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https://www.readbyqxmd.com/read/28917530/overcoming-key-biological-barriers-to-cancer-drug-delivery-and-efficacy
#1
Susy M Kim, Peggy H Faix, Jan E Schnitzer
Poor delivery efficiency continues to hamper the effectiveness of cancer therapeutics engineered to destroy solid tumors using different strategies such as nanocarriers, targeting agents, and matching treatments to specific genetic mutations. All contemporary anti-cancer agents are dependent upon passive transvascular mechanisms for their delivery into solid tumors. The therapeutic efficacies of our current drug arsenal could be significantly improved with an active delivery strategy. Here, we discuss how drug delivery and therapeutic efficacy is greatly hindered by barriers presented by the vascular endothelial cell layer and by the aberrant nature of tumor blood vessels in general...
September 13, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28915929/the-combination-of-stem-cells-and-tissue-engineering-an-advanced-strategy-for-blood-vessels-regeneration-and-vascular-disease-treatment
#2
REVIEW
Ying Wang, Pei Yin, Guang-Liang Bian, Hao-Yue Huang, Han Shen, Jun-Jie Yang, Zi-Ying Yang, Zhen-Ya Shen
Over the past years, vascular diseases have continued to threaten human health and increase financial burdens worldwide. Transplantation of allogeneic and autologous blood vessels is the most convenient treatment. However, it could not be applied generally due to the scarcity of donors and the patient's condition. Developments in tissue engineering are contributing greatly with regard to this urgent need for blood vessels. Tissue engineering-derived blood vessels are promising alternatives for patients with aortic dissection/aneurysm...
September 15, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28892612/medium-chain-length-polyhydroxyalkanoate-copolymer-modified-by-bacterial-cellulose-for-medical-devices
#3
Denis Mihaela Panaitescu, Irina Lupescu, Adriana Nicoleta Frone, Ioana Chiulan, Cristian Andi Nicolae, Vlad Tofan, Amalia Stefaniu, Raluca Somoghi, Roxana Trusca
Medium chain-length PHAs (mPHAs) are flexible elastomeric biopolymers with valuable properties for biomedical applications like artificial arteries and other medical implants. However, an environmentally friendly and high productivity process together with the tuning of the mechanical and biological properties of mPHAs are mandatory for this purpose. Here, for the first time, a melt processing technique was applied for the preparation of bionanocomposites starting from poly(3-hydroxyoctanoate) (PHO) and bacterial cellulose nanofibers (BC)...
September 11, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28888665/fish-scale-derived-collagen-patch-promotes-growth-of-blood-and-lymphatic-vessels-in-vivo
#4
Jun Kit Wang, Kim Pin Yeo, Yong Yao Chun, Timothy Thatt Yang Tan, Nguan Soon Tan, Véronique Angeli, Cleo Choong
In this study, Type I collagen was extracted from fish scales as a potential alternative source of collagen for tissue engineering applications. Since unmodified collagen typically has poor mechanical and degradation stability both in vitro and in vivo, additional methylation modification and 1,4-butanediol diglycidyl ether (BDE) crosslinking steps were used to improve the physicochemical properties of fish scale-derived collagen. Subsequently, in vivo studies using a murine model demonstrated the biocompatibility of the different fish scale-derived collagen patches...
September 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28875528/transplantation-of-artificial-human-lymphatic-vascular-tissues-fabricated-using-a-cell-accumulation-technique-and-their-engraftment-in-mouse-tissue-with-vascular-remodeling
#5
Yoshiya Asano, Hiroshi Shimoda, Michiya Matsusaki, Mitsuru Akashi
Transplantation of engineered tissues with microvascular structure is advancing towards therapeutic application to improve the flow of blood and/or lymphatic fluids. In lymphatic disorders, transplantation of tissue-engineered lymphatic grafts can be an ideal treatment for draining excessive lymphatic fluid. In this study, we examined the transplantation of three-dimensional artificial human lymphatic network tissue (AHLT) fabricated by the cell accumulation technique into the subcutaneous tissue and fascia of mice...
September 6, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28870749/bioprinting-and-its-applications-in-tissue-engineering-and-regenerative-medicine
#6
REVIEW
Waeljumah Aljohani, Muhammad Wajid Ullah, Xianglin Zhang, Guang Yang
Bioprinting of three-dimensional constructs mimicking natural-like extracellular matrix has revolutionized biomedical technology. Bioprinting technology circumvents various discrepancies associated with current tissue engineering strategies by providing an automated and advanced platform to fabricate various biomaterials through precise deposition of cells and polymers in a premeditated fashion. However, few obstacles associated with development of 3D scaffolds including varied properties of polymers used and viability, controlled distribution, and vascularization, etc...
September 8, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28863041/decellularized-rat-lung-scaffolds-using-sodium-lauryl-ether-sulfate-for-tissue-engineering
#7
Jinhui Ma, Zhihai Ju, Jie Yu, Yeru Qiao, Chenwei Hou, Chen Wang, Feilong Hei
Perfusion decellularization with detergents is effective to maintain the architecture and proteins of extracellular matrix (ECM) for use in the field of lung tissue engineering (LTE). However, it is unclear which detergent is ideal to produce an acellular lung scaffold. In this study, we obtained two decellularized rat lung scaffolds using a novel detergent sodium lauryl ether sulfate (SLES) and a conventional detergent sodium dodecyl sulfate (SDS). Both decellularized lung scaffolds were assessed by histology, immunohistochemistry, scanning electron microscopy, DNA quantification, sulfated glycosaminoglycans (GAGs) quantification and western blot...
August 31, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28860223/differentiation-and-application-of-induced-pluripotent-stem-cell-derived-vascular-smooth-muscle-cells
#8
REVIEW
Eithne Margaret Maguire, Qingzhong Xiao, Qingbo Xu
Vascular smooth muscle cells (VSMCs) play a role in the development of vascular disease, for example, neointimal formation, arterial aneurysm, and Marfan syndrome caused by genetic mutations in VSMCs, but little is known about the mechanisms of the disease process. Advances in induced pluripotent stem cell technology have now made it possible to derive VSMCs from several different somatic cells using a selection of protocols. As such, researchers have set out to delineate key signaling processes involved in triggering VSMC gene expression to grasp the extent of gene regulatory networks involved in phenotype commitment...
August 31, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28857659/cytocompatibility-and-biologic-characteristics-of-synthetic-scaffold-materials-of-rabbit-acellular-vascular-matrix-combining-with-human-like-collagen-i
#9
Xuqian Liu, Jie Wang, Fusheng Dong, Peng Song, Songbo Tian, Hexiang Li, Yali Hou
Scaffold material provides a three-dimensional growing environment for seed cells in the research field of tissue engineering. In the present study, rabbit arterial blood vessel cells were chemically removed with trypsin and Triton X-100 to prepare rabbit acellular vascular matrix scaffold material. Observation by He&Masson staining revealed that no cellular components or nuclei existed in the vascular intima and media after decellularization. Human-like collagen I was combined with acellular vascular matrix by freeze-drying to prepare an acellular vascular matrix-0...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28852429/bioprinted-3d-vascularized-tissue-model-for-drug-toxicity-analysis
#10
Solange Massa, Mahmoud Ahmed Sakr, Jungmok Seo, Praveen Bandaru, Andrea Arneri, Simone Bersini, Elaheh Zare-Eelanjegh, Elmira Jalilian, Byung-Hyun Cha, Silvia Antona, Alessandro Enrico, Yuan Gao, Shabir Hassan, Juan Pablo Acevedo, Mehmet R Dokmeci, Yu Shrike Zhang, Ali Khademhosseini, Su Ryon Shin
To develop biomimetic three-dimensional (3D) tissue constructs for drug screening and biological studies, engineered blood vessels should be integrated into the constructs to mimic the drug administration process in vivo. The development of perfusable vascularized 3D tissue constructs for studying the drug administration process through an engineered endothelial layer remains an area of intensive research. Here, we report the development of a simple 3D vascularized liver tissue model to study drug toxicity through the incorporation of an engineered endothelial layer...
July 2017: Biomicrofluidics
https://www.readbyqxmd.com/read/28844306/signaling-molecules-and-pulp-regeneration
#11
Gottfried Schmalz, Matthias Widbiller, Kerstin M Galler
Signaling molecules play an essential role in tissue engineering because they regulate regenerative processes. Evidence exists from animal studies that single molecules such as members of the transforming growth factor beta superfamily and factors that induce the growth of blood vessels (vascular endothelial growth factor), nerves (brain-derived neurotrophic factor), or fibroblasts (fibroblast growth factor) may induce reparative dentin formation. Mainly the formation of atubular dentin (osteodentin) has been described after the application of single molecules or combinations of recombinant growth factors on healthy exposed pulps or in pulp regeneration...
September 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28843066/deriving-vascular-smooth-muscle-cells-from-mesenchymal-stromal-cells-evolving-differentiation-strategies-and-current-understanding-of-their-mechanisms
#12
REVIEW
Xiaoqing Zhang, Michelle P Bendeck, Craig A Simmons, J Paul Santerre
Vascular smooth muscle cells (VSMCs) play essential roles in regulating blood vessel form and function. Regeneration of functional vascular smooth muscle tissue to repair vascular diseases is an area of intense research in tissue engineering and regenerative medicine. For functional vascular smooth muscle tissue regeneration to become a practical therapy over the next decade, the field will need to have access to VSMC sources that are effective, robust and safe. While pluripotent stem cells hold good future promise to this end, more immediate translation is expected to come from approaches that generate functional VSMCs from adult sources of multipotent adipose-derived and bone marrow-derived mesenchymal stromal cells (ASCs and BMSCs)...
August 15, 2017: Biomaterials
https://www.readbyqxmd.com/read/28831101/growth-differentiation-factor-15-promotes-blood-vessel-growth-by-stimulating-cell-cycle-progression-in-repair-of-critical-sized-calvarial-defect
#13
Shaoyi Wang, Mengyu Li, Wenjie Zhang, Hongfei Hua, Ningtao Wang, Jun Zhao, Jing Ge, Xinquan Jiang, Zhiyuan Zhang, Dongxia Ye, Chi Yang
Repair of large bone defects remains a challenge for surgeons, tissue engineering represents a promising approach. However, the use of this technique is limited by delayed vascularization in central regions of the scaffold. Growth differentiation factor 15(GDF15) has recently been reported to be a potential angiogenic cytokine and has an ability to promote the proliferation of human umbilical vein endothelial cells(HUVECs). Whether it can be applied for promoting vascularized bone regeneration is still unknown...
August 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28817384/engineering-the-mechanical-and-biological-properties-of-nanofibrous-vascular-grafts-for-in-situ-vascular-tissue-engineering
#14
Jeffrey J D Henry, Jian Yu, Aijun Wang, Randall Lee, Jun Fang, Song Li
Synthetic small diameter vascular grafts have a high failure rate, and endothelialization is critical for preventing thrombosis and graft occlusion. A promising approach is in situ tissue engineering, whereby an acellular scaffold is implanted and provides stimulatory cues to guide the in situ remodeling into a functional blood vessel. An ideal scaffold should have sufficient binding sites for biomolecule immobilization and a mechanical property similar to native tissue. Here we developed a novel method to blend low molecular weight (LMW) elastic polymer during electrospinning process to increase conjugation sites and to improve the mechanical property of vascular grafts...
August 17, 2017: Biofabrication
https://www.readbyqxmd.com/read/28811655/a-tissue-engineered-blood-vessel-model-of-hutchinson-gilford-progeria-syndrome-using-human-ipsc-derived-smooth-muscle-cells
#15
Leigh Atchison, Haoyue Zhang, Kan Cao, George A Truskey
Hutchison-Gilford Progeria Syndrome (HGPS) is a rare, accelerated aging disorder caused by nuclear accumulation of progerin, an altered form of the Lamin A gene. The primary cause of death is cardiovascular disease at about 14 years. Loss and dysfunction of smooth muscle cells (SMCs) in the vasculature may cause defects associated with HGPS. Due to limitations of 2D cell culture and mouse models, there is a need to develop improved models to discover novel therapeutics. To address this need, we produced a functional three-dimensional model of HGPS that replicates an arteriole-scale tissue engineered blood vessel (TEBV) using induced pluripotent stem cell (iPSC)-derived SMCs from an HGPS patient...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28802849/silk-fibroin-chitosan-scaffold-with-tunable-properties-and-low-inflammatory-response-assists-the-differentiation-of-bone-marrow-mesenchymal-stem-cells
#16
Da-Wei Li, Xiaohua Lei, Feng-Li He, Jin He, Ya-Li Liu, Ya-Jing Ye, Xudong Deng, Enkui Duan, Da-Chuan Yin
The physical and chemical properties of the scaffold are known to play important roles in three-dimensional (3D) cell culture, which always determine the cellular fate or the results of implantation. To control these properties becomes necessary for meeting the requirements of a variety of tissue engineering applications. In this study, a series of silk fibroin/chitosan (SF/CS) scaffolds with tunable properties were prepared using freeze-drying method, and the rat bone marrow-derived mesenchymal stem cells (BM-MSCs) were seeded in these scaffolds to evaluate their availability of use in tissue engineering...
August 9, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28800593/in-vivo-functional-and-morphological-characterization-of-bone-and-striated-muscle-microcirculation-in-nsg-mice
#17
Haider Mussawy, Lennart Viezens, Gerrit Hauenherm, Malte Schroeder, Christian Schaefer
Organ-specific microcirculation plays a central role in tumor growth, tumor cell homing, tissue engineering, and wound healing. Mouse models are widely used to study these processes; however, these mouse strains often possess unique microhemodynamic parameters, making it difficult to directly compare experiments. The full functional characterization of bone and striated muscle microcirculatory parameters in non-obese diabetic-severe combined immunodeficiency/y-chain; NOD-Prkds IL2rg (NSG) mice has not yet been reported...
2017: PloS One
https://www.readbyqxmd.com/read/28799844/tissue-engineering-the-vascular-tree
#18
Mahama A Traore, Steven C George
A major hurdle in the field of tissue engineering and regenerative medicine remains the design and construction of larger (> 1 cm(3)) in vitro tissues for biological studies and transplantation. While there has been success in creating three-dimensional (3D) capillary networks, relatively large arteries (diameter >3-5 mm), and more recently small arteries (diameter 500 μm-1 mm), there has been no success in the creation of a living dynamic blood vessel network comprising of arterioles (diameter 40-300 μm), capillaries, and venules...
August 11, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28795092/-data-characterizing-microfabricated-human-blood-vessels-created-via-hydrodynamic-focusing
#19
Kyle A DiVito, Michael A Daniele, Steven A Roberts, Frances S Ligler, André A Adams
This data article provides further detailed information related to our research article titled "Microfabricated Blood Vessels Undergo Neovascularization" (DiVito et al., 2017) [1], in which we report fabrication of human blood vessels using hydrodynamic focusing (HDF). Hydrodynamic focusing with advection inducing chevrons were used in concert to encase one fluid stream within another, shaping the inner core fluid into 'bullseye-like" cross-sections that were preserved through click photochemistry producing streams of cellularized hollow 3-dimensional assemblies, such as human blood vessels (Daniele et al...
October 2017: Data in Brief
https://www.readbyqxmd.com/read/28783156/hydrogels-with-precisely-controlled-integrin-activation-dictate-vascular-patterning-and%C3%A2-permeability
#20
Shuoran Li, Lina R Nih, Haylee Bachman, Peng Fei, Yilei Li, Eunwoo Nam, Robert Dimatteo, S Thomas Carmichael, Thomas H Barker, Tatiana Segura
Integrin binding to bioengineered hydrogel scaffolds is essential for tissue regrowth and regeneration, yet not all integrin binding can lead to tissue repair. Here, we show that through engineering hydrogel materials to promote α3/α5β1 integrin binding, we can promote the formation of a space-filling and mature vasculature compared with hydrogel materials that promote αvβ3 integrin binding. In vitro, α3/α5β1 scaffolds promoted endothelial cells to sprout and branch, forming organized extensive networks that eventually reached and anastomosed with neighbouring branches...
September 2017: Nature Materials
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