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tissue engineered blood vessel

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https://www.readbyqxmd.com/read/29756539/skin-regeneration-with-a-scaffold-of-predefined-shape-and-bioactive-peptide-hydrogels
#1
Heejung Im, Su Hee Kim, Soo Hyun Kim, Youngmee Jung
We developed a highly elastic customized scaffold for soft-tissue regeneration and combined them with bioactive hydrogels with stem-cell-inducing ability. This was done to mimic mechanical properties of native soft tissues and improve the viability of transplanted cells as well as efficiency of tissue regeneration. The proposed study was aimed at evaluating various characteristics of scaffolds and investigating their tissue regenerating ability. Finger shaped porous scaffolds were successfully fabricated by an indirect 3D printing of poly (L-lactide-co-ε-caprolactone) (PLCL) which provides a high elasticity for soft tissue engineering...
May 14, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29756272/harnessing-human-decellularized-blood-vessel-matrices-and-cellular-construct-implants-to-promote-bone-healing-in-an-ex-vivo-organotypic-bone-defect-model
#2
Stefanie Inglis, Karl Heinrich Schneider, Janos M Kanczler, Heinz Redl, Richard O C Oreffo
Decellularized matrices offer a beneficial substitute for biomimetic scaffolds in tissue engineering. The current study examines the potential of decellularized placental vessel sleeves (PVS) as a periosteal protective sleeve to enhance bone regeneration in embryonic day 18 chick femurs contained within the PVS and cultured organotypically over a 10 day period. The femurs are inserted into decellularized biocompatibility-tested PVS and maintained in an organotypic culture for a period of 10 days. In femurs containing decellularized PVS, a significant increase in bone volume (p < 0...
May 14, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29749038/vascular-differentiation-from-pluripotent-stem-cells-in-3-d-auxetic-scaffolds
#3
Liqing Song, Mohammad Faisal Ahmed, Yan Li, Changchun Zeng, Yan Li
Auxetic scaffolds, i.e. scaffolds that can display negative Poisson's ratio, have unique physical properties and can expand transversally when axially strained or contract under compression. Auxetic materials have been used for bioprostheses and artery stents due to the enhanced compressive strength and shear stiffness. In vascular tissue engineering, auxetic scaffolds allow the widening of blood vessels when blood flows through (creating compressive stress) to prevent the blockage. However, the influence of auxetic materials on the cellular fate decision in local environment is unclear...
May 10, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29734152/cell-sheet-engineering-and-kidney-diseases
#4
Masatoshi Oka, Yoei Miyabe, Naoko Sugiura, Kosaku Nitta
Treatment using the cell sheet technology has been applied to various organs, including the cornea, heart, esophagus, periodontium, cartilage, middle ear, and lungs. It has been shown that the therapeutic efficacy of cell sheet transplantation involves 2 aspects, supplementation of cells and provision of cytokines to the affected organ. In addition, cell sheet transplantation also promotes repair of damage through the paracrine effects of cytokines derived from the transplanted cells. It is known that in cases of cell transplantation by injection, the transplanted cells are less likely to differentiate into renal tissue to supply cells, but repair is promoted by the actions of the transplanted cell-derived renotropic factors...
2018: Contributions to Nephrology
https://www.readbyqxmd.com/read/29732735/tissue-engineering-at-the-blood-contacting-surface-a-review-of-challenges-and-strategies-in-vascular-graft-development
#5
REVIEW
Daniel Radke, Wenkai Jia, Dhavan Sharma, Kemin Fena, Guifang Wang, Jeremy Goldman, Feng Zhao
Tissue engineered vascular grafts (TEVGs) are beginning to achieve clinical success and hold promise as a source of grafting material when donor grafts are unsuitable or unavailable. Significant technological advances have generated small-diameter TEVGs that are mechanically stable and promote functional remodeling by regenerating host cells. However, developing a biocompatible blood-contacting surface remains a major challenge. The TEVG luminal surface must avoid negative inflammatory responses and thrombogenesis immediately upon implantation and promote endothelialization...
May 7, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29724157/assembly-of-tissue-engineered-blood-vessels-with-spatially-controlled-heterogeneities
#6
Hannah A Strobel, Tracy Hookway, Marco Piola, Gianfranco Beniamino Fiore, Monica Soncini, Eben Alsberg, Marsha Rolle
Tissue-engineered human blood vessels may enable in vitro disease modeling and drug screening to accelerate advances in vascular medicine. Existing methods for tissue engineered blood vessel (TEBV) fabrication create homogenous tubes not conducive to modeling the focal pathologies characteristic of vascular disease. We developed a system for generating self-assembled human smooth muscle cell ring-units, which were fused together into TEBVs. The goal of this study was to assess the feasibility of modular assembly and fusion of ring building units to fabricate spatially-controlled, heterogeneous tissue tubes...
May 4, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29718653/silk-sponges-ornamented-with-placenta-derived-extracellular-matrix-augments-full-thickness-cutaneous-wound-healing-by-stimulating-neovascularization-and-cellular-migration
#7
Arun Prabhu Rameshbabu, Kamakshi Bankoti, Sayanti Datta, Elavarasan Subramani, Anupam Apoorva, Paulomi Ghosh, Priti Prasanna Maity, Padmavati Manchikanti, Koel Chaudhury, Santanu Dhara
Regeneration of full-thickness wound without scar formation is a multifaceted process which depends on in situ dynamic interactions between the tissue-engineered skin substitutes and newly formed reparative tissue. However, the majority of the tissue-engineered skin substitutes used so far in full-thickness wound healing cannot mimic the natural extracellular matrix (ECM) complexity and thus are incapable of providing a suitable niche for endogenous tissue repair. Herein, we demonstrated a simple approach to fabricate porous Hybrid Extracellular Matrix Sponges (HEMS) using Placental Extracellular Matrix (pECM) and Silk Fibroin (SF) for full-thickness wound healing...
May 2, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29717628/adipose-derived-stem-cell-implanted-poly-%C3%AF%C2%B5-caprolactone-chitosan-scaffold-improves-bladder-regeneration-in-a-rat-model
#8
Zhe Zhou, Hao Yan, Yidong Liu, Dongdong Xiao, Wei Li, Qiong Wang, Yang Zhao, Kang Sun, Ming Zhang, Mujun Lu
AIM: The study investigated the feasibility of seeding adipose-derived stem cells (ASCs) onto a poly(ϵ-caprolactone)/chitosan (PCL/CS) scaffold for bladder reconstruction using a rat model of bladder augmentation. MATERIALS & METHODS: In the experimental group, the autologous ASCs were seeded onto the PCL/CS scaffold for bladder augmentation. An unseeded scaffold was used for bladder augmentation as control group. The sham group was also set. RESULT: 8 weeks after implantation, more densely smooth muscles were detected in the experimental group with a larger bladder capacity and more intensive blood vessels...
April 2018: Regenerative Medicine
https://www.readbyqxmd.com/read/29710813/decellularized-diaphragmatic-muscle-drives-a-constructive-angiogenic-response-in-vivo
#9
Mario Enrique Alvarèz Fallas, Martina Piccoli, Chiara Franzin, Alberto Sgrò, Arben Dedja, Luca Urbani, Enrica Bertin, Caterina Trevisan, Piergiorgio Gamba, Alan J Burns, Paolo De Coppi, Michela Pozzobon
Skeletal muscle tissue engineering (TE) aims to efficiently repair large congenital and acquired defects. Biological acellular scaffolds are considered a good tool for TE, as decellularization allows structural preservation of tissue extracellular matrix (ECM) and conservation of its unique cytokine reservoir and the ability to support angiogenesis, cell viability, and proliferation. This represents a major advantage compared to synthetic scaffolds, which can acquire these features only after modification and show limited biocompatibility...
April 28, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29702010/pulp-regeneration-by-3-dimensional-dental-pulp-stem-cell-constructs
#10
Y Itoh, J I Sasaki, M Hashimoto, C Katata, M Hayashi, S Imazato
Dental pulp regeneration therapy for the pulpless tooth has attracted recent attention, and clinical trial studies are underway with the tissue engineering approach. However, there remain many concerns, including the extended period for regenerating the dental pulp. In addition, the use of scaffolds increases the risk of inflammation and infection. To establish a basic technology for novel dental pulp regenerative therapy that allows transplant of pulp-like tissue, we attempted to fabricate scaffold-free 3-dimensional (3D) cell constructs composed of dental pulp stem cells (DPSCs)...
April 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29689281/fabrication-of-engineered-tubular-tissue-for-small-blood-vessels-via-three-dimensional-cellular-assembly-and-organization-ex-vivo
#11
Taisuke Masuda, Mitsuhiro Ukiki, Yuka Yamagishi, Michiya Matsusaki, Mitsuru Akashi, Utako Yokoyama, Fumihito Arai
Although there is a great need for suitable vascular replacements in clinical practice, much progress needs to be made toward the development of a fully functional tissue-engineered construct. We propose a fabrication method of engineered tubular tissue for small blood vessels via a layer-by-layer cellular assembly technique using mouse smooth muscle cells, the construction of a poly-(L-lactide-co-ε-caprolactone) (PLCL) scaffold, and integration in a microfluidic perfusion culture system. The cylindrical PLCL scaffold is incised, expanded, and its surface is laminated with the cell layers...
April 21, 2018: Journal of Biotechnology
https://www.readbyqxmd.com/read/29679329/crimped-electrospun-fibers-for-tissue-engineering
#12
Pen-Hsiu Grace Chao
Collagen fibers exist in many parts of the body as parallel bundles with a wavy morphology, known as crimp. This crimp structure contributes to the nonlinear mechanical properties of the tissue, such as ligament, blood vessels, and intestine, which provide elasticity and prevent injury. To recapitulate the native collagen crimp structure, we report a robust method using electrospinning and post-processing to generate parallel polymeric fibers with crimp that simulate the structure-function relationship of native tissue mechanics...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29667149/three-dimensional-reconstructed-eccrine-sweat-glands-with-vascularization-and-cholinergic-and-adrenergic-innervation
#13
Mingjun Zhang, Haihong Li, Liyun Chen, Shuhua Fang, Sitian Xie, Changmin Lin
Functional integrity of the regenerated tissues requires not only structural integrity but also vascularization and innervation. We previously demonstrated that the three-dimensional (3D) reconstructed eccrine sweat glands had similar structures as those of the native ones did, but whether the 3D reconstructed glands possessing vascularization and innervation was still unknown. In the study, Matrigel-embedded eccrine sweat gland cells were implanted under the inguinal skin. Ten weeks post-implantation, the vascularization, and innervation in the 10-week reconstructed eccrine sweat glands and native human eccrine sweat glands were detected by immunofluorescence staining...
April 17, 2018: Journal of Molecular Histology
https://www.readbyqxmd.com/read/29627679/bone-tissue-engineering-strategy-based-on-the-synergistic-effects-of-silicon-and-strontium-ions
#14
Min Xing, Xiaoya Wang, Endian Wang, Long Gao, Jiang Chang
Multipotent human bone marrow mesenchymal stem cells (hBMSCs) are commonly used as seed cells in bone tissue engineering, but their clinical application is limited due to two challenges. One is the expansion of hBMSCs without loss of the stemness, and the other is the stimulation of osteogenic differentiation of hBMSCs when combined with biomaterials. In this study we demonstrated an approach by firstly elucidating the functional effects and optimal concentrations of Si and Sr ions on the proliferation and osteogenic differentiation of hBMSCs, and then designing bioactive bioceramic/alginate hydrogels which could release Si and Sr bioactive ions in the same optimal concentrations range for activation of the cells in vivo...
April 5, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29626696/fine-tuning-pro-angiogenic-effects-of-cobalt-for-simultaneous-enhancement-of-vascular-endothelial-growth-factor-secretion-and-implant-neovascularization
#15
Yoke Chin Chai, Luis Freitas Mendes, Nick van Gastel, Geert Carmeliet, Frank P Luyten
Rapid neovascularization of a tissue-engineered (TE) construct by the host vasculature is quintessential to warrant effective bone regeneration. This process can be promoted through active induction of angiogenic growth factor secretion or by implementation of in vitro pre-vascularization strategies. In this study, we aimed at optimizing the pro-angiogenic effect of Cobalt (Co2+ ) to enhance vascular endothelial growth factor (VEGF) expression by human periosteum-derived mesenchymal stem cells (hPDCs). Simultaneously we set out to promote microvascular network formation by co-culturing with human umbilical vein endothelial cells (HUVECs)...
April 4, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29617409/microvasculature-directed-thrombopoiesis-in-a-3d-in-vitro-marrow-microenvironment
#16
Surya Kotha, Sijie Sun, Amie Adams, Brian Hayes, Kiet T Phong, Ryan Nagao, Jo-Anna Reems, Dayong Gao, Beverly Torok-Storb, José A López, Ying Zheng
Vasculature is an interface between the circulation and the hematopoietic tissue providing the means for hundreds of billions of blood cells to enter the circulation every day in a regulated fashion. The precise mechanisms that control the interactions of hematopoietic cells with the vessel wall are largely undefined. Here, we report on the development of an in vitro 3D human marrow vascular microenvironment (VME) to study hematopoietic trafficking and the release of blood cells, specifically platelets. We show that mature megakaryocytes from aspirated marrow as well as megakaryocytes differentiated in culture from CD34+ cells can be embedded in a collagen matrix containing engineered microvessels to create a thrombopoietic VME...
2018: PloS One
https://www.readbyqxmd.com/read/29582235/characterization-of-isolated-liver-sinusoidal-endothelial-cells-for-liver-bioengineering
#17
A M Dingle, K K Yap, Y-W Gerrand, C J Taylor, E Keramidaris, Z Lokmic, A M Kong, H L Peters, W A Morrison, G M Mitchell
BACKGROUND: The liver sinusoidal capillaries play a pivotal role in liver regeneration, suggesting they may be beneficial in liver bioengineering. This study isolated mouse liver sinusoidal endothelial cells (LSECs) and determined their ability to form capillary networks in vitro and in vivo for liver tissue engineering purposes. METHODS AND RESULTS: In vitro LSECs were isolated from adult C57BL/6 mouse livers. Immunofluorescence labelling indicated they were LYVE-1+ /CD32b+ /FactorVIII+ /CD31- ...
March 26, 2018: Angiogenesis
https://www.readbyqxmd.com/read/29577604/neurotrophin-3-released-from-implant-of-tissue-engineered-fibroin-scaffolds-inhibits-inflammation-enhances-nerve-fiber-regeneration-and-improves-motor-function-in-canine-spinal-cord-injury
#18
Ge Li, Ming-Tian Che, Xiang Zeng, Xue-Cheng Qiu, Bo Feng, Bi-Qin Lai, Hui-Yong Shen, Eng-Ang Ling, Yuan-Shan Zeng
Spinal cord injury (SCI) normally results in cell death, scarring, cavitation, inhibitory molecules release, etc., which are regarded as a huge obstacle to reconnect the injured neuronal circuits due to the lack of effective stimulus. In this study, a functional gelatin sponge scaffold was used to inhibit local inflammation, enhance nerve fiber regeneration and improve neural conduction in the canine. This scaffold had good porosity and modified with neurotrophin-3 (NT-3)/fibroin complex, which showed sustained release in vitro...
March 25, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29555346/in-situ-organ-specific-vascularization-in-tissue-engineering
#19
REVIEW
Jiayin Fu, Dong-An Wang
Other than a few avascular tissues, almost all human tissues are connected to the systemic circulation via blood vessels that promote metabolism and function. Accordingly, engineered vascularization is a vital goal in tissue engineering for regenerative medicine. Endothelial cells (ECs) play a central role in vascularization with two significant specificities: physical interfaces between vascular stroma and blood, and phenotypic organ-specificity. Biomaterial scaffolding technologies that address these unique properties of ECs have been developed to promote the vascularization of various engineered tissues, and these have advanced from mimicking vascular architectures ex situ towards promoting spontaneous angiogenic remodeling in situ...
March 16, 2018: Trends in Biotechnology
https://www.readbyqxmd.com/read/29549334/evaluation-of-a-miniaturized-biologically-vascularized-scaffold-in-vitro-and-in-vivo
#20
Sebastian Kress, Johannes Baur, Christoph Otto, Natalie Burkard, Joris Braspenning, Heike Walles, Joachim Nickel, Marco Metzger
In tissue engineering, the generation and functional maintenance of dense voluminous tissues is mainly restricted due to insufficient nutrient supply. Larger three-dimensional constructs, which exceed the nutrient diffusion limit become necrotic and/or apoptotic in long-term culture if not provided with an appropriate vascularization. Here, we established protocols for the generation of a pre-vascularized biological scaffold with intact arterio-venous capillary loops from rat intestine, which is decellularized under preservation of the feeding and draining vascular tree...
March 16, 2018: Scientific Reports
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