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tissue engineered blood vessel

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https://www.readbyqxmd.com/read/28093366/strategy-for-constructing-vascularized-adipose-units-in-poly-l-glutamic-acid-hydrogel-porous-scaffold-through-inducing-in-situ-formation-of-ascs-spheroids
#1
Kunxi Zhang, Li Song, Jia Wang, Shifeng Yan, Guifei Li, Lei Cui, Jingbo Yin
: Vascularization is of great importance to adipose tissue regeneration. Here we introduced a paradigm that using scaffold to induce ASC spheroids, so to promote vascularized adipose tissue regeneration. Poly (L-glutamic acid) (PLGA) was activated by EDC, followed by being cross-linked by Adipic dihydrazide (ADH) to form a homogeneous hydrogel. Lyophilization was then carried out to create porous structure. The PLGA hydrogel scaffold possessed a significant swollen hydrophilic network to weaken cell-scaffold adhesion but drive ASCs to aggregate to form spheroids...
January 13, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28092776/periosteum-tissue-engineering-in-an-orthotopic-in%C3%A2-vivo-platform
#2
J G Baldwin, F Wagner, L C Martine, B M Holzapfel, C Theodoropoulos, O Bas, F M Savi, C Werner, E M De-Juan-Pardo, D W Hutmacher
The periosteum plays a critical role in bone homeostasis and regeneration. It contains a vascular component that provides vital blood supply to the cortical bone and an osteogenic niche that acts as a source of bone-forming cells. Periosteal grafts have shown promise in the regeneration of critical size defects, however their limited availability restricts their widespread clinical application. Only a small number of tissue-engineered periosteum constructs (TEPCs) have been reported in the literature. A current challenge in the development of appropriate TEPCs is a lack of pre-clinical models in which they can reliably be evaluated...
November 20, 2016: Biomaterials
https://www.readbyqxmd.com/read/28070690/reconstruction-of-defects-of-the-trachea
#3
Margot Den Hondt, Jan Jeroen Vranckx
The trachea has a complex anatomy to fulfill its tasks. Its unique fibro-cartilaginous structure maintains an open conduit during respiration, and provides vertical elasticity for deglutition, mobility of the neck and speech. Blood vessels pierce the intercartilaginous ligaments to perfuse the ciliated epithelium, which ensures effective mucociliary clearance. Removal of a tracheal segment affected by benign or malignant disease requires airtight restoration of the continuity of the tube. When direct approximation of both tracheal ends is no longer feasible, a reconstruction is needed...
February 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28069505/end-point-immobilization-of-heparin-on-plasma-treated-surface-of-electrospun-polycarbonate-urethane-vascular-graft
#4
Xuefeng Qiu, Benjamin Li-Ping Lee, Xinghai Ning, Niren Murthy, Nianguo Dong, Song Li
: Small-diameter synthetic vascular grafts have high failure rate due to primarily surface thrombogenicity, and effective surface chemical modification is critical to maintain the patency of the grafts. In this study, we engineered a small-diameter, elastic synthetic vascular graft with off-the-shelf availability and anti-thrombogenic activity. Polycarbonate-urethane (PCU), was electrospun to produce nanofibrous grafts that closely mimicked a native blood vessel in terms of structural and mechanical strength...
January 6, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28052540/engineered-neural-tissue-with-schwann-cell-differentiated-human-dental-pulp-stem-cells-potential-for-peripheral-nerve-repair
#5
Kathleen Sanen, Wendy Martens, Melanie Georgiou, Marcel Ameloot, Ivo Lambrichts, James Phillips
Despite the spontaneous regenerative capacity of the peripheral nervous system, large gap peripheral nerve injuries (PNIs) require bridging strategies. The limitations and suboptimal results obtained with autografts or hollow nerve conduits in the clinic urge the need for alternative treatments. Recently, we have described promising neuroregenerative capacities of Schwann cells derived from differentiated human dental pulp stem cells (d-hDPSCs) in vitro. Here, we extended the in vitro assays to show the pro-angiogenic effects of d-hDPSCs, such as enhanced endothelial cell proliferation, migration and differentiation...
January 4, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28038405/comprehensive-mechanical-characterization-of-pla-fabric-combined-with-pcl-to-form-a-composite-structure-vascular-graft
#6
Chaojing Li, Fujun Wang, Graeham Douglas, Ze Zhang, Robert Guidoin, Lu Wang
Vascular grafts made by tissue engineering processes are prone to buckling and twisting, which can impede blood flow and lead to collapse of the vessel. These vascular conduits may suffer not only from insufficient tensile strength, but also from vulnerabilities related to compression, torsion, and pulsatile pressurization. Aiming to develop a tissue engineering-inspired blood conduit, composite vascular graft (cVG) prototypes were created by combining a flexible polylactic acid (PLA) knitted fabric with a soft polycaprolactone (PCL) matrix...
December 15, 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28029246/synergetic-cues-of-bioactive-nanoparticles-and-nanofibrous-structure-in-bone-scaffolds-to-stimulate-osteogenesis-and-angiogenesis
#7
Jung-Ju Kim, Ahmed El-Fiqi, Hae-Won Kim
Providing a nanotopological physical cue in concert with a bioactive chemical signal within 3D scaffolds, while it is being considered a promising approach for bone regeneration, has yet to be explored. Here, we develop 3D porous scaffolds that are networked to be a nanofibrous structure and incorporated with bioactive glass nanoparticles (BGn) to tackle this issue. The involvement of BGn and nanofibrous structure (BGn+nanofibrous) substantially increased the surface area, hydro-affinity and protein loading capacity of scaffolds...
December 28, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28024596/laminated-electrospun-nha-phb-composite-scaffolds-mimicking-bone-extracellular-matrix-for-bone-tissue-engineering
#8
Zhuoyue Chen, Yue Song, Jing Zhang, Wei Liu, Jihong Cui, Hongmin Li, Fulin Chen
Electrospinning is an effective means to generate nano- to micro-scale polymer fibers resembling native extracellular matrix for tissue engineering. However, a major problem of electrospun materials is that limited pore size and porosity may prevent adequate cellular infiltration and tissue ingrowth. In this study, we first prepared thin layers of hydroxyapatite nanoparticle (nHA)/poly-hydroxybutyrate (PHB) via electrospinning. We then laminated the nHA/PHB thin layers to obtain a scaffold for cell seeding and bone tissue engineering...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27999795/in-vivo-remodeling-of-fibroblast-derived-vascular-scaffolds-implanted-for-6-months-in-rats
#9
Maxime Y Tondreau, Véronique Laterreur, Karine Vallières, Robert Gauvin, Jean-Michel Bourget, Catherine Tremblay, Dan Lacroix, Lucie Germain, Jean Ruel, Francois A Auger
There is a clinical need for tissue-engineered small-diameter (<6 mm) vascular grafts since clinical applications are halted by the limited suitability of autologous or synthetic grafts. This study uses the self-assembly approach to produce a fibroblast-derived decellularized vascular scaffold (FDVS) that can be available off-the-shelf. Briefly, extracellular matrix scaffolds were produced using human dermal fibroblasts sheets rolled around a mandrel, maintained in culture to allow for the formation of cohesive and three-dimensional tubular constructs, and decellularized by immersion in deionized water...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27998245/generation-endothelialization-and-microsurgical-suture-anastomosis-of-strong-1-mm-diameter-collagen-tubes
#10
Xuanyue Li, Jing Xu, Calin T Nicolescu, Jordann T Marinelli, Joe Tien
Tissue-engineered vascular grafts that are based on reconstituted extracellular matrices have been plagued by weak mechanical strength that prevents handling or anastomosis to native vessels. In this study, we devise a method for making dense, suturable collagen tubular constructs of diameter ≤1 mm for potential microsurgical applications, by dehydrating tubes of native rat tail type I collagen and crosslinking them with 20 mM genipin. Crosslinked dense collagen tubes with 1 mm inner diameter yielded ultimate tensile strength of 342 ± 15 gF and burst pressure of 1313 ± 156 mm Hg, comparable to the strength of a rat femoral artery, and supported endothelial cell adhesion and growth...
January 13, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27988406/diabetes-impairs-arterio-venous-specification-in-engineered-vascular-tissues-in-a-perivascular-cell-recruitment-dependent-manner
#11
Wafa Altalhi, Xuetao Sun, Jeremy M Sivak, Mansoor Husain, Sara S Nunes
Cell-based tissue engineering is a potential treatment alternative for organ replacement. However, the lack of a robust vasculature, especially in the context of diseases such as diabetes, is a major hindrance to its success. Despite extensive research on the effects of diabetes in angiogenic sprouting, its effects on vessel arterio-venous (AV) specification have not been addressed. Using an engineered tissue that yields functional vessels with characteristic AV identities, we demonstrate that type 1 diabetes negatively affects vessel AV specification and perivascular cell (PVC) coverage...
March 2017: Biomaterials
https://www.readbyqxmd.com/read/27987825/a-composite-chitosan-gelatin-bi-layered-biomimetic-macroporous-scaffold-for-blood-vessel-tissue-engineering
#12
Ravindra V Badhe, Divya Bijukumar, Dharmesh R Chejara, Mostafa Mabrouk, Yahya E Choonara, Pradeep Kumar, Lisa C du Toit, Pierre P D Kondiah, Viness Pillay
A composite chitosan-gelatin macroporous hydrogel-based scaffold with bi-layered tubular architecture was engineered by solvent casting-co-particulate leaching. The scaffold constituted an inner macroporous layer concealed by a non-porous outer layer mimicking the 3D matrix of blood vessels with cellular adhesion and proliferation. The scaffold was evaluated for its morphological, physicochemical, physicomechanical and biodurability properties employing SEM, FTIR, DSC, XRD, porositometry, rheology and texture analysis...
February 10, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27987787/electrospun-polycaprolactone-gelatin-composites-with-enhanced-cell-matrix-interactions-as-blood-vessel-endothelial-layer-scaffolds
#13
Yong-Chao Jiang, Lin Jiang, An Huang, Xiao-Feng Wang, Qian Li, Lih-Sheng Turng
During the fabrication of tissue engineering scaffolds and subsequent tissue regeneration, surface bioactivity is vital for cell adhesion, spreading, and proliferation, especially for endothelium dysfunction repair. In this paper, synthetic polymer polycaprolactone (PCL) was blended with natural polymer gelatin at four different weight ratios followed by crosslinking (i.e., 100:0, 70:30, 50:50, 30:70, labeled as PCL-C, P7G3-C, P5G5-C, and P3G7-C) to impart enhanced bioactivity and tunable mechanical properties...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27981886/additive-manufacturing-of-vascular-grafts-and-vascularized-tissue-constructs
#14
Laura Elomaa, Yunzhi Peter Yang
There is a great need for engineered vascular grafts among patients with cardiovascular diseases who are in need of bypass therapy and lack autologous healthy blood vessels. In addition, because of the severe worldwide shortage of organ donors, there is an increasing need for engineered vascularized tissue constructs as an alternative to organ transplants. Additive manufacturing (AM) offers great advantages and flexibility of fabrication of cell-laden, multimaterial, and anatomically shaped vascular grafts and vascularized tissue constructs...
January 10, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27965914/computational-model-based-analysis-of-strategies-to-enhance-scaffold-vascularization
#15
Elif Seyma Bayrak, Banu Akar, Sami I Somo, Chenlin Lu, Nan Xiao, Eric M Brey, Ali Cinar
Stable and extensive blood vessel networks are required for cell function and survival in engineered tissues. A number of different strategies are currently being investigated to enhance biomaterial vascularization with screening primarily through extensive in vitro and in vivo experiments. In this article, we describe an agent-based model (ABM) developed to evaluate various strategies in silico, including design of optimal biomaterial structure, delivery of angiogenic factors, and application of prevascularized biomaterials...
2016: BioResearch Open Access
https://www.readbyqxmd.com/read/27959397/engineering-of-the-human-vessel-wall-with-hair-follicle-stem-cells-in-vitro
#16
Zhi-Cheng Xu, Qun Zhang, Hong Li
Hair follicle stem cells (HFSCs) are increasingly used as a stem cell paradigm in vascular tissue engineering due to the fact that they are a rich source of easily accessible multipotent adult stem cells. Promising results have been demonstrated with small diameter (less than 6 mm) tissue engineered blood vessels under low blood pressure, however engineering large vessels (>6 mm in diameter) remains a challenge due to the fact it demands a higher number of seed cells and higher quality biomechanical properties...
January 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27956360/defining-the-hierarchical-organisation-of-collagen-vi-microfibrils-at-nanometre-to-micrometre-length-scales
#17
Alan R F Godwin, Tobias Starborg, Michael J Sherratt, Alan M Roseman, Clair Baldock
: Extracellular matrix microfibrils are critical components of connective tissues with a wide range of mechanical and cellular signalling functions. Collagen VI is a heteromeric network-forming collagen which is expressed in tissues such as skin, lung, blood vessels and articular cartilage where it anchors cells into the matrix allowing for transduction of biochemical and mechanical signals. It is not understood how collagen VI is arranged into microfibrils or how these microfibrils are arranged into tissues...
December 10, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27936727/targeting-heparin-to-collagen-within-extracellular-matrix-significantly-reduces-thrombogenicity-and-improves-endothelialization-of-decellularized-tissues
#18
Bin Jiang, Rachel Suen, Jason A Wertheim, Guillermo A Ameer
Thrombosis within small-diameter vascular grafts limits the development of bioartificial, engineered vascular conduits, especially those derived from extracellular matrix (ECM). Here we describe an easy-to-implement strategy to chemically modify vascular ECM by covalently linking a collagen binding peptide (CBP) to heparin to form a heparin derivative (CBP-heparin) that selectively binds a subset of collagens. Modification of ECM with CBP-heparin leads to increased deposition of functional heparin (by ∼7...
12, 2016: Biomacromolecules
https://www.readbyqxmd.com/read/27934785/influence-of-hydroxyl-terminated-polydimethylsiloxane-on-high-strength-biocompatible-polycarbonate-urethane-films
#19
Rong Zhu, Xinyu Wang, Jing Yang, Yiyu Wang, Zongrui Zhang, Yuanjing Hou, Fei Lin
The present study describes a series of novel polycarbonate urethane films that were fabricated via the solution-casting method from 4,4'-methylenebis(cyclohexyl isocyanate) (H12MDI) and 1,4-butanediol (BDO) chain extender as hard segments, poly(1,6-hexanediol)carbonate diols (PCDL) and hydroxyl-terminated polydimethylsiloxane (PDMS) as soft segments, with dibutyltin dilaurate as the catalyst. Varied molar ratios of PDMS (less than 30%) were utilized to enhance the mechanical properties and biocompatibilities...
December 9, 2016: Biomedical Materials
https://www.readbyqxmd.com/read/27918018/a-planar-model-of-the-vessel-wall-from-cellularized-collagen-scaffolds-focus-on-cell-matrix-interactions-in-mono-bi-and-tri-culture-models
#20
Caroline Loy, Sébastien Meghezi, Lucie Lévesque, Daniele Pezzoli, Heena Kumra, Dieter Reinhardt, Jayachandran N Kizhakkedathu, Diego Mantovani
The acquisition of new thorough knowledge on the interactions existing between vascular cells would represent a step forward in the engineering of vascular tissues. In this light, herein we designed a physiological-like tri-culture in vitro vascular wall model using a planar cellularized collagen gel as the scaffold. The model can be obtained in 24 h and features multi-layered hierarchical organization composed of a fibroblast-containing adventitia-like layer, a media-like layer populated by smooth muscle cells and an intima-like endothelial cell monolayer...
December 20, 2016: Biomaterials Science
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