with lipid microdomains may be of clinical importance...
June 28, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30020573/-new-indications-for-existing-drugs-repurposing-in-psychiatry-and-addiction-medicine
#9
Jurriaan F M Strous, Wim van den Brink
Repurposing is the discovery - whether or not by accident - of a new use for an existing product, for example, a new indication for a drug. In the past, several psychotropic drugs have received their place in the treatment arsenal via this route. Both in psychiatry and addiction medicine, there is an important need for new treatments with new working mechanisms. Potential new uses in both psychiatry and addiction medicine of several drugs that have already been registered for other indications are currently under study...
May 2, 2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/30019267/antidepressant-like-action-of-agmatine-in-the-acute-and-sub-acute-mouse-models-of-depression-a-receptor-mechanism-study
#10
Zhao-Di Chen, Wen-Qiang Chen, Zhi-Yuan Wang, Dan-Ni Cao, Ning Wu, Jin Li
Previous studies have shown that agmatine, a potential neuromodulator or co-transmitter, exhibited antidepressant-like action in animal models, yet its mechanism, especially the receptor mechanism, remains unclear. In the present study, using efaroxan, a preferential antagonist of I1 imidazoline receptor (I1 R) and yohimbine, an antagonist of α2 adrenergic receptor (α2 AR), we investigated the roles of I1 R and α2 AR in agmatine's antidepressant-like effect in acute and sub-acute depression models in mice...
July 17, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/30019210/brain-serotonin-critically-contributes-to-the-biological-effects-of-electroconvulsive-seizures
#11
Golo Kronenberg, Markus Petermann, Christof Dormann, Michael Bader, Peter Gass, Rainer Hellweg, Friederike Klempin
Compounds targeting serotonin (5-HT) are widely used as antidepressants. However, the role of 5-HT in mediating the effects of electroconvulsive seizure (ECS) therapy remains undefined. Using Tph2-/- mice depleted of brain 5-HT, we studied the effects of ECS on behavior and neurobiology. ECS significantly prolonged the start latency in the elevated O-Maze test, an effect that was abolished in Tph2-/- mice. Furthermore, in the absence of 5-HT, the ECS-induced increase in adult neurogenesis and in brain-derived neurotrophic factor signaling in the hippocampus were significantly reduced...
July 17, 2018: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/30018804/depression-as-a-risk-factor-for-the-development-of-rheumatoid-arthritis-a-population-based-cohort-study
#12
Isabelle A Vallerand, Ryan T Lewinson, Alexandra D Frolkis, Mark W Lowerison, Gilaad G Kaplan, Mark G Swain, Andrew G M Bulloch, Scott B Patten, Cheryl Barnabe
Objectives: Major depressive disorder (MDD) is associated with increased levels of systemic proinflammatory cytokines, including tumour necrosis factor alpha. As these cytokines are pathogenic in autoimmune diseases such as rheumatoid arthritis (RA), our aim was to explore on a population-level whether MDD increases the risk of developing RA. Methods: A retrospective cohort study was conducted using The Health Improvement Network (THIN) database (from 1986 to 2012)...
2018: RMD Open
https://www.readbyqxmd.com/read/30018196/temporal-profiles-and-dose-responsiveness-of-side-effects-with-escitalopram-and-duloxetine-in-treatment-na%C3%A3-ve-depressed-adults
#13
Philip E Polychroniou, Helen S Mayberg, W Edward Craighead, Jeffrey J Rakofsky, Vivianne Aponte Rivera, Ebrahim Haroon, Boadie W Dunlop
Side effect profiles of antidepressants are relevant to treatment selection and adherence among patients with major depressive disorder (MDD), but several clinically-relevant characteristics of side effects are poorly understood. We aimed to compare the side effect profiles of escitalopram and duloxetine, including frequencies, time to onset, duration, dose responsiveness, and impact on treatment outcomes. Side effects occurring in 211 treatment-naïve patients with MDD randomized to 12 weeks of treatment with flexibly-dosed escitalopram (10⁻20 mg/day) or duloxetine (30⁻60 mg/day) as part of the Predictors of Remission in Depression to Individual and Combined Treatments (PReDICT) study were evaluated...
July 17, 2018: Behavioral Sciences
https://www.readbyqxmd.com/read/30018016/effects-of-the-antidepressant-fluoxetine-on-the-somatostatin-interneurons-in-the-basolateral-amygdala
#14
Hector Carceller, Marta Perez-Rando, Eero Castren, Juan Nacher, Ramon Guirado
Although the precise mechanism of action of antidepressant drugs remains elusive, the neuroplastic hypothesis has gained acceptance during the last two decades. Several studies have shown that treatment with antidepressants such as Fluoxetine is associated with enhanced plasticity in control animals, especially in regions such as the visual cortex, the hippocampus and the medial prefrontal cortex. More recently, the basolateral amygdala has been shown to be affected by Fluoxetine leading to a reopening of critical period-like plasticity in the fear and aggression circuits...
July 4, 2018: Neuroscience
https://www.readbyqxmd.com/read/30017780/carbamoylated-erythropoietin-induces-a-neurotrophic-gene-profile-in-neuronal-cells
#15
Neeraj K Tiwari, Monica Sathyanesan, William Schweinle, Samuel S Newton
Erythropoietin (EPO), a cytokine molecule, is best-known for its role in erythropoiesis. Preclinical studies have demonstrated that EPO has robust neuroprotective effects that appear to be independent of erythropoiesis. It is also being clinically tested for the treatment of neuropsychiatric illnesses due to its behavioral actions. A major limitation of EPO is that long-term administration results in excessive red blood cell production and increased blood viscosity. A chemical modification of EPO, carbamoylated erythropoietin (CEPO), reproduces the behavioral response of EPO in animal models but does not stimulate erythropoiesis...
July 11, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/30017777/differential-effects-of-citalopram-on-sleep-deprivation-induced-depressive-like-behavior-and-memory-impairments-in-mice
#16
Afzal Misrani, Sidra Tabassum, Xi Chen, Shu-Yi Tan, Ji-Chen Wang, Li Yang, Cheng Long
Recently there is increasing concern over the association between sleep deprivation (S-Dep) and depression. Mounting evidence suggests that S-Dep might be a risk factor for depression. However, underlying molecular mechanism remains elusive and currently there is no effective therapy to negate the effects of S-Dep. In this study, we aimed to examine whether subchronic treatment of citalopram (CTM), an antidepressant, can attenuate the negative effects of S-Dep in mice. Three-month-old C57BL/6J mice were divided into control, S-Dep, CTM control and CTM + S-Dep groups...
July 12, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/30017640/naringenin-protects-against-oxido-inflammatory-aberrations-and-altered-tryptophan-metabolism-in-olfactory-bulbectomized-mice-model-of-depression
#17
Yashika Bansal, Raghunath Singh, Priyanka Saroj, Rupinder Kaur Sodhi, Anurag Kuhad
Oxido-inflammatory aberrations play a substantial role in the pathophysiology of depression. Oxido-inflammatory stress increases catabolism of tryptophan into kynurenine which leads to imbalance in kynurenine and serotonin levels in the brain. Naringenin a flavonoid, has been reported to possess antidepressant property by restoring serotonin and noradrenaline levels in the brain. Its effects on oxido-inflammatory aberrations in depression has not been investigated. With this background, the present study was designed to investigate the antidepressant-like potential of naringenin in olfactory bulbectomy (OBX)-induced neuroinflammation, oxidative stress, altered kynurenine pathway, and behavioural deficits in BALB/C mice...
July 11, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/30017260/abnormal-serum-potassium-levels-and-6-month-all-cause-mortality-in-patients-co-treated-with-antipsychotic-and-diuretic-drugs-a-danish-register-based-cohort-study
#18
Mette Marcussen, Christoffer Polcwiartek, Elisabeth Helen Anna Mills, Fia Jirback, Pernille Bylin, Christian Torp-Pedersen, Peter Søgaard, Kristian Kragholm
Psychiatric patients have excess mortality compared to the general population, and several potential mechanisms may explain this increased risk. This study examined the relationship between serum potassium levels and risk of all-cause mortality in patients co-treated with antipsychotic and diuretic drugs. Using a register-based cohort design, we identified patients between 1995 and 2012 who received a combination of an antipsychotic and a diuretic drug and who further had a serum potassium measurement within 90 days...
July 14, 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/30016772/withdrawal-symptoms-after-serotonin-noradrenaline-reuptake-inhibitor-discontinuation-systematic-review
#19
Giovanni A Fava, Giada Benasi, Marcella Lucente, Emanuela Offidani, Fiammetta Cosci, Jenny Guidi
BACKGROUND: Serotonin-noradrenaline reuptake inhibitors (SNRI) are widely used in medical practice. Their discontinuation has been associated with a wide range of symptoms. The aim of this paper is to identify the occurrence, frequency, and features of withdrawal symptoms after SNRI discontinuation. METHODS: PRISMA guidelines were followed to conduct a systematic review. Electronic databases included PubMed, the Cochrane Library, Web of Science, and MEDLINE from the inception of each database to June 2017...
July 17, 2018: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/30016730/%C3%AE-phenylselanyl-acetophenone-mitigates-reserpine-induced-pain-depression-dyad-behavioral-biochemical-and-molecular-docking-evidences
#20
Fernanda Severo Sabedra Sousa, Paloma Taborda Birmann, Rodolfo Baldinotti, Mariana G Fronza, Renata Balaguez, Diego Alves, César Augusto Brüning, Lucielli Savegnago
Chronic pain and depressive disorders have been estimated to co-occur in up to 80% of patients and traditional antidepressants and analgesics have shown limited clinical efficacy. α- (phenylselanyl) acetophenone (PSAP) is an organic selenium compound which has already demonstrated antioxidant, antidepressant and antinociceptive activities in animal models, without showing acute toxicity. In view of develop more effective treatments to comorbid pain and depression, the purpose of this study was to evaluate the behavioral and biochemical effects of PSAP on reserpine induced pain-depression dyad model in mice as well to analyze the interaction of PSAP with specific targets by molecular docking analysis...
July 14, 2018: Brain Research Bulletin
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