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https://www.readbyqxmd.com/read/29316579/-management-of-compensated-liver-cirrhosis-2018-evidence-based-prophylactic-measures
#1
Kathrin Karkmann, Felix Piecha, Anna Caterina Rünzi, Lisa Schulz, Moritz von Wulffen, Daniel Benten, Johannes Kluwe, Henning Wege
In 2015, more than 13 000 people died due to the consequences of liver cirrhosis in Germany. Frequently, relevant liver fibrosis is diagnosed by non-invasive methods (e. g., ultrasound-based measurement of liver stiffness) already in the compensated stage. Following diagnosis of liver fibrosis, a thorough investigation of the underlying chronic liver disease and effective treatment are important to prevent progression to decompensated cirrhosis. Since morbidity and mortality dramatically increase in the decompensated stage (patients may present with jaundice, ascites, hepatic encephalopathy, gastrointestinal bleeding) with an upsurge in 1-year-mortality from 1 - 3...
January 2018: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/29295696/antibody-based-epcam-targeted-therapy-of-cancer-review-and-update
#2
Shirin Eyvazi, Safar Farajnia, Siavoush Dastmalchi, Farzad Kanipour, Habib Zarredar, Mojgan Bandehpour
Todays, after four decades of the discovery of monoclonal antibodies by Kohler and Milstein in 1975, a dozen of antibodies are used in cancer targeted therapy with different strategies. The success of these antibodies depends on the specificity of antigens expressed on the cancer cells. Epithelial cell adhesion molecule (EpCAM), a homophilic cell-cell adhesion glycoprotein is a well- known tumor antigen, which expresses on epithelial tumors and circulating tumor cells as well as cancer stem cells. The EpCAM signaling pathway is associated with proliferation, differentiation and adhesion of epithelial cancer cells...
January 1, 2018: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29290785/albumin-to-alkaline-phosphatase-ratio-as-an-independent-prognostic-factor-for-overall-survival-of-advanced-hepatocellular-carcinoma-patients-without-receiving-standard-anti-cancer-therapies
#3
Xiurong Cai, Zhanhong Chen, Jie Chen, Xiaokun Ma, Mingjun Bai, Tiantian Wang, Xiangwei Chen, Donghao Wu, Li Wei, Xing Li, Qu Lin, Jingyun Wen, Danyun Ruan, Zexiao Lin, Min Dong, Xiangyuan Wu
Background Albumin-to-Alkaline Phosphatase Ratio (ALB/ALP ratio, AAPR), a newly developed index of liver function, has been rarely discussed about its prognostic value in malignancies. The current study attempted to evaluate the prognostic prediction of AAPR in advanced HCC. Methods 237 advanced HCC patients who refused any standard anti-cancer therapies were retrospectively analyzed. The threshold value of AAPR was determined by receiver operating characteristic (ROC) curve. Univariate analyses using Kaplan-Meier method and log-rank test, and multivariate analysis using Cox proportional hazards regression model were conducted...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29284759/portomesenteric-venous-stenting-for-palliation-of-ascites-and-variceal-bleeding-caused-by-prehepatic-portal-hypertension
#4
Rahul A Sheth, Sharjeel H Sabir, Philip Parmet, Roshon Amin, Joshua D Kuban, Steven Y Huang, Armeen Mahvash, David Fogelman, Milind Javle, Michael J Wallace
BACKGROUND: The purpose of this study was to evaluate percutaneous transhepatic portal vein stenting (PVS) for palliation of refractory ascites and/or variceal bleeding caused by extrahepatic portomesenteric venous stenosis in patients with pancreaticobiliary cancer. MATERIALS AND METHODS: A single-institution, retrospective review of patients who underwent PVS between January 2007 and July 2015 was performed. A total of 38 patients were identified, of whom 28 met the inclusion criterion of PVS performed primarily for refractory ascites or variceal bleeding...
December 28, 2017: Oncologist
https://www.readbyqxmd.com/read/29279152/mri-features-and-score-for-differentiating-borderline-from-malignant-epithelial-ovarian-tumors
#5
Yong Ai Li, Jin Wei Qiang, Feng Hua Ma, Hai Ming Li, Shu Hui Zhao
PURPOSE: To identify the MRI features of borderline epithelial ovarian tumors (BEOTs) and to differentiate BEOTs from malignant epithelial ovarian tumors (MEOTs). MATERIALS AND METHODS: The clinical and MRI data of 89 patients with a BEOT and 109 patients with a MEOT proven by surgery and histopathology were retrospectively reviewed. MRI features, including bilaterality, size, shape, margin, cystic-solid interface, configuration, papillae or nodules, signal intensity, enhancement, presence of an ipsilateral ovary, peritoneal implants and ascites were analyzed and compared...
January 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29278233/does-size-matter-retrospective-analysis-of-large-gynecologic-tumors
#6
Tufan Öge, Emel Öztürk, Ömer T Yalçın
OBJECTIVE: To evaluate the characteristics of patients who underwent surgery due to the presence of a large pelvic-abdominal mass over a 5-year period in a university clinic. MATERIAL AND METHODS: Among 3476 gynecologic operations, intraoperative findings were evaluated retrospectively. Uterine and/or adnexal masses smaller than 20 cm were excluded to refine "large" tumors and 74 patients with large tumors were enrolled in the study group. Demographic characteristics, intraoperative findings, and results of histopathologic examinations were recorded...
December 15, 2017: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/29276230/disseminated-nontuberculous-mycobacterial-infection-in-a-patient-with-anti-ifn-%C3%AE-autoantibodies
#7
Masakuni Tanimizu, Kenji Mizuno, Masayuki Hashimoto
We treated a 72-year-old Japanese female with sustained high fever and overall body exhaustion. An infectious liver cyst and right lung pneumonia were suspected causes. Hepatic cystectomy and various antibiotics did not resolve symptoms. Pneumonia exacerbation and ascitic fluid retention, left lumbar spinal osteomyelitis, and peri-gastric lymph node abscess penetrating the stomach were observed. Mycobacterium avium was identified in sputum, ascites, vertebral body abscess puncture specimen, and pus mucus secretion in the stomach...
December 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/29274374/the-effect-of-subcellular-localization-on-the-efficiency-of-egfr-targeted-vhh-photosensitizer-conjugates
#8
Sanne A M van Lith, Dirk van den Brand, Rike Wallbrecher, Lina Wübbeke, Sander M J van Duijnhoven, Petri I Mäkinen, Janneke S Hoogstad-van Evert, Leon Massuger, Seppo Ylä-Herttuala, Roland Brock, William P J Leenders
Photodynamic therapy (PDT) is an emerging method to treat light-accessible malignancies. To increase specificity and allow dose reduction, conjugates of photosensitizers (PS) with antibodies against tumor-associated antigens have been developed for photoimmunotherapy (PIT). However, so far it is unclear whether cellular internalization of these conjugates after binding affects PIT efficacy. The use of low molecular weight llama single domain antibodies (VHHs, nanobodies) for PIT is preferred above full size antibodies because of better tumor penetration...
December 20, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29251272/endoscopic-ultrasound-guided-fine-needle-aspiration-from-ascites-and-peritoneal-nodules-a-scoping-review
#9
REVIEW
Vishal Sharma, Surinder Singh Rana, Sobur Uddin Ahmed, Sonali Guleria, Ravi Sharma, Rajesh Gupta
The peritoneum is involved in many diseases such as primary malignancy (mesothelioma), infectious disease (tuberculosis), and disseminated malignancy (peritoneal carcinomatosis). The peritoneal disease may manifest as ascites and/or peritoneal masses or nodules. Endoscopic ultrasound (EUS), due to its ability to provide high-resolution images, has revolutionized the imaging and diagnosis of pancreaticobiliary diseases among other gastrointestinal conditions. EUS can not only help in imaging of various lesions close to the gastrointestinal lumen but also aspirate/biopsy them...
November 2017: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/29250586/endoscopic-ultrasound-guided-placement-of-plastic-pigtail-stents-for-the-drainage-of-refractory-malignant-ascites
#10
Rafael Romero-Castro, Victoria Alejandra Jimenez-Garcia, Jaime Boceta-Osuna, Luis Castilla-Guerra, Francisco Pellicer-Bautista, Angel Caunedo-Alvarez, Juan Manuel Herrerias-Gutierrez, Manuel Romero-Gómez, Marc Giovannini
Endoscopic ultrasound (EUS)-guided drainage is now the treatment of choice in cases of pancreatic pseudocysts and walled-off necrosis, especially in the absence of luminal bulging and in patients with portal hypertension. Malignant refractory ascites usually heralds a poor prognosis and substantially impairs the quality of life of patients because of the symptoms experienced and the need for repeated paracentesis. EUS-guided placement of lumen-apposing, fully covered, self-expandable metal stents (FCSEMS) has been reported for the drainage of malignant ascites...
November 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29249858/symptomatic-fluid-drainage-peritoneovenous-shunt-placement
#11
REVIEW
Hooman Yarmohammadi, George I Getrajdman
Ascites causes significant discomfort and has negative impact on patient's quality of life. Medical therapies including dietary restriction and diuretics are successful in only 40 to 44% of patients with malignant ascites and repeated paracentesis only provides temporary symptomatic relief. Therefore, a more permanent solution is necessary. Indwelling catheters or peritoneovenous shunt placement can provide more permanent symptomatic relief and improve patients' quality of life. Unlike indwelling catheters, peritoneovenous shunts do not limit patients' life style and therefore should be offered as first option in patients who are good candidates...
December 2017: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/29249857/symptomatic-fluid-drainage-tunneled-peritoneal-and-pleural-catheters
#12
REVIEW
Tony Ha, David C Madoff, David Li
Malignant ascites and pleural effusion are significant contributors to patient symptoms such as shortness of breath, abdominal distension, and nausea in the setting of cancer. There are numerous methods employed to control such symptoms such as serial drainages, pleurodesis, and tunneled drainage catheters. Tunneled drainage catheters are a safe, effective, and a minimally invasive procedure to palliate the symptoms of malignant ascites and pleural effusion.
December 2017: Seminars in Interventional Radiology
https://www.readbyqxmd.com/read/29240604/potential-significance-of-peptidome-in-human-ovarian-cancer-for-patients-with-ascites
#13
Xiaohao Huang, Juan Zhou, Ranran Tang, Suping Han, Xue Zhou
OBJECTIVE: Ovarian cancer (OC) is one of the lethal gynecological malignancies. Most women affected by OC with malignant ascites will relapse. Peptidomics, as an emerging branch of proteomics, is more applied in screening of disease biomarkers, diagnosis, treatment, and monitoring. However, there is still little in-depth analysis about peptidomics study in OC with malignant ascites. METHODS: A comparative peptidomic profiling of ascites fluid between 6 OC patients and 6 benign gynecological conditions using liquid chromatography-tandem mass spectrometry was analyzed...
December 13, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29229600/genomic-and-epigenomic-signatures-in-ovarian-cancer-associated-with-re-sensitization-to-platinum-drugs
#14
Fang Fang, Horacio Cardenas, Hao Huang, Guanglong Jiang, Susan M Perkins, Chi Zhang, Harold N Keer, Yunlong Liu, Kenneth P Nephew, Daniela Matei
DNA methylation aberrations have been implicated in acquired resistance to platinum drugs in ovarian cancer (OC). In this study, we elucidated an epigenetic signature associated with platinum drug re-sensitization that may offer utility in predicting the outcomes of patients who are co-administered a DNA methyltransferase inhibitror. The OC specimens we analyzed were derived from a recent clinical trial that compared the responses of patients with recurrent platinum-resistant OC who received carboplatin plus the DNA methyltransferase inhibitor guadecitabine or a standard of care chemotherapy regimen selected by the treating physician...
December 11, 2017: Cancer Research
https://www.readbyqxmd.com/read/29227858/bilateral-ovarian-angiosarcoma-arising-from-the-mature-cystic-teratomas-a-case-report-and-review-of-the-literature
#15
Erik Kudela, Marcela Nachajova, Kamil Biringer, Pavol Slavik, Lukas Plank, Jan Danko
INTRODUCTION: Ovarian teratomas undergo the malignant transformation in 0.2-2% of cases. The behavior of malignancies in mature cystic teratomas (MCT) is determined by their phenotype and not their derivation from germ cells. We can recognize pure angiosarcomas or as a part of other tumors like malignant mixed Mullerian tumors and adenosarcomas. PRESENTATION OF CASE: We present the first case of bilateral ovarian angiosarcoma arising from the mature teratomas. Due to widespread disease, we performed limited surgical procedure consisting of bilateral adnexectomy and omentectomy...
December 7, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29224266/-application-of-liver-three-dimensional-visualization-technologies-in-the-treatment-planning-of-hepatic-malignant-tumor
#16
P P Li, Z H Wang, G Huang, Z P Huang, Y Li, J S Ni, H Liu, C H Fang, W P Zhou
Objective: To discuss the application of three dimentional(3D)visualization technologies in treatment plan of hepatic malignant tumor. Methods: The clinical data of 300 patients with liver malignant tumor who received treatment from January 2016 to January 2017 in the Third Department of Hepatic Surgery of Eastern Hepatobiliary Surgery Hospital was retrospectively analyzed in this study, including 221 male and 79 female patients aged from 7 to 76 years with median age of 54 years. The median height was 168 cm (115-183 cm), the median weight was 65 kg (20-105 kg) and the median tumor volume was 142 ml (23-2 493 ml)...
December 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29207182/antitumor-activity-of-the-synthetic-retinoid-st1926-on-primary-effusion-lymphoma-in-vitro-and-in-vivo-models
#17
Louna Karam, Bilal Houshaymi, Rana Abdel-Samad, Mariam Jaafar, Iman Halloum, Claudio Pisano, Frank Neipel, Nadine Darwiche, Raghida Abou Merhi
Primary effusion lymphoma (PEL) is a rare B-cell neoplasm, associated with Kaposi sarcoma-associated herpes virus/human herpes virus-8 (KSHV/HHV-8), arising as malignant effusions in body cavities. PEL cells do not harbor conventional genetic cancer mutations; however, their oncogenesis is mainly attributed to HHV-8 latent genes. Treatment strategies are inefficient resulting in poor prognosis of PEL patients, stressing the need for new effective therapy. ST1926 is a synthetic retinoid with favorable antitumor properties and no cross-resistance with the natural retinoid, all-trans retinoic acid...
December 5, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29194291/the-great-mimicker-pseudo-meig-syndrome-in-a-pregnant-patient-a-review
#18
Thelina Amaratunga, Noam Millo, Vallerie Gordon, Cyrille Blcamumpaka, Yi Yan, Stephanie Sparkes, Ashraf Goubran
Meig syndrome is the triad of benign ovarian tumor, ascites, and pleural effusion. Pseudo-Meig syndrome mimics the Meig syndrome triad; however, in pseudo-Meig syndrome, the ovarian tumor usually represents a primary malignancy or metastases. Differentiating Meig from pseudo-Meig syndrome is challenging both clinically and with diagnostic imaging but is important because prognoses for these distinct entities are drastically different. Evidence-based sonographic prediction models are valuable because they can aid in this distinction...
November 29, 2017: Ultrasound Quarterly
https://www.readbyqxmd.com/read/29193587/phlebotomy-as-a-preventive-measure-for-crocidolite-induced-mesothelioma-in-male-rats
#19
Yuuki Ohara, Shan-Hwu Chew, Takahiro Shibata, Yasumasa Okazaki, Kyoko Yamashita, Shinya Toyokuni
Malignant mesothelioma (MM) is a rare but socially important neoplasm due to its association with asbestos exposure. While MM is difficult to diagnose at an early stage, there are no particularly effective treatments available at the advanced stage, thus necessitating efficient strategies to prevent MM in individuals already exposed to asbestos. We previously showed that persistent oxidative damage caused by foreign body reaction and affinity of asbestos both to hemoglobin and histones is one of the major pathogeneses...
November 29, 2017: Cancer Science
https://www.readbyqxmd.com/read/29192324/a-novel-mechanism-of-neovascularization-in-peritoneal-dissemination-via-cancer-associated-mesothelial-cells-affected-by-tgf-%C3%AE-derived-from-ovarian-cancer
#20
Kayo Fujikake, Hiroaki Kajiyama, Masato Yoshihara, Kimihiro Nishino, Nobuhisa Yoshikawa, Fumi Utsumi, Shiro Suzuki, Kaoru Niimi, Jun Sakata, Hiroko Mitsui, Kiyosumi Shibata, Takeshi Senga, Fumitaka Kikkawa
Epithelial ovarian cancer (EOC) is believed to cause peritoneum dissemination through microenvironmental cell‑to-cell communication between the tumor and mesothelium, leading to the further acquisition of progressive and metastatic potentials. In the present study, we aimed to determine the role of cancer-associated mesothelial cells (CAMCs) in the promotion of tumor neovascularization and vascular permeability via enhanced vascular endothelial growth factor (VEGF) production. We examined whether a characteristic morphological change in human peritoneal mesothelial cells (HPMCs) was observed in the presence of malignant ascites and tumor-derived TGF-β...
January 2018: Oncology Reports
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