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https://www.readbyqxmd.com/read/29128537/biomaterials-for-articular-cartilage-tissue-engineering-learning-from-biology
#1
REVIEW
A R Armiento, M J Stoddart, M Alini, D Eglin
Articular cartilage is commonly described as a tissue made of up to 80% water, devoid of blood vessels, nerves and lymphatics, and populated by only one cell type: at first glance, an easy tissue for clinicians to repair and for scientists to reproduce in a laboratory. Yet, chondral and osteochondral defects currently remain an open challenge in orthopedics and tissue engineering of the musculoskeletal system, without considering osteoarthritis. Why do we fail in repairing and regenerating articular cartilage? Behind its simple and homogenous appearance articular cartilage hides a heterogeneous composition, a high level of organisation and specific biomechanical properties that taken together make articular cartilage a unique material that we are not able yet to repair or reproduce with high fidelity...
November 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29127293/three-dimensional-printed-polylactic-acid-hydroxyapatite-composite-scaffolds-for-prefabricating-vascularized-tissue-engineered-bone-an-in-vivo-bioreactor-model
#2
Haifeng Zhang, Xiyuan Mao, Danyang Zhao, Wenbo Jiang, Zijing Du, Qingfeng Li, Chaohua Jiang, Dong Han
The repair of large bone defects with complex geometries remains a major clinical challenge. Here, we explored the feasibility of fabricating polylactic acid-hydroxyapatite (PLA-HA) composite scaffolds. These scaffolds were constructed from vascularized tissue engineered bone using an in vivo bioreactor (IVB) strategy with three-dimensional printing technology. Specifically, a rabbit model was established to prefabricate vascularized tissue engineered bone in two groups. An experimental group (EG) was designed using a tibial periosteum capsule filled with 3D printed (3DP) PLA-HA composite scaffolds seeded with bone marrow stromal cells (BMSCs) and crossed with a vascular bundle...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29119674/assessment-of-hydrogels-for-bioprinting-of-endothelial-cells
#3
Leo Benning, Ludwig Gutzweiler, Kevin Tröndle, Julian Riba, Roland Zengerle, Peter Koltay, Stefan Zimmermann, G Björn Stark, Günter Finkenzeller
In tissue engineering applications, vascularization can be accomplished by co-implantation of tissue forming cells and endothelial cells (ECs), whereby the latter are able to form functional blood vessels. The use of three-dimensional (3D) bioprinting technologies has the potential to improve the classical tissue engineering approach because these will allow the generation of scaffolds with high spatial control of endothelial cell allocation. This study focuses on a side by side comparisons of popular commercially available bioprinting hydrogels (matrigel, fibrin, collagen, gelatin, agarose, Pluronic F-127, alginate and alginate/gelatin) in the context of their physicochemical parameters, their swelling/degradation characteristics, their biological effects on vasculogenesis-related EC parameters and their printability...
November 8, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29105392/mouse-bone-marrow-derived-mast-cells-induce-angiogenesis-by-tissue-engineering-in-rats-histological-evidence
#4
Ali Karimi, Rasoul Shahrooz, Rahim Hobbenaghi, Rahim Mohammadi, Esmaeil Mortaz
OBJECTIVES: Therapeutic angiogenesis is employed to induce vascular network formation and improve functional recovery in ischemia. The aim of this study is to find an appropriate method to recover local ischemic conditions. MATERIALS AND METHODS: In this experimental survey, 20 male Wistar rats weighing approximately 200-250 g were randomly divided into four experimental groups respectively: ischemia group in which the femoral artery was transected; phosphate buffer solution group (PBS) in which the femoral artery transected location was immersed with PBS; chitosan (CHIT) group in which the transected location was immersed in a 50 μL CHIT solution; and mast cell transplanted group in which the transected location was immersed with a mixture of 50 μL CHIT and 50 μL PBS that contained 1×10(6) mast cells...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29099989/tissue-engineered-regenerating-blood-vessels-restoring-the-body-s-circulation-with-regenerating-blood-vessels-a-reality
#5
Maximilian Y Emmert
No abstract text is available yet for this article.
November 1, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29081492/tissue-engineered-small-vessel-conduits-the-anti-thrombotic-effect-of-re-endothelialization-of-decellularized-baboon-arteries-a-preliminary-experimental-study
#6
Muriel Meiring, Mmakgabu Khemisi, Leana Laker, Pascal M Dohmen, Francis E Smit
BACKGROUND The use of decellularized biological scaffolds for the reconstruction of small-diameter vascular grafts remains a challenge in tissue engineering. Thrombogenicity is an important cause of obstruction in these vessels due to decellularization. Seeding of the decellularized vascular constructs with endothelial cells is therefore a prerequisite for the prevention of thrombosis. The aim of this study was to seed decellularized baboon arteries with endothelial cells and to compare the thrombogenicity to that of decellularized arteries after circulation of blood...
October 30, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/29076411/peptides-and-their-metal-complexes-in-neurodegenerative-diseases-from-structural-studies-to-nanomedicine-prospects
#7
Giuseppe Trapani, Cristina Satriano, Diego La Mendola
Metal ions dyshomeostasis is increasingly recognized to play a crucial role in the development of aging-related neurodegenerative diseases. Metal trafficking in the brain is related to the proteins that regulate the uptake and efflux of metals in neurons. Different pathways may occur depending on specific binding features of metallo-protein complexes, such as conformational changes, redox processes and aggregates formation. Specifically, copper, zinc and iron are recognized to influence the biochemistry of proteins involved in neurodegeneration, including A, prions, -synuclein and, among others, neurotrophins, crucial in neuronal development and efficiency...
October 26, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29059482/bioinspired-nanocomposite-hydrogels-with-highly-ordered-structures
#8
REVIEW
Ziguang Zhao, Ruochen Fang, Qinfeng Rong, Mingjie Liu
In the human body, many soft tissues with hierarchically ordered composite structures, such as cartilage, skeletal muscle, the corneas, and blood vessels, exhibit highly anisotropic mechanical strength and functionality to adapt to complex environments. In artificial soft materials, hydrogels are analogous to these biological soft tissues due to their "soft and wet" properties, their biocompatibility, and their elastic performance. However, conventional hydrogel materials with unordered homogeneous structures inevitably lack high mechanical properties and anisotropic functional performances; thus, their further application is limited...
October 23, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29035553/construction-of-antithrombotic-tissue-engineered-blood-vessel-via-reduced-graphene-oxide-based-dual-enzyme-biomimetic-cascade
#9
Da Huo, Ge Liu, Yanzhao Li, Yuxin Wang, Ge Guan, Mingcan Yang, Keyu Wei, Jingyuan Yang, Lingqin Zeng, Gang Li, Wen Zeng, Chuhong Zhu
Thrombosis is one of the biggest obstacles in the clinical application of small-diameter tissue-engineered blood vessels (TEBVs). The implantation of an unmodified TEBV will lead to platelet aggregation and further activation of the coagulation cascade, in which the high concentration of adenosine diphosphate (ADP) that is released by platelets plays an important role. Inspired by the phenomenon that endothelial cells continuously generate endogenous antiplatelet substances via enzymatic reactions, we designed a reduced graphene oxide (RGO) based dual-enzyme biomimetic cascade to successively convert ADP into adenosine monophosphate (AMP) and AMP into adenosine...
October 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/29033499/fabrication-and-characterization-of-electrospun-thermoplastic-polyurethane-fibroin-small-diameter-vascular-grafts-for-vascular-tissue-engineering
#10
E Yu, J Zhang, J A Thomson, L-S Turng
The demand for small-diameter blood vessel substitutes has been increasing due to a shortage of autograft vessels and problems with thrombosis and intimal hyperplasia with synthetic grafts. In this study, hybrid small-diameter vascular grafts made of thermoplastic polyurethane (TPU) and silk fibroin, which possessed a hybrid fibrous structure of an aligned inner layer and a random outer layer, were fabricated by the electrospinning technique using a customized striated collector that generated both aligned and random fibers simultaneously...
November 2016: Int Polym Process
https://www.readbyqxmd.com/read/29025640/fabrication-and-preliminary-study-of-a-biomimetic-tri-layer-tubular-graft-based-on-fibers-and-fiber-yarns-for-vascular-tissue-engineering
#11
Tong Wu, Jialing Zhang, Yuanfei Wang, Dandan Li, Binbin Sun, Hany El-Hamshary, Meng Yin, Xiumei Mo
Designing a biomimetic and functional tissue-engineered vascular graft has been urgently needed for repairing and regenerating defected vascular tissues. Utilizing a multi-layered vascular scaffold is commonly considered an effective way, because multi-layered scaffolds can easily simulate the structure and function of natural blood vessels. Herein, we developed a novel tri-layer tubular graft consisted of Poly(L-lactide-co-caprolactone)/collagen (PLCL/COL) fibers and Poly(lactide-co-glycolide)/silk fibroin (PLGA/SF) yarns via a three-step electrospinning method...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28994225/scaffold-composition-determines-the-angiogenic-outcome-of-cell-based-vascular-endothelial-growth-factor-expression-by-modulating-its-microenvironmental-distribution
#12
Emanuele Gaudiello, Ludovic Melly, Giulia Cerino, Stefano Boccardo, Sasan Jalili-Firoozinezhad, Lifen Xu, Friedrich Eckstein, Ivan Martin, Beat A Kaufmann, Andrea Banfi, Anna Marsano
Delivery of genetically modified cells overexpressing Vascular Endothelial Growth Factor (VEGF) is a promising approach to induce therapeutic angiogenesis in ischemic tissues. The effect of the protein is strictly modulated by its interaction with the components of the extracellular matrix. Its therapeutic potential depends on a sustained but controlled release at the microenvironmental level in order to avoid the formation of abnormal blood vessels. In this study, it is hypothesized that the composition of the scaffold plays a key role in modulating the binding, hence the therapeutic effect, of the VEGF released by 3D-cell constructs...
October 10, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28990632/the-use-of-rgd-engineered-exosomes-for-enhanced-targeting-ability-and-synergistic-therapy-toward-angiogenesis
#13
Jie Wang, Wei Li, Zhichao Lu, Leicheng Zhang, Yu Hu, Qiubai Li, Wei Du, Xiaojun Feng, Haibo Jia, Bi-Feng Liu
Promoted therapeutic angiogenesis is a major objective in the area of regenerative medicine, and sufficient vascularization of artificial tissues or organs is one of the main difficulties for the realization of tissue engineering methods. The identification of new kinds of pro-angiogenic materials will greatly profit developments in regenerative medicine. The use of exosomes for this intention is a considerably new idea developed in recent years. However, several limitations need to be addressed before their use as clinical therapeutics, including the lack of efficient exosome enrichment and methods to endow exosomes with targeting ability...
October 19, 2017: Nanoscale
https://www.readbyqxmd.com/read/28987783/engineering-fibrin-hydrogels-to-promote-the-wound-healing-potential-of-mesenchymal-stem-cell-spheroids
#14
Kaitlin C Murphy, Jacklyn Whitehead, Dejie Zhou, Steve S Ho, J Kent Leach
Mesenchymal stem cells (MSCs) secrete endogenous factors such as vascular endothelial growth factor (VEGF) and prostaglandin E2 (PGE2) that promote angiogenesis, modulate the inflammatory microenvironment, and stimulate wound repair, and MSC spheroids secrete more trophic factors than dissociated, individual MSCs. Compared to injection of cells alone, transplantation of MSCs in a biomaterial can enhance their wound healing potential by localizing cells at the defect site and upregulating trophic factor secretion...
December 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28981128/modeling-angiogenesis-with-micro-and-nanotechnology
#15
REVIEW
Li-Jiun Chen, Hirokazu Kaji
Angiogenesis plays an important role not only in the growth and regeneration of tissues in humans but also in pathological conditions such as inflammation, degenerative disease and the formation of tumors. Angiogenesis is also vital in thick engineered tissues and constructs, such as those for the heart and bone, as these can face difficulties in successful implantation if they are insufficiently vascularized or unable to connect to the host vasculature. Considerable research has been carried out on angiogenic processes using a variety of approaches...
October 5, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28978275/low-immunogenic-endothelial-cells-maintain-morphofunctional-properties-needed-for-tissue-engineering
#16
Skadi Lau, Dorothee Eicke, Marco Carvalho Oliveira, Bettina Wiegmann, Claudia Schrimpf, Axel Haverich, Rainer Blasczyk, Mathias Wilhelmi, Constanςa Figueiredo, Ulrike Böer
The limited availability of native vessels suitable for the application as hemodialysis shunts or bypass material demands new strategies in cardiovascular surgery. Tissue engineered vascular grafts containing autologous cells are considered as ideal vessel replacements due to the low risk of rejection. However, endothelial cells (EC), which are central components of natural blood vessels, are difficult to obtain from elderly patients of poor health. Umbilical cord blood represents a promising alternative source for EC but their allogeneic origin corresponds with the risk of rejection after allotransplantation...
October 5, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28976521/cardiac-microphysiological-devices-with-flexible-thin-film-sensors-for-higher-throughput-drug-screening
#17
Johan U Lind, Moran Yadid, Ian Perkins, Blakely B O'Connor, Feyisayo Eweje, Christophe O Chantre, Matthew A Hemphill, Hongyan Yuan, Patrick H Campbell, Joost J Vlassak, Kevin K Parker
Microphysiological systems and organs-on-chips promise to accelerate biomedical and pharmaceutical research by providing accurate in vitro replicas of human tissue. Aside from addressing the physiological accuracy of the model tissues, there is a pressing need for improving the throughput of these platforms. To do so, scalable data acquisition strategies must be introduced. To this end, we here present an instrumented 24-well plate platform for higher-throughput studies of engineered human stem cell-derived cardiac muscle tissues that recapitulate the laminar structure of the native ventricle...
October 25, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28969687/metabolically-conditioned-media-derived-from-bone-marrow-stromal-cells-or-human-skin-fibroblasts-act-as-effective-chemoattractants-for-mesenchymal-stem-cells
#18
Anastasia Gabrielyan, Elena Neumann, Michael Gelinsky, Angela Rösen-Wolff
BACKGROUND: The main goal of bone tissue engineering has been the generation of healthy bone in order to replace affected tissue. Therefore, optimized biomaterials are needed which allow the survival and growth of mesenchymal stem cells. Until now the key challenge in the clinical application of cell-based tissue engineering bone implants was poor diffusion of oxygen into the tissue, making functional blood vessel networks a necessity. With their ability to evolve into different cell types, to expand extensively in vitro, and to release paracrine soluble factors, bone marrow stromal cells (BMSC) are highly attractive for tissue engineering...
September 29, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28956678/preparation-and-characterization-of-polycaprolactone-polyethylene-glycol-methyl-ether-and-polycaprolactone-chitosan-electrospun-mats-potential-for-vascular-tissue-engineering
#19
Tamanna Sultana, Jhaleh Amirian, Chanmi Park, Seung Jin Lee, Byong-Taek Lee
Recently, natural polymers are frequently comingled with synthetic polymers either by physical or chemical modification to prepare numerous tissue-engineered graft with promising biological function, strength, and stability. The aim of this study was to determine the efficiency for vascular tissue engineering of two distinctly different mats, one that comprised polycaprolactone-polyethylene glycol methyl ether and other that comprised polycaprolactone-chitosan. Nano/microfibrous mats prepared from electro-spinning were characterized for fiber diameter, porosity, wettability, and mechanical strength...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28942575/a-contact-based-method-for-differentiation-of-human-mesenchymal-stem-cells-into-an-endothelial-cell-phenotype
#20
Binata Joddar, Shweta Anil Kumar, Alok Kumar
Adult stem cells such as mesenchymal stem cells (MSC) are known to possess the ability to augment neovascularization processes and are thus widely popular as an autologous source of progenitor cells. However there is a huge gap in our current knowledge of mechanisms involved in differentiating MSC into endothelial cells (EC), essential for lining engineered blood vessels. To fill up this gap, we attempted to differentiate human MSC into EC, by culturing the former onto chemically fixed layers of EC or its ECM, respectively...
September 23, 2017: Cell Biochemistry and Biophysics
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