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cardiovascular tissue engineering

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https://www.readbyqxmd.com/read/28071663/covalent-modification-of-pericardial-patches-for-sustained-rapamycin-delivery-inhibits-venous-neointimal-hyperplasia
#1
Hualong Bai, Jung Seok Lee, Elizabeth Chen, Mo Wang, Ying Xing, Tarek M Fahmy, Alan Dardik
Prosthetic grafts and patches are commonly used in cardiovascular surgery, however neointimal hyperplasia remains a significant concern, especially under low flow conditions. We hypothesized that delivery of rapamycin from nanoparticles (NP) covalently attached to patches allows sustained site-specific delivery of therapeutic agents targeted to inhibit localized neointimal hyperplasia. NP were covalently linked to pericardial patches using EDC/NHS chemistry and could deliver at least 360 ng rapamycin per patch without detectable rapamycin in serum; nanoparticles were detectable in the liver, kidney and spleen but no other sites within 24 hours...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28060283/preparation-of-raav9-to-overexpress-or-knockdown-genes-in-mouse-hearts
#2
Jian Ding, Zhi-Qiang Lin, Jian-Ming Jiang, Christine E Seidman, Jonathan G Seidman, William T Pu, Da-Zhi Wang
Controlling the expression or activity of specific genes through the myocardial delivery of genetic materials in murine models permits the investigation of gene functions. Their therapeutic potential in the heart can also be determined. There are limited approaches for in vivo molecular intervention in the mouse heart. Recombinant adeno-associated virus (rAAV)-based genome engineering has been utilized as an essential tool for in vivo cardiac gene manipulation. The specific advantages of this technology include high efficiency, high specificity, low genomic integration rate, minimal immunogenicity, and minimal pathogenicity...
December 17, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28057791/from-microscale-devices-to-3d-printing-advances-in-fabrication-of-3d-cardiovascular-tissues
#3
REVIEW
Anton V Borovjagin, Brenda M Ogle, Joel L Berry, Jianyi Zhang
Current strategies for engineering cardiovascular cells and tissues have yielded a variety of sophisticated tools for studying disease mechanisms, for development of drug therapies, and for fabrication of tissue equivalents that may have application in future clinical use. These efforts are motivated by the need to extend traditional 2-dimensional (2D) cell culture systems into 3D to more accurately replicate in vivo cell and tissue function of cardiovascular structures. Developments in microscale devices and bioprinted 3D tissues are beginning to supplant traditional 2D cell cultures and preclinical animal studies that have historically been the standard for drug and tissue development...
January 6, 2017: Circulation Research
https://www.readbyqxmd.com/read/28042926/the-potential-impact-of-gut-microbiota-on-your-health-current-status-and-future-challenges
#4
Stitaya Sirisinha
Our health and probably also our behaviors and mood depend not only on what we eat or what we do (lifestyle behaviors), but also on what we host. It is well established for decades that all vertebrates including humans are colonized by a wide array of bacteria, fungi, eukaryotic parasites and viruses, and that, at steady state (homeostasis), this community of microbes establishes a friendly mutual relationship with the host. The term microbiota was originally meant to represent an ecological community of commensals and potentially pathogenic microbes that live within our bodies, but it is now used interchangeably with the term microbiome which was initially meant to represent a collective genome of the microbiota...
December 2016: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/27995570/hydrodynamic-assessment-of-aortic-valves-prepared-from-porcine-small-intestinal-submucosa
#5
Sharan Ramaswamy, Makensley Lordeus, Omkar V Mankame, Lilliam Valdes-Cruz, Steven Bibevski, Sarah M Bell, Ivan Baez, Frank Scholl
Infants and children born with severe cardiac valve lesions have no effective long term treatment options since currently available tissue or mechanical prosthetic valves have sizing limitations and no avenue to accommodate the growth of the pediatric patient. Tissue engineered heart valves (TEHVs) which could provide for growth, self-repair, infection resistance, and long-term replacement could be an ideal solution. Porcine small intestinal submucosa (PSIS) has recently emerged as a potentially attractive bioscaffold for TEHVs...
December 19, 2016: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/27981886/additive-manufacturing-of-vascular-grafts-and-vascularized-tissue-constructs
#6
Laura Elomaa, Yunzhi Peter Yang
There is a great need for engineered vascular grafts among patients with cardiovascular diseases who are in need of bypass therapy and lack autologous healthy blood vessels. In addition, because of the severe worldwide shortage of organ donors, there is an increasing need for engineered vascularized tissue constructs as an alternative to organ transplants. Additive manufacturing (AM) offers great advantages and flexibility of fabrication of cell-laden, multimaterial, and anatomically shaped vascular grafts and vascularized tissue constructs...
January 10, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/27942617/surface-modification-and-endothelialization-of-polyurethane-for-vascular-tissue-engineering-applications-a-review
#7
REVIEW
Iman Adipurnama, Ming-Chien Yang, Tomasz Ciach, Beata Butruk-Raszeja
Cardiovascular implants, especially vascular grafts made of synthetic polymers, find wide clinical applications in the treatment of cardiovascular diseases. However, cases of failure still exist, notably caused by restenosis and thrombus formation. Aiming to solve these problems, various approaches to surface modification of synthetic vascular grafts have been used to improve both the hemocompatibility and long-term patency of artificial vascular grafts. Surface modification using hydrophilic molecules can enhance hemocompatibility, but this may limit the initial vascular endothelial cell adhesion...
December 20, 2016: Biomaterials Science
https://www.readbyqxmd.com/read/27941901/a-novel-bioreactor-system-for-the-assessment-of-endothelialization-on-deformable-surfaces
#8
Björn J Bachmann, Laura Bernardi, Christian Loosli, Julian Marschewski, Michela Perrini, Martin Ehrbar, Paolo Ermanni, Dimos Poulikakos, Aldo Ferrari, Edoardo Mazza
The generation of a living protective layer at the luminal surface of cardiovascular devices, composed of an autologous functional endothelium, represents the ideal solution to life-threatening, implant-related complications in cardiovascular patients. The initial evaluation of engineering strategies fostering endothelial cell adhesion and proliferation as well as the long-term tissue homeostasis requires in vitro testing in environmental model systems able to recapitulate the hemodynamic conditions experienced at the blood-to-device interface of implants as well as the substrate deformation...
December 12, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27916652/exploring-pericyte-and-cardiac-stem-cell-secretome-unveils-new-tactics-for-drug-discovery
#9
REVIEW
Georgina M Ellison-Hughes, Paolo Madeddu
Ischaemic diseases remain a major cause of morbidity and mortality despite continuous advancements in medical and interventional treatments. Moreover, available drugs reduce symptoms associated with tissue ischaemia, without providing a definitive repair. Cardiovascular regenerative medicine is an expanding field of research that aims to improve the treatment of ischaemic disorders through restorative methods, such as gene therapy, stem cell therapy, and tissue engineering. Stem cell transplantation has salutary effects through direct and indirect actions, the latter being attributable to growth factors and cytokines released by stem cells and influencing the endogenous mechanisms of repair...
December 2, 2016: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27884781/epigenetic-mechanisms-underlying-lifespan-and-age-related-effects-of-dietary-restriction-and-the-ketogenic-diet
#10
Cesar L Moreno, Charles V Mobbs
Aging constitutes the central risk factor for major diseases including many forms of cancer, neurodegeneration, and cardiovascular diseases. The aging process is characterized by both global and tissue-specific changes in gene expression across taxonomically diverse species. While aging has historically been thought to entail cell-autonomous, even stochastic changes, recent evidence suggests that modulation of this process can be hierarchal, wherein manipulations of nutrient-sensing neurons (e.g., in the hypothalamus) produce peripheral effects that may modulate the aging process itself...
November 22, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27871114/bone-marrow-stromal-stem-cells-in-tissue-engineering-and-regenerative-medicine
#11
A Polymeri, W V Giannobile, D Kaigler
Bone marrow stromal stem cells (BMSCs) are adult multipotent cells, which have the potential to differentiate into cell types of mesodermal origin, namely osteocytes, adipocytes, and chondrocytes. Due to their accessibility and expansion potential, BMSCs have historically held therapeutic promise in tissue engineering and regenerative medicine applications. More recently, it has been demonstrated that not only can bone marrow stromal stem cells directly participate in tissue regeneration, but they also have the capacity to migrate to distant sites of tissue injury, where they can participate in tissue repair either directly through their differentiation or indirectly through paracrine mechanisms...
November 2016: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/27866022/novel-approaches-toward-the-generation-of-bioscaffolds-as-a-potential-therapy-in-cardiovascular-tissue-engineering
#12
REVIEW
Fahimeh Shahabipour, Maciej Banach, Thomas P Johnston, Matteo Pirro, Amirhossein Sahebkar
Cardiovascular disease associated with myocardial infarction (MI) is among the leading causes of mortality worldwide, in part, due to the limited regenerative capacity of tissues. Although various approaches have been employed to generate bioartificial myocardial tissues, including surgical reconstruction and the use of biosynthetic or biological cell-free grafts, many challenges still remain. Natural biomaterials based on decellularization have made significant inroads into the development of favorable biomatrices for myocardial tissue regeneration...
February 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27854552/regulation-of-sequential-release-of-growth-factors-using-bilayer-polymeric-nanoparticles-for-cardiac-tissue-engineering
#13
Mohammad Izadifar, Michael E Kelly, Xiongbiao Chen
AIM: Cardiac tissue engineering aims to develop engineered constructs for myocardial infarction repair, where a challenge is the control of growth factor (GF) sequential release. Herein, bilayer polymeric nanoparticles composed of a GF-encapsulating core surrounded by rate-regulating shell were developed for sequential GF release. MATERIALS & METHODS: Single and bilayer polymeric nanoparticles were fabricated, characterized and biologically assessed. A novel 'Geno-Neural model' was developed and validated for rate-programming of the nanoparticles...
November 17, 2016: Nanomedicine
https://www.readbyqxmd.com/read/27845938/elastin-like-recombinamers-multilayered-nanofibrous-scaffolds-for-cardiovascular-applications
#14
M Putzu, F Causa, V Nele, I González de Torre, J C Rodriguez-Cabello, P A Netti
Coronary angioplasty is the most widely used technique for removing atherosclerotic plaques in blood vessels. The regeneration of the damaged intima layer after this treatment is still one of the major challenges in the field of cardiovascular tissue engineering. Different polymers have been used in scaffold manufacturing in order to improve tissue regeneration. Elastin-mimetic polymers are a new class of molecules that have been synthesized and used to obtain small diameter fibers with specific morphological characteristics...
November 15, 2016: Biofabrication
https://www.readbyqxmd.com/read/27834758/current-status-of-tissue-engineering-heart-valve
#15
Toshiharu Shinoka, Hideki Miyachi
The development of surgically implantable heart valve prostheses has contributed to improved outcomes in patients with cardiovascular disease. However, there are drawbacks, such as risk of infection and lack of growth potential. Tissue-engineered heart valve (TEHV) holds great promise to address these drawbacks as the ideal TEHV is easily implanted, biocompatible, non-thrombogenic, durable, degradable, and ultimately remodels into native-like tissue. In general, three main components used in creating a tissue-engineered construct are (1) a scaffold material, (2) a cell type for seeding the scaffold, and (3) a subsequent remodeling process driven by cell accumulation and proliferation, and/or biochemical and mechanical signaling...
November 2016: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/27834123/translational-applications-of-tissue-engineering-in-cardiovascular-medicine
#16
Y Murat Elçin, Arin Dogan, Eser Elçin
Cardiovascular diseases are the leading cause of worldwide deaths. Current paradigm in medicine seeks novel approaches for the treatment of progressive or end-stage diseases. The organ transplantation option is limited in availability and unfortunately, a great number of patients are lost while waiting for donor organs. Animal studies have shown that upon myocardial infarction, it may be possible to stop adverse remodeling in its tracks and reverse with tissue engineering methods. Regaining the myocardium function and avoiding further deterioration towards heart failure can benefit millions of people with a significantly lesser burden on healthcare systems worldwide...
November 11, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27814290/influence-of-nanoporous-poly-ether-imide-particle-extracts-on-human-aortic-endothelial-cells-haecs
#17
Reddi K Kumar, Sayantani Basu, Horst-Dieter Lemke, Joachim Jankowski, Karl Kratz, Andreas Lendlein, Sarada D Tetali
Accumulated uremic toxins like indoxyl sulphate, hippuric acid and p-cresyl sulphates in renal failure patients stimulate proinflammatory effects, and consequently kidney and cardiovascular diseases. Low clearance rate of these uremic toxins from the blood of uremic patients by convention techniques like hemodialysis is due to their strong covalent albumin binding (greater than 95%) and hydrophobic nature, which led to alternatives like usage of hydrophobic adsorber's in removing these toxins from the plasma of kidney patients...
November 4, 2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27780764/biodegradable-and-biomimetic-elastomeric-scaffolds-for-tissue-engineered-heart-valves
#18
REVIEW
Yingfei Xue, Vinayak Sant, Julie Phillippi, Shilpa Sant
: Valvular heart diseases are the third leading cause of cardiovascular disease, resulting in more than 25,000 deaths annually in the United States. Heart valve tissue engineering (HVTE) has emerged as a putative treatment strategy such that the designed construct would ideally withstand native dynamic mechanical environment, guide regeneration of the diseased tissue and more importantly, have the ability to grow with the patient. These desired functions could be achieved by biomimetic design of tissue-engineered constructs that recapitulate in vivo heart valve microenvironment with biomimetic architecture, optimal mechanical properties and possess suitable biodegradability and biocompatibility...
October 22, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27778466/a-double-chamber-rotating-bioreactor-for-enhanced-tubular-tissue-generation-from-human-mesenchymal-stem-cells
#19
I Stefani, M A Asnaghi, J J Cooper-White, S Mantero
Cardiovascular diseases represent a major global health burden, with high rates of mortality and morbidity. Autologous grafts are commonly used to replace damaged or failing blood vessels, however such approaches are hampered by the scarcity of suitable graft tissue, donor site morbidity and poor long-term stability. Tissue engineering has been investigated as a means by which exogenous vessel grafts can be produced, with varying levels of success to date, a result of mismatched mechanical properties of these vessel substitutes and inadequate ex vivo vessel tissue genesis...
October 24, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27778297/intrinsic-cell-stress-is-independent-of-organization-in-engineered-cell-sheets
#20
Inge A E W van Loosdregt, Sylvia Dekker, Patrick W Alford, Cees W J Oomens, Sandra Loerakker, Carlijn V C Bouten
Understanding cell contractility is of fundamental importance for cardiovascular tissue engineering, due to its major impact on the tissue's mechanical properties as well as the development of permanent dimensional changes, e.g., by contraction or dilatation of the tissue. Previous attempts to quantify contractile cellular stresses mostly used strongly aligned monolayers of cells, which might not represent the actual organization in engineered cardiovascular tissues such as heart valves. In the present study, therefore, we investigated whether differences in organization affect the magnitude of intrinsic stress generated by individual myofibroblasts, a frequently used cell source for in vitro engineered heart valves...
October 24, 2016: Cardiovascular Engineering and Technology
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