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Radiculitis

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https://www.readbyqxmd.com/read/28158163/prevalence-of-specific-types-of-pain-diagnoses-in-a-sample-of-united-states-adults
#1
Kelly Ryan Murphy, Jing L Han, Siyun Yang, Syed Mohammed Qasim Hussaini, Aladine A Elsamadicy, Beth Parente, Jichun Xie, Promila Pagadala, Shivanand P Lad
BACKGROUND: Patients with pain conditions place significant demands on health care services globally. Health economists have reported the annual economic cost of pain in the United States as high as $635 billion. A common challenge in treating patients suffering from chronic pain conditions is accurate diagnosis and treatment. OBJECTIVE: The aim of this study was to determine the modern-day prevalence of individual types of pain diagnoses in adults. STUDY DESIGN: Retrospective analysis of Truven MarketScan® Commercial and Medicare Supplemental database...
February 2017: Pain Physician
https://www.readbyqxmd.com/read/28154282/the-successful-treatment-of-a-cord-blood-transplant-recipient-with-varicella-zoster-virus-meningitis-radiculitis-and-myelitis-with-foscarnet
#2
Ryo Shimizu, Chikako Ohwada, Yuhei Nagao, Emi Togasaki, Chika Kawajiri, Tomoya Muto, Shokichi Tsukamoto, Shio Sakai, Yusuke Takeda, Naoya Mimura, Masahiro Takeuchi, Emiko Sakaida, Tohru Iseki, Chiaki Nakaseko
Infections of the central nervous system (CNS) with varicella zoster virus (VZV) is a rare occurrence after allogeneic hematopoietic stem cell transplantation. We herein report a case of VZV meningitis, radiculitis and myelitis that developed 8 months after cord blood transplantation, shortly after the cessation of cyclosporine and low-dose acyclovir. Although treatment with acyclovir did not achieve a satisfactory response, the patient was successfully treated with foscarnet. Our report indicates that VZV infection should be considered in allo-hematopoietic stem cell transplantation (HSCT) patients with CNS symptoms and that foscarnet may be effective for the treatment of acyclovir-resistant VZV infections of the CNS...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28109263/common-and-uncommon-neurological-manifestations-of-neuroborreliosis-leading-to-hospitalization
#3
Philipp Schwenkenbecher, Refik Pul, Ulrich Wurster, Josef Conzen, Kaweh Pars, Hans Hartmann, Kurt-Wolfram Sühs, Ludwig Sedlacek, Martin Stangel, Corinna Trebst, Thomas Skripuletz
BACKGROUND: Neuroborreliosis represents a relevant infectious disease and can cause a variety of neurological manifestations. Different stages and syndromes are described and atypical symptoms can result in diagnostic delay or misdiagnosis. The aim of this retrospective study was to define the pivotal neurological deficits in patients with neuroborreliosis that were the reason for admission in a hospital. METHODS: We retrospectively evaluated data of patients with neuroborreliosis...
January 21, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28009771/spontaneous-spinal-subdural-hematoma
#4
Marlijn H de Beer, Marjolein M Eysink Smeets, Hille Koppen
OBJECTIVE: Spinal subdural hematomas (SSDHs) are rare. Causes are (1) posttraumatic, (2) iatrogenic (following surgery or lumbar puncture), (3) spontaneous including underlying malformations or coagulation deficits. With a systematic review of literature we want to shed light on the last group: symptomatology, etiology, treatment and outcome will we discussed. METHODS: Systematic review of literature on PubMed for cases of acute nontraumatic noniatrogenic SSDHs in adults (≥18 y of age)...
January 2017: Neurologist
https://www.readbyqxmd.com/read/27992640/complications-associated-with-bone-morphogenetic-protein-in-the-lumbar-spine
#5
Daniel G Kang, Wellington K Hsu, Ronald A Lehman
Complications associated with the use of recombinant human bone morphogenetic protein in the lumbar spine include retrograde ejaculation, ectopic bone formation, vertebral osteolysis and subsidence, postoperative radiculitis, and hematoma and seroma. These complications are controversial and remain widely debated. This article discusses the reported complications and possible implications for the practicing spine surgeon. Understanding the complications associated with the use of recombinant human bone morphogenetic protein and the associated controversies allows for informed decision making by both the patient and the surgeon...
December 19, 2016: Orthopedics
https://www.readbyqxmd.com/read/27843683/spinal-neuromodulation-as-a-novel-surgical-option-for-failed-back-surgery-syndrome-following-rhbmp-exuberant-bony-growth-in-instrumented-lumbar-fusion-a-case-report-and-literature-review
#6
Ramsis F Ghaly, Alexei Lissounov, Tatiana Tverdohleb, David Kohanchi, Kenneth D Candido, Nebojsa Nick Knezevic
BACKGROUND: Bone morphogenic protein (BMP) for instrumented lumbar fusion was approved in 2002, and since then has led to an increasing incidence of BMP-related neuropathic pain. These patients are usually resistant to conventional medical therapy and frequently undergo multiple surgical revisions without any pain relief. CASE DESCRIPTION: A 58-year-old male was referred to the author's outpatient clinic after four lumbar surgeries did not provide satisfactory pain relief...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27818809/neurobrucellosis-a-case-report-from-himachal-pradesh-india-and-review-of-the-literature
#7
Sujeet Raina, Ashish Sharma, Rajesh Sharma, Amit Bhardwaj
Human brucellosis is a multisystem disease that commonly presents as a febrile illness along with variable spectrum of clinical manifestations. Neurological complications include encephalitis, meningoencephalitis, radiculitis, myelitis, peripheral and cranial neuropathies, subarachnoid hemorrhage, and psychiatric manifestations. We report a case diagnosed as neurobrucellosis who presented with fever and bilateral upper motor neuron symptoms and signs along with bilateral sensorineural deafness. Diagnosis was confirmed by Rose Bengal Test (RBT) and standard tube agglutination test (SAT)...
2016: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/27695170/wedgie-associated-radiculitis-in-a-quinquagenarian
#8
Courtney E Sutherland, Toban Dvoretzky, Nicholas J Solomos
Wedgies-the upward yanking of another's underpants from the rear to wedge them between the buttocks-can be administered playfully, maliciously, or adventurously; at forces ranging from gentle to "atomic"; and with or without the foreknowledge or consent of the recipient. Wedgies have been documented anecdotally in the popular Internet literature, with chief emphasis on their sensation-seeking or momentary entertainment value to the giver and recipient. Most participants are typically young; however, we report the case of a 50-year-old man who sustained chronic, painless radiculitis after he received an unanticipated wedgie of moderate force...
October 2016: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/27693929/diagnostic-values-of-proset-magnetic-resonance-coronal-source-imaging-for-detecting-symptomatic-lesion-in-multiple-lumbar-foraminal-stenosis
#9
So Hee Park, Ikchan Jeon, Sang Woo Kim
OBJECTIVE: The aim of this study is to evaluate the values of ProSet magnetic resonance coronal source imaging (ProSet MR imaging) as a diagnostic tool for detecting symptomatic lesion in patients with multiple lumbar foraminal stenosis. PATIENTS AND METHODS: From January 2011 to June 2015, 46 patients with unilateral and single-level radiculopathy developed from foraminal stenosis were enrolled in the study. These diagnoses were confirmed with transforaminal selective nerve root block (SNRB) and electrophysiological testing, including electromyography and nerve conduction velocity (EMG/NCV) tests...
November 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27645358/three-cases-of-herpes-zoster-radiculitis-in-ms-patients-treated-with-natalizumab
#10
Bassem I Yamout, Nuhad Abou Zeid, Ali J Taha, Maya M Zeineddine, Samia J Khoury
Natalizumab was the first FDA-approved monoclonal antibody for the treatment of multiple sclerosis (MS). We report on 3 natalizumab-treated patients who developed herpes zoster infections. In addition to progressive multifocal leukoencephelopathy, other opportunistic infections have been rarely reported during Natalizumab treatment. We believe that clinicians need heightened awareness of these infections in view of the risks of serious complications.
September 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27343729/rhbmp-2-induced-radiculitis-in-transforaminal-lumbar-interbody-patients-relationship-to-dose
#11
Alan T Villavicencio, Sigita Burneikiene
BACKGROUND CONTEXT: Recombinant human bone morphogenetic protein-2 (rhBMP-2) remains the primary synthetic osteoinductive material used in spinal fusion surgery today. The early inflammation reaction to rhBMP-2 manifesting with radicular symptoms has been previously reported in patients undergoing TLIF. There is a disagreement in regards to the factors affecting its occurrence and whether such symptoms are dose-dependent. PURPOSE: The purpose of this analysis was to determine the incidence of rhBMP-2 induced radiculitis and its relationship to dose...
June 22, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27243238/concurrent-radiotherapy-and-intrathecal-methotrexate-for-treating-leptomeningeal-metastasis-from-solid-tumors-with-adverse-prognostic-factors-a-prospective-and-single-arm-study
#12
Zhenyu Pan, Guozi Yang, Hua He, Gang Zhao, Tingting Yuan, Yu Li, Weiyan Shi, Pengxiang Gao, Lihua Dong, Yunqian Li
The prognosis of leptomeningeal metastasis (LM) from solid tumors is extremely poor, especially for patients with adverse prognostic factors. In this phase II clinical trial, we evaluated the efficacy and safety of intrathecal chemotherapy (IC) combined with concomitant involved-field radiotherapy (IF-RT) for treating LM from solid tumors with adverse prognostic factors. Fifty-nine patients with LM from various solid tumors were enrolled between May 2010 and December 2014. Concurrent therapy consisted of concomitant IC (methotrexate 12...
October 15, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27084345/neurological-respiratory-musculoskeletal-cardiac-and-ocular-side-effects-of-anti-pd-1-therapy
#13
Lisa Zimmer, Simone M Goldinger, Lars Hofmann, Carmen Loquai, Selma Ugurel, Ioannis Thomas, Maria I Schmidgen, Ralf Gutzmer, Jochen S Utikal, Daniela Göppner, Jessica C Hassel, Friedegund Meier, Julia K Tietze, Andrea Forschner, Carsten Weishaupt, Martin Leverkus, Renate Wahl, Ursula Dietrich, Claus Garbe, Michael C Kirchberger, Thomas Eigentler, Carola Berking, Anja Gesierich, Angela M Krackhardt, Dirk Schadendorf, Gerold Schuler, Reinhard Dummer, Lucie M Heinzerling
BACKGROUND: Anti-programmed cell death 1 (PD-1) antibodies represent an effective treatment option for metastatic melanoma and other cancer entities. They act via blockade of the PD-1 receptor, an inhibitor of the T-cell effector mechanisms that limit immune responses against tumours. As reported for ipilimumab, the anti-PD-1 antibodies pembrolizumab and nivolumab can induce immune-related adverse events (irAEs). These side-effects can involve skin, gastrointestinal tract, liver, the endocrine system and other organ systems...
June 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27014519/postoperative-cyst-associated-with-bone-morphogenetic-protein-use-in-posterior-and-transforaminal-lumbar-interbody-fusion-managed-conservatively-report-of-two-cases
#14
Eli M Baron, Diana M Mejía, Doniel Drazin, Neel Anand
Bone morphogenetic protein use in spinal surgery for off-label indications continues to remain popular. One area where its use has known associated radicular complications is posterior or transforaminal lumbar interbody fusion. These complications include radiculitis, cyst development, and heterotopic ossification, amongst others. Typically, cyst development has been treated surgically. We present two cases of bone morphogenetic protein-related cysts treated medically and thus, present medical treatment as an alternative treatment option...
2016: Curēus
https://www.readbyqxmd.com/read/26989976/evaluating-the-effects-of-recombinant-human-bone-morphogenetic-protein-2-on-pain-associated-behaviors-in-a-rat-model-following-implantation-near-the-sciatic-nerve
#15
John M Zanella, Nahid Waleh, Juan Orduña, Jose Montenegro, Jaime Paulin, William F McKay, Jared Wilsey
OBJECTIVE It has been hypothesized that the recombinant human bone morphogenetic protein-2 (rhBMP-2) amplification of the host inflammatory response interacts with nerves in the spine and contributes to the occurrence of new, postoperative complaints of radiculitis. This in vivo rat study was conducted to assess the capacity for rhBMP-2/ACS (rhBMP-2 applied to absorbable collagen sponge [ACS]) to stimulate pain-associated behaviors in the rat chronic constriction injury (CCI) model. METHODS Rats were randomly assigned to one of 14 treatment groups...
August 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/26904373/more-nerve-root-injuries-occur-with-minimally-invasive-lumbar-surgery-let-s-tell-someone
#16
Nancy E Epstein
BACKGROUND: In a recent study entitled: "More nerve root injuries occur with minimally invasive lumbar surgery, especially extreme lateral interbody fusion (XLIF): A review", Epstein documented that more nerve root injuries occurred utilizing minimally invasive surgery (MIS) versus open lumbar surgery for diskectomy, decompression of stenosis (laminectomy), and/or fusion for instability. METHODS: In large multicenter Spine Patient Outcomes Research Trial reviews performed by Desai et al...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/26904372/more-nerve-root-injuries-occur-with-minimally-invasive-lumbar-surgery-especially-extreme-lateral-interbody-fusion-a-review
#17
Nancy E Epstein
BACKGROUND: In the lumbar spine, do more nerve root injuries occur utilizing minimally invasive surgery (MIS) techniques versus open lumbar procedures? To answer this question, we compared the frequency of nerve root injuries for multiple open versus MIS operations including diskectomy, laminectomy with/without fusion addressing degenerative disc disease, stenosis, and/or degenerative spondylolisthesis. METHODS: Several of Desai et al. large Spine Patient Outcomes Research Trial studies showed the frequency for nerve root injury following an open diskectomy ranged from 0...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/26887329/absent-anti-n-methyl-d-aspartate-receptor-nr1a-antibodies-in-herpes-simplex-virus-encephalitis-and-varicella-zoster-virus-infections
#18
Benjamin Berger, Maximilian Pytlik, Tilman Hottenrott, Oliver Stich
PURPOSE: A 2012 report and subsequent case series described anti-N-methyl-D-aspartate receptor (NMDAR) antibodies in patients during the acute phase and relapse of herpes simplex virus 1 (HSV1) encephalitis (HSV1E). However, the prevalence of this phenomenon is unknown and systematic studies on other viral infections of the nervous system are missing. MATERIALS AND METHODS: We retrospectively analyzed serial cerebrospinal fluid (CSF) and serum samples of consecutive patients treated for neurological HSV1, HSV2 and varicella zoster virus (VZV) infections in our tertiary care university hospital between 2003 and 2013 for the presence of antibodies directed against the NR1a subunit of the NMDAR using indirect immunofluorescence...
February 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/26839995/medialized-muscle-splitting-approach-for-posterior-lumbar-interbody-fusion-technique-and-multicenter-perioperative-results
#19
Nitin Khanna, Gurvinder Deol, Gregory Poulter, Arvind Ahuja
STUDY DESIGN: Retrospective, multicenter study of perioperative results OBJECTIVE.: The purpose of this study was to describe the surgical technique for medialized posterior lumbar fusion as well as present preliminary complication and treatment results from a multicenter retrospective study. SUMMARY OF BACKGROUND DATA: Posterior exposures remain the most commonly performed approaches for spinal fusion. Conventional open posterior exposures, however, have relatively high exposure-related morbidity and postoperative infection rates...
April 2016: Spine
https://www.readbyqxmd.com/read/26766528/a-luetic-cauda-equina-meningoradiculitis-mimicking-a-central-nervous-system-lymphoma
#20
Jacopo Monticelli, Gabriele Bazzocchi, Roberto Luzzati
We report a case of peculiar neurosyphilis, initially misinterpreted as a lymphoproliferative disorder. This is also the first report to evaluate the utility of positron emission tomography-computed tomography in spinal cord syphilis. Cauda equina radiculitis is a rare manifestation of neurosyphilis whose diagnosis can be supported by the typical syphilitic exanthema.
February 2016: Sexually Transmitted Diseases
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