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Garcinia Kola

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https://www.readbyqxmd.com/read/27842536/antibacterial-and-cytotoxic-cytochalasins-from-the-endophytic-fungus-phomopsis-sp-harbored-in-garcinia-kola-heckel-nut
#1
Jean-Bosco Jouda, Jean-de-Dieu Tamokou, Céline Djama Mbazoa, Clovis Douala-Meli, Prodipta Sarkar, Prasanta Kumar Bag, Jean Wandji
BACKGROUND: The continuous emergence of multidrug-resistant (MDR) bacteria drastically reduced the efficacy of our antibiotic armory and consequently, increased the frequency of therapeutic failure. The search for bioactive constituents from endophytic fungi against MDR bacteria became a necessity for alternative and promising strategies, and for the development of novel therapeutic solutions. We report here the isolation and structure elucidation of antibacterial and cytotoxic compounds from Phomopsis sp...
November 14, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27825990/garcinia-kola-aqueous-suspension-prevents-cerebellar-neurodegeneration-in-long-term-diabetic-rat-a-type-1-diabetes-mellitus-model
#2
Mohammed Farahna, Paul F Seke Etet, Sayed Y Osman, Kıymet K Yurt, Naheed Amir, Lorella Vecchio, Isınsu Aydin, Yousef H Aldebasi, Azimullah Sheikh, John C Chijuka, Süleyman Kaplan, Abdu Adem
ETHNOPHARMACOLOGICAL RELEVANCE: The development of compounds able to improve metabolic syndrome and mitigate complications caused by inappropriate glycemic control in type 1 diabetes mellitus is challenging. The medicinal plant with established hypoglycemic properties Garcinia kola Heckel might have the potential to mitigate diabetes mellitus metabolic syndrome and complications. AIM OF THE STUDY: We have investigated the neuroprotective properties of a suspension of G...
November 5, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27788191/preparation-and-response-to-the-2014-ebola-virus-disease-epidemic-in-nigeria-the-experience-of-a-tertiary-hospital-in-nigeria
#3
Dimie Ogoina, Abisoye Sunday Oyeyemi, Okubusa Ayah, Austin Onabor A, Adugo Midia, Wisdom Tudou Olomo, Onyaye E Kunle-Olowu
INTRODUCTION: The 2014 Ebola Virus Disease (EVD) outbreak elicited global attention and challenged health systems around the world, Nigeria inclusive. We hereby report the preparation and response to the outbreak by a tertiary teaching hospital in Bayelsa State, Nigeria. METHOD: Between 4th August and 31st October 2014, we conducted a mixed cross sectional and qualitative study to ascertain the EVD-related fear, myths and misconceptions among healthcare workers (HCWs), and to evaluate the plans, activities and challenges faced by the hospital during the outbreak...
2016: PloS One
https://www.readbyqxmd.com/read/27686270/three-indigenous-plants-used-in-anti-cancer-remedies-garcinia-kola-heckel-stem-bark-uvaria-chamae-p-beauv-root-and-olax-subscorpioidea-oliv-root-show-analgesic-and-anti-inflammatory-activities-in-animal-models
#4
Temidayo D Popoola, Olufunsho Awodele, Adeola Omisanya, Nkechinyerem Obi, Chioma Umezinwa, Amos A Fatokun
ETHNOPHARMACOLOGICAL RELEVANCE: Phytochemicals with anti-oxidative and anti-inflammatory properties are known to inhibit tumour initiation, promotion and progression. Hence, there is an increasingly-convincing rationale for employing remedies containing those phytochemicals in the treatment of cancers and also as analgesic and anti-inflammatory adjuvants in therapy. The plants Garcinia kola Heckel (Clusiaceae), stem bark; Uvaria chamae P. Beauv. (Annonaceae), root; and Olax subscorpioidea Oliv...
September 26, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27631100/ameliorative-effect-of-kolaviron-a-biflavonoid-complex-from-garcinia-kola-seeds-against-scopolamine-induced-memory-impairment-in-rats-role-of-antioxidant-defense-system
#5
Ismail O Ishola, Folasade M Adamson, Olufunmilayo O Adeyemi
In Alzheimer's disease (AD) basal forebrain cholinergic neurons appear to be targeted primarily in early stages of the disease. Scopolamine (muscarinic receptor antagonist) has been used for decades to induce working and reference memory impairment in rodents. In this study, we evaluated the protective effect of kolaviron, a biflavonoid complex isolated from Garcinia kola seeds extract against scopolamine-induced memory impairment/oxidative stress. Rats were pretreated with kolaviron (25, 50 or 100 mg/kg p...
September 8, 2016: Metabolic Brain Disease
https://www.readbyqxmd.com/read/27599375/effect-of-kolaviron-a-biflavanoid-complex-from-garcinia-kola-on-some-biochemical-parameters-in-experimentally-induced-benign-prostatic-hyperplasic-rats
#6
W O Kalu, P N Okafor, I I Ijeh, C Eleazu
BACKGROUND: To determine the effect of kolaviron on some biochemical parameters in benign prostatic hyperplasia (BPH) rats. METHODS: BPH was induced in rats using a mixture of dihydrotestosterone and estradiol valerate (10:1). RESULTS: The lethal dose of kolaviron was 3050mg/kg body weight. Body weights, relative heart weight (RHW), relative liver weight (RLW), serum levels of prostate specific antigen, prolactin, estradiol, testosterone, testosterone/estradiol ratio, aspartate transaminase (AST), alanine transaminase (ALT), urea, creatinine and prostatic levels of total proteins in the normal rats administered finasteride (standard drug) or kolaviron were not different (P>0...
September 3, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27548501/protective-effects-of-kolaviron-and-gallic-acid-against-cobalt-chloride-induced-cardiorenal-dysfunction-via-suppression-of-oxidative-stress-and-activation-of-the-erk-signaling-pathway
#7
Akinleye Stephen Akinrinde, Olutayo Omobowale, Ademola Oyagbemi, Ebunoluwa Asenuga, Temitayo Ajibade
Cobalt (Co) toxicity is a potential public health problem due to recent renewed use of Co in orthopedic implants, dietary supplements, and blood doping in athletes and horses. We investigated the protective roles of kolaviron (KV), a bi-flavonoid of Garcinia kola, and gallic acid (GA) on cobalt chloride (CoCl2)-induced cardiorenal damage in rats. CoCl2 caused significant increases (p < 0.05) in serum creatine kinase-myocardial band (CK-MB), lactate dehydrogenase (LDH), aspartate transaminase (AST), xanthine oxidase (XO), urea, creatinine, malondialdehyde, H2O2, nitric oxide, as well as C-reactive protein expression, along with significant (p < 0...
July 5, 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/27343901/fingerprinting-and-validation-of-a-lc-dad-method-for-the-analysis-of-biflavanones-in-garcinia-kola-based-antimalarial-improved-traditional-medicines
#8
P Tshisekedi Tshibangu, P Mutwale Kapepula, M J Kabongo Kapinga, H Kabika Lupona, N Kabamba Ngombe, Dibungi T Kalenda, O Jansen, J N Wauters, M Tits, L Angenot, E Rozet, Ph Hubert, R D Marini, M Frédérich
African populations use traditional medicines in their initial attempt to treat a range of diseases. Nevertheless, accurate knowledge of the composition of these drugs remains a challenge in terms of ensuring the health of population and in order to advance towards improved traditional medicines (ITMs). In this paper chromatographic methods were developed for qualitative and quantitative analyses of a per os antimalarial ITM containing Garcinia kola. The identified analytical markers were used to establish TLC and HPLC fingerprints...
September 5, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27286327/semisynthetic-and-natural-garcinoic-acid-isoforms-as-new-mpges-1-inhibitors
#9
Khaled Alsabil, Sorphon Suor-Cherer, Andreas Koeberle, Guillaume Viault, Alexis Lavaud, Veronika Temml, Birgit Waltenberger, Daniela Schuster, Marc Litaudon, Stefan Lorkowski, René de Vaumas, Jean-Jacques Helesbeux, David Guilet, Hermann Stuppner, Oliver Werz, Denis Seraphin, Pascal Richomme
Over the last twenty years, tocotrienol analogues raised great interest because of their higher level and larger domain of biological activities when compared with tocopherols. Amongst the most promising therapeutic application, anti-inflammatory potency has been evaluated through the inhibition of various mediators of inflammation. Here, we worked on the isolation of two natural isoforms of garcinoic acid (i.e., δ and γ) from two different sources, respectively, Garcinia kola seeds and Garcinia amplexicaulis bark...
July 2016: Planta Medica
https://www.readbyqxmd.com/read/27114693/kolaviron-biflavonoid-complex-from-the-seed-of-garcinia-kola-attenuated-angiotensin-ii-and-lypopolysaccharide-induced-vascular-smooth-muscle-cell-proliferation-and-nitric-oxide-production
#10
Ademola Adetokunbo Oyagbemi, Temidayo Olutayo Omobowale, Adeolu Alex Adedapo, Momoh Audu Yakubu
INTRODUCTION: Kolaviron (KV), a biflavonoid extract from Garcinia kola seeds has been reported to possess anti-inflammatory, anti-oxidant, hepato-protective, cardio-protective, nephro-protective and other arrays of chemopreventive capabilities but the mechanism of action is still not completely understood. MATERIALS AND METHODS: In this study, we investigated the anti-proliferative, anti-inflammatory and anti-oxidative potential of KV in cultured Vascular Smooth Muscle Cells (VSMCs)...
March 2016: Pharmacognosy Research
https://www.readbyqxmd.com/read/27089414/biflavonoid-fraction-from-garcinia-kola-seed-ameliorates-hormonal-imbalance-and-testicular-oxidative-damage-by-anti-tuberculosis-drugs-in-wistar-rats
#11
Aderemi Kehinde, Adedoyin Adefisan, Olayinka Adebayo, Oluwatosin Adaramoye
BACKGROUND: Tuberculosis (TB) is a global health problem. The effects of anti-TB drugs on male reproductive system have not been properly evaluated. We investigated the effects of anti-TB drugs on testicular antioxidant indices, sperm characteristics and hormonal levels in rats, and the protective role of kolaviron (KV), a biflavonoid from Garcinia kola seed. METHODS: Twenty-eight male Wistar rats were assigned into four groups and orally treated with corn oil (control), anti-TB drugs [4-Tabs=isoniazid (5 mg/kg), rifampicin (10 mg/kg), pyrazinamide (15 mg/kg) and ethambutol (15 mg/kg) in combination], anti-TB drugs +KV and KV alone (200 mg/kg)...
June 1, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/27050890/ameliorative-effects-of-kolaviron-a-biflavonoid-fraction-from-garcinia-kola-seed-on-hepato-renal-toxicity-of-anti-tuberculosis-drugs-in-wistar-rats
#12
Oluwatosin A Adaramoye, Aderemi O Kehinde, Adedoyin Adefisan, Olugbenga Adeyemi, Idowu Oyinlola, Olubukola O Akanni
BACKGROUND: Tuberculosis (TB) is an infectious disease of international health priority. The combination of anti-TB drugs (4-Tabs)- isoniazid (INH), rifampicin (RIF), pyrazinamide (PZA) and ethambutol (ETB) are effective in the management of the disease, however, their toxic effect is a major concern. PURPOSE: The study was designed to evaluate the toxicity of anti-TB drugs in male Wistar rats and possible ameliorative effects of kolaviron (KV), a biflavonoid from Garcinia kola seeds...
April 2016: Tokai Journal of Experimental and Clinical Medicine
https://www.readbyqxmd.com/read/27016075/vitamin-e-metabolite-13-carboxychromanols-inhibit-pro-inflammatory-enzymes-induce-apoptosis-and-autophagy-in-human-cancer-cells-by-modulating-sphingolipids-and-suppress-colon-tumor-development-in-mice
#13
Yumi Jang, Na-Young Park, Agnetha Linn Rostgaard-Hansen, Jianjie Huang, Qing Jiang
Vitamin E forms are substantially metabolized to various carboxychromanols including 13'-carboxychromanols (13'-COOHs) that are found at high levels in feces. However, there is limited knowledge about functions of these metabolites. Here we studied δT-13'-COOH and δTE-13'-COOH, which are metabolites of δ-tocopherol and δ-tocotrienol, respectively. δTE-13'-COOH is also a natural constituent of a traditional medicine Garcinia Kola. Both 13'-COOHs are much stronger than tocopherols in inhibition of pro-inflammatory and cancer promoting cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX), and in induction of apoptosis and autophagy in colon cancer cells...
June 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/26838169/inhibition-of-neuroinflammation-in-bv2-microglia-by-the-biflavonoid-kolaviron-is-dependent-on-the-nrf2-are-antioxidant-protective-mechanism
#14
Samuel A Onasanwo, Ravikanth Velagapudi, Abdelmeneim El-Bakoush, Olumayokun A Olajide
Kolaviron is a mixture of biflavonoids found in the nut of the West African edible seed Garcinia kola, and it has been reported to exhibit a wide range of pharmacological activities. In this study, we investigated the effects of kolaviron in neuroinflammation. The effects of kolaviron on the expression of nitric oxide/inducible nitric oxide synthase (iNOS), prostaglandin E2 (PGE2)/cyclooxygenase-2, cellular reactive oxygen species (ROS) and the pro-inflammatory cytokines were examined in lipopolysaccharide (LPS)-stimulated BV2 microglial cells...
March 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/26812784/antinociceptive-and-anti-inflammatory-potentials-of-kolaviron-mechanisms-of-action
#15
Samuel A Onasanwo, Rume A Rotu
BACKGROUND: Major attention has been on dietary and medicinal phytochemicals that inhibit or reverse abnormal conditions caused by nociceptive and inflammatory stimuli. Garcinia kola (Guttiferae) seed, known as "bitter kola", plays an important role in African ethno-medicine and traditional hospitality like in the treatment of inflammation, colds, bronchitis, bacterial, and viral infections. A number of useful phytochemicals have been isolated from the seed, and the most prominent of them is kolaviron (Garcinia bioflavonoid), which has been suggested to have antinociceptive and anti-inflammatory potentials...
June 1, 2016: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/26280929/kolaviron-protects-against-benzo-a-pyrene-induced-functional-alterations-along-the-brain-pituitary-gonadal-axis-in-male-rats
#16
Isaac A Adedara, Olatunde Owoeye, Motunrayo A Aiyegbusi, Joshua O Dagunduro, Yetunde M Daramola, Ebenezer O Farombi
Exposure to benzo[a]pyrene (B[a]P) is well reported to be associated with neurological and reproductive dysfunctions. The present study investigated the influence of kolaviron, an isolated biflavonoid from the seed of Garcinia kola, on functional alterations along the brain-pituitary-gonadal axis in male rats exposed to B[a]P. Benzo[a]pyrene was orally administered at a dose of 10mg/kg alone or orally co-administered with kolaviron at 100 and 200mg/kg for 15 consecutive days. Administration of B[a]P significantly (p<0...
September 2015: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/26200137/kolaviron-improves-morbidity-and-suppresses-mortality-by-mitigating-oxido-inflammation-in-balb-c-mice-infected-with-influenza-virus
#17
Ifeoluwa O Awogbindin, David O Olaleye, Ebenezer O Farombi
Influenza A viruses (IAV) induce cytokine storm and host's intracellular redox imbalance to ensure continuous replication and survival, leading to severe immunopathology and death. The unpredictability of broad-spectrum vaccines, the emergence of drug-resistant and/or more virulent strains, the prevalence of the amantadane-resistant IAV, and the prohibitive cost of available drugs especially in resource-poor countries necessitate exploring drugs with novel action mechanisms as anti-influenza agents. This study presents the protective role of kolaviron (KV), a natural antioxidant and anti-inflammatory agent from Garcinia kola seeds, on BALB/c mice challenged with influenza A/Perth/H3N2/16/09 (Pr/H3N2) virus...
September 2015: Viral Immunology
https://www.readbyqxmd.com/read/26179065/effects-of-kolaviron-on-hepatic-oxidative-stress-in-streptozotocin-induced-diabetes
#18
Omolola R Oyenihi, Nicole L Brooks, Oluwafemi O Oguntibeju
BACKGROUND: Alteration in antioxidant defence and increase in oxidative stress that results in tissue injury is characteristic of diabetes. We evaluated the protective effects of kolaviron (a flavonoid complex extracted from the seeds of Garcinia kola) on hepatic antioxidants, lipid peroxidation and apoptosis in diabetic rats. METHODS: To induce diabetes, rats were injected with streptozotocin intraperitoneally at a single dose of 50 mg/kg. Kolaviron (100 mg/kg) was administered orally for 6 weeks (5 times weekly)...
2015: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/26130939/gastrointestinal-protective-efficacy-of-kolaviron-a-bi-flavonoid-from-garcinia-kola-following-a-single-administration-of-sodium-arsenite-in-rats-biochemical-and-histopathological-studies
#19
Akinleye S Akinrinde, Ebunoluwa Olowu, Ademola A Oyagbemi, Olutayo T Omobowale
BACKGROUND: Arsenic intoxication is known to produce symptoms including diarrhea and vomiting, which are indications of gastrointestinal dysfunction. OBJECTIVE: We investigated whether Kolaviron (KV) administration protected against sodium arsenite (NaAsO2)-induced damage to gastric and intestinal epithelium in rats. MATERIALS AND METHODS: Control rats (Group I) were given a daily oral dose of corn oil. Rats in other groups were given a single dose of NaAsO2 (100 mg/kg; intraperitoneal) alone (Group II) or after pretreatment for 7 days with KV at 100 mg/kg (Group III) and 200 mg/kg (Group IV)...
July 2015: Pharmacognosy Research
https://www.readbyqxmd.com/read/26129936/protective-activity-of-biflavanones-from-garcinia-kola-against-plasmodium-infection
#20
Benetode Konziase
ETHNOPHARMACOLOGICAL RELEVANCE: Garcinia kola is a medicinal plant traditionally used for malaria therapy in Central Africa. AIM OF THE STUDY: To evaluate the antimalarial potencies in vitro and in vivo of pure biflavanones from G. kola. MATERIALS AND METHODS: The pure biflavanones were obtained by bioassay-guided fractionation of a 70% ethanol extract of G. kola seeds and their chemical structures were elucidated by comparison of their NMR ((1)H and (13)C) and mass spectral data with those provided in the literature...
August 22, 2015: Journal of Ethnopharmacology
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