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https://www.readbyqxmd.com/read/29752712/maternal-diabetes-alters-the-development-of-ductus-venosus-shunting-in-the-fetus
#1
Agnethe Lund, Cathrine Ebbing, Svein Rasmussen, Torvid W Kiserud, Jörg Kessler
INTRODUCTION: Despite adequate glycemic control, the risks of fetal macrosomia and perinatal complications are increased in diabetic pregnancies. Adjustments of the umbilical venous (UV) distribution, including increased ductus venosus (DV) shunting, can be important fetal compensatory mechanisms, but the impact of pregestational diabetes on UV and DV flow is not known. MATERIAL AND METHODS: In this prospective study, 49 women with pregestational diabetes mellitus underwent monthly ultrasound examinations from gestational week 20 to 36...
May 11, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29716434/effect-of-sildenafil-on-pulmonary-circulation-and-cardiovascular-function-in-near-term-fetal-sheep-during-hypoxemia
#2
Amarnath Bhide, Leena Alanne, Juha Rasanen, Heikki Huhta, Juulia Junno, Merja Kokki, Tiina Erkinaro, Pasi Ohtonen, Mervi Haapsamo, Ganesh Acharya
Sildenafil is a potential new treatment for placental insufficiency in human pregnancies as it reduces the breakdown of vasodilator nitric oxide. Pulmonary vasodilatation is observed in normoxemic fetuses following sildenafil administration. Placental insufficiency often leads to fetal hypoxemia that can cause pulmonary vasoconstriction and fetal cardiac dysfunction as evidenced by reduced isovolumic myocardial velocities. We tested the hypotheses that sildenafil, when given directly to the hypoxemic fetus, reverses reactive pulmonary vasoconstriction, increases left ventricular cardiac output by increasing pulmonary venous return, and ameliorates hypoxemic myocardial dysfunction...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29707375/transcatheter-closure-of-a-large-patent-ductus-arteriosus-using-jugular-access-in-an-infant
#3
Precylia Fernandes, Anass Assaidi, Alban-Elouen Baruteau, Alain Fraisse
Trans-catheter device closure of patent ductus arteriosus (PDA) via femoral route is the commonly used, safe and effective procedure. Trans-jugular approach has been successfully used in older children with interrupted inferior vena cava. We report a case of successful occlusion of PDA using Amplatzer duct occluder (ADO) via trans-jugular approach following difficulties encountered in gaining femoral venous access. A 6-month-old male infant, weighing 8 kg was admitted for percutaneous catheter closure of PDA...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29599384/pneumatosis-intestinalis-in-a-preterm-infant-should-we-treat-all-intestinal-pneumatosis-as-necrotising-enterocolitis
#4
Siu Jun Chew, Rajadurai Samuel Victor, Krishna Revanna Gopagondanahalli, Suresh Chandran
Gastric pneumatosisis a very rare site of pneumatosis intestinalis (PI), and we report this finding in a preterm female infant with cyanotic congenital heart disease. The infant was stable initially on nasal intermittent mandatory ventilation; however, torrential pulmonary flow through a large patent ductus arteriosus prompted closure using oral ibuprofen. After an episode of haematochezia, she developed PI, affecting mainly the gastric wall and small intestine with portal venous gas. Her bowel movements were regular, with no abdominal distension or significant gastric aspirates...
March 28, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29540889/transcatheter-closure-of-patent-ductus-arteriosus-through-only-venous-route
#5
Abdul Malik Sheikh, Abdul Karim Duke, Hina Sattar
Patent ductus arteriosus is a common congenital cardiac defect comprising 5-10% of all these defects in term neonates. Although open chest and video-assisted interruption are still in use, transcatheter occlusion has rapidly become the first choice for patent ductus arteriosus closure in the appropriate patient. Percutaneous closure of patent ductus arteriosus is widely done by transvenous approach guided by aortic access. We present the case of a 2 year old girl who underwent patent ductus arteriosus device occlusion with transvenous access only...
March 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/29511867/endovascular-treatment-of-congenital-arterioportal-fistulas
#6
Gulraiz Chaudry, Anna P Lillis, Raja Shaikh, Horacio M Padua, Rush H Chewning, Ahmad I Alomari
PURPOSE: To characterize anatomy of congenital arterioportal fistulas (CAPF) and correlate this with technique and outcomes of transcatheter embolization (TCE). MATERIALS AND METHODS: Retrospective review was conducted of children with CAPF that underwent TCE in a 10-year period. Medical records, imaging and procedure details were reviewed. TCE was performed via transarterial (n = 5), portal (n = 5) or patent ductus venosus (n = 1) approach. Embolic agents used were coils (n = 10), Onyx (n = 1) and Amplatzer septal occluder (n = 1)...
March 6, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29161235/influence-of-ductus-arteriosus-on-peripheral-muscle-oxygenation-and-perfusion-in-neonates
#7
Lukas P Mileder, Tessa Müller, Nariae Baik-Schneditz, Jasmin Pansy, Bernhard Schwaberger, Corinna Binder-Heschl, Berndt Urlesberger, Gerhard Pichler
OBJECTIVE: In neonates, a patent ductus arteriosus (DA) may be associated with severe complications. We used near-infrared spectroscopy (NIRS) with venous occlusion to investigate the influence of an open DA on peripheral muscle oxygenation/perfusion in preterm neonates. APPROACH: We analyzed secondary outcome parameters collected as part of prospective observational studies. NIRS measurements were performed between the first and third day of life. Arterial oxygen saturation (SaO2 ) and heart rate (HR) were monitored by pulse oximetry on the ipsilateral foot...
December 28, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/29146864/acute-hypoxia-reoxygenation-and-vascular-oxygen-sensing-in-the-chicken-embryo
#8
Riazuddin Mohammed, Carlos E Salinas, Dino A Giussani, Carlos E Blanco, Angel L Cogolludo, Eduardo Villamor
Fetal/perinatal hypoxia is one of the most common causes of perinatal morbidity and mortality and is frequently accompannied by vascular dysfunction. However, the mechanisms involved have not been fully delineated. We hypothesized that exposure to acute hypoxia-reoxygenation induces alterations in vascular O2 sensing/signaling as well as in endothelial function in the chicken embryo pulmonary artery (PA), mesenteric artery (MA), femoral artery (FA), and ductus arteriosus (DA). Noninternally pipped 19-day embryos were exposed to 10% O2 for 30 min followed by reoxygenation with 21% O2 or 80% O2 Another group was constantly maintained at 21% O2 or at 21% O2 for 30 min and then exposed to 80% O2 Following treatment, responses of isolated blood vessels to hypoxia as well as endothelium-dependent (acetylcholine) and -independent (sodium nitroprusside and forskolin) relaxation were investigated in a wire myograph...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/29125447/multiple-echocardiography-abnormalities-associated-with-endoscopic-third-ventriculostomy-failure
#9
Ashish H Shah, George M Ibrahim, Jun Sasaki, John Ragheb, Sanjiv Bhatia, Toba N Niazi
OBJECTIVE Although endoscopic third ventriculostomy (ETV) with choroid plexus cauterization (CPC) has gained increasing prominence in the management of hydrocephalus caused by intraventricular hemorrhage of prematurity, the rates of long-term shunt independence remain low. Furthermore, limited evidence is available to identify infants who might benefit from the procedure. The authors tested the hypothesis that elevated venous pressure that results from comorbid cardiac disease might predispose patients to ETV/CPC failure and shunt dependence...
January 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29094424/fetal-sheep-central-haemodynamics-and-cardiac-function-during-occlusion-of-the-ascending-aorta
#10
Heikki Huhta, Juulia Junno, Mervi Haapsamo, Tiina Erkinaro, Pasi Ohtonen, Lowell E Davis, A Roger Hohimer, Ganesh Acharya, Juha Rasanen
What is the central question of this study? The fetal aortic isthmus has an important physiological role, allowing communication between the left and right ventricular outputs, which are arranged in parallel. Can the aortic isthmus provide unrestrictive communication between the left and right ventricular circulations during occlusion of the ascending aorta? What is the main finding and its importance? During occlusion of the ascending aorta, fetal carotid artery perfusion pressure fell significantly, showing that the aortic isthmus failed to redirect blood flow and pressure from the ductus arteriosus to the aortic arch...
January 1, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29072164/effects-of-a-lipid-emulsion-containing-fish-oil-on-polyunsaturated-fatty-acid-profiles-growth-and-morbidities-in-extremely-premature-infants-a-randomized-controlled-trial
#11
Svetlana Najm, Chatarina Löfqvist, Gunnel Hellgren, Eva Engström, Pia Lundgren, Anna-Lena Hård, Alexandre Lapillonne, Karin Sävman, Anders K Nilsson, Mats X Andersson, Lois E H Smith, Ann Hellström
BACKGROUND & AIMS: The purpose of the study was to compare the effects of the parenteral emulsion SMOFlipid® , with 15% fish oil, with Clinoleic® on retinopathy of prematurity (ROP) and other morbidities and growth, and to compare their impact on longitudinal serum levels of fatty acids. Retinopathy of prematurity, other morbidity and growth were correlated with each parenteral lipid supplement. METHODS: Ninety infants born at gestational age <28 weeks were randomized to treatment with SMOFlipid® or Clinoleic® ...
August 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29066474/transcatheter-occlusion-of-the-patent-ductus-arteriosus-in-premature-infants-weighing-less-than-1200-g
#12
Patrice Morville, Stephanie Douchin, Helene Bouvaist, Claire Dauphin
OBJECTIVES: Over the last few decades different strategies have been proposed to treat persistent ductal patency in premature infants. The advent of the Amplatzer Duct Occluder II Additional Size (ADOIIAS) provided the potential to close the patent ductus arteriosus (PDA). Opinions differ on the significance and treatment of PDA in premature neonates. Because surgical ligation and medical therapy both have their drawbacks, interventional catheterisation can be considered as an alternative means of closing the ductus arteriosus...
May 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29057136/prenatal-and-postnatal-sonographic-confirmation-of-congenital-absence-of-the-ductus-venosus-in-a-child-with-noonan-syndrome
#13
Christopher L Newman, Matthew R Wanner, Brandon P Brown
The ductus venosus serves as an important vascular pathway for intrauterine circulation. This case presents a description of an absent ductus venosus in a female patient with Noonan syndrome, including both prenatal and postnatal imaging of the anomaly. In the setting of the anomalous vascular connection, the umbilical vein courses inferiorly to the iliac vein in parallel configuration with the umbilical artery. This finding was suspected based on prenatal imaging and the case was brought to attention when placement of an umbilical catheter was thought to be malpositioned given its appearance on radiography...
2017: Case Reports in Radiology
https://www.readbyqxmd.com/read/29044713/investigation-of-umbilical-venous-vessels-anatomy-and-diameters-as-a-guideline-for-catheter-placement-in-newborns
#14
F Eifinger, Z Fuchs, F Koerber, T Persigehl, M Scaal
Umbilical cord catheters (UCC) are important for the primary care of critically ill newborns. To analyze anatomical variations of the umbilical vein (UV) and its further course, we performed abdominal spiral-CT examinations on stillborns. The aim of the study was to explore the high incidence of mal-positioned UCCs and to improve their positioning. Eighteen stillborns were investigated (29.2 weeks ± 6.7 weeks (IQR)). CTs were performed using either air or contrast medium injection into the UV. We measured the diameter at the narrowest points of (i) the umbilical vein, (ii) the segmental portal vein, (iii) the left portal vein, (iv) the umbilical recess, and (v) the ductus venosus...
March 2018: Clinical Anatomy
https://www.readbyqxmd.com/read/28934814/prenatal-diagnosis-of-agenesis-of-ductus-venosus-a-retrospective-study-of-anatomic-variants-associated-anomalies-and-impact-on-postnatal-outcome
#15
Brigitte Strizek, Aikaterini Zamprakou, Ingo Gottschalk, Maria Roethlisberger, Astrid Hellmund, Andreas Müller, Ulrich Gembruch, Annegret Geipel, Christoph Berg
Purpose To assess the anatomic variants, associated anomalies and postnatal outcome of fetuses with a prenatally diagnosed agenesis of ductus venosus (ADV). Materials and Methods Retrospective study of 119 cases with agenesis of ductus venosus diagnosed by prenatal ultrasound in two tertiary referral centers from 2006 to 2014. The type and location of the umbilical venous drainage site was noted. Charts were reviewed for associated structural or chromosomal anomalies, pregnancy outcome and postnatal course...
September 21, 2017: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/28879526/intracardiac-echocardiography-for-structural-heart-and-electrophysiological-interventions
#16
REVIEW
Craig Basman, Yuvrajsinh J Parmar, Itzhak Kronzon
PURPOSE OF REVIEW: With an increasing number of interventional procedures performed for structural heart disease and cardiac arrhythmias each year, echocardiographic guidance is necessary for safe and efficient results. The purpose of this review article is to overview the principles of intracardiac echocardiography (ICE) and describes the peri-interventional role of ICE in a variety of structural heart disease and electrophysiological interventions. RECENT FINDINGS: Both transthoracic (TTE) and transesophageal echocardiography have limitations...
September 6, 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28691263/stenting-the-vertical-ductus-arteriosus-via-axillary-artery-access-using-wire-target-technique
#17
Tugcin Bora Polat
OBJECTIVES: To retrospectively review the outcome of stent placement in neonates with a vertical ductus, present a technique of ductal stenting via the axillary artery and compare it to ductal stening via the femoral venous access. DESIGN: Nineteen patients with duct-dependent pulmonary circulations through a vertical ductus arteriosus were treated with stent implantation. Those patients were retrospectively included in the study. In the first nine of these cases, stent delivery was done transvenously...
December 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/28658134/treprostinil-for-persistent-pulmonary-hypertension-of-the-newborn-with-early-onset-sepsis-in-preterm-infant-2-case-reports
#18
Bo Young Park, Sung-Hoon Chung
RATIONALE: Persistent pulmonary hypertension of the newborn (PPHN) is a syndrome of failed circulatory adaptation at birth with persisting increased pulmonary vascular resistance that is associated with high mortality rates especially in preterm infants. PATIENT CONCERNS: We reported 2 cases of PPHN in preterm infants with respiratory distress syndrome and early onset sepsis refractory to therapy with vasopressors, inotropes, and inhaled nitric oxide (iNO), in whom treatment with treprostinil was successful...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28629280/absent-ductus-venosus-case-series-from-two-tertiary-centres
#19
Giuseppe Maria Maruotti, Gabriele Saccone, Andrea Ciardulli, Laura Letizia Mazzarelli, Vincenzo Berghella, Pasquale Martinelli
INTRODUCTION: Congenital absence of the ductus venosus (ADV) is a rare vascular anomaly often associated with fetal cardiac and extracardiac anomalies, aneuploidies, and hydrops. The prognosis depends on the patterns of abnormal venous circulation, on the associated malformations and on chromosomal aberrations. METHODS: We performed a retrospective audit of all consecutive cases with ADV referred in our centres and analysed the outcomes. RESULTS: A total of six cases with prenatally diagnosed ADV were identified...
July 12, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28471089/transcatheter-closure-of-hemodynamic-significant-patent-ductus-arteriosus-in-32-premature-infants-by-amplatzer-ductal-occluder-additional-size-adoiias
#20
Patrice Morville, Ahmad Akhavi
OBJECTIVES: The advent of Amplatzer Duct Occluder II additional Size (ADOIIAS) provided the potential to close hemodynamic significant patent ductus arteriosus (HSPDA) and to analyze the feasibility, safety and efficacy of the device. BACKGROUND: Treatment of a patent ductus arteriosus (PDA) in very premature neonates is still a dilemma for the neonatalogist who has to consider its significance and has to choose among different treatment options. Because surgical ligation and medical therapy both have their drawbacks, interventional catheterization might provide an alternative means of closing HSPDA...
May 4, 2017: Catheterization and Cardiovascular Interventions
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