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cardiovascular tissue engineering

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https://www.readbyqxmd.com/read/29135295/-re-engineering-of-glucose-exposure-in-peritoneal-dialysis
#1
Emília Mácsai, István Kiss
The significance of peritoneal dialysis in kidney replacement therapy is expected to increase, so it is important to reconsider glucose exposure to minimize the adverse effects. The first step was to develop biocompatible modern PD solutions to reduce the local and systemic adverse effects of current conventional glucose-based ones. According to the limited clinical experience, there are no clear data on better clinical outcome. Besides this there is a suspected theoretical correlation between development of encapsulating peritoneal sclerosis and chronic local irritation of peritoneal surface by glucose...
October 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29057501/different-approaches-to-heart-valve-decellularization-a-comprehensive-overview-of-the-past-30%C3%A2-years
#2
REVIEW
Filippo Naso, Alessandro Gandaglia
Xenogeneic decellularized heart valve scaffolds have the potential to overcome the limitations of existing bioprosthetic heart valves that have limited duration due to calcification and tissue degeneration phenomena. This article presents a review of 30 years of decellularization approaches adopted in cardiovascular tissue engineering, with a focus on the use, either individually or in combination, of different detergents. The safety and efficacy of cell-removal procedures are specifically reported and discussed, as well as the structure and biomechanics of the treated extracellular matrix (ECM)...
October 22, 2017: Xenotransplantation
https://www.readbyqxmd.com/read/29054608/a-sweet-spot-for-fluid-induced-oscillations-in-the-conditioning-of-stem-cell-based-engineered-heart-valve-tissues
#3
Alexander Williams, Sana Nasim, Manuel Salinas, Arash Moshkforoush, Nikolaos Tsoukias, Sharan Ramaswamy
Fluid-induced shear stresses are involved in the development of cardiovascular tissues. In a tissue engineering framework, this stimulus has also been considered as a mechanical regulator of stem cell differentiation. We recently demonstrated that the fluid-oscillating effect in combination with a physiologically-relevant shear stress magnitude contributes to the formation of stem cell-derived de novo heart valve tissues. However, the range of oscillations necessary to induce favorable gene expression and engineered tissue formation is unknown...
October 7, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29054134/thymus-derived-mesenchymal-stem-cells-for-tissue-engineering-clinical-grade-cardiovascular-grafts
#4
Dominga Iacobazzi, Megan Swim, Ambra Albertario, Massimo Caputo, Mohamed T Ghorbel
Mesenchymal stem cells (MSCs) are attractive tools for regenerative medicine because of their multi-differentiation potential and immunomodulation capacity. In congenital heart defect surgical correction, replacement grafts lacking growth potential are commonly used. Tissue engineering promises to overcome the limitations of these grafts. In this study, we hypothesized that human thymus derived MSCs are a suitable tool to tissue engineer a living vascular graft with good integration and patency once implanted in vivo...
October 20, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29053443/enhancement-of-intercellular-electrical-synchronization-by-conductive-materials-in-cardiac-tissue-engineering
#5
Yu Wu, Liang Guo
OBJECTIVE: cardiac tissue regeneration for the treatment of cardiovascular diseases has been of great research interest. Under the hypothesis that electrical synchronization of cardiac cells can be aided by conductive materials, electrically conductive scaffolds have been frequently used to improve cardiac tissue regeneration. However, theoretical analysis is presently absent in examining the underlying mechanism and rationally guiding the design of these conductive scaffolds. METHODS: here, equivalent-circuit models are proposed, in which two adjacent groups of cardiomyocytes are grown either on a bulk conductive substrate or around conductive nanostructures...
October 15, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28994390/clearance-of-beta-amyloid-is-facilitated-by-apolipoprotein-e-and-circulating-high-density-lipoproteins-in-bioengineered-human-vessels
#6
Jerome Robert, Emily B Button, Brian Yuen, Megan Gilmour, Kevin Kang, Arvin Bahrabadi, Sophie Stukas, Wenchen Zhao, Iva Kulic, Cheryl L Wellington
Amyloid plaques, consisting of deposited beta-amyloid (Aβ), are a neuropathological hallmark of Alzheimer's Disease (AD). Cerebral vessels play a major role in AD, as Aβ is cleared from the brain by pathways involving the cerebrovasculature, most AD patients have cerebrovascular amyloid (cerebral amyloid angiopathy (CAA), and cardiovascular risk factors increase dementia risk. Here we present a notable advance in vascular tissue engineering by generating the first functional 3-dimensioinal model of CAA in bioengineered human vessels...
October 10, 2017: ELife
https://www.readbyqxmd.com/read/28988692/the-survey-on-cellular-and-tissue-engineered-therapies-in-europe-and-neighboring-eurasian-countries-in-2014-and-2015
#7
Hilary Ireland, Max H P Gay, Helen Baldomero, Barbara De Angelis, Hossein Baharvand, Mark W Lowdell, Jakob Passweg, Ivan Martin
BACKGROUND AIMS: With the support of five established scientific organizations, this report, the seventh of its kind, describes activity in Europe for the years 2014 and 2015 in the area of cellular and tissue-engineered therapies, excluding hematopoietic stem cell (HSC) treatments for the reconstitution of hematopoiesis. METHODS: In 2015 [respectively 2014], 205 [276] teams from 32 countries responded to the cellular and tissue-engineered therapy survey; 178 [126] teams reported treating 3686 [2665] patients...
October 4, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28978275/low-immunogenic-endothelial-cells-maintain-morphofunctional-properties-needed-for-tissue-engineering
#8
Skadi Lau, Dorothee Eicke, Marco Carvalho Oliveira, Bettina Wiegmann, Claudia Schrimpf, Axel Haverich, Rainer Blasczyk, Mathias Wilhelmi, Constanςa Figueiredo, Ulrike Böer
The limited availability of native vessels suitable for the application as hemodialysis shunts or bypass material demands new strategies in cardiovascular surgery. Tissue engineered vascular grafts containing autologous cells are considered as ideal vessel replacements due to the low risk of rejection. However, endothelial cells (EC), which are central components of natural blood vessels, are difficult to obtain from elderly patients of poor health. Umbilical cord blood represents a promising alternative source for EC but their allogeneic origin corresponds with the risk of rejection after allotransplantation...
October 5, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28952550/3d-bioprinting-and-in-vitro-cardiovascular-tissue-modeling
#9
REVIEW
Jinah Jang
Numerous microfabrication approaches have been developed to recapitulate morphologically and functionally organized tissue microarchitectures in vitro; however, the technical and operational limitations remain to be overcome. 3D printing technology facilitates the building of a construct containing biomaterials and cells in desired organizations and shapes that have physiologically relevant geometry, complexity, and micro-environmental cues. The selection of biomaterials for 3D printing is considered one of the most critical factors to achieve tissue function...
August 18, 2017: Bioengineering
https://www.readbyqxmd.com/read/28945009/biomechanical-regulation-of-mesenchymal-stem-cells-for-cardiovascular-tissue-engineering
#10
REVIEW
Kayla Henderson, Andrew D Sligar, Victoria P Le, Jason Lee, Aaron B Baker
Mesenchymal stem cells (MSCs) are an appealing potential therapy for vascular diseases; however, many challenges remain in their clinical translation. While the use of biochemical, pharmacological, and substrate-mediated treatments to condition MSCs has been subjected to intense investigation, there has been far less exploration of using these treatments in combination with applied mechanical force for conditioning MSCs toward vascular phenotypes. This review summarizes the current understanding of the use of applied mechanical forces to differentiate MSCs into vascular cells and enhance their therapeutic potential for cardiovascular disease...
September 25, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28914400/an-in-vivo-study-on-endothelialized-vascular-grafts-produced-by-autologous-biotubes-and-adipose-stem-cells-adscs
#11
Yu Chieh Tseng, Jun Neng Roan, Ying Chiang Ho, Chih Chan Lin, Ming Long Yeh
Currently, commercial synthetic vascular grafts made from Dacron and ePTFE for small-diameter, vascular applications (<6 mm) show limited reendothelization and are less compliant, often resulting in thrombosis and intimal hyperplasia. Although good blood compatibility can be achieved in autologous arteries and veins, the number of high quality harvest sites is limited, and the grafts are size-mismatched for use in the fistula or cardiovascular bypass surgery; thus, alternative small graft substitutes must be developed...
September 15, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28911663/recent-advances-in-oral-delivery-of-drugs-and-bioactive-natural-products-using-solid-lipid-nanoparticles-as-the-carriers
#12
REVIEW
Chih-Hung Lin, Chun-Han Chen, Zih-Chan Lin, Jia-You Fang
Chemical and enzymatic barriers in the gastrointestinal (GI) tract hamper the oral delivery of many labile drugs. The GI epithelium also contributes to poor permeability for numerous drugs. Drugs with poor aqueous solubility have difficulty dissolving in the GI tract, resulting in low bioavailability. Nanomedicine provides an opportunity to improve the delivery efficiency of orally administered drugs. Solid lipid nanoparticles (SLNs) are categorized as a new generation of lipid nanoparticles consisting of a complete solid lipid matrix...
April 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28892929/connective-tissue-growth-factor-transgenic-mouse-develops-cardiac-hypertrophy-lean-body-mass-and-alopecia
#13
Edem Nuglozeh
INTRODUCTION: Connective Tissue Growth Factor (CTGF/CCN2) is one of the six members of cysteine-rich, heparin-binding proteins, secreted as modular protein and recognised to play a major function in cell processes such as adhesion, migration, proliferation and differentiation as well as chondrogenesis, skeletogenesis, angiogenesis and wound healing. The capacity of CTGF to interact with different growth factors lends an important role during early and late development, especially in the anterior region of the embryo...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28879656/variability-in-responses-observed-in-human-white-adipose-tissue-models
#14
Rosalyn D Abbott, Francis E Borowsky, Carlo A Alonzo, Adam Zieba, Irene Georgakoudi, David L Kaplan
Obesity is a risk factor for a myriad of diseases including diabetes, cardiovascular dysfunction, cirrhosis and cancer and there is a need for new systems to study how excess adipose tissue relates to the onset of disease processes. This study provides proof of concept patient-specific tissue models of human white adipose tissue to accommodate the variability in human samples. Our 3D tissue engineering approach established lipolytic responses and changes in insulin-stimulated glucose uptake from small volumes of human lipoaspirate, making this methodology useful for patient specific sample source assessments of treatment strategies, drug responses, disease mechanisms and other responses that vary between patients...
September 6, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28875152/artificial-cardiac-muscle-with-or-without-the-use-of-scaffolds
#15
REVIEW
Yifei Li, Donghui Zhang
During the past several decades, major advances and improvements now promote better treatment options for cardiovascular diseases. However, these diseases still remain the single leading cause of death worldwide. The rapid development of cardiac tissue engineering has provided the opportunity to potentially restore the contractile function and retain the pumping feature of injured hearts. This conception of cardiac tissue engineering can enable researchers to produce autologous and functional biomaterials which represents a promising technique to benefit patients with cardiovascular diseases...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28854493/triton-x-100-combines-with-chymotrypsin-a%C3%A2-more-promising-protocol-to-prepare-decellularized-porcine-carotid-arteries
#16
Fei Wang, Jian Zhang, Rong Wang, Yongquan Gu, Jianxin Li, Cong Wang
BACKGROUND: Morbidity and mortality of cardiovascular diseases are increasing in recent years. To solve these problems, vascular transplantation has become a common approach. Decellularization has been a hot spot of tissue engineering to prepare vessel substitutes for vascular transplantation. However, there is no established canonical protocol for decellularization thus far. OBJECTIVE: To further understand the decellularization effect of decellularization protocols and the causal relationship between decellularization and mechanical properties...
2017: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/28832034/surface-modified-polymers-for-cardiac-tissue-engineering
#17
REVIEW
Ambigapathi Moorthi, Yu-Chang Tyan, Tze-Wen Chung
Cardiovascular disease (CVD), leading to myocardial infarction and heart failure, is one of the major causes of death worldwide. The physiological system cannot significantly regenerate the capabilities of a damaged heart. The current treatment involves pharmacological and surgical interventions; however, less invasive and more cost-effective approaches are sought. Such new approaches are developed to induce tissue regeneration following injury. Hence, regenerative medicine plays a key role in treating CVD...
September 26, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28826352/pcl-pdms-pcl-copolymer-based-microspheres-mediate-cardiovascular-differentiation-from-embryonic-stem-cells
#18
Liqing Song, Mohammad Faisel Ahmed, Yan Li, Julie Bejoy, Changchun Zeng, Yan Li
Poly-ɛ-caprolactone (PCL) based microspheres have received much attention as drug or growth factor delivery carriers and tissue engineering scaffolds due to their biocompatibility, biodegradability, and tunable biophysical properties. In addition, PCL and polydimethylsiloxane (PDMS) can be fabricated into thermoresponsive shape memory polymers for various biomedical applications (e.g., smart sutures and vascular stents). However, the influence of biophysical properties of PCL-PDMS based microspheres on stem cell lineage commitment has not been well understood...
September 28, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28811655/a-tissue-engineered-blood-vessel-model-of-hutchinson-gilford-progeria-syndrome-using-human-ipsc-derived-smooth-muscle-cells
#19
Leigh Atchison, Haoyue Zhang, Kan Cao, George A Truskey
Hutchison-Gilford Progeria Syndrome (HGPS) is a rare, accelerated aging disorder caused by nuclear accumulation of progerin, an altered form of the Lamin A gene. The primary cause of death is cardiovascular disease at about 14 years. Loss and dysfunction of smooth muscle cells (SMCs) in the vasculature may cause defects associated with HGPS. Due to limitations of 2D cell culture and mouse models, there is a need to develop improved models to discover novel therapeutics. To address this need, we produced a functional three-dimensional model of HGPS that replicates an arteriole-scale tissue engineered blood vessel (TEBV) using induced pluripotent stem cell (iPSC)-derived SMCs from an HGPS patient...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28805830/in-vitro-and-in-vivo-analysis-of-visible-light-crosslinkable-gelatin-methacryloyl-gelma-hydrogels
#20
Iman Noshadi, Seonki Hong, Kelly E Sullivan, Ehsan Shirzaei Sani, Roberto Portillo-Lara, Ali Tamayol, Su Ryon Shin, Albert E Gao, Whitney L Stoppel, Lauren D Black Iii, Ali Khademhosseini, Nasim Annabi
Photocrosslinkable materials have been frequently used for constructing soft and biomimetic hydrogels for tissue engineering. Although ultraviolet (UV) light is commonly used for photocrosslinking such materials, its use has been associated with several biosafety concerns such as DNA damage, accelerated aging of tissues, and cancer. Here we report an injectable visible light crosslinked gelatin-based hydrogel for myocardium regeneration. Mechanical characterization revealed that the compressive moduli of the engineered hydrogels could be tuned in the range of 5-56 kPa by changing the concentrations of the initiator, co-initiator and co-monomer in the precursor formulation...
September 26, 2017: Biomaterials Science
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