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Hepatits E virus

Juan Berenguer, Inmaculada Jarrín, Leire Pérez-Latorre, Víctor Hontañón, María J Vivancos, Jordi Navarro, María J Téllez, Josep M Guardiola, José A Iribarren, Antonio Rivero-Juárez, Manuel Márquez, Arturo Artero, Luis Morano, Ignacio Santos, Javier Moreno, María C Fariñas, María J Galindo, María A Hernando, Marta Montero, Carmen Cifuentes, Pere Domingo, José Sanz, Lourdes Domíngez, Oscar L Ferrero, Belén De la Fuente, Carmen Rodríguez, Sergio Reus, José Hernández-Quero, Gabriel Gaspar, Laura Pérez-Martínez, Coral García, Lluis Force, Sergio Veloso, Juan E Losa, Josep Vilaró, Enrique Bernal, Sari Arponen, Amat J Ortí, Ángel Chocarro, Ramón Teira, Gerardo Alonso, Rafael Silvariño, Ana Vegas, Paloma Geijo, Josep Bisbe, Herminia Esteban, Juan González-García
Background: We assessed the prevalence of antibodies against hepatitis C virus (HCV-Abs) and active HCV infection in patients infected with human immunodeficiency virus (HIV) in Spain in 2016 and compared the results with those of similar studies performed in 2002, 2009, and 2015. Methods: The study was performed in 43 centers during October-November 2016. The sample was estimated for an accuracy of 2% and selected by proportional allocation and simple random sampling...
January 2018: Open Forum Infectious Diseases
Grazia Tosone, Davide Simeone, Anna M Spera, Giulio Viceconte, Vincenzo Bianco, Raffaele Orlando
The pregnancy-associated immunological and hormonal changes may alter the immune response to infectious agents, including hepatitis viruses. Therefore, this phenomenon may affect the clinical course and the outcome of acute viral hepatitis in pregnant women. For this reason, we have focused on epidemiological and pathogenetic aspects of the fulminant liver failure caused by acute viral hepatitis reviewing PubMED in April of 2017. Although all the viruses might cause a fulminant AVH in a pregnant woman, the large majority of fulminant failure reported in the literature had been related to Hepatits E Virus mainly and had been concentrated in Indian subcontinent and some African areas, whereas the problem seems to be very low or absent in the remaining geographical areas...
October 9, 2017: Minerva Ginecologica
Marcelo Siqueira de Oliveira, Romeu Paulo Martins Silva, Suiane da Costa Negreiros do Valle, Elisabeth Níglio de Figueiredo, Dayana Fram
Objective: compare chronic hepatitis B patients to those superinfected with hepatitis D virus, according to Child-Pugh score regarding disease severity. Method: retrospective descriptive study, performed with 59 patients followed in the ambulatory, of which 22 (37.3%) were chronically infected with hepatitis B virus (Group HBV) and 37 (62.7%) superinfected with Delta virus (Group HBV+HDV); variables of sex, age and items of Child-Pugh score were collected by consulting medical records...
September 2017: Revista Brasileira de Enfermagem
Tarcila Maria Bonfim Ferreira, Tácio Giordano Santana Guimarães, Andrea Martins Melo Fontenele, Natalino Salgado, Adalgisa de Souza Paiva Ferreira, Alessandra Porto de Macedo Costa
INTRODUCTION: Vaccination is the most effective tool in preventing transmission of Hepatitis B Virus (HBV). The patient with chronic kidney disease (CKD) on dialysis appear to be at greater risk of becoming infected with this virus and does not show the same vaccine response when compared to patients without uremia. OBJECTIVES: To evaluate the results related to the HBV vaccine and identify factors associated with the response in patients with CKD on hemodialysis...
April 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Gülsüm İclal Bayhan, Kaan Demiören, Hüseyin Güdücüoğlu
AIM: Hepatitis E virus is an etiological agent of hepatitis which is transmitted enterically and may lead to water-born outbreaks. Although it is mainly transmitted by the fecal-oral route, it is estimated that many cases are associated with zoonotic transmission in developing countries. In this study, we aimed to investigate the seroprevalence of hepatitis E in the childhood age group in the province of Van and to demonstrate the relationship between seroprevalence and demographic properties, residential house/region, water supply used at home, dealing with livestock and history of surgery...
September 2016: Türk Pediatri Arşivi
L Michel, C Lions, M Winnock, J-P Lang, M-A Loko, E Rosenthal, B Marchou, M-A Valantin, P Morlat, P Roux, P Sogni, B Spire, I Poizot-Martin, K Lacombe, C Lascoux-Combe, C Duvivier, D Neau, F Dabis, D Salmon-Ceron, M P Carrieri
OBJECTIVES: The objective of this nested study was to assess the prevalence of psychiatric disorders in a sample of HIV/hepatitis C virus (HCV)-coinfected patients according to their HCV status. METHODS: The nested cross-sectional study, untitled HEPAVIH-Psy survey, was performed in a subset of HIV/HCV-coinfected patients enrolled in the French Agence Nationale de Recherche sur le SIDA et les Hépatites Virales (ANRS) CO13 HEPAVIH cohort. Psychiatric disorders were screened for using the Mini International Neuropsychiatric Interview (MINI 5...
November 2016: HIV Medicine
Temitope Oluwasegun Cephas Faleye, Olubusuyi Moses Adewumi, Ijeoma Maryjoy Ifeorah, Adegboyega Akere, Adeleye Solomon Bakarey, Ewean Chukwuma Omoruyi, Kemi Oketunde, Oluwajumoke Bosede Awonusi, Modupe Racheal Ajayi, Johnson Adekunle Adeniji
BACKGROUND: In 2012, the first Nigerian Hepatitis B Virus (HBV) immune escape mutant (IEM) case was detected in a pregnant woman in southwestern Nigeria. Consequently, this study was designed to investigate the presence and possible circulation of IEMs amongst asymptomatic community dwellers in southwestern Nigeria. METHODS: Blood specimens collected from 438 asymptomatic community dwellers were screened for HBsAg using ELISA technique. Subsequently, the S-gene was amplified in HBsAg positive samples by a nested PCR protocol, and amplicons sequenced...
October 2015: International Journal of Infectious Diseases: IJID
S Fabiani
Interferon (IFN)-inducible protein-10 (IP-10) is a proinflammatory chemokine, binding the chemokine (C-X-C motif) receptor 3 (CXCR3), which is found mainly on activated T cells and natural killer (NK) cells, and plays an important role in T helper (Th) 1 type inflammatory disorders (autoimmune, neoplastic, and infectious diseases). Concerning viral hepatitis, IP-10 appears to be involved on the pathogenesis of liver damage as well as on the extra-hepatic manifestations either protecting or promoting infection, depending on host immune status and genetic background...
2015: La Clinica Terapeutica
Xiang-Yong Li, Xu You, Yu-Sheng Jie, Guo-Li Lin, Yuan-Kai Wu, Ming-Xing Huang, Min Zhang, Zhan-Yi Li, Dong-Ying Xie, Zhi-Liang Gao, Yu-Tian Chong
The aim of this study was to evaluate the efficacy and safety of entecavir (ETV) combined treatment with adefovir (ADV) on chronic hepatitic B (CHB) patients who failed to respond to nucleotide (acid) analog (NA) treatment. On this basis, the possible factors in the combined treatment of these patients will be analyzed. The safety, biochemical index, and the possible factors that might affect the ETV and ADV combined treatment at different points in time were retrospectively analyzed. The biochemical index included the following: virological response, hepatitis B virus (HBV) DNA decline, primary nonresponse, biochemical response, and the hepatitis B virus E antigen/hepatitis B virus E antibody seroconversion rate...
May 2017: American Journal of Therapeutics
T Ozekinci, S Mese, E Ozbek, S Atmaca
BACKGROUND AND AIMS: Chronic hepatitis B is an important health problem worldwide. Lamivudine, adefovir, entecavir and telbivudine are the oral drugs licensed for the treatment of patients with chronic hepatitis B. Implementation of antiviral therapy leads to the emergence of mutant strains during the treatment in chronic hepatitis B. Primary antiviral resistance may be rarely encountered. The aims of this study were to detect the resistance patterns of Hepatit B Virus strains in treatment-naive chronic hepatitis B patients...
2014: La Clinica Terapeutica
Alexandra Ducancelle, Pierre Abgueguen, Jacques Birguel, Wael Mansour, Adeline Pivert, Hélène Le Guillou-Guillemette, Jean-Jacques Sobnangou, Amélie Rameau, Jean-Marie Huraux, Françoise Lunel-Fabiani
BACKGROUND: A program, supported by the GEMHEP (Groupe d'étude Moléculaire des Hépatites), was established in 2007 in the sanitary district of Tokombéré, to prevent perinatal transmission of hepatitis B virus (HBV). It comprises screening for HBV surface antigen (HBsAg) in all pregnant women and vaccinating the newborn if tests are positive. METHODS/PRINCIPAL FINDINGS: 1276 women were enrolled in the study after providing informed consent. Demographic data and blood samples were available for 1267 of the enrolled patients...
2013: PloS One
M L Zubkin, T A Semenenko, F K Kokoeva, V N Borisova, E P Sel'kova, V A Aleshkin
Hepatitis E belongs to the group of enetral hepatites. Its earlier cases caused by genotype I and II viruses were reported largely from epidemics affecting tropical and subtropical countries. Sporadic cases of hepatitis E recorded later in West Europe, North America, Southeast Asia, and Oceania were caused by genotype III and IV viruses. Until recently the disease has been supposed to be reversible and have positive outcome barring women at late stages of pregnancy in whom cases of fulminate clinical course and death were described...
2012: Klinicheskaia Meditsina
Kunio Yano
Hepatitis A and E viruses are spread via the fecal-oral route. In the endemic area, restaurant and school outbreaks due to contaminated water or food have been reported. The clinical signs and symptoms in patients with typical hepatitis A and E are similar to those seen with other forms of acute viral hepatitis. Hepatitis A tends to be more severe when acquired at older ages. Hepatitis E appears to be relatively severe compared with hepatitis A. Although both hepatitis are self-limited illness, severe hepatits are rarely observed...
August 2012: Nihon Rinsho. Japanese Journal of Clinical Medicine
Kushal Naha, Suman Karanth, Mukhyaprana Prabhu, Manpreet Singh Sidhu
We report the case of a young male who presented with features of aseptic meningitis and elevated serum liver enzymes, but no symptoms or signs suggestive of an acute hepatitis. Subsequently, he was diagnosed with dual infection with hepatitis A and E viruses, and recovered completely with symptomatic therapy. Isolated aseptic meningitis, unaccompanied by hepatitic features is an unusual presentation of a hepatotrophic viral infection, and is yet to be reported with hepatitis A and E virus co-infection.
July 2012: Asian Pacific Journal of Tropical Medicine
E Savier, B Granger, F Charlotte, N Cormillot, J M Siksik, J C Vaillant, L Hannoun
BACKGROUND: SCOT 15 is a new solution to preserve abdominal organs for transplantation. Its principal characteristic is the use of polyethylene glycol. Herein We report our experience using SCOT 15 compared with the reference University of Wisconsin (UW) solution for hepatic transplantation. METHODS: We compared 2 groups: SCOT 15 (n = 33; 2009-2010) versus UW (n = 34; 2008-2010), which were paired for cold and warm ischemic times, donor ages, and graft weights. Endpoints were biologic tests in the first 2 months after the operation...
November 2011: Transplantation Proceedings
Yao Lu, Yan-li Zhang, Ge Shen, Lu Zhang, Lin Wang, Guo-hua Qiu, Yun-zhong Wu, Min Yang, Ming-hui Li
OBJECTIVE: To study the clinical features, outcomes and treatments of viral hepatitis combined with aplastic anemia. METHODS: 25 cases diagnosed as viral hepatits combined with aplastic anemia in Beijing Ditan Hsopital between April 2004 and September 2009 were retrospectively analyzed. In this group of patients aplastic anemia was finally diagnosed by bone marrow aspiration. We collected clinical data of these patients, including a history of liver disease, drug allergies, hospital medication history, laboratory data, and then performed descriptive analysis...
August 2011: Chinese Journal of Experimental and Clinical Virology
B Nemes, F Gelley, L Piros, G Zádori, D Görög, I Fehérvári, L Kóbori, E Sárváry, P Nagy, A Kiss, A Doros
In addition to hepatitis C, hepatocellular carcinoma. is a leading indication for orthotopic liver transplantation (OLT). The indications for OLT in HCC remains a topic of debate. The successful Milan criteria are still accepted as the gold standard to select candidates with a good chance for long-term survival. The Hungarian Liver Transplant Program launched in 1995 reached 45 OLT/year in 2010. Among 412 first OLTs, there were 49 cases of a malignant tumor, including 41 among which the indication was the tumor...
May 2011: Transplantation Proceedings
Zhen Xu, Lu-biao Chen, Hong Cao, Xin Shu, Qi-huan Xu, Gang Li, Qi-feng Xie
OBJECTIVE: To investigate the efficacy of the 96-week antiviral therapy with adefovir dipivoxil in patients with chronic hepatitis B. METHODS: 80 patients with chronic hepatitis B received the antiviral therapy of adefovir dipivoxil (ADV, 10 mg/d). At the 12th week, 19 cases without early viral response (EVR, HBV DNA drop < 2 log10copies/ml) switched to the therapy of other nucleoside analogues. Aminotransferase (ALT) normalization, HBV DNA negative, HBeAg loss and HBeAg seroconvertion were accessed at the 96th week...
June 2010: Chinese Journal of Experimental and Clinical Virology
George K K Lau, Nancy Leung
BACKGROUND/AIMS: Clevudine is a pyrimidine analogue with potent activity against hepatitis B virus (HBV) replication in vitro. In a previous pivotal phase III clinical study, 24 weeks treatment with clevudine 30 mg has been shown to profoundly suppress HBV replication and normalize serum alanine aminotransferase level. METHODS: In this study, we compare the efficacy and safety of clevudine (30 mg daily) versus lamivudine (100 mg daily) for 48 weeks in treatment-naive chronic hepatitis B e antigen (HBeAg) positive patients...
September 2010: Korean Journal of Hepatology
V La Fauci, D Sindoni, O C Grillo, S Calimeri, D Lo Giudice, R Squeri
Samples of sewage from treatment plants at the "G. Martino" University Hospital of Messina (AOU) and that of Messina City Council were analysed to detect the hepatits E virus. Samples were taken on sewage entering and exiting the treatment plants on a monthly basis over a one-year period from both the hospital plant (24 samples) and the municipal plant (22 samples). All sewage samples were pretreated by ultrafiltraton and concentration and finally processed by the PCR method to amplify gene material. A total of three samples tested positive: two (8...
March 2010: Journal of Preventive Medicine and Hygiene
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