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Josephina G Kuiper, Irene D Bezemer, Maurice T Driessen, Averyan Vasylyev, Claus G Roehrborn, Fernie J A Penning-van Beest, Ron M C Herings
BACKGROUND: Previous studies have suggested a greater benefit for various outcomes in men diagnosed with benign prostatic hyperplasia (BPH) who are treated with dutasteride than for men treated with finasteride. This study investigates whether the rates of BPH-related prostate surgery and acute urinary retention (AUR) differ between dutasteride and finasteride users in the Netherlands. METHODS: From the PHARMO Database Network, men aged ≥50 years with a dispensing of dutasteride or finasteride with or without concomitant alpha-blocker treatment between March 1, 2003 and December 31, 2011 were selected...
2016: BMC Urology
Vincenzo Favilla, Giorgio Ivan Russo, Salvatore Privitera, Tommaso Castelli, Raimondo Giardina, Aldo E Calogero, Rosita A Condorelli, Sandro La Vignera, Sebastiano Cimino, Giuseppe Morgia
Lower urinary tract symptoms (LUTS) secondary to benign prostatic obstruction (BPO) represent one of the most common clinical complaints in adult men. Several drugs used for LUTS/BPO may strongly affect sexual function and bother. The aim of this systematic review and meta-analysis was to evaluate the impact of combination therapy with alpha-blockers (AB), 5-alpha reductase inhibitors (5-ARI) on the risk of erectile dysfunction(ED) and libido alterations (LA) from randomized clinical trial (RCT). Based on the inclusion and exclusion criteria, five RCTs involving 6131 patients were included in the analysis...
June 16, 2016: Aging Male: the Official Journal of the International Society for the Study of the Aging Male
Zachary Hamilton, J Kellogg Parsons
Prevention is an important treatment strategy for diminishing prostate cancer morbidity and mortality and is applicable to both early- and late-stage disease. There are three basic classifications of cancer prevention: primary (prevention of incident disease), secondary (identification and treatment of preclinical disease), and tertiary (prevention of progression or recurrence). Based on level I evidence, 5-alpha reductase inhibitors (5-ARIs) should be considered in selected men to prevent incident prostate cancer...
April 2016: Current Urology Reports
J Quentin Clemens, Howard B Goldman, Kelly H Zou, Xuemei Luo, David Russell, Douglass S Chapman, Canan B Esinduy, Jennifer T Anger
PURPOSE: We examined diagnostic tests and treatment patterns in men with new onset benign prostatic hyperplasia using consolidated national electronic health record data. MATERIALS AND METHODS: The Humedica® electronic health record database consists of de-identified patient records from approximately 25 million patients in the United States. Using this database, men with a new benign prostatic hyperplasia diagnosis (benign prostatic hyperplasia, bladder neck obstruction, urinary retention and incomplete bladder emptying) between July 1, 2009 and June 30, 2012 were included in study...
July 2016: Journal of Urology
Teemu J Murtola, Elina K Karppa, Kimmo Taari, Kirsi Talala, Teuvo L J Tammela, Anssi Auvinen
Randomized clinical trials have shown that use of 5α-reductase inhibitors (5-ARIs) lowers overall prostate cancer (PCa) risk compared to placebo, while the proportion of Gleason 8-10 tumors is elevated. It is unknown whether this affects PCa-specific survival. We studied disease-specific survival by 5-ARI usage in a cohort of 6,537 prostate cancer cases diagnosed in the Finnish Prostate Cancer Screening Trial and linked to the national prescription database for information on medication use. Cox proportional hazards regression was used to estimate hazard ratios and 95% confidence intervals for prostate cancer-specific deaths...
June 15, 2016: International Journal of Cancer. Journal International du Cancer
Furio Pirozzi Farina, Antonella Pischedda
Treatment-induced sexual dysfunctions (SD) are a recurrent and controversial topic in recent literature on the adverse events related to the use of 5-alpha-reductase inhibitors (5ARIs) (1, 2). In order to deal adequately with the various aspects of this topic, it is necessary to first cover some of the steps that allow a better definition and understanding of the subject.
December 2015: Archivio Italiano di Urologia, Andrologia
A La Torre, G Giupponi, D Duffy, A Conca, T Cai, A Scardigli
UNLABELLED: Sexual dysfunction is a potential side effect of BPH (benign prostatic hyperplasia) and LUTS (lower urinary tract symptoms) drugs: this article is a critical review of the current literature. Many studies have been published on this topic. Methodological flaws limit the conclusions of these studies, mainly because of the lack of diagnostic criteria for ejaculatory and sexual desire dysfunction. Few of these studies are RCTs. The α-blocker (also called α1-adrenergic antagonist, alpha-adrenoceptor antagonist, alpha-blocker or AB) and 5-ARI (also called 5α-reductase inhibitor or testosterone-5-alpha reductase inhibitor) drugs can in particular cause erectile dysfunction, ejaculatory disorders and reduction of sexual desire...
January 2016: Pharmacopsychiatry
David Robinson, Hans Garmo, Pär Stattin, Karl Michaëlsson
BACKGROUND: Lower urinary tract symptoms are common among older men and 5-α reductase inhibitors (5-ARI) are a group of drugs recommended in treating these symptoms. The effect on prostate volume is mediated by a reduction in dihydrotestosterone; however, this reduction is counterbalanced by a 25% rise in serum testosterone levels. Therefore, 5-ARI use might have systemic effects and differentially affect bone mineral density, muscular mass and strength, as well as falls, all of which are major determinants of fractures in older men...
2015: PloS One
Johann Fontana, Holger Wenz, Kirsten Schmieder, Martin Barth
BACKGROUND: This study was designed to evaluate the potential of the dynamic autoregulation index (ARI) to serve as an early warning system for an imminent clinical deterioration after subarachnoid hemorrhage (SAH). METHODS: All patients received a baseline digital subtraction angiography and a computed tomography (CT) prior to treatment. The clinical status, the ARI, and the transcranial Doppler (TCD) values were evaluated daily until discharge from the intensive care unit (ICU)...
May 2016: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
Gisele Lima Bezerra, Carlos Rocha Gomes Torres, Mateus Rodrigues Tonetto, Alvaro Henrique Borges, Milton Carlos Kuga, Matheus Coelho Bandeca, Leily Macedo Firoozmand
The objective of this study is to assess, in vitro, the shear bond strength of orthodontic brackets fixed with remineralizing adhesive systems submitted to thermomechanical cycling, simulating one year of orthodontic treatment. Sixty-four bovine incisor teeth were randomly divided into 4 experimental groups (n = 16): XT: Transbond XT, QC: Quick Cure, OL: Ortholite Color, and SEP: Transbond Plus Self-Etching Primer. The samples were submitted to thermomechanical cycling simulating one year of orthodontic treatment...
2015: TheScientificWorldJournal
Seth A Strope, Joel Vetter, Sean Elliott, Gerald L Andriole, Margaret A Olsen
OBJECTIVE: To assess the impact of surgery for benign prostatic hyperplasia (BPH) on use of medication (5-alpha reductase inhibitors, alpha blockers, antispasmodics), we assessed preoperative and postoperative medication utilization among surgically treated men. PATIENTS AND METHODS: Using the Truven Health Analytics MarketScan Commercial Claims Database, we defined a cohort of men aged <65 years who had surgical therapy for BPH with either transurethral resection of the prostate (TURP) or laser procedures from 2007 through 2009...
December 2015: Urology
Kentaro Yamakawa, Pradeep S Rajendran, Tatsuo Takamiya, Daigo Yagishita, Eileen L So, Aman Mahajan, Kalyanam Shivkumar, Marmar Vaseghi
Vagal nerve stimulation (VNS) has been shown to have antiarrhythmic effects, but many of these benefits were demonstrated in the setting of vagal nerve decentralization. The purpose of this study was to evaluate the role of afferent fiber activation during VNS on efferent control of cardiac hemodynamic and electrophysiological parameters. In 37 pigs a 56-electrode sock was placed over the ventricles to record local activation recovery intervals (ARIs), a surrogate of action potential duration. In 12 of 37 animals atropine was given systemically...
November 2015: American Journal of Physiology. Heart and Circulatory Physiology
Ralph R Scholten, Fred K Lotgering, Maria T Hopman, Arie Van Dijk, Maureen Van de Vlugt, Mirian C H Janssen, Marc E A Spaanderman
Formerly preeclamptic women are at risk for cardiovascular disease. Low plasma volume may reflect latent hypertension and potentially links preeclampsia with chronic cardiovascular disease. We hypothesized that low plasma volume in normotensive formerly preeclamptic women predisposes to hypertension. We longitudinally studied n=104 formerly preeclamptic women in whom plasma volume was measured 3 to 30 months after the preeclamptic pregnancy. Cardiovascular variables were assessed at 2 points in time (3-30 months postpartum and 2-5 years thereafter)...
November 2015: Hypertension
Sara C Martinez, Mirnela Byku, Eric L Novak, Ari M Cedars, Pirooz Eghtesady, Philip A Ludbrook, Joseph J Billadello
OBJECTIVE: Obesity affects adults with congenital heart disease (CHD). The effect of an increased body mass index (BMI) with respect to morbidity and mortality has not been evaluated in adults with complex CHD. Our objective was to evaluate the effects of increased BMI on heart failure and mortality in univentricular patients who had undergone Fontan palliation. METHODS: A query of Fontan patients' first appointments at the Washington University Center for Adults with CHD between 2007 and 2014 yielded 79 patients...
January 2016: Congenital Heart Disease
Dilek Erdoğan Arı, Arzu Yıldırım Ar, Firdevs Karadoğan, Yetkin Özcabı, Ayşegül Koçoğlu, Fatih Kılıç, Fatma Nur Akgün
STUDY OBJECTIVE: To evaluate the effectiveness of 0.125% bupivacaine compared to 0.25% bupivacaine for ultrasound-guided transversus abdominis plane (TAP) block in patients undergoing open inguinal hernia repair. DESIGN: Randomized, double-blind study. SETTING: Educational and research hospital. PATIENTS: Forty adult patients of American Society of Anesthesiologists physical status I-III undergoing elective primary unilateral open inguinal hernia repair under spinal anesthesia...
February 2016: Journal of Clinical Anesthesia
Francilena Maria Campos Santos Dias, Célia Regina Maio Pinzan-Vercelino, Rudys Rodolfo de Jesus Tavares, Júlio de Araújo Gurgel, Fausto Silva Bramante, Melissa Nogueira Proença Fialho
OBJECTIVE: To compare shear bond strength of different direct bonding techniques of orthodontic brackets to acrylic resin surfaces. METHODS: The sample comprised 64 discs of chemically activated acrylic resin (CAAR) randomly divided into four groups: discs in group 1 were bonded by means of light-cured composite resin (conventional adhesive); discs in group 2 had surfaces roughened with a diamond bur followed by conventional direct bonding by means of light-cured composite resin; discs in group 3 were bonded by means of CAAR (alternative adhesive); and discs in group 4 had surfaces roughened with a diamond bur followed by direct bonding by means of CAAR...
July 2015: Dental Press Journal of Orthodontics
Suvi T Vaara, Ilkka Parviainen, Ville Pettilä, Sara Nisula, Outi Inkinen, Ari Uusaro
Urine output (UO) criterion may increase the sensitivity of the definition of acute kidney injury (AKI). We determined whether the empirically derived definition for oliguria (<0.5 ml/kg/h) is independently associated with adverse outcome. Data analysis included hourly recorded UO from the prospective, multicenter FINNAKI study conducted in 16 Finnish intensive care units. Confounder-adjusted association of oliguria of different severity and duration primarily with the development of AKI defined by creatinine criterion (Cr-AKI) or renal replacement therapy (RRT) was assessed...
September 9, 2015: Kidney International
Beata Mickiewicz, Graham C Thompson, Jaime Blackwood, Craig N Jenne, Brent W Winston, Hans J Vogel, Ari R Joffe
INTRODUCTION: The first steps in goal-directed therapy for sepsis are early diagnosis followed by appropriate triage. These steps are usually left to the physician's judgment, as there is no accepted biomarker available. We aimed to determine biomarker phenotypes that differentiate children with sepsis who require intensive care from those who do not. METHODS: We conducted a prospective, observational nested cohort study at two pediatric intensive care units (PICUs) and one pediatric emergency department (ED)...
2015: Critical Care: the Official Journal of the Critical Care Forum
Elizabeth Aries
Rose Richardson Olver, devoted her professional life to understanding cognitive development, sex, and gender and to nurturing the development of 5 decades of students. She died on November 19, 2014, at age 77 in Amherst, Massachusetts, after a 3-year battle with cancer. Rose was born outside of Philadelphia, Pennsylvania, on January 17, 1937, daughter of Claude and Anne Richardson. Rose is survived by her husband, John, former U.S. Congressman for 21 years; her daughter, Martha Jane Olver; her brother, David Richardson, and sister-in-law, Jane Shelby Richardson; and by eight nieces and nephews...
September 2015: American Psychologist
Xia Wang, Qiuqiang Gao, Jie Bao
BACKGROUND: Furfural and 5-hydroxymethylfurfural (HMF) are the two major inhibitor compounds generated from lignocellulose pretreatment, especially for dilute acid, steam explosion, neutral hot water pretreatment methods. The two inhibitors severely inhibit the cell growth and metabolism of fermenting strains in the consequent bioconversion step. The biodetoxification strain Amorphotheca resinae ZN1 has demonstrated its extraordinary capacity of fast and complete degradation of furfural and HMF into corresponding alcohol and acid forms...
2015: Biotechnology for Biofuels
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