keyword
MENU ▼
Read by QxMD icon Read
search

tissue engineered blood vessel

keyword
https://www.readbyqxmd.com/read/28547766/local-release-of-vegf-using-fiber-mats-enables-effective-transplantation-of-layered-cardiomyocyte-sheets
#1
Kenichi Nagase, Yuhei Nagumo, Miri Kim, Hee-Jung Kim, Hei-Won Kyung, Hye-Jin Chung, Hidekazu Sekine, Tatsuya Shimizu, Hideko Kanazawa, Teruo Okano, Seung-Jin Lee, Masayuki Yamato
Cell sheet transplantation is a key tissue engineering technology. A vascular endothelial growth factor (VEGF)-releasing fiber mat is developed for the transplantation of multilayered cardiomyocyte sheets. Poly(vinyl alcohol) fiber mats bearing poly(lactic-co-glycolic acid) nanoparticles that incorporate VEGF are fabricated using electrospinning and electrospray methods. Six-layered cardiomyocyte sheets are transplanted with a VEGF-releasing mat into athymic rats. After two weeks, these sheets produce thicker cardiomyocyte layers compared with controls lacking a VEGF-releasing mat, and incorporate larger-diameter blood vessels containing erythrocytes...
May 26, 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/28546952/time-dependency-of-morphological-remodeling-of-endothelial-cells-in-response-to-substrate-stiffness
#2
Zahra Goli-Malekabadi, Mohammad Tafazzoli-Shadpour, Ali Tamayol, Ehsan Seyedjafari
Introduction: Substrate stiffness regulates cellular behavior as cells experience different stiffness values of tissues in the body. For example, endothelial cells (ECs) covering the inner layer of blood vessels are exposed to different stiffness values due to various pathologic and physiologic conditions. Despite numerous studies, cells by time span sense mechanical properties of the substrate, but the response is not well understood. We hypothesized that time is a major determinant influencing the behavior of cells seeded on substrates of varying stiffness...
2017: BioImpacts: BI
https://www.readbyqxmd.com/read/28524375/bioprinted-osteogenic-and-vasculogenic-patterns-for-engineering-3d-bone-tissue
#3
Batzaya Byambaa, Nasim Annabi, Kan Yue, Grissel Trujillo-de Santiago, Mario Moisés Alvarez, Weitao Jia, Mehdi Kazemzadeh-Narbat, Su Ryon Shin, Ali Tamayol, Ali Khademhosseini
Fabricating 3D large-scale bone tissue constructs with functional vasculature has been a particular challenge in engineering tissues suitable for repairing large bone defects. To address this challenge, an extrusion-based direct-writing bioprinting strategy is utilized to fabricate microstructured bone-like tissue constructs containing a perfusable vascular lumen. The bioprinted constructs are used as biomimetic in vitro matrices to co-culture human umbilical vein endothelial cells and bone marrow derived human mesenchymal stem cells in a naturally derived hydrogel...
May 19, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28513058/pro-myogenic-and-low-oxygen-culture-increases-expression-of-contractile-smooth-muscle-markers-in-human-fibroblasts
#4
Matija Veber, David Dolivo, Marsha Rolle, Tanja Dominko
Smooth muscle cells are essential for tissue engineering strategies to fabricate organs such as blood vessels, esophagus, and bladder, and to create disease models of these systems. In order for such therapies and models to be feasible, smooth muscle cells must be sourced effectively to enable production of large numbers of functional cells. In vitro, smooth muscle cells divide slowly and demonstrate short proliferative lifespans compared to other types of cells including stem cells and fibroblasts, limiting the number of cells that can be derived from expansion in culture of a primary isolation...
May 17, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28495397/safety-profile-and-long-term-engraftment-of-human-cd31-blood-progenitors-in-bone-tissue-engineering
#5
Hadar Zigdon-Giladi, Rina Elimelech, Gal Michaeli-Geller, Utai Rudich, Eli E Machtei
BACKGROUND: Endothelial progenitor cells (EPCs) participate in angiogenesis and induce favorable micro-environments for tissue regeneration. The efficacy of EPCs in regenerative medicine is extensively studied; however, their safety profile remains unknown. Therefore, our aims were to evaluate the safety profile of human peripheral blood-derived EPCs (hEPCs) and to assess the long-term efficacy of hEPCs in bone tissue engineering. METHODS: hEPCs were isolated from peripheral blood, cultured and characterized...
May 8, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28471698/design-approaches-to-myocardial-and-vascular-tissue-engineering
#6
Olukemi O Akintewe, Erin G Roberts, Nae-Gyune Rim, Michael A H Ferguson, Joyce Y Wong
Engineered tissues represent an increasingly promising therapeutic approach for correcting structural defects and promoting tissue regeneration in cardiovascular diseases. One of the challenges associated with this approach has been the necessity for the replacement tissue to promote sufficient vascularization to maintain functionality after implantation. This review highlights a number of promising prevascularization design approaches for introducing vasculature into engineered tissues. Although we focus on encouraging blood vessel formation within myocardial implants, we also discuss techniques developed for other tissues that could eventually become relevant to engineered cardiac tissues...
May 3, 2017: Annual Review of Biomedical Engineering
https://www.readbyqxmd.com/read/28471270/biomimetic-assembly-of-huvecs-and-muscle-cells-in-microgrooved-collagen-porous-scaffolds
#7
Shangwu Chen, Naoki Kawazoe, Guoping Chen
Porous scaffolds can be used to engineer 3D tissues for tissue repair. Coculture of vascular endothelial cells and the cells of target tissue in porous scaffolds is promising to engineer vascularized tissue. However, it is difficult to induce regeneration of anisotropic tissues such as muscle and nerve that have well aligned cells, blood vessels and extracellular matrix by using conventional porous scaffolds with homogeneous pore structures. In this study, we developed collagen porous scaffolds with parallel and concave microgrooves by using micropatterned ice template and freeze-drying...
May 4, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28470286/design-and-application-of-j-shaped-stress-strain-behavior-in-stretchable-electronics-a-review
#8
REVIEW
Yinji Ma, Xue Feng, John A Rogers, Yonggang Huang, Yihui Zhang
A variety of natural biological tissues (e.g., skin, ligaments, spider silk, blood vessel) exhibit 'J-shaped' stress-strain behavior, thereby combining soft, compliant mechanics and large levels of stretchability, with a natural 'strain-limiting' mechanism to prevent damage from excessive strain. Synthetic materials with similar stress-strain behaviors have potential utility in many promising applications, such as tissue engineering (to reproduce the nonlinear mechanical properties of real biological tissues) and biomedical devices (to enable natural, comfortable integration of stretchable electronics with biological tissues/organs)...
May 16, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28470226/flexible-and-highly-interconnected-multi-scale-patterned-chitosan-porous-membrane-produced-in-situ-from-mussel-shell-to-accelerate-wound-healing
#9
Xiaoping Song, Jie Mei, Xingying Zhang, Leyu Wang, Gurankit Singh, Malcolm M Q Xing, Xiaozhong Qiu
Utilization of the underlying mechanisms of biological systems is the principal endeavor of biomimetics, the primary goal of which is to treat on-going biological processes. From the perspective of tissue engineering, one purpose of biomimetics is to create highly cellular- or tissue-favored environments for bio-defect repair. Marine creatures such as mussels have inspired bioengineers to design ideal cellular substrates, strong adhesives, and other bioengineering materials. Herein, we report a novel mussel shell-derived membrane for wound dressing...
May 4, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28463576/advances-in-application-of-mechanical-stimuli-in-bioreactors-for-cartilage-tissue-engineering
#10
Ke Li, Chunqiu Zhang, Lulu Qiu, Lilan Gao, Xizheng Zhang
Articular cartilage (AC) is the weight-bearing tissue in diarthroses. It lacks the capacity for self-healing once there are injuries or diseases due to its avascularity. With the development of tissue engineering, repairing cartilage defects through transplantation of engineered cartilage that closely matches properties of native cartilage has become a new option for curing cartilage diseases. The main hurdle for clinical application of engineered cartilage is how to develop functional cartilage constructs for mass production in a credible way...
May 24, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28447994/scaling-of-engineered-vascular-grafts-using-3d-printed-guides-and-the-ring-stacking-method
#11
Cameron B Pinnock, Zhengfan Xu, Mai T Lam
Coronary artery disease remains a leading cause of death, affecting millions of Americans. With the lack of autologous vascular grafts available, engineered grafts offer great potential for patient treatment. However, engineered vascular grafts are generally not easily scalable, requiring manufacture of custom molds or polymer tubes in order to customize to different sizes, constituting a time-consuming and costly practice. Human arteries range in lumen diameter from about 2.0-38 mm and in wall thickness from about 0...
March 27, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28414752/an-angiogenesis-platform-using-a-cubic-artificial-eggshell-with-patterned-blood-vessels-on-chicken-chorioallantoic-membrane
#12
Wenjing Huang, Makoto Itayama, Fumihito Arai, Katsuko S Furukawa, Takashi Ushida, Tomohiro Kawahara
The chorioallantoic membrane (CAM) containing tiny blood vessels is an alternative to large animals for studies involving angiogenesis and tissue engineering. However, there is no technique to design the direction of growing blood vessels on the CAM at the microscale level for tissue engineering experiments. Here, a methodology is provided to direct blood vessel formation on the surface of a three-dimensional egg yolk using a cubic artificial eggshell with six functionalized membranes. A structure on the lateral side of the eggshell containing a straight channel and an interlinked chamber was designed, and the direction and formation area of blood vessels with blood flow was artfully defined by channels with widths of 70-2000 μm, without sharply reducing embryo viability...
2017: PloS One
https://www.readbyqxmd.com/read/28410495/local-induction-of-lymphangiogenesis-with-engineered-fibrin-binding-vegf-c-promotes-wound-healing-by-increasing-immune-cell-trafficking-and-matrix-remodeling
#13
Esra Güç, Priscilla S Briquez, Didier Foretay, Manuel A Fankhauser, Jeffrey A Hubbell, Witold W Kilarski, Melody A Swartz
Lymphangiogenesis occurs in inflammation and wound healing, yet its functional roles in these processes are not fully understood. Consequently, clinically relevant strategies for therapeutic lymphangiogenesis remain underdeveloped, particularly using growth factors. To achieve controlled, local capillary lymphangiogenesis with protein engineering and determine its effects on fluid clearance, leukocyte trafficking, and wound healing, we developed a fibrin-binding variant of vascular endothelial growth factor C (FB-VEGF-C) that is slowly released upon demand from infiltrating cells...
July 2017: Biomaterials
https://www.readbyqxmd.com/read/28397163/electrospun-silk-fibroin-gelatin-composite-tubular-matrices-as-scaffolds-for-small-diameter-blood-vessel-regeneration
#14
Chiara Marcolin, Lorenza Draghi, MariaCristina Tanzi, Silvia Faré
In this work an innovative method to obtain natural and biocompatible small diameter tubular structures is proposed. The biocompatibility and good mechanical properties of electrospun silk fibroin tubular matrices (SFts), extensively studied for tissue engineering applications, have been coupled with the excellent cell interaction properties of gelatin. In fact, an innovative non-cytotoxic gelatin gel, crosslinked in mild conditions via a Michael-type addition reaction, has been used to coat SFt matrices and obtain SFt/gel structures (I...
May 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28386578/large-field-of-view-optical-elastography-using-digital-image-correlation-for-biological-soft-tissue-investigation
#15
Daniel Claus, Marijo Mlikota, Jonathan Geibel, Thomas Reichenbach, Giancarlo Pedrini, Johannes Mischinger, Siegfried Schmauder, Wolfgang Osten
In minimally invasive surgery the haptic feedback, which represents an important tool for the localization of abnormalities, is no longer available. Elastography is an imaging technique that results in quantitative elastic parameters. It can hence be used to replace the lost sense of touch, as to enable tissue localization and discrimination. Digital image correlation is the chosen elastographic imaging technique. The implementation discussed here is clinically sound, based on a spectrally engineered illumination source that enables imaging of biological surface markers (blood vessels) with high contrast...
January 2017: Journal of Medical Imaging
https://www.readbyqxmd.com/read/28384617/the-study-of-angiogenesis-stimulated-by-multivalent-peptide-ligand-modified-alginate
#16
Bicui Wang, Wei Wang, Yanyan Yu, Yingxue Zhang, Jingwei Zhang, Zhi Yuan
Enhancing the affinity of scaffolds for endothelial cell (EC) is a crucial procedure for promoting angiogenesis in tissue engineering. In this work, to achieve stronger binding affinity with ECs, the peptide sequence REDV was conjugated onto gold nanoparticles (AuNPs) to construct a multivalent ligand (cREDV). Then, the EC adhesion and proliferation were studied to determine ligand affinity for ECs in vitro. The results show that the cREDV-modified alginate (cREDV-ALG) surface exhibited a selective adhesion to human umbilical vein endothelial cells (HUVECs) compared with NIH 3T3 cells...
June 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28383795/fabrication-and-characterization-of-electrospun-polycaprolactone-and-gelatin-composite-cuffs-for-tissue-engineered-blood-vessels
#17
Hannah A Strobel, Elizabeth L Calamari, Alexander Beliveau, Anjana Jain, Marsha W Rolle
Sewing cuffs incorporated within tissue-engineered blood vessels (TEBVs) enable graft anastomosis in vivo, and secure TEBVs to bioreactors in vitro. Alternative approaches to cuff design are required to achieve cuff integration with scaffold-free TEBVs during tissue maturation. To create porous materials that promote tissue integration, we used electrospinning to fabricate cuffs from polycaprolactone (PCL), PCL blended with gelatin, and PCL coated with gelatin, and evaluated cuff mechanical properties, porosity, and cellular attachment and infiltration...
April 6, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28382923/a-compliant-and-biomimetic-three-layered-vascular-graft-for-small-blood-vessels
#18
Yi Zhang, Xiangshun Li, Géraldine Guex, Shanshan Liu, Eike Müller, Riccardo Innocenti Malini, Huijing Zhao, Markus Rottmar, Katharina Maniura, Rene Rossi, Fabrizio Spano
Engineering a small diameter vascular graft with mechanical and biological properties comparable to living tissues remains challenging. Often, current devices lead to thrombosis and unsatisfactory long-term patency as a result of poor blood compatibility and a mismatch between the mechanical properties of the living tissue and the implanted biomaterial. Address-ing all these requirements is essential to produce scaffolds able to survive throughout the life of the patient. For this purpose, we fabricated a novel three-layered vascular graft by combining electrospinning and braiding...
April 6, 2017: Biofabrication
https://www.readbyqxmd.com/read/28382732/engineering-vascularized-flaps-using-adipose-derived-microvascular-ec-and-msc
#19
Alina Freiman, Yulia Shandalov, Dekel Rosenfeld, Erez Shor, Dror Ben-David, Shai Meretzki, Shulamit Levenberg, Dana Egozi
Human adipose-derived microvascular endothelial cells (HAMEC) and mesenchymal stem cells (MSC) have been shown to bear angiogenic and vasculogenic capabilities. We hypothesize that co-culturing HAMEC:MSC on a porous biodegradable scaffold in vitro, later implanted as a graft around femoral blood vessels in a rat, will result in its vascularization by host vessels, creating a functional vascular flap that can effectively treat a range of large full-thickness soft tissue defects. HAMEC were co-cultured with MSC on polymeric 3D porous constructs...
April 6, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28372287/organ-reconstruction-dream-or-reality-for%C3%A2-the%C3%A2-future
#20
J-F Stoltz, L Zhang, J S Ye, N De Isla
The relevance of research on reconstructed organs is justified by the lack of organs available for transplant and the growing needs for the ageing population. The development of a reconstructed organ involves two parallel complementary steps: de-cellularization of the organ with the need to maintain the structural integrity of the extracellular matrix and vascular network and re-cellularization of the scaffold with stem cells or resident cells.Whole organ engineering for liver, heart, lung or kidneys, is particularly difficult because of the structural complexity of organs and heterogeneity of cells...
2017: Bio-medical Materials and Engineering
keyword
keyword
68192
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"