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https://www.readbyqxmd.com/read/28210777/effects-of-biperiden-and-acute-tryptophan-depletion-and-their-combination-on-verbal-word-memory-and-eeg
#1
Laura G J M Borghans, Arjan Blokland, Anke Sambeth
BACKGROUND: Research on the neurobiological foundations of memory has shown that multiple neurotransmitters play an important role in memory processing. To study the interaction between neurotransmitters such as acetylcholine and serotonin, pharmacological models can be used. In this study, we tested the effects of the muscarinic M1 antagonist biperiden, acute tryptophan depletion (ATD), and the interaction between the two on episodic memory using the verbal learning task. METHODS: The study was conducted according to a double-blind, placebo-controlled, four-way crossover design...
February 16, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28206782/process-dissociation-analyses-of-memory-changes-in-healthy-aging-preclinical-and-very-mild-alzheimer-disease-evidence-for-isolated-recollection-deficits
#2
Peter R Millar, David A Balota, Geoffrey B Maddox, Janet M Duchek, Andrew J Aschenbrenner, Anne M Fagan, Tammie L S Benzinger, John C Morris
OBJECTIVE: Recollection and familiarity are independent processes that contribute to memory performance. Recollection is dependent on attentional control, which has been shown to be disrupted in early stage Alzheimer's disease (AD), whereas familiarity is independent of attention. The present longitudinal study examines the sensitivity of recollection estimates based on Jacoby's (1991) process dissociation procedure to AD-related biomarkers in a large sample of well-characterized cognitively normal middle-aged and older adults (N = 519) and the extent to which recollection discriminates these individuals from individuals with very mild symptomatic AD (N = 64)...
February 16, 2017: Neuropsychology
https://www.readbyqxmd.com/read/28195953/cross-validation-of-a-classification-system-for-persons-with-traumatic-brain-injury-in-the-posthospital-period
#3
Mark Sherer, Jennie Ponsford, Amelia Hicks, Luis Leon-Novelo, Esther Ngan, Angelle M Sander
OBJECTIVE: To (1) identify groupings of persons with traumatic brain injury (TBI) in the posthospital period in a cohort recruited in Australia; (2) compare groupings from the Australian cohort to groupings previously developed for a US cohort. SETTING: Rehabilitation centers in the US and Australia. PARTICIPANTS: A total of 170 persons with TBI from Australia and 504 persons with TBI from the United States. Participants were aged 18 to 64 years, greater than 6 months postinjury, had capacity to give consent, and had definitive contemporaneous medical evidence of TBI...
February 10, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28194105/erp-subsequent-memory-effects-differ-between-inter-item-and-unitization-encoding-tasks
#4
Siri-Maria Kamp, Regine Bader, Axel Mecklinger
The "subsequent memory paradigm" is an analysis tool to identify brain activity elicited during episodic encoding that is associated with successful subsequent retrieval. Two commonly observed event-related potential "subsequent memory effects" (SMEs) are the parietal SME in the P300 time window and the frontal slow wave SME, but to date a clear characterization of the circumstances under which each SME is observed is missing. To test the hypothesis that the parietal SME occurs when aspects of an experience are unitized into a single item representation, while inter-item associative encoding is reflected in the frontal slow wave effect, participants were assigned to one of two conditions that emphasized one of the encoding types under otherwise matched study phases of a recognition memory experiment...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28191647/flexible-conceptual-combination-electrophysiological-correlates-and-consequences-for-associative-memory
#5
Heather D Lucas, Ryan J Hubbard, Kara D Federmeier
When meaningful stimuli such as words are encountered in groups or pairs (e.g., "elephant-ferry"), they can be processed either separately or as an integrated concept ("an elephant ferry"). Prior research suggests that memory for integrated associations is supported by different mechanisms than is memory for nonintegrated associations. However, little is known about the neurocognitive mechanisms that support the integration of novel stimulus pairs. We recorded ERPs while participants memorized sequentially presented, unrelated noun pairs using a strategy that either did or did not involve attempting to construct coherent definitions...
February 13, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28190942/cognitive-and-linguistic-predictors-of-mathematical-word-problems-with-and-without-irrelevant-information
#6
Amber Y Wang, Lynn S Fuchs, Douglas Fuchs
The purpose of this study was to identify cognitive and linguistic predictors of word problems with versus without irrelevant information. The sample was 701 2nd-grade students who received no specialized intervention on word problems. In the fall, they were assessed on initial arithmetic and word-problem skill as well as language ability, working memory capacity, and processing speed; in the spring, they were tested on a word-problem measure that included items with versus without irrelevant information. Significant predictors common to both forms of word problems were initial arithmetic and word problem-solving skill as well as language and working memory...
December 2016: Learning and Individual Differences
https://www.readbyqxmd.com/read/28188665/memory-for-relations-in-the-short-term-and-the-long-term-after-medial-temporal-lobe-damage
#7
Larry R Squire
A central idea about the organization of declarative memory and the function of the hippocampus is that the hippocampus provides for the coding of relationships between items. A question arises whether this idea refers to the process of forming long-term memory or whether, as some studies have suggested, memory for relations might depend on the hippocampus even at short retention intervals and even when the task falls within the province of short-term (working) memory. The latter formulation appears to place the operation of relational memory into conflict with the idea that working memory is independent of medial temporal lobe (MTL) structures...
February 11, 2017: Hippocampus
https://www.readbyqxmd.com/read/28182480/are-portrait-artists-superior-face-recognizers-limited-impact-of-adult-experience-on-face-recognition-ability
#8
Jeremy J Tree, Ruth Horry, Howard Riley, Jeremy B Wilmer
Across 2 studies, the authors asked whether extensive experience in portrait art is associated with face recognition ability. In Study 1, 64 students completed a standardized face recognition test before and after completing a year-long art course that included substantial portraiture training. They found no evidence of an improvement in face recognition after training over and above what would be expected by practice alone. In Study 2, the authors investigated the possibility that more extensive experience might be needed for such advantages to emerge, by testing a cohort of expert portrait artists (N = 28), all of whom had many years of experience...
February 9, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/28179554/are-there-multiple-kinds-of-episodic-memory-an-fmri-investigation-comparing-autobiographical-and-recognition-memory-tasks
#9
Hung-Yu Chen, Adrian W Gilmore, Steven M Nelson, Kathleen B McDermott
What brain regions underlie retrieval from episodic memory? The bulk of research addressing this question with fMRI has relied upon recognition memory for materials encoded within the laboratory. Another, less dominant tradition has employed autobiographical methods, whereby people recall events from their lifetime, often after being cued with words or pictures. The current study addressed how the neural substrates of successful memory retrieval differ as a function of the targeted memory when the experimental parameters were held constant in the two conditions (except for instructions)...
February 8, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28178738/core-executive-functions-are-associated-with-success-in-young-elite-soccer-players
#10
Torbjörn Vestberg, Gustaf Reinebo, Liselotte Maurex, Martin Ingvar, Predrag Petrovic
Physical capacity and coordination cannot alone predict success in team sports such as soccer. Instead, more focus has been directed towards the importance of cognitive abilities, and it has been suggested that executive functions (EF) are fundamentally important for success in soccer. However, executive functions are going through a steep development from adolescence to adulthood. Moreover, more complex EF involving manipulation of information (higher level EF) develop later than simple executive functions such as those linked to simple working memory capacity (Core EF)...
2017: PloS One
https://www.readbyqxmd.com/read/28173964/sleep-deprivation-disrupts-the-contribution-of-the-hippocampus-to-the-formation-of-novel-lexical-associations
#11
Virginie Sterpenich, Leonardo Ceravolo, Sophie Schwartz
Sleep is involved in the mechanisms underlying memory consolidation and brain plasticity. Consolidation refers to a process through which labile memories are reorganized into more stable ones. An intriguing but often neglected question concerns how pre-existing knowledge is modified when new information enters memory, and whether sleep can influence this process. We investigated how nonword learning may modify the neural representations of closely-related existing words. We also tested whether sleep contributes to any such effect by comparing a group of participants who slept during the night following a first encoding session to a sleep deprived group...
February 4, 2017: Brain and Language
https://www.readbyqxmd.com/read/28168651/the-effects-of-context-in-item-based-directed-forgetting-evidence-for-one-shot-context-storage
#12
Nicole Burgess, William E Hockley, Kathleen L Hourihan
The effects of context on item-based directed forgetting were assessed. Study words were presented against different background pictures and were followed by a cue to remember (R) or forget (F) the target item. The effects of incidental and intentional encoding of context on recognition of the study words were examined in Experiments 1 and 2. Recognition memory for the picture contexts was assessed in Experiments 3a and 3b. Recognition was greater for R-cued compared to F-cued targets, demonstrating an effect of directed forgetting...
February 6, 2017: Memory & Cognition
https://www.readbyqxmd.com/read/28164725/applying-psycholinguistic-evidence-to-the-construction-of-a-new-test-of-verbal-memory-in-late-life-cognitive-decline
#13
Johannes Baltasar Hessler, David Brieber, Johanna Egle, Georg Mandler, Thomas Jahn
The construction of the German Auditory Wordlist Learning Test (AWLT) for the assessment of verbal memory in late-life cognitive decline was guided by psycholinguistic evidence, which indicates that a word's linguistic characteristics influence its probability of being learned and recalled. The AWLT includes four trials of learning, short and long delayed free recall, and a recognition task. Its words were selected with taking into account their semantic content, orthographic length, frequency in the language, and orthographic neighborhood size (the number of words derived by adding, subtracting, or replacing a single letter at a time)...
February 1, 2017: Assessment
https://www.readbyqxmd.com/read/28163506/related-factors-and-predictors-of-cognitive-dysfunction-in-chronic-kidney-disease-on-maintenance-hemodialysis-in-nigeria
#14
Lukman Femi Owolabi, Aliyu Abdu, Aliyu Ibrahim, Desola Shakirah Owolabi, Aisha Nalado, Adamu Bappa, Aminu Abdullahi Taura
BACKGROUND: Previous studies suggest a high frequency of cognitive impairment (CI) in persons with chronic kidney disease (CKD); however, factors associated with CI and predictors of CI in persons with CKD remain largely unclear. The aim of this study was to determine the factors associated with CI and predictors of CI in CKD patients on maintenance hemodialysis. MATERIALS AND METHODS: The first stage of the study included recruitment of 100 apparently healthy participants aimed at determining the reference values...
December 2016: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28161030/brain-behavior-relationships-in-source-memory-effects-of-age-and-memory-ability
#15
Liesel-Ann Meusel, Cheryl L Grady, Patricia E Ebert, Nicole D Anderson
There is considerable evidence for age-related decrements in source memory retrieval, but the literature on the neural correlates of these impairments is mixed. In this study, we used functional magnetic resonance imaging to examine source memory retrieval-related brain activity, and the monotonic relationship between retrieval-related brain activity and source memory accuracy, as a function of both healthy aging (younger vs older) and memory ability within the older adult group (Hi-Old vs Lo-Old). Participants studied lists of word pairs, half visually, half aurally; these were re-presented visually in a scanned test phase and participants indicated if the pair was 'seen' or 'heard' in the study phase...
January 12, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28160034/the-effects-of-synthetic-cannabinoids-on-executive-function
#16
K Cohen, M Kapitány-Fövény, Y Mama, M Arieli, P Rosca, Z Demetrovics, A Weinstein
BACKGROUND AND AIMS: There is a growing use of novel psychoactive substances (NPSs) including synthetic cannabinoids. Synthetic cannabinoid products have effects similar to those of natural cannabis but the new synthetic cannabinoids are more potent and dangerous and their use has resulted in various adverse effects. The purpose of the study was to assess whether persistent use of synthetic cannabinoids is associating with impairments of executive function in chronic users. METHODS: A total of 38 synthetic cannabinoids users, 43 recreational cannabis users, and 41 non-user subjects were studied in two centers in Hungary and Israel...
February 3, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28158153/trigeminal-neuralgia-induced-by-cobra-venom-leads-to-cognitive-deficits-associated-with-downregulation-of-creb-bdnf-pathway
#17
Li Zhang, Xinli Ding, Zhe Wu, Xiaoyan Qian, Jianxiong An, Ming Tian
BACKGROUND: Chronic pain often results in cognitive impairment. Our previous study showed that trigeminal neuralgia induced by cobra venom leads to spatial learning and memory deficits, although the underlying mechanism remains unclear. However, recent evidence indicates that the c-AMP-responsive element binding protein (CREB)/brain derived neurotrophic factor (BDNF) pathway plays a critical role in various etiologies of cognitive deficits. OBJECTIVES: Our aim was to explore the CREB/BDNF pathway to determine the molecular mechanisms involved in the pathogenesis of cognitive impairment caused by cobra venom-induced trigeminal neuralgia...
February 2017: Pain Physician
https://www.readbyqxmd.com/read/28156190/the-visual-association-test-extended-a-cross-sectional-study-of-the-performance-validity-measures
#18
Sascha R A Meyer, Jos F M de Jonghe, Ben Schmand, Rudolf W H M Ponds
OBJECTIVE: Given the hazards of knowledge about performance validity tests (PVTs) being proliferated among the general public, there is a continuous need to develop new PVTs. The purpose of these studies was to validate the newly developed Visual Association Test-Extended (VAT-E). METHOD: The VAT-E consists of 24 pairs of line drawings; it is partly based on Green's Word Memory Test (WMT) paradigm. In study 1, we compared VAT-E total scores of healthy controls (n = 226), patients with mild cognitive impairment (MCI) (n = 76), patients with Alzheimer's disease (AD) (n = 26), and persons instructed to feign memory deficit (n = 29)...
February 3, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28153503/intake-of-tryptophan-enriched-whey-protein-acutely-enhances-recall-of-positive-loaded-words-in-patients-with-multiple-sclerosis
#19
Cindy K Lieben, Arjan Blokland, Nicolaas E Deutz, Willemijn Jansen, Gang Han, Raymond M Hupperts
BACKGROUND & AIMS: Multiple sclerosis (MS) has physiological and/or immunological characteristics that diminish serotonin metabolism, a neurotransmitter associated with affective and cognitive functions. The aim was examine the acute and dose-dependent effects of a dietary tryptophan (TRP) enrichment on affective and cognitive functions in MS patients. We hypothesized that increased dietary availability of the amino acid TRP enhances serotonin concentrations and improves neuropsychological functions...
January 16, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28143960/targeted-reactivation-during-sleep-differentially-affects-negative-memories-in-socially-anxious-and-healthy-children-and-adolescents
#20
S Groch, A Preiss, D McMakin, B Rasch, S Walitza, R Huber, I Wilhelm
: Cognitive models propose a negative memory bias as one key factor contributing to the emergence and maintenance of social anxiety disorder (SAD). The long-term consolidation of memories relies on memory reactivations during sleep. We investigated in SAD patients and healthy controls the role of memory reactivations during sleep in the long-term consolidation of positive and negative information. Socially anxious and healthy children and adolescents learnt associations between pictures showing ambiguous situations and positive or negative words defining the situations' outcome...
January 31, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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