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ocular cicatricial pemphigoid

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https://www.readbyqxmd.com/read/28988898/elevated-aqueous-cytokine-levels-in-eyes-with-ocular-surface-diseases
#1
Naohiko Aketa, Takefumi Yamaguchi, Teru Asato, Yukari Yagi-Yaguchi, Terumasa Suzuki, Kazunari Higa, Toshihide Kurihara, Yoshiyuki Satake, Kazuo Tsubota, Jun Shimazaki
PURPOSE: To evaluate cytokine and protein levels in the aqueous humor (AqH) of eyes with ocular surface diseases. DESIGN: Prospective consecutive case series. METHODS: This study includes 14 patients (62.4±13.7 years old) with chronic-phase ocular surface diseases (4 with ocular cicatricial pemphigoid, 5 with chemical burns, 2 with a thermal burn, 2 with Stevens-Johnson syndrome, and 1 with exposure keratitis), 14 matched patients without ocular surface disease (controls with corneal scar) and 30 patients who underwent cataract surgery (healthy controls)...
October 5, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28922328/minor-salivary-gland-transplantation-for-severe-dry-eyes
#2
Tais Hitomi Wakamatsu, Ana Estela Besteti Pires Ponce SantʼAnna, Priscila Cardoso Cristovam, Venâncio Avancini Ferreira Alves, Alda Wakamatsu, José Alvaro Pereira Gomes
Dry eye is a multifactorial disease comprising a wide spectrum of ocular surface alterations and symptoms of discomfort. In most patients with aqueous-deficient dry eye, pharmaceutical tear substitutes are used to control symptoms and prevent ocular surface damage. However, in severe dry eye conditions caused by cicatricial disorders, such as Stevens-Johnson syndrome and ocular cicatricial mucous membrane pemphigoid, noninvasive treatments are insufficient, and patients are at risk of developing complications that can lead to blindness...
November 2017: Cornea
https://www.readbyqxmd.com/read/28509683/conjunctival-squamous-cell-neoplasia-associated-with-ocular-cicatricial-pemphigoid
#3
Catherine J Choi, Frederick A Jakobiec, Fouad R Zakka, C Stephen Foster, James Chodosh, Suzanne K Freitag
The purpose of this study was to describe a possible causal relationship between ocular cicatricial pemphigoid (OCP) and ocular surface squamous neoplasia. Two middle-aged female patients with already diagnosed OCP were studied in regard to the subsequent onset of conjunctival squamous neoplasia. Their clinical histories, ocular examinations, clinical photographs, and results of biopsies and any ancillary immunofluorescent laboratory evaluation studies were carefully reviewed. One patient had a preinvasive squamous dysplasia and the other an invasive squamous cell carcinoma, both in the unequivocal setting of OCP with bilateral conjunctivitis, symblephara, and forniceal foreshortening...
May 15, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28154932/rituximab-in-the-treatment-of-ocular-cicatricial-pemphigoid-a-retrospective-cohort-study
#4
Caiyun You, Neerav Lamba, Andres F Lasave, Lina Ma, Mikhail Hernandez Diaz, C Stephen Foster
PURPOSE: The purpose was to evaluate the effectiveness and safety of rituximab (RTX) for the treatment of patients with aggressive ocular cicatricial pemphigoid (OCP). METHODS: A review of patient records at a tertiary referral center with biopsy confirmed OCP who presented between 2006 and 2016. Sixty-one eyes of 32 patients with symptomatic OCP who received treatment with RTX monotherapy or RTX in combination with additional immunomodulatory treatment (IMT) were evaluated...
June 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28079687/periocular-amyloidosis-manifesting-as-pseudopemphigoid-treated-with-mitomycin-c
#5
Kaveh Vahdani, Vladimir T Thaller, Giorgio Albanese, Andrew F Dean
PURPOSE: To describe an unusual cicatrizing manifestation of periocular amyloid and the utility of adjuvant antimetabolite therapy. METHODS: This is a case report of a 49-year old woman with progressive bilateral upper lid ptosis, who was found to have bilateral inferior forniceal masses with thickening of the conjunctiva. Conjunctival and eyelid biopsies showed evidence of amyloid deposition. Systemic evaluation did not reveal any evidence of systemic amyloidosis...
April 2017: Cornea
https://www.readbyqxmd.com/read/28079656/endoscopic-cyclophotocoagulation-for-the-treatment-of-glaucoma-in-boston-keratoprosthesis-type-ii-patient
#6
Linda Yi-Chieh Poon, James Chodosh, Demetrios G Vavvas, Claes H Dohlman, Teresa C Chen
We describe the surgical technique of endoscopic cyclophotocoagulation in a Boston keratoprosthesis type II patient. This patient with ocular cicatricial pemphigoid had pars plana endoscopic cyclophotocoagula through wounds created in the eyelids.
April 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/27904583/the-role-of-intravenous-immunoglobulin-in-treatment-of-mucous-membrane-pemphigoid-a-review-of-literature
#7
REVIEW
Soheil Tavakolpour
BACKGROUND: Mucous membrane pemphigoid (MMP) is considered an autoimmune blistering disease that predominantly affects mucous membranes. Various treatments are available for controlling the diseases, but not all of them may respond. MATERIALS AND METHODS: PubMed and Google Scholar were searched for all the associated studies until 2015, using the keywords such as "cicatricial pemphigoid" or "ocular pemphigoid" or "mucous membrane pemphigoid" or "MMP" and "intravenous immunoglobulin" or "IVIg" to find all the relevant studies...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27661067/combined-use-of-rituximab-and-intravenous-immunoglobulin-for-severe-autoimmune-cicatricial-conjunctivitis-an-interventional-case-series
#8
Bernhard Steger, Savitha Madhusudan, Stephen B Kaye, Amira Stylianides, Vito Romano, Sundas E Maqsood, Janice Harper, Sajjad Ahmad
PURPOSE: Despite the availability of systemic immunosuppressants, cicatricial conjunctivitis (CC) remains a potentially blinding ocular surface disease. We aim to describe the combined use of rituximab (RTX) and intravenous immunoglobulin (IVIg) for severe recalcitrant autoimmune CC. METHODS: In this single-center retrospective interventional case series with follow-up between 32 and 65 months, 3 cases with mucous membrane pemphigoid (patients 1-3) and 1 case with linear IgA disease (patient 4) were included...
December 2016: Cornea
https://www.readbyqxmd.com/read/27631412/-involvement-of-mucous-membranes-in-autoimmune-bullous-diseases
#9
REVIEW
C Günther
Autoimmune bullous diseases are characterized by intraepidermal or subepidermal autoantibody deposition that leads to blisters and secondary erosion. Mucous membranes are frequently affected in pemphigus vulgaris and always involved in cicatricial and mucosal pemphigoid. Mucosal lesions are detected less frequently in patients with bullous pemphigoid or epidermolysis bullosa acquisita. The diagnosis of autoimmune bullous disorders is based on determination of the subtype of autoantibodies bound in the skin and the clinical picture...
October 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/27275431/clinical-features-and-in-vivo-confocal-microscopy-assessment-in-12-patients-with-ocular-cicatricial-pemphigoid
#10
Qin Long, Ya-Gang Zuo, Xue Yang, Ting-Ting Gao, Jie Liu, Ying Li
AIM: To describe the clinical features and microstructural characteristics assessed by in vivo confocal microscopy (IVCM) in patients with ocular cicatricial pemphigoid (OCP). METHODS: A descriptive, uncontrolled case series study. Patients diagnosed with OCP were examined by clinical history, slit-lamp biomicroscopy features and IVCM images. The results of direct immunofluorescence (DIF) biopsies and indirect immunofluorescence (IIF) were also recorded. Local and systemic immunosuppressive therapy were administered and adjusted according to response...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27041284/-ocular-cicatricial-pemphigoid-a-retrospective-study
#11
E Szabó, M Palos, P Skalická
INTRODUCTION: Ocular cicatricial pemphigoid (OCP) is rare, severe, sight threatening autoimmune disease of the conjunctiva, which affects elderly patients, more often women. AIM: To evaluate the success rate of stabilisation of ocular findings in patients with OCP. METHODS: Retrospective study of patients from Centre of Conjunctival and Corneal Diseases at Department of Ophthalmology, General University Hospital and 1st Medical Faculty of Charles University in Prague in 1992-2013 was performed...
February 2016: Ceská a Slovenská Oftalmologie
https://www.readbyqxmd.com/read/26903186/autoimmune-bullous-diseases-with-skin-and-eye-involvement-cicatricial-pemphigoid-pemphigus-vulgaris-and-pemphigus-paraneoplastica
#12
REVIEW
Karen C Broussard, Theresa G Leung, Ahmadreza Moradi, Jennifer E Thorne, Jo-David Fine
Autoimmune blistering diseases are a heterogeneous group of disorders that mostly affect the skin and mucous membranes. Occasionally, other organ systems may be involved, depending on the unique pathophysiology of each disease. Cicatricial pemphigoid, pemphigus vulgaris, and paraneoplastic pemphigus are distinct entities, but all have the potential to have cutaneous and ocular involvement. Awareness and early recognition of ocular involvement in these diseases is important given the increased risk for vision loss and blindness with delay in management...
March 2016: Clinics in Dermatology
https://www.readbyqxmd.com/read/26708362/update-on-ocular-cicatricial-pemphigoid-and-emerging-treatments
#13
REVIEW
Munther M Queisi, Mike Zein, Neerav Lamba, Halea Meese, Charles Stephen Foster
Mucous membrane pemphigoid is a systemic disorder that primarily affects mucous membranes. When localized to the conjunctiva, it is known as ocular cicatricial pemphigoid, a potentially blinding disease. Ocular cicatricial pemphigoid is an indication for systemic immunosuppressive treatment to achieve adequate remission. Immunosuppressive agents are selected with a "stepladder" approach, commencing with medications having the fewest side effects. We provide an update of the literature on immunomodulatory agents since 2011 as additional treatment modalities have been explored in the last 4 years...
May 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/26632795/igm-ocular-cicatricial-pemphigoid-a-unique-insight-into-the-immune-system
#14
Noor Tazudeen, Sonoa Au, Jonathan Pewitt, Elmer Tu, Iris K Aronson
A 42-year-old man with ocular erythema and scarring had a conjunctival biopsy revealing depostion of IgM and C3 without IgG at the epithelial basement membrane zone.  Treatment with doxycyline, dapsone, and mycophenolate mofetil was unsuccessful and treatment with rituximab has led to partial remission of the conjunctival inflammation. He has undergone 4 cycles of rituximab treatment at intervals of 12 to 18 months.
October 2015: Dermatology Online Journal
https://www.readbyqxmd.com/read/26569118/ngf-modulates-trkangfr-p75ntr-in-%C3%AE-sma-expressing-conjunctival-fibroblasts-from-human-ocular-cicatricial-pemphigoid-ocp
#15
Alessandra Micera, Barbara Stampachiacchiere, Antonio Di Zazzo, Roberto Sgrulletta, Magdalena Cortes, Eduardo Maria Normando, Alessandro Lambiase, Stefano Bonini
OBJECTIVE: In a previous study, we reported the upregulation of Nerve Growth Factor (NGF) and trkANGFR expression in Ocular Cicatricial Pemphigoid (OCP), an inflammatory and remodeling eye disease. Herein, we hypothesize a potential NGF-driven mechanism on fibroblasts (FBs) during OCP remodeling events. To verify, human derived OCP-FBs were isolated and characterized either at baseline or after NGF exposure. MATERIALS AND METHODS: Conjunctival biopsies were obtained from 7 patients having OCP and 6 control subjects (cataract surgery)...
2015: PloS One
https://www.readbyqxmd.com/read/26276169/protective-effect-of-soft-contact-lenses-after-boston-keratoprosthesis
#16
Leah L Kammerdiener, Jaime Lynn Speiser, James V Aquavella, Mona Harissi-Dagher, Claes H Dohlman, James Chodosh, Joseph B Ciolino
PURPOSE: To evaluate associations between preoperative diagnosis, soft contact lens (SCL) retention and complications. METHODS: A retrospective chart review was conducted of 92 adult patients (103 eyes) who received a Boston keratoprosthesis type I at the Massachusetts's Eye and Ear Infirmary or the Flaum Eye Institute. Records were reviewed for preoperative diagnosis, SCL retention and subsequent complications. Preoperative categories included 16 autoimmune (Stevens-Johnson syndrome, ocular cicatricial pemphigoid, rheumatoid arthritis and uveitis), 9 chemical injury and 67 'other' (aniridia, postoperative infection, dystrophies, keratopathies) patients...
April 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/26176872/isolation-and-investigation-of-presumptive-murine-lacrimal-gland-stem-cells
#17
Philipp Ackermann, Susann Hetz, Julia Dieckow, Martin Schicht, Anja Richter, Charli Kruse, Insa S Schroeder, Matthias Jung, Friedrich P Paulsen
PURPOSE: Aqueous tear deficiency due to lacrimal gland insufficiency is one of the major causes of dry eye disease. In severe cases, such as Sjogren's syndrome, Stevens-Johnson syndrome, or ocular cicatricial pemphigoid, therapy with artificial tears is often insufficient to relieve severe discomfort, prevent progressive ocular surface disease, or enable visual rehabilitation by corneal transplantation. Cell or organ generation from stem cells, resulting in tear-like secretion, presents an option as a suitable alternative treatment...
July 2015: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/26093286/sealing-of-the-gap-between-the-conjunctiva-and-tenon-capsule-to-improve-symblepharon-surgery
#18
Dandan Zhao, Han Y Yin, Anny Cheng, Rendian Chen, Hosam Sheha, Scheffer C G Tseng
PURPOSE: To report the surgical outcome of "sealing the gap" in treating symblepharon caused by various etiologies other than recurrent pterygium. DESIGN: Retrospective, interventional case series. METHODS: Sixteen eyes of 14 patients with pathogenic symblepharon were consecutively operated by conjunctival recession, sealing the gap between recessed conjunctiva and Tenon capsule with a running 9-0 nylon suture, and covering of the bare sclera with amniotic membrane...
September 2015: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/25863854/characteristics-of-patients-with-ocular-cicatricial-pemphigoid-referred-to-major-tertiary-hospital
#19
Yakov Goldich, Setareh Ziai, Pichaporn Artornsombudh, Noa Avni-Zauberman, Uri Elbaz, David S Rootman, Clara C Chan
OBJECTIVE: To evaluate the demographic and clinical characteristics of patients referred to a tertiary care hospital cornea clinic for ocular cicatricial pemphigoid (OCP) assessment. DESIGN: Retrospective, nonrandomized, consecutive case series. PARTICIPANTS: Thirty three patients with OCP who were treated at the corneal clinic of Toronto Western Hospital from 2003 to 2012. METHODS: Database search of patients from 2003 to 2012 with a referral request or diagnosis of OCP was conducted at a tertiary care hospital cornea clinic...
April 2015: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/25785527/long-term-rebamipide-and-diquafosol-in-two-cases-of-immune-mediated-dry-eye
#20
Mio Yamane, Yoko Ogawa, Masaki Fukui, Mizuka Kamoi, Yumiko Saijo-Ban, Saori Yaguchi, Shin Mukai, Tetsuya Kawakita, Shigeto Simmura, Kazuo Tsubota
PURPOSE: Two new drugs with mucin-inducing and secretion-promotive effects, rebamipide and diquafosol, were recently approved as topical dry-eye treatments. We report two cases in which the long-term use of mucin-inducing eye drops improved chronic ocular graft-versus-host disease (cGVHD)-related dry eye and ocular cicatricial pemphigoid (OCP)-like disease. CASE REPORTS: Case 1. A 61-year-old woman had cGVHD-related dry eye that resisted traditional medications...
April 2015: Optometry and Vision Science: Official Publication of the American Academy of Optometry
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