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Radiculitis

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https://www.readbyqxmd.com/read/27843683/spinal-neuromodulation-as-a-novel-surgical-option-for-failed-back-surgery-syndrome-following-rhbmp-exuberant-bony-growth-in-instrumented-lumbar-fusion-a-case-report-and-literature-review
#1
Ramsis F Ghaly, Alexei Lissounov, Tatiana Tverdohleb, David Kohanchi, Kenneth D Candido, Nebojsa Nick Knezevic
BACKGROUND: Bone morphogenic protein (BMP) for instrumented lumbar fusion was approved in 2002, and since then has led to an increasing incidence of BMP-related neuropathic pain. These patients are usually resistant to conventional medical therapy and frequently undergo multiple surgical revisions without any pain relief. CASE DESCRIPTION: A 58-year-old male was referred to the author's outpatient clinic after four lumbar surgeries did not provide satisfactory pain relief...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27818809/neurobrucellosis-a-case-report-from-himachal-pradesh-india-and-review-of-the-literature
#2
Sujeet Raina, Ashish Sharma, Rajesh Sharma, Amit Bhardwaj
Human brucellosis is a multisystem disease that commonly presents as a febrile illness along with variable spectrum of clinical manifestations. Neurological complications include encephalitis, meningoencephalitis, radiculitis, myelitis, peripheral and cranial neuropathies, subarachnoid hemorrhage, and psychiatric manifestations. We report a case diagnosed as neurobrucellosis who presented with fever and bilateral upper motor neuron symptoms and signs along with bilateral sensorineural deafness. Diagnosis was confirmed by Rose Bengal Test (RBT) and standard tube agglutination test (SAT)...
2016: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/27695170/wedgie-associated-radiculitis-in-a-quinquagenarian
#3
Courtney E Sutherland, Toban Dvoretzky, Nicholas J Solomos
Wedgies-the upward yanking of another's underpants from the rear to wedge them between the buttocks-can be administered playfully, maliciously, or adventurously; at forces ranging from gentle to "atomic"; and with or without the foreknowledge or consent of the recipient. Wedgies have been documented anecdotally in the popular Internet literature, with chief emphasis on their sensation-seeking or momentary entertainment value to the giver and recipient. Most participants are typically young; however, we report the case of a 50-year-old man who sustained chronic, painless radiculitis after he received an unanticipated wedgie of moderate force...
October 2016: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/27693929/diagnostic-values-of-proset-magnetic-resonance-coronal-source-imaging-for-detecting-symptomatic-lesion-in-multiple-lumbar-foraminal-stenosis
#4
So Hee Park, Ikchan Jeon, Sang Woo Kim
OBJECTIVE: The aim of this study is to evaluate the values of ProSet magnetic resonance coronal source imaging (ProSet MR imaging) as a diagnostic tool for detecting symptomatic lesion in patients with multiple lumbar foraminal stenosis. PATIENTS AND METHODS: From January 2011 to June 2015, 46 patients with unilateral and single-level radiculopathy developed from foraminal stenosis were enrolled in the study. These diagnoses were confirmed with transforaminal selective nerve root block (SNRB) and electrophysiological testing, including electromyography and nerve conduction velocity (EMG/NCV) tests...
November 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27645358/three-cases-of-herpes-zoster-radiculitis-in-ms-patients-treated-with-natalizumab
#5
Bassem I Yamout, Nuhad Abou Zeid, Ali J Taha, Maya M Zeineddine, Samia J Khoury
Natalizumab was the first FDA-approved monoclonal antibody for the treatment of multiple sclerosis (MS). We report on 3 natalizumab-treated patients who developed herpes zoster infections. In addition to progressive multifocal leukoencephelopathy, other opportunistic infections have been rarely reported during Natalizumab treatment. We believe that clinicians need heightened awareness of these infections in view of the risks of serious complications.
September 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27343729/rhbmp-2-induced-radiculitis-in-transforaminal-lumbar-interbody-patients-relationship-to-dose
#6
Alan T Villavicencio, Sigita Burneikiene
BACKGROUND CONTEXT: Recombinant human bone morphogenetic protein-2 (rhBMP-2) remains the primary synthetic osteoinductive material used in spinal fusion surgery today. The early inflammation reaction to rhBMP-2 manifesting with radicular symptoms has been previously reported in patients undergoing TLIF. There is a disagreement in regards to the factors affecting its occurrence and whether such symptoms are dose-dependent. PURPOSE: The purpose of this analysis was to determine the incidence of rhBMP-2 induced radiculitis and its relationship to dose...
June 22, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27243238/concurrent-radiotherapy-and-intrathecal-methotrexate-for-treating-leptomeningeal-metastasis-from-solid-tumors-with-adverse-prognostic-factors-a-prospective-and-single-arm-study
#7
Zhenyu Pan, Guozi Yang, Hua He, Gang Zhao, Tingting Yuan, Yu Li, Weiyan Shi, Pengxiang Gao, Lihua Dong, Yunqian Li
The prognosis of leptomeningeal metastasis (LM) from solid tumors is extremely poor, especially for patients with adverse prognostic factors. In this phase II clinical trial, we evaluated the efficacy and safety of intrathecal chemotherapy (IC) combined with concomitant involved-field radiotherapy (IF-RT) for treating LM from solid tumors with adverse prognostic factors. Fifty-nine patients with LM from various solid tumors were enrolled between May 2010 and December 2014. Concurrent therapy consisted of concomitant IC (methotrexate 12...
October 15, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27084345/neurological-respiratory-musculoskeletal-cardiac-and-ocular-side-effects-of-anti-pd-1-therapy
#8
Lisa Zimmer, Simone M Goldinger, Lars Hofmann, Carmen Loquai, Selma Ugurel, Ioannis Thomas, Maria I Schmidgen, Ralf Gutzmer, Jochen S Utikal, Daniela Göppner, Jessica C Hassel, Friedegund Meier, Julia K Tietze, Andrea Forschner, Carsten Weishaupt, Martin Leverkus, Renate Wahl, Ursula Dietrich, Claus Garbe, Michael C Kirchberger, Thomas Eigentler, Carola Berking, Anja Gesierich, Angela M Krackhardt, Dirk Schadendorf, Gerold Schuler, Reinhard Dummer, Lucie M Heinzerling
BACKGROUND: Anti-programmed cell death 1 (PD-1) antibodies represent an effective treatment option for metastatic melanoma and other cancer entities. They act via blockade of the PD-1 receptor, an inhibitor of the T-cell effector mechanisms that limit immune responses against tumours. As reported for ipilimumab, the anti-PD-1 antibodies pembrolizumab and nivolumab can induce immune-related adverse events (irAEs). These side-effects can involve skin, gastrointestinal tract, liver, the endocrine system and other organ systems...
June 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27014519/postoperative-cyst-associated-with-bone-morphogenetic-protein-use-in-posterior-and-transforaminal-lumbar-interbody-fusion-managed-conservatively-report-of-two-cases
#9
Eli M Baron, Diana M Mejía, Doniel Drazin, Neel Anand
Bone morphogenetic protein use in spinal surgery for off-label indications continues to remain popular. One area where its use has known associated radicular complications is posterior or transforaminal lumbar interbody fusion. These complications include radiculitis, cyst development, and heterotopic ossification, amongst others. Typically, cyst development has been treated surgically. We present two cases of bone morphogenetic protein-related cysts treated medically and thus, present medical treatment as an alternative treatment option...
2016: Curēus
https://www.readbyqxmd.com/read/26989976/evaluating-the-effects-of-recombinant-human-bone-morphogenetic-protein-2-on-pain-associated-behaviors-in-a-rat-model-following-implantation-near-the-sciatic-nerve
#10
John M Zanella, Nahid Waleh, Juan Orduña, Jose Montenegro, Jaime Paulin, William F McKay, Jared Wilsey
OBJECTIVE It has been hypothesized that the recombinant human bone morphogenetic protein-2 (rhBMP-2) amplification of the host inflammatory response interacts with nerves in the spine and contributes to the occurrence of new, postoperative complaints of radiculitis. This in vivo rat study was conducted to assess the capacity for rhBMP-2/ACS (rhBMP-2 applied to absorbable collagen sponge [ACS]) to stimulate pain-associated behaviors in the rat chronic constriction injury (CCI) model. METHODS Rats were randomly assigned to one of 14 treatment groups...
August 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/26904373/more-nerve-root-injuries-occur-with-minimally-invasive-lumbar-surgery-let-s-tell-someone
#11
Nancy E Epstein
BACKGROUND: In a recent study entitled: "More nerve root injuries occur with minimally invasive lumbar surgery, especially extreme lateral interbody fusion (XLIF): A review", Epstein documented that more nerve root injuries occurred utilizing minimally invasive surgery (MIS) versus open lumbar surgery for diskectomy, decompression of stenosis (laminectomy), and/or fusion for instability. METHODS: In large multicenter Spine Patient Outcomes Research Trial reviews performed by Desai et al...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/26904372/more-nerve-root-injuries-occur-with-minimally-invasive-lumbar-surgery-especially-extreme-lateral-interbody-fusion-a-review
#12
Nancy E Epstein
BACKGROUND: In the lumbar spine, do more nerve root injuries occur utilizing minimally invasive surgery (MIS) techniques versus open lumbar procedures? To answer this question, we compared the frequency of nerve root injuries for multiple open versus MIS operations including diskectomy, laminectomy with/without fusion addressing degenerative disc disease, stenosis, and/or degenerative spondylolisthesis. METHODS: Several of Desai et al. large Spine Patient Outcomes Research Trial studies showed the frequency for nerve root injury following an open diskectomy ranged from 0...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/26887329/absent-anti-n-methyl-d-aspartate-receptor-nr1a-antibodies-in-herpes-simplex-virus-encephalitis-and-varicella-zoster-virus-infections
#13
Benjamin Berger, Maximilian Pytlik, Tilman Hottenrott, Oliver Stich
PURPOSE: A 2012 report and subsequent case series described anti-N-methyl-D-aspartate receptor (NMDAR) antibodies in patients during the acute phase and relapse of herpes simplex virus 1 (HSV1) encephalitis (HSV1E). However, the prevalence of this phenomenon is unknown and systematic studies on other viral infections of the nervous system are missing. MATERIALS AND METHODS: We retrospectively analyzed serial cerebrospinal fluid (CSF) and serum samples of consecutive patients treated for neurological HSV1, HSV2 and varicella zoster virus (VZV) infections in our tertiary care university hospital between 2003 and 2013 for the presence of antibodies directed against the NR1a subunit of the NMDAR using indirect immunofluorescence...
February 17, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/26839995/medialized-muscle-splitting-approach-for-posterior-lumbar-interbody-fusion-technique-and-multicenter-perioperative-results
#14
Nitin Khanna, Gurvinder Deol, Gregory Poulter, Arvind Ahuja
STUDY DESIGN: Retrospective, multicenter study of perioperative results OBJECTIVE.: The purpose of this study was to describe the surgical technique for medialized posterior lumbar fusion as well as present preliminary complication and treatment results from a multicenter retrospective study. SUMMARY OF BACKGROUND DATA: Posterior exposures remain the most commonly performed approaches for spinal fusion. Conventional open posterior exposures, however, have relatively high exposure-related morbidity and postoperative infection rates...
April 2016: Spine
https://www.readbyqxmd.com/read/26766528/a-luetic-cauda-equina-meningoradiculitis-mimicking-a-central-nervous-system-lymphoma
#15
Jacopo Monticelli, Gabriele Bazzocchi, Roberto Luzzati
We report a case of peculiar neurosyphilis, initially misinterpreted as a lymphoproliferative disorder. This is also the first report to evaluate the utility of positron emission tomography-computed tomography in spinal cord syphilis. Cauda equina radiculitis is a rare manifestation of neurosyphilis whose diagnosis can be supported by the typical syphilitic exanthema.
February 2016: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/26700298/anti-inflammatory-effects-of-dexamethasone-and-meloxicam-on-borrelia-burgdorferi-induced-inflammation-in-neuronal-cultures-of-dorsal-root-ganglia-and-myelinating-cells-of-the-peripheral-nervous-system
#16
Geeta Ramesh, Olivia C Meisner, Mario T Philipp
BACKGROUND: Lyme neuroborreliosis (LNB), caused by the spirochete Borrelia burgdorferi (Bb), could result in cognitive impairment, motor dysfunction, and radiculoneuritis. We hypothesized that inflammation is a key factor in LNB pathogenesis and recently evaluated the effects of dexamethasone, a steroidal anti-inflammatory drug, and meloxicam a non-steroidal anti-inflammatory drug (NSAID), in a rhesus monkey model of acute LNB. Dexamethasone treatment significantly reduced the levels of immune mediators, and prevented inflammatory and/or neurodegenerative lesions in the central and peripheral nervous systems, and apoptosis in the dorsal root ganglia (DRG)...
December 23, 2015: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/26664404/dysuria-urinary-retention-and-inguinal-pain-as-manifestation-of-sacral-bannwarth-syndrome
#17
Josef Finsterer, Johannes Dauth, Kurt Angel, Mateusz Markowicz
Only few cases with sacral radiculitis due to infection with Borrelia burgdorferi leading to neurogenic urinary dysfunction have been reported. A 57-year-old male developed urethral pain and urinary retention, requiring permanent catheterization. Extensive urological investigations did not reveal a specific cause, which was why neurogenic bladder dysfunction was suspected. Neurologic exam revealed only mildly reduced tendon reflexes. Cerebral and spinal MRI were noninformative. CSF investigations, however, revealed pleocytosis, elevated protein, and antibodies against Borrelia burgdorferi...
2015: Case Reports in Medicine
https://www.readbyqxmd.com/read/26611556/corticosteroids-for-pain-of-spinal-origin-epidural-and-intraarticular-administration
#18
REVIEW
Louisa S Schilling, John D Markman
Targeted interventional delivery of corticosteroids remains a mainstay of treatment for spinal pain syndromes because this approach has a wider therapeutic index than other approaches. The best evidence for analgesic efficacy is in subacute radicular syndromes associated with new-onset or recurrent lumbar radiculitis. Complications often relate to drug delivery technique as much as actions of the steroid itself and require careful consideration and vigilance by the administering physician. Considerable uncertainty persists concerning which patients with chronic pain are most likely to benefit from corticosteroid injections...
February 2016: Rheumatic Diseases Clinics of North America
https://www.readbyqxmd.com/read/26606031/efficacy-of-epidural-injections-in-managing-chronic-spinal-pain-a-best-evidence-synthesis
#19
REVIEW
Alan D Kaye, Laxmaiah Manchikanti, Salahadin Abdi, Sairam Atluri, Sanjay Bakshi, Ramsin Benyamin, Mark V Boswell, Ricardo Buenaventura, Kenneth D Candido, Harold J Cordner, Sukdeb Datta, Gulshan Doulatram, Christopher G Gharibo, Vahid Grami, Sanjeeva Gupta, Sachin Jha, Eugene D Kaplan, Yogesh Malla, Dharam P Mann, Devi E Nampiaparampil, Gabor Racz, Prithvi Raj, Maunak V Rana, Manohar Lal Sharma, Vijay Singh, Amol Soin, Peter S Staats, Ricardo Vallejo, Bradley W Wargo, Joshua A Hirsch
BACKGROUND: Epidural injections have been used since 1901 in managing low back pain and sciatica. Spinal pain, disability, health, and economic impact continue to increase, despite numerous modalities of interventions available in managing chronic spinal pain. Thus far, systematic reviews performed to assess the efficacy of epidural injections in managing chronic spinal pain have yielded conflicting results. OBJECTIVE: To evaluate and update the clinical utility of the efficacy of epidural injections in managing chronic spinal pain...
November 2015: Pain Physician
https://www.readbyqxmd.com/read/26601457/lyme-disease
#20
REVIEW
B Chomel
Lyme disease is among the most frequently diagnosed zoonotic tick-borne diseases worldwide. The number of human cases has been on the increase since the first recognition of its aetiological agent. Lyme disease is caused by spirochete bacteria belonging to the genus Borrelia, with B. burgdorferi sensu stricto (s.s.) found in the Americas, and B. afzelii and B. garinii, in addition to B. burgdorferi s.s., in Europe and Asia. Environmental factors, such as human encroachment onto habitats favourable to ticks and their hosts, reduced deforestation, increased human outdoor activities, and climatic factors favouring a wider distribution of tick vectors, have enhanced the impact of the disease on both humans and animals...
August 2015: Revue Scientifique et Technique
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