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https://www.readbyqxmd.com/read/28724772/binding-of-hsv-1-ul20-to-godz-affects-its-palmitoylation-and-is-essential-for-infectivity-and-proper-targeting-and-localization-of-ul20-and-gk
#1
Shaohui Wang, Kevin R Mott, Kolja Wawrowsky, Konstantin G Kousoulas, Bernhard Luscher, Homayon Ghiasi
HSV-1 UL20 plays a crucial role in the envelopment of the cytoplasmic virion and its egress. It is a non-glycosylated envelope protein that is regulated as a γ1 gene. Two-hybrid and pull-down assays demonstrated that UL20, but no other HSV-1 gene-encoded proteins, binds specifically to GODZ (a.k.a.: DHHC3), a cellular Golgi-specific Asp-His-His-Cys (DHHC) zinc finger protein. A catalytically inactive dominant-negative GODZ construct significantly reduced HSV-1 replication in vitro and affected the localization of UL20 and gK and their interactions but not gC...
July 19, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28722207/antihypertensive-drug-associated-angioedema-effect-modification-by-race-ethnicity
#2
Marsha E Reichman, Michael Wernecke, David J Graham, Jiemin Liao, John Yap, Yoganand Chillarige, Mary Ross Southworth, Stephine Keeton, Margie R Goulding, Katrina Mott, Jeffrey A Kelman
PURPOSE: Assess angioedema risk with exposure to angiotensin converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) compared with beta-blockers, by race/ethnicity. METHODS: New-user cohorts of Medicare beneficiaries 65 years or older initiating ACEI, ARB, or beta-blocker treatment from March 2007 to March 2014 were constructed. Angioedema incidence rates by drug and race/ethnicity were computed for 1-30 and 31-365 days of treatment. Cox proportional hazards regression was used to examine angioedema risk between cohorts...
July 19, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28715455/synthetic-melanin-bound-to-subunit-vaccine-antigens-significantly-enhances-cd8-t-cell-responses
#3
Antoine F Carpentier, Frédéric Geinguenaud, Thi Tran, Floraly Sejalon, Antoine Martin, Laurence Motte, Eric Tartour, Claire Banissi
Cytotoxic T-lymphocytes (CTLs) play a key role in immunity against cancer; however, the induction of CTL responses with currently available vaccines remains difficult. Because several reports have suggested that pigmentation and immunity might be functionally linked, we investigated whether melanin can act as an adjuvant in vaccines. Short synthetic peptides (8-35 amino acids long) containing T-cell epitopes were mixed with a solution of L-Dopa, a precursor of melanin. The mixture was then oxidized to generate nanoparticles of melanin-bound peptides...
2017: PloS One
https://www.readbyqxmd.com/read/28715033/synthesis-of-metastable-hard-magnetic-%C3%AE%C2%B5-fe2o3-nanoparticles-from-silica-coated-akaganeite-nanorods
#4
Marin Tadic, Irena Milosevic, Slavko Kralj, Miodrag Mitric, Darko Makovec, Marie-Louise Saboungi, Laurence Motte
We present a simple preparation route to obtain a nanoscale metastable hard-magnetic ε-Fe2O3 phase, using silica coated β-FeOOH nanorods as a precursor and an annealing process. The synthesized ε-Fe2O3 nanoparticles exhibit large coercivity (HC ∼ 20 kOe at 300 K and HC ∼ 1.6 kOe at 400 K), confirming their high potential for practical applications.
July 17, 2017: Nanoscale
https://www.readbyqxmd.com/read/28709494/multiple-abdominal-abscesses-a-not-so-common-presentation-of-ntm
#5
Darshan K Bajaj, R A S Kushwaha, Anand Srivastava, Mona Asnani
Non-tuberculous Mycobacteria/Mycobacterium other than tuberculosis (MOTT) are ubiquitous organisms. They are acid fast bacilli often giving trouble to the physician to distinguish it from Mycobacterium tuberculosis. These organisms are a menace for the treating physician as when to treat and when not to treat. They are often difficult to diagnose and may present in a variety of forms with propensity to cause number of infections of different body parts and organs. They are more common in immunocompromised individuals e...
July 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/28693110/potential-effects-of-brevetoxins-and-toxic-elements-on-various-health-variables-in-kemp-s-ridley-lepidochelys-kempii-and-green-chelonia-mydas-sea-turtles-after-a-red-tide-bloom-event
#6
Justin R Perrault, Nicole I Stacy, Andreas F Lehner, Cody R Mott, Sarah Hirsch, Jonathan C Gorham, John P Buchweitz, Michael J Bresette, Catherine J Walsh
Natural biotoxins and anthropogenic toxicants pose a significant risk to sea turtle health. Documented effects of contaminants include potential disease progression and adverse impacts on development, immune function, and survival in these imperiled species. The shallow seagrass habitats of Florida's northwest coast (Big Bend) serve as an important developmental habitat for Kemp's ridley (Lepidochelys kempii) and green (Chelonia mydas) sea turtles; however, few studies have been conducted in this area. Our objectives were (1) to evaluate plasma analytes (mass, minimum straight carapace length, body condition index [BCI], fibropapilloma tumor score, lysozyme, superoxide dismutase, reactive oxygen/nitrogen species, plasma protein electrophoresis, cholesterol, and total solids) in Kemp's ridleys and green turtles and their correlation to brevetoxins that were released from a red tide bloom event from July-October 2014 in the Gulf of Mexico near Florida's Big Bend, and (2) to analyze red blood cells in Kemp's ridleys and green turtles for toxic elements (arsenic, cadmium, lead, mercury, selenium, thallium) with correlation to the measured plasma analytes...
July 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28689529/multiple-mott-cells-in-periapical-lesion-of-the-oral-cavity
#7
Manika Arora, Karishma Desai, Deepa Mane
An entity of bizarre plasma cells has been observed, containing spherical inclusions of immunoglobulins within the cytoplasm. These cells are termed as Mott cells and are believed to occur commonly in cases of chronic inflammation. Until now, they were reported to occur in systemic diseases, various hematolymphoid malignancies and in some syndromes; but their occurrence in chronic periapical infections of the oral cavity, given the paucity of available literature, raises questions about their obscure nature...
June 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28686692/estimating-influenza-and-respiratory-syncytial-virus-associated-mortality-in-western-kenya-using-health-and-demographic-surveillance-system-data-2007-2013
#8
Gideon O Emukule, Peter Spreeuwenberg, Sandra S Chaves, Joshua A Mott, Stefano Tempia, Godfrey Bigogo, Bryan Nyawanda, Amek Nyaguara, Marc-Alain Widdowson, Koos van der Velden, John W Paget
BACKGROUND: Influenza and respiratory syncytial virus (RSV) associated mortality has not been well-established in tropical Africa. METHODS: We used the negative binomial regression method and the rate-difference method (i.e. deaths during low and high influenza/RSV activity months), to estimate excess mortality attributable to influenza and RSV using verbal autopsy data collected through a health and demographic surveillance system in Western Kenya, 2007-2013. Excess mortality rates were calculated for a) all-cause mortality, b) respiratory deaths (including pneumonia), c) HIV-related deaths, and d) pulmonary tuberculosis (TB) related deaths...
2017: PloS One
https://www.readbyqxmd.com/read/28683277/the-immunometabolism-choreography
#9
EDITORIAL
Nikla Emambokus, Anne Granger, Rosalind Mott, Taneli Helenius
No abstract text is available yet for this article.
July 5, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28680956/patient-reported-outcomes-pros-as-part-of-value-based-care-can-shape-therapy-guidelines-impact-on-emerging-targeted-agents-and-immunotherapy-protocols-in-resource-limited-regions
#10
EDITORIAL
Frank E Mott
Patient reported outcomes (PROs) are commonly integrated into clinical trials for new cancer therapies or treatment modalities; however, beyond a cursory review during the registration process for a new drug, these important measures of patient satisfaction and cost-effectiveness are often under-used in daily practice. We cite literature under-scoring the value of PROs not only in clinical trials, but in practical decision making and how such metrics can help guide the oncologist and the patient in choosing the best and most cost-effective therapy for their cancer...
2017: Oncology and Therapy
https://www.readbyqxmd.com/read/28680063/bi-2212-1t-tas2-van-der-waals-junctions-interplay-of-proximity-induced-high-t-c-superconductivity-and-cdw-order
#11
Ang J Li, Xiaochen Zhu, G R Stewart, Arthur F Hebard
Understanding the coexistence, competition and/or cooperation between superconductivity and charge density waves (CDWs) in the transition metal dichalcogenides (TMDs) is an elusive goal which, when realized, promises to reveal fundamental information on this important class of materials. Here, we use four-terminal current-voltage measurements to study the Van der Waals interface between freshly exfoliated flakes of the high-T c superconductor, Bi-2212, and the CDW-dominated TMD layered material, 1T-TaS2. For highly transparent barriers, there is a pronounced Andreev reflection feature providing evidence for proximity-induced high-T c superconductivity in 1T-TaS2 with a surprisingly large energy gap (~20 meV) equal to half that of intrinsic Bi-2212 (~40 meV)...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28676693/selective-breeding-and-selection-mapping-using-a-novel-wild-derived-heterogeneous-stock-of-mice-revealed-two-closely-linked-loci-for-tameness
#12
Yuki Matsumoto, Tatsuhiko Goto, Jo Nishino, Hirofumi Nakaoka, Akira Tanave, Toshiyuki Takano-Shimizu, Richard F Mott, Tsuyoshi Koide
Tameness is a major behavioral factor for domestication, and can be divided into two potential components: motivation to approach humans (active tameness) and reluctance to avoid humans (passive tameness). We identified genetic loci for active tameness through selective breeding, selection mapping, and association analysis. In previous work using laboratory and wild mouse strains, we found that laboratory strains were predominantly selected for passive tameness but not active tameness during their domestication...
July 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28668195/selected-abstracts-from-the-2017-spn-conference
#13
Sandy Mott
No abstract text is available yet for this article.
June 28, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28665669/nonequilibrium-gw-edmft-antiscreening-and-inverted-populations-from-nonlocal-correlations
#14
Denis Golež, Lewin Boehnke, Hugo U R Strand, Martin Eckstein, Philipp Werner
We study the dynamics of screening in photodoped Mott insulators with long-ranged interactions using a nonequilibrium implementation of the GW plus extended dynamical mean-field theory formalism. Our study demonstrates that the complex interplay of the injected carriers with bosonic degrees of freedom (charge fluctuations) can result in long-lived transient states with properties that are distinctly different from those of thermal equilibrium states. Systems with strong nonlocal interactions are found to exhibit a self-sustained population inversion of the doublons and holes...
June 16, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28662254/issues-influencing-success-comparing-the-perspectives-of-nurse-educators-and-diverse-nursing-students
#15
Bonnie L Fuller, Jennifer A Mott-Smith
BACKGROUND: Research has shown that diverse nursing students report experiencing numerous issues that affect their progression through nursing programs. At the same time, research has also shown that nurse educators find it challenging to meet the needs of these students. What is missing is an analysis of how these two perspectives intersect. METHOD: A mixed-methods parallel study compared the perceptions of diverse nursing students (n =13) and nurse educators (n = 22) regarding the learning environment in a baccalaureate nursing program...
July 1, 2017: Journal of Nursing Education
https://www.readbyqxmd.com/read/28661017/n-type-superconductivity-in-an-organic-mott-insulator-induced-by-light-driven-electron-doping
#16
Masayuki Suda, Naoto Takashina, Supawadee Namuangruk, Nawee Kungwan, Hidehiro Sakurai, Hiroshi M Yamamoto
The presence of interface dipoles in self-assembled monolayers (SAMs) gives rise to electric-field effects at the device interfaces. SAMs of spiropyran derivatives can be used as photoactive interface dipole layer in field-effect transistors because the photochromism of spiropyrans involves a large dipole moment switching. Recently, light-induced p-type superconductivity in an organic Mott insulator, κ-(BEDT-TTF)2 Cu[N(CN)2 ]Br (κ-Br: BEDT-TTF = bis(ethylenedithio)tetrathiafulvalene) has been realized, thanks to the hole carriers induced by significant interface dipole variation in the spiropyran-SAM...
June 29, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28653658/charge-ordering-and-magnetic-frustration-in-csfe2f6
#17
Shanshan Liu, Yuanhui Xu, Yanli Cui, Jing Wang, Keju Sun, Shengxue Yu, Xianfeng Hao
The structural, electronic and magnetic properties of a charge-ordered iron fluoride material CsFe(2+)Fe(3+)F6 have been explored by density functional theory calculations based on the generalized gradient approximation  +  U approach, which was implemented in the VASP code. The material exhibits a 3D pyrochlore-related structure which consists of corner-shared Fe(2+)F6 and Fe(3+)F6 octahedra. Our results confirm that CsFe2F6 is a Mott-Hubbard insulator, and bears a magnetically frustrated ground state in which the localized 3d electrons are antiferromagnetically coupled between the homogeneous Fe ions (Fe(3+)-Fe(3+) along the b axis, and Fe(2+)-Fe(2+) along the a axis), while interactions between the heterogeneous Fe ions (Fe(3+)-Fe(2+) along the c axis) are frustrated, consistent with Goodenough-Kanamori superexchange interactions...
August 9, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28650954/prevalence-of-sexual-dimorphism-in-mammalian-phenotypic-traits
#18
Natasha A Karp, Jeremy Mason, Arthur L Beaudet, Yoav Benjamini, Lynette Bower, Robert E Braun, Steve D M Brown, Elissa J Chesler, Mary E Dickinson, Ann M Flenniken, Helmut Fuchs, Martin Hrabe de Angelis, Xiang Gao, Shiying Guo, Simon Greenaway, Ruth Heller, Yann Herault, Monica J Justice, Natalja Kurbatova, Christopher J Lelliott, K C Kent Lloyd, Ann-Marie Mallon, Judith E Mank, Hiroshi Masuya, Colin McKerlie, Terrence F Meehan, Richard F Mott, Stephen A Murray, Helen Parkinson, Ramiro Ramirez-Solis, Luis Santos, John R Seavitt, Damian Smedley, Tania Sorg, Anneliese O Speak, Karen P Steel, Karen L Svenson, Shigeharu Wakana, David West, Sara Wells, Henrik Westerberg, Shay Yaacoby, Jacqueline K White
The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans.
June 26, 2017: Nature Communications
https://www.readbyqxmd.com/read/28644632/mott-transition-in-the-a15-phase-of-cs_-3-c_-60-absence-of-a-pseudogap-and-charge-order
#19
H Alloul, P Wzietek, T Mito, D Pontiroli, M Aramini, M Riccò, J P Itie, E Elkaim
We present a detailed NMR study of the insulator-to-metal transition induced by an applied pressure p in the A15 phase of Cs_{3}C_{60}. We evidence that the insulating antiferromagnetic (AFM) and superconducting (SC) phases coexist only in a narrow p range. At fixed p, in the metallic state above the SC transition T_{c}, the ^{133}Cs and ^{13}C NMR spin-lattice relaxation data are seemingly governed by a pseudogaplike feature. We prove that this feature, also seen in the ^{133}Cs NMR shift data, is rather a signature of the Mott transition which broadens and smears out progressively for increasing (p,T)...
June 9, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28644474/%C3%AF-electron-s%C3%A2-%C3%A2-%C3%A2-quantum-spin-liquid-state-in-an-ionic-polyaromatic-hydrocarbon
#20
Yasuhiro Takabayashi, Melita Menelaou, Hiroyuki Tamura, Nayuta Takemori, Takashi Koretsune, Aleš Štefančič, Gyöngyi Klupp, A Johan C Buurma, Yusuke Nomura, Ryotaro Arita, Denis Arčon, Matthew J Rosseinsky, Kosmas Prassides
Molecular solids with cooperative electronic properties based purely on π electrons from carbon atoms offer a fertile ground in the search for exotic states of matter, including unconventional superconductivity and quantum magnetism. The field was ignited by reports of high-temperature superconductivity in materials obtained by the reaction of alkali metals with polyaromatic hydrocarbons, such as phenanthrene and picene, but the composition and structure of any compound in this family remained unknown. Here we isolate the binary caesium salts of phenanthrene, Cs(C14H10) and Cs2(C14H10), to show that they are multiorbital strongly correlated Mott insulators...
July 2017: Nature Chemistry
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