keyword
MENU ▼
Read by QxMD icon Read
search

tissue engineered vascular graft

keyword
https://www.readbyqxmd.com/read/28941163/colorectal-wall-regeneration-resulting-from-the-association-of-chitosan-hydrogel-and-stromal-vascular-fraction-from-adipose-tissue
#1
Quentin Denost, Arnaud Pontallier, Etienne Buscail, Alexandra Montembault, Reine Bareille, Robin Siadous, Marlene Durand, Samantha Delmond, Laurent David, Laurence Bordenave
Chitosan hydrogel and Adipose Derived Stem Cells (ADCS) have been reported as the optimal partnership for colorectal tissue engineering. In that field, the aim of the current experiment was to asses, the interest of seeding ADSC on chitosan hydrogel patches in an in vivo comparative study and on a tube intended replace a colonic segment in an in vivo feasibility study. In the comparative study, a 2x3 cm colonic wall defect was performed in 20 swines and repaired by suturing a chitosan hydrogel patch: acellular matrix (Group A, n=10) vs...
September 22, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28932749/vascular-tissue-engineering-effects-of-integrating-collagen-into-a-pcl-based-nanofiber-material
#2
Ulf Bertram, Dominik Steiner, Benjamin Poppitz, Dirk Dippold, Katrin Köhn, Justus P Beier, Rainer Detsch, Aldo R Boccaccini, Dirk W Schubert, Raymund E Horch, Andreas Arkudas
The engineering of vascular grafts is a growing field in regenerative medicine. Although numerous attempts have been made, the current vascular grafts made of polyurethane (PU), Dacron®, or Teflon® still display unsatisfying results. Electrospinning of biopolymers and native proteins has been in the focus of research to imitate the extracellular matrix (ECM) of vessels to produce a small caliber, off-the-shelf tissue engineered vascular graft (TEVG) as a substitute for poorly performing PU, Dacron, or Teflon prostheses...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28914404/development-and-characterization-of-hybrid-tubular-structure-of-plcl-porous-scaffold-with-hmscs-ecs-cell-sheet
#3
Azizah Intan Pangesty, Takaaki Arahira, Mitsugu Todo
Tissue engineering offers an alternate approach to providing vascular graft with potential to grow similar with native tissue by seeding autologous cells into biodegradable scaffold. In this study, we developed a combining technique by layering a sheet of cells onto a porous tubular scaffold. The cell sheet prepared from co-culturing human mesenchymal stem cells (hMSCs) and endothelial cells (ECs) were able to infiltrate through porous structure of the tubular poly (lactide-co-caprolactone) (PLCL) scaffold and further proliferated on luminal wall within a week of culture...
September 15, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28914400/an-in-vivo-study-on-endothelialized-vascular-grafts-produced-by-autologous-biotubes-and-adipose-stem-cells-adscs
#4
Yu Chieh Tseng, Jun Neng Roan, Ying Chiang Ho, Chih Chan Lin, Ming Long Yeh
Currently, commercial synthetic vascular grafts made from Dacron and ePTFE for small-diameter, vascular applications (<6 mm) show limited reendothelization and are less compliant, often resulting in thrombosis and intimal hyperplasia. Although good blood compatibility can be achieved in autologous arteries and veins, the number of high quality harvest sites is limited, and the grafts are size-mismatched for use in the fistula or cardiovascular bypass surgery; thus, alternative small graft substitutes must be developed...
September 15, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28906326/tissue-engineering-strategies-for-auricular-reconstruction
#5
Michael J Schroeder, Mark S Lloyd
Simulating natural characteristics and aesthetics in reconstructed ears has provided a complex 3-dimensional puzzle for those treating patients with microtia. Costochondral grafts remain the gold standard for autologous reconstruction. However, other options such as Medpor and prosthetics are indicated depending on patient circumstances and personal choice. Research into tissue engineering offers an alternative method to a traditional surgical approach that may reduce donor-site morbidity. However, tissue engineering for microtia reconstruction brings new challenges such as cell sourcing, promotion of chondrogenesis, scaffold vascularization, and prevention of scaffold contraction...
September 12, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28893630/engineered-axially-vascularized-osteogenic-grafts-from-human-adipose-derived-cells-to-treat-avascular-necrosis-of-bone-in-a-rat-model
#6
Tarek Ismail, Rik Osinga, Atanas Todorov, Alexander Haumer, Laurent A Tchang, Christian Epple, Nima Allafi, Nadia Menzi, René D Largo, Alexandre Kaempfen, Ivan Martin, Dirk J Schaefer, Arnaud Scherberich
BACKGROUND: Avascular necrosis of bone (AVN) leads to sclerosis and collapse of bone and joints. The standard of care, vascularized bone grafts, is limited by donor site morbidity and restricted availability. The aim of this study was to generate and test engineered, axially vascularized SVF cells-based bone substitutes in a rat model of AVN. METHODS: SVF cells were isolated from lipoaspirates and cultured onto porous hydroxyapatite scaffolds within a perfusion-based bioreactor system for 5 days...
September 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28887992/electrospun-vein-grafts-with-high-cell-infiltration-for-vascular-tissue-engineering
#7
Zhikai Tan, Xiangkai Gao, Tong Liu, Yikun Yang, Juchang Zhong, Chunyi Tong, Yongjun Tan
Demand is increasing for functional small-diameter vascular grafts (diameter<6mm) for clinical arterial replacement. In the present study, we develop a bilayer poly(ε-caprolactone, PCL) fibrous vascular graft consisting of a thin internal layer made of longitudinally aligned fibers and a relatively thick highly porous external layer. The internal layer provides a scaffold with the necessary mechanical strength and enhances the growth of endothelial cells, whereas the external layer enhances cell motility through the scaffold bulk...
December 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28887711/in-vitro-remodeling-and-structural-characterization-of-degradable-polymer-scaffold-based-tissue-engineered-vascular-grafts-using-optical-coherence-tomography
#8
Wanwen Chen, Junqing Yang, Wenjun Liao, Jiahui Zhou, Jianyi Zheng, Yueheng Wu, Dongfeng Li, Zhanyi Lin
Non-destructive imaging strategies to monitor long-term cultures is essential for vascular engineering. The goal of this study is to investigate whether optical coherence tomography (OCT) can be a suitable approach to monitor the long-term remodeling process of biodegradable polymeric scaffold-based tissue-engineered vascular grafts (TEVG) after pulsatile stimulation and to observe polymeric scaffold degradation during bioreactor cultivation. In the present study, a perfusion system driven by a ventricular assist device was provided for a three-dimensional culture system as a pulsatile force...
September 8, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28886204/stress-analysis-driven-design-of-bilayered-scaffolds-for-tissue-engineered-vascular-grafts
#9
Jason M Szafron, Christopher Breuer, Yadong Wang, Jay Humphrey
Continuing advances in the fabrication of scaffolds for tissue engineered vascular grafts is greatly expanding the scope of potential designs. Increasing recognition of the importance of local biomechanical cues for cell-mediated neotissue formation, neovessel growth, and subsequent remodeling is similarly influencing the design process. This study examines directly the potential effects of different combinations of key geometric and material properties of polymeric scaffolds on the initial mechanical state of an implanted graft into which cells are seeded or migrate...
September 8, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28885576/porcine-bone-scaffolds-adsorb-growth-factors-secreted-by-mscs-and-improve-bone-tissue-repair
#10
Eitan Mijiritsky, Letizia Ferroni, Chiara Gardin, Eriberto Bressan, Gastone Zanette, Adriano Piattelli, Barbara Zavan
An ideal tissue-engineered bone graft should have both excellent pro-osteogenesis and pro-angiogenesis properties to rapidly realize the bone regeneration in vivo. To meet this goal, in this work a porcine bone scaffold was successfully used as a Trojan horse to store growth factors produced by mesenchymal stem cells (MSCs). This new scaffold showed a time-dependent release of bioactive growth factors, such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), in vitro. The biological effect of the growth factors-adsorbed scaffold on the in vitro commitment of MSCs into osteogenic and endothelial cell phenotypes has been evaluated...
September 8, 2017: Materials
https://www.readbyqxmd.com/read/28879686/development-of-a-bioactive-porous-collagen-%C3%AE-tricalcium-phosphate-bone-graft-assisting-rapid-vascularization-for-bone-tissue-engineering-applications
#11
Nafiseh Baheiraei, Mohamma Reza Nourani, Sm Javad Mortazavi, Mansoureh Movahedin, Hossein Eyni, Fatemeh Baghery, Mohammad Hadi Norahan
We developed collagen (COL) and collagen/beta tricalcium phosphate (COL/β-TCP) scaffolds with a β-TCP/collagen weight ratio of 4 by freeze-drying. Mouse bone marrow-derived mesenchymal stem cells (BMMSCs) were cultured on these scaffolds for 14 days. Samples were characterized by physicochemical analyses and their biological properties such as cell viability and alkaline phosphatase (ALP) activity was,also, examined. Additionally, the vascularization potential of the prepared scaffolds was tested subcutaneously in Wistar rats...
September 6, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28875528/transplantation-of-artificial-human-lymphatic-vascular-tissues-fabricated-using-a-cell-accumulation-technique-and-their-engraftment-in-mouse-tissue-with-vascular-remodeling
#12
Yoshiya Asano, Hiroshi Shimoda, Michiya Matsusaki, Mitsuru Akashi
Transplantation of engineered tissues with microvascular structure is advancing towards therapeutic application to improve the flow of blood and/or lymphatic fluids. In lymphatic disorders, transplantation of tissue-engineered lymphatic grafts can be an ideal treatment for draining excessive lymphatic fluid. In this study, we examined the transplantation of three-dimensional artificial human lymphatic network tissue (AHLT) fabricated by the cell accumulation technique into the subcutaneous tissue and fascia of mice...
September 6, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28868207/host-non-inflammatory-neutrophils-mediate-the-engraftment-of-bioengineered-vascular-networks
#13
Ruei-Zeng Lin, Chin Nien Lee, Rafael Moreno-Luna, Joseph Neumeyer, Breanna Piekarski, Pingzhu Zhou, Marsha A Moses, Monisha Sachdev, William T Pu, Sitaram Emani, Juan M Melero-Martin
Notwithstanding remarkable progress in vascular network engineering, implanted bioengineered microvessels largely fail to form anastomoses with the host vasculature. Here, we demonstrate that implants containing assembled human vascular networks (A-Grafts) fail to engraft due to their inability to engage non-inflammatory host neutrophils upon implantation into mice. In contrast, unassembled vascular cells (U-Grafts) readily engage alternatively polarized neutrophils, which in turn serve as indispensable mediators of vascular assembly and anastomosis...
2017: Nature biomedical engineering
https://www.readbyqxmd.com/read/28864251/living-nanofiber-yarn-based-woven-biotextiles-for-tendon-tissue-engineering-using-cell-tri-culture-and-mechanical-stimulation
#14
Shaohua Wu, Ying Wang, Philipp N Streubel, Bin Duan
Non-woven nanofibrous scaffolds have been developed for tendon graft application by using electrospinning strategies. However, electrospun nanofibrous scaffolds face some obstacles and limitations, including suboptimal scaffold structure, weak tensile and suture-retention strengths, and compact structure for cell infiltration. In this work, a novel nanofibrous, woven biotextile, fabricated based on electrospun nanofiber yarns, was implemented as a tissue engineered tendon scaffold. Based on our modified electrospinning setup, polycaprolactone (PCL) nanofiber yarns were fabricated with reproducible quality, and were further processed into plain-weaving fabrics interlaced with polylactic acid (PLA) multifilaments...
August 30, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28862056/the-use-of-engineered-bilayered-skin-myderm-tm-in-the-management-of-massive-skin-defect-in-grade-iii-gustilo-anderson-open-fracture
#15
Nor Hazla Mohamed Haflah, Min Hwei Ng, Mohd Heikal Mohd Yunus, Amaramalar Selvee Naicker, Ohnmar Htwe, Muhammad Fahmi, Mohamad Fikeri Ishak, Wan Tai Seet, Khairul Anuar Khairoji, Manira Maarof, Kien Hui Chua, Sharen Aini Shamsuddin, Ruszymah Idrus
Open fracture Gustilo-Anderson grade IIIC is associated with higher risk of infection and problems with soft tissue coverage. Various methods have been used for soft tissue coverage in open fractures with large skin defect. We report a case of a patient who had grade IIIC open fracture of the tibia with posterior tibial artery injury. The patient underwent external fixation and reduction. Because of potential compartment syndrome after vascular repair, fasciotomy of the posterior compartment was performed. This wound, however, became infected and because of further debridement, gave rise to a large skin defect...
September 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/28817384/engineering-the-mechanical-and-biological-properties-of-nanofibrous-vascular-grafts-for-in-situ-vascular-tissue-engineering
#16
Jeffrey J D Henry, Jian Yu, Aijun Wang, Randall Lee, Jun Fang, Song Li
Synthetic small diameter vascular grafts have a high failure rate, and endothelialization is critical for preventing thrombosis and graft occlusion. A promising approach is in situ tissue engineering, whereby an acellular scaffold is implanted and provides stimulatory cues to guide the in situ remodeling into a functional blood vessel. An ideal scaffold should have sufficient binding sites for biomolecule immobilization and a mechanical property similar to native tissue. Here we developed a novel method to blend low molecular weight (LMW) elastic polymer during electrospinning process to increase conjugation sites and to improve the mechanical property of vascular grafts...
August 17, 2017: Biofabrication
https://www.readbyqxmd.com/read/28816087/small-diameter-vascular-graft-with-fibroblast-cells-and-electrospun-poly-l-lactide-co-%C3%AE%C2%B5-caprolactone-scaffolds-cell-matrix-engineering
#17
Bong Seok Jang, Ja Young Cheon, Soo Hyun Kim, Won Ho Park
Electrospun scaffolds have been widely used in tissue engineering due to their similar structure to native extracellular matrices (ECM). However, one of the obstacles limiting the application of electrospun scaffolds for tissue engineering is the nano-sized pores, which inhibit cell infiltration into the scaffolds. To overcome this limitation, we approached to make layers which are consisted of cells onto the electrospun sheet and then tubular structure was constructed by rolling. We called this as 'Cell Matrix Engineering' because the electrospun sheets were combined with the cells to form one matrix...
August 23, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28805140/a-rat-model-for-the-in-vivo-assessment-of-biological-and-tissue-engineered-valvular-and-vascular-grafts
#18
Yukiharu Sugimura, Anna Kathrin Schmidt, Artur Lichtenberg, Alexander Assmann, Payam Akhyari
The demand for an improvement of the biocompatibility and durability of vascular and valvular implants requires translational animal models to study the in vivo fate of cardiovascular grafts. In the present article, a review on the development and application of a microsurgical rat model of infrarenal implantation of aortic grafts and aortic valved conduits is provided. By refinement of surgical techniques and inclusion of hemodynamic considerations, a functional model has been created, which provides a modular platform for the in vivo assessment of biological and tissue-engineered grafts...
September 20, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28762052/in-vitro-mechanical-property-evaluation-of-chitosan-based-hydrogels-intended-for-vascular-graft-development
#19
Audrey Aussel, Alexandra Montembault, Sébastien Malaise, Marie Pierre Foulc, William Faure, Sandro Cornet, Rachida Aid, Marc Chaouat, Thierry Delair, Didier Letourneur, Laurent David, Laurence Bordenave
Vascular grafts made of synthetic polymers perform poorly in cardiac and peripheral bypass applications. In these applications, chitosan-based materials can be produced and shaped to provide a novel scaffold for vascular tissue engineering. The goal of this study was to evaluate in vitro the mechanical properties of a novel chitosan formulation to assess its potential for this scaffold. Two chitosan-based hydrogel tubes were produced by modulating chitosan concentration. Based on the standard ISO 7198:1998, the hydrogel tubes were characterized in vitro in terms of suture retention strength, tensile strength, compliance, and burst pressure...
July 31, 2017: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/28754230/tissue-engineered-vascular-grafts-for-congenital-cardiac-disease-clinical-experience-and-current-status
#20
REVIEW
Joseph D Drews, Hideki Miyachi, Toshiharu Shinoka
Congenital heart disease is a leading cause of death in the newborn period, and man-made grafts currently used for reconstruction are associated with multiple complications. Tissue engineering can provide an alternative source of vascular tissue in congenital cardiac surgery. Clinical trials have been successful overall, but the most frequent complication is graft stenosis. Recent studies in animal models have indicated the important role of the recipient׳s immune response in neotissue formation, and that modulating the immune response can reduce the incidence of stenosis...
June 21, 2017: Trends in Cardiovascular Medicine
keyword
keyword
68193
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"