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tissue engineered vascular graft

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https://www.readbyqxmd.com/read/28524773/the-role-of-myeloid-cell-derived-pdgf-b-in-neotissue-formation-in-a-tissue-engineered-vascular-graft
#1
Ekene Onwuka, Cameron Best, Andrew Sawyer, Tai Yi, Eric Heuer, Malik Sams, Matthew Wiet, Hong Zheng, Themis Kyriakides, Christopher Breuer
AIM: Inflammatory myeloid lineage cells mediate neotissue formation in tissue-engineered vascular grafts, but the molecular mechanism is not completely understood. We examined the role of vasculogenic PDGF-B in tissue-engineered vascular graft neotissue development. MATERIALS & METHODS: Myeloid cell-specific PDGF-B knockout mice (PDGF-KO) were generated using bone marrow transplantation, and scaffolds were implanted as inferior vena cava interposition grafts in either PDGF-KO or wild-type mice...
May 19, 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28494781/preparation-and-characterization-of-small-diameter-decellularized-scaffolds-for-vascular-tissue-engineering-in-an-animal-model
#2
Shuangyue Xu, Fangna Lu, Lianna Cheng, Chenglin Li, Xu Zhou, Yuan Wu, Hongxing Chen, Kaichuang Zhang, Lumin Wang, Junjie Xia, Guoliang Yan, Zhongquan Qi
BACKGROUND: The development of a suitable extracellular matrix (ECM) scaffold is the first step in vascular tissue engineering (VTE). Synthetic vascular grafts are available as an alternative to autologous vessels in large-diameter arteries (>8 mm) and medium-diameter arteries (6-8 mm). In small-diameter vessels (<6 mm), synthetic vascular grafts are of limited use due to poor patency rates. Compared with a vascular prosthesis, natural tissue ECM has valuable advantages. Despite considerable progress in recent years, identifying an optimal protocol to create a scaffold for use in small-diameter (<6 mm) fully natural tissue-engineered vascular grafts (TEVG), remains elusive...
May 11, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28486019/role-of-bone-marrow-mononuclear-cell-seeding-for-nanofiber-vascular-grafts
#3
Takuma Fukunishi, Cameron A Best, Chin Siang Ong, Tyler Groehl, James Reinhardt, Tai Yi, Hideki Miyachi, Huaitao Zhang, Toshiharu Shinoka, Christopher K Breuer, Jed Johnson, Narutoshi Hibino
OBJECTIVE: Electrospinning is a promising technology that provides biodegradable nanofiber scaffolds for cardiovascular tissue engineering. However, success with these materials has been limited, and the optimal combination of scaffold parameters for a tissue-engineered vascular graft (TEVG) remains elusive. The purpose of the present study is to evaluate the effect of bone marrow mononuclear cell (BM-MNC) seeding in electrospun scaffolds to support the rational design of optimized TEVGs...
May 9, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28485303/synthesis-of-cell-composite-alginate-microfibers-by-microfluidics-with-the-application-potential-of-small-diameter-vascular-grafts
#4
Mingying Liu, Zhizhi Zhou, Yongchao Chai, Shuai Zhang, Xiaomeng Wu, Shaopeng Huang, Jiaqiang Su, Jiahuan Jiang
Fabrication of small diameter vascular grafts (SDVGs) with appropriate responses for clinical application remains is still challenging. In the present work, the production and characterization of solid alginate based microfibers as potential SDVG candidates through the methods of microfluidics were considered original. A simple glass microfluidic device with a "L-shape" cylindrical-flow channel in the microfluidic platform was developed. The gelation of microfibers occurred when the alginate solution and a CaCl2 solution were introduced as a core flow and as a sheath flow respectively...
May 9, 2017: Biofabrication
https://www.readbyqxmd.com/read/28467648/building-better-bone-the-weaving-of-biologic-and-engineering-strategies-for-managing-bone-loss
#5
Andrew M Schwartz, Mara L Schenker, Jaimo Ahn, Nick J Willett
Segmental bone loss remains a challenging clinical problem for orthopaedic trauma surgeons. In addition to the missing bone itself, the local tissues (soft tissue, vascular) are often highly traumatized as well, resulting in a less than ideal environment for bone regeneration. As a result, attempts at limb salvage become a highly expensive endeavor, often requiring multiple operations and necessitating the use of every available strategy (autograft, allograft, bone graft substitution, Masquelet, bone transport, etc...
May 3, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28457188/functional-tissue-engineering-a-prevascularized-cardiac-muscle-construct-for-validating-hmscs-engraftment-potential-in-vitro
#6
Mani Thiruvanamalai Valarmathi, John W Fuseler, Jay D Potts, Jeffrey M Davis, Robert L Price
The influence of somatic stem cells in the stimulation of mammalian cardiac muscle regeneration is still in its early stages, and so far, it has been difficult to determine the efficacy of the procedures that have been employed. The outstanding question remains whether stem cells derived from the bone marrow or some other location within or outside of the heart can populate a region of myocardial damage and transform into tissue-specific differentiated progenies, and also exhibit functional synchronization...
April 29, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28447994/scaling-of-engineered-vascular-grafts-using-3d-printed-guides-and-the-ring-stacking-method
#7
Cameron B Pinnock, Zhengfan Xu, Mai T Lam
Coronary artery disease remains a leading cause of death, affecting millions of Americans. With the lack of autologous vascular grafts available, engineered grafts offer great potential for patient treatment. However, engineered vascular grafts are generally not easily scalable, requiring manufacture of custom molds or polymer tubes in order to customize to different sizes, constituting a time-consuming and costly practice. Human arteries range in lumen diameter from about 2.0-38 mm and in wall thickness from about 0...
March 27, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28447487/tissue-engineered-vascular-grafts-current-state-of-the-field
#8
Chin Siang Ong, Xun Zhou, Chen Yu Huang, Takuma Fukunishi, Huaitao Zhang, Narutoshi Hibino
Conventional synthetic vascular grafts are limited by the inability to remodel, as well as issues of patency at smaller diameters. Tissue-engineered vascular grafts (TEVGs), constructed from biologically active cells and biodegradable scaffolds have the potential to overcome these limitations, and provide growth capacity and self-repair. Areas covered: This article outlines the TEVG design, biodegradable scaffolds, TEVG fabrication methods, cell seeding, drug delivery, strategies to reduce wait times, clinical trials, as well as a 5-year view with expert commentary...
May 9, 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28415397/surface-modified-bioresorbable-electrospun-scaffolds-for-improving-hemocompatibility-of-vascular-grafts
#9
Pablo C Caracciolo, María Isabel Rial-Hermida, Florencia Montini-Ballarin, Gustavo A Abraham, Angel Concheiro, Carmen Alvarez-Lorenzo
The replacement of small-diameter vessels is one of the main challenges in tissue engineering. Moreover, the surface modification of small-diameter vascular grafts (SDVG) is a key factor in the success of the therapy due to their increased thrombogenicity and infection susceptibility caused by the lack of a functional endothelium. In this work, electrospun scaffolds were prepared from blends of poly(L-lactic acid) (PLLA) and segmented polyurethane (PHD) with a composition designed to perform as SDVG inner layer...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28413258/fluorinated-polyurethane-scaffolds-for-19-f-magnetic-resonance-imaging
#10
Twan Lammers, Marianne E Mertens, Philipp Schuster, Khosrow Rahimi, Yang Shi, Volkmar Schulz, Alexander J C Kuehne, Stefan Jockenhoevel, Fabian Kiessling
Polymers are increasingly employed in implant materials. To reduce the incidence of complications, which in the case of vascular grafts include incorrect placement and restenosis, materials are needed which allow for image-guided implantation, as well as for accurate and efficient postoperative implant imaging. We here describe amorphous fluorinated polymers based on thermoplastic polyurethane ((19)F-TPU), and show that are useful starting materials for developing tissue-engineered vascular grafts which can be detected using (19)F MRI...
April 11, 2017: Chemistry of Materials: a Publication of the American Chemical Society
https://www.readbyqxmd.com/read/28386538/biofabrication-and-bone-tissue-regeneration-cell-source-approaches-and-challenges
#11
REVIEW
Monia Orciani, Milena Fini, Roberto Di Primio, Monica Mattioli-Belmonte
The growing occurrence of bone disorders and the increase in aging population have resulted in the need for more effective therapies to meet this request. Bone tissue engineering strategies, by combining biomaterials, cells, and signaling factors, are seen as alternatives to conventional bone grafts for repairing or rebuilding bone defects. Indeed, skeletal tissue engineering has not yet achieved full translation into clinical practice because of several challenges. Bone biofabrication by additive manufacturing techniques may represent a possible solution, with its intrinsic capability for accuracy, reproducibility, and customization of scaffolds as well as cell and signaling molecule delivery...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28382923/a-compliant-and-biomimetic-three-layered-vascular-graft-for-small-blood-vessels
#12
Yi Zhang, Xiangshun Li, Géraldine Guex, Shanshan Liu, Eike Müller, Riccardo Innocenti Malini, Huijing Zhao, Markus Rottmar, Katharina Maniura, Rene Rossi, Fabrizio Spano
Engineering a small diameter vascular graft with mechanical and biological properties comparable to living tissues remains challenging. Often, current devices lead to thrombosis and unsatisfactory long-term patency as a result of poor blood compatibility and a mismatch between the mechanical properties of the living tissue and the implanted biomaterial. Address-ing all these requirements is essential to produce scaffolds able to survive throughout the life of the patient. For this purpose, we fabricated a novel three-layered vascular graft by combining electrospinning and braiding...
April 6, 2017: Biofabrication
https://www.readbyqxmd.com/read/28382732/engineering-vascularized-flaps-using-adipose-derived-microvascular-ec-and-msc
#13
Alina Freiman, Yulia Shandalov, Dekel Rosenfeld, Erez Shor, Dror Ben-David, Shai Meretzki, Shulamit Levenberg, Dana Egozi
Human adipose-derived microvascular endothelial cells (HAMEC) and mesenchymal stem cells (MSC) have been shown to bear angiogenic and vasculogenic capabilities. We hypothesize that co-culturing HAMEC:MSC on a porous biodegradable scaffold in vitro, later implanted as a graft around femoral blood vessels in a rat, will result in its vascularization by host vessels, creating a functional vascular flap that can effectively treat a range of large full-thickness soft tissue defects. HAMEC were co-cultured with MSC on polymeric 3D porous constructs...
April 6, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28371505/compositions-including-synthetic-and-natural-blends-for-integration-and-structural-integrity-engineered-for-different-vascular-graft-applications
#14
REVIEW
Mozhgan Shojaee, Chris A Bashur
Tissue engineering approaches for small-diameter arteries require a scaffold that simultaneously maintains patency by preventing thrombosis and intimal hyperplasia, maintains its structural integrity after grafting, and allows integration. While synthetic and extracellular matrix-derived materials can provide some of these properties individually, developing a scaffold that provides the balanced properties needed for vascular graft survival in the clinic has been particularly challenging. After 30 years of research, there are now several scaffolds currently in clinical trials...
March 29, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28367979/extracellular-vesicle-functionalized-decalcified-bone-matrix-scaffolds-with-enhanced-pro-angiogenic-and-pro-bone-regeneration-activities
#15
Hui Xie, Zhenxing Wang, Liming Zhang, Qian Lei, Aiqi Zhao, Hongxiang Wang, Qiubai Li, Yilin Cao, Wen Jie Zhang, Zhichao Chen
Vascularization is crucial for bone regeneration after the transplantation of tissue-engineered bone grafts in the clinical setting. Growing evidence suggests that mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) are potently pro-angiogenic both in vitro and in vivo. In the current study, we fabricated a novel EV-functionalized scaffold with enhanced pro-angiogenic and pro-bone regeneration activities by coating decalcified bone matrix (DBM) with MSC-derived EVs. EVs were harvested from rat bone marrow-derived MSCs and the pro-angiogenic potential of EVs was investigated in vitro...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28348177/historical-perspective-and-future-direction-of-blood-vessel-developments
#16
Sashka Dimitrievska, Laura E Niklason
Over the past 40 years, remarkable advances have been made in our understanding of successful blood vessel regeneration, starting with the failures of early tissue-engineered vascular grafts designed using isolated components or molecules, such as collagen gels. The vascular tissue engineers are today better educated and have steered ongoing research developments toward clinical developments of more complete vascular grafts that replicate the multitude of specialized arterial aspects required for function.
March 27, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/28341826/poly-ethylmethacrylate-co-diethylaminoethyl-acrylate-coating-improves-endothelial-re-population-bio-mechanical-and-anti-thrombogenic-properties-of-decellularized-carotid-arteries-for-blood-vessel-replacement
#17
Elena López-Ruiz, Seshasailam Venkateswaran, Macarena Perán, Gema Jiménez, Salvatore Pernagallo, Juan J Díaz-Mochón, Olga Tura-Ceide, Francisco Arrebola, Juan Melchor, Juan Soto, Guillermo Rus, Pedro J Real, María Diaz-Ricart, Antonio Conde-González, Mark Bradley, Juan A Marchal
Decellularized vascular scaffolds are promising materials for vessel replacements. However, despite the natural origin of decellularized vessels, issues such as biomechanical incompatibility, immunogenicity risks and the hazards of thrombus formation, still need to be addressed. In this study, we coated decellularized vessels obtained from porcine carotid arteries with poly (ethylmethacrylate-co-diethylaminoethylacrylate) (8g7) with the purpose of improving endothelial coverage and minimizing platelet attachment while enhancing the mechanical properties of the decellularized vascular scaffolds...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28332447/the-effect-of-native-silk-fibroin-powder-on-the-physical-properties-and-biocompatibility-of-biomedical-polyurethane-membrane
#18
Yan Zhuang, Qian Zhang, Jinqi Feng, Na Wang, Weilin Xu, Hongjun Yang
Naturally derived fibers such as silk fibroin can potentially enhance the biocompatibility of currently used biomaterials. This study investigated the physical properties of native silk fibroin powder and its effect on the biocompatibility of biomedical polyurethane. Native silk fibroin powder with an average diameter of 3 µm was prepared on a purpose-built machine. A simple method of phase inversion was used to produce biomedical polyurethane/native silk fibroin powder hybrid membranes at different blend ratios by immersing a biomedical polyurethane/native silk fibroin powder solution in deionized water at room temperature...
April 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28322621/bladder-regeneration-using-multiple-acellular-scaffolds-with-growth-factors-in-a-bladder
#19
Luc A J Roelofs, Paul K J D de Jonge, Egbert Oosterwijk, Dorien M Tiemessen, Barbara B M Kortmann, Robert P E de Gier, Elly M M Versteeg, Willeke F Daamen, Toin H van Kuppevelt, Paul J Geutjes, Wout F J Feitz
INTRODUCTION: Tissue engineering may become an alternative to current bladder augmentation techniques. Large scaffolds are needed for clinically significant augmentation, but can result in fibrosis and graft shrinkage. The purpose of this study was to investigate the use of multiple scaffolds instead of one large scaffold, to enhance bladder tissue regeneration and bladder capacity. Second, acellular collagen, collagen-heparin, and collagen-heparin scaffolds with growth factors (GFs) were used and the biological activity of the different scaffolds was compared in a large animal model...
May 2, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28297585/electromechanical-conditioning-of-adult-progenitor-cells-improves-recovery-of-cardiac-function-after-myocardial-infarction
#20
Aida Llucià-Valldeperas, Carolina Soler-Botija, Carolina Gálvez-Montón, Santiago Roura, Cristina Prat-Vidal, Isaac Perea-Gil, Benjamin Sanchez, Ramon Bragos, Gordana Vunjak-Novakovic, Antoni Bayes-Genis
Cardiac cells are subjected to mechanical and electrical forces, which regulate gene expression and cellular function. Therefore, in vitro electromechanical stimuli could benefit further integration of therapeutic cells into the myocardium. Our goals were (a) to study the viability of a tissue-engineered construct with cardiac adipose tissue-derived progenitor cells (cardiac ATDPCs) and (b) to examine the effect of electromechanically stimulated cardiac ATDPCs within a myocardial infarction (MI) model in mice for the first time...
March 2017: Stem Cells Translational Medicine
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